William G. Lowrie Department of Chemical and Biomolecular Engineering 2017 A N N U A L R E P O R T
Breakthrough developments in chemical looping
New technology has major implications for the energy industry
PLUS: • Six new faculty join department • Worldwide attention for Jim Lee’s regenerative medicine innovation • Barbara Wyslouzil sets world record for most cubic ice • Nicholas Brunelli and Jacob Elmer win 2017 NSF CAREER Awards
Message from the Chair Hello from the William G. Lowrie Department of Chemical and Biomolecular Engineering! Following up on 2016’s successul recruiting of new faculty members Li-Chiang Lin, Ilham El-Monier, and Katelyn Swindle-Reilly, we’re thrilled to welcome 2017’s new faculty -- Eduardo Reátegui, Andrew Maxson, and Andrew Tong, who all bring exceptional skills to the department. In addition, for 2018-20 we are excited to have just hired Joel Paulson, Xiaoxue Wang, and Xiaoguang Wang. Details coming soon! Here in the department, faculty continue to make important discoveries and innovations. After 40 years of research, L.-S. Fan’s breakthrough development of a highly durable particle takes his chemical looping processes into the next realm of efficiency, creating opportunities for industry to capitalize on cost-efficient clean energy. In the biotech area, Jim Lee’s amazing innovation - the ‘one-touch-healing nanochip’ - shows tremendous promise in healing damaged tissue simply and efficaciously. And Barbara Wyslouzil has created the world’s most cubic ice, which could facilitate climate studies and deepen our understanding of one of the world’s most important resources - water. The ranking of our graduate program in the 2019 U.S. News and World Report is currently #26, up from #29 in 2014, and research expenditures are holding steady at around $8M. I hope you enjoy getting caught up on more news in the pages that follow. Wishing you a great 2018!
Andre Palmer Professor and Chair
INDEX 1. Mission and Key Facts
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2. Faculty News 6-12 L.-S. Fan’s Materials Breakthrough 6-7 James Lee: One-touch Healing 8 Barbara Wyslouzil: Cubic Ice 9 Faculty Awards 10-11 New faculty Reátegui, Maxson, Tong 12
Ohio State University researchers at work testing Dr. L.-S. Fan’s chemical looping processes. Fan’s 40 years of research have resulted in breakthrough advances in efficient chemical looping technology that could have major implications for the energy industry.
3. 2017 Research Program Research Highlights
13-15 14-15
4. Faculty Activity Summaries
16-33
5. Graduate Program GRS Keynote Mahesh Kumthekar
34-35 35
6. Undergraduate Program 36-37 Charles Fryer’s Successful Research 37 7. Alumni News Alumni Win Awards Jacob Elmer’s NSF CAREER Award
38-39 38 39
8. Charitable Giving Scholarships
40-42 40
10. Faculty / Staff Listing
43
The cover image depicting L.-S. Fan’s chemical looping process appeared on the back cover of Energy & Environmental Science, 10, 23182323 (2017). Used by permission. Background photo on this page by Eric Collins, 2016.
Professor Liang-Shih Fan (yellow hard hat) and team.
2017 Annual Report writing, design, and layout by Wenda Williamson, email: williamson.416@osu.edu
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VISION The William G. Lowrie Department of Chemical and Biomolecular Engineering will provide an outstanding educational experience to our students and serve the profession and society by creating new knowledge through cuttingedge disciplinary and interdisciplinary research and disseminating this knowledge to industry, government, the scientific community and the general public. This new knowledge will consist of, but not be limited to, peer-reviewed publications, materials, processes, systems, software and other work products that will enhance societal quality of life. We will also create a learning environment that fosters diversity in teaching, scholarship and personnel practices.
MISSION
GOALS
• To create new knowledge in the field of Chemical and Biomolecular Engineering through cuttingedge research and pass this new knowledge on to our students, our profession, and society in general.
• To develop an educational program at both the undergraduate and graduate levels that is recognized as one of the top twenty programs in the nation.
• To educate undergraduate and graduate students in Chemical and Biomolecular Engineering and foster cross-fertilization of allied fields.
• To develop a research program that is recognized as one of the top twenty programs in the nation.
• To serve the public, academic, industrial and government communities through consultation, collaborative efforts, entrepreneurial activity, dissemination of research results and outreach activities. • To create a learning environment that fosters diversity in scholarship, teaching and in student, faculty and staff composition. • To instill in our students an appreciation of, and the necessity for, life-long learning, team work and to provide them the skills to prosper in a global economy.
• To serve as a recognized authority in chemical and biomolecular engineering for the public, industry and all levels of government. • To establish our innovations in education, discoveries/advances in research, and our successes in diversity as models for other departments, colleges and universities. • To leverage the new state-of-the-art Koffolt Laboratories, one that meets the requirements for modern education and research in Chemical and Biomolecular Engineering, to recruit the best students and faculty and foster exceptional teaching and research.
KEY FACTS
Faculty
22 tenure-track
3 National Academy of Engineering members 4 3 2 6
Endowed chairs College of Engineering distinguished professors Endowed professorships AIMBE Fellows
$7.8M in 2017 Research Expenditures 7 5 7 166
Keynotes/distinguished lectures
• Innovative membranes for gas separations and carbon dioxide capture
Publications (cumulative)
AIChE Awards (Institute Lecturer, Founders, Wilhelms, etc.)
• Tissue engineering and biomaterials for transfusion medicine
National Science Foundation CAREER Awards
• Cutting-edge research in catalysis
Fulbrights
• Polymer-based nanoengineering leading to new materials and devices benefitting manufacturing processes and medical diagnostics.
R&D 100 Awards
Graduate Program
#26 in 2019 U.S. News and World Report
18 9 2
Facilities
• 225,000-square-foot building, new in 2015
Ph.D. degrees awarded in 2017 National student awards NSF Graduate Research Fellowships
25 National Scholarships
22 5 2 1
• Immunomagnetic cell separation, cancer diagnostics and cell migration
American Chemical Society Awards
• Groundbreaking self-cleaving affinity tagging for protein purification • Leaders in nanobiotech and the development of magnetic quantum dots for diagnostics
Named invited lectures
40 16 10 2 2
• ‘One-touch healing’ tissue-regenerating nanochip
Patents issued
260 National / int’l Faculty Awards
• World leader in chemical looping processes that conserve resources and reduce emissions
• Development of world’s most cubic ice and other innovations in aerosol science and sustainable engineering
Top Research Achievements (cumulative)
Philanthropy •
138 scholarships ($344,550 awarded in 2017)
(cumulative)
NSF Graduate Research Fellowships in the last 12 years Barry Goldwater Scholarships Fulbrights Morris K. Udall
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FACULTY NEWS L.-S. FAN REACHES BREAKTHROUGH IN FOSSIL FUEL TECHNOLOGY THAT DOESN’T POLLUTE Process achieves negative CO2 impact and greater efficiency due to new, highly durable particle
Liang-Shih Fan
Engineers at The Ohio State University are developing technologies that have the potential to economically convert fossil fuels and biomass into useful products including electricity without emitting carbon dioxide to the atmosphere.
In the first of two papers published in the journal Energy & Environmental Science, the engineers report that they’ve devised a process that transforms shale gas into products such as methanol and gasoline—all while consuming carbon dioxide. This process can also be applied to coal and biomass to produce useful products. Under certain conditions, the technology consumes all the carbon dioxide it produces plus additional carbon dioxide from an outside source. In the second paper, they report that they’ve found a way to greatly extend the lifetime of the particles that enable the chemical reaction to transform coal or other fuels to electricity and useful products over a length of time that is useful for commercial operation. Finally, the same team has discovered and patented a way with the potential to lower the capital costs in producing a fuel gas called synthesis gas, or “syngas,” by about 50 percent over the traditional technology. -6-
The technology, known as chemical looping, uses metal oxide particles in high-pressure reactors to “burn” fossil fuels and biomass without the presence of oxygen in the air. The metal oxide provides the oxygen for the reaction.
continuous operation, the engineers have since developed a new formulation that lasts for more than 3,000 cycles, or more than eight months of continuous use in laboratory tests. A similar formulation has also been tested at sub-pilot and pilot plants.
Chemical looping is capable of acting as a stopgap technology that can provide clean electricity until renewable energies such as solar and wind become both widely available and affordable, the engineers said. “Renewables are the future,” said Liang-Shih Fan, Distinguished University Professor in Chemical and Biomolecular Engineering, who leads the effort. “We need a bridge that allows us to create clean energy until we get there—something affordable we can use for the next 30 years or more, while wind and solar power become the prevailing technologies.” Five years ago, Fan and his research team demonstrated a technology called coal-direct chemical looping (CDCL) combustion, in which they were able to release energy from coal while capturing more than 99 percent of the resulting carbon dioxide, preventing its emission to the environment. The key advance of CDCL came in the form of iron oxide particles which supply the oxygen for chemical combustion in a moving bed reactor. After combustion, the particles take back the oxygen from air, and the cycle begins again. The challenge then, as now, was how to keep the particles from wearing out, said Andrew Tong, research assistant professor of chemical and biomolecular engineering at Ohio State. While five years ago the particles for CDCL lasted through 100 cycles for more than eight days of
Andrew Tong. -Photo by Jo McCulty, 2017.
“The particle itself is a vessel, and it’s carrying the oxygen back and forth in this process, eventually falling apart. Like a truck transporting goods on a highway, eventually it’s going to undergo some wear and tear. We devised a particle that can make the trip 3,000 times in the lab and still maintain its integrity,” Tong said. This is the longest lifetime ever reported for the oxygen carrier, he added. The next step is to test the carrier in an integrated coal-fired chemical looping process. Another advancement involves the engineers’ development of chemical looping for production of syngas, which in turn provides the building blocks for a host of other useful products including ammonia, plastics or even carbon fibers.
This is where the technology really gets interesting: It provides a potential industrial use for carbon dioxide as a raw material for producing useful, everyday products. Today, when carbon dioxide is scrubbed from power plant exhaust, it is intended to be buried to keep it from entering the atmosphere as a greenhouse gas. In this new scenario, some of the scrubbed carbon dioxide wouldn’t need to be buried; it could be converted into useful products. Taken together, Fan said, these advancements bring Ohio State’s chemical looping technology many steps closer to commercialization. He calls the most recent advances “significant and exciting,” and they’ve been a long time coming. True innovations in science are uncommon, and when they do happen, they’re not sudden. They’re usually the result of decades of concerted effort—or, in Fan’s case, the result of 40 years of research at Ohio State. Throughout some of that time, his work has been supported by the U.S. Department of Energy and the Ohio Development Services Agency. “This is my life’s work,” Fan said. His co-authors on the first paper include postdoctoral researcher Mandar Kathe; undergraduate researchers Abbey Empfield, Peter Sandvik, Charles Fryer, and Elena Blair; and doctoral student Yitao Zhang. Co-authors on the second paper include doctoral student Cheng Chung, postdoctoral researcher Lang Qin, and master’s student Vedant Shah. Collaborators on the pressure adjustment assembly work include Tong, Kathe and senior research associate Dawei Wang.
The university would like to partner with industry to further develop the technology. The Linde Group, a provider of hydrogen and synthesis gas supply and plants, has already begun collaborating with the team. Andreas Rupieper, the head of Linde Group R&D at Technology & Innovation said that the ability to capture carbon dioxide in hydrogen production plants and use it downstream to make products at a competitive cost “could bridge the transition towards a decarbonized hydrogen production future.” He added that “Linde considers Ohio State’s chemical looping platform technology for hydrogen production to be a potential alternative technology for its new-built plants.” The Babcock & Wilcox Company (B&W), which produces clean energy technologies for power markets, has been collaborating with Ohio State for the past 10 years on the development of the CDCL technology – an advanced oxy-combustion technology for electricity production from coal with nearly zero carbon emissions. David Kraft, Technical Fellow at B&W, stated “The CDCL process is the most advanced and cost-effective approach to carbon capture we have reviewed to date and are committed to supporting its commercial viability through largescale pilot plant design and feasibility studies. With the continued success of collaborative development program with Ohio State, B&W believes CDCL has potential to transform the power and petrochemical industries.”
New materials under development at The Ohio State University, including a patented iron oxide particle (left), are enabling cleaner fossil fuel technologies.
-Photo by Jo McCulty, 2017.
To view animations of Chemical Looping Gasification for Producing Syngas from Coal, Natural Gas, Biomass and CO2 and other animations, visit http://go.osu.edu/ ChemLoopAnim
___ “Utilization of C02 as a partial substitute for methane feedstock in chemical looping methane-steam redox processes for syngas production,” Energy & Environmental Science, Issue 6, 2017. -7-
L. JAMES LEE DEVELOPS BREAKTHROUGH ‘ONE TOUCH HEALING’ NANOCHIP The future has arrived! Researchers at Ohio State’s College of Engineering and The Ohio State University Wexner Medical Center have developed a new technology, Tissue Nanotransfection (TNT), that may be used to repair or restore injured or aging tissue, including blood vessels, nerve cells, and possibly entire organs. The device converts skin or tissue into elements of any organ with just one touch. It takes just a fraction of a second. The chip is touched to the wounded area, injects genetic code into the skin, and is then removed. At that point, cell reprogramming begins, and the patient’s own body generates whatever cell type is needed to treat the disease or wound. The device could save the lives of car crash victims or injured soliders, and restore brain function after strokes.
Active blood vessels soon appeared in the animals treated with the device, and by the third week, the legs were saved. In lab tests, this technology was also shown to reprogram skin cells in the live body into nerve cells that were injected into braininjured mice to help them recover from stroke.
Results of the regenerative medicine study were published in Nature Nanotechnology and appeared in numerous news outlets worldwide. “TNT technology has two major components: A nanotechnology-based chip designed to deliver “It extends the concept known as gene therapy,” cargo to adult cells in the live body, and the design said CBE Professor L. James Lee. “The difference of the specific biological cargo for cell conversion. is how we deliver the DNA into the cells.” This cargo, when delivered via the chip, converts an adult cell from one type to another,” said The project began as a simple idea, but Lee and Gallego-Perez, who is now an assistant professor Daniel Gallego-Perez (‘11), who worked on the of biomedical engineering and general surgery in project as a post-doc in Dr. Lee’s lab, were soon Sen’s laboratory. surprised by how well it worked -- up to 98 percent efficiently. After initial results proved promising, Researchers plan to start clinical trials next year they partnered with the Wexner Medical Center to to test this technology in humans, and Lee is initiate animal studies. implementing further studies to understand the mechanism for further improvements. There, Drs. Gallego-Perez and Chandan Sen, director of Ohio State’s Center for Regenerative Funding for this research was provided by Ohio Medicine & Cell Based Therapies, worked with State’s Center for Regenerative Medicine and other researchers to reprogram skin cells to Cell-Based Therapies, Ohio State’s Nanoscale become vascular cells in the badly injured legs of Science and Engineering Center and Leslie and mice and pigs that lacked blood flow. Abigail Wexner. -8-
James Lee (left) and Junfeng Shi examine a silicon chip used to transform skin cells into other types of cells needed to heal injuries or damaged tissue. Lee led a team of engineers who designed the Tissue Nanotransfection (TNT) chip and collaborated with The Ohio State University Wexner Medical Center to implement further testing.
Daniel Gallego-Perez (center, CBE ‘11 Ph.D.), who played a key role in developing the technology, demonstrates the tissue nanotransfection process. TNT does not require any laboratory-based procedures and can be implemented at the point of care, delivering its cargo in a tiny electrical zap that is barely felt by the patient.
For more information, watch a video: http://go.osu.edu/OneTouch
WORLD’S ‘SQUAREST’ ICE CREATED BY BARBARA WYSLOUZIL WILL ASSIST CLIMATE STUDIES An international team of scientists has set a new record for creating ice crystals that have a nearperfect cubic arrangement of water molecules—a form of ice that may exist in the coldest high-altitude clouds but is extremely hard to make on Earth.
she said. “So the question is, how cubic can we make it with current technology? Previous experiments and computer simulations observed ice that is about 75 percent cubic, which we have exceeded,” Dr. Wyslouzil said.
The ability to make and study cubic ice in the laboratory could improve computer models of how clouds interact with sunlight and the atmosphere— two keys to understanding climate change, said Barbara Wyslouzil, project leader and professor of chemical and biomolecular engineering at The Ohio State University. It could also enhance our understanding of water – one of the most important molecules for life on our planet.
To make the highly cubic ice, researchers drew nitrogen and water vapor through nozzles at supersonic speeds. When the gas expanded, it cooled and formed droplets a hundred thousand times smaller than the average raindrop. These droplets were highly supercooled, meaning that they were liquid well below the usual freezing temperature of 32 degrees Fahrenheit. In fact, the droplets remained liquid until about -55 degrees Fahrenheit (around -48 degrees Celsius) and then froze in about a millionth of a second.
Seen under a microscope, normal water ice— everything from frozen ponds, to snow, to the ice we make at home—is made of crystals with hexagonal symmetry, Wyslouzil explained. But with only a slight change in how the water molecules are arranged in ice, the crystals can take on a cubic form. So far, researchers have used the presence of cold cubic ice clouds high above the earth’s surface to explain interesting halos observed around the sun, as well as the presence of triangular ice crystals in the atmosphere. Scientists have struggled for decades to make cubic ice in the laboratory, but because the cubic form is unstable, the closest anyone has come is to make hybrid crystals that are around 70 percent cubic, 30 percent hexagonal. In a paper published in the Journal of Physical Chemistry Letters, Wyslouzil, graduate research associate Andrew Amaya and their collaborators describe how they were able to create frozen water droplets that were nearly 80 percent cubic. “While 80 percent might not sound ‘near perfect,’ most researchers no longer believe that 100 percent pure cubic ice is attainable in the lab or in nature,”
Left: ice clouds scatter light, sometimes creating haloes around the sun. To better understand how clouds interact with sunlight and the atmosphere, researchers have created a special form of ice in the laboratory. Right: The newly-created ice crystals scatter X-rays into a pattern of concentric circles with a particular frequency and intensity, indicating that water molecules in the crystals have a nearperfect cubic arrangement. -Photo via Pixabay, X-ray diffraction image courtesy of The Ohio State University.
To measure the cubicity of the ice formed in the nozzle, researchers performed X-ray diffraction experiments at the Linac Coherent Light Source (LCLS) at the SLAC National Accelerator Laboratory in Menlo Park, CA. There, they hit the droplets with the high-intensity X-ray laser from LCLS and recorded the diffraction pattern on an X-ray camera. They saw concentric rings at wavelengths and intensities that indicated the crystals were around 80 percent cubic. Extremely low temperatures and rapid freezing were crucial to forming cubic ice, Wyslouzil said: “Since liquid water drops in high-altitude clouds are typically supercooled, there is a good chance for cubic ice to form there.” Exactly why it was possible to make crystals with around 80 percent cubicity is currently unknown. But, then again, exactly how water freezes on the molecular level is also unknown. The research was funded by the National Science Foundation, the U.S. Department of Energy and SLAC. -Story by Pam Frost Gorder.
