FACULTY PUBLICATIONS �������������������������������������������������������������������������������

6-month aerobic walking training increases T1w/ T2w signal in the white matter of healthy older

adults. (2020). Colmenares AM, Voss MW, Fanning J, Salerno EA, Gothe NP, Thomas ML, McAuley E, Kramer A, Burzynska AZ. medRxiv. https://doi. org/10.1101/2020.11.09.2022862

A systematic review of older adults’ request for or attitude toward euthanasia or assisted-suicide.

(2019). Dransart DAC, Lapierre S, Erlangsen A, Canetto SS, Heisel M, Draper B. Aging & Mental Health. https://doi.org/10.1080/13607863.2019.1697201

A temporal analysis of bilateral gait coordination

in people with multiple sclerosis. (2020). Richmond SB, Swanson CW, Peterson DS, Fling BW. Multiple Sclerosis and Related Disorders. https://doi. org/10.1016/j.msard.2020.102445

Aging and forgetting: Forgotten information is perceived as less important than is remembered

information. (2019). Witherby AE, Tauber SK, Rhodes MG, & Castel AD. Psychology and Aging. https://doi. org/10.1037/pag0000322

ATLAS: A Distributed File System for

Spatiotemporal Data. (2019). Rammer D, Pallickara SL, Pallickara S. Proceedings of the 12th IEEE/ACM International Conference on Utility and Cloud Computing. https://doi.org/10.1145/3344341.3368802

Augmentation of endothelium-dependent vasodilatory signalling improves functional sympatholysis in contracting muscle of older

adults. (2020). Hearon, C, Richards J, Racine M, Luckasen G, Larson D, & Dinenno, F. The Journal of Physiology. https://doi.org/10.1113/jp279462

Cannabidiol Induces Apoptosis and Perturbs Mitochondrial Function in both Human and

Canine Glioma Cells. (2020). Gross C, Ramirez D, Dickinson P, Gustafson D, McGrath S. FASEB Pharmacology. https://doi.org/10.1096/fasebj.2020.34. s1.04176

Cholinergic Synaptic Homeostasis Is Tuned by an NFAT-Mediated α7 nAChR-Kv4/Shal Coupled

Regulatory System. (2020). Eadaim A, Hahm ET, Justice ED, Tsunoda S. Cell Reports. https://doi. org/10.1016/j.celrep.2020.108119

Co-activation of selective nicotinic acetylcholine receptors is required to reverse beta amyloid–

induced Ca2+ hyperexcitation. (2019). Sun JL, Stokoe SA, Roberts JP, Sathler MF, Nip KA, Shou J, Ko K, Tsunoda S, Kim S. Neurobiology of Aging. https://doi. org/10.1016/j.neurobiolaging.2019.09.005

Cultural differences in coping with interpersonal tensions lead to divergent shorter- and longer-

term affective consequences. (2020). Luong G, Arredondo CM, & Charles ST. Cognition and Emotion. https://doi.org/10.1080/02699931.2020.1752153

Development of a play-based coaching intervention to improve quality of life and wellbeing for mothers with cancer and their young

children. (2020). Roman-Oyola R, Bundy A, Castro E, & Castrillo O. Journal of Clinical and Translational Science. https://doi.org/10.1017/cts.2020.121

Disrespect at Work, Distress at Home: A Longitudinal Investigation of Incivility Spillover

and Crossover Among Older Workers. (2020). Marchiondo LA, Fisher GG, Cortina LM, Matthews RA. Work, Aging and Retirement. https://doi. org/10.1093/workar/waaa007

Establishment of adult right ventricle failure in ovine using a graded, animal-specific pulmonary

artery constriction model. (2020). Nguyen-Truong, M, Liu, W, Boon, J, Nelson, B, Easley, J, Monnet, E, & Wang, Z. Animal Models and Experimental Medicine. https://doi.org/10.1002/ame2.12124

Evaluation of acupuncture for the treatment of pain associated with naturally-occurring osteoarthritis in dogs: a prospective, randomized,

placebo-controlled, blinded clinical trial. (2020). Baker-Meuten A, Wendland T, Shamir SK, Hess AM, & Duerr FM. BMC Veterinary Research. https://doi. org/10.1186/s12917-020-02567-1

Exploring Social Ecological Determinants of Physical Activity Among Adult Survivors of

Childhood Cancer. (2020). Dugan KF, Hidde MC, Chard CA, Graham DJ, Withycombe JS, & Leach HJ. Journal of Adolescent and Young Adult Oncology. https://doi.org/10.1089/jayao.2019.0169

Fall risk factors for individuals under the age of 65 years with type 2 diabetes mellitus.

