ND P&B Magazine Issue 1 Nov 15

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ISSUE 1

November 1, 2015

NDP&B The MAGAZINE of ND Pharma & Biotech Co.

BUSINESS INTELLIGENCE

Innovation at a Glance ND PHARMA & BIOTECH CO. LTD

R+D+i at your service

OUR COMPROMISE WITH EXCELLENCE

ND Pharma & Biotech



WELCOME ANOTHER STEP TO THE FUTURE

J.P. Rutherford Editor-in-chief

Welcome to the inaugural edition of the ND Pharma & Biotech Co. Magazine, a publication which is born with the aim of taking in-depth knowledge and look to the activities of our company and the future of this exciting reality that we live daily in our effort to give excellence in professionalism and service to our customers. From the very beginning we want to express our gratitude for all those people and clients that every day are letting us to reach more and more higher goals, especially those that deposit their trust and confidence in our work, dedication and interest. Each day here is a challenge to become more efficient, sustainable, competitive and dedicated. Each day is a challenge into the race of being adaptable to the opportunities presented by rapid developments in science and technology as the industry is undergoing some of the most dramatic changes seen in history. This edition and issue is the first we print it out, so a brief explanation of who we are and what the company is appeared as a necessity. So the brief presentation of our services, development capacities, research and innovation effort, investment policies and the unavoidable references to our history, were taken as an obligation by all the editorial board that I preside. We are a biopharmaceutical and biotechnological company, with a solid scientific medical and biochemical foundation, so our cover and number should be dedicated to the chemistry, that is at the end of the day, the substrate and the environment where all living things exist. From the furniture we use, the clothes we wear to the foods we eat or the medications we need in some periods of our lives, chemistry is all around, so we will accept that chemistry and biochemistry are forming an integral part of our lives. That science is part of our reason to exist, the foundation of every development and the light that shines after each development we made. So this publication should serve as a voice to this light in contact with our esteemed public, clients, friends, collaborators, customers and the general public. Sometimes, the labor of a company like ND Pharma & Biotech may be relegated to a second stage as we do not sell or produce (barely) finished product to the final consumer. But our importance is capital, when each person can, without knowing it effectively, are consuming our products within foods or medications they take, or benefiting from the food safety and health impact that some developments we created, are providing to them in different applications. This is the way we want to participate within the improvement of our society and well being, just making life better, or in other words, making YOUR life better. Hope you enjoy this journey as much as we do.

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NDP&B MAGAZINE As our company grows we are committed with the excellence in the fields we operate. Information also. Editor in Chief James P. Rutherford

Headquartered in the U.K., we have operations in North and Latin America, Europe and Asia. We continue to add to our existing portfolio of products through our internal discovery and clinical development programs and through a product acquisition and in- licensing strategy. During our short existence we have launched a number of products, technologies and brands that are revolutionizing certain specific industry processes and fields from health to nutrition or crop protection.

Design NDP&B Publications Service, Unit 3, London,, England, UK Contributors ND P&B Editorial Board Communications Office Marketing Office ND P&B Advertising & Marketing Enquiries marketing@ndpharmabiotech.com President of The Board Jess P. Harford CEO David M. Hwang Secretary of The Board

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OUR REASON TO EXIST

We are so proud of our existence as a company. From our founders a clear vision and mission subsists within the conscience: to make life better.

Ethel P. Hawkes ND P&B MAGAZINE is property of The ND Pharma & Biotech Company Limited and edited by the ND Pharma & Biotech Publications Service. ND Pharma & Biotech company can not held responsible for any inaccuracy that may occur, individual products and/or services advertised or late entries. Contents within this publication are informative only, so no part or the total of this publication shall be taken as offer, invitation to treat or any other form of business, Any operation or business with the company should be construed under specific agreements. No part or total of this publication or its contents should be taken as guarantee or results of any of products depicted within. Results may vary. Buyers and producers are sole responsible for the final use of products. Not all products may be available in all territories and countries despite the fact that this publication may reach it. (C) 2015 ND Pharma & Biotech Co. Reproduction forbidden. No part of this publication may be reproduced or scanned without prior written consent of the publishers. ND Pharma & Biotech is creating new and better products every day to let our customers to compete within the most demanding and exigent markets. THE ND PHARMA & BIOTECH COMPANY LIMITED

ND P&B LEADED BY A FAMILY OF ENTREPRENEURS. FINANCIALLY SOLVENT AND SECURE. RELIABLE AND CONSISTENT, TRUSTWORTHY.

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CORPORATE

05 06 08 09

BIOTECH & PHARMA

FOOD & NUTRITION

INDUSTRIAL DIVISION

CHEMICAL DIVISION

SERVICES CONTENTS

02 03

A WORLD OF POSSIBLE CLOSE TO YOU

BIO-RESEARCH

10 11

AGRIBUSINESS, FISHERIES, CROP PROTECTION,…

A PIECE OF HISTORY

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WHO WE ARE ND Pharma & Biotech Company Limited, is a research-based biopharmaceutical company that discovers, develops and commercializes innovative medicines in areas of unmet medical needs and operating and conducting businesses in many other fields and sectors, most of them related to human health as food, nutrition, biosciences, neurosciences, and others

ND Pharma & Biotech Co. was founded in 2009 and was incorporated in England and Wales in 2012 as a company limited by shares with a total shares amount of in excess 210 M GBP´s. People behind company foundation accumulates more than 27 years in the field. ND Pharma & Biotech Company brings world-class science and products to the global marketplace in the form of innovative products, materials and services. The company believes that by collaborating with customers, governments, non-governmental-organizations and thought leaders it can be helpful to find solutions to global challenges as providing remedies for certain medical and health conditions that society has to deal now.

The company has access to a large patent portfolio, both owned and licensed. These definite-lived patents cover many products, processes and product uses. These patents protect many aspects of the company's significant research programs and the goods and services it sells. The actual protection afforded by these patents varies from country to country and depends upon the scope of coverage of each individual patent as well as the availability of legal remedies in each country.. The estimated value of total portfolio is situated around the 750 M€, at the end of December 2013. Trade secrets are an important element of the company's intellectual property portfolio of potential future product's marketing.

We contribute to the society thru the improvement of Pharmaceuticals, Biochemicals, API´s, intermediates, reagents, and rare chemicals, trading products, fine and non poisonous ingredients, and many more products, in order to let manufacturers and industry sectors to elaborate healthy foods, beverages, medicines, and many other products suitable for health protection and wellness promotion making it available for people everywhere, meanwhile dependence on toxic chemicals decrease, protecting life and the environment. Our system of collaborative and cooperative work let us to count a total worldwide employment at August 31, of in excess 300 people.

Many of the processes used to make ND Pharma & Biotech products are kept as trade secrets which, from time to time, may be licensed to third parties. ND Pharma & Biotech vigilantly protects all of its intellectual property including its trade secrets. When the Company discovers that its trade secrets have been unlawfully taken, it reports the matter to governmental authorities for investigation and potential criminal action, as appropriate. In addition, the company takes measures to mitigate any potential impact, which may include civil actions seeking redress, restitution and/ or damages based on loss to the company and/or unjust enrichment.

The company runs operations in a number of countries worldwide and about 60 percent of consolidated net sales are made to customers within the EU actually. Subsidiaries, affiliates and licensees of ND Pharma & Biotech Co., conduct manufacturing, production and/or commercial selling activities.

Ownership of and access to intellectual property rights, particularly those relating to biotechnology and innovations in food, nutrition, ingredient´s health, etc., will continue to be important to ND Pharma & Biotech and its competitors.

ND Pharma & Biotech has an established global network of attorneys, agents and experts as well as branding, advertising and licensing professionals, to procure, maintain, protect, enhance and gain value from the IP/PI rights we own and administer.

Constant growth and expansion from Europe to the world, as a premise.

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OUR REASON TO EXIST…


… TO MAKE LIFE BETTER


HIGH VALUES AND A TRULY CLEAR MISSION

Our offer to the market. Most products are marketed primarily through the company's sales force, although in some regions, more emphasis is placed on sales through distributors. The company utilizes numerous suppliers as well as internal sources to supply a wide range of raw materials, energy, supplies, services and equipment. To ensure availability, the company maintains multiple sources for many raw materials. Large volume purchases are generally procured under competitively priced supply contracts. ND Pharma & Biotech company is depositary of a huge portfolio of RDi activities so therefore any commercial activity taken on behalf of The Company is sole responsibility of operating society as trader. Some are distributors of products manufactured by the company. As a science and technology based company, ND Pharma & Biotech competes on a variety of factors such as product quality and performance or specifications, continuity of supply, price, customer service and breadth of product line, depending on the characteristics of the particular market involved and the product or service provided. The environment in which Company competes is characterized by the use among competitors of intellectual property rights, including patent lawsuits, to gain advantage in commercial markets. In support of its business, ND Pharma & Biotech Co. continues to build a large collection of intellectual property rights related to biotechnology and other fields and sectors where the company operates and to license technology from others, including competitors. ND Pharma & Biotech Co., endeavors to obtain such licenses on commercially reasonable terms.

We are revolutionizing industry from the inside with a number of products that we are delivering to a number of countries as a result of the significant expansion and Company´s global reach. We are growing as our clients grow with us. Together will fulfill our goal: making life better.

Innovation & Technology At ND Pharma & Biotech Co., we believe a worldwide company needs to offer outstanding services to every consumer and customer all around the globe. This is why we invest in our World-Class R&D that let us to offer the best-available solutions.

Behind every ND Pharma & Biotech product is our comprehensive global research-and-development network. Our scientists, researchers and technical representatives can help with product development or work with any of your formulations. When you’re ready to test finished products, our sensory testing team can provide objective, detailed evaluations..


Natural Health Protection

The Power of Nature in Your Hands

Science for Nutrition Health Product Benefits •  7 times more bioavailable than folic acid. •  Not affected by MTHFR polymorphism. •  More efficient inner erythrocyte folate content. •  Improvement of homocysteine metabolism.

In foods, approximately 80% of folates are in the form polyglutamates (present in various forms according to its oxidation state and substitution), which during digestion and metabolism are reduced to dihydrofolate (DHF) or tetrahydrofolate (THF). The liver is the best source because folates is the most active form , 5 - metilTHF3 . Folic acid, understood as pteroylmonoglutamic acid, is fully oxidized and that is the synthetic form that normally appears in supplements and enriched or fortified foods. But never in significant amounts naturally.


ND Pharma & Biotech

A World of Possible Close To You ND Pharma & Biotech is a Global Research –Driven Organization and a leading supplier to the pharmaceutical, healthcare and lifescience industries. Our products and services are transforming industrial processes and sectors creating opportunities to our clients and their customers all around the world. We are concerned with the mission of our existence, that´s Making Life Better.