Barbara Wyslouzil in the studio awaiting her interview on PBS’s “Science Fridays” series. Listen to the July 14, 2017 broadcast at go.osu.edu/icecube
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FACULTY AWARDS AND HONORS STUART COOPER ARAVIND ASTHAGIRI • Published in Science magazine (2017)
• President, Sigma Xi (2017-18) • 2018 Faculty Mentoring Award, College of Engineering
BHAVIK BAKSHI ILHAM EL-MONIER • Research featured in Nature Energy (April 11, 2017) • Named to the Richard M. Morrow Endowed Chair • 2017 Outstanding Paper Award, Clean Technologies and Environmental Policy (with Varsha Gopalakrishnan)
• 2017 Subsurface Energy Resource Center (SERC) Faculty Fellowship
NICHOLAS BRUNELLI
L.-S. FAN
• 2017 NSF CAREER Award • 2017 Innovation Award - Most Invention Disclosures Filed, OSU Institute of Materials Research
• 2017 AIChE Ansys Particle Technology Forum Service Award • 2017 Innovation Award - Most Patents Filed, OSU Institute of Materials Research
LISA HALL JOHN CLAY • 2017 Alumni Award for Distinguished Teaching, The Ohio State University’s highest teaching honor
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• Article featured on cover of Journal of Chemical Physics (2017; with Janani Sampath) • 2017 Summer Research Fellowship, Air Force Research Laboratory • 2018 Lumley Research Award, College of Engineering
W.S. WINSTON HO EDUARDO REÁTEGUI • Honorary International Chair Professor, Tianjin Polytechnic University, Tianjin, China, 2017-present • 2017 Accelerator Award, OSU Office of Technology Commercialization • 2017 Innovation Award - Most Patents Filed, OSU Institute of Materials Research
• Published in Nature Biomedical Engineering (2017), Nature Materials (2017), and Nature Communications (2018)
L. JAMES LEE • Published in Nature Communications, Nature Nanotechnology • Foreign Master Professorship, Dalian University of Technology, China • 2017 Innovation Award - Most Invention Disclosures Filed, OSU Institute of Materials Research
LI-CHIANG LIN • ACS Editor’s Choice, Journal of Physical Chemistry C spotlight for April 11, 2017 • Articles featured on the covers of Journal of Physical Chemistry C (2017, 2018), ChemPhysChem (2017) and Molecular Systems Design and Engineering (2016)
UMIT OZKAN • 2017 American Chemical Society Energy and Fuels Division Henry H. Storch Award • 2017 University Laboratory Safety Committee Excellence in Safety Award-Group (inaugural award) • 2018 Lumley Interdisciplinary Research Award, College of Engineering
KATELYN SWINDLE-REILLY • 2017 Lois Hagelberger-Huebner Young Investigator Award, Ohio Lions Eye Research Foundation (inaugural recipient)
JESSICA WINTER • Congressional presenter, House and Senate briefings on value of federally-funded research (invited by NSF Coalition for National Science Funding), October 2017 • Congressional presenter (invited by NSF Office of Legislative and Public Affairs), February 2017 • 2017 Dean’s Award for Distinguished Outreach Achievements, College of Engineering • 2018 Innovators Award, College of Engineering
BARBARA WYSLOUZIL • Interviewed on Science Friday upon setting a world record for creating the most cubic ice.
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THREE NEW FACULTY MEMBERS JOIN DEPARTMENT OF CHEMICAL ENGINEERING EDUARDO REÁTEGUI is never satisfied with achieving his initial goal. As a result, he is able to surpass his own initial vision. “I am passionate about improving outcomes, and an never satisfied with achieving the goal I set out to achieve. Rather, I am passtionate about understanding what else could be added to improve a certain outcome,” Professor Reátegui said.
Dr. Reátegui obtained his Ph.D. in mechanical engineering from the University of Minnesota in 2011, where his doctoral research won the Best Dissertation Award in Physical Sciences and Engineering. Dr. Reátegui has three patents and five more patents pending. His 19 peer-reviewed articles to date appear in different leading journals such as Nature Communications, Nature Biomedical Engineering, Nature Materials, Journal of the American Chemical Society and Advanced Materials.
Professor Reátegui’s new appointment as an assistant professor in the William G. Lowrie Department of Chemical and Biomolecular Engineering at The Ohio State University is in conjunction with the Comprehensive Cancer Center at Ohio State’s Wexner Medical Center. His research focuses on the development of translational microtechnologies combining microfluidics, biomaterials, and molecular imaging techniques to help better diagnose, study, and treat cancer and infectious diseases. He seeks to bridge engineering disciplines with biology to exploit complex cellular interactions and mechanisms towards the goal of solving unmet needs in life sciences and medicine.
ANDREW TONG, previously named a research assistant professor in 2015, has now assumed additional teaching responsibilities as a clinical assistant professor. Dr. Tong has had remarkable success in grant writing, securing over $10M in funding from the DOE (National Energy Technology Laboratory), State of Ohio agencies, and others for research projects in chemical looping for CO2 capture from coal and the conversion of biomass to high-value chemicals. Future work includes completing the design and development of a large-scale coal-direct chemical looping 10 MWe test unit. Dr. Tong’s teaching goal is to use his research experience in the process development, safety and economic assessment of chemical looping technologies to connect these course concepts with students.
Currently, Dr. Reátegui is working on expanding the applications of circulating biomarkers not only as a diagnostic tool but also exploring their role in cancer metastasis and cell-to-cell communication with the immune system. As a post-doc at Harvard Medical School under the mentorship of Dr. Mehmet Toner and Dr. Shannon Stott, he developed a non-invasive “liquid biopsy” microfluidic device that sorts out circulating tumor cells (CTCs) and extracellular tumor vesicles (EVs) present in the blood of cancer patients. - 12 -
Dr. Tong obtained his Ph.D. in 2014 from The Ohio State University, where he won three awards for research and outstanding academic achievement and mentored 11 students in Dr. L.-S. Fan’s lab. He has published two book chapters and 13 articles in the journals Applied Energy, Energy and Environmental Science, Energy & Fuels, and Fuel, and has one patent.
ANDREW MAXSON was named clinical assistant professor in the Unit Operations Laboratory. As a Buckeye who completed his Ph.D. here, he is thrilled to join the faculty and loves his new role as a professor. “A major motivation for me in teaching is to share the lessons learned from my nearly ten years of industry experience,” said Maxson, who worked in process engineering at General Motors and Whirlpool. “With that goal in mind, I have created case studies based on my experiences and incorporated them into the lecture material in Unit Ops.” Already having made major improvements to the laboratory, enhancing safety, updating and adding experiments, and allowing students to design their own experiments, he went on to enable TAs to use their time more efficiently by reprogramming the PID control software on the distliiation experiment to allow the valves on the colums to be controlled automatically. A graduate of the Rose-Hulman Institute of Technology, he won three awards for outstanding academic achievement as an Ohio State graduate student and mentored 14 undergrads in Dr. Jack Zakin’s laboratory. He plans to continue the research that he and Professor Zakin undertook. Published works include articles in Rheologica Acta, International Journal of Heat and Mass Transfer, and a chapter in “Wormlike Micelles: Advances in Systems, Characterisation and Applications,” published by the Royal Society of Chemistry.
FACULTY RESEARCH 2016-17 FY RESEARCH FUNDING
RESEARCH FUNDING 2017 Total / Indirect Research Expenditures 18
Total Awards:
2016
2017
51
38
16 14 12 10 8
Total Expenditures:
$7,127,633
$7,884,846
Indirect Costs:
$1,990,418
$1,861,884
Avg. Exp. / Faculty:
$339,411 $358,402
Industry Funding:
$782,490 $482,835
6 4 2 0 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 Total
Indirect Costs
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2017 RESEARCH HIGHLIGHTS ARAVIND ASTHAGIRI: Our publication in Science and JACS on alkane activation and selective conversion on IrO2(110) surface demonstrates that the IrO2(110) surface can activate methane and ethane at extremely low temperatures (below room temperature) and shows that modifications of the surface can promote ethane conversion to ethylene versus full combustion. Benefit: Selective conversion of alkanes at lower temperatures would be transformative. Such technology would allow us to convert our large natural gas resources to more high value chemicals and liquid fuels. Key Publications: Science; selected for Journal of American Society (JACS) Spotlights. BHAVIK BAKSHI: Developed an approach for including ecosystem services in life cycle assessment and demonstrated its benefits by application to the assessment of corn ethanol. Benefit: This achievement is an important step toward accounting for the role played by nature for supporting human activities and for assessing their sustainability. The impact of this development is that with this approach, efforts toward sustainable engineering can not only improve technological systems but also protect and restore ecological systems. Key Publications: Applied Energy. NICHOLAS BRUNELLI: Selective catalyst for isomerization of glucose to fructose. Benefit: Identifying selective catalyst for converting biomass will help transform our ability to produce chemicals in a sustainable manner. Key Publications: Journal of Catalysis. Awards/Honors: 2017 NSF CAREER Award. Student Lagnajit Pattanaik received a Goldwater Scholarship. L.-S. FAN: Developed highly durable particle that brings even greater cost-effectiveness to chemical looping technologies that convert fossil fuels and biomass into useful products (including electricity) without emitting CO2. Patented a way to potentially lower capital costs in producing a fuel gas called synthesis gas (“syngas”) by about 50 percent over - 14 -
traditional technology. Benefits: These economical processes consume their own carbon dioxide emissions and draw CO2 from the atmosphere while transforming shale gas into products such as methanol and gasoline, providing major potential commercial applications for clean energy. Key Publications: Energy & Environmental Science, Journal of Materials Chemistry A, Applied Energy, ACS Energy Letters, Physical Chemistry Chemical Physics, Acta Materialia, Internal Journal of H2 Energy. Awards/Honors: 2017 Ansys Particle Technology Forum Award for Service, AIChE Particle Technology Forum.
(a mesoscopic simulation method) and in reverse nonequilibrium molecular dynamics (a method often used for computing transport coefficients in molecular simulation). We developed a method to eliminate this energy drift. Benefit: This is a step toward efficient computational tools for studying transport phenomena in nanoscale systems.
L. JAMES LEE: In collaboration with medical researchers at Ohio State, we published a novel biomedical technology, called Tissue Nanoelectroportation Transfection (TNT) which is able to conduct in vivo cell reprogramming LISA HALL: Showed excellent agreement between for regenerative medicine. We successfully experimental results and theoretical calculations of demonstrated induced neuro cells for stoke recovery the density profile of microphase separated polymers and induced endothelial cells for blood vessel with different sequences. See Luo M; Brown JR; Remy generation and wound healing in mouse models. RA; Scott DM; Mackay ME; Hall LM; Epps TH. (2016). This work was published in Nature Nanotechnology Determination of Interfacial Mixing in Tapered Block in October 2017. We also developed a new tethered Polymer Thin Films: Experimental and Theoretical lipoplex nanoparticle (TLN) biochip technology which Investigations. Macromolecules, 49(14). Benefit: This can detect pancreatic cancer in early stage by testing work improves our ability to design nanostructured a specific mRNA target, Glypican 1, in extracellular polymers with a particular length scale of ordering. vesicles existed in human blood. This ‘liquid biopsy’ Key Publications: Physical Review Letters. technique was published in Nature Communication in November 2017. Benefit: The TNT technology has W.S. WINSTON HO: Developed and scaled up CO2- a great potential for regenerative medicine and it has selective membranes. The scale-up membranes gained a great deal of publicity worldwide. But more have moved from our lab to the commercialization animal studies are needed to reach clinical trials in the for hydrogen purification for fuel cells and to the future. The TLN biochip technology has also gained a field testing for carbon capture from flue gas in the lot of attention in the medical field because there is no National Carbon Capture Center in the coal- and viable pancreatic cancer diagnosis method today and natural gas-fired power plant in Wilsonville, Alabama. mortality is very high due to late finding of this deadly Benefit: The membrane for fuel cells can increase disease. Key Publications: Nature Nanotechnology, energy efficiency and provide zero-carbon electricity Nature Communications. generation. The membrane for carbon capture is promising for cost-effective CO2 capture from flue LI-CHIANG LIN: a) Computationally identified the gas. Key Publications: Journal of Membrane Science. potential and design principles of zeolite nanosheets and single-walled aluminosilicate nanotubes for water ISAMU KUSAKA: Common algorithms of molecular desalination. b) Developed molecular simulation dynamics simulation can exhibit a fictitious secular approaches to understand the effects of zeolite energy drift, i.e., the energy of the system changes topology and Al distributions on thermodynamics linearly with time, even though the underlying of n-alkane adsorption toward the design of zeolite dynamics conserves energy. This is the case in catalysts for alkane cracking. c) Understand the role dissipative particle dynamics with energy conservation of defects in metal-organic frameworks (MOFs) for
- FACULTY RESEARCH developing better water adsorbents. Benefit: ANDRE PALMER: Demonstrated that we can target Outcomes could facilitate the development of new oxygen delivery to cells and tissues using oxygen materials toward more energy-efficient & cost- carriers with tunable oxygen affinity. Benefit: These effective processes. Key Publications: ACS Catalysis, materials can be used to potentially treat patients Journal of Physical Chemistry C (cover feature; ACS suffering from blood loss or anemia, and can be used Editors’ choice), ChemPhysChem (front and back to oxygenate tissue engineered constructs. Awards/ cover features). Honors: Member, Bioengineering, Technology, and Surgical Sciences (BTSS) study section, National ANDY MAXSON: Developed a “smart, switchable” Institutes of Health. 2017 NSF Graduate Research wormlike micelle solution with extreme sensitivity Award for student Richard Hickey. to temperature, shear and composition for real-time control of drag reduction and heat transfer reduction. EDUARDO REÁTEGUI: A study on the tumor-specific This was the “holy grail” sought by Jack Zakin in the isolation of extracellular vesicles from brain cancer latter part of his research career. Benefit: Turbulent patients that uses microfluidic technologies and RNA drag reducing additives can reduce pumping energy sequencing demonstrates the potential of liquid-tumor requirements in large recirculating systems by more biopsies to provide accurate and equivalent results than 50%, but there is a negative impact on heat to traditional tissue biopsies. Benefit: Liquid-tumor transfer equipment like heat exchangers, boilers, and biopsies will enable the development of personalized chillers. This new technology allows drag reduction cancer treatments, and could help detect cancer at an to be switched on and off in real time, allowing the earlier, more curable, stage. Key Publications: Nature use of drag reducing additives in large district heating Communications, Nature Biomedical Engineering, systems, where their poor heat transfer properties and Nature Materials, EJACS. have previously prevented their use. JAMES RATHMAN: Invited lead author, “Role of UMIT S. OZKAN: Demonstrated the viability of chemoinformatics in regulatory science,” chapter to be electrocatalysts that we developed (heteroatom- published in the new edition of the Chemoinformatics Gasteiger and Engel. Benefit: doped carbon nano-structures) for electrochemical textbook by Computational models for evaluating the potential for chlorine production as both anode and cathode various types toxicity for a compound of interest. catalysts. Benefit: Chlorine is an essential chemical in a vast majority of processes that produce many indispensable products, especially polymers KATELYN SWINDLE-REILLY: Funded research project, such as polyvinyl chloride, polyurethanes and “Sustained Release Bevacizumab Injectable for the chloroaromatics. It is a component in about 93% Treatment of Wet Age-Related Macular Degeneration,” of life saving pharmaceuticals, 86% of pesticides, to create a new intraocular delivery system for AMD. fiber optics, hypochlorite bleaches and many more Benefit: The current standard of care is monthly commodities. This research accomplishment has intraocular injections – sustained release technology the potential to replace a very energy-intensive and would reduce frequency of injection. Awards/ expensive process with a less expensive alternative. Honors: Ohio Lions Eye Research Foundation Lois Key Publications: Applied Catalysis B: Environmental, Hagelberger Huebner Young Investigator Award. Catalysis Letters. Awards/Honors: First woman to receive the American Chemical Society Energy and JESSICA WINTER: Winter (in collaboration with Wyslouzil) developed a new nanomanufacturing Fuels Division Henry H. Storch Award. method for generating nanoparticles for medical
applications. Particles can be produced in large quantity with high encapsulation efficiency of drugs and imaging agents with very narrow size distribution. Benefit: Could lead to new nutraceuticals, cancer therapies and disease imaging agents. Awards/ Honors: Congressional committee presentations: “Sparking Economic Growth,” House R&D Caucus and Senate Competitiveness Caucus, Washington, D.C., October 25, 2017. DAVID WOOD: Patent approved and promising USPTO office action on a second patent application. Benefit: This patent is on a new platform technology for purifying recombinant proteins, which has the potential to accelerate research and simplify the manufacture of therapeutic proteins. The result would be new and cheaper biopharmaceuticals entering the market. Key Publications: ACS Analytical Chemistry. BARBARA WYSLOUZIL: Analysis of our experiments that used an X-ray Free Electron laser to investigate the structure of ice nanoparticles, confirmed simulation results that ice formed from highly supercooled liquid water is not pure cubic ice. Fitting the X-ray scattering spectra, however, suggests that this “stacking disordered” ice is ~ 80% cubic making it the “most cubic” ice observed to date. Benefit: The structure ice I adopts in cold cirrus clouds has important atmospheric implications with respect to how sunlight interacts the clouds and, thus, affects models of climate change. Key Publications: Journal of Physical Chemistry Letters. Awards/Honors: Interviewed on Science Friday. S.T. YANG: Several metabolically engineered strains of clostridia were developed for n-butanol production from lignocellulosic biomass and CO2, which can lower biobutanol production cost and reduce green house gas emissions by more than 50% compared to existing technologies. Benefit: An economical production process for green biofuels from renewable biomass and industrial waste gas (CO2) is sustainable and will benefit the biorefinery industry and society. - 15 -
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$110,000 (2016-2018) Aravind Asthagiri, co-PI, Jay Gupta PI (OSU); ACS Petroleum Research Fund: Studies of CO2 photoreduction on Cu2O at the single molecule level. $625,000 (2017-2020) Aravind Asthagiri, Anne Co, co-PIs, Umit Ozkan, PI (OSU); DOE-BES: Tailoring the active sites in heteroatom-doped carbon catalysts for oxygen reduction and oxygen evolution reactions.
ARAVIND ASTHAGIRI Associate Professor, Ph.D. Carnegie Mellon. Computational catalysis, energy and sustainability. Refereed Papers Y. Bian, M. Kim, T. Li, A. Asthagiri, and J.F. Weaver, “Facile Dehydrogenation of Ethane on the IrO2(110) Surface,” J. Amer. Chem. Soc., 140, 2665 (2018). To be featured in JACS Spotlights. Z. Liang, M. Kim, T. Li, R. Rai, A. Asthagiri, and J.F. Weaver, “Adsorption and Oxidation of Ethylene on the Stoichiometric and O-Rich RuO2(110) Surfaces,” J. Phys. Chem. C, 37 20375-20386 (2017). Z. Liang, M. Kim, A. Asthagiri, and J.F. Weaver, “Dissociative chemisorption and oxidation of H2 on the stoichiometric IrO2(110) surface,” Topics in Catalysis, DOI:10.1007/s11244017-0877-y (2017). Z. Liang, T. Li, M. Kim, A. Asthagiri, and J.F. Weaver, “Lowtemperature activation of methane on the IrO2(110) surface,” Science, 356 299 (2017). Grant Support $600,000 (2015-2018) Aravind Asthagiri, co-PI; Jason Weaver PI (Univ of Florida); DOE-BES: Oxidation Chemistry on Pd and Pd-Pt Oxide Surfaces.
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$450,000 (2017-2020) Aravind Asthagiri, co-PI; Robert Baker, PI (OSU); National Science Foundation, SUSChem: CO2 Photo-Electrochemistry on Metal Oxide Surfaces Studied by Vibrational Sum Frequency Generation Spectroscopy and DFT.
