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Chondroitin (Andrew Hess, Purdue College of Pharmacy
Chondroitin
What to expect
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For preventative care, may notice improvement in joint health within a few weeks. If taking to repair existing joint damage, may need to take chondroitin for two to three months before any notice of improvement.
As of yet, evidence supporting the efficacy of chondroitin is mixed.
More high quality studies are needed for a reliable conclusion. Safety
Most reports conclude that chondroitin is safe when compared to other arthritis therapies such as NSAIDS, however, information is limited.
Side Effects
May cause mild stomach pain, nausea, bloating, diarrhea, and constipation.
Interactions
For patients taking warfarin, chondroitin may increase INR levels when taken at doses of 2400mg daily.
No notable changes in INR were documented when taking chondroitin at doses of 800mg daily.
This data was collected during co-administration of glucosamine and chondroitin. The effects of each individual product on INR in patients taking Warfarin have not been studied. Real World Study
The largest double-blind study involving chondroitin was the Glucosamine and Chondroitin Arthritis Intervention Trial published in 2006. Its focus was on patients suffering from osteoarthritis of the knee. Researchers concluded that the supplement provided no additional improvement of symptoms when compared to both placebo and a positive control treatment with an anti-inflammatory medication.
Chondroitin is not an appropriate medication for anyone in need of acute treatment. It is likely best served as a preventative treatment and may have benefits in several areas of the body other than joints, but until more sound research is done it is difficult to reccomend for any indication with confidence. Since it is considered safe, however, I wouldn't discourage anyone interested in investing the time necessary from trying it for themselves. Just remember to talk to your doctor before starting any new medications. ~ A Hess
Professional Conclusion
References
1. 2. 3. 4. Chondroitin. Lexi-Drugs. Lexicomp. Wolters Kluwer Health, Inc. Riverwoods, IL. http:/ /online.lexi.com. Accessed February 23, 2022. Chondroitin Sulfate. Professional Supplement Center. https://www.professionalsupplementcenter.com/ Aisle7.aspx?%2Fassets%2Fnutritional-supplement%2Fchondroitin-sulfate%2Fhow-it-works. Accessed February 23, 2022. Morrison LM, Emick N. Coronary heart disease: reduction of death rate by chondroitin sulfate A. Angiology. 1973;24(5):269-287. doi:10.1177 /000331977302400503. Accessed February 24, 2022. Sawitzke AD, Shi H, Finco MF, et al. The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: a report from the glucosamine/chondroitin arthritis intervention trial. Arthritis Rheum. 2008;58(10):3183-3191. doi:10.1002/art.23973. Accessed February 24, 2022.