ND Pharma & Biotech has made a commitment to give more hope to the life of today and tomorrow. Bringing ingredients, active principles and novel molecules to the different industries and sharing with most of them, (our clients) such commitment, to let themselves to create, manufacture, and deliver the most advanced solutions to worldwide patients and let them to treat and fight against their aggressive conditions and diseases, specifically in the case of cancer. (Oncology), Neurosciences, Rare and Ultra-Rare Diseases, Food, Nutrition, Agriculture, Fisheries, Pharma, Medical, Healthcare, Research and Development, Innovation, Beverages, Animal Health and a varied number of sectors and fields.


We help Industry and our customers to create really innovative solutions that will make the difference, improving genuinely their lives and the life of affected people an promoting excellence in disease prevention and health maintenance. To get these things possible we are embraced in a number of high-profile / top-class investigations and research, focusing on the discovery of novel molecules and therapies designed and engineered for unmet medical and health demands and conditions, including but not limited to certain types of cancer and oncological diseases as solid tumors, like pancreatic cancer, breast cancer and advanced renal cell carcinoma, as well as other hematological/oncological conditions, Alzheimer´s Disease, Schizophrenia, Depression, Multiple Sclerosis, Lateral Amyotrophic Sclerosis, Infections, Tropical Health, Stem Cells, and a multiple-lines of open investigation and innovation.

Over a century ago, Lonza began as a small Swiss electricity company, producing a few chemicals on the banks of the river Lonza in the Valais region of the Swiss Alps. Today, Lonza is a leading supplier to the pharmaceutical, healthcare, and lifescience Since our industries. inception to the present day we combine

ND Pharma & Biotech at-a-glance We provide and suppor t industry with active pharmaceutical ingredients both chemically and biotechnologically. Biopharmaceuticals are one of the key growth basements of the pharmaceutical and biotechnological industries.

Lonza at-a-glance

ND Pharma & Biotech developed high performance

Lonza is the global leader in the production and support of active pharmolecules, both large and small, amino acids, maceutical ingredients both chemically andpeptides, biotechnologically. Biopharand niche play an important role in theand maceuticals arebioproducts one of the keythat growth drivers of the pharmaceutical biotechnology industries. development of novel medicines, healthcare products,

and other important milestones that make our lives

Lonza has strong capabilities in large and small molecules, peptides, better. Furthermore, our company is a leading provider amino acids and niche bioproducts which play an important role in the deof chemical and biotech ingredients to the nutrition, velopment of novel medicines and healthcare products. In addition, Lonza is ahygiene, leader in preservation, cell-based research, endotoxin detection and cell therapy agro and personal care markets. manufacturing. Furthermore, the company is a leading provider of chemical Our and biotech to the nutrition, hygiene, preservation, cultureingredients of service and professional reputation agro is andvalued personalbycare markets. all our deeply appreciated customers today.

cutting edge R+D+I with the experience of our dedicated team, a driven group of professionals with a motivated and entrepreneurial character able to adapt the offerings in product and services to the needs of customers and the ever-changing technological environ. From 1897 to the present day combining Swiss tradition with global

The following pages will give you an overview of our experience, the company has had an enterprising character, adapting main operational markets principal and areas for its offerings and services to theand needsthe of customers to changing technologies. Throughout history, we have maintained a strong our business from our Pharmaceuticals, Research, culture of performance, results, and dependability that is valued Biotechnology, Food & Nutrition, Agribusiness, Materialsby all of our customers. and Construction, Personal Care, and many others. The following pages provide an overview over our seven markets: Bio-

Our Reference Product Catalogue is over 200.000 Research, Pharma&Biotech, Nutrition, MicrobialControl, Agriculture, articles today, with an impressive stock of 11.500 preMaterialsScience and PersonalCare. packed and ready-to-go products, including the latest The matrix belowand shows which business units which developments branded products weserve place on markets. sale.

Some of The Markets we serve thru our Divisions and/or Business Units Divisions – Business Units Life Science Ingredients Markets BioResearch Pharma&Biotech Nutrition MicrobialControl Agriculture MaterialsScience PersonalCare

Nutrition Ingredients Microbial Control Performance Intermediates

Custom Manufacturing Chemical Manufacturing Biological Manufacturing Development Services

Bioscience

Therapeutic Cell Solutions Testing Solutions Research Solutions


ND Pharma & Biotech BIO-RESEARCH

Products and Services to make from your research experience an optimal one. Bioresearch Markets are part of our target with cell and molecular biology products and other references for basic drug discovery and applied research.

But our mission, do not appear only when the disease is onset and clinically evolved. We are going further back to the point of participate throughout our Food & Nutrition Division, on the most extensive detoxification programs and products (broad consumption), till the point of making possible our vision of removal the chemical – toxic elements and cellular waste deposits present within our body, and coming up from the food and alimentary chain, mean, ingested within foods. In this effort we are praying to get every producer, processor or seller involved with this ideal, that are for us the true reason for living and doing what we do, and every other effort that we should have to do,. By such means we are promoting and cultivating the meaningful spirit of making life better, just making things much better than any others are doing it now. That is the hope for tomorrow that challenges us.


Life-Sciences Research is always in need o different tools to discover biological pathways and to develop new drugs and therapies for illnesses and diseases, form common to rare and ultra-rare. We provide with such tools to academic, institutional and research +innovation centres worldwide.

Products and Services for Life-Sciences As far as we are a research-based/commercial-stage biopharmaceutical company dedicated to the identification, development and commercialization of novel therapies that improve function in people affected by a number of medical conditions in a variety of complexities and situations, no matter what clinical stage they reached as it happens in multiple sclerosis, or MS, spinal cord injury, or SCI, and other disorders of the nervous system, as example, we have a deep and thorough understanding of research needs. We have marketed evolutionary active principles and molecules as well as developmental stage products and are working to bring important new therapies to people with different disorders. Our goal is to help patients to a better future, while building a leading neurology company with a portfolio of innovative products. We help scientists and researchers around the world to develop work that let them to discover new therapies and treatments for live-threatening conditions and diseases and therefore to save lives. From certain technologies to product standards we deliver a complete range of reagents, molecules, consumables, etc. to meet the needs of our customers within this complex and ever-changing environment. For drug discovery we offer products and services regarding to specific conditions and research related areas such as Alzheimer´s Disease, Oncology, Central Ner vous System, Cardiovascular, Respiratory, Obesity and other including certain rare and ultra-rare syndromes.

As example, Approximately 400,000 people in the U.S. suffer from MS, and each year approximately 10,000 people in the U.S. are newly diagnosed. Research indicates that 64% to 85% of those people experience walking disability and that 70% of people with MS who have difficulty walking report it to be the most challenging aspect of their MS. Within 15 years of an MS diagnosis, 50% of people with MS often require assistance walking and, in later stages, up to one third are unable to walk. Even in early stages of the disease, walking can be a significant issue; one study found that 28% of people reported walking disabilities within two years of MS diagnosis. In the European Union (EU), approximately 600,000 people suffer from MS, and an additional 55,000 to 75,000 people in Canada are also diagnosed with this disease. We are developing what we believe is an industry leading pipeline of novel therapies. We are developing novel treatments for selected, refractory patients with epilepsy, schizophrenia and/or headache, facial pain and trigeminal neuralgia as well as others based on stable regimens of antiepileptic drugs, or AEDs, or single-dose treatment for those who require intermittent use of certain molecules to control bouts of increased activity also known as cluster or acute repetitive episodically onsets, or AREO´s. We are also studying new treatment frontiers to improve a range of functional impairments, in addition to walking disability, caused by MS, as well as its potential use of other peptide and non-peptide derived molecules in other neurological conditions, including cerebral palsy and post-stroke deficits. In addition, we are developing clinical stage compounds for acute treatment of SCI, different novel approaches for treatment of heart failure, and a highly promissory compound and formula based on a specific remyelinating monoclonal antibody, for the treatment of MS.


Company is intending to be a leader in Life Sciences and High Technology. The Company develops, manufactures, purchases and distributes on of the broadest range of high quality chemicals, Biochemicals, branded products and industry solutions as well as certain equipment available throughout the world and also provides global biopharmaceutical services including research and development of food, nutrition, research, biology, pharmaceutical, biopharmaceutical, biotechnology, medical, healthcare, agriculture and veterinary products, between other sectors. These products, kits and services are used in scientific research, including genomic and proteomic research, biotechnology, pharmaceutical development and as key components in pharmaceutical, diagnostic and offer high tech manufacturing. The Company operates in a number of countries, with a plant and storage manufacturing approximately 52.000 of the more than 170.000 chemical and biochemical products we offer.

Our Business

The company sells worldwide both directly and through a net of commercial entities and other agents/distributor 'schemes having an ever-growing portfolio of customers and clients spread into approximately 160 countries where we are servicing products.

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a question of beliefs ! !


The Company provides products and services that focus on:" "

research customers that use smaller quantities of our products in basic life science and high-technology R&D;" manufacturing customers that use our products in larger quantities in lab-stage development and manufacturing; " Products & life science customers who use our biopharmaceutical products and services to the development, manufacturing and commercialization of biological and Services facilitate chemical drugs; and" industrial and diagnostic companies that use our products in various forms of assays and testing as well as in clinical diagnostics." " The 3 main areas of business are: " " Research provides reagents and consumables to life sciences and non-profit research organizations. " Applied provides raw materials and solutions for testing in clinical and industrial applications. " Commercial provides manufacturing raw materials for commercial products throughout its own divisions.


ND Pharma & Biotech BIOTECH & PHARMA

We support emerging and wellestablished companies and innovation centres in the pursuing of novel therapeutics at all the involved stages from commercial supply to manufacturing placing our expertise and technology to customer´s service to reach top quality products.

Creating new opportunities in the discovery of novel therapies,‌ turning it into real cures.

We vigorously invest in research, development and innovation to discover and develop new products and eventually, new treatments that meet the needs of specialty doctors and their patients. Our company try to develop world-class research + development + innovation (R&D) programs that embodies our efforts to bring the best of science to medicine and therefore to life, including some new developments within the nutrition science, food, feed and certain industrial sectors. Scientists and researchers work closely with specialists within their respective areas, to transform novel compounds into new therapeutics and products that help improve quality of life. This philosophy is consistent with our motto; Making Life Better. Our commitment to R&D has been evident since our inception, when we began pioneering new treatments to help preserve certain organic and body functions including neurological functions as memory and cognoscitive abilities. Since then, our investment in R&D+i has progressively increased to a level that is considered best in class for the industry, and we have followed our products into new specialty areas.


