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620: He ‘ike ‘ana ia i ka pono
from May–June 2022
EmpowEr Your GoldEn YEars
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Aging Gracefully with Hyperbaric Oxygen Therapy
The use of Hyperbarics has long been associated with treatment of decompression injuries associated with SCUBA and in the treatment of non-healing wounds. In 2020 Dr. Efrati, and again in 2022 with Dr. Hadanny, these two landmark studies demonstrated the positive effects of hyperbaric oxygen therapy on genetic expression associated with aging and longevity…in humans. Hadanny’s study was able to demonstrate 1,342 genes upregulated, and 570 genes downregulated. The upregulated genes included anti-inflammatory, growth and repair hormones genes, while downregulated genes included pro-inflammation and apoptosis genes associated with cell death. This is the first time in humans that hyperbarics is shown to have direct effects on transcriptome in genetics and demonstrates significant changes in gene expression of the normal aging population. (Hadanny) Healing in the body depends on sufficient oxygen levels in the cells. Often times injuries and sickness linger as oxygen levels are not sufficient to support normal cell function. Hyperbaric oxygen therapy is an avenue that provides increased oxygen levels to damaged and sick areas of the body gently and effectively. Hyperbarics has been able to exhibit many benefits to individuals seeking optimal body and brain function. While many people utilize hyperbaric oxygen therapy for sickness and injuries, there are also many who utilize hyperbarics for improving and “supercharging” their general health. In the first scientific study published in November 2020 it was demonstrated that they could turn back the clock in areas believed to be responsible for the frailty and ill health that comes with aging. During the aging process, telomeres, the protective covers at the end of each chromosome, shorten progressively. The accumulation of shortening of these telomeres is believed to contribute to cells becoming more inactive; what is called senescence. Generally, the more senescence present, the unhealthier the tissues and organs systems. A research group at Shamir Medical Center of Tel Aviv University placed groups of people into categories and subjected them to hyperbaric oxygen therapy over a period of three months. Throughout the study, various cells were sampled and observed. The telomere region of each chromosome was observed to be increased on an average of 37%. Decreasing senescence or “zombie” cells was observed at levels never before seen. It is understood that lifestyle modifications such as intense exercise and nutrition have been shown to have inhibiting effect on telomere shortening up to 11-16%. However, people in the study subjected to hyperbaric oxygen therapy were able to decrease genetic damage and aging characteristics by 25 years. How is this possible? By elongation of telomeres and upregulation of gene expression far beyond any current available interventions or lifestyle modifications. Again, findings in these clinical trials are remarkable, as the genetic expression of aging individuals in the study were able to decrease their genetic age by as much as 25 years. Furthermore, the reduction of senescent cells also implies improvements with tissue function.
Q: How does hyperbarics work in the body?
A: In conditions at sea level, only red blood cells have the ability to carry oxygen in the bloodstream to the cells. By way of hyperbaric oxygen therapy, breathing in oxygen molecules dissolve into the liquid part of the blood called plasma. This enables oxygen to be delivered to compromised and injured areas of the body that may not have sufficient blood flow. This dissolving oxygen into the plasma is made possible by a physics gas law known as “Henry’s law “and is unable to occur with breathing oxygen at sea level without additional atmospheric increase of pressure.
Q: Is there a difference in hyperbaric chambers and operations?
A: Yes, hyperbarics are performed here at our office by board certified individuals, and our chambers are FDA and ASME certified. A certified safety director is always present.
Q: What are some of the effects of Hyperbarics in the body?
A: Observations during hyperbaric oxygen therapy studies include decrease swelling and inflammation, growth of new blood vessels and nerve tissue, neuroplasticity, significantly increased stem cell proliferation, and improved brain function. A general feeling of improved well-being is often reported.
IF YOU WOULD LIKE TO EXPERIENCE the positive effects of hyperbarics, contact Dr. Mizuba to see how this may benefit you. Dr. Mizuba is a diplomate of the American Chiropractic Board of Sports Physicians, a member of Undersea and Hyperbaric Medical Society, board-certified in hyperbaric oxygen therapy level lll and hyperbarics safety director certified. He teaches hyperbaric safety operations and compliance internationally. Dr. Mizuba continues to serve as a staff doctor for the USGA each summer and in the healthcare system of Major League Baseball.
Dr. Eric Mizuba
This sponsored content is courtesy of The O2 Lab/Dr. E.S. Mizuba, D.C., DACBSP, CHT, CSD, located at 65-1206 Mamalahoa Hwy. in Waimea. For more information visit www.drmizuba.com or call 808.491.2462.
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