2009– 2010 Raman Products Catalog
www.laser2000.com
GER/AT/CH Laser 2000 GmbH 82234 Wessling Tel. +49 8153 405-0 info@laser2000.de www.laser2000.de
France Laser 2000 SAS 78860 St-N. l. Bretèche Tel. +33 1 30 80 00 60 info@laser2000.fr www.laser2000.fr
Iberia Laser 2000 SAS 50002 Zaragoza Tel. +34 976 299-150 info@laser2000.es www.laser2000.es
Nordics Laser 2000 GmbH 82234 Wessling Tel. +46 73 524 2745 info@laser2000.se www.laser2000.se
BaySpec, Inc. Founded in 1999 with support from some of the leading corporations and venture capital firms in the Silicon Valley, BaySpec is a vertically integrated spectral sensing company. The company designs, manufactures and markets advanced spectral instruments, from UV-VIS spectrometers to handheld and portable NIR and Raman analyzers, for the biomedical, pharmaceuticals, chemical, food, semiconductor, homeland security, and the optical telecommunications industries.
Engineering and Product Development A team of experienced and dedicated optical, electrical, mechanical, and software engineers
Shortest product development cycle in the industry
Extensive Intellectual Property covering key aspects of our products
In-house capabilities encompassing all the important and critical components, from lasers to gratings and state-of-the-art detectors
Production
Multi-million dollar, 22,000 square feet production facility, including 2,000 square feet Class 100 clean room space
100% made in the USA
Quality Control Dedicated team, established procedures to ensure consistent and reliable product delivery
Safety and Environment At BaySpec the safety of our employees and customers is our utmost concern. Rigorous training programs are implemented for laser, electrical, and hazardous materials safety. For all the products that we release, they are extensively reviewed for any potential safety hazard and every precaution is exercised, whether via hardware design or software control, to prevent safety issues from occurring. BaySpec is committed to green manufacturing techniques and processes. We strive to minimize or eliminate the use of hazardous materials in every manufacturing step, thus benefitting the health and well being of our employees and the environment. Our spectral sensing products are compact and energy efficient and do not generate hazardous waste during normal usage.
Table of Contents
Why Raman? and Why Now?
4
The BaySpec Advantage
5
XantusTM-0 Raman Analyzer
6
XantusTM-1 Raman Analyzer
8
XantusTM-1G Raman Analyzer
10
XantusTM-2 Raman Analyzer
12
PortabilityTM-1 Raman Analyzer
14
RamSpecTM-1 Raman Analyzer
16
NomadicTM Raman Microscope
18
Customized Instruments
20
OEM Partnership
20
Accessories for Raman Analyzers
21
Software: Micro 20/20
22
Applications of Raman Spectroscopy
24
Raman Analyzer Selection Guide
26
Why Raman? and Why Now? A Primer on Raman Spectroscopy The Raman effect occurs when light impinges upon a molecule and interacts with the electron cloud that binds that molecule. While most of the incident light is scattered with its wavelength unchanged (i.e., elastically scattered), a small fraction (on the order of 10 -6) of the light is inelastically scattered and exits with longer wavelength and simultaneously promote the molecule into a more energetic vibrational state. An even smaller fraction of the light picks up energy from the molecule and leaves with a shorter wavelength. This effect was named after one of its discoverers, Sir C. V. Raman, who, in 1928, accomplished his observation with sunlight and filters. A change in the molecular polarizability — or deformation of the electron cloud — with respect to the vibrational coordinate is required for the molecule to exhibit the Raman effect. The amount of the polarizability change will determine the Raman scattering intensity, whereas the shift in wavelength (called the Raman shift) is equal to the vibrational level that is involved. When the shift is to longer wavelength it is called the Stokes shift, and when it is to shorter wavelength it is called the antiStokes shift. The location and intensity of the Raman lines are determined by the underlining molecular structure and are unique to the molecule and its environment, thus the Raman spectrum bears a molecular spectral finger print. For Raman spectroscopy both excitation and detection are achieved in the visible or near-infrared range, but the obtained spectral information is in the infrared range (difference between excitation and detection). Detection of light in the visible/near infrared is generally much easier than in the infrared since it is less susceptible to thermal noise. Raman spectroscopy is a powerful analytical technique owning to its nondestructive nature and simplicity in sample preparation and handling. However, its full potential could not be reached until now. The reasons may be traced back to Sir C. V. Raman’s original observations made in 1928; in his Communications to Nature he commented on the effect’s ―excessive feebleness‖ and the need for ―very powerful illumination‖. Lasers, invented in the 1960’s, certainly qualified as ―powerful illumination‖ sources. However, for a long time lasers were bulky, A laser Raman spectrometer from mid-1980s expensive, and required experts to operate. Sensitive detectors and other optical components such as line-ruled gratings were also scarce and expensive. Thus Raman spectrometers were reserved for sophisticated scientific research and not accessible for routine analytical applications.
Why Now? In the late 1990’s the buildup of the optical telecommunications infrastructure brought down price barriers for many lasers while reducing their physical dimensions. Holographic optical components are also much more accessible than before. Together with compact yet powerful computers/microprocessors high performance Raman spectrometers can be made in portable, even handheld, form factors at a fraction of the cost of traditional research instruments today. A handheld Raman spectrometer from BaySpec The time for Raman is NOW.
4
BaySpec, Inc. | 101 Hammond Ave., Fremont, California 94539 USA | : 1.510.661.2008 |: 1.510.661.2009 | www.bayspec.com
The BaySpec Advantage Volume Phase Grating (VPG®) Central to any dispersive spectrometer is the grating, the dispersive element. Transmission VPGs offer generally higher efficiencies than traditional reflective gratings. For low signal applications this is a significant performance edge. BaySpec’s Raman spectrometers are equipped with VPGs so that they have higher optical throughput than similar products on the market. These VPGs are designed and manufactured on site at BaySpec. The spectral coverage of the spectrometers is solely dictated by customers’ needs and not limited by the availability of gratings from third party vendors.
