Barts and the London School of Medicine and Dentistry PG 2011.pdf by Queen Mary University of London

Barts and The London School of Medicine and Dentistry Postgraduate Prospectus Entry 2011

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Contents

Why study at Barts and the London

2 Medicine and Dentistry Graduate School 4 Structure of the School of Medicine and Dentistry 6 Blizard Institute of Cell and Molecular Science 10 Institute of Cancer 38 Institute of Dentistry 52 Institute of Health Sciences Education 76 William Harvey Research Institute 86 Wolfson Institute of Preventive Medicine 108 How to apply 120 Tuition fees 122 Living costs and funding your study 126 International students and English language requirements Campus life and accommodation

Useful Queen Mary websites

Programme index

132 136 139 140

Why study at Barts and The London?

Barts and The London School of Medicine and Dentistry

Why study at Barts and The London?

Welcome Welcome to Barts and The London School of Medicine and Dentistry. It’s a fantastic place to study. We’ve got world experts in their areas of research and particularly in cancer research, in stem cell research, in cardiovascular research and coupled with that, we’re located right in the heart of London. We’ve got two main campuses of the medical school, one’s in Charterhouse Square which is just round the corner from the Barbican. And the other in Whitechapel which is a thriving area of London with so much happening in it. The School offers taught Masters and Postgraduate Diploma programmes in a wide range of areas, including: Surgical Science; Clinical Drug Development; Forensic Medical Sciences; Healthcare Research Methods; Clinical Microbiology; Gastroenterology; Primary Care; Cancer Therapeutics; Molecular Pathology and Genomics; Sports and Exercise Medicine; Clinical Dermatology; Transcultural Mental Healthcare; Dental Public Health; Experimental Oral Pathology; Orthodontics (incorporated in MOrth Training); Paediatric Dentistry; Periodontology and Prosthodontics. The William Harvey Research Institute is home to the distinctive MRes degree in Inflammation: Cellular and Vascular Aspects.

You will find out more about these programmes and others in the pages of this prospectus.

Medicine and Dentistry Graduate School Professor Joy Hinson is the Dean for Postgraduate Studies and is the Director of the Graduate School. She is supported by an Associate Dean for Research Degrees, Dr Paul Allen, and by an Associate Dean for Taught Courses, Dr Martin Carrier. The Dental Institute also has an Associate Dean for Taught Courses, Professor Ray Croucher.

Professor Joy Hinson Chair of Postgraduate Education, Barts and The London School of Medicine and Dentistry

The Graduate School was established in the School of Medicine and Dentistry in order to ensure that students on both postgraduate taught courses and research degrees receive teaching of the highest academic standard and appropriate supervision and pastoral support.

Barts and The London School of Medicine and Dentistry

Why study at Barts and The London?

Barts and The London School of Medicine and Dentistry is a major centre of medical and dental teaching and research in London. Our postgraduates learn from, and work alongside, renowned experts. If you’re keen to build on your existing skills and knowledge, be part of a thriving postgraduate community, and gain a qualification recognised around the world for its quality, then this could be the place for you. Research is at the heart of everything we do at Barts and The London. We have more than 250 research associates or fellows, and an annual budget of approximately £30 million. Our research activities are arranged in academic teams. Therefore, a typical research project might involve undergraduates on project work; intercalated or MSc students; staff supervisors who may be professors or consultants; doctors undertaking postgraduate study; and non-medical basic scientists working for a PhD. In most research centres there are postdoctoral fellows, emeritus staff and international visitors, which generates a lively and enthusiastic atmosphere for vigorous research.

The funds to support medical and dental research come from many sources. These include the HEFCE funds administered by the College, the Charitable Foundation of St Bartholomew’s and the Royal London Hospitals, the Department of Health, industry, and bodies such as the Medical Research Council, the Engineering and Physical Sciences Research Council, the Wellcome Trust and many medical charities.

