Menzies Spring Bulletin 2018 by Menzies Institute for Medical Research

Bulletin #0094

SPRING 2018

A breath of fresh air for lung research Menzies has welcomed Professor Graeme Zosky, a respiratory physiologist, as a Deputy Director of the Institute. Professor Zosky has built a successful research career in Western Australia and Tasmania. His expertise is in building better understanding of the mechanics of how our lungs function. Professor Zosky’s research is clinically relevant in a multitude of ways. “Respiratory infection is the most common reason that young children are hospitalised,” he said. “This is often due to an exacerbation of asthma symptoms, but without knowing more about lung physiology we can’t improve the health of these children. I’d like to think that we can get to the stage where everyone has an equal start to life in terms of their respiratory health.” Professor Zosky collaborates

with critical care specialists at the Royal Hobart Hospital and has experience in the early life determinants of respiratory disease, including post-natal and in-utero exposures. He has also worked on occupational exposures such as coal dust and on other influences on lung health such as vitamin D and arsenic. Because of the large amount of established epidemiological research at Menzies, Professor Zosky is excited by opportunities “to bridge the bio-medicalepidemiological divide”, bringing together research into the

Building lung capacity: Professor Graeme Zosky.

factors that contribute to lung disease (its epidemiology) and his own bio-medical research into lung mechanics. The Menzies Director, Professor Alison Venn, said Professor Zosky’s joint appointment between Menzies and the School of Medicine was exciting for several reasons, among them the opportunity to further integrate research

Without knowing more about lung physiology we can’t improve the health of these children.

and teaching. This integration increases medical students’ access to researchers and lays the foundations of ongoing research for students who become clinicians. The leader of blood pressure research at Menzies, Professor James Sharman, is also a Deputy Director of the Institute. Former Deputy Director Professor Tracey Dickson continues as a research scientist at Menzies and is also now the Associate Dean Research in the broader College of Health and Medicine.

FE L LOW S H I P S

Boost for research into stronger bones and joints Menzies has received Federal Government funding of more than $650,000 that will allow it to extend clinical research into osteoarthritis and osteoporosis. The funding allows Dr Feng Pan to continue work identifying subgroups of clinical osteoarthritis with the aim of developing treatments customised to the subtypes. “Osteoarthritis is a

highly heterogeneous condition and the current ‘one size fits all’ approach to treatment is not working,” Dr Pan said. “We hope to be able to provide evidence that will allow

better treatment to reduce pain, slow the progression of the disease and reduce the burden of the disease overall.” The funding will also enable Dr Feitong Wu to test the efficacy of vitamin D supplementation for improving bone density in children with vitamin D deficiency. Dr Wu is also working

on identifying the modifiable risk factors in early and midlife for conditions such as low bone density, muscle weakness and falls. “This information will have the potential to help delay the onset of osteoporosis and reduce the risk of fractures in later life by intervening at an early stage of life,” Dr Wu said.

Menzies Bulletin Spring 2018

Director’s message Welcome to the 2018 Spring Bulletin One of our highlights of 2018 has been the launch of the first comprehensive analysis in eight years of the cost of multiple sclerosis (MS) in Australia.

This is the first comprehensive analysis in eight years of the cost of MS in Australia

The report, titled Health Economic Impact of Multiple Sclerosis in Australia 2017, was launched by the Hon Scott Morrison in the week he became Australia’s 30th Prime Minister. The report provides new data on the number of people with multiple sclerosis, the costs per person and the total economic costs. It also calculates a measure of the impact of the disease on

quality of life. Calculating and analysing this data provides us with a solid foundation for decisions and actions aimed at improving quality of life for people with MS. The information helps to inform research and funding priorities. It allows a holistic view of the impacts of the disease – for example how these differ between men and women; in metropolitan, regional and

remote settings; between different types of MS and at different stages of the disease. See the opposite page for more information on the report. I would like to offer my congratulations to the team that produced the report, led by Professor Andrew Palmer. Our thanks go to MS Research Australia for providing this opportunity through commissioning and funding the work, and to the Prime Minister, Mr Morrison, for his genuine interest in this vital research area.