VPG®s manufactured at BaySpec
Schematic Diagram of a NIR Dispersive Spectrometer based on a Transmissive Holographic Volume Phase Grating (VPG®)
Right Detector for the Right Job BaySpec offers a complete line of array detectors in the visible and near infrared that are sensitive to 1700 nm, 2200 nm, or 2500 nm. Noise from dark currents is a challenging issue for NIR detectors, especially when the spectral range is extended to midIR. To ensure exceptional signal to noise ratio in every spectral range, BaySpec’s detectors run either athermally, or thermoelectrically cooled to –20 °C. For even more demanding applications the detector array can be cooled to –55 °C.
2009 BaySpec, Inc.; VPG is a registered trademark of BaySpec; Nomadic, Portability, RamSpec, and Xantus are commercial trademarks of BaySpec.
5
XantusTM-0 Raman Analyzer Palm sized
Reliable
Ruggedized
Battery-operated
Ideal for:
Chemical solvents identification
In-line/at-line sensors
Field inspections
Surface Enhanced Raman (SERS)
Teaching labs
Quality Control/Assurance
With a footprint approximately a third of a composition book and weighing than 2 lbs, Xantus TM-0 is an affordable, yet complete Raman spectrometer. It is available in two versions, one connected to a smart phone for remote wireless operation and one integrated with a Personal Digital Assistant (PDA). In addition to on-board data processing functions, the XantusTM-0 can transmit data to centralized facilities via cellular or WiFi networks, thus enabling real time communication and decision making in mission critical situations.
Tailored for Raman Each XantusTM-0 is equipped with a 785 nm laser stabilized for Raman spectroscopy. Output power: >80 mW. Linewidth: 0.2 nm FWHM typical.
Pyridine @ 1 s integration time
At the heart of every XantusTM-0 is a transmissive VPG that delivers unsurpassed optical throughput. The spectrograph is customized to cover the 500 – 1800 cm-1 range which is the most chemically informative spectral region, thus leaving no pixels wasted. The detector is a 1024 element CCD array that delivers high sensitivity cost effectively. XantusTM-0 runs on BaySpec’s Micro 20/20 software that has an intuitive, streamlined user interface and can output data in .csv format for easy importing to other applications. Baseline correction function is intelligently built in, which greatly facilities reduction in fluorescence interference and account for drift in background.
600
800
1000
1200
1400
1600
-1
Raman Shift (cm )
XantusTM-0 not only has no moving parts but also has its sensitive optical engine shock-resistant mounted, resulting in a ruggedized instrument that has withstood the rigors of field testing.
6
BaySpec, Inc. | 101 Hammond Ave., Fremont, California 94539 USA | : 1.510.661.2008 |: 1.510.661.2009 | www.bayspec.com
XantusTM-0 Raman Analyzer Xantus: a hummingbird species native to Baja Califor-
Bring Instrumentation to the Sample
nia and often spotted on the California coast.
Hum-
mingbirds are among the smallest of birds, can hover in mid-air by flapping their wings 12-90 times per second and fly at speeds exceeding 15 m/s (54 km/h, 34 mi/h). Xantus has a wide spectral vision up to near-UV.
TM
The Xantus -0 can perform measurements either via direct focusing or through a vial holder. For hard to reach spaces where a fiber collection bundle is more appropriate a fiber optic adapter is available.
Specifications
TM
The Xantus -0 can handle samples in liquid, gel, powder, or solid forms, under laboratory conditions, or field environments, thus fulfilling the promise of bring instrument to the sample. Part Number
HRAM-0A-0785
HRAM-0B-0785
Size Dimensions (mm3)
85 x 190 x 50
95 x 195 x 60
Weight
1 kg (2.2 lbs.)
1.5 kg (3 lbs.)
Excitation Source Wavelength
785 nm
Bandwidth
0.2 nm typ./ 0.3 nm max. (FWHM)
Output power
~80 mW
Spectrograph
Gasoline
50-50
Grating technology
Transmission Volume Phase Grating (VPG®)
Range (785nm)
500-1800 cm-1
Spectral resolution
~15-17 cm-1
Stray light rejection
0.05%
Detector
Methanol
Type
CCD
Number of pixels
1024
Pixel size
14 µm
Cooling temperature
Ambient
Integration time
0 - 300 sec.
Readout speed
250 kHz
Digitalized output
16-bit
Dynamic range
2000:1 typ.
Quantum Efficiency (max.)
>90%
Electronics
600
800
1000
1200
1400
1600
1800
-1
Raman Shift (cm )
Raman spectra of gasoline, methanol, and their 50-50 mixture
Interface
USB 2.0
Input power
Battery operated
Trigger mode
5 V TTL edge or level (optional)
Battery life
4 hrs
Software GUI
Micro 20/20 for Windows CE
SDK
N/A
Spectral libraries
User built
2009 BaySpec, Inc.; VPG is a registered trademark of BaySpec; Nomadic, Portability, RamSpec, and Xantus are commercial trademarks of BaySpec.
7
XantusTM-1 Raman Analyzer Handheld
Reliable
Ruggedized
Battery-operated
Ideal for:
Incoming materials inspection
Gemstone authentication
Mineral identification
Food safety evaluation
Narcotics & drugs
Teaching labs
Quality Control/Assurance
With a laser that is capable of delivering 500 mW of power and a thermoelectrically cooled CCD array detector, Xantus TM -1 is a high performance Raman spectrometer in an ultra compact package. It can accomplish some of the most challenging analytical tasks traditionally reserved for research grade instruments, while field ready with no need for external power or cooling. In addition to on-board data processing functions, the XantusTM –1 can transmit data to centralized facilities via WiFi networks, thus enabling real-time communication and decision making in mission critical situations.
Tailored for Raman Each XantusTM -1 is equipped with a 785 nm laser stabilized for Raman spectroscopy. Output power: >500 mW. Linewidth: 0.2 nm FWHM typical.
