Marmara Medical Journal by fethi yÃ¼ksel

Online ISSN : 1309-9469 Print ISSN : 1019-1941

Volume / Cilt 26 Issue / Sayı 2 May / Mayıs 2013

Marmara Medical Journal Marmara Üniversitesi Tıp Fakültesi Dergisi

www.marmaramedicaljournal.org

Marmara Medical Journal DERGI HAKKINDA Marmara Medical Journal, Marmara Üniversitesi Tıp Fakültesi tarafından yayınlanan multidisipliner Ulusal ve uluslararası tüm tıbbi kurum ve personele ulaşmayı hedeﬂeyen bilimsel bir dergidir. Marmara Üniversitesi Tıp Fakültesi Dergisi, tıbbın her alanını içeren klinik ve deneysel çalışmaları, ilginç olgu bildirimlerini, derlemeleri, davet edilmiş derlemeleri, Editöre mektupları, toplantı, haber ve duyuruları, klinik haberleri ve ilginç araştırmaların özetlerini, ayırıcı tanı, tanınız nedir başlıklı olgu sunumlarını, soru-cevaplar, tıp gündemini belirleyen güncel konuları ve özellikle Halk Sağlığı ve Tıp Eğitimi ile ilgili çalışmaları ve tıp öğrencilerinin yaptıkları çalışmaları yayınlar. Periyodu: Yılda 3 sayı olarak Ocak, Mayıs ve Ekim aylarında yayınlanmaktadır. Yayına başlama tarihi : 1988 e-Yayına başlama tarihi: 2004 (2004 yılından 2011 yılına kadar sadece elektronik ortamda yayınlanmıştır.) Yayın Dili : Türkçe, İngilizce ISSN : 1019-1941 eISSN : 1309-9469 Temel Hedef Kitlesi: Tıp alanında tüm branşlardaki hekimler, uzman ve öğretim üyeleri, tıp öğrencileri İndekslendiği dizinler: EBSCO, SCOPUS, EMBASEExcerpta Medica, DOAJ (Directory of Open Access Journals), Cross Ref, ULRICH’s Database, Google Scholar, British Library, ULAKBİM Tıp Veri Tabanı (Türk Tıp Dizini), Türkiye Atif Dizini, Türk Medline (Ulusal Atif İndeksi), Türkiye Klinikleri Tıp Veri Tabanı, Milli Kütüphane-Türkiye Makaleler Bibliyografyası Makalelerin ortalama değerlendirme süresi: 2 haftadır Yayın Hakları: Marmara Medical Journal’in basılı ve web ortamında yayınlanan yazı, resim, şekil, tablo ve uygulamalar yazılı izin alınmadan kısmen veya tamamen herhangi bir vasıtayla basılamaz. Bilimsel amaçlarla kaynak göstermek kaydıyla özetleme ve alıntı yapılabilir. Makale takibi - İletişim Seza Arbay Marmara Medical Journal (Marmara Üniversitesi Tıp Fakültesi Dergisi) Marmara Üniversitesi Tıp Fakültesi Dekanlığı, Tıbbiye cad No:49 Haydarpaşa 34668, İstanbul Tel: +90 216 4144734 Faks: +90 216 4144731 E-posta: mmj@marmara.edu.tr Yayınevi Marmara Üniversitesi Yayınevi Göztepe Kampüsü, Kadıköy 34722 İstanbul Tel. +90 216 348 4379, Faks +90 216 348 4379 E-posta: yayinevi@marmara.edu.tr Yayın Hizmetleri BAYT Bilimsel Araştırmalar Basın Yayın ve Tanıtım Ltd. Şti. Ziya Gökalp Cad. 30/31, Kızılay 16420 Ankara Tel. 0312 431 3062 Faks: 0312 431 3602 E-posta: info@bayt.com.tr www.bayt.com.tr Baskı Tarihi: Mayıs 2013

Dergi asitsiz kağıda basılmaktadır.

