Welcome

A Warm Welcome from Tony Jones

This yearly publication provides the opportunity for us to reflect on a year of One Nucleus activities, to highlight some of the successes and insights gained by our members and wider Life Sciences sector as they progress their businesses and take a look forward in terms of plans for the year ahead. In addition, it enables us to set out the characteristics of our network, the engagement opportunities available and some of the One Nucleus thinking around how we support our members going forward. And what a year it has been between March 2020 and writing this article. Greater details of some of the trends, deal highlights and thought leadership in key areas are set out in the articles that follow. In this section I would just like to offer you a warm welcome to the One Nucleus Annual Review and set the scene for the subsequent content.

Progress in unprecedented times

It would be impossible to reflect on the past year without considering the context of Covid-19, how the sector has been successful in responding to create diagnostics, vaccines, treatments to combat Covid-19 as well as generating an immense amount of scientific understanding of the SARS-CoV-2 virus. There is still a long way to go to fully understand the virus and indeed how to live with it, but it has undoubtedly been a year of unprecedented progress and collaboration at scale. From the strong academic base through to large multinational pharma; including the innovative SMEs; their professional advisers and investors, it is hard to see any segment of the One Nucleus membership that has not been actively involved in helping the world deal with the pandemic. It should not be forgotten that progress was not only against Covid-19. There have been many significant product development, investment and technological advance highlights in other therapeutic areas throughout the year. This breadth of success illustrating the resilience and adaptability of the Life Science institutes and companies to remain so active.

Sector Highlights

Globally, it has been reported that biotech raised $42 billion in 2020 across 1851 deals (A Khemlani), a massive 46% increase over 2019 in terms of money raised yet only a 4% increase in deal numbers. Closer to home, the UK Life Science sector also had a record year, raising £2.4Bn. The current year is on course to be an even greater value if the deal activity remains high. Clarivate/BIA notably reporting last month that £830 million having been raised in the three months to the end of February 2021 – almost as much as the first six months of 2020. Mergers and acquisitions have been stellar also. Business Weekly reporting that M&A deals in the previous year for the Cambridge region alone had topped £100 billion. The increased popularity of SPACs (special purpose acquisition vehicles) is seeing traditionally earlier stage investors be more involved companies going to IPO. Is this growth in interest driven by the spotlight now placed on the value the sector can bring to society and will investment levels scale down when interest rates start to rise, perhaps 2021 will begin to provide some answers.

The year at One Nucleus

As for all organisations, the disruption of the pandemic and the required adaptation to activities provided One Nucleus with challenges yes but also a chance to reflect on our strategy, consider how our members needs have evolved and evaluate where we focus resources into 2021 and beyond. The loss of face-to-face events changed to some degree how we delivered our events, profiled our members and region and channelled information to members. Changing Government guidance, new funding opportunities and indeed enabling peer-to-peer knowledge sharing were well received and leveraging our new-found confidence in online event delivery meant we engaged our international collaborators with our network much more actively.

Key delivery highlights include:

• Three conferences delivered - ON Helix, Genesis and Building Life Science Adventures. Collectively the events attracted over 1,000 registrants, 100 speakers and an impressive legacy of recorded sessions for continued on-demand learning. • Over 50 online events across topics in R&D innovation, funding, HR, marketing, collaboration and more.

• Delivery of online Training Courses, ensuring businesses were able to continue developing their teams through the pandemic. • Launch of our Virtual Innovation Centre. An initiative that was in the pipeline for One Nucleus long before we had to be more virtual due to Covid-19. • The Group Purchasing Scheme has saved our Gold members in excess of £3M in the past year and has also provide direct links to key suppliers such as Thermo Fisher who have worked with us to guide members through the pandemic and Brexit in terms of securing lab supplies. • Collaboration with our members has gone from strength to strength. The continued support and input from our sponsors and members has meant we have been able to create event content targeted at their information and engagement needs. On the flip side, our ability to offer members a 3-month extension to their membership year on renewal has been well received as our way to offer support in challenging times. • Relocation of the One Nucleus office to Babraham in May 2020 now seems a long time ago, but we look forward to maximising our presence there when restrictions are removed.

Looking Ahead with One Nucleus

As alluded to above, the year has provided space to develop our forward strategy, taking on board the guidance from members as we all move to the post-Covid brave new world. It is important to One Nucleus that we always align our approach as closely as possible to our mission and principles. It is all too easy for not-for-profit membership groups such as One Nucleus to suffer mission drift when they have been evolving over decades. Our mission remains the same, to support our members in being globally competitive, seeing great science and innovation translated into improved patient outcomes and value creation for all stakeholders. One Nucleus is fortunate to work with such an innovative ecosystem of members and collaborators that truly changes lives for the better. All parts of the ecosystem need to function and be innovative in what they do for the maximum collective impact.

