BT 1358 | 2013
PROTEIN ENGINEERING MARKET [Products (Monoclonal Antibody, Insulin Analog, Modified EPO), Technology (Sequential Modification, Glycosylation, PEGylation), and Applications (Therapeutics, Diagnostics, Research)] -
Global Forecast To 2017 Report Description Ta b l e o f C o n t e n t s L i s t o f Ta b l e s About Markets and Markets Related Reports
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BT 1358 | 2013
Protein Engineering Market - Global Forecast To 2017
Report Description Key Take-Aways •
Analysis of current and emerging technologies in the global protein engineering market
•
Definition, measurement, and forecast of the global protein engineering market
•
Analysis of the global protein engineering market by geography, technology, products, and applications
•
Region-wise analysis of the market based on products
•
Growth impact analysis with drivers and restraints, and their impact for a five-year timeline
Assumption Particulars
Protein Engineering Market
Description • The market for protein engineering is calculated based on sale of products, which are derived using hybrid protein technologies ( eg. fusion proteins (Rilonacept)), PEGylated proteins, second generation proteins derived through engineering of first generation proteins (for eg. insulin analogs, Monoclonal antibodies and second generation Erythropoietin). This report does not include first generation recombinant proteins that were merely derived using recombinant technology for market size estimation and forecast. • Diagnostics market segment is derived majorly based on the use of monoclonal antibodies for diagnostic applications. • Market for engineered proteins for research applications is assumed to account only 0.25% of the total market.
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BT 1358 | 2013
Protein Engineering Market - Global Forecast To 2017
Report Description Research Methodology
Regional Market share
Description • Regional market share is derived based on the present market scenario and sale of products in the region. Despite stringent FDA regulations North America is assumed to grow at a faster rate compared to Europe which has been known for faster product approvals compared to any other market. Asia is assumed to grow at a higher rate because of changing economic conditions and growing demand for bio-therapeutics. • Population of diabetes and cancer incidence rates are derived based on incidence per 100,000.
General Assumption
• It is assumed that the market is expected to have a normal growth as there are no significant changes expected in the market scenario and regulatory landscape during the forecasted period.
Report Description This technology report gives a brief description of protein engineering technologies, recent trends, and future development. It also covers protein product systems, their advantages and upcoming trends. Technologies that are analyzed in the report include Sequence Modification/Glycosylation, PEGylation, display technologies, humanization technologies, hybrid technologies, and transgenic mice. The market has been categorized by geography, application, products and technology. Forecast has been made by analyzing current and future trends in therapeutic and diagnostics applications. The protein engineering market is segmented on the basis of its application into
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therapeutics, diagnostics, and research application. Product segments are classified as monoclonal antibodies, Insulin analogs, EPO, other proteins, diagnostics, and research applications. Further geographic segmentation is done based on products and markets for monoclonal antibodies (therapeutic condition). An impact analysis of major drivers and restraints influencing the adoption and growth of the market during from 2012 to 2017 has also been obtained. Major countries’ market potential and current development in the region is discussed to give a brief idea on potential adoption and growth of the industry. Competitive landscape, strategies adopted, and proprietary platform technologies of companies are discussed briefly.
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BT 1358 | 2013
Protein Engineering Market - Global Forecast To 2017
Report Description Research Methodology RESEARCH PROCESS
Secondary Research
Primary Research Universities, Doctors, CRO’s, CMO’s & Companies
Technology Journals
Market Research Reports
Discussion Guide/ Questionnaire Preparation
Secondary Sources
Data Points, Trends & Strategy
Technology Information websites
E-mail & Telephonic Interviews §Generating Insights
Internal Databases
§Key Findings
Primary Primary Sources Sources
M&M M&M Consultants
Consultants
Online Surveys
§Market Forecasts Thought Leader Briefings
DATA TRIANGULATION
Data Validation
PDF Format (End Deliverable)
Note: *Target Sample - Research Scientists/Professors, CEOs/CSOs, Research and Product Development officers, Strategic Decision Makers, Technology Policy Heads
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BT 1358 | 2013
Protein Engineering Market - Global Forecast To 2017
Report Description Key Data Points from Primary and Secondary Sources Data Points from Secondary Sources •
Protein engineering technologies
•
Product and revenue details of companies
•
Mergers, acquisitions, new product developments and investment deals
•
Market revenue trends and market dynamics
Data Points from Primary Sources •
Market shares of different technologies
•
Recommendation of strategies
•
Region-wise growth rate and market shares
•
Verification of secondary data