ABOUT The Marmara Medical Journal is a multidisciplinary, academic publication of Marmara University, School of Medicine. It is an open access, double blind peer-reviewed journal. The journal aims to publish papers of general interest relating to advances in medical practice and novel treatments that will be of interest to general practitioners, medical students, and senior practitioners and specialists. We especially welcome papers on Public Health and Medical Education. MMJ also aims to publish all types of research conducted by medical students. It includes original research papers, case reports, reviews, articles about clinical and practical applications and editorials, short reports, letters to the editor and occcasionally a photo-quiz. Frequency : Three times a year ( January, May, October) Year of first print issue : 1988 Year of first online issue : 2004 (Between 2004 and 2011 the Journal was published solely in an electronic format.) Print ISSN : 1019-1941 eISSN : 1309-9469 Language : English and Turkish The articles published in the Marmara Medical Journal are indexed or abstracted in: EBSCO, SCOPUS, EMBASE / Excerpta Medica, DOAJ (Directory of Open Access Journals), Cross Ref, ULRICH’S Database, Google Scholar, The British Library, Turkish Academic Network and Information Center (ULAKBİM)-Turkish Medical Database, TURK MEDLINE - Türk Sağlık Bilimleri İndeksi (Index of Turkish Health Sciences), Türkiye Makaleler Bibliyografyası (Bibliography of Articles in Turkish Periodicals), Türkiye Klinikleri Tıp Dizini (Turkish Citation Index) We aim to reach a decision on all manuscripts within two weeks of submission. Permission Request: Manuscripts, tables, graphics, figures and pictures published in the Marmara Medical Journal cannot be reproduced, archieved in a system, used in advertisement materials, without a written permision. Citations can be included only in scientific articles with referral.

Correspondence and communications Seza Arbay Marmara Medical Journal (Marmara Üniversitesi Tıp Fakültesi Dergisi) Marmara Üniversitesi Tıp Fakültesi Dekanlığı, Tıbbiye cad No:49 Haydarpaşa 34668, İstanbul, Turkey Tel: +90 216 4144734 Faks: +90 216 4144731 E-mail: mmj@marmara.edu.tr Publishing House Marmara Üniversity Press Göztepe Kampüsü, Kadıköy 34722 İstanbul, Turkey Tel. +90 216 348 4379, Faks +90 216 348 4379 E-mail: yayinevi@marmara.edu.tr Publishing Services BAYT Scientiﬁc Research Publishing and Presentation Co. Ltd. Ziya Gökalp Cad. 30/31, Kızılay 16420 Ankara, Turkey Tel. +90 312 431 3062 Fax: +90 312 431 3602 E-mail: info@bayt.com.tr Printing Date: May 2013

The Journal is printed on acid-free paper.

Marmara Üniversitesi Tıp Fakültesi Dergisi

Sahibi Marmara Üniversitesi Tıp Fakültesi adına / Owner, In the name of Deanship of Marmara University, School of Medicine Dekan / Dean Prof. Dr. Hasan Fevzi Batırel Editör / Editor-in-Chief Prof. Dr. Dilek Gogas Yavuz Editör Yardımcıları /Associate Editors Prof. Dr. Işıl Barlan Prof. Dr. Atila Karaalp Doç. Dr. Asım Cingi Doç. Dr. Beste Atasoy Doç. Dr. Evrim Karadağ Saygı Doç. Dr. Arzu Akşit İlki İstatistik Editörü / Statistics Editor Prof. Dr. Nural Bekiroğlu Koordinatörler / Coordinators Seza Arbay, MS Dr. Vera Bulgurlu Uluslararası Editörler Kurulu / International Editorial Board Adnan Dağçınar, İstanbul, Türkiye / Istanbul, Turkey Athanasios Fassas, Arkansas, ABD / Arkansas, USA Ayşegül Atmaca, Samsun, Türkiye / Samsun, Turkey Cem Ergon, İzmir, Türkiye / Izmir, Turkey Christoph Grüber, Frankfurt, Almanya / Frankfurt, Germany Christos Mantzoros, Boston, ABD / Boston, USA Devrim Dündar, Kocaeli, Türkiye / Kocaeli, Turkey Dilek Seçkin, İstanbul, Türkiye / Istanbul, Turkey Emin Kansu, Ankara, Türkiye / Ankara, Turkey Esen Akpek, Baltimore, ABD / Baltimore, USA Evren Yaşar, Ankara, Türkiye / Ankara, Turkey Feray Cinevre Soyupak, İsparta, Türkiye / Isparta, Turkey George Velmahos, Boston, ABD / Boston, USA Hakkı Arıkan, İstanbul, Türkiye / Istanbul, Turkey İbrahim Şahin, Malatya, Türkiye / Malatya, Turkey İhsan Nuri Akpınar, İstanbul, Türkiye / Istanbul, Turkey Isac I Schnirer, Tel Aviv, İsrail / Tel Aviv, Israel Jan Lotvall, Gothenburg, İsveç / Gothenburg, Sweden Kaan Boztuğ, Viyana, Avusturya / Vienna, Austria Kayıhan Uluç, İstanbul, Türkiye / Istanbul, Turkey Kazunori Okabe, Ube, Japonya / Ube, Japan Lydia Ioannido Mouzaka, Atina, Yunanistan / Athens, Greece Muzaffer Metintaş, Eskişehir, Türkiye / Eskisehir, Turkey Neşe Perdahlı Fiş, İstanbul, Türkiye / Istanbul, Turkey Neşe Tuncer Elmacı, İstanbul, Türkiye / Istanbul, Turkey Nima Rezaei, Tahran, İran / Tehran, Iran Oğuzhan Deyneli, İstanbul, Türkiye / Istanbul, Turkey Olcay Yeğin, Antalya, Türkiye / Antalya, Turkey Önder Ergönül, İstanbul, Türkiye / Istanbul, Turkey Özge Ecmel Onur, İstanbul, Türkiye / Istanbul, Turkey Özlem Yenice, İstanbul, Türkiye / Istanbul, Turkey Rainer W Guillery, Oxford, İngiltere / Oxford, England R Lucian Chirieac, Boston, ABD / Boston, USA Robert W Mahley, San Francisco, ABD / San Francisco, USA Scott J Swanson, Boston, ABD / Boston, USA Seval Güneşer, Adana, Türkiye / Adana, Turkey Todor A Popov, Sofya, Bulgaristan / Soﬁa, Bulgaria Toni Lerut, Leuven, Belçika / Leuven, Belgium Yoshifumi Naka, New York, ABD / New York, USA Yusuf Yazıcı, New York, ABD / New York, USA Tevﬁk Yoldemir, İstanbul, Türkiye / Istanbul, Turkey Ziya Salihoğlu, İstanbul, Türkiye / Istanbul, Turkey

