ACADEMICUPDATE DEPARTMENT/FACULTY

NEWS & SCHOLARSHIP

Selected Publications

BASIC & TRANSLATIONAL SCIENCES

NEWS/ACHIEVEMENTS

A selection of recently published work (Aug.-Dec. 2022) by department faculty/ researchers (indicated in bold).

Bawazir M, Amponnawarat A, Hui Y, Oskeritzian CA, Ali H Inhibition of MRGPRX2 but not Fc eRI or MrgprB2mediated mast cell degranulation by a small molecule inverse receptor agonist. Front Immunol. 2022;13:1033794. Epub 20221006. doi: 10.3389/ fimmu.2022.1033794.

Duran-Pinedo AE, Solbiati J, Teles F, Frias-Lopez J. Subgingival host-microbiome metatranscriptomic changes following scaling and root planing in grade II/III periodontitis. J Clin Periodontol. 2022. Epub 20221025. doi: 10.1111/jcpe.13737.

Gandy LA, Canning AJ, Lou H, Xia K, He P, Su G, Cairns T, Liu J, Zhang F, Linhardt RJ, Cohen G, Wang C. Molecular determinants of the interaction between HSV-1 glycoprotein D and heparan sulfate. Front Mol Biosci. 2022;9:1043713. Epub 20221107. doi: 10.3389/ fmolb.2022.1043713.

Jeon HH, Kang J (Co-author Dept. of Endodontics), Li JM (Co-Author Dept. of Orthodontics), Kim D (Co-Author Dept. of Orthodontics), Yuan G, Almer N (Co-Author Dept. of Orthodontics), Liu M (Co-Author Dept. of Periodontics), Yang S The Effect of IFT80 Deficiency in Osteocytes on Orthodontic Loading-Induced and Physiologic Bone Remodeling: In Vivo Study. Life (Basel). 2022;12(8). Epub 20220729. doi: 10.3390/life12081147.

Dr. George Hajishengallis, Thomas W. Evans Centennial Professor, was named on the Highly Cited Researchers™ 2022 list from Clarivate in the crossfield category. This is the third year in a row that he has been included in this recognition. The annual list identifies researchers who demonstrated significant influence in their chosen field through the publication of multiple highly cited papers during the last decade.

Dr. Myra Laird has joined the department faculty as an Assistant Professor. Prior to joining Penn Dental Medicine, she was an Assistant Professor in the Department of Integrative Anatomical Sciences at the University of Southern California Keck School of Medicine. She is an early career editorial board member with the American Journal of Biological Anthropology and has served as a guest editor for the Philosophical Transactions B Theme Issue ane A, Hunter K, Lee EL, Hyman D, Bross P, Alabd A, Betchen M, Terrigno V, Talwar S, Ricketti D, Shenker B, Clyde T, Roberts BW. Clinical characteristics and symptom duration among outpatients with COVID-19. Am J Infect Control. 2022;50(4):3839. Epub 20211113. doi: 10.1016/j. ajic.2021.10.039.

Dr. Laird is a member of the American Association of Biological Anthropologists, the American Association of Anatomists, and the Society of Integrative and Comparative Biology.

Chavakis T, Wielockx B, Hajishengallis G Inflammatory Modulation of Hematopoiesis: Linking Trained Immunity and Clonal Hematopoiesis with Chronic Disorders. Annu Rev Physiol. 2022;84:183-207. Epub 20211006. doi: 10.1146/annurevphysiol-052521-013627.

Chinipardaz Z, Liu M (Co-author Dept. of Periodontics), Graves DT (Co-author Dept. of Periodontics), Yang S Role of Primary Cilia in Bone and Cartilage. J Dent Res. 2022;101(3):253-60. Epub 20211108. doi: 10.1177/00220345211046606.

Chinipardaz Z, Zhong JM, Yang S Regulation of LL-37 in Bone and Periodontium Regeneration Life (Basel). 2022;12(10). Epub 20220930. doi: 10.3390/life12101533.

Daniele LL, Han JYS, Samuels IS, Komirisetty R, Mehta N, McCord JL, Yu M, Wang Y, Boesze-Battaglia K, Bell, BA, Du J, Peachey NS, Philp, N. J. Glucose uptake by GLUT1 in photoreceptors is essential for outer segment renewal and rod photoreceptor survival. Faseb j. 2022;36(8):e22428. doi: 10.1096/ fj.202200369R.

