EDNF 2011 Conference
8/2/11
A Primer on Pain Medications Howard P. Levy, M.D., Ph.D. Assistant Professor, Johns Hopkins University July 21-22, 2011 Ehlers Danlos National Foundation 2011 National Learning Conference Baltimore, MD
Pain
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EDNF 2011 Conference
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Miracle Chocolate Pill
• • • •
Brings you back from almost dead Take as needed Works fast No side effects
“You can’t always get want you want” -Mick Jagger, 1969
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EDNF 2011 Conference
8/2/11
“But if you try sometimes, you might find, you get what you need” -Mick Jagger, 1969
Pain Med Principles • Easier to prevent than get rid of pain § Scheduled, preventive medication more effective than as-needed • Goal is to limit, not eliminate pain • Cocktail of multiple medications § Incremental benefits § Synergies § Maximize safer meds § Minimize riskier meds
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EDNF 2011 Conference
8/2/11
Tylenol® (acetaminophen) • Relatively weak by itself • Can provide incremental pain reduction • Augments other meds • Regular standing dose, not just as
needed • Very well tolerated, few side effects
Tylenol® (acetaminophen) • OTC: 3 strengths § Regular = 325 mg (3 tabs = 975 mg) § Extra = 500 mg (2 tabs = 1000 mg) § Arthritis = 650 mg (2 tabs = 1300 mg) • Max safe dose 4000 mg/day § 975 mg or 1000 mg 4 times/day § 1300 mg 3 times/day
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EDNF 2011 Conference
8/2/11
Tylenol® (acetaminophen) I thought 2000 mg was the max? • White lies: up to 4000 mg/day is safe • Found in many OTC meds • Accidental overdose is too common • READ ALL LABELS § acetaminophen § APAP § paracetamol § “non-aspirin”
NSAIDs • Non-Steroidal Anti-Inflammatory Drugs • Reduce pain (incremental effect) • Reduce inflammation • Regular standing dose, not just as
needed
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EDNF 2011 Conference
Side effects • Gastritis:
8/2/11
NSAIDs
§ Take w/food and/or antacids
• Bruising: Usually just cosmetic § Rarely significant bleeding • Blocks cardiac benefit of aspirin § Wait 2 hours • Heart attack, kidney disease § Rare, mainly w/high dose & prolonged use
NSAIDs Generic name ibuprofen (OTC)
Brand name Advil®, Motrin®
ibuprofen (Rx) naproxen (OTC)
200-800 mg 4 times/day 600-800 mg 4 times/day
Aleve®
naproxen (Rx)
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Typical Adult Dosing
220-440 mg 3 times/day 500 mg 3 times/day
meloxicam (Rx)
Mobic®
7.5 mg twice daily OR 15 mg once daily
nabumetone (Rx)
Relafen®
500 mg 3 times/day OR 750 mg twice daily
diclofenac (Rx)
Flector® Patch
1 patch twice daily
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EDNF 2011 Conference
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Cox-2 Inhibitor • CycloOXygenase 2 inhibitor § More targeted than NSAIDs • Reduce pain (incremental effect) • Reduce inflammation • Regular standing dose, not just as
needed
• No stronger or weaker than NSAIDs • Different side effect profile
Cox-2 Inhibitor
Side effects • Gastritis: Less common than NSAIDs • Bruising: Less common than NSAIDs • Blocks cardiac benefit of aspirin § Wait 2 hours
• Heart attack § More common than NSAIDs, but still rare § Mainly w/high dose & prolonged use
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EDNF 2011 Conference
8/2/11
Cox-2 Inhibitor Generic name celecoxib(Rx)
Brand name Celebrex®
Typical Adult Dosing 100-200 mg 1-2 times/day
Topical Lidocaine (Lidoderm®) • Anesthetic: local pain control • Few side effects § Local rash/skin irritation • Up to 12 hours/day • Up to 3 patches at a time • Can cut patches
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EDNF 2011 Conference
8/2/11
Skeletal Muscle Relaxers • Reduce spasm § Less pain § Possible ↑ laxity • Sedation is most common side effect § metaxolone may be least sedating • Standing or as-needed dosing § Especially bedtime
Skeletal Muscle Relaxers Generic name
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Brand name
Typical Adult Dosing
metaxolone (Rx)
Skelaxin®
400-800 mg 1-3 times/day
cyclobenzaprine (Rx)
Flexeril®
5-10 mg 1-3 times/day
orphenadrine (Rx)
Norflex®
100 mg twice daily
baclofen (Rx)
Lioresal®
5-10 mg 1-3 times/day
carisoprodol (Rx)
Soma®
350 mg 3-4 times/day
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EDNF 2011 Conference
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Neuropathic Pain • Antiseizure medications • Tricyclic (& tetracyclic) antidepressants • SNRI antidepressants
Antiseizure Medications • Suppress undesired nerve signaling • Can prevent/reduce migraines • Side effects § Sedation § Dizziness § GI upset • Gradual dose increase minimizes side