Professor Alison Venn Director

2018 Menzies greeting card collection We have great pleasure in presenting this year’s Greeting Card Collection, which features 12 original artworks, kindly donated by acclaimed Tasmanian artists. All proceeds from the sale of this superb collection of cards go directly to supporting medical research at Menzies. Packs of 12 cards are just $10 Simply purchase your cards by: Completing and returning an order form Calling us on (03) 6226 7700 Ordering online at menzies.utas.edu.au, or Visiting us at 17 Liverpool St, Hobart during office hours

Please note that cards will not be available until 26 October 2018, but pre-orders are welcome. Many thanks to our design and print partners – The 20, Mercury Walch and Winc – for their generous support of the collection.

Keen to know more?

We would like to extend a heartfelt thank you to our volunteers for the wonderful work they do at Menzies. Two of our volunteers, Dianne Eggins and Sally Reason, are pictured with the Lord Mayor of Hobart, Alderman Ron Christie, receiving a certificate from the council’s Volunteer Recognition Program, which acknowledges the contribution that volunteers make to the Hobart community. Menzies has about 150 registered volunteers who help us with many tasks in our clinic, in our studies and behind the scenes.

Our corporate publications are available in an easy-to-read PDF format here: issuu.com/menziesinstituteformedicalresearch Annual Report 2017 | Research Highlights 2017 | All previous Bulletins

Would you prefer to receive our publications and invitations by email? If so, simply let us know by sending an email to enquiries@menzies.utas.edu.au. Alternatively, to update postal details please tick the box on the tear-off slip attached to the Bulletin and return it to us. If you use the Reply Paid address at the bottom of the tear-off slip you won’t need a stamp.

Menzies Bulletin Spring 2018

MENZIES MS FLAGSHIP PROGRAM Teamwork: MS Research Australia Head of Research Dr Lisa Melton, left, with Menzies researchers Professor Andrew Palmer and Associate Professor Ingrid van der Mei, and MS Research Australia CEO, Dr Matthew Miles.

Working towards longer and better lives for people with MS The number of Australians living with multiple sclerosis (MS) continues to rise – it’s now at 25,600 – but new treatment strategies mean that more people are able to stay in work and are needing less care and support. This new data is from a comprehensive report prepared by Menzies and launched in August by the then Treasurer, the Hon Scott Morrison. The report, The Health Economic Impact of Multiple Sclerosis in Australia 2017 was commissioned by MS

increase in the number of Australians living with MS

Research Australia and is the first comprehensive analysis in eight years of the cost of MS in Australia. The report suggests that the 20 per cent increase in the number of Australians living with MS is largely due to more people living longer with the disease. Women continue to represent more than three quarters (78 per cent) of those with MS in Australia. Despite the good news on people with MS continuing in the workforce, the report found that costs for those living with more advanced MS are incredibly high, more than triple per person compared to those with milder disease (from $30,561 for people with no disability to $114,813 for people with severe disability). The total economic cost of MS to the community now stands

MS research at Menzies Since 1998 Menzies has been at the forefront of some of the most important advancements in MS research. Menzies researchers and their collaborators have made significant contributions to understanding the genetic, environmental and lifestyle risk factors for both the development and progression of MS.

The Hon Scott Morrison launches the report in August.

We can’t take our foot off the pedal at $1.75 billion – an increase of $0.51 billion since 2010. Menzies health economist Professor Andrew Palmer, who led the team that prepared the report, said the introduction of new disease modifying therapies over the past few years had had a profound effect on the management of the disease and also on the costs of MS. “We can’t take our foot off the pedal, as while there are positive signs, we need to maintain the momentum and continue to make improvements in the management and care of MS, including interventions aimed at stopping the relapses

MS facts

MS is an autoimmune disease where the myelin sheaths covering nerve fibres in the central nervous system are damaged, leading to impairment of motor and/or sensory functions, fatigue, pain and cognitive symptoms. It is the most common non-traumatic neurological condition in young adults. The majority of Australians with MS (85 per cent) are diagnosed with the relapsing remitting form of MS, while 10-15 per cent are diagnosed with a progressive form of MS in which disability accumulates right from the start, even in the absence of acute relapses.

