Lori Viar, Medical Communications and Marketing

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LORI L. VIAR STRATEGIC COMMUNICATIONSMARKETINGMEDICALAND Speaker Programs KOL Physician Relations Ad Board Planning and Content Marketing Tools based on Clinical Data Social Media Content and Physician Reviews Industry Trade Publications Trade Show and Podium Presence Abstracts and Poster Presentations Industry Public Relations National Sales Meetings

PHYSICIAN PR AND SOCIAL MEDIA

Identify KOL Physician for product reviews. Provide compliant talking points to Physician and approve final copy Repurpose consumer-facing mentions as Instagram and other social media posts

Dr. Cohen: Skincare is a very impor tant complement to the procedures that recommend and perform every day. want products that work, are supported by clinical data that patients also enjoy using.

WHAT TYPES OF RESULTS ARE PATIENTS SEEING WITH REGULAR USE? Dr. Downie: In a pivotal trial, the investigator noticed significant improvements in the appearance of discolor ation in 85 percent of subjects. In the same trial, 92 percent of users saw improvements in the appearance of brown patches. n

Modern Aesthetics “New In My Practice”

s NEW IN MY PRACTICE COSMECEUTICALS

How do you suggest your patients use Dermal Repair UltraNourish?

WHAT IS CYSPERA? Jeanine B. Downie, MD: Cyspera is the first topical cream containing cysteamine hydrochloride (HCI) to diminish the appearance of stubborn skin discoloration. Cyspera is for mulated without hydroquinone or retinol, which makes it well tolerated for long-term use. Cysteamine delivers anti oxidant activity with multiple effects on the appearance of skin discoloration.

SENTE’S CYSPERA

„ NEW IN MY PRACTICE

Diane Orlinsky, MD: This unique, long-awaited body cream is a deeply nourishing, repairing formula that provides all the benefits of Senté’s pat ented Heparan Sulfate Analog (HSA), Dermatan Sulfate Analog (DSA), and Chondroitin Sulfate Analog (CSA) in one rich product for the body. It deliv ers lasting moisture and helps the skin repair from within by boosting the skin’s immune response to inflamma tion. The result is visibly smoother, firmer skin on the body. Which patients is this product ideal for? Eva Simmons-O’Brien, MD: This product is ideal for anyone with dry, crepey, or dull skin on the body who wants to see a noticeable improve ment in skin tone, hydration, and skin quality. Senté Dermal Repair Body Cream is made for daily use to help improve crepey skin by supporting hydration and elasticity and can be used by itself.

What procedures does this product complement?

WITH DIANE ORLINSKY, MD AND EVA SIMMONS O’BRIEN, MD In each issue, Modern Aesthetics® magazine spotlights a new cosmeceutical that aesthetic experts are recommending to patients. Here, dermatologists Diane Orlinsky, MD and Eva Simmons-O’Brien, MD, Co-founders of Simmons-O’Brien & Orlinsky Dermatology in Bellona, MD, share their enthusiasm for Senté Dermal Repair Body Cream UPDATE 48 PRACTICAL DERMATOLOGY MAY 2021

>> THERAPEUTICS

Joel Cohen, MD: As a member of Senté’s Scientific Advisory Board, have discussed that Dermal Repair Cream is one of the best products that carry in my office. It truly helps patients achieve many aspects of healthier skin and is a great complement to many of the procedures that we do, including lasers, fractional radiofrequency microneedling, and peels. My practice participated in the post-procedure case study with positive results, great patient feedback, and no adverse events. It helps restore skin health, enhances moisture and hydration of deeper structures, and improves pigment and redness. Still, in the dry mountain climate when patients are using retinoids, they need more moisturizing qualities.

WHO BENEFITS FROM CYSPERA?

HOW DO YOU SUGGEST YOUR PATIENTS USE CYSPERA?

How does Dermal Repair Ultra-Nourish compare with other products in this category?

Dr. Downie: All ethnicities benefit from Cyspera. recom mend this product to my white, black, Latino, and Asian patients. Everyone seems to benefit from it and likes it a lot. However, since hyperpigmentation is a real bother for more melanin-rich skin, some of my darker skin patients rely on it more.

