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fragments. Limitations of LC/ MS/MS are that the instrument is expensive, operation of the instrument is complex and even when operated in a highly targeted manner, it is not as sensitive as ligand binding assays. LC/MS/MS can be set up to accomplish a number of different activities at once such as provide impurity information, identity and quantitation all within a single experiment.

LC/MS/MS can also be used to identify oligonucleotides by providing both the mass and sequencing the oligonucleotide.

Absorption Spectroscopy

is a very quick and inexpensive approach to monitoring total protein concentration. Prior to putting the sample on the spectrophotometer, there are a variety of sample treatment approaches (including the Bradford assay, Lowry assay, BCA assay) that when these reagents are combined with peptides/proteins, it leads to a change in the absorption of the sample and the intensity of the absorbance at the measured wavelength provides quantitative information. Advantages of this approach include that it is a quick and cost effective measure of determining protein quantity. Disadvantages include that the approach lacks specificity and cannot differentiate between proteins, and thus require the sample to be very pure to be able to determine the concentration of the protein of interest. The technique provides no information regarding the identity of the protein or peptide, and measures total protein concentration, not specifically the analyte of interest.

Although absorption ratios of different wavelengths can provide some insight into the purity of DNA or RNA sample, this approach cannot provide close to the same level of purity information as gel electrophoresis, HPLC or CE.

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Activation Laboratories Ltd is a contract analytical laboratory that specializes in analytical testing services and analytical method development services of metals, small molecules and large biomolecules. ABOUT THE AUTHORS: Michael Hoffman PhD MBA is director of biotechnology and bioanalytical services for Activation Laboratories Ltd and has extensive experience in protein based analytical techniques; Steven Jenkins PhD, is a senior R&D scientist at Activation Laboratories Ltd and has extensive experience in separations strategies and mass spectrometry; Paul Tressel PhD, is a senior R&D scientist and has extensive experience in biomolecule analysis; Mona Raita MSc is a Senior Research Scientist at Activation Laboratories Ltd and specializes in ligand binding assays and oligonucleotide assays; and Katie Moyer PhD is a Senior Research Scientist at Activation Laboratories Ltd and specializes in oligonucleotide and DNA based techniques.

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NEW PRODUCTS

Simplette Straws

Seward Limited new universal fit Simplette Straws are designed for use with fixed or variable-volume pipette handsets and provide an alternative to graduated pipettes for sample handling applications. With their increased wall thickness and extended length, the Simplette Straw has been designed specifically to reach the bottom of all Stomacher® bags. This means that a homogenised sample can be readily recovered for microbiological inoculations without risk of cross contamination via the pipette handsets, since they have no contact with the bag. They come packaged, irradiated and are available in two lengths, 170mm and 250mm. Reply Card #4360

Nexxis ST

Labtronics Inc. announces the release of Nexxis ST (Sample Tracker) 5.0, a sample management module used with Nexxis iLAB. Nexxis ST 5.0 meets the needs of customers who have a requirement for sample management but don’t require a full blown LIMS. It is an affordable out of the box system for storing and tracking test results. The sample tracker is highly integrated with other Nexxis iLAB components. Sample information and test results can be automatically exchanged with instruments. As samples are logged into Sample Tracker they can automatically initiate and schedule Nexxis ELN worksheets for their analysis. Raw data can be stored in an SDMS such as Nexxis SDMS, and each sample can be provided with a direct link back to the raw data. An analyst can now review the test results and instantly open a viewer to examine the raw data. Nexxis ST uses ReDITM technology to provide user configurable sample login screens. Each sample type can have a different login screen allowing you to track different information for each type of sample. Nexxis ST 5.0 is a zero foot print web application that can be run from any PC, including wireless devices. Reply Card #4361

Automated Synthesis Systems

Syrris has developed optional upgrades to its range of Atlas automated synthesis systems. The introduction of new stainless steel reactors and a high temperature upgrade kit has increased system flexibility, making the Atlas product range suitable for a broader spectrum of applications.Using the same jacketed vessel clamp, oil drain unit and fluid pipe connectors as the Atlas Potassium system, the standard glass vessel can be effortlessly exchanged for the stainless steel version in under a minute. Available in a range of sizes from 100 ml to 5 L, an integrated bottom outlet valve compensates for any thermal expansion, while the torispherical profile and consistent length to diameter ratio mimic the dimensions of largescale plant reactors. Ideal for use with sodium hydroxide and other highly basic substances that would etch glass, the incorporation of the stainless steel vessel further increases the flexibility and usability of the Atlas range. The development of a new temperature upgrade kit has also enabled the Atlas glass or stainless steel jacketed reactors to increase the existing temperature range of -80 to +200 °C, to allow a limit of +250 °C, making it suitable for high temperature applications. All upgrade parts are easily installed by the user, without the need for any tools. Reply Card #4362