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BT 1358 | 2013
Protein Engineering Market - Global Forecast To 2017
Table of Contents 1. Introduction
.....................................................................................................................................................................18-23
1.1
Key Take- Aways
1.2
Report Scope
1.3
Report Segmentation
1.4
Research Methodology
1.5
Key Data Points from Primary and Secondary Sources
2. Executive Summary................................................................................................................................................................24-27
3. Protein Engineering Technologies – Landscape Analysis.................................................................................................28-45 3.1
Technology - Introduction
3.2
Technology – Evolution
3.3
Market Segmentation
3.4
Protein and Antibody Engineering Technologies – Overview
3.4.1
Sequence Modification
3.4.2
Glycosylation
3.4.3
Pegylation
3.4.4
Display Technologies
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BT 1358 | 2013
Protein Engineering Market - Global Forecast To 2017
Table of Contents 3.4.5
Humanization technology
3.4.6
Hybrid technology
3.4.7
Production systems
3.4.8
Mapping of protein production systems
3.4.9
Emerging production systems
3.5
Protein Engineering – Technology Value Chain Analysis
4. Applications 4.1
....................................................................................................................................................................46 - 54
Therapeutic Development – Overview
4.1.1
Insulin analogs
4.1.2
Monoclonal antibodies
4.1.3
Therapeutic development - erythropoietin & others
4.2
Diagnostics
4.3
Research – Meganuclease Engineering/ZFP & TALENS Engineering
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BT 1358 | 2013
Protein Engineering Market - Global Forecast To 2017
Table of Contents 5. Market Landscape Analysis.................................................................................................................................................55-92 5.1
Global Protein Engineering Market Forecast
5.1.1
Introduction
5.1.2
Global protein engineering market forecast, by geography
5.1.3
Global protein engineering market forecast, by product
5.1.4
Global protein engineering market forecast, by application
5.1.5
Global protein engineering market forecast, by technology
5.2
Market Dynamics - Overview
5.2.1
Drivers – description
5.2.2
Drivers’ impact – timeline
5.2.3
Restraints – description
5.2.4
Restraints impact – timeline
5.2.5
Opportunities – description
5.2.6
Threats – description
5.2.7
Pestle analysis
5.3
Market Segmentation, by Product
5.3.1
Insulin analogs
5.3.1.1 Insulin analog market 5.3.1.2 Insulin analog market, by geography
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BT 1358 | 2013
Protein Engineering Market - Global Forecast To 2017
Table of Contents 5.3.1.3 Market share analysis 5.3.2
Modified EPO
5.3.2.1 Modified EPO market 5.3.2.2 Modified EPO market, by geography 5.3.3
Monoclonal antibodies (mAb)
5.3.3.1 Monoclonal antibodies market 5.3.3.2 Monoclonal antibodies market, by geography 5.3.3.3 Monoclonal antibodies market, by application 5.3.3.4 Major products in the market 5.4
Other Proteins
5.4.1
Other proteins market
5.4.2
Other proteins market, by geography
5.4.3
Diagnostic proteins, by geography
6. Geographic Analysis .............................................................................................................................................................114-118 6.1
North America
6.2
Europe
6.3
Asia
6.4
RoW
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BT 1358 | 2013
Protein Engineering Market - Global Forecast To 2017
Table of Contents 7. Technology And Product Portfolio .......................................................................................................................................101-105 7.1
Proprietary Technology Platforms
7.2
Product Pipeline Analysis of Key Players
8. Competitive Landscape ......................................................................................................................................................106 - 111 8.1
Introduction
8.2
Porter’s Five Force Analysis
8.3
Mergers & Acquisitions, 2009 – 2012
8.4
Partnerships & Collaborations, 2012 - 2013
8.5
New Product Launch, 2010 – 2012
9. Analyst Insights and Recommendation ............................................................................................................................112 - 114 9.1
Strategic Recommendations
10. Company Profiles ................................................................................................................................................................115 - 146 (Overview, financials, products & services, strategy, and developments) 10.1 Genentech, Inc. 10.2 Amgen, Inc.
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BT 1358 | 2013
Protein Engineering Market - Global Forecast To 2017
Table of Contents 10.3 Biogen Idec, Inc. 10.4 Novartis AG 10.5 Glaxo Smithkline Plc 10.6 Eli Lilly & Co 10.7 Bristol Myers Squibb Co. 10.8 Johnson & Johnson 10.9 Merck & Co., Inc. 10.10 Sanofi 10.11 Pfizer, Inc. 10.12 Regeneron Pharmaceuticals, Inc. 10.13 Eleven Biotherapeutics (U.S.) 10.14 ToolGen, Inc. (Korea) 10.15 DNA2.0, Inc. (U.S.) 10.16 AvidBiotics Corp. (U.S.) 10.17 Sigma-Aldrich Corp. (U.S.) 10.18 Xencor Inc. 10.19 Morphosys *Details on Financials, Product & Services, Strategy, & Developments might not be captured in case of unlisted companies.
