Can Palmitoylethanolamide (PEA) powder help to loss weight ?

How does Palmitoylethanolamide (PEA) work?

Palmitoylethanolamide (PEA) exhibits vast mechanisms of action in its rolesuch as;

PEA usually targets the PPAR-α receptor (peroxisomeproliferator-activated receptor alpha). The PPAR- α is a receptor that acts as an

anti-inflammatory agent and also helps in burning fat and boosting metabolism.

When PEA binds to this receptor it helps in preventing the release of many substances that can lead to inflammation as well as genes associated with inflammation (Pro-inflammation genes). This hence helps prevent or lower inflammation.

Palmitoylethanolamide also works indirectly to induce the activities ofsome receptors such as the cannabinoid receptors. PEA indirectly stimulates the cannabinoid receptors (CB1 and CB2) by acting as enzyme (FAAH -fatty acid amide hydrolase)involved in the breakdown of the cannabinoid anandamide. This help in raising the levels of anandamide in our bodies, which is responsible for relaxation and combating pain.

Can Palmitoylethanolamide (PEA) powder help to lose weight?

Yes, Palmitoylethanolamide powder provides numerous weight loss benefits.Here are some of the palmitoylethanolamide weight loss benefits;

i.Palmitoylethanolamide improves metabolism

Palmitoylethanolamide (PEA) is able to bind to PPAR- α, a receptor responsiblefor metabolism, appetite, weight loss and fats burning.

When the PPAR- αreceptor is triggered you experience high energy levels which helps thebody burn more fats in exercises hence you lose weight.

ii.Palmitoylethanolamide can lower your appetite

Palmitoylethanolamide weight loss potential is demonstrated in its ability to influence your appetite. Similar to enhancing the metabolism, when the PPARα receptor is activated it leads to a feeling of fullness while eating thus helps you control the amount of calories consumed.

Further, PEA is considered a fatty acid ethanolamides that plays a key role infeeding behavior. In a study of overiectomized rats with high weight gain, PEA

supplement at 30 mg/kg body weight for 5 weeks was found to significantly

lower their food intake, fat mass and consequently the body weight.

iii.Palmitoylethanolamide anti-inflammatory effects during exercise

One may experience pain and inflammation during and after workouts due to excessive weight. Well, PEA supplement could help prevent this by stimulating anti-inflammatory activity of the PPAR- α receptor. Palmitoylethanolamide can also inhibit the release of inflammatory enzymes in the by the human adipose tissues.

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