Cyclohexane @ 1 s integration time
At the heart of every XantusTM -1 is a transmissive VPG that delivers unsurpassed optical throughput. The spectrograph is customized to cover the 500 – 1800 cm-1 range which is the most chemically informative spectral region, thus leaving no pixels wasted. The detector is a 1024 element CCD array thermoelectrically cooled to – 20 °C that drastically reduces dark currents and delivers superior signal to noise ratios. XantusTM -1 runs on BaySpec’s Micro 20/20 software that has an intuitive, streamlined user interface and can output data in .txt, .csv, or .spc format. Baseline correction function is intelligently built in, which greatly facilities reduction in fluorescence interference and account for drift in background.
600
800
1000
1200
1400
1600
-1
Raman Shift (cm )
XantusTM -1 not only has no moving parts but also has its sensitive optical engine shock-resistant mounted, resulting in a ruggedized instrument that has withstood the rigors of field testing. 8
BaySpec, Inc. | 101 Hammond Ave., Fremont, California 94539 USA | : 1.510.661.2008 |: 1.510.661.2009 | www.bayspec.com
XantusTM-1 Raman Analyzer Bring Instrumentation to the Sample The XantusTM -1 can perform measurements either via direct focusing or through a vial holder. For hard to reach spaces where a fiber collection bundle is more appropriate a fiber optic adapter is available. The XantusTM -1 can handle samples in liquid, gel, powder, or solid forms, under laboratory conditions, or field environments, thus fulfilling the promise of bring instrument to the sample.
785 nm laser spectrum
Specifications Part Number
HRAM-1-0785
Size Dimensions (mm3)
125 x 223 x 85
Weight
2.4 kg (4.7lbs.)
Excitation Source Wavelength
785 nm
Bandwidth
0.2 nm typ./ 0.3 nm max. (FWHM)
Output power
100 - 500 mW
Spectrograph Grating technology
Transmission Volume Phase Grating (VPG®)
Range (785nm)
500-1800 cm-1
Spectral resolution
~10-12 cm-1
Stray light rejection
0.05%
Detector Type
fatty tissue (net)
fatty tissue + background
background
TE cooled CCD
Number of pixels
1024
Pixel size
14 µm
Cooling temperature
-20°C
Integration time
0 - 300 sec.
Readout speed
250 kHz
Digitalized output
16-bit
Dynamic range
3000:1 typ.
Quantum Efficiency (max.)
>90%
Electronics Interface
USB 2.0
Input power
Battery operated
Trigger mode
5 V TTL edge or level (optional)
Battery life
4 hrs
Software
600
800
1000
1200
Raman Shift (cm
1400
1600
-1
)
1800
GUI
Micro 20/20 for Windows
SDK
DLL, Sample Codes for VC and LabVIEW
Spectral libraries
User built or 3rd party (optional)
Raman spectrum from fatty tissue
2009 BaySpec, Inc.; VPG is a registered trademark of BaySpec; Portability, Nomadic, RamSpec, and Xantus are commercial trademarks of BaySpec.
9
XantusTM-1G Raman Analyzer Handheld
Reliable
Ruggedized
Battery-operated
Ideal for:
Narcotics & drugs
Explosives detection
Incoming/Outgoing materials inspection
Mineral/gemstone identification
Food safety evaluation
Teaching labs
Quality Control/Assurance
With a laser that is capable of delivering 500 mW of power and a thermoelectrically cooled CCD array detector, Xantus TM -1G is a high performance Raman spectrometer in an ultra compact package. It can accomplish some of the most challenging analytical tasks traditionally reserved for research grade instruments, while field ready with no need for external power or cooling. With an active trigger built into the ergonomically designed handle, XantusTM-1G allows single hand operation, ideal for front line personnel in law enforcement and emergency responding teams. In addition to on-board substance identification functions, the XantusTM –1G can transmit data to centralized facilities via WiFi networks, thus enabling real-time communication and decision making in mission critical situations.
Tailored for Raman Each XantusTM -1G is equipped with a 785 nm laser stabilized for Raman spectroscopy. Output power: >500 mW. Linewidth: 0.2 nm FWHM typical. At the heart of every XantusTM -1G is a transmissive VPG that delivers unsurpassed optical throughput. The spectrograph is customized to cover the 400 – 1700 cm-1 range which is the most chemically informative spectral region, thus leaving no pixels wasted. The detector is a 1024 element CCD array thermoelectrically cooled to –20 °C that drastically reduces dark currents and delivers superior signal noise ratios.
to
XantusTM -1G runs on BaySpec’s Veri-ID software that has an intuitive, streamlined user interface and can perform rapid and accurate library searches and identify completely unknown substances without user input. For experienced users spectral data can be exported and accessed in .txt, .csv, or .spc format. Baseline correction function is intelligently built in, which greatly facilities reduction in fluorescence interference and account for drift in background.
XantusTM -1G not only has no moving parts but also has its sensitive optical engine shock-resistant mounted, resulting in a ruggedized instrument that has withstood the rigors of field deployment.
10
BaySpec, Inc. | 101 Hammond Ave., Fremont, California 94539 USA | : 1.510.661.2008 |: 1.510.661.2009 | www.bayspec.com
XantusTM-1G Raman Analyzer Bring Instrumentation to the Sample The XantusTM -1G can perform measurements through various packages/containers, such as plastic bags, glass vials, and even brown glass bottles. The XantusTM -1G can handle samples in liquid, gel, powder, or solid forms, under laboratory conditions, or field environments, thus fulfilling the promise of bring instrument to the sample. It does not destroy or touch the sample. For most samples they can be measured and identified as “they are”, no preparation/pre-treatment is needed.
Specifications Part Number
HRAM-1-0785
Size Dimensions (mm3)
125 x 223 x 85*
Weight
2.7 kg (6 lbs.)
Excitation Source Wavelength
785 nm
Bandwidth
0.2 nm typ./ 0.3 nm max. (FWHM)
Output power
100 - 500 mW
Spectrograph Grating technology
Transmission Volume Phase Grating (VPG®)
Range (785nm)
500-1800 cm-1
Spectral resolution
~10-12 cm-1
Stray light rejection
0.05%
Detector
Motrin
Tylenol
800
1000
TE cooled CCD 1024
Pixel size
14 µm
Cooling temperature
-20°C
Integration time
0 - 300 sec.
Readout speed
250 kHz
Digitalized output
16-bit
Dynamic range
3000:1 typ.