That includes One Nucleus if we are to play our part fully. Supporting our members; facilitating knowledge exchange, connections and deal flow; and helping attract investment and talent to our cluster whilst minimising the overhead placed on our sector as they support us. This latter point is where we strive to be innovative, collaborative and adaptable. Looking forward, there are four key quadrants of One Nucleus activity and focus which are illustrated in overview here with further details later in the document and on the One Nucleus website.

Innovation Support People

• Promotion of Government support mechanisms • Connecting to the private investor base • Operational support and access to expert advice • Profile raising • Networking, partnering and business development • Facilities Management and Purchasing support • Special Interest Groups • Virtual Innovation Centre programme • Learning & Development course portfolio • Recruitment support • Careers events • Online job listings • ‘Employer of Choice’ sessions • People Pathways newsletter • On-demand learning centre • Skills Advisory Group • HR Special Interest Group • Patient/Research Charities Engagement Plan

Events

• Conference Portfolio - (ON Helix, Genesis, Building Life Science Adventures) • Innovation Seminars • Roundtables • Partnering Days • Collaborations • BioWednesdays • Networking Mixers • Company stats/R&D pipeline/investment • Promotion to inward investors and partners • Publication of commentaries & reports • Global exhibition/conference attendance • Stakeholder Engagement/Advocacy • Attracting Partnering Days • Building through collaborations

Regional Champion

Any Questions

Provoking good questions; connecting the best innovation; and working with the best partners is key to seeing patients benefit from scientific and technological advances. One Nucleus is fortunate and privileged to sit at the heart of such a world leading membership and network that strives every day to translate advances in biomedicine and healthcare into better healthcare interventions. I hope you enjoy reading our Annual Review, gaining the knowledge that helps you to identify the best route forward and the most suitable companions to take it with. Success is a team effort and the One Nucleus team very much looks forward to assisting you on your journey. Best wishes, Tony Jones, CEO

Supporting innovation is the raison d’être of a group such as One Nucleus. Irrespective of the stage of a company’s or project’s development, innovation sits at the heart of how to take that new product from bench to bedside. Innovation is not just about science and technology, creativity is equally valuable when arising in areas such as deal making, regulatory pathways and leadership styles such that the true benefit of great ideas is maximised for all stakeholders. Working with our members and collaborators to share knowledge, raise opportunity awareness and facilitate the right connections, supporting innovation is the common thread that runs comprehensively through all One Nucleus activities. Some of the key activities we undertake include:

Funding:

Accessing capital is of course critical to developing new products. As a membership-based organisation, One Nucleus does not provide investment capital or grants directly to life science businesses, but we do build connections and awareness of routes to capital and share this with our members. On-going tracking of available public sector schemes enables us to share that information with our members via our eNews, website and social media accounts. We nurture connections between private capital sources and our members, creating two-way awareness of opportunities. A recent development in 2020 has been venture funds, such as Advent Life Sciences and Cambridge Innovation Capital joining the One Nucleus Partner Programme to not only move themselves closer but also their respective portfolios to enhance both ecosystems.

Operational Support:

Leveraging the One Nucleus ecosystem to connect to expert advisers, special interest groups and practical facilities and purchasing support for those key roles within companies, means our members can focus on growth and the competitive edge of their approach.

Business Development:

Platforms to raise our members’ profile in the minds of partners, investors, customers and potential employees include our events, conferences, Annual Review, website and social media channels.

Virtual Innovation Centre

Launched in January 2021 this new initiative from One Nucleus is targeted at growth stage life science companies, many of whom will have benefited from the numerous start-up focussed accelerator and innovation centre models. Looking to their next stages, this precision support approach harnesses the global strength of our ecosystem and network, supporting leaders as they seek investment, partners and greater operational demands as illustrated below.

• 12-month tailored seminar programme. • 1-2-1 meetings with leading experts. • Profile at One Nucleus and external conferences. • Directed 1-2-1 introductions. • International connectivity. • Gold membership benefits.

Focus and news flow is often on highlighting world leading technology breakthroughs and impressive investment rounds and deals in the Life Sciences sector as life-changing products are invented and translated to improved patient care. It is vital not to forget the third pillar that supports the enviable track record, that inventions, collaborations deals and therefore impact requires people. One Nucleus supports members, individuals and the wider sector through a suite of interventions targeted to meet the aspirations of our members which can be summarised as follows:

Attract the best talent and skills. Engender loyalty. Harness the strengths of diversity Encourage innovation at all levels Be a good corporate citizen delivering value for all stakeholders. Motivate their employees. Operate an open and safe environment. Enable personal development of their staff. Deliver fair reward for performance. Offer flexibility to meet business and employee needs in an equitable manner.