and preventing the progression of MS, so we can reduce the human and economic burden even further,” Professor Palmer said. Lost wages now account for just one third (32 per cent) of the total economic burden of MS compared to almost half (49 per cent) of the overall cost burden seven years ago. The CEO of MS Research Australia, Dr Mathew Miles, said there were positive and clear signs of the potential for people with MS to continue a productive life, remaining well and in the workforce, supporting their families and contributing to society. “While this report shows positive signs and a shift towards improving outcomes, MS remains a very challenging condition, particularly in those with more progressive forms, placing a very significant burden on people and their families. MS is most frequently diagnosed when people are in the prime of their life.” MS Research Australia also supports research at Menzies through post-doctoral Fellowship funding and incubator and travel grants.

Menzies Bulletin Spring 2018

research thanks to you

Fun at work to make the Seconds Count The Menzies Workplace Giving Program is a unique way for employers and employees to support better health outcomes in Tasmania. This year, we welcomed Suncorp to the program. To celebrate the launch of the program, Suncorp’s Hobart-based team partnered with the Seconds Count Gala Ball, which raises money for Menzies research into secondary breast cancer. Suncorp staff held a sunny and tropically themed morning tea and pledged $20,000 to this research, as well as dollar matching pre-tax donations made to Menzies by its employees. There are many ways business and employees can get involved in giving, including employer donation matching, volunteering, sharing skills and expertise and workplace fundraising. For more information on workplace giving please contact: Menzies.Advancement@utas.edu.au or visit menzies.utas.edu.au

A reason to smile: Staff at Suncorp in Hobart enjoy a tropical morning tea.

Morgans Financial in Hobart has donated $5000 to Menzies. On behalf of Morgans, Andrew Inglis explains why... “Something that really interests us is that up to 80 per cent of heart disease and diabetes deaths and nearly 40 per cent of cancer deaths in Australia could be prevented through adopting a healthier lifestyle. This is an alarming public health issue. Menzies is playing an important role in bringing these issues into focus and is involved in a wide range of preventative health research projects in addition to making significant contributions across many other critical health issues.”

Thank you to all of our donors for your ongoing financial support and commitment to Menzies The following individual and community supporters donated for the first time between late May and early August. Ms Bronwyn Burgess Encampment IOOF Mrs Emma Gordon Mr Graham Burgess Ms Evelyn DeVito Ms Christine Hutchison Mrs Jane Butler Dribble and Shake Ms Julene Grace Country Women’s Freeston Family Mrs Marjorie Ingleby Association - Bellerive Glamorgan Spring Ms Michelle Johnston Derwent Valley Bay Council Dr Michael Kilburn

Dr Robert A Kildare Mrs Maisie E Knott Loyal Glenora Lodge IOOF Mrs Andrea Major Mrs L Joan Marten Mr John Mathewson Mr Graham &

Mrs Joy Pepper Ms Engelina Poulton Riders of Tasmania Mr Ian & Mrs Shirley Raine Ms Jan Rooke Ms Tanaya Roy Mrs Jenny Symonds

The Hobart Anaesthetic Group Mr Simon Tyrrell Mrs Suzanne Wolf Mr Christopher M Wootton Dr Rosemary H Yeoland

Listed below are our Everyday Angels – our supporters who make regular gifts to Menzies.

Mr Raymond & Ms Dianne Jones Mrs Margaret & Mr Alan Keogh Ms Margaret Knight Ms Sabina Lane Mrs Terry & Mr Ian Law Ms Anne & Mr Anthony Le Clerc Ms Rebecca Lipscombe Mrs Jane & Mr Nicholas Lovibond Mr David T MacLeod Mrs Marie Magill Mrs Betty M Marshall Mr Dugald McDougall Mr Marcus McEwan Mrs Helen McKibben Mrs Frances Joan McKinlay Ms Kate McQuaid Mrs Philippa Micklem Dr Ken and Mrs Yvonne Milton