Marmara Medical Journal

Marmara Üniversitesi Tıp Fakültesi Dergisi

Yazarlara Bilgi Marmara Medical Journal - Marmara Üniversitesi Tıp Fakültesi Dergisine ilginize teşekkür ederiz. Derginin elektronik ortamdaki yayınına erişim www.marmaramedicaljournal.org adresinden serbesttir. Marmara Medical Journal tıbbın klinik ve deneysel alanlarında özgün araştırmalar, olgu sunumları, derlemeler, davet edilmiş derlemeler, mektuplar, ilginç, fotoğraﬂı soru-cevap yazıları (photo-quiz), editöre mektup, toplantı, haber ve duyuruları, klinik haberleri ve ilginç araştırmaların özetlerini yayınlamaktadır. Yılda 3 sayı olarak Ocak, Mayıs ve Ekim aylarında yayınlanan Marmara Medical Journal hakemli ve multidisipliner bir dergidir. Gönderilen yazılar Türkçe veya İngilizce olabilir. Değerlendirme süreci Dergiye gönderilen yazılar, ilk olarak dergi standartları açısından incelenir. Derginin istediği forma uymayan yazılar, daha ileri bir incelemeye gerek görülmeksizin yazarlarına iade edilir. Zaman ve emek kaybına yol açılmaması için, yazarlar dergi kurallarını dikkatli incelemeleri önerilir. Dergi kurallarına uygunluğuna karar verilen yazılar Editörler Kurulu tarafından incelenir ve en az biri başka kurumdan olmak üzere iki ya da daha fazla hakeme gönderilir. Editör, Kurulu yazıyı reddetme ya da yazara(lara) ek değişiklikler için gönderme veya yazarları bilgilendirerek kısaltma yapmak hakkına sahiptir. Yazarlardan istenen değişiklik ve düzeltmeler yapılana kadar, yazılar yayın programına alınmamaktadır. Marmara Medical Journal gönderilen yazıları sadece online olarak http://marmaramedicaljournal.org/submit adresinden kabul etmektedir. Yazıların bilimsel sorumluluğu yazarlara aittir. Marmara Medical Journal yazıların bilimsel sorumluluğunu kabul etmez. Makale değerlendirmek için gönderildiği sırada Yayın Hakkı Devir Formu ve çıkar çatışması formu imzalanıp dergiye iletilmelidir. Gönderilen yazıların dergide yayınlanabilmesi için daha önce başka bir bilimsel yayın organında yayınlanmamış olması gerekir. Daha önce sözlü ya da poster olarak sunulmuş çalışmalar, yazının başlık sayfasında tarihi ve yeri ile birlikte belirtilmelidir. Yayınlanması için başvuruda bulunulan makalelerin, adı geçen tüm yazarlar tarafından onaylanmış olması ve çalışmanın başka bir yerde yayınlanmamış olması ya da yayınlanmak üzere değerlendirmede olmaması gerekmektedir. Çalışma ile ilgili herhangi bir mali ya da diğer çıkar çatışması var ise çıkar çatışması formunda belirtilmelidir. (1, 2) Yazıların hazırlanması Derginin yayın dili İngilizce veya Türkçe’dir. Türkçe yazılarda Türk Dil Kurumu Türkçe Sözlüğü (http://tdk.org.tr) esas alınmalıdır. Anatomik terimlerin ve diğer tıp terimlerinin adları Latince olmalıdır. Gönderilen yazılar, yazım kuralları açısından Uluslararası Tıp Editörleri Komitesi tarafından hazırlanan “Biomedikal Dergilere Gönderilen Makalelerde Bulunması Gereken Standartlar“a (Uniform Requirements For Manuscripts Submittted to Biomedical Journals) uygun olarak hazırlanmalıdır. (http://www. ulakbim.gov.tr /cabim/vt) Makale içinde kullanılan kısaltmalar Uluslararası kabul edilen şeklide olmalıdır (http://www.journals.tubitak.gov.tr/kitap/ maknasyaz/) kaynağına başvurulabilir. Birimler, Ağırlıklar ve Ölçüler 11. Genel Konferansı’nda kabul edildiği şekilde Uluslararası Sistem (SI) ile uyumlu olmalıdır. Makaleler Word, WordPerfect, EPS, LaTeX, text, Postscript veya RTF formatında, şekil ve fotoğraﬂar ise ayrı dosyalar halinde TIFF, JPG, BMP, Postscript veya EPS formatında kabul edilmektedir. Yazı kategorileri Yazının gönderildiği metin dosyasının içinde sırasıyla, Türkçe başlık, özet, anahtar sözcükler, İngilizce başlık, özet, İngilizce anahtar sözcükler, makalenin metini, kaynaklar, her sayfaya bir tablo olmak üzere tablolar ve son sayfada şekillerin (varsa) alt yazıları şeklinde olmalıdır. Metin dosyanızın içinde, yazar isimleri ve kurumlara ait bilgi, makalede kullanılan şekil ve resimler olmamalıdır.