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S. B. Jadhao, A. B. Pandit, and B. R. Bakshi. “The Evolving Metabolism of a Developing Economy: India’s Exergy Flows over Four Decades,” Applied Energy, 206, 851-857 (2017). R. J. Hanes, V. Gopalakrishnan, and B. R. Bakshi. “Synergies and trade-offs in renewable energy landscapes: Balancing energy production with economics and ecosystem services,” Applied Energy, 199, 25–44 (2017). X. Liu, S. Singh, E. L. Gibbemeyer, B. Tam, R. A. Urban, and B. R. Bakshi. “The Carbon-Nitrogen Nexus of Transportation Fuels,” Journal of Cleaner Production, 180, 790-803 (2018).
BHAVIK R. BAKSHI Professor, Ph.D. MIT. Sustainability science and engineering, process systems engineering. Awards and Honors CBE Distinguished Lecture, Western University, London, Ontario, Canada, Bakshi, B. R., “Innovation and Sustainability by Seeking Synergies with Nature,” March 30, 2017. Books and Book Chapters V. Gopalakrishnan and B. R. Bakshi. “Including Nature in Engineering Decisions for Sustainability,” Encyclopedia of Sustainable Technologies. Ed. by Martin Abraham. Elsevier, (2017). Refereed Papers S. B. Jadhao, S. G. Shingade, A. B. Pandit, and B. R. Bakshi, “Bury, Burn, or Gasify: Assessing Municipal Solid Waste Management Options in Indian Megacities by Exergy Analysis,” Clean Technologies and Environmental Policy, 206, 851-857 (2017). A. Ramaswami, D. Boyer, A. Nagpure, A. Fang, S. Bogra, B. Bakshi, E. Cohen, and A. Rao-Ghorpade, “An urban systems framework to assess the trans-boundary food-energywater nexus: implementation in Delhi, India,” Environmental Research Letters, 12, 2, 025008, (2017).
T. Ghosh and B. R. Bakshi. “Process to Planet approach to Sustainable Process Design: Multiple Objectives and Byproducts,” Theoretical Foundations of Chemical Engineering, 51, 6, 936–948 (2017). V. Gopalakrishnan, G. F. Grubb, and B. R. Bakshi. “Biosolids Management with Net-Zero CO2 Emissions: A TechnoEcological Synergy Design,” Clean Technologies and Environmental Policy, 19, 8, 2099–2111 (2017). X. Liu, B. R. Bakshi, “Ecosystem Services in Life Cycle Assessment while Encouraging Techno-Ecological Synergies,” Journal of Industrial Ecology, accepted (2017). F. Saladini, V. Gopalakrishnan, S. Bastianoni, and B. R. Bakshi. “Synergies Between Industry and Nature - An Energy Evaluation of a Biodiesel Production System Integrated with Ecological Systems.” Ecosystem Services, accepted (2018). B. R. Bakshi, T. G. Gutowski, and D. P. Sekulic. “Claiming Sustainability: Requirements and Challenges,” ACS Sustainable Chemistry and Engineering, accepted (2018). V. Gopalakrishnan and B. R. Bakshi. “Ecosystems as Unit Operations for Local Techno-Ecological Synergy: Integrated Process Design with Treatment Wetlands,” AIChE Journal, accepted (2018).
Grant Support $6,000,000 (2013-2017). Co-PIs Yebo Li, Bhavik R. Bakshi, and several others; U.S. Department of Agriculture, BRDI program: Bioenergy and Biofuels Production from Lignocellulosic Biomass via Anaerobic Digestion and Fisher-Tropsch Reaction. $300,000 (2013-2017). Co-PIs Bhavik R. Bakshi, OSU; Michael Lepech, Stanford University; National Science Foundation: Seeking Synergy Between Technological and Ecological Systems for Sustainable Engineering. $46,645 (2014-2017). Bhavik R. Bakshi; National Science Foundation: US-UK Planning Visit: Techno-Ecological Synergy for Sustainable Engineering. $410,000 out of $12 million (2015-2019). PI Anu Ramaswami, University of Minnesota; Bhavik R. Bakshi, OSU; National Science Foundation: SRN: Integrated Urban Infrastructure Solutions for Environmentally Sustainable, Healthy and Livable Cities. $99,994 out of $12 million (2015-2020). PI Charles Redman, Arizona State University; Bhavik R. Bakshi, OSU; National Science Foundation: SRN: Urban Resilience to Extremes. $179,085 (2016-2018). PI Bhavik R. Bakshi. Ford Motor Company: Life Cycle Assessmeent of Carbon Fiber Composites for Auto Applications. $35,000 (2017-2018). Co-PIs Bhavik R. Bakshi, Brent Sohngen and Sami Khanal, OSU. Addressing the WaterEnergy Nexus of Fossil Power Generation by Considering Technological, Agro-Ecological, and Economic Options in the Muskingum Watershed. $2,400,000 (2018-2021). Co-PIs Bhavik R. Bakshi, Elena Irwin and several others. National Science Foundation: Innovation at the Nexus of Food Energy and Water Systems: Impacts of Deglobalization on the Sustainability of Regional Food, Energy, Water Systems.
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$528,000 (2017-2022) PI Nicholas Brunelli; National Science Foundation CAREER – CBET: Increasing Catalytic Selectivity for Isomerization of Glucose to Fructose Using Paired Lewis Acid Sites (1653587).
Mahajan, K.D., Dorcéna, J., Bouxien, N.F., Bachand, G.D., Chalmers, J.J., Winter, J.O., “Controlled Propulsion and Orientation of Microtubule Molecular Shuttles Using a Magnetic Needle,” in Press in Biotechnology Journal. Sun, J., Moore, L., Xue, W., Kim, J., Zborowski, M., Chalmers, J.J. “The potential to separate intrinsically magnetic biological entities in a very high, well defined, microfluidic magnetic deposition system,” In Press in Biotechnology and Bioengineering. Mahajan, K.D., Cui, Y., Dorcéna, J., Bouxien, N.F., Bachand, G.D., Chalmers, J.J., Winter, J.O, “Magnetic Quantum Dots Steer and Detach Microtubules from Kinesin-Coated Surfaces.” Biotechnology Journal. 13:1700402 (2018).
NICHOLAS BRUNELLI Assistant Professor, Ph.D. California Institute of Technology. Heterogeneous and immobilized catalysis and catalytic materials; sustainability, energy, environment. Refereed Papers N. Deshpande, L. Pattanaik, M.R. Whitaker, C.-T. Yang, L.C. Lin, N.A. Brunelli, “Selectively Converting Glucose to Fructose Using Immobilized Tertiary Amines.” Journal of Catalysis, 353, doi: 10.1016/j.jcat.2017.07.021 (2017). Parulkar, A., Brunelli, N.A. “High Yield Synthesis of ZIF-8 Nnaoparticles using Stoichiometric Reactants in a JetMixing Reactor.” Industrial and Engineering Chemistry Research, 56 (37), 10384-10392 (2017). Grant Support $330,000 (2016-2019). PI Nicholas Brunelli; National Science Foundation CBET - Catalysis and Biocatalysis: Designing Cooperative Interactions to Increase Catalytic Performance for Biomass Conversion. $1,000,000 (2016-2019). PI Robert Baker; Co-PI Nicholas Brunelli; National Science Foundation MRI: Ambient Condition XP.
JEFFREY CHALMERS Professor, Ph.D. Cornell. Biochemical bioengineering, biomedical engineering.
engineering,
Books and Book Chapters Sutaria,D., Jiang,J., Phelps, M. , Elgamal, O., Pomeroy, S. M., Miller, B.L., Lustberg, M.B., Summers, T.A. Chalmers, Badawi, M. A., Chalmers, J. J. , Clara, A., Zhu, X., Li, C., J.J.,“Multispectral Imaging Analysis of Circulating Tumor “Low Active Loading of Cargo into Engineered Extracellular Cells in Negatively Enriched Peripheral Blood Samples,” Vesicles Results in Inefficient miRNA mimic delivery,” Methods Mol. Biol. 1634:219-234 (2017). Journal of Extracellular Vesicles 6 (1), 1333882 (2017). Zborowski, M., Chalmers, J.J., W.Lee, P. Tseng, “Magnetic Cell Manipulation and Sorting,” Microtechnology for Cell Manipulation and Sorting, D. DiCarlo, eds. Springer (2017). Refereed Papers Aljohani, HA, Furgason, J.M., Amaya, P. Deeb, A., Chalmers, J.J., Bahassi, E., “Genetic Mutations Associated with Lung Cancer Metastasis to the Brain,” in Press in Mutagenesis.
Moore, L.R., Yazer, M., Zborowski, M., Chalmers, J.J. “Continuous, intrinsic magnetic depletion of erythrocytes $110,000 (2016-2018) PI Nicholas Brunelli; ACS-PRF-DNI: from whole blood with a quadrupole magnet and annular Designing Uniform Paired Copper Catalytic Sites for flow channel; pilot scale study,” in Press in Biotechnology Conversion of Methane to Methanol. (PRF# 55946-DNI5). and Bioengineering.
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Mahajan, K.D., Nabar, G.M., Xue, W., Anghelina, M., Moldovan, N, Chalmers, J., Winter, J. “Mechanotransduction effects on endothelial cell proliferation via CD31 and VEGFR2: Implications for Immumomagnetic Separation.” Biotechnology Journal. 12(9), (2017).
Zhu, X., Badawi, M., Pomeroy, S. M.,Sutaria, D.S., Xie,, Z., Baek, A., Jiang, J., Elgamal, O J, Mo, X., Perle, K.L., Chalmers, J.J, Schmittgen, T.D., Phelps, M. “Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells,” Journal of Extracellular Vesicles 6(1), 1324730 (2017). Chalmers, J.J., Jin, X., Palmer, A., Yazer, M., Moore, L., Pan, J., Park, J. Zborowski, M.,” Femtogram resolution of iron content per cell: storage of red blood cells leads to loss of hemoglobin.” Analytical Chemistry 89(6):3702-3709 (2017).
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Moore, Lee. R., Williams, P.S., Chalmers, J.J., Zborowski, M., “Tessellated permanent magnetic circuits for flow-through, open gradient separations of weakly magnetic materials.“ J. of Magnetism and Magnetic Materials. Vol. 427:325-330 (2017). Grant Support $2.6M (2017-2020). Co-PIs Jeff Chalmers, Andre Palmer; NIH 1R01HL131720-01A1: Fractionation of Aged RBCs based on Hemoglobin Content. $64,000 out of $1,414,194 (2017-2018). Co-Investigator Jeff Chalmers; NIH UH2TR000914-02: Targeted delivery of microRNA-loaded microvesicles for cancer therapy. $20,000 out of $368,445 (2016-2017). Co-PI Jeff Chalmers; NCI (R21CA178649): Role of tumor-associated endothelial cells in chaperoning tumor cells.
STUART COOPER Professor and former CBE chairman, Ph.D. Princeton University. Polymer science and engineering, properties of polyurethanes and ionomers, blood-materials interactions, tissue engineering. Awards and Honors President of Sigma Xi since July 1, 2016. Will serve as Past President from June 30, 2018-July 1, 2019. Refereed Papers Heath, D. E. and S. L. Cooper, "The Development of Polymeric Materials Inspired by the Extracellular Matrix," J. Biomaterials Sci., Polymer Ed., 28, 1051-1069 (2017).
Stuart Cooper at the 2017 March for Science, Washington, D.C. Jeffrey Chalmers
LIANG-SHIH FAN
Distinguished University Professor, C. J. Easton Professor, Ph.D. West Virginia University. Fluidization, particle technology, environmental control technology, multiphase flow and reaction engineering Awards and Honors Distinguished Lectures • Centennial Technical Lecture, West Virginia University, Chemical Engineering Department, March 24, 2017. • Warren L. McCabe Lecture, North Carolina State University, Chemical Engineering Department, March 27, 2017. • ExxonMobil Distinguished Lecture, University of Massachusetts, Amherst, April 4, 2017. • Zhang Dayu Lecture, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, May 9, 2017. • The Ensor Lecture, Washington State University, March 26, 2018. • AIChE Ansys Particle Technology Forum Service Award, 2017. • Two sessions on “Fluidization and Fluid-Particle Systems - in Honor of Prof. L.-S. Fan” held at the AIChE Annual Meeting in Minneapolis, MN, October 29 – November 3, 2017 Plenary/Keynote Lectures at National or International Conferences • Mission Innovate invitee for Carbon Capture, Utilization and Sequestration, September 25-28, 2017. • Invited lecture, ENFL: Division of Energy and Fuels,
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254th National ACS meeting, Washington, DC, 2017. • Plenary Lecturer, Division of Energy and Fuels, 255th ACS National Meeting, New Orleans, LA, March 19, 2018.
Zhao, X.; Zhou, H.; Sikarwar, V.; Zhao, M.; Park, A.; Fennell, P.; Shen, L.; Fan, L.-S.; “Biomass-based chemical looping technologies: the good, the bad and the future,” Energy & Environmental Science, 10, 1885-1910 (2017).
Books and Book Chapters L.-S. Fan, “Chemical Looping Partial Oxidation: Gasification, Reforming and Chemical Syntheses,” Cambridge University Press, (2017).
Chung, C.; Pottimurthy, Y.; Xu, M.; Hsieh, T.-L.; Xu, D.; Zhang, Y.; Chen, Y.-Y.; He, P.; Pickarts, M.; Fan, L.-S.; Tong, A.; “Fate of sulfur in coal-direct chemical looping systems,” Applied Energy, 208, 678-690 (2017).
Andrew Tong and Liang Zeng, "Chemical Looping Lang Q.; Zhuo C.; Guo M.; Xu M.; Jonathan A. Fan; Fan L.-S; Technology for Fossil Fuel Conversion with In Situ CO2 “Impact of 1% lanthanum dopant on carbonaceous fuel redox Control,” Chapter 12 in Multiphase Reactor Engineering for reactions with an iron-based oxygen carrier in chemical Clean and Low-Carbon Energy Applications, edited by Yi looping processes,” ACS Energy Letters, 2, 70 (2017). Cheng, Fei Wei, Yong Jin, pp. 377-401, Wiley (2017). Kathe M.; Empfield A.; Sandvik P.; Zhang Y.; Blair E.; Fan Refereed Papers L.-S.; “Utilization of CO2 as a Partial Substitute for Methane Lang Q.; Zhuo C.; Guo M.; Xu M.; Jonathan A. Fan; Fan L.-S; Feedstock in Chemical Looping Methane-Steam Redox “Impact of 1% lanthanum dopant on carbonaceous fuel redox Processes for Syngas Production,” Energy & Environmental reactions with an iron-based oxygen carrier in chemical Science, 10, 1345-1349 (2017). looping processes,” ACS Energy Letters, 2, 70 (2017). Kathe, M.; Fryer, C.; P. Sandvik; F. Kong; Y. Zhang; A. Empfield; Chung, C.; Lang, Q.; Shah, V.; Fan, L-.S.; “Chemically Fan, L.-S.; “Modularization Strategy for Syngas Generation and physically robust, commercially-viable iron-based in Chemical Looping Methane Reforming Systems with composite oxygen carrier sustainable over 3000 redox CO2 as Feedstock,” AICHE J, 63(8). 3343-3360 (2017). cycles at high temperatures for chemical looping applications,” Energy & Environmental Science, 10, 2318- Nadgouda, S.; Kathe, M.; Fan, L.-S.; “Cold gas efficiency 2323 (2017). enhancement in a chemical looping combustion system using staged H2 separation approach,” International Rasel, R., Zuccarelli, C., Marashdeh, Q., Fan, L.S. and Teixeira, Journal of Hydrogen Energy, 42(8), 4751-4763 (2017). F.; “Towards Multiphase Flow Decomposition Based on Electrical Capacitance Tomography Sensors,” IEEE Sensors Kathe, M.; P. Sandvik; Fryer, C.; Kong. F.; Zhang, Y.; Grigonis, Journal, 10.1109/JSEN.2017.2687828 (2017). G.; Fan, L.-S.; “Coal refining chemical looping systems with CO2 as a co-feedstock for chemical syntheses,” Energy & Qin, L.; Guo, M.; Cheng, Z.; Xu, M.; Liu, Y.; Xu, D.; Fan, J.- Fuels, in press, doi: 10.1021/acs.energyfuels.7b02742 (2018). A.; Fan, L.-S; “Improved cyclic redox reactivity of lanthanum modified iron-based oxygen carriers in carbon monoxide Wang, D.; Xu, M.; Marashdeh, Q.; Straiton, B.; Tong, A.; chemical looping combustion,” Journal of Materials Fan, L.S.; “Electrical Capacitance Volumn Tomography for Chemistry A, 5, 20153-20160 (2017). Characterization of Gas-Solid Slugging Fluidization with Gerlgart Group D Particles under High Temperatures,” Industrial & Engineering Chemistry Research, in press, doi:
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10.1021/acs.iecr.7b04733 (2018). Hsieh, T.-L.; Zhang, Y.; Xu, D.; Wang, C.; Pickarts, M.; Chung, C.; Fan, L.-S.; Tong, A.; “Chemical looping gasification (CLG) for producing high purity, H2-rich syngas in a co-current moving bed reducer with coal and methane co-feeds,” Industrial & Engineering Chemistry Research, in press, doi: 10.1021/acs.iecr.7b04204 (2018). Cheng, Z.; Lang, Q.; Fan, J.-A.; Fan, L.-S.; “Metal oxide oxygen carriers for chemical looping process applications: A perspective,” Engineering, in press (2018). Grant Support $5,111,114 (2017-2018). PI L.-S. Fan; National Energy Technology Laboratory (NETL)/Ohio Development Services Agency: 10 MWe coal direct chemical looping large pilot plant – pre-front end engineering and design (pre-FEED) study. $3,328,314 (2014-2018). National Energy Technology Laboratory (NETL)/Ohio Development Services Agency: Pilot Scale Operation and testing of Syngas chemical looping for Hydrogen production. $3,050,000 (2016-2019). PI L.-S. Fan; National Energy Technology Laboratory (NETL)/Ohio Development Services Agency: Heat integration optimization and dynamic modeling investigation for advancing the coal direct chemical looping process. $2,700,000 (2015-2017). PI L.-S. Fan; National Energy Technology Laboratory (NETL)/Ohio Development Services Agency: Chemical looping coal gasification sub-pilot unit demonstration and economic assessment for IGCC applications. $2,000,000 (2016-2019). PI L.-S. Fan; Office of Energy Efficiency & Renewable Energy (EERE): Biomass gasification for chemicals production using chemical looping techniques.
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$200,000 (2016-2017). PI L.-S. Fan; Ohio Development Services Agency (ODSA): Study of Physical and chemical interactions between coal and oxygen carrier particles in the OSU coal-direct chemical looping process – Phase II.
Janani Sampath and Lisa M. Hall, “Impact of Ionic Aggregate Structure on Ionomer Mechanical Properties from Coarse-Grained Molecular Dynamics Simulations,” J. Chem. Phys., 147, 134901. Featured on the cover of the issue. (2017).
$200,000 (2016-2017). PI L.-S. Fan; SPONSOR: Technoeconomic analysis of the carbonation calcination reaction (CCR) process for CO2 capture from coal combustion power plants. $200,000 (2017-2018). PI L.-S. Fan; Ohio Development Services Agency (ODSA): Catalytic dopant in modified oxygen carriers for coal-direct chemical looping applications. HC Slip Slider Professorship and Assistant Professor, Ph.D. University of Illinois at Urbana-Champaign. Polymer physics, theory and simulation, statistical thermodynamics.
