A Brief Description Of Pain Medications Pain medications, whether over the counter or prescription strength, can help you manage chronic pain and other types of pain. These are powerful drugs, so they should be used with caution. It's best to start with the safest drug at the lowest effective dose for the shortest amount of time and work up from there as needed. Be aware of possible side effects and interactions with other medications and supplements you take. Over-the-counter pain relievers include Acetaminophen and nonsteroidal antiinflammatory drugs including ibuprofen, naproxen, and diclofenac gel. Both acetaminophen and NSAIDs reduce fever and reduce pain caused by muscle aches and stiffness, but only NSAIDs can also reduce inflammation. Acetaminophen and NSAIDs also work differently. NSAIDs relieve pain by reducing the production of prostaglandins, which are hormone-like substances that cause pain and inflammation. Acetaminophen works on the parts of the brain that receive pain messages. Topical pain relievers are also available without a doctor's prescription. These products include creams, lotions, or sprays that are applied to the skin to relieve muscle and arthritis pain. Some examples of topical pain relievers include Asper creme, capsaicin cream, diclofenac gel, and Icy Hot.
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