(2020). Swink LA, Schmid AA, Atler KE, Klinedinst TC, Marchant TP, Marchant DR, Malcolm MP. British Journal of Occupational Therapy. https://doi. org/10.1177/0308022619876552

Functional Consequences of the Variable

Stoichiometry of the Kv1.3-KCNE4 Complex. (2020). Solé L, Sastre D, Colomer-Molera M, Vallejo-Gracia A, Roig SR, Pérez-Verdaguer M, Lillo P, Tamkun MM, Felipe A. Cells. https://doi.org/10.3390/cells9051128

Functional implications of impaired bimanual

force coordination in chronic stroke. (2020). Patel P, Lodha N. Neuroscience Letters. https://doi.org/10.1016/j. neulet.2020.135387.

Grandparent Caregivers’ Resilience: Stress, Support,

and Coping Predict Life Satisfaction. (2020). Mendoza AN, Fruhauf CA, MacPhee D. The International Journal of Aging and Human Development. https://doi. org/10.1177/0091415019843459

Health-related quality of life changes after the merging yoga and occupational therapy for Parkinson's disease program: A mixed-methods study.

(2020). Swink L, Fruhauf C, Atler K, Fling B, Klinedinst T, & Schmid A. Complementary Therapies in Clinical Practice. https://doi.org/10.1016/j.ctcp.2020.101156

Horticultural therapy support group for older adult caregivers: Examining intervention effectiveness

using psychometrically validated measures. (2019). Ascenio J, Wojtaszek M, & Davalos DB. The Journal of Therapeutic Horticulture. https://www.ahta.org/journal-oftherapeutic-horticulture-29-2---2019

Impact of a dementia-specific program of equine-

assisted activities: Providers’ perspectives. (2019). Fields B, Wood W, & Lassell R. Quality in Ageing and Older Adults. https://doi.org/10.1108/QAOA-10-2018-0047.

Impact of Red Beetroot Juice on Vascular Endothelial Function and Cardiometabolic Responses to a High-Fat Meal in Middle-Aged/Older Adults with Overweight and Obesity: A Randomized, Double-Blind, Placebo-

Controlled, Crossover Trial. (2019). Litwin NS, Van Ark HJ, Hartley SC, Michell KA, Vazquez AR, Fischer EK, Melby CL, Weir TL, Wei Y, Rao S, Hildreth KL, Seals DR, Pagliassotti MJ, Johnson SA. Current Developments in Nutrition. https://doi.org/10.1093/cdn/nzz113

Impaired force control contributes to car steering

dysfunction in chronic stroke. (2019). Patel P, Alam T, Tracy BL, & Lodha N. Disability and Rehabilitation. https:// doi.org/10.1080/09638288.2019.1685603

Incomplete glycosylation during prion infection unmasks a prion protein epitope that facilitates prion

detection and strain discrimination. (2020). Kang HE, Bian J, Kane SJ, Kim S, Selwyn V, Crowell J, Bartz JC, Telling GC. Journal of Biological Chemistry. https://doi. org/10.1074/jbc.RA120.012796

Lamin A/C deficiency enables increased myosin-II bipolar filament ensembles that promote divergent actomyosin network anomalies through self-

organization. (2020). Wiggan O, DeLuca JG, Stasevich TJ, Bamburg JR. Molecular Biology of the Cell. https://doi. org/10.1091/mbc.E20-01-0017-T

Leveraging elastic instabilities for amplified performance: Spine-inspired high-speed and high-

force soft robots. (2020). Tang Y, Chi Y, Su, J, Huang T, Maghsoudi O, Spence A, & Zhao J, et al. Science Advances. https://doi.org/10.1126/sciadv.aaz6912

Lipopeptide Delivery of siRNA to the Central Nervous

System. (2019). Zabel MD, Mollnow L, Bender H. Methods in Molecular Biology. https://doi.org/10.1007/978-1-49399092-4_26

Maternal Influenza A Virus Infection Restricts Fetal and Placental Growth and Adversely Affects the Fetal

