January dementia current awareness by Musgrove Park Hospital Library

Library Services Musgrove Park and Somerset Partnership

Current Awareness Dementia This monthly Current Awareness Bulletin is produced by the Library, Musgrove Park Academy to provide staff with a range of dementia-related resources to support practice. It includes recently published guidelines and research articles, news and policy items.

This guide provides a selection of resources relevant to the subject area and is not intended to be a comprehensive list. All websites have been evaluated and details are correct at the time of publications. Details correct at time of going to print. Please note that resources are continuously updated. For further help or guidance, please contact a member of library staff.

This guide has been compiled by: Jess Pawley Senior Library Assistant Musgrove Park Hospital Library Service jessica.pawley@tst.nhs.uk Issue 8 January 2016

Contents Click on a section title to navigate contents Page Recent journal articles

Books

Cochrane Systematic Reviews

Guidelines

UpToDate & DynaMed

Dementia in the News

Reports, publications and resources

Topic Alerts and Updates

Twitter

Training & Networking Opportunities, Conferences, Events

Literature search service

Training and Athens

Library contact details: Library Musgrove Park Academy Musgrove Park Hospital Taunton Somerset TA1 5DA Tel: 01823 34 (2433) Fax: 01823 34 (2434) Email: library@tst.nhs.uk Blog: http://librarymph.wordpress.com @musgrovesompar

RECENT JOURNAL ARTICLES BACK TO TOP This is a list of journal articles on the topic of dementia. Some articles are available in the library or on-line via an OpenAthens password by following the full-text link. If you would like an article which is not available as full-text then please contact library staff. Please note that abstracts are not always available for all articles.

Title: Effects of a psycho-educational intervention on direct care workers' communicative behaviors with residents with dementia. Citation: Health communication, Apr 2016, vol. 31, no. 4, p. 453-459 (April 2016) Author(s): Barbosa, Ana, Marques, Alda, Sousa, Liliana, Nolan, Mike, Figueiredo, Daniela Abstract: This study assessed the effects of a person-centered care-based psycho-educational intervention on direct care workers' communicative behaviors with people with dementia living in aged-care facilities. An experimental study with a pretest-posttest control-group design was conducted in four aged-care facilities. Two experimental facilities received an 8-week psychoeducational intervention aiming to develop workers' knowledge about dementia, person-centered care competences, and tools for stress management. Control facilities received education only, with no support to deal with stress. In total, 332 morning care sessions, involving 56 direct care workers (female, mean age 44.72 ± 9.02 years), were video-recorded before and 2 weeks after the intervention. The frequency and duration of a list of verbal and nonverbal communicative behaviors were analyzed. Within the experimental group there was a positive change from pre- to posttest on the frequency of all workers' communicative behaviors. Significant treatment effects in favor of the experimental group were obtained for the frequency of inform (p < .01, η(2)partial = 0.09) and laugh (p < .01, η(2)partial = 0.18). Differences between groups emerged mainly in nonverbal communicative behaviors. The findings suggest that a person-centered care-based psycho-educational intervention can positively affect direct care workers' communicative behaviors with residents with dementia. Further research is required to determine the extent of the benefits of this approach.

Title: Mild cognitive impairment in Parkinson's disease: Diagnosis and progression to dementia. Citation: Journal of clinical and experimental neuropsychology, Feb 2016, vol. 38, no. 1, p. 40-50 (February 2016) Author(s): Galtier, Iván, Nieto, Antonieta, Lorenzo, Jesús N, Barroso, José Abstract: Mild cognitive impairment is common in nondemented Parkinson disease patients (PDMCI) and is considered as a risk factor for dementia (PDD). Recently, the Movement Disorder Society (MDS) published guidelines for PD-MCI, although the studies available are still limited. The aim of this work was to characterize PD-MCI and its progression to dementia. Moreover, the study variables could be considered as predictors for the progression of cognitive impairment. The study included 43 patients with idiopathic PD (mean age = 59.19 years, SD = 9.64) and 20 healthy and neurologically normal controls (mean age = 60.85 years, SD = 12.26). The criteria proposed by the MDS Task Force