Our R&D+i programs today are focused in many areas ranging from diabetes and nutrition to surgical innovations. Currently, we are investigating a rich arsenal of potential new treatments for chronic migraine, debilitating neurological conditions, eye disease, and stem cell transplantation, among other conditions and fields. !

Products and Services for Biotech & Pharma Since founding, our company retains the ability to listen and to learn - from our customers, and from each other - has been a cornerstone of our success. ND Pharma & Biotech´s R&D+i culture reflects this, providing an open forum for our and other scientists to share ideas, collaborate on projects, and gain access to the latest research. Access to world-class technology combined with intellectual stimulation results in a dynamic environment where scientists are excited about the work they do and committed to pushing the boundaries of what is possible. Partner of Choice ND Pharma continues to be the partner of choice for customers looking for an edge in the pharmaceutical and biotech market. Our industry-leading products and services have helped companies of every size, at every stage of development increase quality, enhance their manufacturing processes, remove bottlenecks, reduce time to result achievement, improve regulatory compliance, and lower assay and production costs. Quality Through Innovation Innovation is within our nature. It is the way we work, which is why we are able to offer the pharmaceutical and biotech markets advanced technologies that transform life science into new possibilities. We know and recognize that every organization has its own unique needs and such needs are likely to change over time as organizations evolve thoroughly. So throughout our relationship, we innovate, we remain flexible, we adapt and we continue to adjust as goals and objectives may change to reach success.!!

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Our R&D+i organization is structured into integrated teams that focus on discovery for different targets. This unique architecture affords many benefits. Scientists normally confined to specific tracks have the opportunity to be involved in the full life-cycle of development, from early-stage exploration to human testing, for a much broader perspective. Additionally, meticulous research is streamlined with highly efficient project and information management, which can save years and millions of dollars from the overall cost of drug development. Most of our discovery and development programs are initiated internally, which sets us apart from many other health care companies. Simultaneously, we explore new market opportunities and search for partnerships to develop superior technologies that are complementary to our own business model. In short, at our company, there will be only one way in which we view the purpose of science and innovation - to identify those needs in health care and certain industrial sectors that are unsolved and commit to finding solutions through a meaningful R&D+i investment that fuels future growth. This is our unwavering commitment. For every new treatment/product that comes to market, hundreds of important discoveries are made along the way that contribute to science, medicine, health and technology. For these contributions and many others, ND Pharma & Biotech provides several opportunities for our scientists to be recognized and rewarded for excellent work in their respective fields and broadly.


Clean Label Ingredients Cutting Dairy Costs

Consumers are demanding shorter labels, and desert producers in particular require ingredients to actively improve shelf-life, taste, functionality and appearance. As the number of consumers looking for a simple-easily understood ingredient statement grows, the open declaration is becoming increasingly important for food producers. PreserFood TM/Dairy is the ultimate in Clean Label ingredient麓s technology. With more than 40 different functionalities, our product is the answer producers and processors were waiting for. The answer consumers are looking for and the cutting edge innovation.

PreserFoodTM/Dairy Nature Protection for Milk路Nature Protection for Life

www.ndpharmabiotech.com


PepperSol TM Ultrapure Black Pepper Extract

Recently published studies appeared within peer-reviewed journals appears to demonstrate that pepper pure extract (Piperine), a self affirmed GRAS ingredient has the effect of to enhance the bioavailability of certain wine components as Resveratrol, CoQ10, Vitamins and Minerals up to a 300%, in comparison with the actual presentation of such components within certain foods and beverages that contain such. Resveratrol is the main polyphenol present in Red Wine. Our proprietary extraction and purification system and exclusive grain fusion technology let us to reach a product 98% Pure Piperine (water and alcohol soluble). PepperSolTM, has been clinically proven and reached classification as thermo-nutrient and bio-enhancer of a variety of other ingredients from Curcumin to CoQ10, Vitamins, Minerals, including Resveratrol, etc. PepperSolTM is a clinically and research proved bio-enhancer of certain nutrients and food-component ingredients of multiple-source, with applications all across the Food & Beverage Industry. PepperSolTM is pure pepper extract with natural capacity to enhance bioavailability of certain nutrients, with applications on the natural health and nutrition fields.

Black Pepper (piper nigrum)

www.ndpharmabiotech.com Š2015 ND Pharma & Biotech Co. info@ndpharmabiotech.com These statements have not been evaluated by the FDA/EFSA or any other agency. This product is not intended to diagnose, treat, cure and/or prevent any disease.

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ND Pharma & Biotech FOOD & NURITION

To add value to our customer´s products and formulas is at the core of our Food & Nutrition Division. We include Food, Feed, and Health (Special Nutrition, Hospital Nutrition), and many other sections of the Division within the scope of this important area for us.

Nutritional Ingredients, Special Formulas, Improved Molecules, Food, Nutrition, Health, ‌Every aspect count for us.

Our division of Food & Nutrition is gaining development every day and awakening conscience about the urgent necessities of the modern world and society. We are living and experiencing a world boom ahead of us in terms of population, health, fight to the poverty and famine, and other important political, economic and social issues. Within this future, food and healthy foods for a correct nutrition will have to be supplied to more and more people every day. We want our products being part of this evolution, and this is why we research and developed products, services, ingredients and other important creations to make food, nutrition and health, more accessible to consumers, giving extra quality and safety to foods, specially those processed and elaborated, helping industry to avoid chemical-toxic substances with a high potential harmful effects and its use within the manufacturing and processing of such products. This is why we are adhered to the Green Chemistry Initiative, taking leader positioning in the global approach to chemical substances management, engaging with all industry operators into a new wave of thinking and action to develop and promote an effective, scientific and risk-based approach to the use of toxic chemicals within our everyday live, specially foods.


Nutrition for Health, Nutrition for Life

Unique Knowledge Our company has taken contact with a number od national, regional, local and state agencies and regulatory bodies to ensure that rational, scientific and risk based approaches to chemical management and assessment are embodied into federal and state legislation and regulations, that infor med substitution is the centerpiece of alternative assessment about the concerns rising from the massive proliferation of chemicals that actually is not managed both effectively and efficiently.

Unique Solutions Our company is constantly exploring some of the most important food and chemical-related science policy issues to generate enough documentary evidence and attract to consumers to take action and responsibility thru key scientific ar ticles, r egulation consider ations and food and beverage applications as well as market insights.

The commitment of ND Pharma & Biotech Pharma is much more than a commitment with product quality. It is a firm commitment to the perfection of a complete line of products ranging from those that stay and maintain fresh and tender food commodities to the methods, products and technologies capable of removing bacteria, toxic chemicals or radioactive elements from foodstuffs. Our products are made to fit the needs of our customers and composed with authorized ingredients worldwide and regarded as GRAS / E (Generally Recognized As Safe / Effective) by bodies such as the American FDA and European EFSA. Our real interest is in the development and realization of finished products to obtain the best results possible without the intervention of toxic substances chemicals that have been included and are still present in many food commodities worldwide, (sometimes hiding the presence of those to the authorities and consumers). Our products are developed in a clear commitment with the highest standards of technical quality and therefore, we make sure these are kept free of allergens and are obtained mostly by natural processes from vegetable raw materials, minerals and other carefully chosen its origin, extraction methods and other important characteristics of these. Our products are designed for different stages of implementation in the industrial process, from the collectors, who benefit from our line called VegaFresh TM processors until they have at their disposal a wide variety of products such as the PreserFood TM, LactoLife TM or FruitFresh TM to the marketer that has other like the well known SterilFood TM as the homemaker to which our product lines are offered with different presentations of the same compounds. Our products can be consumed by virtually all ethnic groups present on the planet. This ensures that our raw materials base and active ingredients from its origin possess the appropriate certifications Kosher, Halal, and the Muslim community, among others, and where these will be consumed.

High Quality Ingredients Top Market Brands Our expertise run into multiple applications in Food, Nutrition and Nutritional Health from fortification to infant formulas, dietary supplements, functional, Sports Nutrition, Hospital Nutrition and much more. 7


At ND Pharma & Biotech everything starts with a pencil and a blank sheet, a mindfulness brain just thinking about solutions for unsolved problems and concerns expressed by our clients from many different sectors and fields. To find solutions is the only way we know to enhance your true understanding about who we are. !

www.ndpharmabiotech.com


We Make Things Happen

SUSTAINABLE SCIENCE FOR LIFE 路 DELIVERED ACROSS THE WORLD

www.ndpharmabiotech.com

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ND Pharma & Biotech SERVICES & PARTNERSHIPS

Our company has the c o m p r e h e n s i v e r a n ge o f products and services from research to pharmaceutical and clinical development including the commer cialization of products. Privately owned, financially stable. Innovation, efficiency and business success and long-lasting relationships.

We offer one contract for all our services providing security, trust and confidence letting our customers to avoid the burden and risks of management associated with multiple vendors and/or suppliers. Our particular system of project management enables efficient progress through research, innovation and development reducing time to market whilst ensures scientific continuity. We exceed customer expectations thanks to our dedicated team of professionals and scientists, our partners and industrial associates and their employees that give us enough feedback to maintain our outstanding quality records and service.

Biomarker Discovery & Development API Services & Chemical Development Pharmaceutical Development Analytical Serices Clinical Trial Study Clinical Technology Commercial Services Biopharmaceutical Food & Nutrition Agribusiness Veterinary Fine Chemicals & NCE´s

ND PHARMA & BIOTECH LTD., is a private owned company with partnerships and industrial operated facilities in the UK and the US, China and South America. The Company is incorporated in England & Wales which is also the main country of operations for administrative and social purposes. The Company is developing active industrial and commercial promotion and activity in several regions characterized by geographical areas, Europe, Africa and Mid-East Countries (EMEA), Asia, and The Americas, with representatives in these areas established and other in constant expansion and growing. We owned also commercial societies and distribution networks that are truly part of our own business both trough subsidiary companies, representation Offices and Regional and National Branch Offices worldwide.


