#90 SPRING 2017
Benefits go further than food Menzies research looking at school breakfast programs reveals their broader impact.
Thank you! You have made a difference by helping us raise over $44,000 towards multiple sclerosis research through the Winter Appeal.
Michelle Kilpatrick
Schools are an important setting for promoting healthy eating but evidence about the value of school breakfast programs has been mixed. Researchers looked at five Tasmanian primary schools, speaking to parents and carers, students, teachers and volunteers about what they believed to be the benefits of the programs. The lead researcher on the study, Dr Kylie Smith, said the common assumption was that breakfast programs were a good idea for nutritional reasons, but in fact it was social benefits that were consistently named as a major benefit of offering breakfast at school. “These social benefits included the chance for children to interact with children from different grades as well as the adults involved
Healthy habits: Lucas, George and Charlotte, from Moonah Primary School in Hobart, tuck into their school breakfast.
in running the program, engagement between the school and the community, and an opportunity for the school to provide early intervention and support for families,” Dr Smith said. She said the way the breakfast programs were run varied across the five schools, but all schools reported social benefits. Researchers conducted
Children are not necessarily missing breakfast at home for economic reasons written surveys and spoke to parents, staff, students and volunteers through one-on-one interviews and focus groups. They looked at five primary schools in Southern Tasmania across different geographic settings (some rural, some urban) and with different
demographic profiles. Dr Kim Jose, Ms Miriam Vandenberg, Professor Joan AbbottChapman and Professor Alison Venn also contributed to the report, which was funded by the Research Enhancement Grant Scheme at the University of Tasmania.
MULTIPLE SCLEROSIS
This will make a significant impact in securing a multiple sclerosis fellowship for our flagship program.
New funding accelerates progress in research
If you would like to make a donation to the multiple sclerosis appeal or to another area of research at Menzies, either go to the “donate” tab at menzies.utas.edu.au, fill out and return the donation slip in this Bulletin or call 1800 638 124 or 6226 7700.
An innovative multiple sclerosis research fellowship designed to fast-track scientific knowledge into clinical practice has been awarded to two Menzies researchers. The Director of Menzies, Professor Alison Venn, said the inaugural MS Research Australia – Macquarie Group Foundation Paired Fellowship program totalling $750,000 for three years, was
visionary in the way it brought laboratory and clinical researchers together to speed up the translation of research into practice. “We are very proud that two of our senior scientists have been chosen through a competitive process to achieve this, the only nationally funded paired fellowship in multiple sclerosis (MS) research,” Professor Venn said. “We have 20 years of research into multiple sclerosis at Menzies and this disease is a key area of focus for us. This funding will allow us CONTINUED ON PAGE 3
Menzies Bulletin Spring 2017 1
Welcome to the Menzies Bulletin for spring The work on building our flagship multiple sclerosis program has been our focus over winter and early spring. It culminated in us joining forces with the Parliamentary Friends of MS group for a briefing of Federal politicians in Canberra on September 7.
We are also strengthening our focus on... having research put into practice as quickly as possible
We have a large number of staff, led by researchers who are international leaders in their fields, committed to MS research. Our ultimate aim is to find a cure for this terrible disease, but there are many rivers to cross before we reach that point. Our focus in the short term is to build our work, as quickly as possible, in preventing MS, delaying the progression of the disease and finding out more about how to keep those with the disease leading rich and fulfilling lives.
We are also strengthening our focus on translational research – this means having research put into practice as quickly as possible. As we strengthen our efforts in MS we are extremely grateful to have funding from MS Research Australia, the NHMRC and recently the Macquarie Foundation, through the innovative Paired Fellowship (see page 3). Working with MS Australia and Senators David Bushby and Deborah O’Neill, convenors of the Parliamentary Friends of MS, is a vital and enjoyable part of our mission in this area.
On a sadder note, we have recently become aware that a person of great importance to Menzies’ early years died late last year. Jean Trethewey was a member of the Board of the Menzies Centre for Population Health Research (as we were then) for three years and Chair of the Board for nine years. Jean provided the drive to take Menzies from a successful but modest-sized medical research organisation to a major entity providing opportunities for young Tasmanians and others to become genuine contributors to world-class research. We are saddened to hear of Jean’s death and will remember her contribution with gratitude. Kind regards,
Professor Alison Venn Director
BLOOD PRESSURE
Study highlights need to improve accuracy in blood pressure A comprehensive analysis of blood pressure data from the 1950s to the present day has highlighted the need for improvement in the accuracy of blood pressure measuring.