Thomas E. Gartner III, Tomohiro Kubo, Youngmi Seo, Maxym Tansky, Lisa M. Hall, Brent S. Sumerlin, and Thomas H. Epps, III, “Domain Spacing and Composition Profile Behavior in Salt-Doped Cyclic vs Linear Block Polymer Thin Films: A Joint Experimental and Simulation Study,” Macromolecules, 50, 7169–7176 (2017).
Refereed Papers Janani Sampath and Lisa M. Hall, “Effect of Neutralization on the Structure and Dynamics of Model Ionomer Melts,” Macromolecules, DOI: 10.1021/acs.macromol.7b02073, accepted (2017).
Jonathan R. Brown, Youngmi Seo, Scott W. Sides, and Lisa M. Hall, “Unique Phase Behavior of Inverse Tapered Block Copolymers: Self-Consistent Field Theory and Molecular Dynamics Simulations,” Macromolecules, 50, 5619–5626 (2017).
Jeffrey G. Ethier and Lisa M. Hall, “Modeling Individual and Pairs of Adsorbed Polymer-Grafted Nanoparticles: Structure and Entanglements,” Soft Matter, DOI: 10.1039/C7SM02116J (2017).
Ishan Prasad, Youngmi Seo, Lisa M. Hall, and Gregory M. Grason, “Intradomain Textures in Block Copolymers: Multizone Alignment and Biaxiality,” Phys. Rev. Lett., 118, 247801 (2017).
LISA HALL Patents • L.-S. Fan, D. Baser, M. Kathe, “Chemical Looping Systems for Conversion of Low- and No-Carbon Fuels to Hydrogen,” PCT/US2017/034503. • L.-S. Fan, M. Kathe, A. Empfield, C. Fryer, E. Blair, “Chemical Looping Syngas Production from Carbonaceous Fuels,” PCT/US2017/027241. • Marashdeh, Q.; Fan, L.-S.; Teixeira, F.; Zeeshan, Z.; “Active Control Guards and Rationmetric Calibration and Reconstruction for use with Electrical Capacitance Volume Tomography,” App. # 15/304,744 (2017). • Fan, L.-S.; “Adaptive Electrical Capacitance Volume Tomography,” PCT 14/988075 (2017).
Youngmi Seo, Jonathan R. Brown, and Lisa M. Hall, “Diffusion of Selective Penetrants in Interfacially Modified Block Copolymers from Molecular Dynamics Simulations,” ACS Macro Lett., 6, 375–380 (2017). Grant Support $475,000 (2015-Present). PI Lisa Hall; National Science Foundation CAREER: Modeling Polymer Electrolyte Microstructure: How Polymer Architecture Controls Ion Conduction. The above simulation of polymer-grafted nanoparticles can show the conditions under which the chains on adjacent particles entangle, making the material mechanically robust.
$342,000, OSU portion, (2015-Present). Co-PIs Thomas Epps III, University of Delaware; Lisa Hall, OSU; U.S.
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Department of Energy: Designing Efficient Nanostructured Polymer Electrolytes Using Tapered Block Polymers: Joint Experiment and Theory Effort in Controlled Interface Design.
9th China-U.S. Conference of Chemical Engineering, Beijing, China, October 15-19, 2017. Books and Book Chapters Z. Hao, Q. Li, W. S. W. Ho, and N. N. Li, “Liquid Membranes,” Chap. 2.14 in Comprehensive Membrane Science and Technology, Enrico Drioli, Lidietta Giorno, and E. Fontananova, eds., 2nd edition, Vol. 2, pp. 411-439, Elsevier, Oxford (2017).
$137,258 out of $299,816 (2015-Present). Co-PIs Vishnu Sundaresan, Lisa Hall; National Science Foundation: Thermoelectric Extrusion of Smart Structural Composites with Molecular Precision. $41,316 out of $1,174,126 (2013-2017). Co-PIs Jessica Winter, Barbara Wyslouzil, Lisa Hall, Carol Lynn Alpert; National Science Foundation SNM: Continuous, Large-Scale Nanocomposite Production Via Micellular Electrospray.
W.S. WINSTON HO $26,000 (2014-2016). Cooper Tire and Rubber Company, Ph.D. student support and professional development. $24,075 (2017). Air Force Office of Scientific Research, Summer Faculty Fellowship: Molecular Dynamics Simulations of Hairy Nanoparticle Assemblies on Surfaces. $7,870 out of $40,000 (2016-2017). PI Kurt Koelling, CoPI Lisa Hall; OSU Institute for Materials Research: Effects of Polymer Adsorption on Dynamics of Model Polymer Nanocomposites for Design of Advanced Tire Tread Compounds.
Hall Group outreach activity at a local high school.
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Distinguished Professor of Engineering, Ph.D. University of Illinois at Urbana. Molecularly-based membrane separations, fuel-cell fuel processing and membranes, transport phenomena in membranes, separations with chemical reaction, reverse osmosis.
Refereed Papers Z. Tong and W. S. W. Ho, “Facilitated Transport Membranes for CO2 Separation and Capture,” Sep. Sci. Technol., 52 (2), 156-167 (2017). Z. Jia, G. Wu, D. Wu, Z. Tong, and W. S. W. Ho, “Preparation of Ultra-Stable ZIF-8 Dispersions in Water and Ethanol,” J. Porous Mater., 24 (6), 1655-1660 (2017).
V. Vakharia, W. Salim, M. Gasda, and W. S. W. Ho, “Oxidatively Awards and Honors Stable Membranes for CO2 Separation and H2 Purification,” • Honorary International Chair Professor, Tianjin J. Membr. Sci., 533, 220-228 (2017). Polytechnic University, Tianjin, China, 2017-now. • Invited Visiting Professor, Beijing University of D. Wu, C. Sun, P. K. Dutta, and W. S. W. Ho, “SO2 Interference Chemical Technology, Beijing, China, 2017-now. on Separation Performance of Amine-Containing Facilitated • 2017 OSU IMR Innovation Award for Most Invention Transport Membranes for CO2 Capture from Flue Gas,” J. Disclosures Filed, Institute for Materials Research. Membr. Sci., 534, 33-45 (2017). • 2017 Accelerator Award, Office of Technology Commercialization, OSU. Z. Tong and W. S. W. Ho, “New Sterically Hindered • Tsinghua Forum on Chemical Engineering, “New Polyvinylamine Membranes for CO2 Separation and Amine-Containing Membranes for CO2 Capture”, Capture,” J. Membr. Sci., 543, 202-211 (2017). Tsinghua University, Beijing, China, May 22, 2017. • Invited Plenary Lecture, “New Amine-Containing Grant Support Membranes for H2 Purification and CO2 Capture”, $1,248,278 (2016-2019). PI W.S. Winston Ho; Department International Green Chemical Engineering Summit of Energy, National Energy Technology Laboratory (NETL): 2017 (IGCES 2017), Beijing, China, October 17, 2017. Novel CO2-Selective Membranes for CO2 Capture from <1% • Invited Keynote Lecture, “New Amine-Containing CO2 Sources. OSURF Project No. 60051153. Membranes for CO2 Capture”, Carbon Capture and Utilization Conference, National Taiwan University, $1,000,000 (2016-2018). PI W.S. Winston Ho; Ohio Taipei, Taiwan, May 15-17, 2017. Development Services Agency (ODSA): Novel Prototype • Invited Keynote Lecture, “New Amine-Based Membrane for CO2 Capture. OSURF Project No. 60051653. Facilitated Transport Membranes for CO2 Capture,”
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$950,104 (2015-2018). PI W.S. Winston Ho; Bloom Energy Corporation: Carbon Dioxide Removal for Solid Oxide Fuel Cell Systems – Phase IV: Quaternary Ammonium Hydroxide and Fluoride Membranes. OSURF Project No. 60047812. $324,828 (2017-2018). PI W.S. Winston Ho; Bloom Energy Corporation: Carbon Dioxide Removal for Solid Oxide Fuel Cell Systems – New CO2-Selective Membranes. OSURF Project No. 60062277.
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$218,031 (2014-2018). PI W.S. Winston Ho; Bloom Energy Corporation: Carbon Dioxide Removal for Solid Oxide Fuel Cell Systems. OSURF Project No. 60037842. $80,000 out of $240,000 (2016-2018). PI Junhang Dong, Co-PI Peter Smirniotis, both at the University of Cincinnati; Co-PI W.S. Winston Ho; Ohio Development Services Agency (ODSA): Integrating H2 Permselective WGS Membrane Reactor with CO2 Membrane Separator for Efficient PreCombustion Carbon Capture. OSURF Project No. 60051649. $75,000 out of $150,000 (2016-2017). PI Raghuvir Singh, ITN Energy Systems, Inc.; Co-PI W.S. Winston Ho; Department of Energy STTR Program: Economical Self-Powered Portable Clean Energy Desalination System. OSURF Project No. 60054101. Patents • W. S. W. Ho, P. K. Dutta, K. Ramasubramanian, and M. A. Severance, “Composite Membranes for Separation of Gases,” U.S. Patent Application No. 15/327,832 (filed January 20, 2017); U.S. Patent Application Public. No. US 2017/0209838-A1 (July 27, 2017). • M. Gasda, A. Ballantine, C. Karuppaiah, and W. S. W. Ho, “Carbon Dioxide Separator, Fuel Cell System Including Same, and Method of Operating Fuel Cell System,” European Patent Application No. 16747183.8 (filed September 12, 2017). • W. S. W. Ho and Y. Han, “Methods for the Separation of CO2 from a Gas Stream,” U.S. Patent Application No. 15/577,951 (filed November 29, 2017); PCT Patent
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Application No. PCT/US2016/033757 (filed May 23, 2016). W. S. W. Ho, W. Salim, and V. Vakharia, “Membranes for Gas Separation,” U.S. Patent Application Publication No. US 2017/0056839 A1 (March 2, 2017); U.S. Patent Application No. 15/254,242 (filed September 1, 2016); U.S. Provisional Patent Application No. 62/212,699 (filed September 1, 2015). W. S. W. Ho, W. Salim, and V. Vakharia, “Membranes for Gas Separation”, PCT Patent Application International Publication No. WO 2017/040761 A1 (March 9, 2017); PCT Patent Application No. PCT/US 2016/049868 (filed September 1, 2016); U.S. Provisional Patent Application No. 62/212,699 (filed September 1, 2015). W. S. W. Ho and Y. Chen, “Polymeric Membranes for Separation of Gases”, U.S. Patent Application No. 15/577,954 (filed November 29, 2017); PCT Patent Application No. PCT/US2016/035035 (filed May 31, 2016. W. S. W. Ho, V. Vakharia, and W. Salim, “BorateContaining Membranes for Gas Separation”, U.S. Provisional Patent Application No. 62/416,434 (filed November 2, 2016); PCT Patent Application No. PCT/ US2017/059505 (filed November 1, 2017). W. S. W. Ho and Y. Han, “Membranes for Gas Separation” (CNT), U.S. Provisional Patent Application No. 62/548,195 (filed August 21, 2017). W. S. W. Ho and D. Wu, “Membranes for Gas Separation” (PES), U.S. Provisional Patent Application No. 62/548,205 (filed August 21, 2017). W. S. W. Ho, W. Salim, and V. Vakharia, “SpiralWound Membrane Module for Gas Separations and Associated Methods,” U.S. Provisional Patent Application No. 62/557,477 (filed September 12, 2017).
L. JAMES LEE Professor and Kurtz Chair holder, Ph.D. University of Minnesota. Polymer and composite engineering, micronanotechnology, BioMEMS/NEMS. Awards and Honors Foreign Master Professorship, Technology, China.
Dalian
University
of
Books and Book Chapters E. Carrera, J.M. Castro, A.Y. Yi and L.J. Lee, “Microinjection Molding,” Chapter 12 in Advanced Injection Molding Technologies edited by L.T. Turng and S-C Chang, Hanser Publication, in press. Refereed Papers Gallego-Perez D, Pal D, Ghatak S, Malkoc V, HiguitaCastro N, Gnyawali S, Chang L, Liao WC, Shi J, Sinha M, Singh K, Steen E, Sunyecz A, Stewart R, Moore J, Ziebro T, Northcutt RG, Homsy M, Bertani P, Lu W, Roy S, Khanna S, Rink C, Sundaresan VB, Otero JJ, Lee LJ and Sen CK. “Topical tissue nano-transfection mediates non-viral stroma reprogramming and rescue,” Nature Nanotechnology, 12(10):974-979 (2017). Hu J, Sheng Y, Kwak KJ, Shi J, Yu B, Lee LJ. “A signalamplifiable biochip quantifies extracellular vesicleassociated RNAs for early cancer detection,” Nature
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Communication, 8(1):1683 (2017). Baldwin S, Deighan C, Bandeira E, Kwak KJ, Rahman M, Nana-Sinkam P, Lee LJ, Paulaitis ME. “Analyzing the miRNA content of extracellular vesicles by fluorescence nanoparticle tracking,” Nanomedicine, 13(2):765-770 (2017). Chiang CL, Goswami S, Mani R, Frissora F, Xie Z, Huang X, Baskar S, Rader C, Phelps MA, Marcucci G, Byrd JC, Lee LJ and Muthusamy N. “Tumor antigen ROR1 targeted delivery of miR-29b in chronic lymphocytic leukemia induces epigenetic reprograming resulting in cell cycle arrest,” Blood, 130 (Suppl 1), 4981-4981 (2017). Shen Q, Yasmeen R, Marbourg J, Xu L, Yu L, Fadda P, Flechtner A, Lee LJ, Popovich PG, Ziouzenkova O. “Induction of innervation by encapsulated adipocytes with engineered vitamin A metabolism,” Transl Res, pii: S19315244(17)30288-8 (2017). Durrani-Kolarik S, Pool CA, Gray A, Heyob KM, Cismowski MJ, Pryhuber G, Lee LJ, Yang Z, Tipple TE, Rogers LK. “MiR-29b supplementation decreases expression of matrix proteins and improves alveolarization in mice exposed to maternal inflammation and neonatal hyperoxia,” Am J Physiol Lung Cell Mol Physiol, 1;313(2):L339-L349 (2017). Sheng Y, Hu J, Shi J, Lee LJ. “Stimuli-responsive carriers for controlled intracellular drug release,” Curr Med Chem, doi: 10.2174/0929867324666170830102409 (2017).
Grant Support $2.75M (2017-2022). Co-PI L. James Lee (45%); NIH U01 CA213330: Extracellular Vesicles in Small Cell Lung Cancer Early Detection. $2.2M (2014-2018). Co-PI L. James Lee (60%). Ohio Third Frontier Program: Carbon Nanomaterials and Composites Platform. $1.8M (2015-2020). Co-PI L. James Lee (2%); NIH R01 CA190740-02: Molecular Mechanisms of Cachexia in Lung Cancer. $1.6M (2017-2020). Co-PI L. James Lee (50%). NIH R33 CA225380-01: Molecular Beacon Based Extracellular mRNA and Protein Detection for Early Cancer Diagnosis. $422,500 (2016-2018). Co-PI L. James Lee (2%); NIH R21 NS099869: Nanotechnology-based Non-viral Derivation of Induced Endothelium for Ischemic Disorders. $35,000 (1997-2018). PI L. James Lee, Owens Corning industrial membership fees, Center for Advanced Polymer and Composite Engineering. Patents L.J. Lee, P. Boukany, J. Guan and N. Chiou, “Dose and Location Controlled Drug /Gene/Particle Delivery to Individual Cells by Nanoelectroporation,” U.S. Patent 9,816,086, November 14 (2017).
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Refereed Papers Yang, C.-T., Janda, A., Bell, A.T.* & Lin, L.-C.*, “Atomistic Investigations of the Effects of Si/Al Ratio and Al Distribution on the Adsorption Selectivity of n-Alkanes in Brønsted-Acid Zeolites,” J. Phys. Chem. C, in press (2018). Will be featured as the cover of a future issue. Cho, J.W., Lin, L.-C.*, & Grossman, J.C.*, “The Role of Structural Defects in the Water Adsorption Properties of MOF-801,” J. Phys. Chem. C, in press (2018). Van der Mynsbrugge, J.; Janda, A.; Lin, L.-C.; Van Speybroeck, V.; Head-Gordon, M. & Bell, A.T., “Understanding BrønstedAcid Catalyzed Monomolecular Reactions of Alkanes in Zeolite Pores by Combining Insights from Experiment and Theory,” ChemPhysChem, in press, (2018). Will be featured as the cover of a future issue and highlighted in the cover profile.
Wang X, Zhi X, Yang Z, Tian H, Li Y, Li M, Zhao W, Zhang C, Wang T, Liu J, Shen D, Zheng C, Zhao D, Yang S, Qi J, Xin H, Stojadinovic A, Avital I, Lee LJ, Rao J, Zhang W. “A novel serum based biomarker panel has complementary ability to preclude presence of early lung cancer for low dose CT (LDCT),” Oncotarget, 8(28):45345-45355 (2017). Chang L, Chen F, Zhang X, Kuang T, Li M, Hu J, Shi J, Lee LJ, Cheng H, Li Y. “Synthetic melanin e-Ink,” ACS Appl Mater Interfaces, 9(19):16553-16560 (2017).
LI-CHIANG LIN Assistant Professor, Ph.D. University of California-Berkeley. Discovery of novel, energy-efficient, cost-effective materials using computational approaches for energyrelated applications such as separations.
Jim Lee’s innovation, Tissue Nanotransfection (TNT), a nearly painless procedure, shows promise in healing damaged tissue.
Deshpande, N., Pattanaik, L., Whitaker, M.W., Yang, C.-T., Lin, L.-C., Brunelli, N.A. “Selectively Converting Glucose to Fructose Using Immobilized Tertiary Amines,” Journal of Catalysis 353, 205-210 (2017).
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Lin, L.-C., Paik, D. & Kim, J. “Understanding Gas Adsorption in MOF-5/Graphene Oxide Composite Material,” Phys. Chem. Chem. Phys. 19, 11639-11644 (2017). Jamali, S.H., Vlugt, T.J.H & Lin, L.-C.*, “Atomistic Understanding of Zeolite Nanosheets for Water Desalination,” J. Phys. Chem. C 121, 11273-11280 (2017). Featured as the cover of the issue and selected as the ACS Editors’ Choice.
ANDREW MAXSON
UMIT S. OZKAN
Clinical Assistant Pofessor, Ph.D. The Ohio State University. Drag reduction.
College of Engineering Distinguished Professor, Ph.D. Iowa State University. Catalysis, electro-catalysis and catalytic materials. Application of catalysis in the areas of energy conversion and emission control.
Van der Mynsbrugge, J.; Janda, A.; Mallikarjun Sharada, Books and Book Chapters S.; Lin, L.-C.; Van Speybroeck, V.; Head-Gordon, M. & Bell, Zakin, J. L., Maxson, A. J., Saeki, T., & Sullivan, P. F. A., “Theoretical Analysis of the Influence of Pore Geometry “Turbulent Drag-reduction Applications of Surfactant on Monomolecular Cracking and Dehydrogenation of Solutions” in Wormlike Micelles: Systems, Characterization n-Butane in Brønsted-Acid Zeolites,” ACS Catalysis 7, 2685- and Applications, C. Dreiss, Y. Feng (Eds.), Royal Society of 2697 (2017). Chemistry (pp. 353-378) (2017). Janda, A., Vlaisavljevich, B., Smit, B., Lin, L.-C.* & Bell, A.T.*, “Effects of Zeolite Pore and Cage Topology on Thermodynamics of n-Alkane Adsorption at Brønsted Protons in Zeolites at High Temperature,” J. Phys. Chem. C 121, 1618-1638 (2017).
