ABBREVIATIONS

8 

ACGIH® American Conference of Governmental Industrial Hygienists ADI Acceptable Daily Intake ADME Adsorption, Distribution, Metabolism, Excretion ANSES French Agency for Food, Occupational and Environmental Health & Safety AOP Adverse Outcome Pathways AOP-KB Adverse Outcome Pathway Knowledge Base

Assessment value

Can be a health, risk, statistically or technically derived assessment value to be used biomonitoring, see OBL, POBL, ROBL or TOBL ATSDR Agency for Toxic Substances and Disease Registry BAR Biological Reference values, Biologische Arbeitsstoff Referenzwerte BAT Biological tolerance values in blood and urine, Biologische Arbeitsstoff-Toleranzwerte BBLV Binding Biological Limit Value BE Biomonitoring Equivalent BEI Biological Exposure Indices BGV Biological Guidance Value BLV* Biological limit value BLW Biological guidance value, Biologische Leitwerte BM Biomonitoring BME Biomarker of Exposure BMDL Benchmark Dose Lower Confidence Limit BMGV Biomonitoring Guidance Value BOELV Binding Occupational Exposure Limit Value BRV Biological Reference Value CAD Chemical Agents Directive CMD Carcinogenic and Mutagenic Directive DEHP Bis(2-ethylhexyl) phthalate or di(2-ethylhexyl) phthalate DNEL Derived No-Effect Level DNELbiomarker Derived No Effect Levels expressed as internal concentrations

DNT Developmental Neurotoxicity EC European Commission ECHA European Chemicals Agency

EGMAST Extended Advisory Group on Molecular Screening and Toxicogenomics EKA Exposure equivalents for carcinogenic agents, Expositionsäquivalente für krebserzeugende Arbeitsstoffe EQ* Equivalent concentration ESFA European Food Safety Authority EU European Union FUE a steady-state concentration factor for urine measured after 24h or 48h exposure HBM GV Human Biomonitoring Guidance Values HBM4EU European Human Biomonitoring Initiative IOELV Indicative Occupational Exposure Limit Value HDA Hexamethylendiamine

OCCUPATIONAL BIOMONITORING GUIDANCE DOCUMENT © OECD 2022

 9

HDI Hexamethylendiisocyanat ISES International Society for Exposure Science ISO International Organization for Standardization IUCLID International Uniform Chemical Information Database KE Key Event KER Key Event Relationship LOAEC Lowest Observed Adverse Effect Concentration LOAEL Lowest Observed Adverse Effect Level LoC Level of Confidence MAK* Maximum workplace concentration or Maximale Arbeitsplatz Konzentration MIE Molecular Initiating Event MoA Mode of Action NCO group functional group of isocyanates NIOSH National Institute for Occupational Safety & Health NOAEL No-Observed-Adverse-Effect-Level OECD Organisation for Economic Co-operation and Development OBL Occupational Biomonitoring Level OBEL Occupational Biomonitoring Effect Level OEL Occupational Exposure Limit OELV Occupational Exposure Limit Value OHP Occupational Health or Hygiene Professionals OSH Occupational Safety and Health PARC European Partnership for the Assessment of Risks from Chemicals

PBD modelling

Physiologically Based Dynamic modelling

PBK modelling

Physiologically Based Kinetic modelling POBL Provisional Occupational Biomonitoring Level POBEL Provisional Occupational Biomonitoring Effect Level PoD Point of Departure PPE Personal Protective Equipment RAC Risk Assessment Committee, European Chemicals Agency REACH Registration, Evaluation, Authorisation and Restriction of Chemicals RfD Reference Dose ROBL Reference Occupational Biomonitoring Level ROBEL Reference Occupational Biomonitoring Effect Level RMM Risk Management Measure SCOEL Scientific Committee on Occupational Exposure Limits SEG Similar Exposure Group SUVA Swiss National Accident Insurance Fund TDI Total Daily Intake

TLV®

Threshold Limit Value, level to which a worker can be exposed day after day for a working lifetime without adverse effects TOBL Technical Occupational Biomonitoring Level TOBEL Technical Occupational Biomonitoring Effect Level TRV Toxicity Reference Value TWA Time Weighted Average WHO World Health Organisation WPEA Working Party on Exposure Assessment WPHA Working Party on Hazard Assessment

OCCUPATIONAL BIOMONITORING GUIDANCE DOCUMENT © OECD 2022