Researchers analysed almost seven decades of international data 2
Menzies Bulletin Spring 2017
measured simultaneously with an upper arm cuff and with a catheter inside the artery either at the arm or at the aorta (the gold standard reference method). They found much lower certainty that cuff measurements were accurate in those people whose blood pressure was in the mid-range than those whose cuffmeasured blood pressure was either low or high. The leader of blood pressure research at Menzies, Professor James Sharman, stressed that the findings did not mean that people should stop taking their medication or stop having their blood pressure measured with the cuff device.
Peter Mathew
Researchers at Menzies found significant uncertainty in the accuracy of blood pressure measured with an upper arm cuff in those people with midrange blood pressure (the most common range). The study was published in May in the Journal of the American College of Cardiology. To undertake the study researchers analysed almost seven decades of international data on 2500 people who had had their blood pressure
Finger on the pulse: PhD student Dean Picone has been recognised for his achievements in blood pressure research.
STUDENT OPENS DEBATE ON BLOOD PRESSURE Menzies PhD student Dean Picone is the recipient of the Australian Society for Medical Research (ASMR) Tasmanian Postgraduate Student Award. As part of national Medical Research Week 2017, the ASMR invited health science postgraduate students to submit an abstract of their research. The top six were then invited to present their research before a judging panel. The judges were impressed with the universal relevance of Mr Picone’s research, which looked at the accuracy of blood pressure measurements done with the traditional upper arm cuff. Mr Picone is supervised by Menzies Deputy Director Professor James Sharman.
MULTIPLE SCLEROSIS
Talent times two: Professor Bruce Taylor and Dr Kaylene Young in the laboratory at Menzies.
Miranda Harman
NEW FUNDING WILL ACCELERATE PROGRESS... CONTINUED FROM PAGE 1
to bring together two different streams of research that are investigating the disease. I would like to express our gratitude to MS Research Australia and the Macquarie Group Foundation for providing such an exciting opportunity.” The fellowship has been awarded to Professor Bruce Taylor, a clinical researcher at Menzies and a neurologist at the Royal Hobart Hospital, and Dr Kaylene Young, a neuroscientist who has dedicated her career to studying the brain’s ability to repair itself through cellular processes. Dr Matthew Miles, CEO, MS Research Australia, said: “Our new and innovative grant program launches a unique opportunity. It addresses one of the key recommendations identified in the 2013 McKeon
Review into Health and Medical Research; that far more clinicians need to participate in the research process. This fellowship will also break down the barriers between the lab and the clinic and ensure faster translation of research discoveries into tangible health benefits for the community. “We understand this to be the first research practitioner/ researcher fellowship fully funded by philanthropy and the community. We are thrilled
This fellowship will ensure faster translation of research discoveries into tangible health benefits for the community
that Dr Kaylene Young and Professor Bruce Taylor are the inaugural recipients. Their research will help expedite new treatments to protect and repair the nervous system, something that is desperately needed for people with MS.” Professor Taylor and his team have identified genetic mutations that they believe increase a person’s risk of developing MS, or in some cases may cause MS. Professor Taylor said the new research would move those discoveries into the laboratory environment to find out how the mutations affect cell health. “That knowledge can help us re-purpose existing drugs that could offset the effect of the mutation, and could be used in future clinical trials,” Professor Taylor said. Dr Young has discovered that non-invasive brain stimulation, known as transcranial magnetic stimulation (TMS), can increase the ability of stem cells in the brain to generate new cells for nervous system repair. This fellowship will allow her to move this work into the early stages of clinical research. “We will perform a safety trial of TMS to ensure that this potential treatment can be safely administered to people with MS,” Dr Young said.