Özgün araştırma makaleleri Türkçe ve İngilizce özetler yazı başlığı ile birlikte verilmelidir. (i) Özetler: Amaç (Objectives), Gereç ve Yöntem (Materials and Methods) ya da Hastalar ve Yöntemler (Patients and Methods), Bulgular (Results) ve Sonuç (Conclusion) bölümlerine ayrılmalı ve 200 sözcüğü geçmemelidir. (ii) Anahtar Sözcükler İngilizce anahtar kelimeler Medical Subject Headings (MeSH)’e, Türkçe anahtar kelimeler ise Türkiye Bilim Terimleri (TBT)’ne uygun olarak seçilmelidir. Yazının diğer bölümleri, (iii) Giriş, (iv) Gereç ve Yöntem / Hastalar ve Yöntemler, (v) Bulgular, (vi) Tartışma ve (vii) Kaynaklar’dır. Başlık sayfası dışında yazının hiçbir bölümünün ayrı sayfalarda başlatılması zorunluluğu yoktur. Maddi kaynak, çalışmayı destekleyen burslar, kuruluşlar, fonlar, metnin sonunda teşekkürler kısmında belirtilmelidir. Olgu sunumları İngilizce ve Türkçe özetleri kısa ve tek paragraflık olmalıdır. Olgu sunumu özetleri ağırlıklı olarak mutlaka olgu hakkında bilgileri içermektedir. Anahtar sözcüklerinden sonra giriş, olgu(lar) tartışma ve kaynaklar şeklinde düzenlenmelidir. Derleme yazıları İngilizce ve Türkçe başlık, İngilizce ve Türkçe özet ve İngilizce ve Türkçe anahtar kelimeler yer almalıdır. Kaynak sayısı 50 ile sınırlanması önerilmektedir. Kaynaklar Kaynaklar yazıda kullanılış sırasına göre numaralanmalıdır. Kaynaklarda verilen makale yazarlarının sayısı 6 dan fazla ise ilk 3 yazar belirtilmeli ve İngilizce kaynaklarda ilk 3 yazar isminden sonra “et al.”, Türkçe kaynaklarda ise ilk 3 yazar isminden sonra “ ve ark. “ ibaresi kullanılmalıdır. Noktalamalara birden çok yazarlı bir çalışmayı tek yazar adıyla kısaltmamaya ve kaynak sayfalarının başlangıç ve bitimlerinin belirtilmesine dikkat edilmelidir. Kaynaklarda verilen dergi isimleri Index Medicus’a (http://www.ncbi.nim.nih.gov/sites/ entrez/query.fcgi?db=nlmcatalog) veya Ulakbim/Türk Tıp Dizini’ne uygun olarak kısaltılmalıdır. Makale: 1. Yazici D, Taş S, Emir H, Sunar H. Comparison of premeal mixed insulin three times daily and basalbolus insulin therapy started post-operatively on patients having coronary artery bypass graft surgery. Marmara Med J 2011; 25:16-9. doi: 10.5472/MMJ.2011.02134.1 2. Walker M, Hull A. Preterm labor and birth. In: Taeusch HW, Ballard RA, eds. Avery’s Diseases of the Newborn. Philadelphia: WB Saunders, 1998: 144,153. Kitap: Norman IJ, Redfern SJ, (editors). Mental health care for elderly people. New York: Churchill Livingstone, 1996. Kitaptan Bölüm: Phillips SJ, Whisnant JP Hypertension and stroke. In: Laragh JH, Brenner BM, editors. Hypertension: Pathophysiology, Diagnosis, and Management. 2nd ed. New York: Raven Pres, 1995:465-78. Kaynak web sitesi ise: Kaynak makalerdeki gibi istenilen bilgiler verildikten sonra erişim olarak web sitesi adresi ve erişim tarihi bildirilmelidir. Kaynak internet ortamında basılan bir dergi ise: Kaynak makaledeki gibi istenilen bilgiler verildikten sonra erişim olarak URL adresi ve erişim tarihi verilmelidir. Kongre Bildirileri: Bengtsson S, Solheim BG. Enforcement of data protection, privacy and security in medical informatics. In: Lun KC, Degoulet P, Piemme TE, Rienhoff O, editors. MEDINFO 92. Proceedings of the 7th World Congress on Medical Informatics; 1992 Sep 6-10; Geneva, Switzerland. Amsterdam: North-Holland; 1992:1561-5. Tablo, şekil, grafik ve fotoğraf Tablo, şekil grafik ve fotoğraflar yazının içine yerleştirilmiş halde gönderilmemeli. Tablolar, her sayfaya bir tablo olmak üzere yazının gönderildiği dosya içinde olmalı ancak yazıya ait şekil,

