CHRONIC MYELOID LEUKAEMIA CAUSES | SYMPTOMS | TREATMENT
INTRODUCTION TO CHRONIC MYELOID LEUKAEMIA
Chronic myelogenous leukemia is a pluripotent stem cell disease characterized by anaemia, extreme blood granulocytosis with immaturity, basophilia, thrombocytosis and splenomegaly. The haemtopoietic cell contain a reciprocal translocation between chromosome 9 and 22 known as the philadelphia choromosome. Occurs more often in men. Disease of firsts High doses of ionising radiation can increaser the occurrence of CML.
SIGN AND SYMPTOMS OF CHRONIC MYELOID LEUKAEMIA Signs and symptoms of chronic myeloid leukaemia may include: Easy bleeding Feeling run-down or tired Fever
Losing weight without trying
Loss of appetite
Pain or fullness below the ribs on the left side Pale skin Sweating excessively during sleep (night sweats)
TESTS AND DIAGNOSIS FOR CHRONIC MYELOID LEUKAEMIA After you have shown the signs and symptoms of chronic myeloid leukaemia, your doctor may suggest the following tests and procedures:
Physical exam: Your doctor will perform a complete physical examination to check pulse and blood pressure. He/she will also feel your lymph nodes, spleen and abdomen for any irregularities. Blood tests: A complete blood count may reveal abnormalities in your blood cells. Your doctor may also perform blood chemistry tests to measure organ function.
CONTINUE :- TESTS AND DIAGNOSIS FOR CHRONIC MYELOID LEUKAEMIA
Bone marrow tests: Bone marrow biopsy and bone marrow aspiration are used to collect bone marrow samples for laboratory testing. These tests involve collecting bone marrow from your hipbone.
Tests to look for the Philadelphia chromosome: A detailed lab test of your genes, called fluorescence in situ hybridization (FISH) is done to measure the number of cells containing the Philadelphia chromosome .
AVAILABLE TREATMENTS FOR CHRONIC MYELOID LEUKAEMIA
Targeted drugs: Targeted drugs such as Gleevec, Sprycel, Tasigna, and Bosulif are designed to attack cancer by focusing on a particular aspect of cancer cells that allows them to grow and multiply. In chronic myeloid leukaemia, the target of these drugs is the protein produced by the abnormal BCR-ABL gene. Bone marrow transplant: Also known as a blood stem cell transplant, it offers the only chance for a definitive cure for chronic myeloid leukaemia. In the process, high doses of chemotherapy drugs are used to kill the blood-forming cells in your bone marrow. They are then replaced by blood stem cells from a donor which are infused into your bloodstream.
CONTINUE :- AVAILABLE TREATMENTS FOR CHRONIC MYELOID LEUKAEMIA
Chemotherapy: Chemotherapy drugs are typically combined with other treatments for chronic myeloid leukaemia. Often, chemotherapy treatment for chronic myelogenous leukaemia is given as a tablet you take orally.
Biological therapy: Biological therapies strengthen your body's immune system to help fight cancer. This option is successful for those patients who can't take other drugs or when other treatments fail.
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