Mr Sam Mollard Mr Peter Morgan Ms Wendy Noye Mrs Anita Nutting Mrs Astrid A O’Toole Mrs Sally Oakley Mrs Jennifer A Parsons Miss Alison Parsons Kim Paterson Mrs Glenda Paton Mr Andrew J Pitt Mr Nathan & Mrs Christabel Porter Mrs Pamela Rabbidge Ms Jillian Reade Mr Alan & Mrs Jancis Rees Mrs Margaret & Mr Brian Richardson Mrs Jill & Mr Eric Robinson Mrs Frances M Russon Mrs June Scott Mrs Susan Sluce Mrs Gwynneth &

Mr Richard Sperring Mr Alex Stanelos Miss Amber C Sturges Ms Carmel Taylor Mrs Cynthia Tennant Mrs Brenda Triffitt Ms Karen Twynam-Perkins Mrs Rosemary Van den Berk Mr Walter & Mrs Robin Verth Mrs Anne Warren Mr Peter Weldon Mr John & Mrs Kathlyn Wheatley Mrs Kathryn Whitchurch Ms Barbara White Ms Mandy J Williams Ms Janice Wilson Mrs Elizabeth Woolley Hypertronics Tasmania

Mr Mr Timothy Albion Ms Juliet Allen Ms Anita Allie Ms Kylie Anderson Mrs Teisha & Mr Aaron Archer Mrs Jennifer & Mr Lionel Banks Ms Jess Bannister Mrs Jan Barren Mrs Larissa & Mr David Bartlett Ms Janet Beadle Mrs Kathleen Bevis Mrs Pamela Blunt Ms Jess Bradley Ms Kathleen Brient Ms Beverley Brown Mrs Jane Burrell & Mr Lloyd Sokvitne Ms Jill M Cassidy Dr Susan R Cherry Mrs Emma &

Mr Timothy Claridge Mrs Anita & Mr Michael Clarkson Mr Peter Cochrane & Ms Miranda Harman Mr A M Cornish AO Mr Robert & Mrs Gloria Cotgrove Mrs Diane & Mr Jonothan Davis Ms Moya T Deigan Ms Carolyn Dunnewijk Mrs Patricia & Mr Donald Edwards Mr Josh & Mrs Felicity Ey Mrs Elaine & Mr Dennis Fairfield Dr Derek & Mrs Elizabeth Findlay Mr Peter Fountain Mrs Beverley Geard Mr Don W Goff

Mrs Judy & Mr Trevor Grant Mr Garth & Mrs Brenda Haas Mrs Susan Haigh Mr Philip Hand Ms Judith Hastie Mrs Shirley & Mr Frederick Heath Ms Judy Hebblethwaite Ms Alison Hennessy Mrs Susan L Hinds Ms Di Hodel Mr B & Mrs J Hortle Mr John W Hudson Mr Andrew C Hudson Ms Shelley Hunter Ms Carol Hurst Mr Darrin Irvine Mr Gary & Mrs Susan Jacobson Mrs Wendy Jefferies

Menzies Bulletin Spring 2018

Research highlights

Researcher profile

Dr Michelle Kilpatrick Post-Doctoral Research Fellow You have been at Menzies for a little while now. How did you start here? I came to Menzies in 2011 to start my PhD. I worked on a partnership project with the Tasmanian State Government called partneringHealthy@ Work, where our research team helped to evaluate Healthy@ Work, the government’s workplace health promotion program. My work focussed on the promotion of healthy lifestyle behaviours.

What is the current focus of your research? Since completing my PhD in 2015 I have worked on another partnership project which is investigating obesity, obesity management, and the health and economic outcomes of obesity surgery. Our team has also looked at the experiences of people before and after surgery. What are some of the recent findings from your work?

We recently published a paper where we used National Health Survey data to look at who is talking to their GP about their weight. We found that most Australian adults who are overweight or obese are missing opportunities to discuss weight management with their GP, particularly if they

We need to influence policies have not developed a weight-related illness such as diabetes. About two thirds of adults in Australia are overweight or obese. Many people therefore could benefit from having guidance and support from their GP to help them achieve

Science is all around us Menzies research students and staff made a significant contribution to National Science Week events in August, helping to communicate how important and inspiring science is in everyday life. For Niamh Chapman, a PhD candidate in the Menzies Blood Pressure Research Group, National Science Week included being selected to attend Science Meets Parliament in Canberra. Niamh reflects on what National Science Weeks means to her: “I believe science is for everyone. That’s why I’m passionate about science communication and engaging with the public through campaigns such as Science Week.