Our research excellence The 2008 Research Assessment Exercise results showed Barts and The London School joining Oxford, Cambridge, Imperial College and University College London in the top five research-active medical and dental schools in England. The Dental School was ranked 1st equal in the UK (with Manchester). According to rankings published in the Times Higher Education, Barts and The London scored in the top five nationally in: • The Institute of Cancer was ranked 3rd out of 14 submissions in terms of 3* and 4*outputs and joint 5th in the UK overall, ahead of Oxford, Imperial, King’s College London and University College London. • The Blizard Institute of Cell and Molecular Science, returned in Hospital-Based Clinical Subjects, was ranked 1st equal with Cambridge and Edinburgh in terms of 3* and 4* outputs

and was joint 7th overall out of 28, ahead of Manchester, Newcastle and Southampton. • Dentistry was ranked 1st equal with Manchester based on 3* and 4* outputs, and 2nd overall on Grade Point Average out of 14 UK dental schools. The Institute of Health Services Research was ranked 4th overall out of 28 ahead of Oxford, University College London and King’s College London, both overall and by 3* and 4* outputs. • The William Harvey Research Institute, returned in Preclinical and Human Biological Sciences, was ranked 3rd in terms of 3* and 4* outputs, and 4th overall out of 13, ahead of King’s College London, Bristol and Nottingham. • The Wolfson Institute of Preventive Medicine, returned in Epidemiology and Public Health, was 2nd out of 21 in terms of 3* and 4* outputs, and 3rd overall, ahead of Oxford, University College London and Bristol.

Barts and The London School of Medicine and Dentistry

Our outlook Barts and The London was formed in 1995 following the merger of the Medical College of St Bartholomewâ&#x20AC;&#x2122;s Hospital and the London Hospital Medical College, both renowned training institutions with long and distinguished histories. This united the strengths of these institutions and the skills of the staff that are involved in clinical care and internationally acclaimed research. The Schoolâ&#x20AC;&#x2122;s teaching hospitals serve a large area of east London and the wider Thames Gateway, with a high prevalence of diabetes, hypertension, heart disease, tuberculosis and other chronic lung diseases, HIV, oral disease, and cancer. Barts and The London is a major referral centre offering a comprehensive range of speciality services. The Royal London Hospital has its own helipad and deals with major trauma patients flown in from around the country. The Dental School works in tandem with the Dental Teaching Hospital at the Royal London which has modern clinical and laboratory facilities.

Medicine and Dentistry Graduate School

Barts and The London School of Medicine and Dentistry

Medicine and Dentistry Graduate School

The School focuses its research activities around six research institutes. These are: • Blizard Institute of Cell and Molecular Science • Institute of Cancer • Institute of Dentistry • Institute of Health Sciences Education • William Harvey Research Institute • Wolfson Institute of Preventive Medicine Each of the six Institutes has a Director of Graduate Studies who is responsible for the research students in that Institute. You will find out more about current research activity and specialist facilities in each institute section further on in this prospectus.

Postgraduate study opportunities The School has around 800 registered postgraduate students: 400 MPhil/PhD students, 100 MDRes students and 300 postgraduate taught course students. As a research student, you will receive training in transferable skills in accordance with the Research Councils skills/training requirements for research students. Some of this training is delivered by the Education and Staff Development team at Queen Mary and much is provided by the Institutes.

The Graduate School organises a three-day induction programme every autumn term, which includes general research skills such as presentation skills, statistics, ethics, health and safety. This is followed by a welcome party giving the new students an opportunity to meet other postgraduate students, their Institute Graduate Tutor and the student representatives on the Postgraduate Research studentstaff committee.

Taught programmes

Every year, usually in the summer term, each institute hosts a Postgraduate Research day where all research students have the opportunity to present posters and give an oral presentation of their research.

• Cancer Therapeutics, MSc

The Graduate School also organises a Careers Day for research students with invited speakers from academia, the pharmaceutical industry, teaching, publishing, the Civil Service and banking.

• Diabetes, MSc

Postgraduate students in Barts and The London enjoy an excellent social life. Most social activities take place within Institutes. The Graduate School also organises social events, including a summer barbecue on the lawn at Charterhouse Square and a curry night in Whitechapel. These events give research students and postdoctoral researchers an important opportunity to meet researchers from other Institutes across the School.

You can find detailed information on the taught programmes listed below further on in this prospectus.