were applied for the PD-MCI diagnosis. Follow-up assessments were conducted within six to eight years after the diagnosis of PD-MCI. The results showed that 60.5% of the patients were diagnosed with PD-MCI when a comprehensive assessment was performed (MDS criteria Level 2), while 23.3% of the patients met MCI criteria when a brief assessment was used (MDS criteria Level 1). Multiple domain impairment was the most frequent impairment (96.2%). A total of 42.3% of PD-MCI patients had dementia in the follow-up study. Logistic regression showed that the Hoehn and Yahr stage and education significantly contributed to the prediction of PD-MCI. Moreover, the Hoehn and Yahr stage and memory domain significantly contributed to the prediction of dementia. The results of the study: (a) provide relevant data about the process of validation of the MDS PD-MCI criteria, (b) reinforce the hypothesis that PD-MCI is more frequent than previous studies showed without applying MDS criteria, and (c) confirm that PD-MCI is a risk factor for the onset of dementia. Finally, the study shows that neurological impairment, educational level and memory impairment were predictors for the progression of cognitive impairment.

Title: Alzheimer's Disease: Prototype of Cognitive Deterioration, Valuable Lessons to Understand Human Cognition. Citation: Neurologic clinics, Feb 2016, vol. 34, no. 1, p. 69-131 (February 2016) Author(s): Noroozian, Maryam Abstract: It is important for neurologists to become more familiar with neuropsychological evaluation for Alzheimer disease. The growth of this method in research, as an available, inexpensive, and noninvasive diagnostic approach, which can be administered even by non-specialist-trained examiners, makes this knowledge more necessary than ever. Such knowledge has a basic role in planning national programs in primary health care systems for prevention and early detection of Alzheimer disease. This is more crucial in developing countries, which have higher rates of dementia prevalence along with cardiovascular risk factors, lack of public knowledge about dementia, and limited social support. In addition compared to the neurological hard signs which are tangible and measurable, the concept of cognition seems to be more difficult for the neurologists to evaluate and for the students to understand. Dementia in general and Alzheimer's disease as the prototype of cognitive disorders specifically, play an important role to explore all domains of human cognition through its symptomatology and neuropsychological deficits. Copyright © 2016 Elsevier Inc. All rights reserved.

Title: Frontotemporal Dementia. Citation: Neurologic clinics, Feb 2016, vol. 34, no. 1, p. 171-181 (February 2016) Author(s): Kelley, Roger E, El-Khoury, Ramy Abstract: Frontotemporal dementia (FTD) is a not-uncommon explanation for progressive cognitive deficit in patients who often have a genetic susceptibility for such a neurodegenerative process. However, FTD does not seem to identify one particular pathogenetic mechanism but rather a spectrum of pathologies with particular predilection for the frontal and temporal lobes of the brain. There have been various subcategorizations of this form of dementia that have a tendency to be of earlier onset than typical Alzheimer disease and heralded by behavioral or communication manifestations. There is a behavioral variant and a language variant, referred to as primary progressive aphasia. Copyright © 2016 Elsevier Inc. All rights reserved.

Title: Therapeutic strategies for Alzheimer's disease in clinical trials. Citation: Pharmacological reports : PR, Feb 2016, vol. 68, no. 1, p. 127-138, 1734-1140 (February 2016) Author(s): Godyń, Justyna, Jończyk, Jakub, Panek, Dawid, Malawska, Barbara

