CPL Vetnova

Specificity

One objection to the use of toxin binders is their potential side effects on feed components. It is true that some materials have been reported to be relatively unspecific adsorbents which may adsorb essential nutrients. As an exampl e, activated charcoal demonstrated adsorption capacity toward a broad range of mycotoxins in vitro, but also toward some vitamins and minerals. It is recommended to verify that the in vitro adsorption of macro and micro-elements of the product is minimal before selecting it. Respective adsorption percentages of vitamin B6 and phosphorus were less than 5% and 0% for the commercial product and 40% and 2% for activated charcoal A study aiming at evaluating the binding properties of a commercial product (ToxicareAdvance ) and activated charcoal toward vitamin B6 and phosphorus at pH 7, used a vitamin and minerals model. Respective adsorption percentages of vitamin B6 and phosphorus were less than 5% and 0% for the commercial product and 40% and 2% for activated charcoal. Toxicare Advance showed minimal risk of interaction with important elements from feed, conversely to activated charcoal. Curcumin induces drug metabolizing enzymes like gluthathione-s-transferase and induction of enzymes results in efficient detoxification of cytotoxic or carcinogenic compounds (Shalini and Srinivas, 1987; Soni et al., 1992.curcumin removes free radicals by producing a stable radical and thus its molecules that act as shuttle of scavengers for these radicals (Fanelli et al., 1985). This effect may be influenced in part by the nature of functional atomic groups present on the mycotoxin molecule. The other commonly used binding agents such as aluminosilicates, activated charcoal, bentonite, mannnanoligosaccharide etc. have been found to have varied effects on aflatoxin binding (Gowda et al., 2008), ochratoxicosis (Irina et al., 2007), fusarium toxicity (Yegani et al., 2006) and T-2 toxicosis (Raju and Devegowda, 2002). Andrographispaniculata , a well-known plant of Indian and Chinese traditional system of medicines, commonly known as Kalmegh has drawn attention of researchers in recent times. Andrographolide, the principal bioactive chemical constituent of the plant has shown credible anticancer, anti- inflammatory, angiogenic, antivenom, antidiabetic, xenobiotic potentially in various investigations around the globe. Recent understanding of xenobiotic detoxification operated MDR, which was conferred by ABC transporters with substrate specificity. it also find involvement of cytochrome P450 (CYP450) monooxygenase in xenobiotic detoxification, and furthermore the regulatory system of the ABC transporters and CYP450 regulated by a fungal specific-transcription factor in Sacromycies . thisestablishing a molecular mechanism for the regulation of antifungal/xenobiotic detoxification. Jung G 1 , Sang H 1 , Hulvey J2 , Chang T3 , Popko J L. rhamnosus is a type of bacteria found in your intestines. It belongs to the genus Lactobacillus, a type of bacteria that produce the enzyme lactase. This enzyme breaks down the sugar lactose L. rhamnosus, are considered probiotic. Probiotics are live microorganisms that can offer health benefits when consumed. Lactobacillus sp. Increased host immunity in gut by systemic immune response by secretion of IL-12, IFN Microorganisms metabolize complex food matrix and synthesize bioavailable and bioactive compounds leading to healthy consequences

Velocity of adsorption

The bioavailability of mycotoxins, correlated to their absorption on the digestive tract of the animal, is very diverse according to the type of mycotoxin and the animal species. In monogastrics, AFB1 and ZEA are rapidly absorbed in the proximal part of the digestive tract while other mycotoxins such as FUM are poorly absorbed. For the mycotoxins which are quickly absorbed, it is necessary to select a product which acts in a few minutes. An in vitro study aiming at verifying the binding properties toward AFB1 (1000 ppm) and ZEA (1000 ppm) of a commercial product Toxicare Advance ) after 1 min, 5 min and 10 min at pH 4, have shown that Toxicare Advance was efficient for speed of mycotoxins adsorption. Indeed, nearly 98% and 68% of AFB1 and ZEA were adsorbed with the commercial product after only 1 min.

Strict control plan of products

Finally, it is important to verify that the products are safe for animals, consumers and the environment. A strict control plan policy is mandatory with toxin binders which usually includes natural clays which are not risk-free, notably because of contamination to heavy metals or dioxins for example. A quality certificate is essential and represents a guarantee of product safety.

Making an informed decision

The five criteria which have been identified should be considered when selecting a mycotoxin binder product. These criteria participate to a better knowledge of the products, which are essential to satisfy feed manufacturer expectations i.e. a product with adsorption capacity toward a wide range of toxins, with fast adsorption, without desorption properties and which are safe for the animals. Also, economical aspects and favourable effects on animal health are considered. r

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