Effectiveness Safety

Not enough studies have been done to prove the safety of goldenseal Women who are pregnant or breastfeeding should avoid this Patients with type 2 diabetes should avoid this Patients on other medications should speak with a provider before starting Infants should not be given goldenseal This Is also contraindicated In hyperbilirubinemia, hypertension, and inflammatory GI conditions

Adverse Side Effects Interactions

Potential side effects include: irritation of the throat/mouth, nausea, increased nervousness, digestive upset, constipation, hallucinations, excitability, and cardiac damage

Main drug interactions include cyclosporine, digoxin, anticoagulants, antiarrhythmics, antipsychotics, metformin, and beta-blockers Many other drugs include potential interactions as well

Article Summary

Berberine is the most bioactive alkaloid component in goldenseal Berberine shows various types of therapeutic effects Research suggests potential therapeutic effects of goldenseal This article examines randomized, doubleblind clinical studies on the efficacy and pharmaceutical activity of this supplement