Medicine • Aesthetic Surgery, PgDip (distance learning) • Analytical Toxicology, MSc / PgDip / PgCert • Burn Care, PgDip (distance learning)

• Clinical Dermatology, PgDip (distance learning) • Clinical Drug Development, MSc / PgDip / PgCert • Clinical Microbiology, MSc

• Endocrinology and Diabetes, MSc / PgDip (distance learning) • Forensic Medical Sciences, MSc / PgDip / PgCert • Gastroenterology, MSc / PgDip • Healthcare Research Methods, MSc / PgDip • Inflammation: Cellular and Vascular Aspects, MRes • PGCert Advanced Mental Health Assessmentt • Mental Health: Transcultural Mental Healthcare, MSc / PgDip • Mental Health: Psychological Therapies, MSc / PgDip

Barts and The London School of Medicine and Dentistry

Medicine and Dentistry Graduate School

• Molecular Pathology and Genomics, MSc • Non-Invasive Aesthetic Techniques, PgCert (distance learning) • Operative Gynaecology and Minimally Invasive Skills, MSc / PgDip • Operative Orthopaedic and Arthroscopic Skills, MSc / PgDip • Primary Care, MSc / PgDip • Public Health, MSc / PgDip • Sport and Exercise Medicine, MSc / PgDip • Surgical Skills and Sciences, MSc • Translational Neuroscience, MSc / PgDip / PgCert

Dentistry • Dental Clinical Sciences, PgDip • Dental Implantology, MClinDent • Dental Public Health, MSc • Dental Technology, MSc / PgDip / GradCert • Experimental Oral Pathology (Oral Sciences), MSc • Implant Dentistry, MSc • Oral Biology, MSc • Oral Medicine, MSc • Oral Surgery, MClinDent • Orthodontics, MSc • Paediatric Dentistry, MClinDent • Periodontology, MClinDent • Prosthodontics, MClinDent

Research degrees There are research opportunities within each of the Institutes and you can find more information on key research areas within each Institute and the research interests of senior staff within each Centre in the following sections. The School offers the following research degrees within the various institutes: PhD Minimum period of registration for a Doctor of Philosophy is two years full-time or four years parttime. Applicants must hold a minimum of an upper second class honours degree or overseas equivalent. MD(Res) Minimum period of registration for a Doctor of Medicine is two years full-time or three years part-time. Applicants must have full or limited registration with the General Medical Council of the United Kingdom. MPhil Minimum period of registration for a Master of Philosophy is two years full-time or three years parttime. Applicants must hold a minimum of an upper second class honours degree or overseas equivalent.

Career opportunities Barts and The London provides a unique postgraduate learning atmosphere for both clinicians and basic scientists. Our Masters level programmes provide opportunities for experienced clinicians to develop specific skills as well as for more junior clinicians who wish to develop their particular specialties to enhance their chosen career paths. Other Masters programmes provide opportunities in areas ranging from cancer therapeutics to inflammatory disease. In many cases this allows students to gain invaluable expertise for professional development, in a wide variety of workplace settings, such as government laboratories, pharmaceutical companies and universities. Our extensive PhD programme is widely regarded as an ideal environment within which to acquire key research skills. We also put a strong emphasis on other transferable skills which are essential to equip students for a successful career after their degree.

Barts and The London School of Medicine and Dentistry

Trust Hospitals). These are doctors who will go on to specialist training posts, take up consultant and clinical academic positions, whilst continuing with clinical-based research activities. You will find a number of graduate profiles in this prospectus alongside the detailed programme descriptions in each institute section.

Our PhD students are therefore sought after and highly employable, not only in a research setting (private and public sector), but also in related career paths where a PhD is an important asset; notably, scientific publishing, patenting, education, civil service, regulatory bodies, and technological and product specialities. Our ex-students will also be found in careers in banking and market research and some have established companies of their own. We are also involved in the training of clinicians who study for a PhD or an MD(Res) (often together with our associated NHS

Further information Please contact: Admissions and Recruitment Office Tel: +44 (0)20 7882 5533 Fax: +44 (0)20 7882 5588 email: pgsmd@qmul.ac.uk A full list of the staff of the School is available from: www.smd.qmul.ac.uk

Blizard Institute of Cell and Molecular Science

Barts and The London School of Medicine and Dentistry

Blizard Institute of Cell and Molecular Science www.icms.qmul.ac.uk

Institute Director Professor Mike Curtis email: m.a.curtis@qmul.ac.uk

Director of Graduate Studies Dr Paul Allen email: p.d.allen@qmul.ac.uk

neuroimmunology, neural stem cells, neuro-oncology and trauma research; Paediatrics including bone marrow failure research, Down’s syndrome research and childhood respiratory function.