How do you suggest that your patients use this product? Dr. Orlinsky: We recommend that this product be applied twice a day to areas that they would like to see improvements.

What is Senté Dermal Repair Body Cream?

New in My Practice: Cosmeceuticals

| COSMECEUTICALS

SENTÉ

REPAIRDERMALBODYCREAM

22 MODERN AESTHETICS® MARCH/APRIL 2019

Dermal Repair Body Cream May/June 2022 Dermal Repair Ultra - Nourish May 2021 March/AprilCyspera2020

16 MAY/JUNE 2022

Dr. Cohen: The reality is that there are many patients that simply love Dermal Repair Cream but don’t find it to be moisturizing enough in the winter or when getting started with retinoids. The key in Senté’s products is their HSA technology, which is proven to increase deep and superficial hydration and help minimize inflammation that can appear as visible redness. Very few products provide both immedi ate and long-lasting hydration and moisturization, while even fewer can reduce visible redness to the same degree as Senté’sDermalHSA.Repair Ultra-Nourish meets the needs of so many skin concerns. Also being non-comedogenic and superhydrating, it has fast become a fantastic peri-procedure regi men for my patients. They are using Dermal Repair UltraNourish right up to their laser and peel appointments, then have them restart it a few days after ablative procedures, and right away for non-ablative procedures. What types of results are your patients seeing?

What type of results are your patients seeing with regular use? Dr. Orlinsky: In our clinical case study, 100 percent of subjects showed improvement in dryness, and 67 percent of subjects showed improve ment in tactile roughness by week 8.

Dr. Cohen: Dermal Repair UltraNourish is lightweight enough to use daily and is ideal for sensitive skin and to help patients tolerate nightly reti noid use. As an aesthetic dermatolo gist who does procedures all day on patients with wrinkles, pigment and redness, it’s great to have a product that works on all of these issues. We know from clinical studies that HSA, the key ingredient in Senté Dermal Repair Cream and Dermal Repair UltraNourish, can help to improve facial lines as well as areas of pigment and erythema, which makes it a fantastic comple ment to the procedures that I do all day, including lasers and injectables.

With Joel Cohen MD In each issue, Practical Dermatology® magazine spotlights a new product that dermatolo gists are recommending to patients. Here, Joel L. Cohen, MD, Director of AboutSkin Dermatology and DermSurgery in Greenwood Village and Lone Tree, CO, tells us why he is so excited about Senté’s Dermal Repair UltraNourish Crème and the role he played in its development. What is Senté’s Dermal Repair Ultra-Nourish?

n

Dr. Simmons-O’Brien: We know in general that quality skincare prod ucts complement procedures by supporting and repairing skin health both before and after procedures. This product is meant to be used on intact skin and pairs nicely with any procedure designed to firm the body or improve skin tone on the body. At our practice (find us on Instagram @Ladydermdocs), the Dermal Repair Body Cream is ideal for our post-care regimen after a variety of procedures such as chemical peels, radiofrequen cy, Qwo cellulite injections, Accufit, Kybella, Derma V Intellitone, and 24-48 hours after Genius radiofre quency microneedling. How does skincare fit in with your practice philosophy?

One of my favorite ways to use it is with the Obagi Vitamin C/hydroquinone serum (Obagi-C Rx System) over night on dark patches after using the Cyspera earlier in the evening and then rinsing it off.

Dr. Downie: am recommending it be used on the face every other night for 15 minutes when patients start the product, because sometimes it is too strong to use every night. After about a month or two, allow them to use it for 15 minutes or more on the face. On the body, they can start using it for 30 minutes every night. I do combine it with some of the hydroquinones.

Dr. Orlinsky: Skincare is critical, mandatory, and non-negotiable with our practice philosophy! It is our first priority to ensure that patients achieve optimal skin health with and without procedures. Supple, smooth, radiant skin forgives almost any skin flaw, and is the starting point for all of our cosmetic consults.

