CiPD 2024 Symposium

3RD ANNUAL CiPD SYMPOSIUM

DENTISTS, SCIENTISTS & ENGINEERS TRANSFORMING ORAL HEALTH

Thursday, May 30, 2024

Penn Dental Medicine

University of Pennsylvania // Philadelphia, PA 19104

welcome

IT IS OUR GREAT PLEASURE TO WELCOME ALUMNI, FACULTY, STAFF, STUDENTS, AND FRIENDS TO THE THIRD ANNUAL CENTER FOR INNOVATION & PRECISION DENTISTRY (CiPD) SYMPOSIUM.

The CiPD Symposium will celebrate dentists, scientists, and engineers transforming oral health. We warmly welcome our guest speakers, Dr. Lawrence A. Tabak, Dr. Marylyn Ritchie, and Dr. Federico Mingozzi. Dr. Tabak, Principal Deputy Director of the National Institutes of Health (NIH), honors us by delivering the morning plenary, “The View from NIH: Many Challenges, Many Opportunities.” Dr. Ritchie, Vice Dean of Artificial Intelligence and Computing at the Perelman School of Medicine, University of Pennsylvania, will deliver the afternoon plenary, “Precision Medicine in the Era of AI.” Dr. Mingozzi, the chief executive officer of Stealth Biotech, will lecture on “A Personal Journey in Genomic Medicine from Lab Bench to Patient’s Bedside.”

Throughout the day, we will showcase CiPD faculty, trainees and students working on emerging applications in nanotechnology, microrobotics, AI, organ-on-a-chip, plant engineering, and drug delivery, from fundamental discoveries in microbiomics and tissue regeneration to new affordable therapies and diagnostic approaches. A poster session competition will be featured during lunch.

We hope you enjoy, interact, and help us move forward in addressing the unmet needs to transform the future of oral health care.

HYUN (MICHEL) KOO KATHLEEN J. STEBE

Co-Founding Director, CiPD Co-Founding Director, CiPD

INTRODUCTORY REMARKS

Hyun (Michel) Koo, DDS, PhD and Kate Stebe, PhD, CiPD Co-Founders/Co-Directors

8:45 am DEAN’S OPENING REMARKS // William W.M. Cheung Auditorium

Mark S. Wolff, DDS, PhD, Penn Dental Medicine

David F. Meaney, PhD, Penn Engineering

OPENING PLENARY // William W.M. Cheung Auditorium

The View from NIH: Many Challenges, Many Opportunities

9:00 am Lawrence A. Tabak, DDS, PhD, National Institutes of Health

CiPD FACULTY SPEAKERS AND TRAINEE LECTURES // William W.M. Cheung Auditorium

10:00 am Flavia Teles, DDS, PhD – Advancing Periodontal Care: Harnessing AI and Comprehensive Patient Data for the Prediction of Disease Progression

10:25 am Zhi Ren, DDS, PhD (Justin Burrell, PhD, Introduction) – Selenomonas sputigena: How a Motile Bacterium Influences Childhood Caries

10:40 am Coffee and Collaborative Discussion

11:05 am Ed Steager, PhD – Small-scale Robotics for Biomedical Applications

BIOINFORMATICS AND PRECISION MEDICINE // William W.M. Cheung Auditorium

Precision Medicine in the Era of AI

11:30 am Marylyn Ritchie, PhD, Artificial Intelligence and Computing at the Perelman School of Medicine/Penn Center for Precision Medicine/Institute for Biomedical Informatics

LUNCH: Poster Session Contest // Schattner Pavilion and Fonseca Garden

12:30-2:00 pm Hagar Kenawy, PhD – Poster Session Introduction

12:30 pm Lunch and Poster Presentation // Schattner Pavilion and Fonseca Garden Judges: Chider Chen, PhD, Simone Duarte, DDS, PhD, Geelsu Hwang, PhD, Jina Ko, PhD, Christopher Madl, PhD, Ed Steager, PhD, Flavia Teles, DDS, PhD

12:30-1:30 pm CiPD Trainees and Fellows Meeting with Lawrence A. Tabak, DDS, PhD

CiPD FACULTY SPEAKERS AND TRAINEES LECTURES // William W.M. Cheung Auditorium

2:00 pm Christopher Madl, PhD – Dynamically Tunable Soft Materials Platforms to Understand and Direct Tissue Regeneration

2:25 pm IDEA Prize

Kyle Vining, DDS, PhD – Presenting on the 2023 IDEA prize and awarding the 2024 prize

Brian Litt, MD – Recognizing Penn Health Tech’s IDEA prize support

2:50 pm Smruti Nair, DDS, DScD – Clinical Development of Plant Engineered Enzymes in Chewing Gums for Biofilm Inhibition and Disruption

3:05 pm Zain Siddiqui, PhD – Hybrid Biomaterials Strategies for Dental Pulp Regeneration

