AN AK APPROACH TO KREBS CYCLE DYSFUNCTION AND BEYOND

Taking it beyond the Krebs cycle we can see that it is necessary to look at the effects of ATP production and other byproducts such as Glutamate, GABA, and Adenosine

Adenosine is essential for proper function of every cell in the body It is important to know that ATP acts as an excitatory co-transmitter with norepinephrine and Adenosine as an inhibitory neurotransmitter ATP gets metabolized to Adenosine with a hydrolysis reaction and Magnesium as a cofactor

When awake Adenosine rises by the hour resulting in the desire to sleep or sleep pressure If Krebs cycle dysfunction is corrected and the patient becomes more irritable or doesn’t feel like sleeping Magnesium supplementation may be necessary to move from ADP to Adenosine as indicated below And finally, Adenosine has an anti-nociceptive effect and well as dilates coronary arteries

If Krebs cycle dysfunction is corrected and the patient is much calmer and anxiety has decreased, you can assume that more GABA is being formed. If there is increased anxiety and agitation as well as poor sleep, Glutamate may not be converting to GABA. If this is the case B6 and P-5-P should be considered as indicated below.