Core Values & Vision ND Pharma & Biotech is committed to not only meeting your needs, but exceeding your expectations, as evidenced through our core values: Outstanding Quality ND Pharma & Biotech commitment to quality is guaranteed through a comprehensive range of standard operating procedures and fully documented quality systems developed in accordance with global pharmaceutical guidelines. Health, safety and environmental issues are of paramount importance and significant emphasis is placed on recycling and waste management throughout the Company. We pride ourselves in our transparent quality guarantee and invite all existing and prospective customers to test our possibilities and capacity to let them to experience our superior quality standards. Exceptional Innovation ND Pharma & Biotech is dedicated to solving important and challenging problems. We do this by promoting an environment where extending the boundaries of knowledge, technology and creativity is encouraged. Our specialist, in-house engineering and technological capabilities enable us to facilitate the rapid turnaround of bespoke systems and equipment designed to meet the individual requirements of each and every project. We continually strive to identify, design and implement novel and exciting methods of delivering industry-leading solutions which ultimately accelerate the drug development process. Superlative Customer Focus We are committed to understanding and exceeding our customers’ needs and expectations. We build relationships based on integrity, responsiveness and excellent communication. As a client-focused, customer-service leader, we become a seamless extension of our industry partners. Our dedicated Project Management and Business Development teams are proactively engaged with our customers on a truly global scale, committed to constant communication and frequent face-to-face meetings. ND Pharma & Biotech prides itself in providing a personalized service to meet the requirements of all our customers regardless of their location. We consider corporate social responsibility to be vital and fully embrace our responsibilities regarding the impact of our activities on our customers, employees, communities and the environment in all aspects of our operations. By listening to our customers’ requirements, we implement new methods of expediting delivery of project objectives.

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ND Pharma & Biotech creates to serve all sectors of industry and specifically those reluctant to renounce to the use of sugar within their elaborated/manufactured products as ingredient.

is a complete sugar-based ingredient´s formula with a cuttingedge innovation process able to reduce naturally the amount and speed of sugar absorbed by organism up to a 50% less, reducing GI(Glycaemic Index) peaks and Insulin-Reactive response.

Every ingest of sugar will count just as much as 50% of total eaten, protecting thus far consumer´s health in a nutritional, safe and effective, natural tasty way.

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www.ndpharmabiotech.com1


You´ll Love Our Sugar ND Pharma & Biotech creates SUGAR20TM to serve all sectors of industry and specifically those reluctant to renounce to the use of sugar within their elaborated/manufactured products as ingredient.

SUGAR20TM is a complete sugar-based ingredient´s formula with a cuttingedge innovation process able to reduce naturally the amount and speed of sugar absorbed by organism up to a 80% less, reducing GI(Glycaemic Index) peaks and Insulin-Reactive response.

Every ingest of sugar will count just as much as 20% of total eaten, protecting thus far consumer´s health in a nutritional, safe and effective, natural tasty way.

YOU´LL LOVE OUR SUGAR BECAUSE OUR SUGAR DO CARE FOR YOU Simple,(Fast(and(Easy(

info@ndpharmabiotech.com11 1(Ref:%Sugar20%TM)1 7

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ND Pharma & Biotech INDUSTRIAL DIVISION

Innovative global solutions for the industry We offer quality of service and support to industry and industrial sectors through this important division in the areas of quality, management, regulation, compliance and development, all basic pillars of the industrial progress and success, in a variety of sectors, fields and applications.

Our company offers different advanced and imaginative solutions for the industrial, professional and artisan varied sectors from food, Feed, Pharma, Biotech or NCE´s (Novel Chemical Entities) development to Special Molecules, including rare and ultrarare all within an impressive array and product portfolio that is over 160.000 product references nowadays. From most classic raw materials to the most advanced ones, our developments and brand products are specially and specifically designed and engineered to help in the solve of any individual problem planted by our partners, clients, and collaborative industry in general. We follow researching and growing up to offer to you every day the best within us, always. We observe permanently our goals and mission as company and of course our strict values, far more than just a business philosophy. Deserving your trust and confidence.


ND Pharma & Biotech; Innovative Minds in Action CUSTOM PRODUCTS

THE INDUSTRIAL DIVISION Our Industrial Division is comprised by different sections from Project Management to the provision of products and ser vices at very different scales. To evaluate the possibilities and options that we can offer to help your business to grow, please contact us in write to the following e-mail address. One of our personal attendants will contact you back.

CONSUMER PROTECTION Fortunately, consumers are more committed every day to protect their health and the health of their families, as well as the knowledge of those healthy or harmful elements from different types of industries that can affect (and the food industry is one of these).Therefore at ND Pharma & Biotech, we are fully committed to health, health protection and consumers in gener al, within a business philosophy consistent with the times and the changes that these new times behave in terms of energy conservation, sustainability and distribution and optimization of available resources, as we are aware that these are not eternal.

From a selection of our range of products and multiple lines, ND Pharma & Biotech provides customers the opportunity to work closely with our scientists, in order to achieve developments and products that meet the needs of our customers are demanding. This service, despite being generally available and accessible to any company or customer (potential or actual) is a restricted service for existing customers of our company, so there is no commitment to provide this service or provide any other person or company, except that such services are performed by our scientific department under contract or specific agreement. The development of customized products is an arduous, complex seen from the point of view of technology and resources, and therefore be reserved as a reward for loyalty and trust of customers who really have a clear business vision and social responsibility convergent with our company interests, especially with regard to the elimination of production lines, chemical toxic elements harmful or detrimental to the health of consumers. CREATING VALUE WITHIN YOUR COMPANY The use of our products, preparations and compounds, means for the producer, the merchant and the consumer not only a guarantee of freshness, quality and durability of the products your company produce or sell. In fact, the use of our products provides added value difficult to assess in advance by the customers themselves, but that is evident and manifest for our users as they grow, and outlook, increasing their margins, (the longer the duration less waste and therefore less impact on losses), increasing sales, (actually more durability means to reach more markets and distances), and providing their own brand of a guarantee of food security and health which until now was difficult to achieve or simply impossible to obtain. At each step, our own customers report discoveries and improvements that had not even discovered in our research and in fact, can only be found when our products are applied on the ground, and under the complex and harsh conditions that each producer, processor or manufacturer knows and lives every day and in his own skin. Thus, recent studies show that our products, in example, added to infant formula and other milk preparations help fight (especially in certain countries) diarrheal disease, or causes the reduction of by-products such as acrylamide or GEA when food sources are subject either during processing or in cooking at temperatures above 100 degrees Celsius, with the consequent benefit to the general population health. Occasionally, our products are used by manufacturing companies, such as stabilizers and reinforcements net nutritional food commodities for disadvantaged populations or people with special nutritional needs (PARNUTS), reasons why the European authority on food safety, has ranked some of our components or active ingredients as natural and suitable to provide these groups (patients, diabetics, children, immune-compromised, developing countries, etc..) part of the nutritional requirements they need. The creation of value in those companies among our clients, ultimately resulting in an actual and target levels and degrees of satisfaction by both parties, and the security and confidence that together, we took our committed to the standards of excellence that we desire. Excellence is undoubtedly one of our goals. 7


ALKIOW, from ALKaline IOnized Water is a WHOLLY NATURAL MINERAL bioreactive method and product developed by ND Pharma & Biotech that let anyone to transform regular water, (mineral, tap or current) into ALAKLINE IONIZED WATER in just seconds, without discomfort of apparel, maintenances, supplies, with an easy teardrop just into the water wished to transform. Special mineral formula, lower costs and higher technology for health protection and wellness, makes ALKIOW TM and unparalleled and unrivaled product worldwide.

! Natural Stabilization – Optimal Nutrition


Pharma & Biotech Making Life Better

ND

For more information on the benefits of PTerosolTM 7 and alternative formulas to include in your products, contact us at: info@ndpharmabiotech.com


ND Pharma & Biotech CHEMICAL DIVISION

Our offer of chemicals, API´s and other molecular solutions is based on experience, trust, quality and reliable sourcing of materials. We partner with companies and suppliers managing state-of-the-art facilities and custom manufacturing technologies to offer to our clients and the markets they serve and operate the very best of available.

World class and ultra premium manufacturing of active ingredients creating value within every client and market that we enter‌

From construction and building to life sciences, from medicine to agriculture, ND Pharma & biotech is offering solutions that deliver high-performance, cost-effective raw materials and advanced science performance. We have a strong commitment with those products that enable customers to optimize production reliability with high quality delivery service, enter new applications in the market through innovative materials and to expand their markets by adding higher performance to their products. All areas of the business, starting from raw materials over high performance to protection and materials properties extension is operated under high standards for quality control and quality assurance. Our Chemical Division can deal almost with every existing molecule and material on the planet. We offer also counseling service and consulting services for new developments and directed and fully experienced project management under contracting.


Formulation, Preservation, Sustainable Innovation THE CHEMICAL DIVISION We pray for the use of sustainable and green chemical production systems and methods. We embrace the Green Chemical initiative from our natural inception and creation as inde pendent company. We promote and establish as the leaders in the field different ecofriendly and sustainable initiatives within the different sector we are. CHEMICALS FROM A to Z. Our compromise goes further than the compromise with the quality of a particular product. It´s a firm bet for perfection of a complete line of products and ser vices. Such products, for instance are taylormade manufactured and composed by completely audited and inspected sources, quality verified, the vast majority classified under GRAS or GRAS self affirmed as it happens within the Food & Nutrition fields by European and North American regulatory bodies, and certified by GMP/EP/USP/ cGMP, etc., as it happens within our nutraceuticals, health ingredients, API´s, and all the others in house.

GENERAL CHEMICALS CATALOGUE We offer not only a selection of products, ranging between our more than 160.000 references. We offer also the opportunity of co-work with our teams of technicians, scientists, researchers and other valued personnel, hand by hand to reach goals, and development of innovative products that may fulfill with all the needs of our beloved clients. That service, despite the fact that is generally available for customers, and being accessible to any potential interested customer/candidate is in a certain way restricted to a certain clients of our company accomplishing a number of requisites. TAILOR-MADE PRODUCT DEVELOPMENT The use of our products, preparations and compounds, means for the producer, the merchant and the consumer not only a guarantee of freshness, quality and durability of the products your company produce or sell. In fact, the use of our products provides added value difficult to assess in advance by the customers themselves, but that is evident and manifest for our users as they grow, and outlook, increasing their margins, (the longer the duration less waste and therefore less impact on losses), increasing sales, (actually more durability means to reach more markets and distances), and providing their own brand of a guarantee of food security and health which until now was difficult to achieve or simply impossible to obtain. At each step, our own customers report discoveries and improvements that had not even discovered in our research and in fact, can only be found when our products are applied on the ground, and under the complex and harsh conditions that each producer, processor or manufacturer knows and lives every day and in his own skin. Thus, recent studies show that our products, in example, added to infant formula and other milk preparations help fight (especially in certain countries) diarrheal disease, or causes the reduction of by-products such as acrylamide or GEA when food sources are subject either during processing or in cooking at temperatures above 100 degrees Celsius, with the consequent benefit to the general population health. Occasionally, our products are used by manufacturing companies, such as stabilizers and reinforcements net nutritional food commodities for disadvantaged populations or people with special nutritional needs (PARNUTS), reasons why the European authority on food safety, has ranked some of our components or active ingredients as natural and suitable to provide these groups (patients, diabetics, children, immune-compromised, developing countries, etc..) part of the nutritional requirements they need. The creation of value in those companies among our clients, ultimately resulting in an actual and target levels and degrees of satisfaction by both parties, and the security and confidence that together, we took our committed to the standards of excellence that we desire. Excellence is undoubtedly one of our goals.