grafik ve fotografların her biri ayrı bir imaj dosyası ( jpeg) olarak gönderilmelidir. Tablo başlıkları ve şekil altyazıları eksik bırakılmamalıdır. Şekillere ait açıklamalar yazının gönderildiği dosyanın en sonuna yazılmalıdır. Tablo, şekil ve grafiklerin numaralanarak yazı içinde yerleri belirtilmelidir. Tablolar yazı içindeki bilginin tekrarı olmamalıdır. Makale yazarlarının, makalede eğer daha önce yayınlanmış alıntı yazı, tablo, şekil, grafik, resim vb var ise yayın hakkı sahibi ve yazarlardan yazılı izin almaları ve makale üst yazısına ekleyerek dergiye ulaştırmaları gerekmektedir. Tablolar metin içinde atıfta bulunulan sıraya göre romen rakkamı ile numaralanmalıdır. Her tablo ayrı bir sayfaya ve tablonun üst kısmına kısa ancak anlaşılır bir başlık verilerek hazırlanmalıdır. Başlık ve dipnot açıklayıcı olmalıdır. Sütun başlıkları kısa ve ölçüm değerleri parantez içinde verilmelidir. Bütün kısaltmalar ve semboller dipnotta açıklanmalıdır. Dipnotlarda şu semboller: († ‡ ¶ §) ve P değerleri için ise *, **, *** kullanılmalıdır. SD veya SEM gibi istatistiksel değerler tablo veya şekilin altında not olarak belirtilmelidir. Grafik, fotoğraf ve çizimler ŞEKİL olarak adlandırılmalı, makalede geçtiği sıraya göre numaralanmalı ve açıklamaları şekil altına yazılmalıdır Şekil alt yazıları, ayrıca metinin son sayfasına da eklenmelidir. Büyütmeler, şekilde uzunluk birimi (bar çubuğu içinde) ile belirtilmelidir. Mikroskopik resimlerde büyütme oranı ve boyama tekniği açıklanmalıdır. Etik Marmara Medical Journal’a yayınlanması amacı ile gönderilen yazılar Helsinki Bildirgesi, İyi Klinik Uygulamalar Kılavuzu, İyi Laboratuar Uygulamaları Kılavuzu esaslarına uymalıdır. Gerek insanlar gerekse hayvanlar açısından etik koşullara uygun olmayan yazılar yayınlanmak üzere kabul edilemez. Marmara Medical Journal, insanlar üzerinde yapılan araştırmaların önceden Araştırma Etik Kurulu tarafından onayının alınması şartını arar. Yazarlardan, yazının detaylarını ve tarihini bildirecek şekilde imzalı bir beyan ile başvurmaları istenir. Çalışmalar deney hayvanı kullanımını içeriyorsa, hayvan bakımı ve kullanımında yapılan işlemler yazı içinde kısaca tanımlanmalıdır. Deney hayvanlarında özel derişimlerde ilaç kullanıldıysa, yazar bu derişimin kullanılma mantığını belirtmelidir. İnsanlar üzerinde yapılan deneysel çalışmaların sonuçlarını bildiren yazılarda, Kurumsal Etik Kurul onayı alındığını ve bu çalışmanın yapıldığı gönüllü ya da hastalara uygulanacak prosedürlerin özelliği tümüyle kendilerine anlatıldıktan sonra, onaylarının alındığını gösterir cümleler yer almalıdır. Yazarlar, bu tür bir çalışma söz konusu olduğunda, uluslararası alanda kabul edilen kılavuzlara ve TC. Sağlık Bakanlığı tarafından getirilen ve 28 Aralık 2008 tarih ve 27089 sayılı Resmi Gazete’de yayınlanan “Klinik araştırmaları Hakkında Yönetmelik” ve daha sonra yayınlanan 11 Mart 2010 tarihli resmi gazete ve 25518 sayılı “Klinik Araştırmalar Hakkında Yönetmelikte Değişiklik Yapıldığına Dair Yönetmelik” hükümlerine uyulduğunu belirtmeli ve kurumdan aldıkları Etik Komitesi onayını göndermelidir. Hayvanlar üzerinde yapılan çalışmalar için de gereken izin alınmalı; yazıda deneklere ağrı, acı ve rahatsızlık verilmemesi için neler yapıldığı açık bir şekilde belirtilmelidir. Hasta kimliğini tanıtacak fotoğraf kullanıldığında, hastanın yazılı onayı gönderilmelidir.