Abstract: Alzheimer's disease (AD) is considered to be the most common cause of dementia and is an incurable, progressive neurodegenerative disorder. Current treatment of the disease, essentially symptomatic, is based on three cholinesterase inhibitors and memantine, affecting the glutamatergic system. Since 2003, no new drugs have been approved for treatment of AD. This article presents current directions in the search for novel, potentially effective agents for the treatment of AD, as well as selected promising treatment strategies. These include agents acting upon the beta-amyloid, such as vaccines, antibodies and inhibitors or modulators of γ- and β-secretase; agents directed against the tau protein as well as compounds acting as antagonists of neurotransmitter systems (serotoninergic 5-HT6 and histaminergic H3). Ongoing clinical trials with Aβ antibodies (solanezumab, gantenerumab, crenezumab) seem to be promising, while vaccines against the tau protein (AADvac1 and ACI-35) are now in early-stage trials. Interesting results have also been achieved in trials involving small molecules such as inhibitors of β-secretase (MK-8931, E2609), a combination of 5HT6 antagonist (idalopirdine) with donepezil, inhibition of advanced glycation end product receptors by azeliragon or modulation of the acetylcholine response of α-7 nicotinic acetylcholine receptors by encenicline. Development of new effective drugs acting upon the central nervous system is usually a difficult and time-consuming process, and in the case of AD to-date clinical trials have had a very high failure rate. Most phase II clinical trials ending with a positive outcome do not succeed in phase III, often due to serious adverse effects or lack of therapeutic efficacy. Copyright © 2015 Institute of Pharmacology, Polish Academy of Sciences. Published by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

Title: Palliative care and dementia - A time and place? Citation: Maturitas, February 2016, vol./is. 84/(5-10), 0378-5122;1873-4111 (01 Feb 2016) Author(s): Kydd A., Sharp B. Abstract: The current focus in dementia care places emphasis on the potential of people to live well with the condition. Given the historical tendency to neglect the full rights and citizenship of people with dementia, such an emphasis gives hope and optimism that there is life after diagnosis. This paper seeks to explore the potential compromise of effective preparation for the complexities of advanced illness that may be presented by this consistently up-beat message. Dementia is a life limiting condition, currently without cure. Therefore, the appropriateness of palliative care may seem obvious. Yet, until relatively recently, palliative care was seen as an adjunct to oncology in the minds of professionals and public alike. However, there is a growing recognition that specialist palliative care has much to offer people with a range of long term conditions, including people with dementia. So, whilst 'living well' is an important message - especially following diagnosis - planning for advanced dementia and dying well is equally important. The aim of this paper is to highlight policy on the living well and the palliative care approach for people with dementia. A word limited narrative literature review was conducted to explore how policies have or have not informed the literature on both messages. The findings emphasise the need for a continuum approach to dementia care, with discussion on when, where, and how can palliative care be delivered for people with dementia.

Title: The basis, ethics and provision of palliative care for dementia: A review Citation: Maturitas, January 2016, vol./is. 83/(3-8), 0378-5122;1873-4111 (01 Jan 2016) Author(s): Mahin-Babaei F., Hilal J., Hughes J.C. Abstract: Interest in palliative care for people with dementia has been around for over two decades. There are clinical and ethical challenges and practical problems around the implementation of good quality palliative care in dementia. This narrative review of the literature focuses on the rationale or basis for services, some of the ethical issues that arise (particularly to do with artificial nutrition and hydration) and on the provision and implementation of services. We focus on the most recent literature. The rationale for palliative care for people with dementia is based on research and on an

identified need for better clinical care. But the research largely demonstrates a paucity of good quality evidence, albeit particular interventions (and non-interventions) can be justified in certain circumstances. Numerous specific clinical challenges in end-of-life care for people with dementia are ethical in nature. We focus on literature around artificial nutrition and hydration and conclude that good communication, attention to the evidence and keeping the well-being of the person with dementia firmly in mind will guide ethical decision-making. Numerous challenges surround the provision of palliative care for people with dementia. Palliative care in dementia has been given definition, but can still be contested. Different professionals provide services in different locations. More research and education are required. No single service can provide palliative care for people with dementia.