effects • Regular standing dose
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EDNF 2011 Conference
8/2/11
Antiseizure Medications Generic name
Brand name
Typical Adult Dosing
gabapentin (Rx)
Neurontin®
300-1200 mg 3 times/day
pregabalin (Rx)
Lyrica®
25-100 mg 2-3 times/day
topiramate (Rx)
Topamax®
25-100 mg 1-2 times/day
lamotrigine (Rx)
Lamictal®
25-100 mg 1-2 times/day
Tricyclic Antidepressants • Reduce nerve pain • Can prevent/reduce migraines • Helps treat stress, anxiety, depression • Regular standing dose or as-needed • Sedation is common § Can help treat insomnia § Take at bedtime • Other side effects: § constipation, dry mouth
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EDNF 2011 Conference
8/2/11
Tricyclic Antidepressants Generic name
Brand name
Typical Adult Dosing
trazodone (Rx)
Desyrel®
25-150 mg at bedtime
nortriptyline (Rx)
Pamelor®
25-100 mg at bedtime
amitriptyline (Rx)
Elavil®
10-75 mg at bedtime
• Listed in order of increasing likelihood of side effects • These doses are less than used for primary treatment of depression
SNRI Antidepressants • Serotonin-Neurepinephrine Reuptake
Inhibitors • Cousins of SSRIs
§ (e.g. fluoxetine/Prozac®)
• Also treat stress, anxiety, depression § Full antidepressant dosing • May also help prevent migraines • Regular standing dose
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EDNF 2011 Conference
8/2/11
SNRI Antidepressants Side Effects (most common) • Increased appetite • Sexual dysfunction • May increase suicide risk, esp in teens Venlafaxine (Effexor®): • Requires higher doses for pain benefit • May ↑ blood pressure (good for NMH?) • Only one currently available as generic
SNRI Antidepressants Generic name
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Brand name
Typical Adult Dosing
venlafaxine (Rx)
Effexor XR®
150-225 mg daily
desvenlafaxine (Rx)
Pristiq®
50 mg daily
duloxetine (Rx)
Cymbalta®
30-90 mg daily
milnacipran (Rx)
Savella®
25-100 mg twice daily
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EDNF 2011 Conference
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Opioids (narcotics) • Most potent painkillers available • Treat both myofascial & neuropathic • Many risks & side effects • Best to minimize use § 1st maximize cocktail of all other meds § Add occasional opioids as-needed • If daily doses required, switch to long-
acting form
§ Use short-acting version of same drug for
breakthrough pain
Opioids (narcotics) Side Effects • Severe sedation • Clouded thinking • Disrupted sleep • Urinary retention • Dry mouth • Dizziness “Mostly Dead” • Itching, sweating • Constipation, nausea (worsens IBS)
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EDNF 2011 Conference
8/2/11
Opioids (narcotics) • Tramadol works the same way, with
fewer side effects & problems • Available in combination with acetaminophen (Ultracet®) • Caution when combining with TCA or SNRI antidepressants Generic name
Brand name
Typical Adult Dosing
tramadol(Rx)
Ultram®
50-100 mg 1-3 times/day
tramadol(Rx)
Ultram ER®
100-300 mg daily
Opioids (narcotics) • If tramadol fails, switch to true opioid • Short acting form as needed § available in combination with acetaminophen • Use long acting forms if taking daily § Add short acting version of same drug as needed for breakthrough pain
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EDNF 2011 Conference
8/2/11
Opioids (narcotics) Generic
Short/Long
Typical Adult Dosing
oxycodone
short
5-15 mg 3-4 times daily
oxycodone
long-Oxycontin®
10-60 mg twice daily
morphine
short
10-30 mg 4-5 times daily
morphine
long-MS contin®
15-100+ mg twice daily
morphine
long-Avinza®, Kadian®
10-100+ mg once daily
fentanyl
short-Actiq®
0.2-0.6+ mg 4-5 times daily
fentanyl patch
long-Duragesic®
12-100 mcg/hr every 3 days
Opioids (narcotics) Other problems • Stigma/suspicion of abuse • Target of crime • Written Rx only • Narcotic bowel syndrome § Pain stimulation exceeds pain reduction § Especially abdominal, possibly other areas § Hard to distinguish from IBS/other GI prob’s
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EDNF 2011 Conference
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Opioids (narcotics) Addiction? • Tolerance: need ↑ dose for same effect • Dependency: withdrawal sx’s if stopped • Addiction: § take for reasons other than pain
(“I just feel better”) § modify actions to get more drug
Summary • Cocktail of multiple meds • Incremental effects • Maximize safer, less potent drugs • Regular schedule to keep pain controlled • Use opioids as last resort & try to limit
use to no more than a few years
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