Humans, Animals and Covid19: a two-way street (or roundabout?) By Mike Fitzgerald,
Veterinarian, Alstonville. As I write this the total number of confirmed cases of SARS-CoV-2 / Covid19 in the species Homo sapiens sapiens is 66,868,965, with 1,430,389 deaths. Given a global population of 7.8 billion, that’s approximately one death per 5,500 people. Ours is not the only species susceptible to infection with Covid-19. This article attempts to describe what that might mean for us and for other species. Just as the dromedary camel was susceptible to MERS, some other mammal species have structurally similar binding sites for Covid19 (aka SARS-CoV-2). These are primarily the angiotensin-converting enzyme 2 (ACE-2) receptors in the lungs, to which the SARS-CoV-2 spike proteins attach. Similar binding sites means that these species can potentially be infected with it. (Although fewer of these mammal species are similarly affected by it due to different host immune responses.) The consequences of this fact have several aspects: Firstly, there’s the risk of zoonotic (animal to human) spill-over from an intermediate host, as was recently seen in Denmark with a dozen human cases of infection with a Mink mutation variant of SARS-CoV-2. Secondly, there’s the risk of human to animal transmission to a susceptible species, some of which are endangered. The Leakey Foundation has warned of the potential risk of SARS-CoV-2 to non-human primate species in zoos, research facilities and most importantly in endangered wild populations. Apes and all African and Asian monkeys are identical to humans at all of the binding sites, so they are likely as susceptible to SARS-CoV-2 as humans are. Some of these critical primate species number in the thousands and could face extinction if infected. Thirdly, there is the risk of the establishment of reservoirs of SARS-CoV-2 infected species in the wild. This could make future control and elimination of the
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American Mink - White by felixd, CC BY-SA 4.0, via Wikimedia Commons virus from human populations difficult. A species called Neovison vison, the European farmed Mink, hasn’t fared that well. Mink are carnivorous semi-aquatic members of the mustelid family, which also includes otters, ferrets and weasels. They are farmed intensively for their fur in Northern Europe, North America, Ireland and Russia. Mating occurs in March, and after a life spent in cages under controlled lighting, those not needed for next season’s breeding are killed by gassing with carbon monoxide about nine months later for their pelts - so that we can exercise our Godgiven right to look like a 1930s bootlegging mobster or Marilyn Monroe in Gentleman Prefer Blondes. (Memo to H. sapiens: “we can do better”). In September 2020, in Jutland Denmark 12 human cases Covid19 were found to be caused by a mink-derived variant of SARS CoV-2. This variant was colourfully named the “Cluster 5” mutation. The cases ranged from ages 7 to 79, with all having links to the mink farming industry. The Danish authorities were concerned that this had potentially serious implications for diagnostics, therapeutics and vaccines. On November 5 the Danish Government ordered that all Danish mink must be
culled (i.e. gassed en-masse and bulldozed into mass graves), a total of 17 million, give or take. A political storm ensued, which ultimately led to the resignation of Denmark’s Agriculture Minister, largely over the fact that there was no legislative basis for the decision. So far, the “Cluster 5” mink Covid19 mutation has not proved dangerous and seems to be a dead-end in people because it hasn’t spread. However, it caused concern because variations in the virus spikeprotein region could affect the immune system’s ability to detect the infection. Many vaccines also train the immune system to block the spike protein. The end-result was that the 17 million dead mink were collateral damage. [Sickeningly, many culled mink were soon ‘rising from the grave’, as their gas bloated bodies caused the shallow burial pits to burst from the ground https://www. theguardian.com/world/2020/nov/25/ culled-mink-rise-from-the-dead-denmarkcoronavirus] Carl Linnaeus named our species Homo sapiens in 1758 (from Latin, sapiens the wise). Alternatives might be Homo hubris, Homo imprudentis or Homo arrogans. It is probably too early to tell which is the most suited.