3:20 pm Coffee and Collaborative Discussion

3:45 pm Anh Le, DDS, PhD/Peter Quinn, DMD, MD – RESTORE prize announcement

4:00 pm Mousa Younesi, PhD – A Vascularized Mouth-On-A-Chip Model to Study Microbe-Host Interactions

AFTERNOON PLENARY // William W.M. Cheung Auditorium

A Personal Journey in Genomic Medicine from Lab Bench to Patient’s Bedside

4:15 pm

Federico Mingozzi, PhD, Chief Executive Officer of Stealth Biotech

5:15 pm CLOSING REMARKS AND RECEPTION // Schattner Pavilion and Fonseca Garden

Dennis Sourvanos, DDS, DScD

LAWRENCE A. TABAK, DDS, PhD

Lawrence A. Tabak, DDS, PhD is the Principal Deputy Director of the National Institutes of Health (NIH). He served as Acting NIH Director from December 20, 2021, to November 8, 2023. Prior to that Dr. Tabak was appointed as the NIH Principal Deputy Director and the Deputy Ethics Counselor in August 2010 following his tenure as Director of the National Institute of Dental and Craniofacial Research from 2000-10.

Dr. Tabak continues to lead an active research laboratory within the NIH intramural program studying glycoprotein biosynthesis and function in addition to his administrative duties.

Before joining NIH, Dr. Tabak was the Senior Associate Dean for Research and Professor of Dentistry and Biochemistry & Biophysics in the School of Medicine and Dentistry at the University of Rochester, New York.

Dr. Tabak is an elected member the National Academy of Medicine of the National Academies. He received his undergraduate degree from City College of New York, his D.D.S. from Columbia University, and a Ph.D. from the University of Buffalo.

MARYLYN RITCHIE, PhD, FACMI

Dr. Marylyn D. Ritchie is the Vice Dean of Artificial Intelligence and Computing at the Perelman School of Medicine, University of Pennsylvania. Dr. Ritchie is also the Edward Rose, MD and Elizabeth Kirk Rose, MD Professor of Genetics, Director of the Institute for Biomedical Informatics, Co-Director of the Penn Medicine BioBank, and Vice President of Research Informatics in the University of Pennsylvania Health System. Dr. Ritchie is an expert in translational bioinformatics, with a focus on developing, applying, and disseminating algorithms, methods, and tools integrating electronic health records (EHR) with genomics. Dr. Ritchie has over 20 years of experience in translational bioinformatics and has authored over 400 publications. Dr. Ritchie was appointed as a Fellow of the American College of Medical Informatics (ACMI) in 2020. Dr. Ritchie was elected as a member of the National Academy of Medicine in 2021; she is being recognized “for paradigm-changing research demonstrating the utility of electronic health records for identifying clinical diseases or phenotypes that can be integrated with genomic data from biobanks for genomic medicine discovery and implementation science.”

The mission of Dr. Ritchie’s lab is to improve our understanding of the underlying architecture of common, complex diseases. We develop and apply a breadth of translational bioinformatics approaches exploring the genome, the phenome, and the exposome. The approaches we take involve the development and application of new statistical, computational, machine learning, and AI methods with a focus on embracing complexity to uncover relationships between multi-omics data, clinical data (mostly from electronic health records), environmental exposures, and social determinants of health. These meta-dimensional approaches hold the promise of providing a more comprehensive view of genetic, genomic, and phenotypic information.

Dr. Ritchie is also interested in implementation of precision medicine into routine clinical care. Throughout her career, she has participated in research programs focused on the implementation of both pharmacogenomics and genomic medicine. Recent efforts are enriched in the concept of the Learning Health System, whereby they leverage the electronic health record linked biobank as a living laboratory to conduct research and then implement the findings to improve clinical care.

FEDERICO MINGOZZI, PhD

Federico Mingozzi, PhD is the Chief Executive Officer of a startup biotechnology company developing genome medicines. His career journey in gene therapy and immunology began in 2000 as a scientist in Philadelphia, working at the Children’s Hospital of Philadelphia and the University of Pennsylvania. Following this, he moved to France to take on the role of an independent investigator at the French National Institute of Health and Medical Research (INSERM) and the R&D institute Genethon. In 2017, he returned to Philadelphia, joining Spark Therapeutics as the Chief Scientific Officer.

Federico serves as the treasurer and a board member of the American Society of Gene and Cell Therapy (ASGCT). He is also a member of scientific advisory boards for non-profit organizations and biotech companies. In the past, he was a faculty member at Pierre and Marie Curie University in Paris, France, and the Universitat Autonoma of Barcelona, Spain. His educational background includes a bachelor’s degree in biology and a Ph.D. in biochemistry and molecular biology from the University of Ferrara in Italy. He also completed an M.B.A. at Drexel University.

T90R90 Advanced Training at the Interface of Engineering & Oral-Craniofacial Sciences