A reliable alternative to natural CBD

With Canapure, Symrise is setting new standards in the synthetic production of CBD. This nature-identical and especially pure cannabidiol is produced according to the quality standards of GMP.

Originally launched at CPhI Worldwide in November 2019, Canapure by Symrise is suitable for the same applications as natural cannabidiol (CBD). This is thanks to a production method developed to deliver a nature-identical cannabinoid, which Symrise expects will revolutionize the pharmaceutical industry.

With Canapure (cannabidiol), the pharmaceutical industry now has access to a nature-identical, synthetically produced CBD that is both a valuable active pharmaceutical ingredient and an intermediate product for the development of new substances. Scientific studies prove that the nature-identical active ingredient is identical to CBD derived from the cannabis plant. At the same time, the Symriseproduct achieves a purity level of 99.8%.

STUDY RESULTS CONFIRM MATCHING PROPERTIES

Canapure is identical to natural CBD, which does not have psychoactive effects. It is said to have relaxing and anticonvulsive, anti-inflammatory, anxiety-relieving and nausea-relieving effects. THC derivatives are not detectable in this synthetic active ingredient.

A joint comparison study by the Universities of Madrid and Córdoba and specialised institutes in Spain and Germany confirms that analytics have found no significant difference in the biological value of purely natural CBD and natureidenticalCanapure. In addition, an X-ray structure analysis by the Max PlanckInstitute proves that the absolute configuration of Canapure matches that of CBD.

“With Canapure, we are offering a reliable alternative to natural CBD,” says Jörg ThiloFischer, technical manager API at Symrise.“This product innovation is identical to natural CBD, of consistently high quality and purity and available all year round.”

Scientific studies prove that the nature identical active ingredient is identical to CBD derived from the cannabis plant

ACTIVE INGREDIENT BASED ON D-LIMONENE

In the production of Canapure, Symrise uses its expertise as the world’s leading expert for fragrances and flavorings made from terpenes. D-limonene, the basis for the active ingredient, belongs to the group of terpenes. This renewable raw material is a by-product of the orange juice market. It comes from the peelsof the fruit. Symrise converts the D-limonene to menthadienol, which is ultimately used to produce Canapure.

Symrise has developed the synthetic CBD according to the guidelines of good manufacturing practice (GMP) for active ingredients for the pharmaceutical industry. Accordingly, both the source materials and Canapure are produced under GMP conditions. This means that the processes comply with the particularly strict requirements for all manufacturing practices such as materials, equipment and hygiene.

“During production, we place great importance on sustainability and GMP-compliant quality management,” Fischer comments. “In this way, we conserve resources while meeting the high demands of our customers.” •

Symrise – www.symrise.com