• Digestive Diseases

The Blizard Institute of Cell and Molecular Science is the largest Institute of the School of Medicine and Dentistry and is based in the award winning Blizard Building on the Whitechapel campus. The aims of the Institute are:

• Immunology and Infectious Disease

• Creation of an environment for world class biomedical research

• Neuroscience and Trauma

• Development of innovative, interdisciplinary and cutting edge programmes of research

The BICMS is composed of six Centres and one Group: • Cutaneous Research • Diabetes

• Paediatrics • Pathology Group

Key research areas Cross cutting research themes in genomic medicine, stem cells and regenerative medicine; Cutaneous research including epithelial stem cell biology, the genetics of skin disease and skin cancer; Diabetes including genetic susceptibility to diabetes, insulin biology and cell signalling; Digestive diseases including human nutrition, the genetics of gastrointestinal disease, neuro-gastroenterology, hepatology, gastrointestinal surgery, colorectal cancer genetics; Immunology and Infectious Disease including T-cell biology, mucosal immunology, TB, HIV and oral pathogens; and haematological malignancies; Neuroscience and Trauma including mechanisms of neuroprotection and neuroregeneration,

• Provision of the intellectual environment and physical facilities for high quality training • Development of partnerships with neighbouring NHS Trusts and local communities in east London to build research collaborations which address the health needs of our local population. The Centres are closely allied to the large clinical departments within Barts and The London NHS Trust and the priorities of the local Primary Care Trusts.

We aim to build a pipeline of activity from basic science, clinical research and translational medicine to develop improved methods of diagnosis, management and therapy of disease with particular relevance to the clinical activity of Barts and The London NHS Trust and to the benefit of our local population in east London. The geographic location of the BICMS and its close liaison with primary care and NHS Trusts provides an excellent opportunity for the development of translational medical research. Clinical academics in the BICMS are championing these links with the recently awarded NE London Diabetes Local Research Network (LRN), Medicines for Children LRN (joint with GOSH), a hub of the Thames Stroke LRN, a spoke of the North Thames Dementia and Neurodegenerative Diseases LRN, and the relocation of the HPA Mycobacterial Reference Unit from King’s College London.

Barts and The London School of Medicine and Dentistry

Blizard Institute of Cell and Molecular Science

All BICMS Centres and Groups are housed in the Blizard Building, a £44 million purpose-built development in Whitechapel. This unique, award winning, research building provides state-of-the-art laboratory accommodation based on an innovative open plan design for 400 staff and postgraduate students. The laboratory facilities are located on a single laboratory floor of approximately 3,500 m2, the design of which aims to encourage maximal interaction between different research groups and cost efficient usage of core equipment and facilities. The BICMS has also benefited from £4 million investment from Queen Mary for equipment which has enabled the establishment of core facilities in Genomics (jointly with the Genome Centre at Charterhouse Square) Flow Cytometry, Imaging, Transgenics and a global siRNA screening facility all of which are equipped to a high standard with the latest technology.

In UoA10, 75 per cent of our research activity was rated 4*/3* which placed the School first equal (with Manchester) out of 14 returns from UK Dental Schools.

Staff of the Institute were returned under two Units of Assessment: UoA4 (Other Hospital based subjects) and UoA10 (Dentistry).

• Postgraduate Diploma in Aesthetic Surgery

Over 60 staff were returned in UoA4 and 80 per cent of our research activity in this return was judged to be 4*/3*. In terms of national rankings, this placed the Institute first equal (with Cambridge) out of a total of 28 submissions.