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A Sustainable

Business Model and GROWTH CODE OF ETHICS AND VALUES

A Sustainable business model for a better growing. ND Pharma & Biotech is a responsible company that enforce and develop a strategy based on the long-term. As researchers, we are conscious that the support of every function within the Company is a demanding task and implies the cooperation of every and one people in service to the company

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Our Code of Ethics promotes between others two main concepts of value and high moral standard that can be resumed as follows: •  Economic and Financial active fighting against corruption and illegal business practices. •  Social Respect for the diversity and cultural differences while there should be a constant surveillance on the risks related to health, safety and environment. •  Active involvement in public interest issues and affairs.

GLOBAL LEADERSHIP IN NCE´s Our company aspires to be a world leader in Innovation and Evolutionary developments. Thanks to our position and available molecules, raw materials and novel molecules, including those classified as rare and ultra-rare, hard-tosource compounds are our specialty. The advancements our scientists and researchers may provide on the ground of that existing molecules and compounds will be an important part of our business development in the future, both in the mid and long-term perspective.

+160.000 PRODUCTS IN OFFER Compromise with Total Customer Satisfaction.

From analytical and chromatography to life sciences, chemistry, material science, we strive on technical bulletins, publications, tutorials, product guides and all kind of tools to let you get maximum profit from our products, molecules and compounds. We serve a full spectrum of industries giving to them the quality and service they deserve. This is our commitment to excellence.


Life Sciences and TECHNOLOGY

Company focus

RESEARCH

As a leading Life Science and High Technology company, some of our products are used in scientific research, biotechnology, pharmaceutical and biopharmaceutical industry and development, diagnosis of disease and key components in drugs, therapies and cures for certain medical conditions and illnesses.

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Creating Milestones in Advanced Research.

This business unit is focused on service to clients from different fields from academia to government labs as well as companies in the food, nutrition, health and medical sectors, including pharmaceuticals and biopharmaceuticals. The aim of this unit is to develop innovative tools and solutions to let our clients to enter into the complex areas of research that are demanding solutions in the evolved and ever-growing society. We have created a leading portfolio of chemicals and biological compounds that is growing to impulse our sales channels.

COMMERCIAL This business unit serves customers that are in the business of manufacturing final products from different sectors from life sciences to construction and building or electronics. Our customers require certain raw materials that have an important impact on the performance of their industries and businesses as well as over their final products and competitive capacity. Our aim is to play an integral role in their business providing the molecules, compounds and products that they demand constantly.

APPLIED Market for our products and solutions are growing exponentially as far as is growing the amount of clients and prospective clients that are using our products or analogues in their ordinary business and production. We want to be focused also in that kind of client. Those companies will be profiting from the use of advanced solutions and research from us, since they are not in the position for developing their own technologies and science.

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ND Pharma & Biotech AGRICULTURE FISHERIES CROP PROTECTION …and MORE

Custom product development is a difficult and technological complex issue, and also a demanding task from every point of view…

We offer a number of solutions from crop protection to fisheries, manufactured products, agrochemicals, chemical intermediates, and Biotech cutting edge advances as the STD-Microgene (Salt Tolerant Development Plants), a revolution within the field for coastal and sea-salt affected lands.

We are extremely successful within the product development area, from the very simple blending and mixture formulas to the differential presentations, solid, liquids, solution, etc. We offer trade and scale commerce of branded products including general chemicals, certain commodities and other referenced materials in virtually all kind of packaging formats. We provide a specific catalogue and our technical teams are ready to offer counseling and updating our customers with the latest developments and technologies available. Our customers may explore within our complete and highly extensive reference ´s library of products including but not limited to +600 Trading Products, +12.600 AP´s, +68.000 Molecules and Combinations and the Spectacular library of + 150.000 NCE´s (Novel Chemical Entities), that are our best kept widespread secret asset nowadays.


We care for our customers deeply and thorough. THE AGRIBUSINESS DIVISION

Partner of Choice

We offer confidential consultative services to each project providing insight critical to commercial success. We help customers bring products to market faster and more effectively by sharing our extensive for mulation and regulatory expertise.

ND Pharma & Biotech continues to be the partner of choice for customers looking for an edge in the chemical, biological, pharmaceutical and biotechnology markets. Our industry-leading products and services have helped companies of every size, at every stage of development increase quality, enhance their manufacturing processes, remove bottlenecks, reduce time to results, improve regulatory compliance, and lowering costs. Our broad experience in several fields and techniques from advanced chemical and peptide synthesis to cellular and gene therapies allow our customers to advance their products to market faster and more efficiently.

UNIQUE SOLUTIONS INNOVATION Our portfolio includes innovative solutions, including naturally derived materials from renewable resources. Our solutions assure and improve product safety providing guaranteed quality for consumers. We leverage our strengths in microbial control, nutrition, biosciences and target unmet needs of the personal care industr y. We contribute to innovation in many fields through leading-edge, multifunctional ingredients that expand the claims for your brands and create new for mulation possibilities and product extension functionalities.

Practical Knowledge As service providers, we understand the day- to-day challenges pharmaceutical and biotechnology innovators face, and we’re driven to find answers. Often this means delivering one of our cutting-edge products, such as a sustainable alternatives. Other times, it means leveraging our broad-based manufacturing and development experience with small and large molecules, primary and stem cell expansion, protein design and cell-line construction to provide a tailored solution that meets your immediate and long- term objectives.

Innovation is in our nature. It is the way we work, which is why we are able to offer the pharmaceutical and biotech market advanced technologies that transform life science into new possibilities. We recognize that every organization has unique needs and those needs are likely to change over time. So throughout our relationship, we innovate, we remain flexible, we adapt and we continue to adjust as goals change.

Taking You to the Next Level At ND Pharma & Biotech, we continually to strive to enhance our offering to meet growing customer demands for next generation therapeutics. Our latest developments, agreements and partnerships with leading –edge high class performance multi-billion dollar companies demonstrate our commitment to the life-science market. At any stage of your program – whether investigating a new drug com- pound, choosing a lead candidate, optimizing a process, scaling-up, or evaluating the quality and safety of products, our life-cycle management experience and innovative solutions give you the peace of mind you expect.

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Business Model of DISCOVERY

A Sustainable

PRODUCTS WE OFFER

Our core mission is to help science and industry to improve the quality of life of people throughout our efforts in research and discovery and its applications to commercial markets. We are committed to deliver and supply the highest quality of products in deep collaboration with our partners, customers and agents.

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A stable and solid financial structure, allowing us to focus on continuous development and long-term activities.

ANTIBODIES BIOCHEMICALS REAGENTS BUFFERS CELL CULTURE CELLS CELL-BASED ASSAYS HEMATOLOGY HISTOLOGY MOLECULAR BIOLOGY

CELL-SIGNALLING NEUROSCIENCES ENZYMES INHIBITORS SUBSTRATES FUCNTIONAL GENOMICS RNAi PCR AMPLIFICATION PROTEOMICS WESTERN BLOTTING

RESEARCH AREAS CANCER RESEARCH CELL BIOLOGY/CELL SIGNALING DRUG DISCOVERY EPIGENETICS FUNCTIONAL GENOMICS METABOLOMICS MICROBIOLOGY MOLECULAR BIOLOGY NUTRITION RESEARCH

OBESITY RESEARCH PLANT BIOTECHNOLOGY PROTEOMICS DIABETES ALZHEIMER´S SCHIZOPHRENIA STEM CELL BIOLOGY METABOILISM ETC.

CORPORATE Responsibility From analytical and chromatography to life sciences, chemistry, material science, we strive on technical bulletins, publications, tutorials, product guides and all kind of tools to let you get maximum profit from our products, molecules and compounds. We serve a full spectrum of industries giving to them the quality and service they deserve. This is our commitment to excellence.


A Strong Constant

Global EXPANSION

A strong constant global expansion that makes us stronger in certain fields, countries and territories is the vision behind our aim. To achieve this objective we do not hesitate in forming different kinds of association agreements, joint ventures, partnerships and sometimes entering in the impulse of certain spin-offs with some of our existing development partners worldwide.

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We are committed with an ever-growing commercial development policy that relies on agents, distributors and other representatives as well as company locations. We create partnerships with other companies, industries and operators with solvency, reputation and expertise within their respective fields. During our existence, and for several years we are also committed with a research and development policy also that is structured in a similar scale than our commercial development, based on three fundamental pillars; production units, sales offices and R+D centers. All those are located in different territories and countries, mainly in EU and the US. As our birthplace is Europe, we strongly maintain and enforce constantly our positioning within the continent. Expansion to Mediterranean Countries, Turkey and influence countries, and Asia, is starting now, at a lengthy pathway. In Europe we maintain permanent offices and allied personnel both to production units as well as sales teams in UK, Spain, The Netherlands, Romania, Poland and Portugal. We are expanding and entering into new markets planning to expand our operations to intensify development in emerging and growing countries. This is the aim behind our compromise to make our business stronger in such territories.

Delivering Quality Through Innovation.

We are growing also forming partnerships worldwide with companies that are renowned in their fields. We are always alert to industrial and commercial opportunities that will help us to continues with this global presence and development.

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Comprehensive R+D+i

Behind every ND Pharma & Biotech product is our comprehensive global research-anddevelopment network.

Global R+D+i Network Online Services and Continuing Support Our code of ethics and higher values of respect, trust and confidence are the true foundation of our action principles. We are concerned to serve, to achieve, to make from your success ours too. Our passion for innovation, research and development, our evolutionary business model, are the basis for a long-term and sustainable growth, and we will be very pleased if these concepts were also yours.

Specifically for our customers, we offer e-ND Pharma that constitutes an ND Pharma & Biotech platform enables customers to cost effectively manage their business with automatic inventory monitoring and ordering, payments, product and ingredient searches, logistics management and reporting. Our informational services provide increasing collaboration and information sharing with suppliers during product research; increases consistent and reliable delivery to meet production demands; expands use and acceptance of electronic trade documents and remittance; and helps integrate companies with trading partners to facilitate cost avoidance. Our personnel, both commercial, technical and back office are available for consultations and problem-solving in an effective manner, with different communication tools from telephone to internet access and many others to make easier the incorporation of our products and developments to your industry and operations, products and client satisfaction.


