24 minute read
A Genomics Revolution
in the Midst OF the GenOMiCs revOlutiOn
We are in the midst of a revolution in Genomics: a revolution that will rival the major changes that occurred with the advent of the steam engine and the automobile and the incredible changes in communications represented by information technologies.
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Reality check: Is that just fanciful thinking? Is it perhaps wishful thinking? Or is the sentiment real?
Let’s start with some facts. A recent Batelle Institute report (published May 2011) stated that the Human Genome Project, which cost the American Taxpayer some $3.8 billion, has now resulted in over 300,000 jobs and a direct return on investment of almost $800 billion. Who says that you can’t make money in Biotech!
There is an argument to be made that in fact we have only begun to scratch the surface of the Genomics Revolution.
Coming back from the Davos World Economic Conference in 1998, then Financial Post Editor Diane Francis reporting on a presentation made by the president of Dupont, stated Biotechnology (read Genomics) will change the world as we know it: a) It will change the way we understand and treat many diseases such as cancer, Alzheimer’s and Diabetes; b) It will change the way we feed the world as we produce crops that are cheaper to grow and healthier to eat; c) It will teach us about the environment and allow us to live in a more harmonious fashion with our environment;
And each of these predictions are coming to pass.
The Genomics Revolution has resulted in untold discoveries pointing to the genomic and molecular basis of disease. We now have incredible insight into many of the most devastating diseases known to man including a number of different cancers, diabetes, Alzheimer’s and heart disease, and we’ve made huge strides in conquering an important number of infectious diseases such as HIV/AIDS. The future will hopefully see the realization of personalized medicine – the right medication at the right dose for the individual patient.
The Genomics Revolution has already changed our food supply in ways that few of us are aware. Over 80 per cent of the world’s supply of corn, soy, canola and cotton have been genetically modified to produce strains that are pest and/or pesticide resistant allowing for greater yields, and therefore keeping prices down. The enzyme pathway to produce Vitamin A has been introduced into the rice genome, which is already resulting in a significant drop in infant blindness in parts of the developing world. The Genomics Revolution is now starting to address one of the earth’s most diverse and interesting life forms. Over 85 per cent of the earth’s Biomass is made up of microbes that populate and control the environment of every corner of the earth including the deepest levels of the sea. For example, it is startling to note that there are 10x more microbes in our bodies than there are human cells. It is also clear that microbes have evolved over billions of years to function as “protectors of the environment”. Much work is being done to understand Microbial Genomics and determine how we might use these microbes to help clean up the messes that we have introduced into the environment. The oil sands, pollutants from mining and from burning dirty fuels are good examples.
The Ontario Genomics Institute (OGI) in partnership with Genome Canada and the Ontario Ministry of Research and Innovation, works to support Ontario’s world-renowned researchers in obtaining funding critical to their work and vital to enabling discoveries that bring immense benefits. We also work to assist in the commercialization of discoveries through our business development activities, and we also work to raise general awareness of genomics research, its importance and potential through educational outreach activities and public events.
Life changing research is already taking place in Ontario. Here are just a few examples: • Dr. Tom Hudson is a leading cancer researcher recognized internationally for his work on the International HapMap Project, an effort to catalogue human genetic variation. In 2006, he became the founding President and Scientific Director of the Toronto-based Ontario Institute for Cancer Research (OICR), which is dedicated to research in prevention, early detection, diagnoses and treatment of cancer. Since OICR was founded, it has launched several large-scale programs including the One Millimetre Cancer Challenge, the Cancer Stem Cell Program, the Pancreatic Cancer Genome Project, the Terry Fox Research Institute/OICR Selective Therapies Program and the High Impact Clinical Trials Program. Dr. Hudson’s laboratory at OICR is involved in the study of genome variation that affects cancer predisposition, progression, and response to therapy. His main project focuses on the genetic architecture of loci associated with risk to colorectal cancer.
• Dr. Steve Scherer is a senior scientist at The Hospital for Sick Children (SickKids), director of The Centre for Applied Genomics (TCAG) at SickKids, Director at the McLaughlin Centre for Molecular Medicine, University of Toronto, and professor of Medicine, University of Toronto. He is best known for his contributions to discovering the phenomena of global copy number variation (CNVs) of DNA and genes as the most abundant type of genetic variation in the human genome. With his group at SickKids and TCAG, he has discovered numerous disease susceptibility genes, including defining CNV and other genetic factors underlying autism.