Title: The effect of physical activity on cognitive function in patients with dementia: A metaanalysis of randomized control trials. Citation: Ageing research reviews, Jan 2016, vol. 25, p. 13-23 (January 2016) Author(s): Groot, C, Hooghiemstra, A M, Raijmakers, P G H M, van Berckel, B N M, Scheltens, P, Scherder, E J A, van der Flier, W M, Ossenkoppele, R Abstract: Non-pharmacological therapies, such as physical activity interventions, are an appealing alternative or add-on to current pharmacological treatment of cognitive symptoms in patients with dementia. In this meta-analysis, we investigated the effect of physical activity interventions on cognitive function in dementia patients, by synthesizing data from 802 patients included in 18 randomized control trials that applied a physical activity intervention with cognitive function as an outcome measure. Post-intervention standardized mean difference (SMD) scores were computed for each study, and combined into pooled effect sizes using random effects meta-analysis. The primary analysis yielded a positive overall effect of physical activity interventions on cognitive function (SMD[95% confidence interval]=0.42[0.23;0.62], p<.01). Secondary analyses revealed that physical activity interventions were equally beneficial in patients with Alzheimer's disease (AD, SMD=0.38[0.09;0.66], p<.01) and in patients with AD or a non-AD dementia diagnosis (SMD=0.47[0.14;0.80], p<.01). Combined (i.e. aerobic and non-aerobic) exercise interventions (SMD=0.59[0.32;0.86], p<.01) and aerobic-only exercise interventions (SMD=0.41[0.05;0.76], p<.05) had a positive effect on cognition, while this association was absent for non-aerobic exercise interventions (SMD=-0.10[-0.38;0.19], p=.51). Finally, we found that interventions offered at both high frequency (SMD=0.33[0.03;0.63], p<.05) and at low frequency (SMD=0.64[0.39;0.89], p<.01) had a positive effect on cognitive function. This meta-analysis suggests that physical activity interventions positively influence cognitive function in patients with dementia. This beneficial effect was independent of the clinical diagnosis and the frequency of the intervention, and was driven by interventions that included aerobic exercise. Copyright ÂŠ 2015 Elsevier B.V. All rights reserved.

Title: Is the Mediterranean diet a feasible approach to preserving cognitive function and reducing risk of dementia for older adults in Western countries? New insights and future directions. Citation: Ageing research reviews, Jan 2016, vol. 25, p. 85-101 (January 2016) Author(s): Knight, Alissa, Bryan, Janet, Murphy, Karen Abstract: The rise in the ageing population has resulted in increased incident rates of cognitive impairment and dementia. The subsequent financial and societal burden placed on an already strained public health care system is of increasing concern. Evidence from recent studies has revealed modification of lifestyle and dietary behaviours is, at present, the best means of prevention. Some of the most important findings, in relation to the Mediterranean diet (MedDiet) and the contemporary Western diet, and potential molecular mechanisms underlying the effects of these two diets on age-related cognitive function, are discussed in this review. A major aim of this review was to

discuss whether or not a MedDiet intervention would be a feasible preventative approach against cognitive decline for older adults living in Western countries. Critical appraisal of the literature does somewhat support this idea. Demonstrated evidence highlights the MedDiet as a potential strategy to reduce cognitive decline in older age, and suggests the Western diet may play a role in the aetiology of cognitive decline. However, strong intrinsic Western socio-cultural values, traditions and norms may impede on the feasibility of this notion. Copyright ÂŠ 2015 Elsevier B.V. All rights reserved.