Learning & Development:

Business leaders frequently confirm that their company’s employees are its most valuable assets. A mantra that has never been more relevant than now when competition for the best people has never been more intense. Retention and development of staff is as key to successful growth as effective recruitment. We have developed a range of Learning and Development support opportunities including: • A broad Training Course portfolio, delivered face-to-face or online to meet member companies’ needs. • Training Courses can be delivered in-house for a single company or open courses as required. • Members receive up to 30% discount on Training Courses when booking. • Free on-demand content from our events and conferences to fill knowledge gaps within teams.

Recruitment & Retention:

• Website listing of job vacancies. • Focussed ‘Employer of Choice’ sessions to discuss best practice. • Thematic forums in Skills and HR.

• Annual Building Life Science Adventures conference

People Pathways Newsletter:

• Monthly e-publication disseminated to our network. • Learning & Development insight articles. • Recent appointments at member companies. • Current vacancies.

• Up-coming Training Courses. For more information, please email our One Nucleus Learning and Development team

Connecting and meeting with peers is a vital part of business practice and our range of forums is designed to meet the needs of our network in terms of content, format, timing and modes of delivery. Our conferences and events provide the ideal platform for business-to-business interactions. The Covid-19 disruption forced us all to experience the shift to virtual events. Such enforced learning however does provide the opportunity to consider the benefits of new modes as well as what is missed. We aim to combine the best of both these meeting place worlds. Our events portfolio has both face-to-face and online events, in a balanced approach to share key information, debate emerging trends, generate new relationships and maximise accessibility to our community irrespective of geography. Future events will include: BioWednesdays: Monthly opportunities for a broad range of members and non-members to come together for peer-to-peer debate around current trends, challenges and opportunities within the sector. 2020 demonstrated these events worked extremely well online with high participation and discussion. They will remain that way, addressing the lost in-person networking by the means below. Networking Mixers: Our ‘Pub Socials’ started in April 2011 and have demonstrated a successful track record over the intervening decade. Bringing our network together in an informal manner to nurture relationships with contacts old and new. Networking is a powerful tool in business and many great deals, careers and ideas are forged in the bar! (Or over coffee, lunch or afternoon tea of course). Innovation Seminars: Built in partnership with our Partners and Sponsors, each event being a high content mix of presentations and/or debate around key technical or business challenges in the sector. These sessions, often free to attend and by invitation only, range from closed roundtable meetings to full-day seminars depending on the innovation journey under discussion. Partnering Days: Tailored in response to an innovation-seeking BioPharma corporate, these sessions create the platform by which their business development and technology scouting teams can engage with our network of early-stage R&D companies and institutions. Each one bespoke, they can contain one or more of corporate presentation and wish list, external expert speakers to stimulate engagement, 1-2-1 partnering and targeted follow-up mechanisms. Collaborative Events: Facilitating the convergence of our network with complementary networks from related technology fields or different geographies is an effective means to help our members build those all-important new relationships. One Nucleus maintains strong collaborative relationships with a multitude of such groups, both across the UK and internationally for just this sort of member-to-member connectivity with organisations like us. Conferences: The focal points of the One Nucleus events calendar, summarised overleaf. With free digital attendance for each One Nucleus member company, these larger gatherings provide the ideal opportunity to connect at scale. Our main events are: ON Helix - focussing on translational research and the ecosystems that enable it. Genesis – our largest annual event focussing on investment, technology development and deal trends in the sector.

Building Life Science Adventures – debating how great careers are created and nurtured in great companies. For more information, please contact Alicia Gailliez, Business Development Manager

Our flagship conference, ON Helix, brings our network together to present and discuss the main innovation and technology trends in healthcare research and development.

Following 2020 and the way the life science community combined resources, ingenuity and hard work to deliver prophylactic and therapeutic tools against the pandemic, many lessons can be learnt on better translating science and developing therapeutics and healthcare technologies.

Throughout the one and a half days of ON Helix, speakers will address the latest innovations and technologies in Medicines Discovery in a Brave New World.

Building on the evolution of the past 20 years, Genesis 2021 will assemble senior executives and decisionmakers from across the Life Science, Healthcare and Technology field to present, discuss and demonstrate their collective insight and thought leadership for the sector, themselves and their stakeholders.

• High content mix of plenary talks and panels from key opinion leaders • An Innovation Workshop area for further technical and business insights • Face to face networking and digital 1-2-1 meetings with delegates from across the international Life

Science and Healthcare industry • The Genesis Fringe Events Series • All One Nucleus member companies to receive one digital free pass

Creating careers not just jobs is a two-way process between those seeking to build their adventures in science and those seeking to employ them with academia a critical enabler. This two-day free to attend digital careers conference is a chance to fill knowledge gaps, debate best practice and connect to enable success. Not your standard job fair, this is an event bringing panels of students, early career seekers, employers and universities together to engage in lively discussions over the course of two days.

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