Thymic Transcriptome. (2020). Van Campen H, Bishop JV, Abrahams VM, Bielefeldt-Ohmann H, Mathiason CK, Bouma GJ, Winger QA, Mayo CE, Bowen RA, Hansen TR. Viruses. https://doi.org/10.3390/v12091003

Measuring (Non)Essentialist Beliefs About the

Process of Aging. (2020). Weiss D & Diehl M. The Journals of Gerontology: Series B. https://doi.org/10.1093/ geronb/gbaa113

Measuring functional status of older adults with cancer with patient and performance-based measures, a how-to guide: A young society of geriatric oncology

and nursing and allied health initiative. (2020). Pergolotti M & Sattar S. Journal of Geriatric Oncology. https://doi.org/10.1016/j.jgo.2020.09.025

Merging Yoga and Occupational Therapy for Parkinson’s Disease: A Feasibility and Pilot Program.

(2020). Swink LA, Fling BW, Sharp JL, Fruhauf CA, Atler KE, & Schmid AA. Occupational Therapy in Health Care. https://doi.org/10.1080/07380577.2020.1824302

FACULTY PUBLICATIONS

Metformin enhances protection in guinea pigs chronically infected with Mycobacterium

tuberculosis. (2020). Frenkel JDH, Ackart DF, Todd AK, DiLisio JE, Hoffman S, Tanner S, Kiran D, Murray M, Chicco A, Obregón-Henao A, Podell BK, & Basaraba RJ. Scientific Reports. https://doi.org/10.1038/s41598020-73212-y

Metrics of Diabetes Risk Are Only Minimally Improved by Exercise Training in Postmenopausal

Breast Cancer Survivors. (2020). Viskochil R, Blankenship JM, Makari-Judson G, Staudenmayer J, Freedson PS, Hankinson SE, Braun B. The Journal of Clinical Endocrinology & Metabolism. https://doi. org/10.1210/clinem/dgz213

Microbial metabolite indole-3-propionic acid supplementation does not protect mice from the cardiometabolic consequences of a Western diet.

(2020). Lee DM, Ecton KE, Trikha SRJ, Wrigley SD, Thomas KN, & Battson ML, Wei Y, Johnson SA, Weir TL, & Gentile CL. American Journal of PhysiologyGastrointestinal and Liver Physiology. https://doi. org/10.1152/ajpgi.00375.2019

Natural and pathogenic protein sequence variation affecting prion-like domains within and across

human proteomes.(2020). Cascarina S & Ross ED. BMC Genomics. https://doi.org/10.1186/s12864-0196425-3

Network Simulations Reveal Molecular Signatures of Vulnerability to Age-Dependent Stress and Tau

Accumulation. (2020). Hoffman TE, Hanneman WE, & Moreno JA. Frontiers Molecular Biosciences. https:// doi.org/10.3389/fmolb.2020.590045

NF-ϰB Signaling in Astrocytes Modulates Brain Inflammation and Neuronal Injury Following Sequential Exposure to Manganese and MPTP

During Development and Aging. (2020). Hammond SL, Bantle CM, Popichak KA, Wright KA, Thompson D, Forero C, Kirkley KS, Damale PU, Chong EKP, Tjalkens RB. Toxicological Sciences. https://doi.org/10.1093/ toxsci/kfaa115

Occupational Physical Stress Is Negatively Associated With Hippocampal Volume and

Memory in Older Adults. (2020). Burzynska, AZ, Ganster DC, Fanning J, Salerno EA, Gothe NP, Voss MW, McAuley E, & Kramer AF. Frontiers Human Neuroscience. https://doi.org/10.3389/ fnhum.2020.00266

Parkin sarcopenia in its tracks by improving

mitochondrial health. (2019). Estrada A, Valenti Z, & Lark D. The Journal of Physiology. https://doi. org/10.1113/jp277641

Participation Is Associated With Well-Being Among Community-Based Veterans: An Investigation of Coping Ability, Meaningful Activity, and Social Support as Mediating

Mechanisms. (2020). Kinney A, Graham J, & Eakman A. American Journal of Occupational Therapy. https:// doi.org/10.5014/ajot.2020.037119

Reactive Oxygen Species Modulate ActivityDependent AMPA Receptor Transport in C.

elegans. (2020). Doser Rl, Amberg GC, Hoerndli FJ. Journal of Neuroscience. https://doi.org/10.1523/ JNEUROSCI.0902-20.2020