I have recommended adding more moisture to Dermal Repair Cream to the Senté corporate team based on my wife’s recommendation and my personal experience as well as so many of my patients’ experience, and they developed Dermal Repair Ultra-Nourish, which has far surpassed my expectations. This is an incredibly moisturizing formulation that still delivers all of the key ingredients of Dermal Repair Cream and its proprietary Heparan Sulfate Analog (HSA) that penetrates into the dermis and helps with key cascades for improving hydration, neocollagenesis, as well as pigment and redness improvement.

Dr. Cohen: We were part of the initial testing over a year ago and since then, I have family and staff members who have indicated that this product does so many things for them. It helps reduce redness, it helps them tolerate retinoids, it layers under sun screen very well. It also helps recover from chemical peels, RF microneedling, as well as various laser procedures from Halo Hybrid Fractional to even full-field ablative erbium. How important is skincare in your overall treatment philosophy?

WITH JEANINE B. DOWNIE, MD In each issue, Modern Aesthetics® magazine asks top cosmetic dermatologists about the newest cosmeceuticals that they are offering to patients. Here, Jeanine B. Downie, MD, FAAD director of image Dermatology PC in Montclair, NJ, talks about Sente’s Cyspera a novel pigment corrector formulated with Cysteamine.

“OURRECOMMEND”PHYSICIANS Instagram Content Sourced quotes from all BriefedEditedPhysicianscopyforcompliancedigitalagency for design *Outperformed all previous content on Senté IG account

INSTAGRAM LIVE Host Weekly Instagram LIVE with Physician CreateCustomersoutline and talking points Recruit and schedule Physicians

Video Shoot at Senté R&D Lab Brianna Stanko, Senté Customer and Influencer Created Reviewedscriptproduct technology and discussion points with Brianna prior to Bookedshoot video crew Provided shot sheet for final video edit

TRADE SHOW PRESENCE § Create Strategic Trade Show Schedule and Budget § Determine Messaging for each meeting based on new Clinical data or new product launch § Identify opportunities for on-podium presence, contact Physicians and provide podium slides § Create all podium slides from clinical data in cooperation with Senté consultant MD and PhD § Work with Physicians presenting posters and abstracts regarding timing, logistics and content § Plan brand event, identify Physician speaker, create presentation for event § Work with SVP, Sales to identify target attendee list § Identify venue for event and execute contracts § Book trade show booth space and logistics vendor

Vivian Bucay,

MD NovemberASDS 2019

Seemal Desai, MD NovemberASDS 2019

SPEAKER

EVENTS Create presentations for Physician speakers Work with Physician speaker to review presentation, company messaging and claims Assist with selection of venue and event logistics

B. Downie, MD Beauty Editor Event New NovemberYork 2019

Jeanine

Aerolase and Jack Zamora, MD November 2019

Skin of Color Society Media Day New FebruaryYork2020

CLINICAL

POSTERS Determine appropriate meeting for content to be submitted Work with consultant MD and PhD to identify Physician Authors for abstracts and posters Communicate with all to ensure submission deadlines are met Coordinate timing of presentation with Physician Author and attend presentation

The Aesthetic Meeting 2021

https://socs2022-trexperts.ipostersessions.com/default.aspx?s=A9-54-3A-ED-E3-70-DB-E3-8B-D3-FA-ED-80-65-36-76&guestview=true

Improvements in Facial Redness and Inflammation: An Open label, single center clinical study including low molecular weight heparan sulfate (HSA) in patients with sensitive skin Joel L. Cohen, MD, FAAD, FACMS1,2, Valerie D. Callender, MD, FAAD3,4, Angel S. Byrd, MD, PhD4 1AboutSkin Dermatology and DermSurgery, PC, Greenwood Village, CO 2Dermatology, University of California, Irvine, CA 3Callender Dermatology & Cosmetic Center, Glenn Dale, MD 4Department of Dermatology, Howard University College of Medicine, Washington, DC American Academy of Dermatology Annual Meeting Boston, MA March 25, 2022 Disclosures: JLC Senté, Inc., Allergan, Galderma, Revance, Sciton, Pulse, Biopelle, Merz, CROMA, InMode, Accure; VDC Eli Lilly and Company, Othro Dermatologics, SkinBetter Science, The Acne Store, UpToDate, SkinCeuticals, LLC, L'Oreal USA, Inc., Allergan, Inc., Aerolase, Allergan, Inc., Senté, Inc. ; ASB is a consultant for Senté, Inc. Funding: Studies conducted by Stephens & Associates, Inc. Support provided by Senté, Inc. American Academy of Dermatology Annual Meeting 2022