Daniell H, Nair SK, Esmaeili N, Wakade G, Shahid N, Ganesan PK, Islam MR, Shepley-McTaggart A, Feng S, Gary EN, Ali AR, Nuth M, Cruz SN, GrahamWooten J, Streatfield SJ, Montoya-Lopez R, Kaznica P, Mawson M, Green BJ, Ricciardi R, Milone M, Harty RN, Wang P, Weiner DB, Margulies KB, Collman RG. Debulking SARS-CoV-2 in saliva using angiotensin converting enzyme 2 in chewing gum to decrease oral virus transmission and infection. Mol Ther. 2022;30(5):196678. Epub 20211111. doi: 10.1016/j. ymthe.2021.11.008.

Gonzalez-Visiedo M, Li X, Munoz-Melero M, Kulis MD, Daniell H, Markusic DM. Single-dose AAV vector gene immunotherapy to treat food allergy. Mol Ther Methods Clin Dev. 2022;26:30922. Epub 20220716. doi: 10.1016/j. omtm.2022.07.008.

Grant MB, Bernstein PS, BoeszeBattaglia K, Chew E, Curcio CA, Kenney MC, et al. Inside out: Relations between the microbiome, nutrition, and eye health. Exp Eye Res. 2022;224:109216. Epub 20220827. doi: 10.1016/j. exer.2022.109216.

Hersh EV (Co-author Dept. of Oral/ Maxillofacial Surgery/Pharmacology), Wolff M (Co-author Dept. of Restorative Dentistry), Moore PA, Theken KN (Co-author Dept. of Oral and Maxillofacial Surgery & Pharmacology), Daniell H A Pair of “ACEs”. J Dent Res 2022;101(1):5-10. Epub 20211023. doi: 10.1177/00220345211047510.

Hu L, Xu Z, Fan R, Wang G, Wang F, Qin X, Yan L, Ji X, Meng M, Sim S, Chen W, Hao C, Wang Q, Zhu H, Zhu S, Xu P, Zhao H, Lindsey K, Daniell H, Wendel JF, Jin S. The complex genome and adaptive evolution of polyploid Chinese pepper (Zanthoxylum armatum and Zanthoxylum bungeanum) Plant Biotechnol J. 2023;21(1):78-96. Epub 20221007. doi: 10.1111/pbi.13926.

Kalafati L, Hatzioannou A, Hajishengallis G, Chavakis T. The role of neutrophils in trained immunity. Immunol Rev. 2022. Epub 20221003. doi: 10.1111/imr.13142.

Kolkhir P, Ali H, Babina M, Ebo D, Sabato V, Elst J, et al. MRGPRX2 in drug allergy: What we know and what we do not know. J Allergy Clin Immunol 2022. Epub 20220909. doi: 10.1016/j. jaci.2022.09.004.

Li Y, Yang S, Yang S Rb1 negatively regulates bone formation and remodeling through inhibiting transcriptional regulation of YAP in Glut1 and OPG expression and glucose metabolism in male mice. Mol Metab. 2022;66:101630. Epub 20221104. doi: 10.1016/j.molmet.2022.101630.

Nuth M, Benakanakere MR, Ricciardi

RP Discovery of a potent cytotoxic agent that promotes G(2)/M phase cell cycle arrest and apoptosis in a malignant human pharyngeal squamous carcinoma cell line. Int J Oncol. 2022;60(4). Epub 20220225. doi: 10.3892/ijo.2022.5331.

Occhialini A, Pfotenhauer AC, Li L, Harbison SA, Lail AJ, Burris JN, Piasecki C, Piatek AA, Daniell H, Stewart Jr. CN, Lenaghan SC. Mini-synplastomes for plastid genetic engineering. Plant Biotechnol J 2022;20(2):360-73. Epub 20211024. doi: 10.1111/pbi.13717.

Ribeiro AA, Jiao Y, Girnary M, Alves T, Chen L, Farrell A, Wu D, Teles F, Inohara N, Swanson KV, Marchesan JT. Oral biofilm dysbiosis during experimental periodontitis. Mol Oral Microbiol 2022;37(6):256-65. Epub 20221019. doi: 10.1111/omi.12389.

Shenker BJ, Walker LP, Zekavat A, Korostoff J (Co-author Dept. of Periodontics), Boesze-Battaglia K Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin-Induces Cell Cycle Arrest in a Glycogen Synthase Kinase (GSK)-3-Dependent Manner in Oral Keratinocytes. Int J Mol Sci. 2022;23(19). Epub 20221005. doi: 10.3390/ ijms231911831.

