What are the benefits of Nicotinamide Mononucleotide (NMN)

4. Benefits from Nicotinamide Mononucleotide(NMN)

NMN has numerous therapeutic functions and pharmacological effects on the human body. In less than a decade, scientists have dedicated their time to study all the Nicotinamide Mononucleotide benefits including the mechanisms that explain aging and the age-related ailments.

Let’s delve into the advantages of the compound in the human system.

(1) Lengthening the Cellular Lifespan

Up to the onset of the 21 st century, scholars had enough reasons to declare aging asan irreversible process. However, this notion has become void thanks to thecutting-edge discovery of anti-aging supplements like Nicotinamide Mononucleotide.

NMN is natural-occurring in the human cells and is responsible for the biosynthesis of

NAD+ and production of energy. As you grow old, these two compounds degenerate leading to regression of the stem cells. Remember, these functional units need enough cellular fuel to replicate continually, and therefore, a fall off will cut short the cellular lifespan.

Administering effective anti-aging drugs like NMN will reverse the process and delaythe aging mechanism.

(2) Upholding Youthful Cellular Energy Levels

The primary origin of the scores of ailments associated with aging is narrowed downto the cellular level. A decrease in the production of energy within the cells is themajor contributing factor of the old age symptoms.

Being a precursor of NAD+, NMN has a role to play in maintaining the optimal energy levels of the cell’s mitochondria. Aging will automatically cause a decline in the concentration of NAD+. As a result, the aging process momentarily picks up leading to the development of old age diseases.

A drop in the cellular energy levels within the vital organs such as muscles, blood vessels, kidneys, liver, or pancreas always interferes with physical and cognitive health. It’s for this reason that diseases such as ischemia, heart conditions, kidney failure, neurodegenerative disorders, and others shoot up.

The perfect solution is by supplementing the body’s Nicotinamide mononucleotide

and NAD+ with external NMN treatment. These anti-aging drugs give a new lease of life to the aging cells, which will then put on a youthful look.

(3) Improving Blood Circulation

One of the changes that occur during old is the decrease in the quality of the blood vessels within the mammalian body. Therefore, the circulatory system undergoes a lot of strain when carrying nutrients, oxygen, heat, or removing waste from the organs. Since the situation is persistent, it worsens over time leading to the occurrence of long-standing diseases.

Nicotinamide Mononucleotide is indirectly responsible for the production of bloodvessels. Allow me to explain. The compound synthesizes NAD+, which in turnactivates sirtuin deacetylase (SIRT1) protein.

Conversely, SIRT1 deacetylates lysine residues that aid in the production of oxygen free radicals. This mechanism fights against possible oxidative stress, reperfusion, or ischemic injuries. In typical cases, the body itself will endogenously counteract ischemia and the related conditions through ischemic preconditioning (IPC). IPC will then act to stimulate the production of SIRT1.

You can either administer NMN before an ischemic event occurs or during itsmanifestation. Before the occurrence, the compound offers cardio-protection byboosting ATP production through glycolysis.

In the case of Ischemia, you can still use Nicotinamide Mononucleotide as it will

trigger acidosis and cause mitochondrial impermeability; hence, guaranteeing the protection of the cardiac system.

(4) Muscle Endurance

What do you expect when the blood flow declines? Well, the state will lead to loss ofmuscle mass. It’s no doubt you’ll notice the old folks have less performance, lowendurance, immobile, and so much tired all the time.

One of the groundbreaking discoveries by Dr. Sinclair was centered on the efficiency of NMN in boosting muscle strength. According to his 2013 and the recent 2018 studies, old mice exposed to a seven-day NMN treatment became physically fit and active like their younger counterparts.

The muscle capacity and the endurance of the oldest mice (30-months old) were the same as those of a five-month-old youngling. These ages are comparable with approximately 70 and 20 years in humans. From the findings, you can infer that NMN work on human is sure as death.

(5) Combating Neurodegenerative Disorders

The brain is more like a powerhouse of your system. This aspect might be the reasonwhy medics will always rely on brain functions when declaring the time of death.

A reduction in the levels of NAD+ in the brain interferes with cognitive health among

the elderly. Administration of NMN accelerates NAD+ production, hence, protecting the neural functions.