Title: Activity involvement and quality of life of people at different stages of dementia in long term care facilities. Citation: Aging & Mental Health, 2016, vol./is. 20/1(100-109), 13607863

Title: Experts: Number of People With Dementia Worldwide Expected to Rise. Citation: American Journal of Public Health, 2016, vol./is. 106/1(9-), 00900036 Full Text: Available from EBSCOhost in American Journal of Public Health Available from ProQuest in American Journal of Public Health Available from EBSCOhost in American Journal of Public Health

Title: Instrumental variable approaches to identifying the causal effect of educational attainment on dementia risk. Citation: Annals of Epidemiology, 2016, vol./is. 26/1(71-71), 10472797 Abstract: Purpose: Education is an established correlate of cognitive status in older adulthood, but whether expanding educational opportunities would improve cognitive functioning remains unclear given limitations of prior studies for causal inference. Therefore, we conducted instrumental variable (IV) analyses of the association between education and dementia risk, using for the first time in this area, genetic variants as instruments as well as state-level school policies.Methods: IV analyses in the Health and Retirement Study cohort (1998-2010) used two sets of instruments: (1) a genetic risk score constructed from three single-nucleotide polymorphisms (SNPs; n = 7981); and (2) compulsory schooling laws (CSLs) and state school characteristics (term length, student teacher ratios, and expenditures; n = 10,955).Results: Using the genetic risk score as an IV, there was a 1.1% reduction in dementia risk per year of schooling (95% confidence interval, -2.4 to 0.02). Leveraging compulsory schooling laws and state school characteristics as IVs, there was a substantially larger protective effect (-9.5%; 95% confidence interval, -14.8 to -4.2). Analyses evaluating the plausibility of the IV assumptions indicated estimates derived from analyses relying on CSLs provide the best estimates of the causal effect of education.Conclusions: IV analyses suggest education is protective against risk of dementia in older adulthood.

Title: Dementia: caring for the carer is just as important. Citation: British Journal of Community Nursing, 2016, vol./is. 21/1(5-), 14624753 Full Text: Available from EBSCOhost in British Journal of Community Nursing

Title: Dementia beyond 2025: Knowledge and uncertainties. Citation: Dementia (14713012), 2016, vol./is. 15/1(6-21), 14713012

Title: What is the current state of care for older people with dementia in general hospitals? A literature review. Citation: Dementia (14713012), 2016, vol./is. 15/1(106-124), 14713012

Title: Community palliative care use by dementia sufferers may reduce emergency department use at end of life. Citation: Evidence Based Nursing, 2016, vol./is. 19/1(29-29), 13676539 Full Text: Available from Highwire Press in Evidence-Based Nursing

Title: Survival after Suspected Urinary Tract Infection in Individuals with Advanced Dementia Citation: Journal of the American Geriatrics Society, December 2015, vol./is. 63/12(2472-2477), 0002-8614;1532-5415 (01 Dec 2015) Author(s): Dufour A.B., Shaffer M.L., D'Agata E.M.C., Habtemariam D., Mitchell S.L. Abstract: Objectives To determine whether antimicrobial treatment for suspected urinary tract infections (UTIs) improves survival in nursing home residents with advanced dementia. Design Prospective cohort study. Setting Thirty-five nursing homes in Boston, Massachusetts. Participants Nursing home residents who experienced at least one suspected UTI over a 12-month period (N = 110); mean participant age 86.4 +/- 6.2, 84% female. Measurements Analyses were at the level of the UTI episode. Antimicrobial treatment for each suspected UTI was categorized as none, oral, intramuscular, or intravenous or hospitalization. Survival was calculated from the date of suspected UTI episode until death or last known follow-up date. Covariates included resident and episode characteristics. Cox proportional hazards regression was used to examine the association between treatment group and risk of death after adjusting for covariates. Results Residents experienced 196 suspected UTIs over the follow-up period; 33% (n = 36) died during follow-up. There was no antimicrobial use for 25.0% of the 196 suspected UTIs, oral antimicrobial use in 59.7%; intramuscular antimicrobial use in 9.2%, and intravenous antimicrobial use or hospital transfer in 6.1%. After multivariable adjustment, antimicrobial treatment was not significantly associated with mortality (oral, adjusted hazard ratio for death (AHR) = 1.09, 95% confidence interval (CI) = 0.43-2.75; intramuscular, AHR = 0.66, 95% CI = 0.08-5.66; intravenous or hospitalization, AHR = 1.83, 95% CI = 0.44-7.60). Conclusion Although the majority of suspected UTIs that nursing home residents with advanced dementia experienced were treated with antimicrobials, treatment was not associated with survival.