RT-QuIC detection of tauopathies using full-

length tau substrates. (2020). Tennant JM, Henderson DM, Wisniewski TM, Hoover EA. Prion. https://doi.org/10.1080/19336896.2020.1832946

Sex differences in changes of protein synthesis with rapamycin treatment are minimized when

metformin is added to rapamycin. (2020). Wolff CA, Lawrence MM, Porter H, Zhang Q, Reid JJ, Laurin JL, Musci RV, Linden MA, Peelor FF 3rd, Wren JD, Creery JS, Cutler KJ, Carson RH, Price JC, Hamilton KL, Miller BF. GeroScience. https://doi.org/10.1007/s11357-02000243-8

Short-term time-restricted feeding is safe and feasible in non-obese healthy midlife and older

adults. (2020). Martens CR, Rossman MJ, Mazzo MR, Jankowski LR, Nagy EE, Denman BA, Richey JJ, Johnson SA, Ziemba BP, Wang Y, Peterson CM, Chonchol M, Seals DR. GeroScience. https://doi. org/10.1007/s11357-020-00156-6

Single-Molecule Navigation of the Nucleosomal

Transcription Landscape. (2020). Chen Z, Gabizon R, Yao T, Bustamante C. Biophysical Journal. https://doi. org/10.1016/j.bpj.2019.11.2968

Sodium Glucose Co-Transporter 2 Inhibition Does Not Favorably Modify the Physiological Responses to Dietary Counselling in Diabetes-Free, Sedentary

Overweight and Obese Adult Humans. (2020). Ryan SP, Newman AA, Wilburn JR, Rhoades LD, Trikha SRJ, Godwin EC, Schoenberg HM, Battson ML, Ewell TR, Luckasen GJ, Biela LM, Melby CL, Bell C. Nutrients. https://www.mdpi. com/2072-6643/12/2/510/htm

The Dunkin Hartley Guinea Pig Is a Model of Primary Osteoarthritis That Also Exhibits Early Onset Myofiber Remodeling That Resembles Human

Musculoskeletal Aging. (2020). Musci RV, Walsh MA, Konopka AR, Wolff CA, Peelor FF 3rd, Reiser RF 2nd, Santangelo KS, Hamilton KL. Frontiers Physiology. https:// doi.org/10.3389/fphys.2020.571372

The gut microbiome–derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with

aging. (2020). Brunt VE, LaRocca TJ, Bazzoni AE, et al. GeroScience. https://doi.org/10.1007/s11357-020-00257-2

The NASA Twins Study: A multidimensional analysis

of a year-long human spaceflight. (2019). GarrettBakelman FE, Darshi M, Green SJ, Gur RC, Lin L, Macias BR, McKenna MJ, Meydan C, Mishra T, Nasrini J, Piening BD, Rizzardi LF, Sharma K, Siamwala JH, Taylor L, Vitaterna MH, Afkarian M, Afshinnekoo E, Ahadi S, Ambati A, Arya M, Bezdan D, Callahan CM, Chen S, Choi AMK, Chlipala GE, Contrepois K, Covington M, Crucian BE, De Vivo I, Dinges DF, Ebert DJ, Feinberg JI, Gandara JA, George KA, Goutsias J, Grills GS, Hargens AR, Heer M, Hillary RP, Hoofnagle AN, Hook VYH, Jenkinson G, Jiang P, Keshavarzian A, Laurie SS, Lee-McMullen B, Lumpkins SB, MacKay M, Maienschein-Cline MG, Melnick AM, Moore TM, Nakahira K, Patel HH, Pietrzyk R, Rao V, Saito R, Salins DN, Schilling JM, Sears DD, Sheridan CK, Stenger MB, Tryggvadottir R, Urban AE, Vaisar T, Van Espen B, Zhang J, Ziegler MG, Zwart SR, Charles JB, Kundrot CE, Scott GBI, Bailey SM, Basner M, Feinberg AP, Lee SMC, Mason CE, Mignot E, Rana BK, Smith SM, Snyder MP, Turek FW. Science. https://science.sciencemag.org/ content/364/6436/eaau8650

The platelet-rich plasma and mesenchymal stem cell milieu: A review of therapeutic effects on bone

healing. (2020) Liebig BE, Kisiday JD, Bahney CS, Ehrhart NP, Goodrich LR. Journal of Orthopaedic Research. https:// doi.org/10.1002/jor.24786

The Relationship of Employment Scarcity and Perceived Threat With Ageist and Sexist Attitudes.