Academic Institutions

The$ND$Pharma$&$Biotech$Environment$

! Advancing!our!business!across!the!ND!Environment.! ! ! •  ND! Pharma! &! Biotech´s! Company! R+D+I! porAolio! and! the! investment! we´re! making! for! the! near! future! hold! the!potenFal!to!transform!different!sectors!from!Food!&! NutriFon! to! Genomics! or! TherapeuFcs! in! medicine! across! mulFple! drug! modaliFes! and! therapeuFc! areas.! As!the!first!mover!and!leading!company!in!the!space,!our! responsibility! is! to! simultaneously! advance! promising! internal!development!programs,!while!also!mobilizing!an! enFre! environment! capable! of! propelling! the! field! forward! for! paFents,! customers,! consumers,! producers! and!other!agents.!

Industrial Partners

ND Pharma & Biotech Subsidiaries Affiliated Companies

• ! ND!Pharma!&!Biotech!forms!wholly!owned!ventures!to!focus!dedicated!resources! ! an! staff! to! key! areas! within! every! field! and! sector! we´re! operaFng! with! great! ! emphasis!in!those!with!unmet!needs,!and!other!than!demand!safe,!effecFve!and! costNefficient! soluFons.! We! are! incubaFng! addiFonal! ventures! in! diverse! areas,! leveraging!a!crossNsecFon!of!relevant!modaliFes!to!add!to!exisFng!ventures!we´ve! formed!with!key!partners.! •  ND!Pharma!&!Biotech!creates!External!Partnerships!working!with!world!leaders!in! industrial!sectors,!the!commerce!and!other!strategic!alliances!that!may!result!in!a! profound!impact!on!our!business!development!and!the!way!that!our!products!and! innovaFons! reaches! consumer´s! and! can! help! to! improve! people´s! lives.! This! associaFons! are! strengthening! our! possibiliFes! and! augmenFng! our! success! and! impact!beyond!those!fronFers!we!could!reach!on!our!own.! •  This! is! why! we! form! such! associaFons! between! inNhouse! teams! and! partners! to! aRain! the! highest! number! of! developments! possible! and! the! broadest! offer! of! innovaFve!soluFons,!products!and!services!simultaneously,!when!it´s!possible.!To! accomplish! that! goal! we! forge! alliances! and! strategic! partnerships! with! pharmaceuFcal! companies,! industrialists,! governmental! organizaFons! and! research!insFtuFons!from!the!academia,!to!create!a!plaAorm!that!let!us!to!benefit! customers,!consumers,!paFents!and!society!at!large!as!quick!as!possible.!

Corporate$Facts$ Headquarters:!Surrey!and!London,!England,!UK!! LocaFons:!Worldwide!(Mainly!Europe,!North!and!LaFn!America),!Asia!and!Oceania.! Investors:!100%!Private!Company!Limited!by!Shares.! Capital:!+210!M!GBP.! PorAolio!Net!Worth:!+750!M!GBP! !

Contact$$$

Europe$ ndpharmabiotech@europe.com! North$America$ ndpharmabiotech@usa.com! La;n$America$ ndpharmabiotech@samerica.com! Asia$ ndpharmabiotech@asia.com!

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! ! ! !

www.ndpharmabiotech.com!

Commercial Partners

Ventures & Strategic Alliances


WHERE ALL THIS THINGS

OUR COMPROMISE WITH MOTHER NATURE AND SUSTAINABILITY

Quality Through Innovation

Partner of Choice

Innovation is within our nature. It is the way we work, which is why we are able to offer the pharmaceutical and biotech markets advanced technologies that transform life science into new possibilities. We know and recognize that every organization has its own unique needs and such needs are likely to change over time as organizations evolve thoroughly. So throughout our relationship, we innovate, we remain flexible, we adapt and we continue to adjust as goals and objectives may change to reach success.

ND Pharma continues to be the partner of choice for customers looking for an edge in the pharmaceutical and biotech market. Our industry-leading products and services have helped companies of every size, at ever y stage of development increase quality, enhance their manufacturing processes, remove bottlenecks, reduce time to result achievement, improve regulatory compliance, and lower assay and production costs.





…WERE CREATED


OVERVIEW

ND Pharma & Biotech, is a young, recent company within the international market of bio-products and services to pharmaceutical and biotechnology. The Company is set to become one of the leading manufacturers / importers, designers, developers and distributors of the world, with different retail formats result of our constant quest for quality and our passion for innovation, both parameters that has led us to achieve record time series of unparalleled strategic alliances that allow us to place ourselves in the leading position respect to the number of references by area and catalog with over 62,500 references of active and unique products. setting apart the in a short period of time, we have developed the international network and the marketing of products and brands to our different biotechnological production lines have been developed and are among the most productive and profitable sector active . Our special system implementation process, allowing time to respond to record a significant amount of innovation and technological challenges that society demands by operators in different sectors, companies. So, we bond with our customers and partners in an effort to provide and serve the major producers in different sectors as well as small and medium entrepreneurs with their business and concern contribute to the advancement of the industry sharing their problems directly with us and allowing us to help them find solutions that make their products work more simple, natural, healthy, healthy and sustainable. The uniqueness of our business model, based on innovation and flexibility, and achievements have transformed our company into an European and International sector reference. Our understanding of industry, science, technology and life, is summarized in a few lines of expression, creativity, design of products that include a clear commitment to the highest quality and a quick response to the demands of the industry, its needs and market-has resulted in fast international expansion and excellent response to our sales and technology that our company stands by its ideology. The first seed of what is today the company was born from the merger of the innovative zeal of its founder and the needs of an industry with a business model obsolete, outdated processes, little modernization and innovation void, as the market, consumers and industry demanding for sustainability of such a radical change in approach and orientation. From the sea, the first source of life and to the sea, and incomprehensible constant inspiration, was born the seed of our company, where the confluence of the wild seas and the ocean is, solemn and austere with the powerful and immense Atlantic, resulting in England, the green paradise mystical place where the company started business and in which are located the headquarters in/for the UK and the World. GLOBAL COMPANY · GLOBAL SOLUTIONS

We make our business every day bringing innovative thinking to solve the challenges that our customers has to face every day.

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High Quality Ingredients Top Market Brands Our expertise run into multiple applications in Food, Nutrition and Nutritional Health from fortification to infant formulas, dietary supplements, functional, Sports Nutrition, Hospital Nutrition and much more…

ND Pharma & Biotech has made a commitment to give more hope to the life of today and tomorrow. Bringing ingredients, active principles and novel molecules to the different industries and sharing with most of them, (our clients) such commitment, to let themselves to create, manufacture, and deliver the most advanced solutions to worldwide patients and let them to treat and fight against their aggressive conditions and diseases, specifically in the case of cancer. (Oncology), NeuroSciences, Rare and Ultra-Rare Diseases, Food, Nutrition, Agriculture, Fisheries, Pharma, Medical, Healthcare, Research and Development, Innovation, Beverages, Animal Health and a varied number of sectors and fields. We help them to create real innovative solutions that will make the difference, improving genuinely their lives and the life of affected people an promoting excellence in disease prevention and health maintenance. To get these things possible we are embraced in a number of high-profile / top-class investigations and research, focusing on the discovery of novel molecules and therapies designed and engineered for unmet medical and health demands and conditions, including but not limited to certain types of cancer and oncological diseases as solid tumors, like pancreatic cancer, breast cancer and advanced renal cell carcinoma, as well as other hematological/oncological conditions, Alzheimer´s Disease, Schizophrenia, Depression, Multiple Sclerosis, Lateral Amyotrophic Sclerosis, Infections, Tropical Health, Stem Cells, and a multiple-lines of open investigation and innovation. But our mission, do not appear only when the disease is onset and clinically evolved. We are going further back to the point of participate throughout our Food & Nutrition Division, on the most extensive detoxification programs and products (broad consumption), till the point of making possible our vision of removal the chemical – toxic elements and cellular waste deposits present within our body, and coming up from the food and alimentary chain, mean, ingested within foods. In this effort we are praying to get every producer, processor or seller involved with this ideal, that are for us the true reason for living and doing what we do, and every other effort that we should have to do,. By such means we are promoting and cultivating the meaningful spirit of making life better, just making things much better than any others are doing it now. That is the hope for tomorrow that challenges us.


ND PHARMA & BIOTECH

ALL STARTED HERE WITH A TOUCH OF NATURE´S HELP

www.ndpharmabiotech.com


Due to our relationships we can work in close partnerships with our customers so that is the opportunity to get the perfect perspective and deep insight into the challenges that they face day after day. We study, gather and perform a profound analysis of every and all relevant data from multiple systems and inputs, to observe how processes interact and the impact of each one into other, using all this structured knowledge to solve problems and find new horizons, opportunities and business projection within a sustainable environment developing, green, clean, safe and sustainable practices also. ND Pharma & Biotech · Solutions A different type of company in the health & wellness marketplace. ND Pharma & Biotech Company is a discoverer, developer, and marketer of high-quality, scientifically-supported ingredient solutions for the natural products, food & beverage and cosmeceuticals markets, between other sectors. Our goal is to bring innovative and impactful solutions that help our consumer products customers develop new concepts, new products and grow successful brands. An important part of our ability to serve our customers is our network of global strategic partnerships. Our partners are some of the world’s most innovative people, and we help bring them and their companies to market via proprietary ingredient brands with the type of support services that are required by leading consumer product´s companies. This dual role of solution provider to health & wellness consumer companies and commercialization partner for international ingredient suppliers is one of the things that make us unique in the industry. Solutions Targeted to Consumer Demand ND Pharma & Biotech has prided ourselves on our commitment to creativity, integrity and helping our employees, our customers and our partners succeed. Today, we deliver solutions across a number of health & wellness platforms that respond to existing and emerging consumer demand. Delivering these solutions includes marketing over 100 proprietary branded ingredients that are considered either market or scientific leaders in their categories – as well as the supply of high quality botanicals, extracts, raw materials and functional materials that support the development of our customers’ formulated products. Committed to Science, Service & Quality An important part of work for our customers and strategic partners are the committed and qualified people who work at ND Pharma & Biotech and the resources we invest in supporting our solutions in the market. By delivering an unsurpassed mix of expertise, resources, and service, Our company and all we forming it are committed to helping both our strategic partners and valued customers grow.

Patents, Trademarks, Industrial Secrets, Licenses and other IP Rights. The Company holds approximately 500 IP right-protected elements from patent, patent applications, industrial secrets, marks, trademarks and trademark applications, and other IP Rights generator issues from a total documentary repository of +4´5 Million documents. company holds a number of significant trademarks in different fields and sectors from Food & Nutrition to Medical and Healthcare or Pharmaceutical fields. These trademarks are increasing and we developed an actual portfolio of development valued over +750 M€ by creditor agencies and expert research valuation companies, banks and other authorized operating agents.