• Dr. Aled Edwards is a structural biologist and director and CEO of the Structural Genomics Consortium (SGC), an open access public-private partnership that identifies new targets for drug discovery and places all the information into the public domain without restriction on use. The SGC determines the 3D structures of human proteins of therapeutical relevance to diseases such as cancer, diabetes, and many other disorders. To date, over 1200 structures have been determined and four Ontario-based companies and one long-term project has spun-out of this research, providing 867 SME jobs over the last decade – another example of how genomics is helping create new jobs and money for the province.
• Dr. Elizabeth Edwards is a professor in the Department of Cell and Systems Biology at the University of Toronto. Her research focuses on developing an understanding of how biological processes affect the fate of pollutants in the environment. She is currently heading up a project funded through Genome Canada, OGI and the province of Ontario that is sequencing and analyzing the genomes of many organisms to identify proteins with the potential to act as catalysts to transform wastes into useful bioproducts such as biofuel. Previous to this project and along with private sector partner Geosyntec Consultants, she developed a microbial culture that cleans up contaminated groundwater sites and that is sold world-wide.
• Dr. Steven Rothstein, professor at the University of Guelph, uses molecular genetics, biochemical and genomic information to understand problems in plant biology, which impact on the improvement of important crop plants. He has been involved in discovering new ways to get higher yields from Ontario corn, and more generally has worked towards uncovering ways to make crops resistant to environmental stresses like weather extremes. He is also looking at the economic and environmental cost of using large quantities of nitrogen fertilizer, specifically understanding the regulation of nitrogen metabolism with the long-term goal of generating the basic knowledge necessary to be able to improve the nitrogen use efficiency of crop plants.
• Dr. Paul Hebert, scientific director of the International Barcode of Life (iBOL) project at the Biodiversity Institute of Ontario, University of Guelph, is leading the iBOL project, currently the largest biodiversity project in existence. iBOL which unites researchers and biodiversity organizations from more than 27 countries, is working towards cataloging the world’s biodiversity by building a DNA barcode database containing DNA barcodes of more than 500,000 species. In addition to its importance in biodiversity, this work will greatly help: identify disease vectors; sift out marketplace fraud, such as mislabeling of foods; test animal feed purity; monitor climate change and detect invasive species.
So, you can see, important, game changing work is already being undertaken in our backyard, but the best is really yet to come. We are just at the start of this most important of revolutions – the Genomics Revolution.
Dr. Mark Poznansky is President and CEO, Ontario Genomics Institute
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liFe sCienCes OntariO
the Voice of Life sciences in ontario
liFe sCienCes OntariO MissiOn To represent and promote the benefits of life science technologies and encourage their commercial success including related organizations that support this community. We do this through advocacy, facilitation of economic development and promotion of our industry locally, nationally and internationally.
The life sciences sector in Ontario is diverse, ranging from pharmaceutical and biotechnology to agriculture (including livestock and plants), forestry, food and food processing, bioeconomy and the environment. This great diversity has lead to immense opportunity for the province, but has also lead to challenges in providing consistent messaging to policy makers and stakeholders, who in turn need to react to business, social and political realities. As each of us know, individual companies or groups have more limited influence and impact because they don’t represent a strong, collective voice.
Life Sciences Ontario (LSO) was founded on the basis of providing a unified voice for life sciences in Ontario and has been recognized by the Government of Ontario as a key stakeholder in the future economy of the province. Life Sciences Ontario is not only impacting the directions and resolutions of public policy in Ontario but is also acting as a conduit between the many organizations in Ontario and the governments that operate in our space. This organization has the mandate to develop cross-sectoral connectivity across the province with the vision to provide opportunities for like-minded groups to act with one voice, ultimately contributing LSO has been interacting with several government institutions and ministries to raise awareness of our common and diverse needs.
By taking leadership in policy management, LSO is providing its members direct benefit and opportunity to be informed of key challenges (for example – increasing investment into the sector). This is done through communications and events designed to keep members at the cutting edge of industrial, policy and overall sector impact. Similar to the Autumn of 2010, LSO will be convening an investment summit in 2011, with the task of further supporting the economic vitality and health of the industry.
LSO is working with the Ontario Government to have a deeper understanding of the economic importance of life sciences in Ontario. LSO will collaborate on an asset map of the breadth of the sector in Ontario. The community’s strengths will be analyzed, communicated, and showcased globally from these efforts. Future priorities for LSO to help align with Ministry priorities will be formalizing and enhancing a united voice for the community through collaboration with the many entities representing life sciences in Ontario; and forging strong relationships with Quebec to create a strong Ontario-Quebec corridor of life sciences that is globally competitive to the top jurisdictions in this space.