Quantum Efficiency (max.)
>90%
Electronics
Aspirin
600
Type Number of pixels
Interface
USB 2.0
Input power
Battery operated
Trigger mode
5 V TTL edge or level (optional)
Battery life
4 hrs
Software
1200
1400
1600
GUI
Micro 20/20 for Windows
SDK
DLL, Sample Codes for VC and LabVIEW
Spectral libraries
User built or 3rd party (optional)
-1
Raman shift (cm ) Raman spectra of common pain killers
*Not including the handle
2009 BaySpec, Inc.; VPG is a registered trademark of BaySpec; Portability, Nomadic, RamSpec, and Xantus are commercial trademarks of BaySpec.
11
XantusTM-2 Raman Analyzer Portable
Reliable
Ruggedized
Battery-operated
Ideal for:
Biomedical samples
Algae
Fluorescence suppression
Narcotics & drugs
Teaching labs
Quality Control/Assurance
The XantusTM -2 is the only portable dispersive Raman spectrometer with 1064 nm excitation on the market today. It performs virtually fluorescence free Raman measurements with a powerful 1064 nm laser (>500 mW) and a thermoelectrically cooled 512 pixel InGaAs array detector (< -50 °C). In addition to on-board data processing functions, the XantusTM -2 can transmit data to centralized facilities via WiFi networks, thus enabling real time communication and decision making in mission critical situations.
Tailored for Raman Each XantusTM-2 is equipped with a 1064 nm laser stabilized for Raman spectroscopy. Output power: >500 mW. Linewidth: 0.2 nm FWHM typical.
Pyridine @ 10 s integration
At the heart of every XantusTM-2 is a transmissive VPG that delivers unsurpassed optical throughput. The spectrograph is customized to cover the 250 – 2100 cm-1range which is the most chemically informative spectral region, thus leaving no pixels wasted. The detector is a 512 element InGaAs array thermoelectrically cooled to –50 °C that drastically reduces dark currents and delivers superior signal to noise ratios. 500 1000 1500 XantusTM-2 is run by BaySpec’s Micro 20/20 software that has an -1 intuitive, streamlined user interface and can output data in .txt, .csv, Raman Shift (cm ) or .spc format. Baseline correction function is intelligently built in, which greatly facilities reduction in fluorescence interference and account for drift in background.
2000
XantusTM -2 not only has no moving parts but also has its sensitive optical engine shock-resistant mounted, resulting in a ruggedized instrument that has withstood the rigors of field testing.
12
BaySpec, Inc. | 101 Hammond Ave., Fremont, California 94539 USA | : 1.510.661.2008 |: 1.510.661.2009 | www.bayspec.com
XantusTM-2 Raman Analyzer Bring Instrumentation to the Sample The XantusTM-2 can perform measurements either via direct focusing or through a vial holder. For hard to reach spaces where a fiber collection bundle is more appropriate a fiber optic adapter is available. The XantusTM-2 can handle samples in liquid, gel, powder, or solid forms, under laboratory conditions, or field environments, thus fulfilling the promise of bring instrument to the sample.
1064 nm laser spectrum
Specifications Part Number
HRAM-2-1064
Size Dimensions (mm3)
140 x 218 x 410
Weight
< 7.3kg (15.9 lbs)
Excitation Source Wavelength
1064 nm
Bandwidth
0.2 nm typ./ 0.3 nm max. (FWHM)
Output power
100 - 500 mW
Spectrograph Grating technology
Transmission Volume Phase Grating (VPG®)
Range (785nm)
250-2100 cm-1
Spectral resolution
~12-15 cm-1
Stray light rejection
0.05%
Detector Raman Spectra of Starflower Oil
Type
785 nm 1064 nm
TE cooled InGaAs
Number of pixels
512
Pixel size
25 µm
Cooling temperature
-50 °C
Integration time
0 - 300 sec.
Readout speed
250 kHz
Digitalized output
16-bit
Dynamic range
500:1 typ.
Quantum Efficiency (max.)
>90%
Electronics
500
1000
1500
2000
2500
-1
Raman Shift (cm ) Comparison of Raman spectra of starflower oil taken with 785 nm and 1064 nm lasers, showing reduction in fluorescence.
Interface
USB 2.0
Input power
Battery operated
Trigger mode
5 V TTL edge or level (optional)
Battery life
2 hrs
Software GUI
Micro 20/20 for Windows
SDK
DLL, Sample Codes for VC and LabVIEW
Spectral libraries
User built or 3rd party (optional)
2009 BaySpec, Inc.; VPG is a registered trademark of BaySpec; Nomadic, Portability, RamSpec, and Xantus are commercial trademarks of BaySpec.
13
PortabilityTM-1 Raman Analyzer Research-grade
Transportable
Battery-operated
Ideal for:
Polymorphs classification
Incoming materials inspection
Outgoing materials certification
Geochemical applications
Forensic laboratories
Quality Control/Assurance
Smaller than a typical lunch cooler and battery operated, the Portability TM Raman analyzer can be easily moved from lab to lab or transported to the field, yet under the hood it has a research grade Raman spectral engine. Aided by a 2048 element CCD array detector thermoelectrically cooled to less than –20 °C, the PortabilityTM delivers full spectral coverage (300 to 3200 cm-1) with 5 cm-1 resolution. In addition to on board data processing functions, the Portability TM can transmit data to centralized facilities via WiFi networks, thus enabling real time communication and decision making in mission critical situations.
Tailored for Raman The PortabilityTM-1 is equipped with a 785 nm laser stabilized for Raman spectroscopy. Output power: >500 mW. Linewidth: 0.2 nm FWHM typical.
Cyclohexane @ 1 s integration
At the heart of the PortabilityTM-1 is a transmissive VPG that delivers unsurpassed optical throughput. The spectrograph offers full spectral coverage from 300 to 3200 cm-1 . The detector is a 2048 pixel CCD array thermoelectrically cooled to –20 °C that drastically reduces dark currents and delivers superior signal to noise ratios. The PortabilityTM-1 runs on BaySpec’s Micro 20/20 software that has an intuitive, streamlined user interface and can output data in .txt, .csv, or .spc format. Baseline correction function is intelligently built in, which greatly facilities reduction in fluorescence interference and account for drift in background.