Refereed Papers Maxson, A., Watson, L., Karandikar, P., & Zakin, J.,”Heat transfer enhancement in turbulent drag reducing surfactant solutions by agitated heat exchangers.” International Journal of Heat and Mass Transfer, 109, 1044-1051 (2017).
Becker, T., Heinen, J., Dubbeldam, D., Lin, L.-C. & Vlugt, T., “Polarizable Force Fields for CO2 and CH4 Adsorption in M-MOF-74,” J. Phys. Chem. C 121, 4659-4673 (2017).
Patents Provisional patent 62/591,822: Self-Assembly of Telechelic Polyisobutylene Polymers for Drag Reduction.
Liou, K.-H., Kang, D.-Y.*, and Lin, L.-C.*, “Investigating the Potential of Single-walled Aluminosilicate Nanotubes in Water Desalination,” ChemPhysChem 18, 179-183 (2017). Featured as the back cover of the issue. Grant Support 7,500,000 CPU-hours (two grants of computation time) - LiChiang Lin, PI; Ohio Supercomputing Center.
Awards and Honors • 2017 ACS Energy and Fuels Division, Henry H. Storch Award; first woman to receive the award in its 53-year history. • Honored by a special two-day award symposium in recognition of the 2017 Storch Award she received from the ACS Energy and Fuels Division. The symposium was part of the 254th American Chemical Society National Meeting held in Washington DC. It was organized by Elizabeth Biddinger (a chemical engineering professor at City College of New York and an alumnus of the Ozkan research group) and Professor Nick Brunelli of OSU. There were 28 invited speakers from 18 different universities, six national laboratories and three companies, including seven former Ph.D. students of Professor Ozkan. • Special volume of Catalysis Today to honor Professor Ozkan (to be published in 2018). Books and Book Chapters Mamtani, K. Ozkan, U.S., “Nitrogen-doped Carbon Nanostructures as Oxygen Reduction Reaction (ORR) and Oxygen Evolution Reaction (OER) Electrocatalysts in Acidic
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Media,” in Handbook on the Graphene Materials, WileyScrivener, USA. In press. Refereed Papers Sinha Majumdar, S., Alexander, A-M., Celik, G., Gawade, P., Ozkan, U.S., “In-situ incorporation of binder during sol-gel preparation of Pd-based sulfated zirconia for reduction of nitrogen oxides under lean-burn conditions: Effect on activity and wash-coating characteristics,” Applied Catalysis B. 202, 134-146 (2017). Sohn, H., Celik, G., Gunduz, S., Dean, S.L., Painting, E., Paul L. Edmiston, P.L., and Ozkan, U.S., “Hydrodechlorination of Trichloroethylene over Pd Supported on Swellable Organically-Modified Silica (SOMs).” Applied Catalysis, B. 203, 641-653 (2017). Sohn, H., Celik, G., Gunduz, S., Sinha Majumdar S., Dean, S.L, Edmiston, P.L., and Ozkan, U.S.,”Effect of High-temperature on the Swellable Organically-Modified Silica (SOMS) and Its Application to Gas-Phase Hydrodechlorination of Trichloroethylene,” Applied Catalysis B.209, 80-90 (2017). Mamtani, K., Jain, D, Shankaran, K., Co, A., Ozkan, U.S., “Nitrogen-coordinated iron-carbon (FeNC) Materials as Efficient Bifunctional Electrocatalysts for Oxygen Reduction Reaction and Oxygen Evolution Reaction in Acidic Media,” Energy and Fuels, 31(6), 6541–6547 (2017). Mamtani, K., Jain, D., Co, A., Ozkan, U.S., “Investigation of Chloride poisoning for Carbon-based Materials as Oxygen Depolarized Cathode Catalysts in Acidic Media,” Catalysis Letters. 147(11), 2903-2909. DOI 10.1007/s10562-017-22053 (2017). Mamtani, K., Bruening, C., Co, A., Ozkan, U.S., “A Comparison of Oxygen Reduction Reaction (ORR) Performance for Ironnitrogen-carbon (FeNC) Catalysts in Acidic and Alkaline Media,” Research & Reviews in Electrochemistry 8(2)1-9 (2017).
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Sohn, H., Celik, G., Gunduz, S., Dogu, Zhang, S., Shan, J., (Feng) Tao,F., and Ozkan, U.S., “Oxygen Mobility in Prereduced Nano- and Macro-ceria with Co loading: An APXPS, in-situ DRIFTS and TPR Study,“ Catalysis Letters, 147:2863–2876 (2017).
$165,000 (2016-2017). HONDA North America, Inc.: Catalytic reforming of VOCs generated during paint operations. $160,000 (2015-2017). Ohio Coal Development Office: Production of functionalized carbon-nanostructures from coal gas.
Sinha Majumdar, S., Alexander, A.-M., Gawader, P., Celik, G., Ozkan, U.S., “Sulfur-tolerance of the dual-catalyst aftertreatment system for reduction of nitrogen oxides under lean conditions,” Catalysis Today. doi.org/10.1016/j. cattod.2018.01.027 Dogu, D., Meyer K. E., Fuller A., Gunduz. S., Deka, D.J., Kramer, N., Co, A.C., Ozkan, U.S.,”Effect of Lanthanum and Chlorine Addition on Strontium Titanates for Electrocatalytically-Assisted Oxidative Dehydrogenation of Ethane,” Accepted. Applied Catalysis B. https://doi. org/10.1016/j.apcatb.2018.01.019 (2018). Mamtani, K., Jain, D., Dogu, D., Gustin, V., Gunduz, S., Co, A., Ozkan, U.S., “Insights into Oxygen Reduction Reaction (ORR) and Oxygen Evolution Reaction (OER) Active Sites for Nitrogen-doped Carbon Nanostructures (CNx) in Acidic Media,” Applied Catalysis B.220, 88-97 https://doi. org/10.1016/j.apcatb.2017.07.086 (2018). Grant Support $704,000 (2016-2019). PI Robert Baker, co-PIs: Umit Ozkan, Anne Co, Yiying Wu, Nick Brunelli; National Science Foundation: MRI: Acquisition of X-ray photoelectron spectrometer for discovering new phenomena with in situ studies. $625,000 (2017-2020). PI Umit Ozkan, Co-PIs Anne Co, Aravind Asthagiri. DOE-BES: Tailoring the active sites in hetero-atom doped carbon catalysts for oxygen reduction and oxygen evolution reactions.
ANDRE PALMER Professor and Chair, Ph.D. Johns Hopkins University. Bioengineering and biomaterials for transfusion medicine. Awards and Honors • Member, Bioengineering, Technology, and Surgical Sciences (BTSS) study section, NIH • Student Richard Hickey: 2017 NSF Graduate Research Fellowship Refereed Papers J. J. Chalmers, X. Jin, A. F. Palmer, P. Amaya, M. H. Yazer, L. R. Moore, K. J. Park, X. J. Pan, M. Zborowski, “Femtogram resolution of iron content on a per cell basis: ex vivo storage of human red blood cells leads to loss of hemoglobin,” 89: 3702-3709 Analytical Chemistry (2017).
V. P. Jani, J. Alborz, S. Moges, P. Nacharaju, C. Roche, $362,520 (2014-2018). National Science Foundation: D. Dantsker, A. Palmer, J. M. Friedman, P. Cabrales, GOALI: Swellable superhydrophobic organosilica materials “Polyethylene glycol camouflaged earthworm hemoglobin,” as a novel catalyst support for water purification systems. Jan 18;12(1):e0170041. doi: 10.1371/journal.pone.0170041. PLoS One (2017).
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I. Pires, D. Belcher, A. F. Palmer, “Quantification of Active Apohemoglobin Heme Binding Sites via Dicyanohemin Incorporation," 56: 5245-5259 Biochemistry (2017). D. A. Belcher, U. Banerjee, C. M. Baehr, K. E. Richardson, P. Cabrales, F. Berthiaume, A. F. Palmer, “Mixtures of tense and relaxed state polymerized human hemoglobin regulate oxygen affinity and tissue construct oxygenation,” Oct 11;12(10):e0185988. doi: 10.1371/journal.pone.0185988. PLoS One (2017). D. A. Belcher, J. A. Ju, J. H. Baek, A. Yalamanoglu, P. W. Buehler, D. M. Gilkes, and A. F. Palmer, “The quaternary state of polymerized human hemoglobin regulates oxygenation of breast cancer solid tumors: a theoretical and experimental study,” accepted PLoS One (2018). Grant Support $1,507,222 (2016-2020). PI Andre F. Palmer, Co-PI P. Cabrales; National Institutes of Health Grant R01HL126945: Attenuating the oxidative and myocardial side-effects of acellular hemoglobin. $1,392,552 (2016-2020). PI Andre F. Palmer, Co-PI F. Berthiaume; National Institutes of Health Grant: R01EB021926: Polymerized hemoglobins for facilitated oxygen transport in hepatic bioreactors. $2,670,860 (2017-2020). PI Jeffrey Chalmers, Co-PI Andre F. Palmer and M. Zborowski. National Institutes of Health Grant R01HL131720: Fractionation of aged RBCs based on hemoglobin content. $2,875,118 (2017-2021). PI Andre F. Palmer, Co-PIs P. Cabrales, P. Kaumaya. National Institutes of Health Grant R01HL138116: PEGylated megahemoglobin for use as a red blood cell substitute. $2,460,698 (2018-2022). PI Andre F. Palmer, Co-PI P. Cabrales. U.S. Army Medical Research And Materiel Command: Next generation polymerized hemoglobins for use in transfusion medicine.
JAMES RATHMAN Professor, Ph.D. University of Oklahoma. Molecular informatics, computational modeling for safety/risk assessment, analysis of large chemical and biological datasets.
EDUARDO REÁTEGUI Assistant Professor, Ph.D. University of Minnesota. Microtechnologies, biomaterials, spectroscopy, immunoengineering, circulating biomarkers. Refereed Papers
Book Chapter J Rathman, C Yang, A Tarkhov, O Sacher, T Kleinoeder, J Marusczyk, D Mehta, C Schwab, B Bienfait, “Role of chemoinformatics in regulatory science,” Chapter 8 in Chemoinformatics, J Gasteiger & T Engels Ed. Wiley, In press.
This article was highlighted in News and Views from Nature Biomedical Engineering. The paper was also highlighted in Behind the Paper from Nature Biomedical Engineering.
E. Reátegui*, K. van der Vos*, C. P. Lai*, M. Zeinali, N. A. Atai, B. Aldikacti, F. P. Floyd, A. Khankhel, V. Thapar, F. H. Hochberg, L.V. Sequist, B. V. Nahed, B. Carter, M. Toner, L. Balaj, D. Ting, X. O. Breakefield, S. L. Stott, “Engineered Nanointerfaces for Microfluidic Isolation and Molecular Profiling of Tumorspecific Extracellular Vesicles,” Nature Communications, 9, (1), 175 (2018). *Equal Contribution. E. Reátegui, F. Jalali, A. Khankhel, E. Wong, H. Cho, J. Lee, C. N. Serhan, J. Dalli, H. Elliott, D. Irimia, “Microscale Array for the Profiling of Start and Stop Signals Coordinating Humanneutrophil Swarming,” Nature Biomedical Engineering, 1, 0094 (2017).
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R. Vogel, A. K. Pal, S. Jambhrunkar, P. Patel, S. S. Thakur, E. Reátegui, H. S. Parekh, P. Saáz, A. Stassinopoulos, M. Broom, “High-throughput Single Particle Zeta Potential Characterization of Biological Nanoparticles using Tunable Resistive Pulse Sensing.” Scientific Reports, 7, (1), 17479 (2017).
Therapeutics for Central Nervous System Injury. Patents Joseph C. Salamone, Xiaoyu Chen-Leung, Ann B. Salamone, Katelyn E. Reilly, “Compositions for Enzymatic Debridement,” U.S. 9,592,280. March 14, 2017.
X. Jiang, K. H. K. Wong, A. H. Khankhel, M. Zeinali, E. Reátegui, M. J. Phillips, X. Luo, N. Aceto, F. Fachin, A. N. Hoang, W. Kim, A. E. Jensen, Lecia V. Sequist, S. Maheswaran, D. A. Haber, S. L. Stott, M. Toner, “Microfluidic Isolation of Plateletcovered Circulating Tumor Cells, Lab on a Chip, 17, 34983503 (2017). J. Preciado*, E. Reátegui*, S. Azarin, E. Lou, A. Aksan, “Immobilization Platform to Select and Induce Quiescence of Dormancy-capable Cancer Cells.” In press Technology, 5, (3), 129-138 (2017). *Equal Contribution. M.-H. Park*, E. Reátegui*, W. Li, S. N. Tessier, K. Wong, A. E. Jensen, M. Toner, S. L. Stott, P. T. Hammond, “Enhanced Isolation and Release of Circulating Tumor Cells Using Nanoparticle Binding in and Ligand Exchange in a microfluidic chip,” Journal of the American Chemical Society (JACS), 139, (7), 2741-2749 (2017). *Equal contribution. J. J. Kim, K. W. Bong, E. Reátegui, D. Irimia, P. S. Doyle, “Porous Microwells for Geometry Selective, Large-scale Microparticle Arrays,” Nature Materials, 16, 139-146 (2017). J. J. Kim*, E. Reátegui*, A. Hopke, F. Jalali, M. Roushan, P. S. Doyle, D. Irimia, “High-throughput Patterning of Living Colloids for Dynamic Studies of Neutrophil-Microbe Interactions.” In review, Small (2018). *Equal Contribution. Patents E. Reátegui, L. Kasinkas, L. Wackett, A. Aksan, M. Sadowsky, Silica-Encapsulated Biomaterials. U.S. Patent 9790484, 2017.
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KATELYN SWINDLE-REILLY Assistant Professor, Ph.D. Washington University-St. Louis. Optimized design of biomimetic polymeric biomaterials for applications in ophthalmology and wound healing. Awards and Honors Ohio Lions Eye Research Foundation, 2017 Lois Hagelberger Huebner Young Investigator Award. Grant Support $214,000 (2017-2019). PI Katelyn E. Swindle-Reilly, Co-PI; Matthew P. Ohr; Ohio Lions Eye Research Foundation Lois Hagelberger Huebner Young Investigator Grant: Sustained Release Bevacizumab Injectable for the Treatment of Wet Age-Related Macular Degeneration. $2,000 (2018). PI Heather L. Chandler, Co-PIs Derek J. Hansford, Katelyn E. Swindle-Reilly; OSU Institute for Materials Research Facility: Evaluating Micropatterning to Control Ocular Cell Behavior.
DAVID TOMASKO Professor, Ph.D. University of Illinois Urbana-Champaign. Molecular thermodynamics, supercritical fluid processing, polymer processing, engineering education. Grant Support $614,775 (2013-2017). PI David Tomasko, Co-PI Howard Greene. National Science Foundation, DUE-1259709, Project 60042813: Human Connect: Scholarships in science, technology, engineering and math.
$2,000 (2017). PI Katelyn E. Swindle-Reilly; OSU Institute for Materials Research Facility: Characterization of Amphiphilic Polymer Films for Controlling Cell Attachment. $1,000,000 (2015-2019). PI Matthew A. Reilly, Co-PI Katelyn E. Swindle-Reilly; DOD Vision Translational Research Program: Torsional Indirect Traumatic Optic Neuropathy (TITON): Animal Model for Diagnostics, Drug Delivery, and David Tomasko as Joe Koffolt.
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$160,000 (OCDO) and $40,000 (OSU) (2018-2020). Co-PI Andrew Tong, OCDO/OSU: Fate of Sulfur from Bituminous Coal in the Coal Direct Chemical Looping Process. This project does not allow the PI to directly charge to the sponsor or cost share release time of a clinical appointment.
Numbers: 60049959: Effect of Coal Mineral Matter on Oxygen Cycle in the Ohio State Coal Direct Chemical Looping Process.
$160,000 (OCDO) and $40,000 (OSU) (2018-2020). PI Liang-Shih Fan (5%), Andrew Tong (Grant Support); OCSO/ OSU: Fluidization and Distribution Characteristic Studies of Coal Particles in Packed Moving-Bed of Oxygen Carrier Particles for the Coal Direct Chemical Looping System.
ANDREW TONG Research Assistant Professor, Ph.D. The Ohio State University. Process development of advanced combustion and clean energy systems, gas-solid fluidization. Refereed Papers Chung, C., Pottimurthy Y., Xu M., Hsieh T,-H., Xu D., Zhang Y., Chen Y.-Y., He P., Pickarts M., Fan L.-S., Tong, A. Fate of sulfur in coal-direct chemical looping systems. Applied Energy (2017). Hsieh, T.-H., Zhang Y., Xu D., Wang C., Pickarts M., Chung C., Fan, L.-S., Tong A., Zeng L. Chemical Looping Gasification for Producing High Purity, H2-Rich Syngas in a Cocurrent Moving Bed Reducer with Coal and Methane Cofeeds. Industrial & Engineering Chemistry Research (2017). Wang D., Xu M., Marashdeh Q., Straiton B., Tong A., Fan L.-S., Electrical Capacitance Volume Tomography for Characterization of Gas–Solid Slugging Fluidization with Geldart Group D Particles under High Temperatures. Industrial & Engineering Chemistry Research (2017). Grant Support $741,194 (NETL/DOE) and $188,333 (OSU and B&W) (20182019). Co-PIs L.-S. Fan (5%), Andrew Tong (0%), National Energy Technology Laboratory (NETL)/Ohio Development Services Agency: 10 MWe CDCL Large Pilot Plant Demonstration - Phase I Feasibility.
$1,500,000 (NETL/DOE) and $1,500,000 (OCDO/State) (2016-2019). PI Andrew Tong (12%), Co-PI L.-S. Fan (5%); Federal Funds matched with State, OSURF Project Numbers: 60056251 and 60058190: Heat Integration Optimization and Dynamic Modeling Investigation for Advancing the Coal Direct Chemical Looping Process. $1,500,000 (DOE), $100,000 (OSU Fellowships and PI Release Time), $300,000 (in-kind from industrial partners) ((2017-2019). PI L.-S. Fan (5%), Co-PI Andrew Tong (10%), DOE etc., OSURF Project Number: 60054610, 60057311, 60057312, 60057727: Biomass Gasification for Chemicals Production Using Chemical Looping Techniques. $1,450,000 (OCDO/State) and $3,330,000 (in-kind from Babcock & Wilcox) (2017-2019). PI and/Or Co-PI L.-S. Fan (5%), Co-PI Andrew Tong (10%), OCDO/State of Ohio, OSURF Project Number: 60057802, 60054818: 10 MWe Coal Direct Chemical Looping Large Pilot Plant – Front End Engineering and Design (FEED) Study. $160,000 (OCRC/State) and $40,000 In-Kind from PI’s release time (2017-2018). PI and/or Co-PI Andrew Tong (10%), Co-PI Dawei Wang (10%), OCRC/State: Scale-Up Characteristics of a Fluidized Bed Combustor Reactor for Coal Direct Chemical Looping System: Cold Flow Model and Heat Transfer Studies. $160,000 and $40,000, OSU (Tong’s release time) (20162017), PI and/or Co-PI Andrew Tong (8%), OSURF Project
JESSICA O. WINTER Professor, Ph.D. University of Texas Bionanotechnology, cancer, drug delivery.
at
Austin.
