Chapter 03: Immunity and Immunologic Oral Lesions Ibsen: Oral Pathology for the Dental Hygienist, 7th Edition MULTIPLE CHOICE 1. The breakdown of cellular adhesion between epithelial cells is termed a. cell-mediated immunity. b. acantholysis. c. Nikolsky sign. d. anaphylaxis. ANS: B
Acantholysis is the dissolution of the intracellular bridges of the prickle cell layer of epithelium. Cell-mediated immunity is immunity in which the predominant role is played by T-lymphocytes. Nikolsky sign occurs when the superficial epithelium separates easily from the basal layer on exertion of firm, sliding, manual pressure. Anaphylaxis is a severe type of systemic hypersensitivity reaction. REF: Pemphigus, page 101
OBJ: 1
2. Which protein molecule is produced by plasma cells and is also termed an immunoglobulin? a. An autoimmune disease b. A natural killer (NK) cell c. Rheumatoid factor d. An antibody ANS: D
An antibody is a protein molecule, also called an immunoglobulin, that is produced by plasma cells and reacts with a specific antigen. An autoimmune disease is a disease characterized by tissue injury caused by a humoral or cell-mediated response against constituents of the body’s own tissues. An NK cell is a lymphocyte that is part of the body’s innate immunity. Rheumatoid factor is a protein, immunoglobulin M (IgM), found in serum and detected in laboratory tests. It is associated with rheumatoid arthritis and other autoimmune diseases. REF: Vocabulary, page 79 | B-cell Lymphocyte, page 81
OBJ: 1
3. Which lymphocyte matures without passing through the thymus and later can develop into a
plasma cell that produces antibodies? a. T-lymphocyte b. B-lymphocyte c. Macrophage d. LE cell ANS: B
The B-lymphocyte matures without passing through the thymus and later can develop into a plasma cell that produces antibodies. The T-lymphocyte matures in the thymus before migrating to tissues. A macrophage is a large tissue-bound mononuclear phagocyte derived from monocytes circulating in the blood. The LE cell is an atypical mature neutrophil characteristic of lupus erythematosus and other autoimmune diseases.