500
1000
1500
2000
2500
3000
-1
Raman Shift (cm )
The PortabilityTM-1 not only has no moving parts but also has its sensitive optical engine shock-resistant mounted, resulting in a ruggedized instrument that has withstood the rigors of field testing.
14
BaySpec, Inc. | 101 Hammond Ave., Fremont, California 94539 USA | : 1.510.661.2008 |: 1.510.661.2009 | www.bayspec.com
PortabilityTM-1 Raman Analyzer Bring Instrumentation to the Sample The PortabilityTM performs measurements via an active probe that can handle samples in liquid, gel, powder, or solid forms, under laboratory conditions, or field environments, thus fulfilling the promise of bring instrument to the sample.
Active Probe
Specifications Part Number
PRAM-1-0785
Size Dimensions (mm3)
240 x 260 x 135
Weight
< 4.5kg (9.9 lbs)
Excitation Source Wavelength
785 nm
Bandwidth
0.2 nm typ./ 0.3 nm max. (FWHM)
Output power
100 - 500 mW
Spectrograph
EQUAL
®
Grating technology
Transmission Volume Phase Grating (VPG®)
Range (785nm)
200-3200 cm-1
Spectral resolution
~5-7 cm-1
Stray light rejection
0.05%
Detector Type
SUGAR
TE cooled CCD
Number of pixels
2048
Pixel size
14 µm
Cooling temperature
-20 °C
Integration time
0 - 300 sec.
Readout speed
250 kHz
Digitalized output
16-bit
Dynamic range
3000:1 typ.
Quantum Efficiency (max.)
>90%
Electronics Interface
Touch panel or USB 2.0 for external PC
Input power
Battery operated
Trigger mode
IN/OUT 5 V TTL edge or level
Battery life
4 hrs
Software 200
400
600
800
1000
1200 -1
Raman Shift (cm )
1400
1600
BaySpec
Micro 20/20 for Windows
SDK
DLL, Sample Codes for VC and LabVIEW
Spectral libraries
User built or 3rd Party (optional)
2009 BaySpec, Inc.; VPG is a registered trademark of BaySpec; Nomadic, Portability, RamSpec, and Xantus are commercial trademarks of BaySpec.
15
RamSpecTM-1 Raman Analyzer High Performance
Transportable
Versatile
Reliable
Ideal for:
Polymorphs classification
Process monitoring
Trace contamination identification
Geochemical applications
Forensic laboratories
Chemical/Biotech research facilities
The RamSpecTM-1 Raman analyzer, being the most compact instrument in its class, can be easily transported from one location to another, yet it is equipped with a high performance Raman spectral engine. Aided by a 2048 element CCD array detector thermoelectrically cooled to less than –20 °C, the RamSpecTM-1 delivers full spectral coverage (300 to 3200 cm-1) with 5 cm-1 resolution. In addition to the standard 785 nm excitation laser wavelength, the RamSpec TM-1 can also be integrated with a 532 nm or 1064 nm excitation source, thus offering unprecedented flexibility and versatility in a laboratory instrument.
Tailored for Raman The standard RamSpecTM-1 is equipped with a 785 nm laser stabilized for Raman spectroscopy. Output power: >500 mW. Linewidth: 0.1 nm FWHM typical. 532 nm and 1064 nm lasers are also available with the RamSpecTM-1 system. At the heart of the RamSpecTM-1 is a custom made transmissive VPG that delivers unsurpassed optical throughput. The spectrograph offers full spectral coverage from 300 to 3200 cm-1 . The detector is a 2048 pixel CCD array for 532/785 nm excitation, which is thermoelectrically cooled to –20 °C that drastically reduces dark currents and delivers superior signal to noise ratios. For 1064 nm excitation the detector is an InGaAs array thermoelectrically cooled to below 50 °C , offering spectral coverage and signal to noise ratios previously only available from FT systems.
Cyclohexane @ 1 s integration
500
1000
1500
2000
2500
3000
-1
Raman Shift (cm )
The RamSpecTM-1 runs on BaySpec’s Spec 20/20 software that has an intuitive, streamlined user interface and can output data in .txt, .csv, or .spc format. Baseline correction function is intelligently built in, which greatly facilities reduction in fluorescence interference and account for drift in background. Additionally, Spec 20/20 offers a suite of other useful features such as peak identification and integration, overlay of spectra, and arithmetic operations. 16
BaySpec, Inc. | 101 Hammond Ave., Fremont, California 94539 USA | : 1.510.661.2008 |: 1.510.661.2009 | www.bayspec.com
RamSpecTM-1 Raman Analyzer Bring Instrumentation to the Sample The RamSpecTM-1 performs measurements via a custom designed optical-fiber based Raman probe that can accommodate samples in liquid, gel, powder, or solid forms. The Raman probe can also be easily integrated into a larger system for automated process or environment monitoring.
Raman Probe
Specifications* Part Number
BRAM-1-0785
Size Dimensions (mm3)
134x315x84
Weight Excitation Source
4 kg (8.8 lbs)
Wavelength
785 nm
Bandwidth
0.2 nm typ./ 0.3 nm max. (FWHM)
Output power
100 - 500 mW
Spectrograph
Raman spectra of white and red wines taken with BaySpec’s 1064 nm RamSpecTM-1 system
Grating technology
Transmission Volume Phase Grating (VPG®)
Range (785nm)
200-3200 cm-1
Spectral resolution
~5 cm-1
Stray light rejection
0.05%
Detector Type
TE cooled CCD
Number of pixels
2048
Pixel size
14 µm
Cooling temperature
-20 °C
Integration time
0 - 300 sec.
Readout speed
250 kHz
Digitalized output
16-bit
Dynamic range
3000:1 typ.
Quantum Efficiency (max.)