Awards and Honors • Coalition for National Science Funding (NSF-invited Congressional presenter) • Dean’s Award for Distinguished Outreach Achievement. • AICHE leadership positions: Appointed MemberChemical Engineering Technical Operating Council (CTOC); Past-Chair- Nanoscale Science and Engineering Forum (NSEF). Books and Book Chapters Thomas Mensah, Ben Wang, Virginia Davis, Jessica Winter, Eds., Nanotechnology Commercialization: Manufacturing Processes and Product, Wiley (2017). DNA origami “hinge” with gold nanoparticle closure. Winter and collaborator Carlos Castro (MAE) are developing tiny nanomachines that can harvest and store energy from the external environment.
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G. Nabar, M. Souva, K.H. Lee, S. De, J. Lutkenhaus, B. Wyslouzil, J.O. Winter. “Chapter 3: Scalable Nanomanufacturing of Nanocomposites Using SprayBased Approaches,” Thomas Mensah, Ben Wang, Virginia Davis, Jessica Winter, Eds., Nanotechnology Commercialization: Manufacturing Processes and Product, Wiley (2017). Refereed Papers G.M. Nabar; K.D. Mahajan, M. Calhoun, A.D. Duong, M. Souva; J. Xu, C. Czeisler, V. Puduvalli, J.J. Otero, B.E. Wyslouzil, J.O. Winter (2018), “Micelle-Templated, Poly(lactic-coglycolic acid) Nanoparticles for Hydrophobic Drug Delivery,” International Journal of Nanomedicine, 13 351–366. [DOI: https://doi.org/10.2147/IJN.S142079] (2018).
B. Kaya, E. Goceri, F.S. Abas, B. Elder, V. Puduvalli, J. Winter, M. Gurcan, J.J. Otero, “Automated fluorescent miscroscopic image analysis of PTBP1 expression in glioma,” PLoS One, 12(3): e0170991. [doi:10.1371/journal.pone.0170991, PMCID: PMC5345755 (2017). Grant Support $17.9M (2014-2020). PI Chris Hammel, National Science Foundation, DMR-1420451: Materials Research Science and Engineering Center, Center for Emergent Materials. $1.2M (2017-2019). PI Jessica Winter, Co-PIs Carlos Castro, Ezekiel Johnston-Halperin, Michael Poirier, Department of Energy DE-SC0017270: Exploring Fundamental Properties of Dynamic DNA Origami-Nanoparticle Composites.
K.D. Mahajan, Y. Cui, C.J. Dorcena, N. Bouxsein, G.D. Bachand, J.J. Chalmers, J.O. Winter, “Magnetic Quantum Dots Steer and Detach Microtubules from Kinesin-Coated Surfaces,” Biotechnology Journal, 13, 1700402. [PMID: 28941258, DOI: 10.1002/biot.201700402] (2018).
$1,174,126 (2013-2017). PI Jessica Winter, Co-PIs Barbara Wyslouzil, Carol Lynn Alpert (Museum of Science, Boston), Lisa Hall, National Science Foundation CMMI-1344567, SNM: Continuous, Large-Scale Nanocomposite Production Via Micellular Electrospray.
M.S. Souva, G.M. Nabar, J.O. Winter, B.E. Wyslouzil, “Morphology of block copolymer micelles formed via electrospray enabled interfacial instability.” Journal of Colloids and Interface Science, 512, 411-418. [DOI: https:// doi.org/10.1016/j.jcis.2017.10.087] (2018).
$196,440 of $728,000 (2016-2019). PI Peter Kner, CoPIs Jessica Winter , Carol Lynn Alpert, National Science Foundation IDBR, DBI-1555470: Collaborative Research: IDBR Type A: QSTORM-AO-Wavefront-shaping lightsheet microscopy with photoswitchable quantum dots for superresolution imaging in thick tissue.
K.D. Mahajan, G.M. Nabar, W. Xue, M. Anghelina, N. Moldovan, J. Chalmers, J. Winter, ”Mechanotransduction Effects on Endothelial Cell Proliferation via CD31 and VEGFR2: Implications for Immunomagnetic Separation.” Biotechnology Journal, 12(9): 1600750 (2017). Short, C. Czeisler, B. Stocker†, S. Cole, J. Otero, J.O. Winter, “Imaging Cell-Matrix Interactions in Three-Dimensional Collagen Hydrogel Culture Systems.” Macromolecular Bioscience, 17(6): 1600478. [doi: 10.1002/mabi.201600478] (2017).
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Glioma brain cancer cells (green) cultured in microwells of collagen (red). Winter’s group is using these models to study cancer cell invasion in the brain.
$36,059 (2018). PI Qirui Fan, subcontractor Jessica Winter, National Science Foundation, IIP: Magnetic Quantum Dots for Cell Separation and Characterization. Patents J.O. Winter, K. Mahajan, G. Ruan, A. Duong, B. Wyslouzil “Methods for Producing Nanoparticles and Using Same,” U.S. Patent No. 9,550,160, filed September 27, 2012, issued January 24, 2017. (Additional claims still pending.)
DAVID W. WOOD Professor, Ph.D. Rensselaer Biotechnology, bioseparations, engineering.
Polytechnic biosensors,
Institute. protein
Refereed Papers Tran, K., Gurramkonda, C., Cooper, M. A., Pilli, M., Taris, J. E., Selock, N., Han, T-C., Tolosa, M., Zuber, A., PeñalberJohnstone, C., Dinkins, C., Pezeshk, N., Kostov, Y., Frey, D. D., Tolosa, L., Wood, D. W., and Rao, G., “Cell-free production of a therapeutic protein: Expression, purification, and characterization of recombinant streptokinase using a CHO lysate,” Biotechnology and Bioengineering, Vol. 115 (1), pp. 92-102 (2018).
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Lahiry, A., Fan, Y., Stimple, S. E., Raith, M. and Wood, D. W., “Inteins as tools for tagless and traceless protein purification,” Journal of Chemical Technology and Biotechnology, Published Online, doi:10.1002/jctb.5415 (2017). Cooper, M. A.,* Taris, J. E.,* Shi, C. and Wood, D. W., “A convenient self-cleaving affinity tag method for the purification of tagless target proteins (Invited Methods Paper),” Current Protocols in Protein Science, in press (2017).
Refereed Papers Andrew J. Amaya, Harshad Pathak, Viraj P. Modak, Hartawan Laksmono, N. Duane Loh, Jonas A. Sellberg , Raymond G. Sierra, Trevor A. McQueen, Matt J. Hayes, Garth J. Williams, Patents Marc Messerschmidt, Sébastien Boutet, Michael J. Bogan, US Patent #9,796,967 B2: Nellis, D., Wood, D. W., Zhu, J. Anders Nilsson, Claudiu A. Stan , and Barbara E. Wyslouzil, & Ma, B., “Reversible Regulation Of Intein Activity Through “How Cubic Can Ice Be?,” Journal of Physical Chemistry Engineered New Zinc Binding Domain,” Date of Patent: Oct. Letters, 8, 3216 – 3222 http://dx.doi.org/10.1021/acs. 24, 2017. jpclett.7b01142 (2017). biopharmaceutical on demand within 16 hours. Wood Lab is working on first-capture methods for the newly synthesized proteins using self-cleaving affinity tag technology.
Salehi, A. S. M., Shakalli Tang, M. J., Smith, M. T., Hunt, J. M., Law, R. A., Wood, D. W. and Bundy, B. C., “Cell-Free Protein Synthesis Approach to Biosensing hTRβ-Specific Endocrine Disruptors,” ACS Analytical Chemistry, Vol. 89 (6), pp. 33953401 (2017).
G.M. Nabar; K.D. Mahajan, M. Calhoun, A.D. Duong, M. Souva; J. Xu, C. Czeisler, V. Puduvalli, J.J. Otero, B.E. Wyslouzil, J.O Winter, International Journal of Nanomedicine, in press (2017). Viraj P. Modak, Harshad Pathak, Andrew J Amaya, Barbara E. Wyslouzil,”Freezing of supercooled n-decane nanodroplets: From surface driven to frustrated crystallization,” Phys. Chem. Chem. Phys., 19, 30181-30194, http://dx.doi.org/10.1.039/C7CP05431A (2017).
Lahiry, A., Stimple, S. D., Wood, D. W., Lease, R., “Retargeting a dual-acting sRNA for multiple mRNA transcript regulation,” ACS Synthetic Biology, Vol. 6 (4), pp. 648-658 (2017). Coolbaugh, M. J., Shakalli Tang, M. J., Wood, D. W., “Highthroughput purification of recombinant proteins using selfcleaving intein tags,” Analytical Biochemistry, Vol. 516, pp. 65-74 (2017). Grant Support $50,000 (2017-2018). PI David Wood, OSU Center for Applied Plant Science, CAPS Seed Grant: Design and Production of a Catalytic BChE Enzyme to Treat Organophosphate Poisoning. $90,679 (2017-2018). PI David Wood, EMD Millipore Corporation: Optimization of a self-cleaving tag system. $240,239 (2013-2017). PI David Wood, National Science Foundation (CBET) Chemical and Biological Separations: Highly controllable self-cleaving tags for biopharmaceutical research and manufacturing purification platforms. $1,013,472 out of $16M (2013-2017). PI Govind Rao, UMBC, subcontractor David Wood; DARPA: BioMod Program to develop a laptop-sized device that can produce any
BARBARA WYSLOUZIL Professor, Ph.D. California Institute of Technology. Aerosol science, nucleation, nanoparticle growth and structure, biomedical applications of aerosols. Awards and Honors Interviewed on Science Friday. Books and Book Chapters Gauri Nabar, Matthew Souva, Kil Ho Lee, Souvik De, Jodie Lutkenhaus, Barbara Wyslouzil, and Jessica O. Winter ,“Scalable Nanomanufacturing of Nanocomposites Using Spray-Based Approaches,” in Nanotechnology Commercialization: Manufacturing Process and Products, Thomas Mensah, Editor in Chief, Ben Wang, Brian Korgel, Virginia Davis, Jessica Winter, Editors, Wiley Inc, New York, American Institute of Chemical Engineering (2018).
Matthew S. Souva, Gauri M. Nabar, Jessica O. Winter, Barbara E. Wyslouzil, “Morphology of block copolymer micelles formed via electrospray enabled interfacial instability,” Journal of colloid and interface science, 512, 411-418 (2017). Grant Support $1,174,000 (2013-17). PI Jessica Winter, Co-PIs, Barbara E. Wyslouzil, Lisa M. Hall, Carol Lynn Alpert; National Science Foundation: SNM: Continuous, large-scale nanocomposite production via micellular electrospray. $475,000 (2015-18). PI Barbara E. Wyslouzil; National Science Foundation: Integrated studies of freezing. $355,000 (2015-18). PI Barbara E. Wyslouzil; National Science Foundation: Heterogeneous nucleation on nanoparticles. Patents Jessica O Winter, Gang Ruan, Barbara Wyslouzil, Anthony
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David Duong, Kalpesh Mahajan, “Methods for producing nanoparticles and using same,” U.S. Patent 9550160 B2. January, 2017.
C Cheng, Y Zhou, M Lin, P Wei, ST Yang, “Polymalic acid fermentation by Aureobasidium pullulans for malic acid production from soybean hull and soy molasses: Fermentation kinetics and economic analysis,” Bioresour. Technol., 223: 166–174 (2017).
H Fu, ST Yang, M Wang, J Wang, and IC Tang, “Butyric acid production from lignocellulosic biomass hydrolysates by engineered Clostridium tyrobutyricum overexpressing xylose catabolism genes for glucose and xylose coutilization,” Bioresour. Technol., 234, 389–396 (2017).
P Wei, C Cheng, M Lin, Y Zhou, ST Yang, “Production of poly(malic acid) from sugarcane juice in fermentation by Aureobasidium pullulans: Kinetics and process economics,” Bioresour. Technol., 224: 581–589 (2017).
M Shao, Z Sha, X Zhang, Z Rao, M Xu, T Yang, Z Xu, S-T Yang, “Efficient androst-1,4-diene-3,17-dione production by coexpressing 3-ketosteroid-Δ1-dehydrogenase and catalase in Bacillus subtilis,” J. Appl. Microbiol., 122(1), 119– 128 (2017).
J Feng, J Yang, X Li, M Guo, B Wang, ST Yang, X Zou, “Reconstruction of a genome-scale metabolic model and in silico analysis of the polymalic acid producer Aureobasidium pullulans CCTCC M2012223,” Gene, 607, 1–8 (2017).
S.T. YANG Professor, Ph.D. Purdue University. Bioprocess, biochemical, metabolic and tissue engineering; biofuels and bio-based chemicals; high throughput screening for drug discovery and bioprocess optimization; stem cell engineering. Books and Book Chapters S.T. Yang, K. Zhang, B. Zhang and H. Huang, “Fumaric Acid,” In Reference Module in Life Sciences, Elsevier, ISBN: 978-012-809633-8, http://dx.doi.org/10.1016/B978-0-12-8096338.09141-X (2017). Refereed Papers M Liu, Y Li, S-T Yang, “Effects of naringin on the proliferation and osteogenic differentiation of human amniotic fluid derived stem cells,” J. Tissue Eng. Regenerative Medicine, 11:276–284 (2017). M Shao, Y Chen, X Zhang, Z Rao, M Xu, T Yang, H Li, Z Xu, S-T Yang, ”Enhanced intracellular production of 3-ketosteroidΔ1-dehydrogenase from Mycobacterium neoaurum in Escherichia coli and its application in the androst-1,4-diene3,17-dione production,” J. Chem. Technol. Biotechnol., 92, 350–357 (2017).
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H Fu, X Wang, Y Sun, L Yan, J Shen, J Wang, ST Yang, Z Xiu, “Effects of salting-out and salting-out extraction on the separation of butyric acid,” Sep. Purif. Technol., 180, 44–50 (2017). Y Wang, X Song, X Li, ST Yang, X Zou, “Complete genome sequencing of polymalic acid-producing strain Aureobasidium pullulans CCTCC M2012223.” Acta Microbiol Sinica, 57(1), 97–108. (Chinese) (DOI: 10.13343/j. cnki.wsxb.2160197) (2017). C Xue, M Liu, X-W Guo, E P Hudson, L-J Chen, F-W Bai, ST Yang, C-S Song, “Bridging the chemical- and bio-catalysis: high-valued liquid transportation fuels production from renewable agricultural residues,” Green Chem., 19, 660– 669 [IF: 8.506] (2017). J Zhang, L Yu, M Lin, Q Yan, ST Yang, “n-Butanol production from sucrose and sugarcane juice by engineered Clostridium tyrobutyricum overexpressing sucrose catabolism genes and adhE2,” Bioresour. Technol., 233, 51–57 (2017). H Fu, L Yu, M Lin, J Wang, Z Xiu, ST Yang, “Metabolic engineering of Clostridium tyrobutyricum for enhanced butyric acid production from glucose and xylose,” Metab. Eng., 40, 50–58 [IF: 8.201] (2017).
Q He, Z Yang, B Gong, J Wang, K Xiao, ST Yang, “Quality evaluation focusing on tissue fractal dimension and chemical changes for frozen tilapia with treatment by tangerine peel extracts,” Sci. Reports, Feb 7; 7, 42202 (2017). C Xue, J Zhao, L Chen, ST Yang, F Bai, “Recent advances and state-of-the-art strategies in strain and process engineering for biobutanol production by Clostridium acetobutylicum,” Biotechnol. Adv., 35(2), 310–322 [IF: 11.8] (2017). Z Rao, Y Qi, T Yang, J Zhou, J Zheng, M Xu, X Zhang, S-T Yang, “Development of a multi-enzymatic desymmetrization and its application for the biosynthesis of L-norvaline from DL-norvaline,” Process Biochem., 55, 104–109 (2017). J Zhang, L Yu, M Xu, ST Yang, Q Yan, IC Tang, “Metabolic engineering of Clostridium tyrobutyricum for n-butanol production from sugarcane juice,” Appl. Microbiol. Biotechnol., 101, 4327–4337 (2017). Qurat-ul-Ain Ahmad, ST Yang, M Manzoor, JI Qazi, “Moderate alkali-thermophilic ethanologenesis by locally isolated Bacillus licheniformis from Pakistan employing sugarcane bagasse: a comparative aspect of aseptic and non-aseptic fermentations,” Biotechnol. Biofuels, 10:105 (2017).
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J Zheng, T Yang, J Zhou, M Xu, X Zhang, Z Rao, ST Yang, “Efficient production of D-amino acid oxidase in Escherichia coli by a trade-off between its expression and biomass using N-terminal modification,” Bioresour. Technol., 243:716–723 (2017).
D Wischral, H Fu, FL Pellegrini Pessoa, N Pereira Jr., ST Yang, “Effective and simple recovery of 1,3-propanediol from a fermented medium by liquid-liquid extraction system with ethanol and K3PO4,” Chin. J. Chem. Eng., in press (2017).
C Lu, L Yu, S Varghese, M Yu, ST Yang, “Enhanced robustness in acetone-butanol-ethanol fermentation with engineered Clostridium beijerinckii overexpressing adhE2 and ctfAB,” Bioresour. Technol., 243: 1000–1008 (2017).
A Abdella, AF El-Baz, IA Ibrahim, EE Mahrous, ST Yang, “Biotransformation of soy flour isoflavones by Aspergillus niger NRRL 3122 β-glucosidase enzyme, Natural Product Research,” published on line, DOI: 10.1080/14786419.2017.1413569 (2017).
T Yang, Z Rao, X Zhang, M Xu, Z Xu, ST Yang, “Metabolic engineering strategies for acetoin and 2,3-butanediol production: Advances and prospects,” Critical Rev. Biotechnol. (IBTY), 37(8): 990–1005 (2017). J Ou, N Xu, P Ernst, C Ma, M Bush, KY Goh, J Zhao, L Zhou, ST Yang, XM Liu, “Process engineering of cellulosic n-butanol production from corn-based biomass using Clostridium cellulovorans,” Process Biochem., 62: 144–150 (2017). M Xu, J Zhao, L Yu, ST Yang, “Comparative genomic analysis of Clostridium acetobutylicum for understanding the mutations contributing to enhanced butanol tolerance and production,” J. Biotechnol., 263: 36–44 (2017).
Grant Support $321,313 (2018-2021). National Science Foundation-CBET: Metabolic engineering of Aureobasidium pullulans for poly(L-malic acid) biosynthesis.
JACQUES ZAKIN (deceased) Helen C. Kurtz Professor Emeritus, D.Eng. Sci., New York University. Surfactant drag reduction, heat transfer enhancement, rheology.
$318,973 (2018-2021). National Science Foundation-CBET: Production of butyrate, butanol, and butyl butyrate from lignocellulosic biomass.
Books and Book Chapters Zakin, J. L., Maxson, A. J., Saeki, T., & Sullivan, P. F., “Turbulent Drag-reduction Applications of Surfactant $1,232,148 (2015-2018). Department of Energy EERE-BTI: Solutions” in Wormlike Micelles: Systems, Characterization Engineering Clostridia for n-butanol production from and Applications, C. Dreiss, Y. Feng (Eds.), Royal Society of lignocellulosic biomass and CO2. Chemistry (pp. 353-378) (2017) Refereed Papers Maxson, A., Watson, L., Karandikar, P., & Zakin, J., ”Heat transfer enhancement in turbulent drag reducing surfactant solutions by agitated heat exchangers.” International Journal of Heat and Mass Transfer, 109, 1044-1051 (2017).
Q Wu, L Zhu, Q Xu, H Huang, L Jiang, ST Yang, “Tailoring the oxidative stress tolerance of Clostridium tyrobutyricum CCTCC W428 by introducing trehalose biosynthetic capability,” J Agric. Food Chem., 65 (40), 8892–8901 (2017).