(2019). Ospina JH, Cleveland JN, Gibbons AM. Work, Aging and Retirement. https://doi.org/10.1093/workar/waz003

Using Grounded Theory to Inform the HumanCentered Design of Digital Health in Geriatric

Palliative Care. (2020). Portz JD, Ford KL, Doyon K, Bekelman D, Boxer RS, Kutner JS, Czaja S, Bull S. Journal of Pain and Symptom Management. https://doi.org/10.1016/j. jpainsymman.2020.06.027

Using intraindividual variability as an indicator of cognitive improvement in a physical exercise intervention of older women with mild cognitive

impairment. (2020). Brydges CR, Liu-Ambrose T, Bielak AAM. Neuropsychology. https://doi.org/10.1037/ neu0000638

Vasoactive intestinal peptide regulates ileal goblet cell

production in mice. (2020) Schwerdtfeger LA & Tobet SA. Physiological Reports. https://doi.org/10.14814/phy2.14363

Yoga improves balance, mobility, and perceived occupational performance in adults with chronic

brain injury: A preliminary investigation. (2020) Stephens JA, Van Puymbroeck M, Sample PL, Schmid AA. Complementary Therapies in Clinical Practice. https://doi. org/10.1016/j.ctcp.2020.101172

ROAD MAP TO THE FUTURE

The Center’s Top Growth Priorities

Next 1-3 Years

CORE 1: Transdisciplinary Research

♦ Expand comparative aging research opportunities (basic and applied). ♦ Develop a longitudinal biospecimen and data management core for aging biomarker discovery. ♦ Build and maintain a robust research participant registry. ♦ Engage faculty through an official membership agreement. ♦ Recruit additional core faculty. CORE 2: Educational Opportunities

♦ Obtain “Special Academic Unit” status in order to provide aging-related courses and credits. ♦ Submit a federal training grant proposal to provide funding for predoctoral and postdoctoral research training and support for innovative exploratory and developmental research. ♦ Apply for “Age-Friendly University” designation for CSU. ♦ Create an interdisciplinary online educational degree in clinical research management. ♦ Launch certificate programs that supplement students’ and community members’ skills and training. ♦ Facilitate summer capstone projects for M.D., D.V.M., and Ph.D. students in interdisciplinary aging studies ♦ Launch the Interdisciplinary Aging Research Mentored

Pilot Grant Program.

CORE 3: Community Engagement

♦ Create and engage an external advisory board. ♦ Expand reach at state and national levels. ♦ Continue to increase presence within local organizations focused on serving older adults. ♦ Launch the living healthy longer podcast and expand communications. ♦ Develop an interdisciplinary doctoral program in aging studies, providing Ph.D. students an opportunity to create a degree of their own design. ♦ Create an assisted living/retirement community on CSU’s Main Campus, providing a state-of-theart living-learning experience that benefits both

CSU faculty and students, as well as older adults in Fort Collins.

Stretch Goals

5+ Years from Now

CORE 4: Finances + Philanthropy

♦ Forge external partnerships with foundations and industries to elevate aging research and programming within the Center. ♦ Seek prospective donors for translational and comparative research. ♦ Create growth opportunities through clinical trials, longitudinal biobanking, and industry partnerships.

Diversity, Equity, and Inclusion Statement

The Columbine Health Systems Center for Healthy Aging strives to uphold CSU’s Principles of Community. We embrace diversity, equity, and inclusivity across race, gender, ethnicity, religion, identity, ability, culture, and age. As a new Center, we seek to build a culture that encourages, supports, and celebrates diverse perspectives and where all people feel empowered to be their authentic selves.

Make an IMPACT

on the future of healthy aging 

Your gift to the Columbine Health Systems Center for Healthy Aging at Colorado State University promotes successful, healthy aging for adults across the Front Range and beyond. With your donation, you enable research, education, and community outreach to create and share innovative, interdisciplinary solutions to the challenge of global population aging.

Gifts can be general in nature or dedicated to any activity listed in the annual report. If interested in donating, contact Director of the Center for Healthy Aging, Nicole Ehrhart, at nicole.ehrhart@colostate.edu. Thank you for considering a donation.