Life Sciences Ontario provides stakeholders, including government, academia industry and NGOs a single entity to address significant and challenging matters and concerns. It adds value to its members by providing a united and loud voice to address the many issues that affect our industry today, making this sector more attractive to investment, corporate and plant localization, ultimately enhancing the profitability of life science companies in Ontario.
to positive economic development and policy initiatives. It truly represents the life sciences community in Ontario with members of all sizes representing research, commercialization, support, manufacturing and production, and services sectors.
Life Sciences Ontario is also collaborating across the many life sciences groups, including regional innovation centres (RICs), provincial industry groups, economic and business development groups, to address issues that are fundamental to the success of the province. This united effort will lead to an enhanced quality of policies and policy development for the sector.
Each group and sector in life sciences has unique challenges, however, we also share common challenges particularly with the protection of intellectual property, regulatory, financial and investment challenges, and finally commercialization of the innovative products developed. In order to best represent the needs of our members, the LSO Board of Directors has executive level representation from across the province representing pharma, biotech, agriculture, food, and biochemistry, with direct linkages into the auto manufacturing and chemical sectors. With its expertise and strong leadership
COMMerCializatiOn suCCess OBest™
the ontario bioscience industry plan
With the global economy still in recovery two years after the economic downturn, Ontario’s bioscience industry and a universe of pan- Ontario stakeholders’ seized the opportunity to contribute to Ontario’s economic growth and developed a comprehensive, implementable plan for a vibrant biosciences industry. Developed by OBIO, the plan is named, OBEST (Ontario Bioscience Economic Strategy Team) and articulates industry’s collective mandate for sustainability, growth and long-term prosperity.
In OBIO’s 2010 and 2011 industry status reports, senior industry executives described the constraints on their ability to develop and commercialize products. Issues confronting industry included difficulty raising external fi nancing, fi nding technology partners and funding research. Industry executives recognized the need to develop a comprehensive bioscience industry plan if Ontario’s industry was to deliver on its full potential to provide innovative health care solutions and the concomitant economic benefi ts.
Ontario is home to world-class research which provides the raw ingredients for innovation, from a strong professional services sector to a highly educated work force, and is poised to take advantage of the knowledge economy. To be implemented over the next three years, OBEST completes the virtuous cycle (Figure 1) in which commercially successful companies turn Ontario’s sizeable investments in education ($22 billion in 2010) and R&D ($3.6 billion since 2004) into high-value jobs, anchor companies, the adoption and export of innovative healthcare solutions, and increased investment.
Ontario companies are engaged in research and development of new therapeutics and products which promise enhanced opportunities for maintenance of health, through better diagnosis and treatment of illness. Approximately 100 small and medium-size companies are working on: stem cell therapies; cancer therapies; genomics; biomaterials; novel formulations; biosimilars; diagnostics; bioinformatics and devices. Approximately one third are engaged in early R&D; another third in clinical trials and the other third are either market-ready or generating revenues. Most companies are private; pre-profi t and employ fewer than 10 employees.
Starting in the fall of 2010 and concluding early in 2011, over 200 stakeholders from across the province rolled up their sleeves and went to work as part of the OBEST project. Collectively, they dedicated more than 5,000 volunteer hours working in regional groups to advance a strategic plan which establishes industry’s goals, strategies and implementation tactics (Figure 2). Participants in this concentrated effort represented: universities, colleges, three levels of government, research institutions, hospitals, fi nancial and capital markets, patient groups, pharma, bioscience companies and other industry stakeholders. Their concerted collaboration demonstrates the mutual interdependence of stakeholders in creating a plan for the industry to fl ourish.
Consistent with OBIO’s operating principles, the OBEST process was open, transparent and democratic. An e-room provided participants with
Continued on page 38
Figure 1. ontario bioscience econoMic enGine
Adoption & Export of Healthcare Solutions Government Investment in R&D and Education
High-Value Jobs
Attract Investment
Anchor Industry & Spin-o Ventures Figure 2. obest strateGic process
Continued from page 28
sauga and the town of caledon. Mississauga is home to the third largest life sciences cluster in canada with more than 375 companies employing approximately 24,800 people. baylis Medical is a local success. baylis Medical is a leading developer, manufacturer and supplier of high-technology medical devices for interventional pain management, interventional cardiology and radiology products. ricc has supported the growth of baylis Medical through their entrepreneur-in-residence program, assigning a coach and mentor to provide them with high-level special guidance on commercialization of technologies.