Thapaliya M, Amponnawarat A, Tesmer JJG, Ali H GRK2 inhibitors, paroxetine and CCG258747, attenuate IgE-mediated anaphylaxis but activate mast cells via MRGPRX2 and MRGPRB2. Front Immunol 2022;13:1032497. Epub 20221006. doi: 10.3389/fimmu.2022.1032497.

Uriarte SM, Hajishengallis G Neutrophils in the periodontium: Interactions with pathogens and roles in tissue homeostasis and inflammation. Immunol Rev. 2022. Epub 20221022. doi: 10.1111/imr.13152.

Wang H, Ideguchi H, Kajikawa T, Mastellos DC, Lambris JD, Hajishengallis G Complement Is Required for MicrobeDriven Induction of Th17 and Periodontitis. J Immunol. 2022;209(7):1370-8. Epub 20220826. doi: 10.4049/ jimmunol.2200338.

Yuan G, Yang S, Yang S Macrophage RGS12 contributes to osteoarthritis pathogenesis through enhancing the ubiquitination. Genes Dis. 2022;9(5):135767. Epub 20210826. doi: 10.1016/j. gendis.2021.08.005.

Zhu G, Chen W, Tang CY, McVicar A, Edwards D, Edwards J, Wang J, McConnell M, Yang S, Li Y, Chang Z, Li YP. Knockout and Double Knockout of Cathepsin K and Mmp9 reveals a novel function of Cathepsin K as a regulator of osteoclast gene expression and bone homeostasis. Int J Biol Sci 2022;18(14):5522-38. Epub 20220829. doi: 10.7150/ijbs.72211.

Endodontics

SELECTED PUBLICATIONS

A selection of recently published work (Aug.-Dec. 2022) by department faculty/ researchers (indicated in bold).

Aminoshariae A, Azarpazhooh A, Fouad AF, Glickman GN, He J, Kim SG, Kishen A, Letra AM, Levin L, Setzer FC. Tay FR, Hargreaves KM. Insights into the November 2022 Issue of the JOE J Endod 2022;48(11):1349-51. doi: 10.1016/j. joen.2022.09.009.

Aminoshariae A, Azarpazhooh A, Fouad AF, Glickman GN, He J, Kim SG, Kishen A, Letra AM, Levin L, Setzer FC. Tay FR, Hargreaves KM. Insights into the October 2022 Issue of the JOE J Endod 2022;48(10):1229-31. doi: 10.1016/j. joen.2022.08.007.

Aminoshariae A, Azarpazhooh A, Fouad AF, Glickman GN, He J, Kim SG, Kishen A, Letra AM, Levin L, Setzer FC. Tay FR, Hargreaves KM. Insights into the December 2022 issue of the JOE J Endod 2022;48(12):1455-7. doi: 10.1016/j. joen.2022.11.001.

Aminoshariae A, Azarpazhooh A, Fouad AF, Glickman GN, He J, Kim SG, Kishen A, Letra AM, Levin L, Setzer FC. Tay FR, Hargreaves KM. Insights into the September 2022 Issue of the JOE J Endod 2022;48(9):1089-91. doi: 10.1016/j. joen.2022.08.001.

Aminoshariae A, Azarpazhooh A, Fouad AF, Glickman GN, He J, Kim SG, Kishen A, Letra AM, Levin L, Setzer FC. Tay FR, Hargreaves KM. Insights into the August 2022 Issue of the JOE J Endod 2022;48(8):973-4. doi: 10.1016/j. joen.2022.06.011.

Atlas AM (Co-Author Dept. of Restorative Dentistry), Janyavula S, Elsabee R, Alper E, Isleem WF (CoAuthor Dept. of Periodontics), Bergler M (Co-Author Dept. of Restorative & Preventive Sciences), Setzer FC Comparison of loupes versus microscopeenhanced CAD-CAM crown preparations: A microcomputed tomography analysis of marginal gaps. J Prosthet Dent 2022. Epub 20220525. doi: 10.1016/j. prosdent.2022.04.008.

Lee SM Regenerative Endodontic Procedures: Management of Immature Necrotic Permanent Teeth Compend Contin Educ Dent. 2022;43(4):238-9. PubMed PMID: 35380859.