Over the month of August, I attended schools, delivered a Children’s University workshop, exhibited at science events, had my first Australian radio interview, attended events with local government and even judged a junior robotics

Science is not something that should be kept in an ivory tower

or maintain a healthier weight. What is the biggest challenge in your area of research? Obesity rates have risen pretty dramatically in the last few decades. One of the biggest challenges is figuring out ways to combat this. There are many factors working against us maintaining a healthy weight. Genetic, biological, social, and environmental factors can make it harder to make the healthiest choices. As researchers and clinicians, we need to influence policies and our physical and food environments to help prevent people becoming overweight and obese, as well as helping people lose weight and sustain weight loss.

dance competition! Science Week provided the perfect platform to spread the word of science to people young and old. The most rewarding element for me is showcasing the science that is right in front of us and explaining the everyday; lifting the lid on the limitless possibilities of exploring the world around us. The school visits were a delight, seeing the spark of creativity in some of the kids and the ideas that flow out of them was infectious and has left me invigorated. In my mind, science is not something that should be kept in an ivory tower or hidden in a lab. It should be shared with people

What is the most interesting aspect of your work? I love the variety of the work that I do, in my own research as well as supervising students and contributing to other university and community research projects. It is exciting to help develop and investigate important research questions that can have a positive impact on individuals and communities. What do you enjoy doing in your spare time? In my spare time you’ll find me kicking the soccer ball with my kids, doing photography or disappearing into the garden for hours at a time to tend the veggies.

through engaging stories, to bring the wonders and excitement of discovery to life.”

Inspired: Niamh Chapman.

Menzies was a supporting partner in the popular Beaker Street@TMAG event and also ran activities at the Festival of Bright Ideas. Several PhD students from Menzies visited schools as part of the Young Tassie Scientists program.

Menzies Bulletin Spring 2018

research thanks to you

Closing in on glaucoma

Hooked on helping: Kerry Woolley and Paul Bennett, on behalf of the ‘Dribble and Shake’ fishing fundraiser, presenting the cheque to Menzies researchers Associate Professor Jo Dickinson and Professor Tracey Dickson.

Research that originated almost 25 years ago in Tasmania has helped a team of Australian researchers identify over 50 new gene markers that increase a person’s risk of developing glaucoma, the leading cause of irreversible blindness. The study, which now includes more than 134,000 people from around the world, found 101 genetic markers that influence the fluid pressure in a person’s eye, including 85 not known previously. Elevated pressure is commonly associated with increased glaucoma risk.

Ophthalmogist and researcher Professor Alex Hewitt with patient Helen McNeice.

From its beginnings as the Glaucoma Inheritance Study in Tasmania, established by Professor David Mackey at the University of Tasmania in the 1990s, the recent study is the largest genetic study of glaucoma performed to date and involved participants from throughout Australia and around the world. Professor Alex Hewitt, a senior author on the study and a clinical researcher at Menzies, said glaucoma was the leading cause of irreversible blindness in the community and was largely preventable through timely treatment.

Fishing for a cure A group of boating mates is literally fishing for a cure, having been motivated to raise money for medical research after the death of a friend from prostate cancer at the age of 49. The group of five mates, who fish from Dodges Ferry, organised “Dribble and Shake”,

a competition to land the biggest flathead. In doing so they raised $14,500 for Menzies research into prostate cancer and Parkinson’s Disease. They chose the name of the event to highlight the effects of these diseases in a way that was not all doom and gloom, and to provide a message of encouragement. One of the organisers, Paul Bennett, has Parkinson’s disease, and another, Kerry Woolley, has been diagnosed with prostate cancer.