Website: www.riccentre.com
niagara interactive Media Generator (nGen) is a hub for interactive digital media project and business development in the niagara region. as a new member of one, nGen has expanded its mandate via the regional innovation centre (ric) to include the support and development of the emerging industry clusters as identified in niagara’s economic growth strategy. these industry clusters include digital media, health and wellness, green energy, and bio-products. niagara has many unique competitive advantages perfectly suited to the emerging bio-economy. these include a longestablished agricultural and agri-food business infrastructure, institutional bioscience research, industry expertise drawn from a number of leading-edge companies, and abundant supplies of talent, water, energy and biomass. collectively, these assets have helped attract businesses in a variety of growing sub-industries within the bio-products field such as waste-to-energy conversion, pharmaceutical product development and manufacturing, and industrial fermentation. as a part of the one network, nGen can align bio-products companies and entrepreneurs with valuable resources and services available in niagara and ontario. nGen facilitates networking, collaboration, prototyping, production and business development for the emerging industry clusters in niagara. its main activities revolve around mentorship, access to technology, projects, seminars, networking, and tenancy for digital media companies. it works to create an innovative business incubation and generation model to help jump-start and grow new enterprise.
Website: www.ngen-niagara.com
We-Tech Alliance, Windsor, ON
Wetech alliance is Windsor-essex’s technology accelerator; an industry-led non-profit organization focused on driving the growth and success of Windsor essex’s technology centric companies & entrepreneurs through leadership, connections and promotion. Wetech strives to identify, find solutions and foster the development of the technology industry in Windsor essex by engaging companies in the technology and innovation sector, as well as companies who utilize technology. the Wetech mission is to nurture innovation and technology by providing the tools, programs, resources and support that entrepreneurs and technology-centric companies require for sustaining growth, development and success.
Wetech assists entrepreneurs in launching new ventures, providing education and networking opportunities to accelerate business growth for small-to-medium enterprises, and serves its members as advocates for the region’s thriving technology and innovation companies.
Website: www.wetech-alliance.com
MaRS Discovery District, Toronto
Mars Discovery District is a large scale, mission driven innovation centre located in toronto, focused on building canada’s next generation of technology companies. opened in 2005, Mars seeks to find a “better way to capture the commercial potential of toronto’s $1 billion in annual science and technology research spending.” since opening, Mars has advised more than 1200 start-up companies on how best to commercialize their technologies.
Mars works closely with entrepreneurs in life sciences and health care; information technology, communications and entertainment; cleantech; advanced materials and engineering; as well as innovative social purpose businesses. the core “engine room” at Mars is the advisory services group. our advisors and associates assess our entrepreneurclients’ needs, work with clients to develop the best paths for their businesses and, ultimately, provide the support they need to reach their goals.
Mars also offers educational resources, including the entrepreneur’s toolkit, an online collection of articles, templates and workbooks, as well as in-person educational programs and lectures from thought leaders and industry associations. through one, Mars also provides free market intelligence to ontario technology entrepreneurs, allowing them to make informed decisions about market size and industry opportunities. Mars provides resources — people, programs, physical facilities, funding and networks — to ensure that critical innovation happens. Mars stimulates, identifies and harnesses great ideas, nurtures their development and guides the transformation of those ideas into reality.
Tech Alliance of Southwestern, London, ON
techalliance empowers London and southwestern ontario’s technology sector. as a member of the ontario network of excellence (one) we prepare today’s entrepreneurs to launch new ventures, provide education and networking opportunities to accelerate business growth for small-to-medium enterprises, and serve this community as advocates for thriving technology, life sciences and advanced manufacturing companies. our business services team is here to help you start and grow your technology company and improve your chances for success. our services are available to all start-up and early-stage companies and entrepreneurs in the region.
Whether you have a company or just an idea, our in-house team of experienced analysts, advisors, and entrepreneursin-residence will work with you to understand your tech business and the challenges you face, and to help you access all the resources available to high-potential tech businesses in the area. techalliance also plays a major role
in the southwestern ontario regional alliance, a gathering of organizations striving to enhance our entrepreneurial community; members include techalliance, WorLDiscoveries, the research park (London, sarnia-Lambton), ontario centres of excellence (oce), national research council of canada (nrc), Wetech alliance (Windsor-essex). this unified approach enhances the collaborative element of techalliance’s service offerings and ensures we continue to work with innovative groups to promote a supportive network for business growth in London and southwestern ontario.
Website: www.techalliance.ca
Innovation Guelph-Guelph
innovation Guelph is a social enterprise sponsored by the Guelph chamber of commerce and funded through the ontario Ministry of research and innovation and Mars. the mission of innovation Guelph is to help enterprises start, grow and thrive. innovation Guelph has a broad reach, but typically focuses on projects that fall into five sectors: advanced manufacturing and engineering, life sciences, clean tech, information technology and social innovation. innovation Guelph does not offer funding directly, however, it aims to act as a clearinghouse and keep track of opportunities for private and public investment. two examples are: ontario centres of excellence: offers the potential for funding of private sector research needs by ontario universities; and the angel investor networks: if you are seeking private investment innovation Guelph can assist in both connecting with and preparing for presentations to angel investor networks.
