RADIOLOGY

Department Report

The Department of Pediatric Radiology at Nationwide Children’s Hospital is one of the nation’s premier imaging programs for children, with subspecialty expertise in abdominal, cardiac, chest, fetal/neonatal, interventional, musculoskeletal, neuroimaging and nuclear imaging. We provide expert care in imageguided diagnosis and therapy. Our mission is to improve children’s lives through innovative imaging. The major philosophical consideration that drives our mission is that children are not small adults. Technology must be adapted to meet the needs of pediatric patients to create imaging biomarkers specific for pediatric disease. Our vision of the reinvented imaging department, the Children’s Imaging Biomarker Alliance (CIBA), was born with the following goals: • Develop and validate imaging biomarkers specific to pediatric disease • Determine quality, safety and cost-effectiveness of validated imaging biomarkers for discrete patient care pathways • Integrate imaging biomarkers across the basic/translational /clinical spectrum • Integrate pediatric research across departments, imaging modalities and populations The imaging infrastructure is located in the Pediatric Advanced Imaging Resource (PAIR), which brings together strategic partnerships and shared cutting-edge resources with optimized distribution of imaging technology and skilled personnel, an integrated model of imaging informatics, a robust quality and safety infrastructure and an advanced image-processing program which includes 3D modeling and 3D printing for personalized treatment planning and creation of patient-specific devices.

FACULTY

Rajesh Krishnamurthy, MD

Radiologist-in-Chief

Brent H. Adler, MD David Gregory Bates, MD Adam Bobbey, MD Section Chief, Nuclear Medicine and Molecular Imaging Leah Braswell, MD Associate Section Chief, Interventional Imaging Ellen Chung, MD Associate Radiologist-in-Chief Eric Diaz, MD Stephen Druhan, MD Elizabeth Hingsbergen, MD Mai-Lan Ho, MD Mark Hogan, MD Jeremy Jones, MD Section Chief, Neuroradiology Imaging Anna Lillis, MD Lisa Martin, MD Aaron McAllister, MD Kathryn Milks, MD James Murakami, MD Becky Murray, MD Julie O’Donovan, MD Andrew Rabe, DO Mitch Rees, MD Diana Rodriguez, MD Lynne Ruess, MD

Jerome Rusin, MD Summit Shah, MD Sally Smith, DO Benjamin Thompson, DO Patrick Warren, MD Section Chief, Interventional Imaging Cody Young, DO Nicholas Zumberge, MD

Radiology has had several clinical advancements over the past year. Most notably, we have grown subspecialized programs to include:

• Cardiac Imaging: especially neonatal/infant cardiac CT, new blood pool contrast program and myocardial stress perfusion program

• Musculoskeletal Imaging: with a new Ultrasound contrast program and joint injections in collaboration with Rheumatology

• Oncologic Imaging: utilizing Tumor Metrics to quantify tumor mass and novel targeted antibody treatment

• Neuroimaging: with the utilization of Emergent Stroke Programs

• Vascular Anomalies: creating new lymphatic channel imaging and intervention programs

We successfully organized and hosted a hands-on workshop and the largest international meeting on pediatric cardiovascular magnetic resonance in October 2019 at Nationwide Children’s, partnered with 3D Imaging for Interventional Catheterization interventional cardiology group. Through a unique collaboration with the World Federation of Pediatric Imaging (WFPI), we furthered the education and training of radiologists in Argentina, Philippines, Nigeria and India. We also welcomed our first fellow in Pediatric Cardiac Imaging.

Finally, we have several advancements in research. Our research team is now led by Mai-Lan Ho, MD. Our Interventional Radiology team is administering targeted gene delivery to support gene therapy research. We have been a key imaging partner for the tissue engineering group. We are the grant award recipient of the American College of Radiology’s (ACR) Innovation Fund for the creation of “I-ROAR: Imaging Registry for Orphan And Rare Disease.” Rajesh Krishnamurthy, MD, was elected to the board of the Society of Pediatric Radiology in 2020, and is the current chair of the ACR Pediatric Imaging Research Committee.

SELECTED PUBLICATIONS

Begley KA, Braswell LE, Noritz GH, Murakami JW. Salivary gland ablation: introducing an interventional radiology treatment alternative in the management of sialorrhea. Pediatric Radiology. 2020 May;50(6):869-876.

Hu HH, Branca RT, Hernando D, Karampinos DC, Machann J, McKenzie CA, Wu HH, Yokoo T, Velan SS. Magnetic resonance imaging of obesity and metabolic disorders: Summary from the 2019 ISMRM Workshop. Magnetic Resonance in Medicine. 2020;83(5):1565-1576.

Mendell JR, Sahenk Z, Lehman K, Nease C, Lowes LP, Miller NF, Iammarino MA, Alfano LN, Nicholl A, Al-Zaidy S, Lewis S, Church K, Shell R, Cripe LH, Potter RA, Griffin DA, Pozsgai E, Dugar A, Hogan M, Rodino-Klapac LR. Assessment of Systemic Delivery of rAAVrh74.MHCK7.micro-dystrophin in Children With Duchenne Muscular Dystrophy: A Nonrandomized Controlled Trial. JAMA Neurol. 2020 Jun 15:e201484. [Epub ahead of print].

Molossi S, Agrawal H, Mery CM, Krishnamurthy R, Masand P, Sexson Tejtel SK, Noel CV, Qureshi AM, Jadhav SP, McKenzie ED, Fraser CD Jr. Outcomes in Anomalous Aortic Origin of a Coronary Artery Following a Prospective Standardized Approach. Circulation: Cardiovascular Interventions. 2020;13(2):e008445. [Epub ahead of print].

Schooler GR, Squires JH, Alazraki A, Chavhan GB, Chernyak V, Davis JT, Khanna G, Krishnamurthy R, Lungren MP, Masand PM, Podberesky DJ, Sirlin CB, Towbin AJ. Pediatric Hepatoblastoma, Hepatocellular Carcinoma, and Other Hepatic Neoplasms: Consensus Imaging Recommendations from American College of Radiology Pediatric Liver Reporting and Data System (LI-RADS) Working Group. Radiology. 2020;296(3):493-497.

2019 – 2020 NATIONWIDE CHILDREN’S FELLOWSHIP PROGRAM

PEDIATRIC RADIOLOGY

Nathan Fagan, MD (Interventional Radiology Fellow) Eric Morgan, MD (Pediatric Cardiovascular Imaging Fellow)