The Company is aware of the desirability for patent and trademark protection for its products. The Company believes that other than its brand names, no single patent, license or trademark (or related group of patents, licenses or trademarks) is material in relation to its business as a whole. In addition to patents and other existing IP rights, the Company relies on trade secrets and proprietary knowhow. The Company seeks protection of these trade secrets and proprietary know-how, in part, through confidentiality and proprietary information agreements. The Company makes efforts to require its employees, directors, consultants and advisors, outside scientific collaborators and sponsored researchers, other advisors and other individuals and entities to execute confidentiality agreements upon the start of employment, consulting or other contractual relationships with the Company. These agreements provide that all confidential information developed or made known to the individual or entity during the course of the relationship is to be kept confidential and not disclosed to third parties except in specific circumstances. In the case of employees and some other parties, the agreements provide that all inventions conceived by the individual will be the Company's exclusive property. These agreements may not provide meaningful protection for or adequate remedies to protect the Company's technology in the event of unauthorized use or disclosure of information. Furthermore, the Company's trade secrets may otherwise become known to, or be independently developed by, its competitors. Despite this, our Legal and Regulatory department are highly aware of any infringement of such rights pertaining to The Company to execute our legal rights and remedies to its total extent. Competition The markets for the Company's products, services and technologies are both competitive and price sensitive. The Company believes it is a major supplier of biochemical and organic chemical products used in scientific research and testing laboratories, including industrial applications, genomic and proteomic research, biotechnology, pharmaceutical development and as key components in pharmaceutical, diagnostic, environmental and other high technology manufacturing. The Company offers approximately 200,000 chemical, biologic and equipment items, some of which are unique with limited demand including some rare and ultra-rare molecules, active principle´s and other. There are many competitors that offer a narrower range of chemicals and many others offering a broader range of equipment products. In all product areas, the Company competes primarily on the basis of customer service, product availability, quality and price. The Company's main marketing vehicles include its websites starting from the main one www.ndpharmabiotech.com and all derived as well as catalogs both electronically and alternatively printed (The Company maintains a sustainable policy of "paper-free" business), and other marketing materials designed and made on behalf of our existing brands and future developments. These catalogs may be supplemented with advertisements in life science, chemical and other scientific journals and trade publications, the mailing and e-mailing of special product brochures, the electronic distribution of various advertisements and product data, social media, news releases related to new product offerings and through personal visits with customers from management, sales and technical representatives.



Featured Article/Contribution


TIRED OF BEING TIRED?

NEW ROUTES TO FIGHT ANAEMIA

AVIVA

ND Pharma & Biotech ´s Integrated Formula

Iron and Iron Deficiency Conditions


ANAEMIA REVISITED

Anemia aects over of a third of the

8.8% in 2010, but absolute numbers conti-

world's population and accounts for al-

nued to rise, reaching 68.4 million YLDs by

most 10% of years lived with disability

the end of the study period.

(YLD), according to a review of data from 187 nations.

Some positive news emerged from the da-

Despite the ongoing health burden of ane-

ce of severe anemia in women and girls,

mia, the estimated global prevalence decli-

as reported recently in the publication

ned from 40.2% in 1990 to 32.9% in 2010,

“Blood�.

the time frame encompassed by the study. In relative terms, anemia's contribution to YLDs decreased from 11.2% in 1990 to

ta, which showed a decline in the prevalen-

"Targeted anemia surveillance and intervention should be a greater priority in high-risk populations, especially young children and 4


females," the authors concluded. "Despite

grees of anemia severity, and prevalence

causing so much disability, anemia does

by sex.

not receive its requisite attention in many public health spheres including health regulators and authorities in European Countries, Asia or The United States. Such lack of attention may be partly due to anemia being thought of as a byproduct of other disease processes rather than a target for intervention in and of itself." The actual tendency is to imprint within the health specialists, family doctors, nurses and allied personne, and specially policymakers with the basic idea that anemia should be fighted and intervened from early stages to prevent future complications. We try to do this by distilling the heterogeneity of anemia into a single entity while retaining enough information about individual conditions to be able to facilitate formulation of strategies to further reduce anemia burden. Till now, the studies of anemia epidemiology have been limited geographically and in terms of information obtained about etiology and severity. To address those limitations, certain solvent research groups analyzed publicly available data from 187 countries and estimated the total prevalence of anemia, prevalence of dierent de-

Using information from the Global Burden of Diseases, Injuries, and Risk Factors Study 2010, investigators determined cause-specific attribution of 17 dierent conditions associated with anemia. The analysis showed an overall increase in anemia-related YLDs, but anemia prevalence decreased in both sexes and in all levels of severity. Among males (all ages), the prevalence of mild and moderate anemia decreased substantially, whereas prevalence of severe anemia declined the most in females. The large decrease in severe anemia in females resulted in almost a 5% decline in the average severity of anemia, as compared with an increase of 1.5% in males. Geographically, South Asia accounted for the largest share of global anemia YLDs throughout the study period, so the share declined from 39.8% in 1990 to 37.5% in 2010. Analysis of cause-specific anemia burden showed that iron deficiency was the leading cause in males and females during the entire study period. Five other conditions followed in terms of contribution to overall burden at all times: hookworm, 5


ND# Pharma# &# Biotech# is# a# biopharmaceu4cal# and# chemical# company#

focused#on#the#rapid#development#of#industry#solu4ons#for#diverse#fields#and# sectors# from# healthcare,# medicine,# food# &# nutri4on,# agriculture# and# other# resources.#As#a#leading#company#we#have#developed#an#immense#porAolio#of# innova4ve# solu4ons# from# our# highBprofile/highBevolved# Research# +# Development#+#Innova4on#sec4on,#well#balanced#with#our#diverse#porAolio#of# commercialized#products#and#services.# # The$Group´s$industrial$and$marke4ng$ac4vi4es$is$supported$by$a$global$network$ of$sales$representa4ves$with$interna4onal$presence$in$different$con4nents$and$ countries.$ Our$ opera4ons$ comprise$ produc4on,$ marke4ng$ and$ commercializa4on$worldwide$with$a$strong$focus$in$new$developments.$ Global#presence#

Pro#forma#–#Key#numbers#

€258M$$ Capital$

€0$$$ Debt$with$creditors/financial$

300%$$

Net$sustained$sales$growth$2012$

€750M$$

Es4mated$value$R+D$PorTolio$

500%$$

Average$planned$growth$by$sectors.$

$

We$ contribute$ to$ the$ success$ of$ our$ customers$ in$ nearly$ all$ sectors$ and$ almost$ every$ country$ in$ the$ world.$ We$ maintain$ a$ broad$ porTolio$ arranged$in$different$sectors$from$Chemicals$to$Pharmaceu4cal,$Personal$Care,$Performance,$Func4onal$Materials,$On^field$Solu4ons,$etc.$We$ are$ self^finance,$ stable$ and$ private^owned/managed$ company$ with$ an$ impressive$ record$ of$ research,$ development$ and$ innova4on$ and$ registra4on$of$IP$rights$since$the$founda4on$of$the$company.$ND$Pharma$&$Biotech$operates$worldwide$thru$a$network$of$distribu4on$partners.$ API´s# BIOCHEMICALS# MOLECULES## PHARMACEUTICAL# HEALTHCARE# MEDICAL# BIOTECHNOLOG# RESEARCH# FOOD#&#NUTRITION# COSMETICS# BRANDING# BIOLOGY# ECOLOGY# SUSTAINABILITY# REGULATION# LEGISLATION# CHEMICALS# BIOCHEMICALS# INDUSTRIAL# CONSUMER# WASTE#MANAGEMENT# PERSONALIZED#SOLUTIONS# DEVELOPMENTS# RESEARCH## INNOVATION# IMPLEMENTATION# PROCESSING# AUDIIT# COMMERCIAL# SUPPLY# DISCOVERY#

+450$Basic$Product$References$(TRADING

)$

+62.500$References$Fine$Chemicals$&$Industrials +150.000$NCE´s$Novel$Chemical$En44es$and$Building$Block$Molecules $

$

+$32$Own$Brands$in$Food$&$Nutri4on$Division

$

+21$Brands$of$single^family$PRESERFOOD$TM +$6$Brands$of$Agri^business

$

$

+$23$Brands$of$Pharmacy$&$OTC$products +$9$$Consumer$Brands$(4$Water/3Specials/3Industrial) +$15$Lines$of$Non^Controversial$STEM$CELLS $

$

$

Contact##Us#

Commercial#

Disclaimer#

ND#Pharma#&#Biotech# Registered$Address$ Surrey,$England,$UK$

Europe,#Middle#East#&#Africa#

This$fact$sheet$has$been$prepared$at$August,2014$This$document$should$not$create$ any$implica4on$that$there$has$not$been$any$change$to$the$business$or$affairs$of$ND$ Pharma$&$Biotech$Co.,$or$that$the$informa4on$contained$herein$is$correct$as$at$any$ 4me$ subsequent$ to$ its$ date.$ The$ Pro^Forma$ and$ financial$ informa4on$ has$ been$ extracted$ from$ our$ records$ and$ exis4ng$ reports$ from$ our$ bankers,$ investment$ operators$ and$ financial$ advisors,$ including$ the$ applica4on$ of$ The$ Valua4on$ Guidelines$for$Technological$&$Scien4fic$Companies$applied$by$investment$bankers.$ $ Any$issue$regarding$informa4on$contained$herein,$please$refer$in$write$to:$$ cfo@ndpharmabiotech.com0

#

$

ceo@ndpharmabiotech.com0 $

General#Informa4on# info@ndpharmabiotech.com$

#

ndpharmabiotech@europe.com0 $

The#Americas#

ndpharmabiotech@usa.com0 $

AsiaBPacific#&#Oceania#

ndpharmabiotech@asia.com0

$

#


sickle-cell disorders, thalassemias, schisto-

Though global in nature, the results are re-

somiasis, and malaria. The contributions of

levant to North America an Europe, as it

malaria, schistosomiasis, and chronic

seems that anemia in children is less of a

kidney disease (CKD) were the only condi-

problem as compared with developing

tions that had increasing burdens of ane-

countries, but affects older individuals mo-

mia.

re often.

North America had the lowest anemia bur-

In other hand, there are anemias associa-

den attributable to iron deficiency (3%),

ted to other medical and health conditions

whereas other regions had dramatically

that are in need of being revisited as well.

higher rates: Central Asia (64.7%), South

Patients undergoing dialysis and chemo-

Asia (54.8%), and Andean Latin American

therapy may have very different experien-

(62.3%). High-income areas had larger con-

ces, but many share one thing in common:

tributions from hemoglobinopathies, CKD,

anemia.

and gastrointestinal hemorrhage.