Grant Support $20,000 (2014-2017). Dreyfus Senior Mentoring Grant. $110,000 (2016-2018). Petroleum Research Fund Grant. $12,100 (2017). Ohio State Emeritus Academy Grant.
S Trakarnpaiboon, N Srisuk, K Piyachomkwan, ST Yang, V Kitpreechavanich, “L-Lactic acid production from liquefied cassava starch by thermotolerant Rhizopus microsporus: Characterization and optimization,” Process Biochem., 63: 26–34 (2017).
We are saddened by the loss of Professor Jack Zakin, a pioneer in the area of drag reduction who passed away on January 16, 2018. Dr. Zakin was a beloved professor, compassionate mentor and friend. A remembrance of Professor Zakin will appear in the Fall 2018 Koffolt News.
HK Yang, Z Wang, M Lin, ST Yang, “Propionic acid production from soy molasses by Propionibacterium acidipropionici: Fermentation kinetics and economic analysis,” Bioresour. Technol., in press (2017). Jacques L. Zakin, 1927 - 2018
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GRADUATE PROGRAM NATIONAL and INTERNATIONAL AWARDS / HONORS
ENROLLMENT
OSU FELLOWSHIPS
79 Doctoral students, 31 MS students (Fall 2017).
• Brodkey Scholarship: • Discovery Scholars Program Fellowshp: Jonathan Hightower • Metro Fellowship: Nick Wood • Pelotonia Research Fellowships: Donald Belcher, Chia-Wen Chang • University Fellowship: Archit Datar, Kalyani Jangam, Elizabeth Jergens, Nicole Walters, Qiaochu Zhang • Women in Engineering Graduate Student Scholarship: Chi Chen.
American Institute of Chemical Engineering • 2017 Catalysis and Reaction Engineering Travel Award: Deeksha Jain (Advisor: Ozkan) • 2017 Separations Division Graduate Student Award: Dongzhu Wu (Advisor: Bakshi) • AIChE Board of Directors, Catalysis & Reaction Engineering Division, Graduate Student Director: Deeksha Jain (Advisor: Ozkan).
OHIO STATE UNIVERSITY AWARDS
National Science Foundation Graduate Research Fellowships 2017: Richard Hickey (Advisor: Palmer); Hannah Zierden (2015 alumna, Advisor: Wood). 2018: Michael Charles (Advisor: Bakshi); Blaise Kimmel (2017 alumnus, Advisor: Fan).
DEGREES AWARDED 18 PhDs: Bhavik Bakshi: Varsha Gopalakrishnan Jeffrey Chalmers: Kyoung-Joo Jenny Park Liang-Shih Fan: Cheng Chung, Dikai Xu Lisa Hall: Youngmi Seo Winston Ho: Zi Tong, Dongzhu Wu Umit Ozkan: Kuldeep Mamtani, Katja Meyer, Youngmi Seo Andre Palmer: Kristopher Richardson Shang-Tian Yang: Chi Cheng, Xin Xin Winston Ho: Xi Tong Jessica Winter: Gauri Nabar, Matthew Souva Barbara Wyslouzil: Andrew Amaya, Matthew Souva Jacques Zakin: Andrew Maxson. 17 MS Degrees: Bhavik Bakshi: Varsha Gopalakrishnan, Muzhapaer Motianlifu Nicholas Brunelli: Nitish Deshpande, Rutuja Joshi, Aamena Parulkar Jeffrey Chalmers: Tyler Hacker, Robert Gammon Pitman, Kyoung-Joo Jenny Park Liang-Shih Fan: Prateek Kumar, Yaswanth Pottimurthy, Mingyan Xu Umit Ozkan: Deeksha Jain Kurt Koelling: Varun Venoor Jessica Winter: Abhilasha Dehankar Barbara Wyslouzil: Kehinde Ogunronbi Shang-Tian Yang: Chi Cheng, Guk hee Youn.
• Biomedical Engineering Society / Biomedical Engineering Graduate Student Association Research Symposium / Engineering Healthcare Industry and Research Symposium First Prize: Kilho Lee. • CBE Graduate Research Symposium Best Poster Award: Kayane Dingilian. • Institute for Materials Research Conference Student Poster Award: Saurabh Ailawar, Mariah Whitaker; Three-minute Thesis Award: Matt Souva. • University Laboratory Safety Committee Excellence in Safety Award-Research Group: Ozkan Group (inaugural award).
Journal of Clean Technologies and Environmental Policy, 2017 Outstanding Paper Award Varsha Gopalakrishnan (Advisor: Bakshi).
North American Membrane Society (NAMS) • 2018 Elias Klein Founders’ Travel Supplement Award: Yang Han (Advisor: Ho) • 2018 Young Membrane Investigators Award: Dongzhu Wu (Advisor: Ho). 23rd United Nations Climate Negotiations Bonn, Germany, Representative: Michael Charles (Advisor: Bakshi). 2018 North American Membrane Society • 2018 Young Membrane Scientist Award: Dongzhu Wu (Advisor: Ho) • 2018 Elias Klein Founders’ Travel Supplement Award: Yang Han (Advisor: Ho). Journal of Chemical Physics, cover feature Janani Sampath (Advisor: Hall).
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For more information, please visit go.osu.edu/2017CBEAnnRpt
SEMINAR SPEAKERS
2017 GRADUATE RESEARCH SYMPOSIUM
Anna Balazs University of Pittsburgh Aditya Bhan University of Minnesota Richard Grenville Philadelphia Mixing Solutions Graduate Research Initiative Program: Abhilasha Dehankar, Frank Kong Charles Haynes The University of British Columbia Belinda Hurley Ohio State University Libraries Shaoyi Jiang University of Washington Eric W. Kaler University of Minnesota Alexander Katz University of California-Berkeley Julie Kornfield California Institute of Technology Sonia Kreidenweis Colorado State University Ramanan Krishnamoorti University of Houston Mehmet Orman Memorial Sloan Kettering Cancer Center Christina Payne University of Kentucky Marjan Rafat Stanford University Eduardo Reátegui Massachusetts General Hospital, Harvard University Jindal Shah Oklahoma State University Samanvaya Srivastava The University of Chicago Levi Thompson University of Michigan Richard Vaia Air Force Research Laboratory Materials and Manfacturing, Wright Patterson Air Force Base Venkat Venkatasubramanian Columbia University Tim Watson OSU Graduation Services Huimin Zhao University of Illinois at UrbanaChampaign Andrew Zydney Pennsylvania State University.
Dr. Mahesh Kumthekar, Vice President of Veritive Corporation, provided the keynote address for the 2017 Graduate Research Symposium, attended by 20 industry representatives. Dr. Kumthekar gave graduate students career-building advice, including how to maximize networking efforts. “Networking is more than collecting business cards -- it’s about building relationships and offering to help others without expecting anything in return,” he said. Another suggestion he made was to try new things and explore areas outside one’s comfort zone in order to grow stronger and identify potential new areas of interest. As the vice president for Veritiv Corporation, a $8.5B Fortune 500 company based in Atlanta, Dr. Kumthekar oversees the Program Management Office that drives enterprise-wide projects in operations, procurenement, sales and supply chain across all business units and regions for Veritiv. He completed his M.S. (‘92) / Ph.D. (‘96) from The Ohio State University in heterogeneous catalysis focusing on NOx reduction in Professor Umit Ozkan’s group and published 10+ peer-reviewed articles in top journals including Journal of Catalysis and Applied Catalysis. He also completed his MBA from University of Michigan’s Ross Business School in 2003. “I truly enjoyed learning about the cutting-edge research at the Symposium,” Dr. Kumthekar said after the event. “I was very impressed with the quality of work and dedication displayed in both the oral presentations as well as the poster sessions. The event certainly exceeded my expectations.” To learn more about GRS or to get involved, please email grs@osu.edu. __ The Graduate Research Symposium (GRS) is an annual event organized by graduate students in the William G. Lowrie Department of Chemical and Biomolecular Engineering. Sponsored by Dow Chemical Company, the event includes industry participants such as Exxon Mobil, Shell, Eli Lilly, Procter & Gamble, and Owens Corning. It has become a prominent platform for graduate students and faculty to network with industry representatives, resulting in opportunities for students to obtain internships and full-time positions. 2017 GRS Committee: Aamena Parulkar and Abhilasha Dehankar (co-chairs and external publicity), Mariah Whitaker and Rutuja Joshi (website), Nitish Deshpande (external publicity), Deeksha Jain, Dhruba Jyoti Deka, Tapajyoti Ghosh (scheduling), and Deeksha Jain, Jenny Park and Rutuja Joshi (presentation coordination). Deven Baser and Saurabh Ailawar also participated.
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UNDERGRADUATE PROGRAM 2017 ENROLLMENT 1,038 students (Fall 2017)
2017 DEGREES AWARDED 236 Bachelor of Science degrees
NATIONAL STUDENT AWARDS
National Science Foundation Graduate Research Fellowship Honorable Mentions 2017 Kevin Ikeda (Advisor: Fan) Lagnajit Pattanaik (Advisor: Brunelli) 2018 Vasiliki Kolliopoulis (Advisor: Castro); Jacob Paul Martin and Hopen Kaichi Yang (both ‘17 alumni, Advisor: Wood).
LOCAL STUDENT AWARDS
Denman Undergraduate Research Forum 2017 Charles Fryer (1st place, Fan) Lagnajit Pattanaik (1st place, Brunelli) Blaise Kimmel (2nd place, Fan) Monica Chan (3rd place, Weavers) Sushmitha Ravikumar (3rd place, Ozkan) 2018 Ivan Pires (1st place, Palmer) Lucas Watson (1st place, Zakin) Emma Garber (3rd place, Fan). Emma also won the Sustainability Competition in Climate Change. Engineering Undergrad Research Forum 2017 First Place (two awarded) Kate Clelland (Advisor: Fan) Ivan Pires (Advisor: Palmer) 2018 Second Place Benjamin Rudzinski (Advisor: Ozkan). Ohio State University Board of Trustees Student Recognition Award Ivan Pires (Advisor: Palmer). 2017 Pelotonia Research Fellowship Ivan Pires (Advisor: Palmer). - 36 -
COOPERATIVE LEARNING
• 98 co-op rotations • 106 internship or part-time work experiences Companies hiring three or more students: Abbott, Anomatic Corp., Anheuser-Busch, Battelle Memorial Institute, Cargill, Chemical Abstracts Service, Cooper Tire & Rubber, DowDuPont, ExxonMobil, Glatfelter, Goodyear Tire & Rubber Co., J.M. Smucker Co., L’Oreal USA, Lubrizol, LyondellBasell, Marathon Petroleum Corp., Nestle, Owens Corning, pH Matter LLC, Procter & Gamble, Scotts MiracleGro, and Sherwin-Williams.
PLACEMENT RECORD*
• 64% of students who completed a survey at the time of graduation reported employment • 50% entered industry • 12% are pursuing graduate degrees (33% of these are remaining in Ohio) • Average starting salary: $67,853 Major Employers for 2017: Cargill, Dow Chemical, Epic, ExxonMobil, General Mills, Kraft Heinz, Nestle, Owens Corning, Procter & Gamble, and PolyOne.
For more information on Cooperative Learning and Placements, please visit go.osu.edu/2017CBEAnnRpt
*For a complete list of students and employers, please visit go.osu.edu/2017CBEAnnRpt
Engineering Career Services (ECS) welcomes employers to register and recruit Ohio State engineering students and graduates for internships, co-ops, and full-time employment for no fee. Please visit ecs.osu.edu
JAMES AND PATRICIA DIETZ UNIT OPERATIONS LABORATORY 313 students completed Unit Ops in 2017.
William G. Lowrie Department of Chemical and Biomolecular Engineering Enrollment Summary in Percentages* Combined (Majors and Premajors) Students Women Ethnic Minority Premajors (Students who have not taken CBE 2200) Students Women Ethnic Minority Majors (Students completed or enrolled in CBE 2200) Students Women Ethnic Minority
2013
2014
2015
2016
2017
804 29.10% 9.80%
930 29.03% 9.03%
949 30.20% 7.60%
1000 1038 32.70% 33.50% 6.70% 6.90%
269 31.50% 10.40%
295 31.50% 9.80%
279 29.30% 7.50%
306 308 31.30% 32.14% 8.50% 10.06%
535 27.80% 9.50%
635 28.30% 8.66%
670 30.50% 7.70%
694 730 32.70% 34.10% 6.70% 5.60%
*Data taken in January. Background photo by Eric Collins, 2016
LAB EXPERIENCE LEADS UNDERGRAD TO PERFECT REACTION Anyone who has taught or mentored chemical engineering students knows that they are a rare breed. Driven by curiosity, competitiveness, analytical proficiencies and keen time management, they often achieve great things.
The successes have been something of a surprise for Charlie, who started in chemistry major but switched to chemical engineering in order to focus more on math, one of his key skills.
Even so, it isn’t every undergrad who not only publishes their research, but files a patent.
To bolster his classroom learning, he applied for a research assistant position with Dr. Fan, whom he knew was impactful worldwide. Initially, he did simulations on the gas > liquid chemicals process, working with Abbey Empfield (Class of ‘16), an inaugural recipient of one of the Edward Claugus (‘81; deceased) scholarships created in 2015.
Meet Charlie Fryer. Charlie, who graduated in December 2017, has done both. In recognition of this achievement, the department created a new award to honor him - the William G. Lowrie Department of Chemical and Biomolecular Engineering’s Undergraduate Patents / Publishing Award. The pending patent, “Chemical Looping Syngas Production from Carbonaceous Fuels,” is for a modular chemical looping process that can utilize a CO2 feedstock as a partial substitute for natural gas and leverage the corresponding syngas production nonlinearities to minimize the overall natural gas consumption. Compared to a conventional full-scale gas-to- liquid plant, this process can significantly reduce natural gas consumption, while operating under CO2 neutral conditions. Charlie is also a co-author on three scientific journal articles. The first article, published in Energy & Environmental Science, was featured on the journal’s cover and has been cited 10 times as of November, 2017. A second article appeared in the AICHE Journal and has four citations. A third article in Energy & Fuel was published in January 2018. Charlie is also listed as a co-author of Professor L.-S. Fan’s new book, “Chemical Looping Particle Oxidation: Gasification, Reforming, and Chemical Synthesis,” published by Cambridge University Press.
Charlie was collecting data in Aspen, running tests and analyzing them, when he realized that he could improve the chemical looping system efficiency by leveraging non-linear thermodynamic trends associated with syngas generation. When this modularization strategy- based chemical looping system is used to replace conventional gas to liquids syngas generation units, simulations show that for the same amount of liquid fuel production, natural gas consumption can be reduced up to 25%. “I never thought that anything like this would happen to me,” Charlie confessed. “I’m so grateful for the resources here, and for my mentors, who have been very generous with including me in the credits.” “Dr. Fan is absolutely amazing, and post-doctoral researcher Dr. Mandar Kathe has been a key element of my entire research career at Ohio State. He’s been absolutely instrumental in all of my accomplishments,” Charlie said.
Charles Fryer, ‘17
Making a discovery with the potential for significant impact was hard for Charlie to take in at first. “It was really exciting. I couldn’t stop thinking about the implications of what I was working on!” Charlie said. “I love nature and the environment, so working in clean energy is very important to me,” he added. Charlie began working at Exxon after graduating, serving as part of a consulting team to process engineers around the world. “We’ll do equationoriented modeling to determine possible solutions for them,” he explained. “I’m excited to get to work and begin to apply everything I’ve learned, and all my experiences to date, in this new situation.” He credits personal networking with helping him to find the job. He talked to department alumni at the Graduate Research Symposium and saw some of them later at the College of Engineering Career Fair. They encouraged him to apply, and happily, he got the job.
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ALUMNI NEWS 2017 E.V. Murphree Award in Industrial and Engineering Chemistry, American Chemical Society
2017 John B. Gerlach, Sr. Development Volunteer Award, The Ohio State University
LINDA J. BROADBELT, ‘89
WILLIAM G. LOWRIE, ‘66
Associate Dean for Research, McCormick School of Engineering and Applied Science; Sarah Rebecca Roland Professor, Department of Chemical Engineering, Northwestern University
Retired Deputy CEO, Amoco Corporation
2017 National Science Foundation CAREER Award
2018 Dean’s Meritorious Services to Students, The Ohio State University College of Engineering
JACOB ELMER, ‘11 Assistant Professor of Chemical Engineering Villanova University (story on facing page)
KAREN T. MURPHY, ‘79 Principal Industry Specialist, Chemical Sector, International Finance Corporation (retired)
2017 Innovation Award - Most Disclosures Filed; OSU Institute of Materials Research; 2017 Lumley Interdisciplinary Research Award, Ohio State University College of Engineering
2017 Texnikoi Outstanding Alumni Award, The Ohio State University College of Engineering
DANIEL GALLEGO-PEREZ, ‘11
Shanahan Family Faculty Scholar 2017-18, Assistant Professor of Organizational Behavior, Stanford University
ADINA D. STERLING, ‘02
Assistant Professor The Ohio State University College of Medicine
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2017 Distinguished Alumni Award, The Ohio State University College of Engineering
2017 National Science Foundation Graduate Research Fellowship
WILLIAM C. LEIPOLD, ‘72
HANNAH C. ZIERDEN, ‘15
President and CEO Columbine Plastics Corporation
PhD candidate in chemical engineering and NSF Fellow; Center for Nanomedicine, Johns Hopkins University
JACOB ELMER EARNS NSF CAREER AWARD FOR GENE THERAPY RESEARCH It’s been a great year for Jacob Elmer (Ph.D. ‘11), assistant professor of chemical engineering at Villanova University. Not only did he win a highly prestigious $500,000 National Science Foundation (NSF) CAREER award, he received $300,000 from the National Science Foundation to streamline the production of genetically-engineered T cells to treat leukemia patients and $254,000 from the National Institutes of Health to study earthworm hemoglobin as a potential blood substitute. This is the kind of success any young professor dreams about, and Dr. Elmer traces it back to one thing – a love of research. Becoming an academic was not his initial plan, but while studying biology and chemical engineering at Missouri University of Science and Technology in anticipation of a career in agriculture, a NASA internship working on bioregenerative life support systems changed his mind. “I have always enjoyed problem-solving,” he said, “but it was during my internship that I discovered a passion for research. I knew then that a Ph.D. was in my future.” When choosing a Ph.D. program, one university stood out. “The CBE department at The Ohio State University placed a stronger emphasis on cutting-edge biological research than other ChemE departments I considered,” Dr. Elmer said. “Also, being from the midwest myself, the campus and city of Columbus felt more like home than other larger cities,” he added.
At Ohio State, Elmer studied blood substitutes with Professor (now Chair) Andre Palmer. “Dr. Palmer helped me develop into an independent researcher, but that wasn’t all. At Ohio State, I was trained in all three aspects of a professor’s job: research, teaching, and service. I had the freedom to develop my own research projects; received training in the grant writing process; and was given the opportunity to develop and eventually teach my own course. I also participated in several outreach projects. Overall, it was an exceptionally well-rounded experience that prepared me for life in academia,” he said. As a postdoctoral researcher, he initially focused on gene therapy -- specifically, how to best insert genes into cells. The field was already crowded, though, so he decided to focus instead on getting the gene to survive once inside the cell, where cellular defenses work against it. That was the motivation for his first National Science Foundation grant, “Manipulating Epigenetic Mechanisms to Enhance Transgene Expression” (2014). His CAREER grant, “Manipulating the Innate Immune Response to Improve Gene Therapy,” is the second iteration of that research.