Scores of studies prove that Nicotinamide Mononucleotide benefits cognition, stroke,and impedes memory loss, which is prevalent with old age. Summarily, this anti-agingsupplement is responsible for the maintenance of neurons.

NMN mainly targets the etiology of any given neurological condition. For instance, Alzheimer’s disease occurs due to a decrease in NAD+, a low rate of oxygen consumption in the brain, and mitochondrial abnormalities. Increasing the amount of NMN in the body counters all these effects.

According to a study published in 2012, Nicotinamide Mononucleotide will effectively manage intracerebral damage, which often leads to stroke. Old mice who were under NMN dosage registered significant improvement in the intracerebral NAD+ production. These research models had maximum protection against ischemic stroke, neural death, and neurological inflammation.

(6) Improved Metabolism in Old Age

Several researchers have studied and proved that NMN facilitates glucose tolerance while enhancing the metabolism of sugar on aging mice with a poor diet. This study also applied to aged humans who develop diabetes either as a result of high sugar or poor nutrition. Additionally, a diet rich in fat leads to insulin resistance.

Nicotinamide Mononucleotide maintains a peak production of NAD+, which in turn

reduces the age-related inflammation while improving the activation of insulin in fatty organs.

(7) Treatment of Diabetes

People with type II diabetes always exhibit resistance to insulin. This characteristic isdue to a falloff in NAD+. As a result, the cells undergo oxidative stress andinflammation. If you’re still young, the body will rejuvenate itself through some

endogenous physiological activities. However, with old age, NAD+ levels decrease in

the life-supporting organs like the skeletal muscles, liver, brain, and pancreas.

Another contributing factor to age-related diabetes is a high-fat diet. Abnormal amounts of saturated fats inhibit the biosynthesis of NAD+. In a bid to prove the efficacy of Nicotinamide Mononucleotide in the treatment of age and diet-induced diabetes, Yoshino and his colleagues used two mice models.

After administering a daily dose of NMN for close to 10 days, the scholars established that the mice, which were subjected to high-fat meals, recorded improved insulin intolerance. On the other hand, the diabetic mice showed significant improvement in hyperlipidemia.

(8) Reversing Aging

Chronic health complications always accompany the process of aging. As the body undergoes several physiological changes, some of the cellular functions happen to fall back. Take, for example, the levels of nicotinamide adenine dinucleotide decreases in multiple organs, leading to a decline in energy production by the cell’s mitochondrion.

Aging sets in motion various factors such as damaging of the DNA due to uncharged molecules, vascular oxidative stress, and other cognitive disorders. Do you know what happens? Well, there’s a DNA-repairing protein (PARP1) in the human system. In the case of DNA damage, NAD+ will activate this protein to repair the affected cell.

Several studies have come up with the nicotinamide mononucleotide benefits in

aging. For instance, Mills and his colleagues used mice models to investigate the effect of NMN age-induced physiological decline.

In the study, the researchers noted that long-term administration of the treatment led to the upregulation of the compromised genes within the liver, skeletal muscles, and the adipose tissue. What is more, the findings confirmed an improvement in the immune cell expression, an increase in lymphocytes, and activation of the leukocytes.

Another characteristic of aging is the presence of light-colored spots in the eye fundus. This condition together with bone density depletion and the inability to produce tears have been studied thoroughly on rodents. Scientists observed that mice, which were put on a 12-month NMN treatment, had all the above conditions reversed.

Longevity is the sole reason why people buy Nicotinamide Mononucleotide.

(9) Treatment of Obesity

For the elderly, NMN can reduce up to 10% of the initial body weight without finding the middle ground between appetite and growth. The pathological mechanism of obesity and diabetes are correlated. Low NAD+ levels bring about mitochondrial dysfunction; hence, a decrease in the production of ATP.

Obesity weighs down the potential of the mitochondria in generating ATP energy for

the cells. Once you administer Nicotinamide Mononucleotide, the drug will improve

glucose intolerance and other metabolic functions relating to obesity.

When it comes to improving the blood flow, NMN for obese treatment acts similarly to exercising. A single pill would be as good as using a treadmill daily. However, the difference comes in the levels of NAD+ content in the body organs. Whereas Nicotinamide Mononucleotide increases NAD+ in both the liver and muscular tissues, exercise only builds up the compound within the muscles.

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