BOOKS BACK TO TOP If you are unable to find a book, or require a book that is not on this list, please ask library staff who will be able to locate the book for you using interlibrary loan. Please note that some books detailed below may not be available in your local library and would need to be ordered for you. Nursing and Health- Dementia Care Survival Guide Dawn Brooker et al 2013

The Common Sense Guide to Dementia for Clinicians and Caregivers Anne M. Upton 2013

From the back of the book:

Ideal for quick reference, this pocket-sized guide puts all the crucial information on caring for patients with dementia at your fingertips. All you need to know on:

This ground-breaking title unifies the perspectives of neurology and psychiatry to meet a variety of caregiver needs. It spotlights many real-world concerns not typically covered in standard textbooks, while simultaneously presenting a more detailed medical perspective than typical caregiver manuals. This handy title offers expert guidance for the clinical management of dementia and compassionate support of patients and families. The Common Sense Guide espouses general principles of dementia care that apply across the stages and spectrum of this illness, including non-Alzheimer's types of dementia, in addition to Alzheimer's disease.. The authors place an emphasis on caring for the caregiver as well as the patient. Essential topics include how to find the right clinician, make the most of a doctor's visit, and avert a crisis - or manage one that can't be avoided. Sometimes difficult considerations, such as driving, financial management, legal matters, long-term placement, and end-of-life care, are faced head-on. Tried, true, and time-saving tips are explained in terms of what works and what doesn't - with regard to clinical evaluation, medications, behavioral measures, and alternate therapies.

    

Person-centered dementia care Communication and managing behaviour Pain assessment Nutrition and medication Advanced care plans

Taunton and SomPar NHS staff - Have you visited the EBL eBook catalogue? Follow the links below and login via OpenAthens to read online books free for 5-10 minutes each day, send requests for eBook loans or purchase suggestions Taunton & Somerset eBook catalogue Somerset Partnership eBook catalogue About OpenAthens

COCHRANE SYSTEMATIC REVIEWS BACK TO TOP

Reviews from January 2016 Statins for the prevention of dementia

GUIDELINES BACK TO TOP NICE Guidelines NG22: Older people with social care needs and multiple long-term conditions- November 2015 NG16: Disability, dementia and frailty in later life- mid-life approaches to prevention- October 2015

UPTODATE & DYNAMED BACK TO TOP Whatâ&#x20AC;&#x2122;s new from our clinical decision-making tools on the topic of dementia. UpToDate (Access for Musgrove Park Staff only) DynaMed Please contact library staff for details on how to access these resources; you will need an Athens password.

DEMENTIA IN THE NEWS BACK TO TOP BBC News Dementia loved ones ‘benefit from visits’ Blocking brain inflammation ‘halts Alzheimer’s disease’

REPORTS, PUBLICATIONS AND RESOURCES BACK TO TOP NICE Pathway on Dementia NICE Pathway on Dementia, Disability and Frailty in Later Life: Mid-Life Approaches to Delay or Prevent Onset overview SCIE (Social Care Institute for Excellence) Dementia Gateway th

10 UK Dementia Congress 2015- slides and presentations from this year’s conference Improving Dementia Education and Awareness (IDEA)- Online resource created by the University of Nottingham, listing online courses, news, events and resources. Age UK- resource and information page on dementia. DEEP- the dementia engagement and empowerment project

Peer support for people with dementia: resource pack and social return on investment The Health Innovation Network has worked with AGE UK, The Alzheimer’s Society, Innovations in Dementia, Mental Health Foundation and community groups across South London to produce a Resource Pack to promote the importance of peer support opportunities for people with dementia. It brings together in one place evidenced based resources to help community groups and funders set up and run peer support groups, as well as guidance on how to make older people groups more dementia friendly. Dementia friendly communities: supported learning and outreach with the deaf community This report aims to inform the development of policy and practice in relation to dementia awareness and information models in the Deaf community and with people with hearing loss. These approaches challenge misconceptions and provide signposting for appropriate information and support. The report considers and provides next steps on best practice models based on a pilot project with Alzheimer’s Society and BDA.