Connector System

Dolomite introduces its new Mitos In-line Connector System. This innovative connector provides a single, fast and reliable multi-way connection, which offers extensive time savings when compared to traditional connections between individual pipes. In addition to being quick and easy to use, the Mitos In-line Connector provides in-line sealing and highly accurate alignment between the tubes, enabling uninterrupted liquid flow. Available in three standard sizes 4-, 8- and 12-way, the Mitos In-line Connector operates over a wide temperature (-15 0C to 250 0C) and pressure range (up to 10bar), providing excellent chemical compatibility. Furthermore, a low dead volume reduces the risk of cross-contamination between fluid samples, thereby maintaining experimental integrity. It is compatible with a variety of polymeric tubes including PTFE, FEP and PEEK. Custom sizes and geometries are also available upon request. Reply Card #4363

Meter Scanner

Omega has launched the wi-8 series, a new wireless meter scanner and controller. This new series of wireless monitoring and control system is highly compatible with a wide range of Omega wireless sensors including the UWTC, UWRTD, and z series. Compact in size and simple to configure, this product can monitor up to 8 wireless sensors. Wireless inputs for this product include thermocouple, RTD, temperature, humidity, and barometric pressure. The wi-8 series comes standard with a choice of either two form c relays, or two SSR’s (solid state relays) that can be used for control functions or alarms. Monitoring can be done locally or through an embedded Ethernet or Internet connection without any additional software other than a web browser. Reply Card #4364

Volumetric

JM Science’s AQUACOUNTER® Volumetric Karl Fischer Titrator (AQV-300) is reliable, easy-to-use and has performance features allowing measurement of moisture content from low to high concentrations quickly and accurately. Measurements are simple and routine with unsurpassed precision. The AQV-300 has six built-in calculation modes to accommodate solid, liquid and gas samples. It includes a statistics package with one-touch calculations. Four files with preset conditions can be stored in memory and allows instant recall of data for up to 20 samples. A built-in detector monitors titration status and a direct key access allows entry of titration parameters. This compact unit with a very small footprint has balance and computer interfaces for GLP and ISO documentation. Includes download software for transferring results to a laptop or PC. Choice of thermal printer or impact printer is also available. Reply Card #4365

NEW PRODUCTS

Ultra High-mass Applications

Shimadzu Scientific Instruments has partnered with CovalX to offer the AXIMA MegaTOF™, an integrated MALDI solution for ultra high-mass applications, including protein complex characterization, therapeutic protein aggregates, antibody-antigen interactions, polymer analysis and high mass bioimaging. The high-sensitivity MegaTOF, combines a high-performance Shimadzu linear MALDI TOF mass spectrometer with a CovalX high-mass detection system and detects macromolecules up to 1,500 kDa. When analyzing intact protein complexes by high-mass MALDI TOF, it is crucial to stabilize the complexes with highly efficient crosslinking reagents. In addition, existing Shimadzu AXIMA MALDI systems (Assurance, Confidence and Performance) can be retrofitted with CovalX’s HM2 or HM2 TUVO high-mass system. Reply Card #4366

Mass Spectrometers

Waters Corporation introduces two new mass spectrometers for its Xevo MS platform – the Xevo TQ-S and Xevo G2 QTof – that bring a step change in performance to benchtop mass spectrometry. Combined with Waters® ACQUITY® UltraPerformance LC® (UPLC®) systems these mass spectrometers offer scientists a combination of separation power with highest levels of sensitivity whether for compound identification, quantification, and screening, or for extracting the most information from the smallest sample volumes all in a single analysis. Reply Card #4367

COMPANY & ADVERTISER INDEX

COMPANY PAGE RC

Allostera Pharma Inc.........................6......................... Association for Laboratory............................................ Automation ......................................2......................... Caledon Laboratory Chemicals ........5.................4356 Canadian Institutes of Health Research .......................6 Cangene Corporation ........................7......................... CardioComm Solutions ......................6......................... Carmichael Engineering .....................7......................... Chemical Institute of Canada...................................... and the Canadian Society........................................... for Chemical Technology .................4.................4355 Centre for Drug Research ............................................ and Development..............................7......................... Children’s Miracle Network............6.................4369 Cyplasin Biomedical...........................7......................... Cytochroma .....................................7......................... Dolomite.........................................15................4363 Fisher Scientific..............................2.................4354 Helix BioPharma Corp. ......................7......................... Immunovaccine Inc............................6......................... JM Science.....................................15................4365 LAB Research Inc. ............................7......................... Labtronics Inc. ................................15................4361 McGill University ..............................3......................... Medicago Inc....................................7......................... Millipore .......................................20................4367 Omega.............................................5.................4364 Ontario Genomics Institute................4......................... PriceWaterhouseCoopers Inc.............7......................... Retsch............................................7.................4357 Sanyo ............................................19................4368 Shimadzu Scientific Instruments........16................4366 Society for Biomolecular Sciences ......2......................... Seward Limited................................15................4360 Syrris.............................................15................4362 Theratechnologies Inc. ......................6......................... Trent University................................1......................... Vancouver Prostate Centre ...............7......................... VWR ..............................................11................4358 Waters Corporation .........................16................4370 Wyvern Scientific Inc.....................14................4359 Xenon Pharmaceuticals Inc. ...............6......................... YM Biosciences ................................6.........................