Kidney disease often compromises the pro-

Globally, the postnatal period had the

duction of red blood cells, while chemothe-

highest anemia prevalence, followed by

rapy can damage blood cell-forming

children 1 to 4 years. The same age

tissues within bone marrow. Anemia often

groups had the least favorable changes in

weakens, and further compromises these

epidemiology during the study period. Ane-

patients. Current treatments are expensi-

mia associated with CKD increased with

ve, involve frequent dosing, and can have

age in both sexes, topping out among

detrimental side effects.

adults 80 and older.

ND Pharma & Biotech Co. is exploring how

From age 15 through adulthood, females

bone marrow generates new red blood

consistently had higher rates of anemia. Fe-

cells, and how new anemia treatments

males also had the highest disability

might be developed for dialysis and cancer

weights throughout the study period.

patients, from stem Cells to alternative Iron

One of the key messages from this publica-

Absorption Metabolic Routes.

tion is that anemia, while we recognize as

A team of scientists dedicated to unders-

common across different populations and

tanding how stem cells develop into

ages, still tends to be overlooked.

tissues and organs, how they respond to 6



injury, and how they can be used for medical treatments. Developments made has received international attention for his efforts to discover new ways to stimulate the production of red blood cells in these patients. Our Scientific Office hold certain discoveries that are uncovering new molecules which prompt red blood cell development. We firmly believe that once we will understand the many ways that the body converts bone marrow to red blood cells, we should then be able to trigger this process via new approaches with fewer or none side effects.

ition

s!

A V I AV

and Iron

ND

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Iron

ond cy C n e i fic

De

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´s ech Biot

u Form ted a r g Inte

ician/ phys your ative m ed by ern mend ry of alt igestion m co ve d isco asy be re n may rch and d ty and e h iro d wit ns it a bili nditio d on rese bioavaila mpare d variable fic co re co f e speci ct is bas r level o 25% mo certain an list. Or a r e d e a u n n d h d ci and u This pro nded hig lacebo an ber of u er or spe cases ion rld. num rete np some in the wo t with a p more tha er by a lth practit e. In r ie oth ea on-fre r regulato to the d to a 45% ual to an family h ti ip r up ents cy o rescr you divid TC) p any agen cific elem consumers m one in e consult y o s pe f ent (O plem aluated b of such s e levels o ay vary fr IVATM plea ulas. v l sup F itiona ot been e a supply ease in Results m use of AV pecific form tr u n n s is e a e. incr . It´s A TM has uct intake relative iron intak about th ithin their drug t w a IV d not a arding AV o the pro s shown actions to any doub gredients TM a is is s AVIVAormula. Th ments reg cessities, d studies h general reu may have AVIVA TM in t u o e te f ab ient´s F tc.. Sta lated n ts an fort and etc. If yo ration o ation d re o m , al tes r, e infor matural Ingrenal adviso nutrient´s cers. Clinic astric disco of anemia the incorp g N n m io r tant g Impo TM 100% titian/nutrit eme-buildin rption enha curve in ases, natureuct or fro e A h e ie o s AVIV acist/ d m and abs decrea take, dis this prod l ra f lis tu a pharm n metabo in na nts with tments in the use o a e certa of iro help of supplem drug/tre enefit with b er nd the with rations a itions, oth could be t a d a p n pre ying co ions th it rl unde ing cond rd rega

7


Alternative Anemia Routes Unmasked

Anemia is the general name of a broad

could trigger any failure in the process of

group of diseases characterized by the

red blood cell building, or working, can

occurrence of some problem in the func-

lead to some problem in oxygen transport.

tion of red blood cells to take, transport, or delivery oxygen, from the lungs to the tissues. It may to have dierent many origins, changing in complexity and factors, predisposing conditions, agents interacting and a several impliactions both endogenous as well as exogenous, as in the case of poor diet habits, malnutrition, or certain pre-existing medical conditions that

Our research was performed within a 2 years period with 235 participants included 103 who suered from some kind of anemia, with ferropenic anemia (iron deficiency) being the most frequent. Proposed formulation treatment was a composition of amino-acids, mineral salts and peptides, discovered as sequentiators 9


of primary, secondary and tertiary routes of

ments are difficult to obtain to be used for

iron absorption-conversion not competing

the mentioned processes as are also criti-

with other natural elements in heme crea-

cal to maintain other relevant-to-health me-

tion of development.

tabolism tasks within the organism.

Treatment by supplementation of such na-

We´have also identified the specific num-

tural composition was observed as effecti-

ber and class of molecules that are spent

ve in all these cases.

to build one heme.

Specifically for certain types of anemia

Hemoglobin, very abundant protein in the

which are due to iron deficiency could mo-

body represents up to the 90% of the

re accurately be identified as an incompe-

dried weight of the red blood cells (around

tence of maintaining the role of certain ami-

2χ1012 cells in the body of an average

no-acids and their metabolic pathways,

adult).

that were largely ignored during years, but revealed substantial to elevate the iron absorption-conversion improvement without the employment of iron supplemets that may cause a number of undesirable side effects. Additionaly, body iron deposits should be re-adjusted from time to time, to adapt to the iron supplementation, so this processes of re-adaption are energy consuming and plenty of metabolic damages due to the bio-deterioration caused by

Moreover, hemoglobin turnover is short (120 days) and there is no recycling of material, as the heme group is destroyed to bile pigments. Blood building is, thus, a high expenditure such elements, and therefore deficiency of such is a resulting factor of metabolism expenditures that is being identified also as the principal probable cause of anemia or at least the principal cause that human body can not resolve

supplemental iron within cells and tissues.

iron deposits deficiencies and depletion (in-

We´ve shown that the the structures of he-

the anemic status.

cluding absorption and fixation) leading to

me (the prosthetic group of hemoglobin) and porphobilinogen (the basic intermediate in heme building), utilize certian elements associated to the production processes that we´ve identified. Such ele-

10


Our discovery and invention, as part of the developed process Discovery of a nutritional supplement with capacity of restore and supply elements employed in heme building, iron depletion control, absorption and fixation, is an issue of enormous importance and undoubted commercial interest.

ND Pharma & Biotech is willing to help in a natural, safe and effective way to all those people affected by such conditions and suffering the impact of anemiadependant health problems.

and related formulas, relates to a food-supplement or pharmaceutical-nutritional (nutraceutical) composition suitable for the treatment of anaemia conditions, from dierent origins and causes, since the result of iron deficiencies are remaining common to all such causes. As it has been stated, common therapeutic treatments are based on the administration of iron supplements such as, in particular, ferrous sulphate, or alternative organic Fe associated to pretended substances that may promote absortion and/or fixation. The vast majority of such substances show a poor gradient of bio-availability with more-than-questionnable therapeutic eect rquiring with prolonged treatments another measures taken in order to re-establish the organism's iron reserves.

11


Prolonged administration of ferrous sulpha-

elements needed in these actions and in-

te which constitutes the standard drug of

creasing iron bioavailability thru the action

reference, however, causes side effects

of bioavailability enhancers, under our pro-

such as gastrointestinal disorders, gastric

prietary methods of technology and pro-

irritation, cramps and diarrhoea whi-

duction processes.

ch—when they arise—require a substantial reduction of the dosages.

The present invention is based on the dis-

Principal barrier to achieve better results is

achieved throughout the administration of

due to the low rate of iron absorption by

a certain compositions and formulas crea-

the organism, which is of the order of

ting in a natural, safe and effective way,

approximately only 5-15% of the ironadmi-

the necesary environment to apport to hu-

nistered.

man metabolism routes the necessary ele-

This is why research relating to anti-anaemic agents for the treatment of anaemia caused by iron deficiency have been direc-

covery of the fact that such goal can be

ments in the best available structure with an unparalelled analogy to the human synthesized molecules.

ted mainly towards the identification of pre-

The composition has been found suitable

parations which can improve the solubility

for promoting the absorption both of iron

of iron with the use of pharmaceutical addi-

which is naturally present in foods and of

tives which improve its solubility by for-

iron which is administered even as a

ming complex salts with iron, and agents

supplement in diets that are poor in iron or

such as reducing agents which can pre-

as a drug in the treatment of anaemia, in-

vent oxidation of ferrous ironto ferric iron.

cluding certain types EPO resistant.

The most recent trends initiated by our

During the period of treatment the patients

company (Stem Cells aside) points out that

were required to maintain a normal diet

the better way to fight such circumstances

which was confirmed not to be lacking in

regarding to iron metabolism, are passing

iron. Upon completion of the treatment, all

thru do not provide iron as such, and pro-

the patients under test had sideraemia va-

moting instead the alternative metabolic

lues greatly above the threshold value.

routes to do not exhaust or release iron deposits and reserves supplementing other

12


Certain foods are exposed to pesticides and insecticides from crop to the table. Insecticides are life-threatening compounds that imply significant risks for human health and consumers well-being. Even terms like “organic” does not mean that such labelled foods are pesticide and/or insecticide-free. If you´re concerned with this matter, that is killing people all around-the-world, you should take action and ask from producers, processors and regulators strict measures and ethical behavior to protect human beings before economic interests. Now, there are Eco-Friendly systems and products providing crop protection and pesticide/insecticide-free processing for certain foodstuffs, including cereals, vegetables, fruits, and many other extracted from agriculture like rice, corn, nuts, flour, etc. Welcome to the next generation pesticide/insecticide-free and naturally protected foods

Welcome to ACARISINTM 100% NATURAL- MINERAL ECO-FRIENDLY SOLUTION FOR PEST CONTROL AND HUMAN HEALTH PROTECTION


a e i e spati of us erent releas ly cha d the n diff ypes supp reby n t o e a e t h d h n s t e w t e s n s differ tion in se ba artme roces nt the of a u collec the p comp u s a l o is t a ic c a t t n c d n is io e er into a le for timat ironm aract se es cessib taking g env he ch c t l, a in l a e iv it ic Relea e b c ke em nd re RCs la d ma f a ch ed. E ays a ion an p t ges o w a lo h t e a v im st de ion p ase e been emiss tive. e rele have h t ) s e rspec C n e li R p E m l ( a a s t stre gorie nmen e cate enviro s a m le o r e f r nt releva pects

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REACH/ECHA is the EU chemicals legislation dealing with the Registration, Evaluation,Authorization and Restriction of Chemicals which entered into force on 1st June 2007. REACH covers chemical substances as such, in preparations or in articles intended to be released. The regulation replaces numerous EU laws and is complementary to other Environmental and Safety legislation.

www.ndpharmabiotech.com

19


The ND Pharma & Biotech Company Limited Great Bookham, Surrey, England, UK _______________ info@ndpharmabiotech.com www.ndpharmabiotech.com

ND P&B The MAGAZINE


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