James’ story: ‘How caring for my mother led me to Unforgettable’ Unforgettable.org is the world’s best marketplace of products and services for dementia and memory loss. We are making it easier for carers to discover products that really help and for product and service providers to reach carers at home. We have products you didn’t even know existed that can make life easier every day, helpful articles and expert advice, a friendly forum community and all the latest dementia and memory loss news. Dementia in the family: impact on carers This report from Alzheimer's Research UK highlights the realities of daily life for carers who are looking after their loved ones and reveal how dementia changes family relationships, leaving people feeling socially isolated, and affects both the health and finances of family carers. The findings underline the importance of research to provide new treatments capable of reducing care needs for people with the condition. Mental Health Dementia and Neurology Intelligence Network The National Mental Health, Dementia and Neurology Intelligence Network (NMHDNIN) is hosted by Public Health England (PHE) and is jointly sponsored with NHS England. We work in partnership with stakeholders from public health, health and social care and local authorities, as well as leaders from the voluntary sector and organisations which represent people who use mental health, dementia and neurology services. Establishing NMHDNIN is a priority in delivering closing the gap and builds on work previously undertaken by Public Health Observatories and NHS England’s predecessor organisations.

Study shows beneficial effects of blocking brain inflammation in an experimental model of Alzheimer’s A study, published in the journal Brain, has found that blocking a receptor in the brain responsible for regulating immune cells could protect against the memory and behaviour changes seen in the progression of Alzheimer’s disease. The research was jointly funded by the MRC and Alzheimer’s Research UK. Donepezil, nursing home placement and Alzheimer’s disease The DOMINO-AD trial (Jones et al, 2009) was a pragmatic multi-centre randomised trial with the primary aim of identifying the best treatment options for those living at home with moderate to severe Alzheimer’s Disease dementia (AD). Currently the most commonly prescribed cholinesterase inhibitor Donepezil (Aricept) is only licensed for treating those with mild to moderate AD. The evidence suggests its effectiveness is very slight in terms of cognitive and functional outcomes for those with more severe symptoms, so it is often discontinued as the disease progresses. Memantine is a glutamate agonist and works differently. It is widely prescribed as an alternative to cholinesterase inhibitors, and for more severe symptoms.

TOPIC ALERTS AND UPDATES BACK TO TOP ABSTRACTS AVAILABLE VIA LINKS BELOW- FOR FULL-TEXT PLEASE ASK LIBRARY STAFF

NHS Evidence Specialist nursing and community support for the carers of people with dementia living at home: an evidence synthesis Health and Social Care in the Community (2016) 24(1), 48–67 FREE FULL TEXT Understanding dementia: effective information access from the Deaf community’s perspective Health and Social Care in the Community (2016) 24(1), 39–47 FREE FULL TEXT

Potentially inappropriate anticholinergic medication use in older adults with dementia J Am Pharm Assoc 2015;55:603-612. Development of interventions for the secondary prevention of Alzheimer's dementia: the European Prevention of Alzheimer's Dementia (EPAD) project Lancet Psychiatry Published Online: 09 December 2015

Elsevier Practice Updates Meta-analysis of modifiable risk factors for Alzheimer's disease J Neurol Neurosurg Psychiatry2015;86:1299-1306 FREE FULL TEXT AVAILABLE WITH ATHENS LOGIN Alcohol consumption and mortality in patients with mild Alzheimer’s disease: a prospective cohort study BMJ Open 2015;5:e007851. FREE FULL TEXT Combined Plasma and Cerebrospinal Fluid Signature for the Prediction of Midterm Progression From Mild Cognitive Impairment to Alzheimer Disease JAMA Neurol. Published online December 14, 2015.