Facts about multiple sclerosis M S affects one in 1,000 Australians or 23,000 Australians T asmania has Australia’s highest prevalence of people with MS M S is more common in women by a ratio of 3:1 M S is the single greatest non-traumatic cause of neurological disability in young adults M S affects people during the most productive periods of their lives M S significantly reduces quality of life and productivity T he time required to translate a discovery in the laboratory or from clinical research into outcomes for people with MS is often greater than 10 years A t the moment no mechanism exists in Australia or internationally to significantly shorten this time M S is currently incurable
Turning research into practice Menzies is working on the development of a flagship program of research in multiple sclerosis (MS) with a focus on the rapid translation of research into clinical practice. Our plans include the establishment of an internationally accessible MS research translation centre to bring together researchers, people living with MS, clinicians, caregivers, allied health professionals, policy makers and service providers. This type of integrated facility does not currently exist in Australia. Menzies and the Parliamentary Friends of MS, led by Senators
David Bushby and Deborah O’Neill, held a briefing in Canberra in September to outline Menzies’ aims in this
area to Federal Members and Senators. Professor Bruce Taylor, health economist Professor Andrew Palmer, MS epidemiologist Associate Professor Ingrid van der Mei and Institute Advancement Manager Magdalena Lane spoke at the briefing about Menzies’ research and our hopes for this program.
Menzies and the Parliamentary Friends of MS hosted a briefing for Members and Senators in Canberra in September.
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RESEARCHER PROFILE
Dr Ricardo Fonseca Post-Doctoral Research Fellow
You joined the Menzies staff as a Postdoctoral Research Fellow recently... What were you doing before this? I have been at Menzies since late 2013 as a PhD student. I came to Australia in 2011 to improve my second-language skills, and before that I was working in Colombia as a physician and medical auditor.
What is the current focus of your research? This is a transition time in my career. During my PhD I investigated the appropriate use of health services, specifically cardiac imaging. However now, as part of the Blood Pressure Group, I will focus on the clinical and economic implications of some of the methods used in detection and management
of hypertension and cardiovascular risk assessment. What is the biggest challenge in your area of research? I believe the biggest challenge in my area of work is translating research into practice. This might mean, for example, making sure that patients know that sometimes not having a particular test is the best course of action. It could mean encouraging a physician to reflect on the real impact an examination or requested service had on their medical decisions – did the results actually change their preestablished ideas of treatment? I am not only talking about the overuse
of health services and the consequent risk for patients but about underuse and importantly, the impact that our decisions have on the health system budget.
We use amazing software... for very complex explorations What is the most interesting aspect of your work? When I was studying medicine, not long ago, I remember I received classes in biostatistics. We used tables in books, and the analyses were made with calculators. Nowadays
we use amazing software; not only for simple statistical analysis but for very complex explorations and complicated figures that were almost impossible to do some years ago. The software I am using for my statistical analyses is called R. It has awakened my “mathematics” and “designer” skills! I just started to use another software called TreeAge. I’m hoping I’ll find that one mesmerising too! What do you enjoy doing in your spare time? Apart from hiking, reading and cooking, I like naps. It is something I miss a lot. I tend to have naps after lunch when I am not working.
Scholarships support the next generation New Menzies PhD and Honours students, staff and supporters gathered for morning tea to celebrate the generosity of the individuals and organisations who support the next generation of Menzies researchers through scholarships. This support is invaluable to the Institute. In 2017, Menzies has almost 70 research academics who supervise nearly 100 PhD and Honours students. Many of these students are the beneficiaries of philanthropic donations that help meet their living expenses so that they can fully concentrate on
Thanks to you: TasNetworks representatives with Menzies researcher Michelle Kilpatrick; Anita, Norma and Murray Gordon with Brooklyn Fraser (second from right) who is supported by the Patricia F Gordon scholarship in medical research.
full-time study. In her thank you to supporters the Menzies Director, Professor Alison Venn, said about 13 per cent of the Institute’s income comes from philanthropy. “We now
Tassie technology helps Canberrans breathe easier The AirRater smartphone app developed by a team led by Dr Fay Johnston has launched in the ACT. Until now AirRater had only been available in Tasmania. The
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app provides users with real-time, geographicallyspecific information on pollen, air pollutants and temperature. It was launched in the
Menzies Bulletin Spring 2017
have over 30 scholarships for research students enabled by the generosity of our supporters.” During the event, new PhD and Honours students had the opportunity to meet the
ACT on the eve of National Asthma Week. This app provides free and practical advice for people with asthma, hay fever and other lung conditions. The Member for Murrumbidgee, Chris Steel, launched the app. “For many people
individuals and organisations who sponsored their study. These relationships often remain relevant and strong over the course of the students’ studies, sometimes even for life.