Yazı takip ve sorularınız için iletişim: Seza Arbay Marmara Universitesi Tıp Fakültesi Dekanlığı, Tıbbiye Caddesi, No: 49, Haydarpaşa 34668, İstanbul Tel: +90 216 4144734 Faks: +90 216 4144731 e-posta: mmj@marmara.edu.tr

Marmara Medical Journal

Marmara Üniversitesi Tıp Fakültesi Dergisi

Instructions to Authors The Marmara Medical Journal publishes original scientific research, case reports, reviews and letters. Manuscripts submitted under multiple authorship are reviewed on the assumption that all listed authors concur with the submission and that a copy of the final manuscript has been approved by all authors and tacitly or explicitly by the responsible authorities in the laboratories where the work was carried out. (3) Manuscripts are accepted for review with the understanding that no substantial portion of the study has been published or is under consideration for publication elsewhere. Regular articles should be approximately 20-25 pages doublespaced , including references, with margins of 2.5 cm. Review articles should be similar in length to a regular article with approximately 50 references. Manuscript files must be prepared in Word, WordPerfect, EPS, LaTeX, text, Postscript, or RTF format. Figures/Images should be embedded in the Manuscript file or sent as external files in TIFF, JPG, BMP, Postscript, or EPS format. The Marmara Medical Journal is in compliance with the Uniform Requirements for Manuscripts Submitted to Biomedical Journals created by International Committee for Medical Editors.

2) a statement that all participants gave informed consent. d. Results. Duplication between the text of this section and material presented in tables and figures should be avoided. Tabular presentation of masses of negative data must be avoided and replaced with a statement in the text whenever possible. The results must be presented clearly, concisely and without comment. e. Discussion. This section must relate the significance of the work to existing knowledge in the field and indicate the importance of the contribution of this study. Unsupported hypotheses and speculation should be omitted. f. References. The style of references is that of the Index Medicus. List all authors when there are six or fewer, when there are seven or more list the first three, then add “et al.”. Unpublished results or personal communications should be cited as such in the text. Please note the following examples: 1. Yazici D, Taş S, Emir H, Sunar H. Comparison of premeal mixed insulin three times daily and basal-bolus insulin therapy started post-operatively on patients having coronary artery bypass graft surgery. Marmara Med J 2011; 25:16-9. doi: 10.5472/MMJ.2011.02134.1

Preparation of Manuscript

2. Walker M, Hull A. Preterm labor and birth. In: Taeusch HW, Ballard RA, eds. Avery’s Diseases of the Newborn. Philadelphia: WB Saunders, 1998: 144,153.

a. The Title page should contain the article title, authors’ names and academic or professional afﬁliations, and the address for manuscript correspondence (including e-mail address and telephone and fax numbers). Pages should be numbered consecutively and organized as follows:

3. Lawton J, Ahmad N, Hallowell N, Hanna L, Douglas M. Perceptions and experiences of taking oral hypoglycaemic agents among people of Pakistani and Indian origin: qualitative study. BMJ 2005;30:1247-51. doi:10.1136/ bmj.38460.642789.EO

(1) two structured abstracts (Turkish and English) of not more than 200 words each must be included. The abstracts should be divided into the following sections: Objective, Methods, Results and Conclusion, (2) Keywords (3-6 keywords, in Turkish and English should be taken from Medical Subject Headings (MeSH) from Index Medicus), (3) Introduction, (4) Materials and Methods, (5) Results, (6) Discussion and (7) References.