Medscape Topic Alerts Androgen deprivation therapy and future Alzheimer’s disease risk Journal of Clinical Oncology, Published online before print December 7, 2015 Influence of perceived stress on incident amnestic mild cognitive impairment: results from the Einstein aging study Alzheimer Dis Assoc Disord. 2015 Dec 10. [Epub ahead of print] Seven-Tesla MRI and neuroimaging biomarkers for Alzheimer’s disease Neurosurgical Focus Nov 2015 / Vol. 39 / No. 5 / Page E4 Common variants in ABCA7 and MS4A6A are associated with cortical and hippocampal atrophy Neurobiology of Aging, March 2016 Volume 39, Pages 82–89

TRIP Database Marital status and risk of dementia: a nationwide population-based prospective study from Sweden BMJ Open2016;6:e008565 FREE FULL TEXT Discharge Destination of Dementia Patients Who Undergo Intermediate Care at a Facility J Am Med Dir Assoc. 2016 Jan 1;17(1):92.e1-7 Pathological α-synuclein distribution in subjects with coincident Alzheimer’s and Lewy body pathology Acta Neuropathologica pp 1-17 First online: 31 December 2015 FREE FULL TEXT A Systematic Review of Metacognitive Differences Between Alzheimer's Disease and Frontotemporal Dementia. Am J Alzheimers Dis Other Demen. 2015 Dec 24. [Epub ahead of print]

Medline Plus Clinical and Demographic Factors Associated with the Cognitive and Emotional Efficacy of Regular Musical Activities in Dementia Journal of Alzheimer's Disease, vol. 49, no. 3, pp. 767-781, 2015 Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia Diabetes Care December 17, 2015

TWITTER BACK TO TOP The latest from popular Twitter pages dedicated to dementia: Dementia UK @DementiaUK Alzheimer’s Society @alzheimerssoc Dementia Today @DementiaToday Dementia Friends @DementiaFriends

TRAINING & NETWORKING OPPORTUNITIES, CONFERENCES, EVENTS BACK TO TOP

Alzheimer’s Society Training and resources Dementia training for care providers Health Education England Dementia awareness training RCN Ongoing work at the RCN on dementia care

Alzheimer’s Research UK Research Conference- 8 March 2016, Manchester th

Dementia 2020- Transforming Care, Support and Research- 12 April 2016 st

31 International Conference of Alzheimer’s Disease International- 21 -24 April 2016, Budapest th

26 Alzheimer Europe Conference- 31 October-2

November 2016, Copenhagen

LITERATURE SEARCH SERVICE BACK TO TOP Looking for the latest evidence-based research but havenâ&#x20AC;&#x2122;t got time to trawl the databases? Do you need a literature search carried out? Do you need to find evidence to support an improvement? Do you want to know how something has been done elsewhere and whether it worked?

Library staff provide a literature search service for busy clinicians who are pressed for time.

To request a search please complete and return the appropriate form, providing as much information as possible. Alternatively if you would like an assisted search training session, where we will sit down with you and go through the steps of a literature search, then please contact the library. Musgrove staff click here to access literature search form Somerset Partnership staff click here to access literature search form

TRAINING AND ATHENS BACK TO TOP Most electronic resources are available via an Athens password. You can register for this via the Library intranet page, or from home at www.swice.nhs.uk and following the link for Athens selfregistration. Please note that registering from home will take longer as it will need to be verified that you are NHS staff/student on placement. The library offers training on how to access and use Athens resources, as well as an introductory course on critical appraisal. You can book a course through the Learning and Development intranet page, or by contacting the library directly.