>90%
Electronics Interface
USB 2.0 for external PC
Input power
110 to 220 V AC
Trigger mode
IN/OUT 5 V TTL edge or level
Battery life
N/A
Software
Raman spectra of new and used engine oil taken with BaySpec’s 1064 nm RamSpecTM-1 system
BaySpec
Spec 20/20 for Windows
SDK
DLL, Sample Codes for VC and LabVIEW
Spectral libraries
User built or 3rd Party (optional)
* Specifications are given for the 785 nm system. For 532 nm and 1064 nm laser sources please inquire with BaySpec.
2009 BaySpec, Inc.; VPG is a registered trademark of BaySpec; Nomadic, Portability, RamSpec, and Xantus are commercial trademarks of BaySpec.
17
NomadicTM Raman Microscope Versatile
Reliable
Ruggedized
Powerful
Ideal for:
Biomedical research
Forensic labs
Fluorescence suppression
Authentification/Anticounterfeiting
Teaching labs
Central facilities
The NomadicTM is the only Raman microscope on the market today that is simultaneously equipped with three excitation sources (532, 785, and 1064 nm). The dedicated spectrographs and detectors for each excitation wavelength ensures optimal spectral coverage, resolution, and sensitivity, with no trade-offs or compromises. Coupled with micrometer spatial resolution from a research grade optical microscope, the NomadicTM delivers the full power of micro Raman spectrometry with unprecedented flexibility and versatility.
Tailored for Raman Each NomadicTM is equipped with three narrow linewidth lasers stabilized for Raman spectroscopy. The output powers are greater than 500 mW and 250 mW for 785 nm and 1064 nm excitation sources respectively and no less than 50 mW for the 532 nm source. The linewidths are typically less than 0.2 nm FWHM. For each excitation source there is a dedicated spectrograph and detector. All the spectrographs are equipped with a high efficiency transmission VPG that delivers unsurpassed optical throughput. The gratings are customized to either cover the chemically informative 400-1700 cm-1 range or the full 200-3200 cm-1 range. For 532 nm excitation, the detector is a 2024 element CCD array detector, while for 785 nm source the CCD array detector is thermoelectrically cooled to below -20 °C for superior signal to noise ratio in the wavelength range from 900 to 1100 nm. For 1064 nm excitation, the array detector is based on InGaAs and thermoelectrically cooled to below -50 °C to suppress dark currents from thermal noise and maximize signal relative to the noise floor. The NomadicTM is run by BaySpec’s Micro 20/20 software that has an intuitive, streamlined user interface and can output data in .txt, .csv, or .spc format. Baseline correction function is intelligently built in, which greatly facilities reduction in fluorescence interference and account for drift in background.
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BaySpec, Inc. | 101 Hammond Ave., Fremont, California 94539 USA | : 1.510.661.2008 |: 1.510.661.2009 | www.bayspec.com
NomadicTM Raman Microscope Chemical Imaging at Your Finger Tips 4-Acetaminophenol @ 1 s integration
Combining the power of optical microscopy and Raman spectroscopy in true confocal geometry, the NomadicTM provides molecular finger print information on every point of the sample, with sub-micrometer spatial resolution. It can accommodate samples in solid, powder, liquid, or gel forms. Depending on the nature of your sample, you may choose 532 nm excitation for its high sensitivity or 1064 nm excitation to suppress fluorescence o r 78 5 nm to b alance b o th co ncerns. Either way, the NomadicTM delivers the full power of micro Raman spectrometry at your finger tips, in a surprisingly compact and cost-effective package.
500
1000
1500 2000 Raman Shift (cm-1)
2500
3000
Specifications Part Number Size
RMIC-1
Dimensions (mm3)
420 (W) x 410 (D) x 680 (H)
Weight
31.5 kg (70 lbs.)
Excitation Source Wavelength
532 nm
785 nm
1064 nm
linewidth
0.05 nm typ.
0.09 nm typ.
0.12 nm typ.
Output power (max)
50 mW
500 mW
300 mW
Spectrograph Grating technology -1
Transmission Volume Phase Grating (VPG®)
Spectral range (cm )
300—3200
300 - 3200
Spectral resolution (cm-1)
5
5
400 - 1800 5
Spatial resolution* (um)
1 typ.
1.5 typ.
2 typ. TE cooled InGaAs
Detector Type
TE cooled CCD
TE cooled CCD
Number of pixels
2048
2048
512
Pixel size
14 µm
14 µm
25 µm
Cooling temperature
-20 °C
-30 °C
-50 °C
Integration time
0 - 300 sec.
0 - 300 sec.
0 - 300 sec.
Readout speed
250 kHz
Digitalized output
16-bit
Dynamic range
5000:1
3000:1
1000:1
Quantum Efficiency (max.)
>90%
>90%
>85%
Electronics Interface
USB 2.0
Input power
110—220 V AC
Trigger mode
5 V TTL edge or level (optional)
Software GUI
Micro 20/20 for Windows
SDK
DLL, Sample Codes for VC and LabVIEW
Spectral libraries
User built or 3rd party (optional)
*Objective dependent 2009 BaySpec, Inc.; VPG is a registered trademark of BaySpec; Nomadic, Portability, RamSpec, and Xantus are commercial trademarks of BaySpec.
19
Customized Instruments With a dedicated and experienced team of instrumentation engineers and scientists, BaySpec has delivered over 15,000 spectrometers and spectrographs to leading research institutions around the world. Whether you need a unique laser wavelength or power, or a specific wavelength coverage and spectral resolution, or special mechanical dimensions, please contact us for a quote. We have the reputation for providing affordable, high-quality, customized spectroscopic solutions to our customers.
OEM Partnership For the past decade BaySpec has been a leader in lowcost, high-volume manufacturing in the optical telecommunications industry and a reliable OEM partner for some of the Fortune 500 companies in the world. We understand what it takes to initiate and sustain a win-win partnership and thrive in an extremely competitive marketplace. Contact us with your OEM opportunities, whether it is a well established product or a brand new application, we are open-minded and thrive to create a long lasting and mutually beneficial relationship with you.
