Risk factors for dementia The Lancet Commission presents a new life-course model showing potentially modifiable, and non-modifiable, risk factors for dementia.
th Bir
7%
ApoE Îľ4 allele
%
Percentage reduction in new cases of dementia if this risk is eliminated
fe rly li Ea
8% 8%
5%
Less education Less education
ife idl M
Hearing lossloss Hearing 9%
Hypertension 2% Hypertension Obesity 1% Obesity
3%
Smoking Smoking
Depression Depression
Physical inactivity Physical inactivity
e life Lat
5% 4%
Low social contact isolation 2% Social 1% Diabetes Diabetes
Potentially Potentially modifiable modifiable 35% 35%
Potentially Potentially non-modifiable non-modifiable 65% 65%
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