Professor Elmer works with a student in the laboratory.
Now, Professor Elmer is looking at the fate of the gene when it’s still in the cytoplasm, before it reaches the nucleus. By identifying which genes get turned on and finding out what they do, he’ll be able to use that knowledge to inhibit or enhance the way those genes react when a new, therapeutic gene is introduced to the cell. That’s the plan, anyway. As any researcher knows, things don’t always go as planned. On such days, Elmer takes a positive view. “I can always come back to teaching and have fun with it,” he said. -Based on a story by Kim Shimer, Villanova University.
Elmer with students from his research group.
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PHILANTHROPY SCHOLARSHIPS
DONOR-ESTABLISHED SCHOLARSHIPS
We thank the corporations and alumni for their vital support in establishing scholarships for CBE students.
• • • • • • • •
Scholarship funding for 2017 totaled $344,550 - an increase of $37,750 over the previous year. A total of 138 students received an average of $2,496 compared to $2,223 the year before. For a list of recipients, visit go.osu.edu/2017CBEAnnRpt.
• • • • • • • • • • • • • • •
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Robert W. Adams Memorial Scholarship Harold W. Almen Scholarship Paul Bates Scholarship The George S. Bonn Scholarship J.R. Boothe Scholarship Fund Robert S. Brodkey Scholarship William I. Burt Memorial Scholarship Class of 1969 Chemical Engineering Endowed Scholarship Fund Bernice L. Claugus Endowed Scholarship Fund Daniel and Ellen Coombs Chemical Engineering Endowed Scholarship James F. and Patricia C. Dietz Engineering Scholarships Fund Dorothy J. & Herbert L. Fenburr Scholarship David H. George Chemical Engineering Scholarship Allan I. Gordon Undergraduate Scholarship for Study in Biochemical Engineering Todd David Harris Memorial Scholarship William R. & Doris M. Harris Scholarship in Chemical Engineering Milton & Karen Hendricks Scholarship Smith E. Howland Scholarship Samuel S. and Grace Hook Johnston Memorial Chemical Engineering Scholarship Fund Webster B. Kay Scholarship Lubrizol Foundation Scholarship Tom and Gail Reardon Chemical Engineering Scholarship Fund Pankaj Shah Chemical Engineering Scholarship Fund
• The Howard R. Steele Memorial Scholarship in Chemical Engineering • Aldrich Syverson Scholarship • H. Richard Unkel Chemical Engineering Class of 1941 • Harry B. Warner Scholarship • William H. Whirl Scholarship • Michael D. Winfield Scholarship • Ronald and Susan Vlcek Chemical Engineering Scholarship • Fred H. Winterkamp Memorial Scholarship
CHAIRS
• Bernice L. Claugus Chair; Donor: Edward Claugus (‘81) • Helen C. Kurtz Chair • Ohio Eminent Scholar • Richard M. Morrow Chair
PROFESSORSHIPS
• H.C. “Slip” Slider Professorship; Donors: Ernestine and William G. Lowrie (‘66) • C. John Easton Professorship
2017 CHARITABLE DONATIONS FROM CBE ALUMNI BY CLASS YEAR 1944 1946 1948 1949 1951 1952 1953
Wallace L. Bostwick Edward A. Broestl (Deceased) David E. James, Henry B. Lange Robert E. Kraus Bruce E. Hill Donald E. Haupt, Charles J. Schmitz Walter E. Donham, Donald E. Findlay, Wilfred C. Ling 1955 John R. Blunden, Wendell B. Hammond 1956 John W. Cammarn, Robert A. Cody, Herbert H. Fanning, David A. Strang 1957 Walter R. Andrews, Jon D. Helms 1958 John J. Connelly, Barry C. Hartley, Werner S. Lichtenstein, James W. Stark 1959 James H. Laughlin 1960 Guy A. Crossley, Joseph O. Estill, Warren E. McAdams, Irwin Weinstock, Russell L. Wilt 1961 Paul R. Bigley, Richard B. Cooper, Jack A. Hammond, Ronald D. Harris, Gordon R. Howard, David A. Parker, L E. Woodworth (Deceased) , Martin F. Cohen, Kenneth J. Fulk, Dean Snider, Michael J. Sorocak, Michael D. Winfield 1963 John P. Henry, Robert P. Kasper, Kay L. Snider 1964 Alkis Constantinides, Michael B. Cutlip, James B. Sapp 1965 Edward R. Corino, Ronald S. Evanko, Frederick H. Flor, Eugene N. Wheeler 1966 James V. Braun, Thomas E. Fitz, Glenn L. McKee 1967 John S. Dorsey, C. D. Dunlap, Dennis W. Hurley, Graham F. Painter, Anthony Santavicca 1968 Richard T. Linak, David J. Walters, Gerald A. Wilcox (Deceased) 1969 John W. Toussant 1970 Bradford F. Dunn, Gary W. Good, David R. Grove, Harry H. Yieh (Deceased)
1971
1973 1974 1975 1977 1978 1979 1980 1981 1982 1983
1984 1985 1986 1987 1988 1989
Juliet A. Balmer, Karen L. Hendricks, Jeffrey L. Kosch, David O. Kutscher, William E. Pritchard, Harrison L. Stebbins, Richard D. Stolk, Paul R. Swartz, Charles L. Steel (Deceased) John C. Bost, Charles N. Carpenter, David A. Dargan, Dennis D. Terry George L. Ott John T. Erikson, Stephen L. Grant, James S. Watt Robert L. Collins Daniel M. Coombs, James H. Etherton, Rad V. Scott, David P. Steinmetz, Paul W. Vance Karen T. Murphy, Gary S. Phillips, Ronald D. Vlcek, Tad K. Williams Frederick T. Clark, Paul T. Dubetz, Carol B. Ehrman, Fred D. Ehrman, Matthew J. Galosi, Joseph Petrarca Nancy C. Dawes, William J. Dawson Douglas H. Baughman, Deborah M. Grzybowski, Daniel P. Lambert, Christina S. Sistrunk, Heng-Sheng J. Torng Rich H. Brandon, Stephen R. Cammarn, Linda S. Evans, Mark H. Gaston, Keith R. Nowak, Jeffrey W. Patterson, Christopher R. Richied, Anne E. Samanich, Clark B. Wade, Robert E. Young Yousef G. Aouad, Teresa L. Datz-Siegel, Sunil Satija, Leonore Witchey-Lakshmanan Douglas J. Ball, Andrew W. Bur, Rebecca K. Bur, Thomas D. Burns, Timothy A. Johnson, David J. Moonay Kris Lakshmanan, Andrew J. Sherman, Raymond M. Yurick Denise M. Burcham, Karen S. Johnson, Dallas B. Noe, Robert L. Tatterson John A. Bohlmann, Julia C. Boughton, John W. Oren, Paula F. Oren, Bhavesh V. Patel Linda Broadbelt
1990 1991 1992 1993 1994 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2017
Christopher Kiehl, James V. Lombardi, Scott A. Westfall Kristan K. Latham, Richard L. Wright Pamela J. Archer Yeping Cai, Mark R. Kinkelaar, Frank E. Seipel Darren L. Tanner, Christopher W. Voight Mahesh W. Kumthekar, Liping Zhang Sam S. Ang, John D. Clay Aravind R. Asthagiri, Gary O. Spitznogle, Michael T. Timko Enrique Aceves De Alba, James W. Holder David L. Breitenbecher, Zhiqing Lin Abdu Y. Bunch, Rick B. Watson Lisa A. Catauro, Jun Luo, Timothy M. Price, Yunying Qi Xiangmin Han, Siyi Lai Nicholas A. Brunelli, Lori A. Engelhardt, Erica N. Jones, Liyong Yu Sittichai Natesakhawat, Ah-Hyung Park, Garrett E. Pavlovicz, Ying Zhang Andrew D. Galusha, Anli Ouyang, Robert H. Walters Laura M. Ensign-Hodges, John N. Kuhn, Maxwell J. Wingert Jeffrey R. Skinn, Lingzhi Zhang Wu Ge, Cathryn J. Marshall, Carol U. Pritchett, Hua Song, Andrew W. Vail, Lindsay M. Volpenhein Elizabeth J. Biddinger, Nandita Lakshminarayanan Japheth A. Pritchett, Yipin Zhou Preshit V. Gawade, Michael M. Hamilton, Haifeng Shi, Dylan M. Silbiger Dameon M. Medley Deepika Singh Jacob A. Buszek, Clayton J. Deighan, Anshuman Fuller, Patrick M. Kehn, Feibi Yuan Deeksha Jain, Kuldeep B. Mamtani, Andrew Maxson, Katja E. Meyer. - 41 -
Donations from Other Ohio State Graduates Mamta B. Bakshi, 2003 Cheryl L. Ball, 1985 Angela S. Bennett, 2002 Nancy A. Cammarn, 1956 Sally C. Carpenter, 1960 Sharon L. Cavin, 1995 Julie A. Chalmers, 1992 Sharon R. Clark, 1980 Kristy S. Clay, 1996 Rochelle P. Cohen, 1962 Mary Ellen Coombs, 1979 Mark E. Dawes, 1981 Eugenia M. Etherton, 1985 Izabela Gierach, 2015 Wendy A. Good, 1967 Kathryn W. Grant, 1975 Vicki Grove, 1969 Jane A. Harris, 1960 Jeanne A. Howard, 1956 Barbara E. Hurley, 1970 Timothy R. Ingle, 2008 Karin J. Kinkelaar, 1989 Marianna Kraus, 1949 Yoshie Narui, 2003 Carolyn E. Patch, 1966 Lisa A. Price, 2003 Robin S. Scott, 1978 Sally H. Sorocak, 1961 Patricia J. Stolk, 1970 Kathleen G. Tatterson, 1987 David W. Thomson, 1964 Thomas J. Tibbitts, 1955 Libby W. Toussant, 1969 Patrick J. Tracy, 1971 C. S. Vlcek, 1980 Jill C. Wade, 1984 Stacy Weislogel, 1962 Barbara B. Weiss, 1970 John P. Weiss, 1983 Shu-Huan Weng, 1979 Marlene H. Wilcox, 1958 Chihae Yang, 1981 Molly C. Yieh, 1971 David F. Zakin, 1982 Friends of CBE Saurabh A. Ailawar Eunice G. Andrews Bhavik R. Bakshi Charles F. Balmer Janet W. Baughman Joshua A. Biddinger
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Lavada M. Bigley (Deceased) Donna Bohlmann Mike Bolger Rosa Bolger Dorra L. Bost Betty J. Bostwick William F. Boughton Beth E. Brandon Carolyn C. Braun Kimberly A. Breitenbecher Kevin Brewer Mary Brewer Robert S. Brodkey Rita E. Broestl Jonathan R. Brown Michael W. Burcham Lynn R. Burns Greg T. Busch Ping Cai Tavane C. Cammarn Michael Catauro Gokhan Celik Jeffrey J. Chalmers Szu-Chia Chien Lois W. Cody Virginia A. Connelly Marilyn Cooper Stuart L. Cooper Marlene D. Corino LaDonna F. Crossley Darren Crystal Michelle Crystal Timothy W. Cuff Susan F. Cutlip Sharon K. Dargan Jim Davis Diane S. Dawson Dhruba J. Deka Aziza Doleh Dawn M. Doleh Mohamad Doleh Yaser K. Doleh Trudy Donham (Deceased) Carmel P. Dorsey Victoria B. Dubetz Alberta E. Dunlap Hope E. Erikson Diana K. Estill Bonnie S. Evanko Leigh H. Evrard Sharon R. Evrard Liang-Shih Fan Gail L. Feinberg Martin R. Feinberg
Marilyn J. Findlay June W. Fitz Lynn D. Flanagan Marlene G. Flor Helen M. Fulk Susan S. Galosi Carl M. Good Seval Gunduz Lisa M. Hall Tracy B. Hamilton Joy P. Hammond (Deceased) Mary Z. Hammond Mary Lou S. Hartley Mildred B. Haupt (Deceased) Sharon A. Helms Milton H. Hendricks (Deceased) Harry C. Hershey Annie Ho W.S. W. Ho Lee A. Holder April P. Ingle Carol E. Ingle Richard J. Ingle Ellen H. James Audrey M. Johnson Taeko Kawaguchi Yasuo Kawaguchi Layha Khoo Christopher S. Kochanek Heather Koelling Kurt W. Koelling Linda J. Kosch Elizabeth Kuhn James H. Kulp Paulette K. Kulp Kay Kumthekar Chizue Kusaka Isamu Kusaka Nancy L. Kutscher Nancy K. Lambert Alejandro Landaverde Missy R. Landaverde James L. Latham Sandra M. Laughlin Sandybeck Lease L. J. Lee Gong Liang Li Li-Chiang Lin Sharon P. Linak (Deceased) Celia C. Ling Chang Liu Marie C. Lombardi Joseph M. Lopatka Rachele C. Lopatka
Mark V. Lorson Ernestine R. Lowrie Wilhelmina H. McAdams David McGee Elizabeth M. McKee Kendra Medley Aaron Moment James Montague Michele Montague Holly Nicholas Michele L. Noe Kaye Norenberg Scott D. Osborne Janet M. Ott Michael Owens Erdal Ozkan Umit S. Ozkan Andre F. Palmer Carol H. Parker Shital B. Patel Barbara Patterson Gary K. Patterson Margaret A. Patterson Kathleen J. Petrarca Janell S. Pritchard James F. Rathman Katelyn E. Reilly Matthew A. Reilly James E. Rekoske Virginia Richied David E. Samanich Debra D. Santavicca Linda S. Sapp Carlo Scaccia Kathleen A. Schmidt Lilly A. Seipel Wilbur M. Seipel (Deceased) Tina Shafer Minerva Sherman Randall A. Siegel Carolyn Simonoff John B. Sistrunk Sarah Slauson Maria Sotos Lynette D. Spitznogle Patricia A. Stark (Deceased) Susan Stebbins Harry Steindler Marcy Steindler Margaret R. Strang (Deceased) Guoyong Sun Laurie Y. Swartz Beverly M. Sweeney Thomas L. Sweeney
Lynda Talmon Yeshayhu Talmon I-Ching Tang Xiaming Tang Carol A. Terry Susan A. Tesfai Millicent B. Thomson Barbara J. Tibbitts Amy J. Tomasko David L. Tomasko Rene A. Vance Rebecca H. Voight Yolan J. Walters Xueqin J. Wang Bonnie M. Watt Elisabeth L. Westfall Cindra Wheeler Mary E. Wilcox Michael Wilcox Susan C. Williams Wenda Williamson Cynthia E. Wilt Arlene S. Winfield Jessica O. Winter David W. Wood JoAnn Woodworth Barbara E. Wyslouzil Kamin Xu Shang-Tian Yang Debra F. Young Barbara Zakin Richard J. Zakin YanYan Zhang Ling Zhang-Watson Yanfen Zhu Corporations/ Organizations Acquia Inc. Albemarle Foundation Benevity Community Impact Fund for The Clorox Company BP BP Foundation Inc. Bristol-Myers Squibb Foundation Capital Resin Corporation Cascade Natural Gas Corporation Charities Aid Foundation America Dow Chemical Company Foundation Chevron Corporation Chipotle Mexican Grill Inc. Richard B. Cooper Fund of The Schwab Charitable Fund
Corning Incorporated Foundation Dow Chemical Foundation Dow Corning Corporation Eli Lilly & Company Elizabeth McKee Living Trust Exxon Mobil Corporation ExxonMobil Foundation Green Biologics Inc. Higher Education Commission IBM International Foundation Johnson & Johnson Lease Family Philanthropic Fund of the Jewish Federation of Greater Atlanta William and Ernestine Lowrie Family Fund of Fidelity Charitable Lubrizol Foundation LyondellBasell Industries Marathon Petroleum Company LP MDU Resources Foundation Network for Good Network for Good - Abbott Fund Occidental Petroleum Corporation Ohio Power Company Owens Corning P&G Fund of The Greater Cincinnati Foundation PepsiCo Foundation Pfizer Foundation Sealed Air Corporation Shakti of the Ayco Charitable Foundation Shell Oil Company Shell Oil Company Foundation Sherwin-Williams Foundation Tesoro Foundation Inc. Tesoro Petroleum Corporation Michael & Arlene Winfield Family Fund of the Chicago Community Foundation
FACULTY / STAFF Professors Bhavik Bakshi Jeffrey Chalmers Stuart Cooper Liang-Shih Fan W.S. Winston Ho Kurt Koelling L. James Lee Umit Ozkan Andre Palmer James Rathman David Tomasko Jessica Winter David Wood Barbara Wyslouzil Shang-Tian Yang Associate Professors Aravind Asthagiri Isamu Kusaka Assistant Professors Nicholas Brunelli Lisa Hall Li-Chiang Lin Eduardo Reรกtegui Katelyn Swindle-Reilly Clinical Faculty John Clay Ilham El Monier Deborah Grzybowski Andrew Maxson Emeritus Professors Robert S. Brodkey Martin Feinberg Edwin Haering Harry C. Hershey Michael Paulaitis Thomas L. Sweeney
Research Assistant Professor Andrew Tong Adjunct Professor Gang Ruan Research Scientists Jonathan Brown Dawei Wang Research Associates Pengfei He Kwang Kwak (Sr. Associate) William Kane Wang Lang Qin Post Doctoral Researchers Feng Chen Zhuo Cheng Doruk Dogu Seval Gunduz Pengfei He Jiaming Hu Mandar Kathe Veysi Malkoc Lang Qin Yan Sheng Mengmeng Xu Chi-Ta Yang Zhaogang Yang Aili Zhang Jingbo Zhao Yanan Zhao
Visiting Scholars Sydney Brannan Yuhuan Geng Qi He Weiming Li William Light Dan Lin Norman Loney Zhiyu Min Shilun Ruan Baowei Su Xiaobing Wang Yue Wang Duo Yang
Administrative Staff Angela Bennett, Graduate Program Coordinator Katie Bush-Glenn, Academic Advising David Cade, Building Coordinator Bill Cory, Human Resources Manager Brian Endres, Academic Advising Leigh Evrard, Design Engineer Lynn Flanagan, Grants Manager Sean Gallagher, Director of Development Daniel Kline, Editor for L.-S. Fan Scott Osborne, Business Manager Sean Gallagher, Director of Development Geoff Hulse, Director of Information Technology Susan Tesfai, Fiscal Associate Mike Wilson, Laboratory Supervisor Wenda Williamson, Editor/Public Relations Coordinator
Back cover image: Quantum dots synthesized in the Winter lab. Winter and her team are developing quantum dot semiconductor nanoparticles to enable visualization of proteins inside cells.
Hall Group fall outing to Curtis Orchard.
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WILLIAM G. LOWRIE DEPARTMENT OF CHEMICAL AND BIOMOLECULAR ENGINEERING 314 Koffolt Laboratories CBEC - 151 West Woodruff Avenue Columbus, OH 43210-1350 Phone: 614-292-4000 Fax: 614-292-3769 Web: cbe.osu.edu Facebook: go.osu.edu/CBEfacebook Twitter: go.osu.edu/CBEtwitter Linked In: go.osu.edu/CBElinkedin
Background image: Nature Communications, Figure 2 from Eduardo Reátegui’s “Engineered Nanointerfaces for Microfluidic Isolation and Molecular Profiling of Tumor-specific Extracellular Vesicles,” 9, (1), 175 .(2018).