Website: www.innovationguelph.ca
the innovation Durham northumberland (iDn) is an industryled non-profit organization providing technology commercialization services contributing to the growth of both the Durham region and northumberland county. the iDn has three locations: Durham college Whitby campus, University of ontario institute of technology (Uoit) in oshawa and the northumberland Manufacturers association (nMa) offices in cobourg. the iDn provides innovators, technology based businesses, entrepreneurs and researchers with services and programs to help them innovate and gain a competitive advantage. the iDn will draw upon the resources of Mris business acceleration program (bap) and the ontario centres of excellence to deliver its program and services. initially the iDn will focus on providing services to companies in the following sectors: energy, information and communications technology (ict), advanced manufacturing, and environmental products and services.
Website: http://www.innovation-dn.ca
The VentureLab, Markham
VenutreLab is the York region partner in ontario’s network of excellence and is located in Markham, canada’s high tech capital. the regional Municipality of York has a long history of innovation in knowledge based industries and has significant regional assets. it has a deep talent pool with close to 70 per cent of its adult population with post secondary degrees or higher and a strong entrepreneurial culture. VentureLab realizes the significant value of education and learning in this knowledge-based economy. We strive to provide educational programs and encourage collaboration from this generation’s young entrepreneur’s right through the entire entrepreneurial life-cycle. VentureLab offers services to ict and Life science entrepreneurs in helping bring their technology to market. We have many strategic advantages including ventureLab’s ability to connect with industry partners and to bridge relationships among the business, academia, science and government sectors.
Website: www.venturelab.ca
Communitech Technology Association Inc., Waterloo
communitech is a not-for-profit organization with close to 15 years of experience helping technology entrepreneurs in Waterloo region grow their businesses. recently, the organization expanded its focus to share its best practices, facilitate innovation and strengthen technology companies at a provincial and national level (driving the creation of the canadian Digital Media network.) in addition to seeding and growing young technology companies throughout the region, it is focused on connecting and bringing value to its 600+ members. it does this by way of numerous events, peer learning & development programs. from funded, mature companies to one-person start-ups, the organization works with hundreds of clients.
Website: www.communitech.ca
HalTech Innovation Centre, Oakville
Halton region, in partnership with communitech technology association is establishing Haltech, Halton’s own regional innovation centre (ric). During this formation stage, Halton region and communitech will be providing a base level of business support services for the innovative community in the region.
Website: www.venturelab.ca
Northern Technology Alliance-North Bay, Sudbury, Thunder Bay, Sault Ste. Marie
the northern technology alliance which is a collaborative network of organizations from across the major centres in northern ontario designed to help clients commercialize their ideas. the northern technology alliance is made up of members norcat (sudbury), the sault ste. Marie innovation centre (sault ste. Marie), the northwestern ontario innovation centre (thundery bay) and innovation initiatives ontario north (north bay).
Website: www.norcat.org; www.ssmic.com; www.nwoinnovation.ca; www.iion.ca
Continued from page 34
meeting minutes, presentations and background reading materials. OBEST participants prioritized strategies which take a holistic approach to the sector and strengthen links among all participant groups. A strong focus exists for links between commercial companies and universities and research centres. As well, links are created with groups like the Structural Genomics Consortium and emerging models such as the Center for Commercialization of Regenerative Medicine (CCRM). For example, CCRM brings together experts from several Ontario research institutes to accelerate regenerative-medicine research and development and create a commercialization pipeline that rapidly brings regenerative-medicine technologies to market. Other strategies focus on securing and retaining investment, attracting new industry partners, working with global pharmas on common regulatory and market access challenges and partnering with government to identify and meet the needs of future healthcare priorities.
OBEST has delivered a road map for establishing biosciences as a key element of Ontario’s future economic engine and a solution to Ontario’s health care needs for innovation and cost effectiveness. With a plan in place, the bioscience industry, academia, government, healthcare providers and consumers can work effectively to make Ontario competitive abroad and an inspiring place to live, learn and work. Together, we have created the blueprint for growth and sustainability of a sector critical to a knowledge economy. Implementing that plan together, we will create an environment for success, a critical mass of commercial winners, where the value of setting up a bioscience company and remaining in Ontario is globally recognized. This will be our shared legacy.
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