4. WONCA Ad Hoc Task Force on Tobacco Cessation. http://globalfamilydoctor.com/publications/new/ november/09.htm.

b. Introduction. State why the investigation was carried out, note any relevant published work, and delineate the objective of the investigation. c. Methods. New methods or signiﬁcant improvements of methods or changes in old methods must be described. Details regarding animal housing conditions should be given. All clinical studies must contain : 1) a statement that all experimental protocols have been approved by the Ethical Committee of the Institution prior to the commencement of the studies,

g. Figures. Diagrams and illustrations should be given Arabic numerals. All ﬁgure legends should be grouped and written on a separate page. Each Figure should be in one of the following preferred formats: Tiff, JPEG, PDF, and EPS. h. Tables. Tables should be numbered consecutively with Roman numerals in order of appearance in the text. Type each table double-spaced on a separate page with a short descriptive title directly above and with essential footnotes below. Units will be in general accordance with the International System (SI) as adopted by the 11th General Conference on Weights and Measures. Compliance with the principles of Declaration of Helsinki is accepted as a policy by Marmara Medical Journal. Manuscripts which do not properly consider ethical issues for humans or

animals will not be accepted for publication. a) Marmara Medical Journal requires that investigations performed on human subjects have the prior approval of the institutional Committee on Human Experimentation. Authors are required to submit a signed statement as to the date and details of the appropriate review. b) When studies involve the use of experimental animals, manuscripts should briefly describe the procedures employed for animal care and handling. Where drugs are used at particular concentrations in intact animal systems, the author should indicate some rationale for selection of the particular concentration. Role of the Funding Source. All sources of funding should be declared as an acknowledgment at the end of the text. Conflict of Interest: All authors are required to disclose all potential conflicts of interests, including financial interests and relationships and affiliations (other than those listed in the title page of the manuscript) relevant to the subject of the manuscript. Also editors, all participants in the peer-review and publication process must disclose all relationships that could be viewed as potential conflicts of interests. (4) Authorship: Marmara Medical Journal asks the corresponding author to attest that the authors: a) had access to all the study data b) took responsibility for the accuracy of the analysis c) had the authority over manuscript preparation and the decision to submit the manuscript for publication. All manuscripts are examined by the editorial board and refereed critically by two or more reviewers, at least one from another institution. The editor reserves the right to reject or to return the manuscript to the author(s) for additional changes. A copyright release form will be sent automatically by e-mail once your article is received by the Editor.

Correspondence and communications regarding manuscripts and editorial material should be sent to: Seza Arbay Marmara Medical Journal Marmara University School of Medicine Tıbbiye cad. No: 49 Haydarpaşa 34668 İSTANBUL, TURKEY Phone: +90 216 4144734 Fax: +90 216 4144731 E-mail: mmj@marmara.edu.tr http://www.marmaramedicaljournal.org

Marmara Medical Journal Contents / Ä°Ă§indekiler

Marmara Ă&#x153;niversitesi TÄąp FakĂźltesi Dergisi Volume / Cilt 26 y Issue / SayÄą 2 y May / MayÄąs 2013

Reviews / Derlemeler

3HJYLVRPDQW WHGDYLVL VRQXoODUĂ&#x2022;PĂ&#x2022;] YH OLWHUDWÂ UÂ Q J|]GHQ JHoLULOPHVL The results of pegvisomant treatment in acromegaly and review of the literature

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Original Articles / Ă&#x2013;zgĂźn AraĹ&#x;tÄąrmalar

+DVWDneGe \DWDn KDVWDlDrGD KiSergliVePi VĂ&#x2022;klĂ&#x2022;ĂˇĂ&#x2022; Hyperglycemia in hospitalized patients

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$cil VerYiVWe KDVWD PePnuni\eWini eWkile\en IDkW|rlerin DrDĂşWĂ&#x2022;rĂ&#x2022;lPDVĂ&#x2022; The investigation of factors affecting the patient satisfaction in emergency services

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Case Reports / Olgu SunumlarÄą

,VolDWeG WuEDl WorVion in D ZoPDn ZKo KDG lDSDroVcoSic WuEDl ligDWion E\ EiSolDr electrocoagulation %ipolar elektrokoteri ile bilateral tuba ligasyonu olan kadĂ&#x2022;nda izole tubal torsiyon 7HYÂżN <ROGHPLU 0LWKDW (UHQXV

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Marmara Medical Journal 2013; 26:53-7 DOI: 10.5472/MMJ.2013.02698.1