STUDIES RECRUITING PARTICIPANTS

METHODS: This randomised controlled trial of methotrexate is seeking participants aged 40-70 with moderate to severe hand joint pain. The study aims to reduce pain and swelling and slow joint damage in people with symptomatic hand osteoarthritis and synovitis. Contact: Kathy Buttigieg on (03) 6226 6909 or Kathy. Buttigieg@utas.edu.au. CurKOA trial: A randomised trial of turmeric (Curcuma Longa) for treating symptoms and effusion-synovitis of knee osteoarthritis is seeking participants aged 40 and over who have significant knee pain and swelling on most days, are able to have a knee MRI, and have access to email and web browsing. Contact: Gudrun.Wells@utas.edu.au or (03) 6226 4369. Tasmanian Chronic Kidney Disease Study is seeking people over 18 who have severe chronic kidney disease (eGFR less than 30mls/min/1.73m2) AND who are not receiving

dialysis or a kidney transplant. Participation requires an appointment for one to two hours. Contact: Hannah. RobertTissot@utas.edu.au or (03) 6226 7761. QUARTET: An investigator initiated and conducted, multicentre, randomised double blind controlled trial to assess the effectiveness and tolerability of ultra-low-dose quadruple combination therapy (‘LDQT’) in patients with hypertension. Contact: Kirby.Donaldson@ utas.edu.au or (03) 6226-4802. The Menzies Blood Pressure Clinic is a community service offered to improve the care of people with problems related to high blood pressure. The clinic uses the latest methods dedicated to the investigation and management of high blood pressure. People referred to the clinic undergo various blood pressure tests, as well as comprehensive risk assessments. A report is then sent to the referring GP. All services are bulk-billed. Contact:

Adam Kane (03) 6226-4710 or Menzies.BPclinic@utas.edu.au. PPMS: Primary Progressive MS Study into risk factors for the onset and rate of progression of Primary Progressive MS. Contact: Alice Saul (03) 6226-4269 or ppms. study@utas.edu.au or www. menzies.utas.edu.au/PPMS AMSLS: The Australian MS Longitudinal Study to provide data of practical use for improving the lives of Australians living with MS. Contact: Kirsty Hawkes (03) 6226 4739 or AMSLS.Info@utas.edu.au, www.msra.org.au/AMSLS KARAOKE: A randomised trial of krill oil for osteoarthritis of the knee to examine use of krill oil to improve knee pain and slow down progression of knee osteoarthritis. Participants must be: aged 40 years or more; have significant knee pain and swelling most days for at least six months; able to have a knee MRI. Contact: Carole.Goff@ utas.edu.au or (03) 6226 4648.

Genetics of Eye Diseases for genetic studies in diabetic retinopathy (participants should have Type 2 Diabetes treated with medication for at least five years, or Type 1 Diabetes); keratconus (participants should have keratoconus diagnosed by an optometrist or ophthalmologist); and advanced glaucoma (participants should have any type of glaucoma with severe vision loss treated by an ophthalmologist). Contact: jacqueline.townley@ utas.edu.au or (03) 6226 4731 AirRater is recruiting people in Tasmania, Australian Capital Territory and the Northern Territory with asthma, hay fever or other lung conditions, or carers of those with these conditions. Contact: 1800 322 102 or air.rater@utas.edu.au STAREE: STAtins in Reducing Events in the Elderly investigating whether a statin can prolong good health and maintain independence among people aged 70 years and older. Contact: staree@ monash.edu or 1800 770 664

Menzies Bulletin Spring 2018

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More than flowers In Memoriam

One sentence in your Will can fund life-saving medical research. If you would like more information, please contact the Institute Advancement Manager on 03 6226 4236. Bequests save lives by funding research. Thank you.

We gratefully acknowledge gifts made from the following estates: Estate of the late N M Copeman Estate of the late Carol A Davenport Estate of the late Rosemary Agathe Heinrich Estate of the late Rex Ernest Morriss Estate of the late Elizabeth Joy Smith We gratefully acknowledge gifts made in honour of: Mrs Jean Allanby Mr Robert A Almond Mr Robert J Egan Mr James A B Finlay Mrs Wendy Gillies Dr Hugh R Jackson Mrs Kathleen R Jamieson Ms Alison J Jeffries Mr Raymond J Keogh Mr Wally Mainsbridge Mr Charles F Marten Mr Ian R Matterson Mr Vernon J Oakley Mrs Doreen M Paice Dr John D Sallis Mr Gerard A J Veldhuis Mrs Wynne Ward