Skin of Color Update September 2022

American Academy of Dermatology Annual Meeting 2022

SCALE 2022

National Sales Meetings Las Vegas, January 2018 New Orleans, February 2019 Carlsbad, CA, August 2019 Created meeting content and agenda with SVP, Sales Created and presented Education content for new product launches Worked with SVP, Sales to select venues and meeting dates Planned and booked all entertainment, activities and Awards Dinner

Las Vegas, January 2018

New FebruaryOrleans2019

Carlsbad, CA Cyspera Launch Meeting August

Richard2019Gallo,

MD, PhD

Providers from top producing accounts are invited to our office and lab in Carlsbad, CA to meet with Leadership, learn more about our technology, visit the lab and ”make their own product” with VP of Research & Development. Created program, agenda and content

Developed content for the meeting, identified and prepped all internal team members to deliver Facilitated roundtable discussion regarding new products to be launched

Contracted with hotel and restaurants for attendees

Worked with VP, Sales to identify providers to be invited

Launched Senté Ambassador Program

Senté Ambassador Event, Carlsbad, CA October 2018

PRIVATE AMBASSADOR EVENT BUCKY PLASTIC SURGERY PROVIDERS JANUARY 2020

selling

PRINT MARKETING ASSETS with Physicians to source quotes and points for process with approval for all facing tools, along with selection of clinical claims and selection of photos for

sales Managetoolscreative

final

Physician/Account

Work

B&A

copywriting,

campaign

Senté HSA Marketing Tools

Visit Sentelabs.com to learn more With Cysteamine HSA Pigment & Tone Corrector, more even skin is possible —for everyone

Unwanted hyperpigmentation, be it dark spots or blotchy discoloration, is an equal-opportunity concern: Anyone can experience it, whatever their skin type or tone. As common as it is, however, the exising solutions have fallen short in terms of long-term safety and sun sensitivity—until now.

Meet Cyseamine HSA Pigment & Tone Corrector. This revolutionary treatment brings together two powerful, proven technologies - Heparan Sulfate Analog and Cyseamine HCl, to resore a visibly even complexion to all skin tones without risk of excessive lightening. Better yet, the hydroquinone-free formula is safe for long-term use and gentle enough for even dry, sensitive skin. Senté is known for its patented version of heparan sulfate, HSA, a ground-breaking molecule fundamental to healthy skin, optimized for use in topical skincare products. Our science-backed, dermatologisapproved formulas address dark spots, redness and more without irritation. It’s more even skin, made for everyone.

•BenefitsSolutionHyperpigmentationTheofCysteamineHSA: ••WellHydroquinone-freetoleratedSafeforlong-term use in all skin tones Cysteamine HCI and the power of Heparan Sulfate Analog create the ideal synergy to target pigmentation at multiple points of formation 71% reduction in dark spots at 16 weeks1 1.Randomized,double-blindclinicaltrial.35subjects,ages25-65,

moderate to severe hyperpigmentation. Senté Cysteamine HSA vs. cysteamine only. Data on file, Senté.

DRAMATIC VISIBLE IMPROVEMENTS Baseline BaselineWeek 16 Week 16 RESULTSTHEAREIN FEWER DARK SPOTS 71% reduction in dark spots at16 weeks1 IMPROVED HYPERPIGMENTATION 94% of subjects showed an improvement in hyperpigmentation at 16 weeks1 94% SAW RESULTS 94% of subjects agreed that their stubborn dark patches looked less noticeable at 16 weeks1 2 Page Editorial and Facing Full Page Ad Modern Aesthetics Innovations July/August 2022

More even skin, without the compromise

Patented Heparan Sulfate Analog supports the skin’s immune response to infammation that can lead to hyperpigmentation. Cyseamine is a powerful antioxidant which reduces the oxidative sress that contributes to hyperpigmentation and works at multiple points on the hyperpigmentation pathway.