DERLEME / REVIEW

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Marmara Medical Journal 2013; 26:58-62 DOI:10.5472/MMJ.2013. 02751.1

DERLEME / REVIEW

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Marmara Medical Journal 2013; 26:63-7 DOI:10.5472/MMJ.2013.02499.1

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Dilek ve ark. 63ยถOL oRFXNODUร Q DQQHOHULQGH GHSUHV\RQ YH \DรบDP NDOLWHVL

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Marmara Medical Journal

Marmara Üniversitesi M TTıp Fakültesi DDergisi

Volume / Cilt 26 - Issue / Sayı 2 - May/ Mayıs2013

Contents / İçindekiler Reviews / Derlemeler 53

Pegvisomant tedavisi sonuçlarımız ve literatürün gözden geçirilmesi The results of pegvisomant treatment in acromegaly and review of the literature Elif Kılıç Kan, Gülçin Cengiz Ecemiş, Çiğdem Tura Bahadır, Ayşegül Atmaca, Hulusi Atmaca, Ramis Çolak

58 63

Çocuk gelinler Child brides Perran Boran, Gülbin Gökçay, Esra Devecioğlu, Tijen Eren

Çoklu doğrusal regresyon sonuçlarının Jackknife tekniği ile tekrarlanabilirliğinin değerlendirilmesi Evaluating replicability of multiple linear regression results using the Jackknife technique

Nural Bekiroğlu, Rana Konyalıoğlu, Dilara Karahan

Original Articles / Özgün Araştırmalar 68

Hastanede yatan hastalarda hiperglisemi sıklığı Hyperglycemia in hospitalized patients

Muscarinic agonist, antagonists and signaling pathway inhibitors change c-Fos and cyclin D1 expression in K562 cells K562 hücrelerinde muskarinik agonist, antagonist ve sinyal ileti yolağı inhibitörleri c-Fos ve siklin D1 ekspresyonlarını değiştirir

Dilek Gogas Yavuz, Dilek Yazıcı, Sevim Özcan, Özlem Tarçın, Oğuzhan Deyneli, Sema Akalın

Hülya Cabadak, Banu Aydın, Beki Kan

The effect of prolonged time for achieving ovarian suppression before starting stimulation on pregnancy rates in ART cycles ART sikluslarında stimulasyona başlamadan önce uzamış ovaryen süpresyonun gebelik oranlarına etkisi Tevfik Yoldemir

Acil serviste hasta memnuniyetini etkileyen faktörlerin araştırılması The investigation of factors affecting the patient satisfaction in emergency services

S100B protein levels in patients admitted to an emergency service due to seizures Acil servise nöbet şikayeti ile başvuran hastalarda S100B protein düzeyi

Kerem Kabaroğlu, Serkan Emre Eroğlu, Özge Ecmel Onur, Arzu Denizbaşı, Haldun Akoğlu

Fatma Sarı Doğan, Arzu Denizbaşı Altınok, Özge Ecmel Onur, Özlem Güneysel, Haldun Akoğlu

Serebral palsili çocukların annelerinde depresyon ve yaşam kalitesinin değerlendirilmesi Assessment of depression and quality of life in mothers of children with cerebral palsy Banu Dilek, İbrahim Batmaz, Mehmet Karakoç, Mustafa Akif Sarıyıldız, Abdulkadir Aydın, Hüsamettin Çavaş, Remzi Çevik

Case Reports / Olgu Sunumları 99

Isolated tubal torsion in a woman who had laparoscopic tubal ligation by bipolar electrocoagulation Bipolar elektrokoteri ile bilateral tuba ligasyonu olan kadında izole tubal torsiyon

102

A case of foot drop secondary to a giant extraneural ganglion cyst close to the peroneal nerve Düşük ayağa yol açan, peroneal sinir komşuluğunda dev ekstranöral ganglion kisti olgusu

Tevfik Yoldemir, Mithat Erenus

Elif Ilgaz Aydınlar, Cihangir Tetik, Gökalp Silav, Behram Kaya, Serdar Özgen

105

Huntington hastalığına bağlı psikotik bozukluk ve tedaviye dirençli obsesif kompulsif bozukluk Treatment resistant obsessive compulsive disorder and psychosis due to Huntington’s disease Nurhan Fıstıkcı, Ömer Saatcioğlu, Evrim Erten, Görkem Yılmaz, Çağrı Çalcı, Ali Keyvan

Photo-Quiz 108

An old man with desquamative extensor skin lesions and periorbital changes Vitorino Modesto Dos Santos, Thiago Pereira Loures, Fabio Henrique De Oliveira Silva, Alessandra Maria Rodrigues Oliveira Santos, Kayursula Dantas De Carvalho