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BaySpec, Inc. | 101 Hammond Ave., Fremont, California 94539 USA | ď&#x20AC;¨: 1.510.661.2008 |ď&#x20AC;ˇ: 1.510.661.2009 | www.bayspec.com
Accessories for Raman Analyzers 3 1 4 5
2
6
Item #
1
2
3
4
5
6
Name
Description
Integrated Raman probe that provides excitation laser delivery, Raman Active Raman scattering collection, laser line filtering, and electrical trigger in one Probe ergonomically optimized package. Available for both 785 nm and 1064 nm excitation laser wavelengths. Integrated Raman probe that provide excitation laser delivery, Raman Optical Raman scattering collection, and laser line filtering in one compact package. Probe Available for both 785 nm and 1064 nm excitation laser wavelengths.
Sample Vial Holder
Precision machined part that holds 10 mm diameter glass vials and fits all BaySpec Raman probes. Open slots also accommodate solid tablet samples mounted on business cards.
Solid Sampling Precision machined cone that fits on all BaySpec Raman probes and Cone minimizes random scattering from solid samples. Laser Shield Ruggedized Carrying Case
Part Number:
PROB-Aâ&#x20AC;&#x201D;785 PROB-A-1064
PROB-S-0785 PROB-S-1064
RAHV
RASC
Optical laser shield that provides at least 10-6 blocking efficiency at laser excitation wavelength and fits all BaySpec Raman probes.
RALS-0785
Case with pick and pluck foam. Air and water tight. Lifetime warranty.
RACC
RALS-1064
ď&#x192;Ł2009 BaySpec, Inc.; VPG is a registered trademark of BaySpec; Nomadic, Portability, RamSpec, and Xantus are commercial trademarks of BaySpec.
21
Software: Micro 20/20 Intuitive Graphical User Interface (GUI): Important setup parameters, spectrum display, and real-time status indicators are all on a single, easy-to-see screen. Especailly designed for touch screen operations.
Pane 1 Pane 3
Micro 20/20 GUI Pane 1: Spectrum window Pane 2: Data viewer Pane 3: Control panel
Pane 2
Flexible, Multiple Data Formats: Can save and open data files in ASCII (.txt), Excel (.csv), or Grams/AI (.spc) to allow user the maximum flexibility in data storage and retrieval and interfacing to third party software packages.
Automated Calibration Procedure: Built-in, automated calibration procedure leads users through easy-to-follow steps to accomplish Raman shift calibration in less than 30 seconds.
22
BaySpec, Inc. | 101 Hammond Ave., Fremont, California 94539 USA | ď&#x20AC;¨: 1.510.661.2008 |ď&#x20AC;ˇ: 1.510.661.2009 | www.bayspec.com
Software: Micro 20/20 Intelligent Baseline Correction Function:
Aspirin Raman Spectra with and without Baseline Correction
Baseline constructed from multi-segment, smoothed polynomial allows effective removal of fluorescence background and slanted baseline with minimal artificial bias.
Raw trace Baseline corrected
Tailored Substance Libraries: With Micro 20/20 the user can quickly and easily build his/her own compound libraries to meet his/her specific identification needs, or can import libraries from third party vendors. 400
600
800
1000
1200
1400
1600
1800
2000
-1
Raman Shift (cm )
Powerful Substance Identification Functions: Whether the library is user built or imported from third parties, Micro 20/20 can identify unknown substances instantaneously and report quantitatively the match quality. It can even be trained to recognize mixtures.
ď&#x192;Ł2009 BaySpec, Inc.; VPG is a registered trademark of BaySpec; Nomadic, Portability, RamSpec, and Xantus are commercial trademarks of BaySpec.
23
Applications of Raman Spectroscopy Raman spectroscopy is a non-destructive, no contact analytical technique that requires no or little sample preparation. With falling price barriers and reduction in physical dimensions its application areas are rapidly expanding, from lipid content determination in algae to crystal form identification in zeolites. Some of the most common application fields are high-lighted below.
Chemical
Biological
Incoming/outgoing materials inspection and certification
In situ, non-contact measurement of tissue samples, non-destructive, no labeling needed
Online/at-line detector for Process Analytical Technology (PAT)
Intracellular chemical mapping
Lipid content quantitation in algae for biofuels
Polymers: correlation of physical/chemical properties (molecular weight, viscosity, glass transition temperature, etc.) with Raman spectra
Bacteria detection
SERS for low level biological threat detection
Petroleum product identification and analysis
Identification of resins, petrochemicals, and commodity chemicals
Forensics
Non-destructive and safe drug and narcotic identification / preservation of evidence
Identification of explosives
Trace forensic analysis of fibers, hair, pigments, ink, fabrics, etc.
Toxic solvents identification
Pharmaceutical
Drug polymorphs/solvates identification and classification
Identification of drug co-crystals
Content analysis of tablets, gel caps, and liquids
QA/QC of API, additives, and excipients
Fast analytical tool for High Throughput Screening
Educational
24
Undergraduate/professional teaching labs
Geological
Field expeditions
Non-destructive identification of geological materials
Live demonstration in lecture halls
Authentification and anti-counterfeiting of gemstones
Replacement for outdated bench-top instruments
Origin identification of minerals and gemstones
Evaluation of mining prospects
BaySpec, Inc. | 101 Hammond Ave., Fremont, California 94539 USA | : 1.510.661.2008 |: 1.510.661.2009 | www.bayspec.com
Applications of Raman Spectroscopy
Challenges from the Real World Methanol content in gasoline quantified by XantusTM-0 Panel below shows pure methanol, 50-50 methanol -gasoline, and pure gasoline, respectively. Panel on the right shows the standard calibration curve
Gasoline
50-50
Correlation of spectral quantity with CH 3OH percentage in gasoline
Methanol
Spectral quantity (a.u.)
2.5 y = 1.6421x + 0.6023 R² = 0.996
2
1.5 1
0.5 0
600
800
1000
1200
1400
1600
1800
-1
Raman Shift (cm )
0%
20%
40%
60%
80%
Methanol (percentage)
100%
Raman Signal vs. Phosphate Concentration
Ammonium dibasic phosphate granules
Phosphate content in fertilizers determined by XantusTM -1 0
50
100
150
Phosphate mg/ml
200
250
Panel on the left shows the standard calibration curve
Solutions for the Real World ď&#x192;Ł2009 BaySpec, Inc.; VPG is a registered trademark of BaySpec; Nomadic, Portability, RamSpec, and Xantus are commercial trademarks of BaySpec.