in our community who suffer with asthma or other chronic respiratory illnesses, this app will help them to be more aware of air quality in their region,” he said. The ACT AirRater app uses data from three air
quality monitoring stations in Canberra, pollen counts monitored at the Australian National University and Bureau of Meteorology weather monitoring information. AirRater has been running in Tasmania since 2015.
Menzies debate Once again we had around 200 people at the Medical Science Precinct for this year’s Menzies Debate, which was on the topic ‘Heart Disease? We Don’t Need to Worry About That Anymore’. The overwhelming majority of the audience disagreed with this assertion, although quite a few were swayed from one side of the argument to the other by the debate, which was expertly
moderated by Bernie Hobbs of ABC Science. It was a lively discussion on a provocative question and here’s our footnote to the event: at Menzies we definitely believe that we still need to worry about heart disease – it is, after all, the leading cause of death worldwide. Thanks again to all who came along and to our excellent panel of debaters for embracing the spirit of the evening.
WATCH IT ONLINE Catch up with the 2017 Menzies Debate by going to the video section of our Facebook page: www.facebook.com/ MenziesResearch/
Bright sparks: Bernie Hobbs from ABC Science (above) was our guest moderator for the 2017 Menzies Debate. Guests enjoyed drinks and canapes before the action got under way.
STUDIES RECRUITING PARTICIPANTS The Menzies Blood Pressure Clinic is a community service offered to help improve the care of people with problems related to high blood pressure. The clinic uses the latest methods dedicated to the investigation and management of high blood pressure. People referred to the clinic undergo various blood pressure tests, as well as comprehensive risk assessments. A report is then sent to the referring GP detailing blood pressure measures together with a suggested treatment regimen. All services are bulk-billed. PPMS: Primary Progressive MS Study into risk factors for the onset and rate of progression of Primary Progressive MS. Contact: Susan Dobson 6226-4269 or ppms.study@utas.edu.au, or visit www.menzies.utas.edu.au/PPMS AirRater is recruiting Tasmanians with asthma, hay fever or other lung conditions, or carers of those with these conditions. Contact: air.rater@utas.edu.au or 1800 322 102 AMSLS: The Australian MS Longitudinal Study to provide data of practical use for improving the lives of Australians living with MS.
Keep up with our news
Contact: Kirsty Hawkes 6226-4739 or AMSLS.info@utas.edu.au, or visit www.msra.org.au/AMSLS The OMM Study: developing a questionnaire for mindfulness research. Participants will have either already done, or be signed up to do a mindfulness course. Contact: mindfulness.study@utas.edu.au or call 6226-4723 KAROAKE: A randomised trial of krill oil for osteoarthritis of the knee to examine use of krill oil to improve knee pain and slow down progression of knee osteoarthritis. Participants must be aged 40 years or more, have significant knee pain and swelling most days for at least six months, and able to have a knee MRI. Contact: Carole Goff 6226-7648 or Carole.Goff@utas.edu.au Genetics of Eye Diseases for genetic studies in diabetic retinopathy (participants should have Type 2 Diabetes treated with medication for at least 5 years, or Type 1 Diabetes); keratconus (participants should have keratoconus diagnosed by an optometrist or ophthalmologist); and advanced glaucoma (participants should have any type of
glaucoma with severe vision loss treated by an ophthalmologist). Contact: maria.cooper@dhhs.tas.gov.au or 6226-4731 INVEST: INvestigating obEsity Surgery in Tasmania. Participants need to have been referred to a surgeon for weight-loss surgery. Contact: Dr Michelle Kilpatrick 6226-4630 or obesitysurgery.study@utas.edu.au STAREE: STAtins in Reducing Events in the Elderly investigating whether a statin can prolong good health and maintain independence among people aged 70 and older. Contact: staree@monash.edu or 1800 770 664 Caught-CAD: Reducing Risk of Coronary Artery Disease in Families is looking for people who are between 40-70 years; have a close family member (parent, brother or sister) who has had a heart attack, stent or surgery under the age of 60, and are not currently taking a statin. Contact: Kristyn Whitmore 6226-4235 or Menzies.CAUGHT@utas.edu.au
Would you like to keep up to date with the latest Menzies news? Find us on Facebook and ‘Like’ our page. You can read all of our Bulletins and reports electronically at issuu.com.