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BT 1358 | 2013
Protein Engineering Market - Global Forecast To 2017
List of Tables Table Titles ............................................................................................................................................................Page No 1
Global Protein Engineering Market Revenue, 2012 - 2017 ($Billion)
57
2
Global Protein Engineering Market, by Geography, 2012 - 2017 ($Billion)
58
3
Global Protein Engineering Market, by Product, 2012 - 2017 ($Billion)
60
4
Global Protein Engineering Market, by Application, 2012 - 2017 ($Billion)
62
5
Global Protein Engineering Market, by Technology, 2012 - 2017 ($Billion)
64
6
Insulin Analogs Market, by Geography, 2012 - 2017 ($Billion)
76
7
Modified EPO Market, by Geography, 2012 - 2017 ($Billion)
80
8
mAb Market, by Geography, 2012 - 2017 ($Billion)
83
9
mAb Market, by Application, 2012 - 2017 ($Billion)
85
10
Other Proteins Market, by Geography, 2012 - 2017 ($Billion)
89
11
Diagnostic Proteins Market, by Geography, 2012 - 2017 ($Billion)
91
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BT 1358 | 2013
Protein Engineering Market - Global Forecast To 2017
List of Figures Figure Titles ..........................................................................................................................................................Page No 1
Global Protein Engineering Market, 2012 - 2017 ($Billion)
25
2
Global Protein Engineering Market, 2012 - 2017 ($Billion)
56
3
Global Protein Engineering Market, by Geography, 2012 (%)
58
4
Growth Rate, by Geography, 2012 - 2017
58
5
Global Protein Engineering Market by Geography, 2012 - 2017 ($Billion)
59
6
Global Protein Engineering Market, by Product, 2012 (%)
60
7
Growth Rate, by Product, 2012 - 2017
60
8
Global Protein Engineering Market, by Product, 2012 - 2017 ($Billion)
61
9
Global Protein Engineering Market, by Application, 2012 (%)
62
10
Growth Rate, by Application, 2012 - 2017
62
11
Global Protein Engineering Market, by Application, 2012 - 2017 ($billion)
63
12
Global Protein Engineering Market, by Technology, 2012 (%)
64
13
Growth Rate, by Technology, 2012 - 2017
64
14
Global Protein Engineering Market, by Technology, 2012 - 2017 ($Billion)
65
15
Market Share Analysis
75
16
Insulin Analogs Market, by Geography, 2012
76
17
Insulin Analogs Market, by Geography, 2012 - 2017 ($Billion)
77
18
Market Share Analysis, Key Players, 2012
78
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BT 1358 | 2013
Protein Engineering Market - Global Forecast To 2017
List of Figures Figure Titles ..........................................................................................................................................................Page No 19
Market Share Analysis of EPO, by Product, 2012
79
20
Modified EPO Market, by Geography, 2012
80
21
Modified EPO Market, by Geography, 2012 - 2017 ($Billion)
81
22
Market Share Analysis of Engineered Therapeutic Proteins, by Product, 2012
82
23
mAb Market, by Geography, 2012
83
24
mAb Market, by Geography, 2012 - 2017 ($Billion)
84
25
mAb Market,by Application, 2012
85
26
mAb Market, by Application, 2012 - 2017 ($Billion)
86
27
Market Share Analysis of Other Proteins, 2012
88
28
Other Proteins Market, by Geography, 2012
89
29
Other Proteins Market, by Geography, 2012 - 2017 ($Billion)
90
30
Diagnostic Proteins Market, by Geography, 2012
91
31
Diagnostic Proteins Market, by Geography, 2012 - 2017 ($Billion)
92
32
Product Pipeline of Key Players
105
33
Growth Strategies
107
34
Amgen, Inc., Total Revenue
119
35
Biogen Idec, Inc., Total Revenue
121
36
Novartis AG, Total Revenue
123
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BT 1358 | 2013
Protein Engineering Market - Global Forecast To 2017
List of Figures Figure Titles ..........................................................................................................................................................Page No 37
Glaxo Smithkline Plc, Total Revenue
125
38
Eli Lilly & Co., Total Revenue
127
39
Bristol Myers Squibb Co., Total Revenue
129
40
Johnson & Johnson , Total Revenue
131
41
Merck & Co., Inc., Total Revenue
133
42
Sanofi , Total Revenue
135
43
Pfizer, Inc., Total Revenue
137
44
Regeneron Pharmaceuticals, Inc., Total Revenue
139
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BT 1358 | 2013
Protein Engineering Market - Global Forecast To 2017
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BT 1358 | 2013
Protein Engineering Market - Global Forecast To 2017
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BT 1358 | 2013
Protein Engineering Market - Global Forecast To 2017
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