The global pandemic has radically realigned the purpose of innovation, drawing global focus towards economic, human and ecological health, a global infodemic, and the pressing need to invest in technologies of impact. Jumpstart’s Fall Issue takes a close look at the tectonic shifts within the innovation ecosystem that have taken place due to the global pandemic. We look closely at how startup investment and legacy industries have responded to the new order, and how the startup survival narrative has unfolded over the many months of the pandemic. Our cover story is an intimate account of professional boxing legend and one of the highest paid athletes in the world Emmanuel ‘Manny’ Pacquiao, and his ascent as a boxer, politician, businessman and philanthropist. We also converse with startups from critical impact sectors spanning health, sustainability and sanitation in this issue, dive into Thailand’s startup culture, and answer questions about the future of the Gig Economy.