Introducing Cysteamine HSA Pigment & Tone Corrector In a clinical trial 94% of subjects showed an improvement in hyperpigmentation at 16 weeks1 94% of subjects agreed that their stubborn dark patches looked less noticeable at 16 weeks1 Subject Fitzpatrick53-year-old029Femaleskin-type: III 61%WeekBaselineMASIResults:SCORE:(5.9)16(2.3)improvement 1. Randomized, double-blind clinical trial. 35 subjects, ages 25-65, moderate to severe hyperpigmentation. Senté Cysteamine HSA vs. cysteamine only. Data on file, Senté. STANDARD VIEW BaselineWeek16 How To Use If you have never used this product before, or have sensitive skin, begin with every other day application, advancing to every day use as tolerated. Mild warming sensation, redness or dryness may occur initially. If irritation persists, discontinue use and consult your physician. Once the desired (or maximum) pigment-reducing results are achieved (over the initial period of use), you may adjust to twice a week application to maintain results Recommended Senté Regimen am/pmamor pm am/pm 4. Even Tone Mineral Sunscreen am Step 01 Apply to clean dry skin. If cleansing before use, wait at least 20 minutes until skin is completely dry. Step 02 Apply a thin layer of product daily, either morning or night. Leave on for 15 minutes. Step 03 Wash product off with mild cleanser. Step 04 Apply Senté Dermal Repiar Cream 1520 Detail CysteamineAid HSA Pigment & Tone Corrector

Cysteamine HSA Pigment & Tone Corrector Benefits of Cysteamine HSA: • ••WellHydroquinone-freetoleratedSafeforlong-term use in all skin tones 1. Randomized, double-blind clinical trial. 35 subjects, ages 25-65, moderate to severe hyperpigmentation. Senté Cysteamine HSA vs. cysteamine only. Data on file, Senté. Learn more at sentelabs.com The SolutionHyperpigmentation Two powerful, proven technologies Heparan Sulfate Analog and Cysteamine HCl restore a visibly even complexion to all skin tones.reduction in dark spots at 16 weeks1 71% STANDARD VIEW Baseline Week 16 Full Page Ad Aesthetic Society News New Beauty Magazine MediaSocialPhysician

1. Randomized, double-blind clinical trial. 35 subjects, ages 25-65, moderate to severe hyperpigmentation. Senté Cysteamine HSA vs. cysteamine only. Data on file, Senté.

Pigment & Tone Corrector

improve the appearance of

Patient Rack Card Point of Sale Counter Card Pop-Up Event Banner

Subject 012: 60-year-old Female; Fitzpatrick skin-type: V Results: MASI SCORE — Baseline (16.2) Week 16 (4.8). 70.37% improvement.

Meet Cysteamine HSA

Two powerful, proven technologiesHeparan Sulfate Analog (HSA) and Cysteamine HCl restore a visibly even complexion to all skin tones without risk of excessive lightening. 71% overall reduction in brown spots1

Baseline Week 16 Baseline Week 16

Hydroquinonefree Parabenfree FragrancefreeDermatologist-tested

Cysteamine HSA Pigment & Tone Phospholipids pairing, which work from within to target the key causes of hyperpigmentation and help visibly dark spots in all skin tones.

Corrector The Hyperpigmentation Solution BENEFITS Effectively, gently improves the appearance of dark spots Restores natural skin tone without risk of hypopigmentation Well Safetoleratedforlong-term use HCICysteamine Niacinamide AscorbateTHD

The Pigmentation Solution

Our breakthrough formulation features two exclusive ingredient

Subject 029: 53-year-old Female; Fitzpatrick skin-type: III Results: MASI SCORE — Baseline (16.2) Week 16 (4.8). 70.37% improvement.

CONTACT LORI.VIAR@GMAIL.CO M

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