GSK Montrose Primary Manufacturing & Supply Excellence, Partnership, Passion
An introduction to GSK Montrose primary supply facility
GlaxoSmithKlines’ Montrose site is a primary supply facility and a key provider of active pharmaceutical ingredients (APIs) for some of GSK’s most therapeutically and commercially important products. Operating since 1952, the 45 acre site is situated on the east coast of Scotland, approximately mid-way between Dundee and Aberdeen. Key capabilities A lean manufacturing facility, Montrose is a key supplier of APIs for GSK’s largest-selling respiratory portfolio; for a number of steroid products and for a range of other treatments including influenza, high blood pressure, benign prostatic hyperplasia and AIDS/HIV. The site has a long association with products used to treat asthma and COPD (chronic obstructive pulmonary disease), which includes extensive expertise in physical properties characterisation, a critical aspect of respiratory products. Montrose also has a long history of supplying actives for steroids, manufacture of which involves complex, multi-stage synthesis. Manufacturing facilities have state of the art control systems and are highly contained. Production can be accommodated in either dedicated plant or in general-purpose, multi-stream facilities which are flexible and can be turned around quickly.
‘Making Montrose Memorable’
Site capabilities range from large-scale, highly automated manufacturing to smaller-scale specialist production enabling greater ‘hands on’ attention. Over £50 million has been invested recently upgrading plant and renewing infrastructure enabling the site to meet GSK’s exacting standards and to offer its vast experience and modern manufacturing capabilities to thirdparty clients. The site has a proud record of satisfying the requirements of all of its regulators, both in terms of product quality and environment, health and safety performance. Regulators include the US Food and Drug Administration, the UK Medicines and Healthcare products Regulatory Agency, a number of international licensing authorities and the Scottish Environment Protection Agency.
‘Making Montrose Memorable’
People at Montrose Staff at Montrose are highly skilled and adaptable and work in integrated teams. Continuous learning and personal development are embedded in the site’s culture, as are continuous improvement and operational excellence best practices. With lean manufacturing and six sigma established for many years, performance management is in the site’s DNA and daily performance tracking is both highly visual and participative.
‘Making Montrose Memorable’
Products and markets Montrose supplies active ingredients for products used by millions of people every day around the globe. The site is a key supplier for GSK’s highly-successful respiratory portfolio, which annually generates international sales worth £5 billion. Montrose also supports GSK’s growing dermatological business and has extensive expertise in complex manufacturing processes to produce steroidal APIs used in topical end products. Montrose APIs are used in end products supplied to many European Union countries and to internal markets, including the USA and Japan. Fluticasone Propionate
Dutasteride
Market name; Flixotide, Flovent, Seretide and Advair, for the treatment of Asthma, allergic rhinitis, eczema and psoriasis.
Market name; Avodart, for the treatment of benign prostatic hyperplasia
Salbutamol Sulphate
Zanamivir
Market name; Ventolin, for the tratment and relief of Asthma, chronic obstructive pulmonary disease.
Market name; Relenza, for the treatment of Influenza.
Betamethasone Valerate
Lacidipine
Market name; Betnovate for the treatment of Skin diseases including eczema and psoriasis.
Market name; Lacipil, for the treatment of high blood pressure.
Clobetasone Butyrate
Abacivir Sulfate
Market name; Eumovate, for the treatment of Eczema and chronic dermatitis.
Market names; Zaigen, Kivexa, Trivizir, for the treatment of AIDS and HIV.
Clobetasol Propionate Market name; Dermovate, for the treatment of skin diseases including eczema and psoriasis
‘Making Montrose Memorable’
GlaxoSmithKline Cobden Street Montrose Angus DD10 8EA Scotland Tel: 01674 672606 Fax: 01674 666688 Email: UK-SiteMontrose@gsk.com www.gsk.com