Menzies Bulletin Spring 2017 5
Winners are grinners: Patricia Graham, Lauren Roman and Yan Zhang.
Three-minute maestros make their mark Menzies PhD students Patricia Graham and Yan Zhang were both winners in this year’s University of Tasmania Three-Minute Thesis (3MT) competition held
during Research Week (September 4-8). Patricia’s presentation, titled “Gene hunting: Unravelling the causes of glaucoma blindness” received first prize
overall. Patricia is a student with Associate Professor Kathryn Burdon. She will now represent the University of Tasmania at the Asia-Pacific 3MT event at the University of Queensland. Yan Zhang, a student with Associate Professor Ingrid van der Mei, won the People’s Choice Award for her presentation “Better understanding of progressive Multiple Sclerosis (MS)”. Patricia and Yan are pictured with the runner-up, Lauren Roman (centre), from the University’s Institute for Marine and Antarctic Studies. You can view the presentations at http://www.utas.edu.au/researchadmin/graduate-research/ research-training-opportunities/ three-minute-thesis-3mt#
PROFESSOR SMALL HANGS UP LAB COAT Professor David Small, who is an international leader in Alzheimer’s disease research, has retired from full-time work at Menzies. Professor Small joined the University of Tasmania in 2008 and is well-known internationally for his work on the molecular neurobiology of Alzheimer’s disease. His work has assisted in re-interpretation of existing drug targets and the identification of new drug targets. He published almost 200 refereed papers, supervised many PhD, Masters and Honours students and contributed to the teaching of university biochemistry and neuroscience. Professor Small said the greatest pleasure for him was the opportunity to interact with colleagues and to develop close friendships. “I have enjoyed my time at Menzies very much and I look forward to maintaining contact,” he said.
THANK YOU TO ALL OF OUR DONORS FOR YOUR ONGOING FINANCIAL SUPPORT AND COMMITMENT TO MENZIES The following individual and community supporters donated for the first time between May and early September, 2017. Dent Tech Tasmania Franklin Restaurant Mrs Susan Abey
Mr Dominic Baker Mr David J Bartlett Ms Lyn Bowes
Ms Mary Bracken Sam Broadrib Ms Renee Burgess Mr Todd Burrows Mrs Margaret Dall’Ozzo Mr George Giameos
Listed below are our Everyday Angels – our supporters who make regular gifts to Menzies.
Mrs Anita Clarkson Mr Peter Cochrane & Mrs Miranda Harman Mr A M Cornish AO Mr Robert D M Cotgrove Mrs Elizabeth Crowther Mrs Brigid Davis Mr Jonothan & Mrs Diane Davis Ms Moya T Deigan Mrs Julie Duff Mr Laurence C Dunn Ms Carolyn Dunnewijk Mrs Patricia M Edwards Mr Josh & Mrs Felicity Ey Dr Derek Findlay Mr Peter Fountain Mrs Beverley Geard Mr Don & Mrs Margaret Goff Mr John Goodwin Mr G & Mrs J Goss
Mrs Judy Grant Mr Garth & Mrs Brenda Haas Mrs Susan Haigh Mr Philip Hand Ms Alicia Hansen Ms Tess Harvey-Mount Ms Judith Hastie Mrs Shirley Heath Miss Judy Hebblethwaite Ms Alison Hennessy Ms Kathryn Hill Mrs Susan L Hinds Ms Di Hodel Mr Geoffrey Holloway Mr John W Hudson Ms Shelley Hunter Ms Carol Hurst Mr Gary & Mrs Susan Jacobson Ms Anne James Mrs Wendy Jefferies Mrs Wendy Jennings Mr Raymond & Ms Dianne Jones