25
Raman Analyzer Selection Guide
Model
Xantus-0A
Xantus-0B
Xantus-1
Xantus-1G
Xantus-2
Part Number
HRAM-0A-0785
HRAM-0B-0785
HRAM-1-0785
HRAM-1G-0785
HRAM-2-1064
Size Dimensions (mm3)
85 x 190 x 50
95 x 195 x 60
125 x 223 x 85
140 x 218 x 410
Weight
1 kg (2.2 lbs.)
1.5 kg (3 lbs.)
2.4 kg (4.7lbs.)
< 7.3kg (15.9 lbs)
Optional
N/A
Excitation Source 532 nm
Optional
785 nm
n
n
N/A
1064 nm
N/A
N/A
n
Laser linewidth
0.2 nm typ./ 0.3 nm max. (FWHM)
0.2 nm typ./ 0.3 nm max. (FWHM)
0.2 nm typ./ 0.3 nm max. (FWHM)
Output power
~80 mW
100 - 500 mW
100 - 500 mW
Spectrograph Grating technology
VPG®
VPG®
VPG®
Range (785nm)
500-1800 cm-1
500-1800 cm-1
250-2100 cm-1
Spectral resolution
~15-17 cm-1
~10-12 cm-1
~12-15 cm-1
Stray light rejection
0.05%
0.05%
0.05%
Detector Type
CCD
TE cooled CCD
TE cooled InGaAs
Number of pixels
1024
1024
512
Pixel size
14 µm
14 µm
25 µm
Cooling temperature
Ambient
-20°C
-50 °C
Integration time
0 - 300 sec.
0 - 300 sec.
0 - 300 sec.
Readout speed
250 kHz
250 kHz
250 kHz
Digitalized output
16-bit
16-bit
16-bit
Dynamic range
2000:1 typ.
3000:1 typ.
1000:1 typ.
Quant. Eff. (max.)
>90%
>90%
>85%
Interface
USB 2.0
USB 2.0
USB 2.0
Input power
Battery operated
Battery operated
Battery operated
Trigger mode
5 V TTL edge or level (optional)
5 V TTL edge or level (optional)
5 V TTL edge or level (optional)
Battery life
4 hrs
4 hrs
2 hrs
GUI
Micro 20/20 for Windows CE
Micro 20/20 for Windows
Micro 20/20 for Windows
SDK
DLL, Sample Codes for VC and LabVIEW
DLL, Sample Codes for VC and LabVIEW
DLL, Sample Codes for VC and LabVIEW
3rd party libraries
N/A
Optional
Optional
Electronics
Software
26
BaySpec, Inc. | 101 Hammond Ave., Fremont, California 94539 USA | : 1.510.661.2008 |: 1.510.661.2009 | www.bayspec.com
Raman Analyzer Selection Guide
Model
Portability-1
RamSpec-1*
Nomadic
Part Number
PRAM-1-0785
BRAM-1-0785
RMIC-1
Dimensions (mm3)
240 x 260 x 135
134x315x84
420 (W) x 410 (D) x 680 (H)
Weight
< 4.5kg (9.9 lbs)
4 kg (8.8 lbs)
31.5 kg (70 lbs.)
532 nm
Optional
Optional
785 nm
n
n
1064 nm
N/A
Size
Excitation Source
532 nm
785 nm
1064 nm
Spatial resolution (um)# 1 typ.
1.5 typ.
Optional
2 typ.
#Objective dependent
Laser linewidth (FWHM)
0.2 nm typ./ 0.3 nm max.
0.1 nm typ./ 0.2 nm max.
0.05 nm typ.
0.09 nm typ.
0.12 nm typ.
Output power
100 - 500 mW
100 - 500 mW
50 mW max.
500 mW max.
300 mW max.
VPG®
VPG®
Spectrograph Grating technology Range (785nm)
200-3200 cm
-1
200-3200 cm
VPG® -1
-1
300—3200 cm 5 cm
-1
-1
300 - 3200 cm-1 5 cm
400 - 1800 cm-1
-1
5 cm-1
Spectral resolution
~5-7 cm-1
~5 cm
Stray light rejection
0.05%
0.05%
0.05%
0.05%
0.05%
Detector Type
TE cooled CCD
TE cooled CCD
TE cooled CCD
TE cooled CCD
TE cooled InGaAs
Number of pixels
2048
2048
2048
2048
512
Pixel size
14 µm
14 µm
14 µm
14 µm
25 µm
Cooling temperature
-20 °C
-20 °C
-20 °C
-25 °C
-50 °C
Integration time
0 - 300 sec.
0 - 300 sec.
0 - 300 sec.
0 - 300 sec.
0 - 300 sec.
Readout speed
250 kHz
250 kHz
250 kHz
250 kHz
250 kHz
Digitalized output
16-bit
16-bit
16-bit
16-bit
16-bit
Dynamic range
3000:1 typ.
3000:1 typ.
5000:1
3000:1
1000:1
Quant. Eff. (max.)
>90%
>90%
>90%
>90%
>85%
Touch panel or USB 2.0 external PC
USB 2.0 for external PC
Electronics Interface
USB 2.0 for external PC
Input power
Battery operated
110 to 220 V AC
110—220 V AC
Trigger mode
IN/OUT 5 V TTL edge or level
IN/OUT 5 V TTL edge or level
5 V TTL edge or level (optional)
Battery life
4 hrs
N/A
N/A
Micro 20/20 for Windows
Spec 20/20 for Windows
Micro 20/20 for Windows
Software GUI SDK 3rd party libraries
DLL, Sample Codes for VC and LabVIEW Optional
DLL, Sample Codes for VC and LabVIEW
Optional
Optional
* Specifications are given for the 785 nm system. For 532 nm and 1064 nm laser sources please inquire with BaySpec.
2009 BaySpec, Inc.; VPG is a registered trademark of BaySpec; Nomadic, Portability, RamSpec, and Xantus are commercial trademarks of BaySpec.
27
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