Hypertronics Tasmania Mr Timothy Albion Mrs Teisha Archer Dr Gregory S Austin Mrs Jennifer B Banks Mrs Jan Barren Mrs Larissa Bartlett Ms Janet Beadle Mrs Kathleen Bevis Mrs Pamela Blunt Mrs Pam Bowles Ms Kathleen Brient Dr Catherine M Bulman Mrs J Burrell & Mr L Sokvitne Ms Jill M Cassidy Dr Susan R Cherry Mr Tim and Mrs Emma Claridge
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Menzies Bulletin Spring 2017
Mr Doug Gibson Mrs Patricia Hennessy Mrs Kathryn Laing Ms R Lipscombe Mrs Mary McIntosh Mr Brett McKay Mr Greg McKibbin Mrs Margaret & Mr Alan Keogh Ms Margaret Knight Ms Sabina Lane Mrs Terry & Mr Ian Law Ms Anne L Le Clerc Ms R Lipscombe Mrs Jane Lovibond Mr David T MacLeod Mrs Marie Magill Mrs Betty M Marshall Ms Kathryn Marthick Mr Dugald McDougall Mr Marcus McEwan Mrs Helen McKibben Mrs Frances Joan McKinlay Ms Kate McQuaid Mrs Philippa Micklem Mr Sam Mollard Mr Peter Morgan Mr Bill Napier Ms Wendy Noye Mrs Astrid A O’Toole Mrs Sally Oakley
Mrs Alison O’May Mrs Lyndal Phillips Ms Nicole Reily Mr Graham Robertson Mrs Lynette Rose Ms Julie Ryan Mr Regan Shaw Mrs Jennifer A Parsons Miss Alison Parsons Kim Paterson Mrs Glenda Paton Mrs Pauline Payne Mr Andrew J Pitt Ms Alison J Poortenaar Mr Nathan Porter Mrs Cleone M Probert Mrs Pamela Rabbidge Mr Alan L & Mrs Jancis Rees Mrs Bronwyn E Reynolds Mrs Margaret J Richardson Ms Monica Richardson Mr Eric & Mrs Jill Robinson Mrs Frances M Russon Mr Patrick Sampson Mrs Jennifer & Mr Ian Scott
Mrs Merle Smith Ms H R Smith Mrs Ellen J Stagg Mrs Elizabeth Taylor Mrs Rita Van Meer Mr Don White Mr Michael Williams Mrs June Scott Ms Patricia J Shires Mrs Susan Sluce Mrs Gwynneth & Mr Richard Sperring Mr Alex Stanelos Mr David Steward Mrs Patricia Stokes Miss Amber C Sturges Ms Carmel Taylor Mrs Cynthia Tennant Mr Arturo Thomas Mrs Brenda Triffitt Mr David Tulip Mrs Rosemary Van den Berk Mr Walter & Mrs Robin Verth Mrs Anne Warren Mr Peter Weldon Mr John Wheatley Ms Barbara White Mrs Thurza Whiting Mrs Nancy Williams Ms Janice Wilson Mrs Elizabeth Woolley
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In Memoriam May 2017 to early September 2017
One sentence in your Will can fund life-saving medical research. If you would like more information, please contact the Institute Advancement Manager on 03 6226 4236. Bequests save lives by funding research. Thank you.
We gratefully acknowledge gifts made in honour of: Mrs Arthur Bealey Mr Donald Considine Mr John B Coulson Mrs Beverley Culph Ms Carol A Davenport Mr Brian D Elkin Mrs Zelda N Gay Mrs Nellie Grice Mr Geoffrey J Hoare Mr Peter James Mr David H Jones Mrs Eileen King Mr John Macleod Mr Ray Madden-Hallett Mrs Jillian Menadue Mr David Muocahy Mrs Margaret Phillips Mrs Cynthia Rutledge Mr Colin D Sherriff Mrs Marlene M Smith Mr Lenard J Somers Mr Robert H Stagg Mr Christopher Turner Mrs Joyce Wikeley
We gratefully acknowledge gifts made from the following Estates: Estate of the late Betty June Smith Estate of the late Georgine Mavis Davies Estate of the late Dr Valerie A. Davenport Estate of the late Josephine Marie Denne Estate of the late Dawn Merie Juodvalkis Estate of the late Leslie Charles Adams