The annual research income of the Institute in 2008/9 was in excess of £13 million and major research funders include the Medical Research Council, the Biotechnology and Biological Sciences Research Council, the Wellcome Trust, Cancer Research UK and the Leukaemia Research Fund. Research findings from the Institute are frequently reported in the national media, including the discovery of the genetic causes of skin disease and diabetes. Postgraduate programmes are an important element of the academic activity of the BICMS and we currently offer: • Postgraduate Certificate in NonInvasive Aesthetic Techniques

• Postgraduate Diploma in Burn Care • Postgraduate Diploma in Clinical Dermatology

These programmes have developed in response to the research teaching and training needs of individuals pursuing careers in disciplines encompassed by the Institute. Each programme has a unique structure designed to best meet these needs. The Blizard Building also houses a bioscience education centre, the Centre of the Cell, which aims to engage young people and schools in the principles of scientific and biomedical research and the background to many of the major scientific and ethical issues facing young people, educationally and socially. The practical work being done by researchers in the BICMS and elsewhere in the Medical and Dental School is showcased in this unique educational facility.

Centre for Cutaneous Research The Centre for Cutaneous Research is one of the largest academic dermatology groups in Europe. Research within the Centre is currently organised into distinct programmes, which bring together a critical mass of clinical and non-clinical researchers under the current themes: • Cancer biology

• MSc/Postgraduate Diploma in Clinical Microbiology

• Genetics

• MSc in Diabetes

• Epithelial differentiation and barrier formation

• MSc/Postgraduate Diploma in Gastroenterology • MSc/Postgraduate Diploma in Translational Neuroscience

• Stem cells

• Burns and wound repair

Barts and The London School of Medicine and Dentistry

Major achievements within the Centre include: • Mechanistic evidence for the carcinogenicity of the immunosuppressive azathioprine in skin, revealing a therapy-related cancer risk. • Evidence for human papillomavirus (HPV) modulation of AKT signalling, and a possible role for AKT2 in squamous cell carcinoma (SCC). • The genetic and molecular mechanisms underlying basal cell carcinoma (BCC). • That Axl is a novel marker of squamous cell carcinoma. • ABCA12 as the gene for the severe congenital skin disease Harlequin Ichthyosis resulting in the development of rapid prenatal screening for affected families. • RSPO4 as the gene for anonychia, therefore a key role for the Wnt pathway in nail development. • Translational research into identification of novel new polymers to support tissue engineered skin and characterisation of survival characteristics of engineered skin on patients.

• A signalling role for cadherins of the epidermal desomosome and the role of AKT signalling and its downstream pathway in skin barrier formation. • The first description of a non gap-junction functional role for connexin 31.

Centre for Diabetes The Centre has a major interest in genetic susceptibility to diabetes and related disorders. Barts and The London is at the forefront of the international gene discovery programs in these disorders (including genome-wide association scans, candidate genes, functional genomics and prevention strategies). In addition, the Centre has an ongoing programme of research into epigenetic influences on diabetes development. Clinical research is underpinned by: DOH funded NE London Diabetes Local Research Network; prevention initiatives in type 1 diabetes; LADA; type 2 diabetes (T2D) focusing on the local Bangladeshi population. Current research is focused in the following areas: • Genetics and diabetes • Insulin action and secretion in metabolic and cardiovascular disease

• Development of a Burns network.

• Inositide signalling

• Promotion of cell migration by hypoxia via metalloproteinase-9 and phosphorylation of focal adhesion kinase in keratinocyte migration on matrix.

Major achievements within the Centre include:

• Stem cells

• Discovery of novel genes associated with T2D using a

genome wide association scan and the first evidence of gene to gene interaction increasing susceptibility to disease. • A landmark study (CARDS) demonstrating the feasibility of primary prevention of cardiovascular disease in T2D using a statin. • Establishing the role of the pyruvate dehydrogenase kinases in the control of the function in insulin-sensitive tissues and in pancreatic beta cells. • Identification of a novel signaling pathway important for insulin action in muscles and adipocytes • Identification of the critical role of the enzyme phospholipase C gamma1 in metastasis development.

Centre for Digestive Diseases The newly formed Centre for Digestive Diseases undertakes research and teaching into all aspect of the gastrointestinal tract, liver and nutrition. The Centre was established in 2009 and brings together the former Centres for Gastroenterology and Academic Surgery. In so doing the Centre is directly aligned to the Digestive Diseases Clinical Academic Unit (CAU) at Barts and The London NHS Trust. The Centre is one of the very few units that undertakes research in both paediatric and adult disease. It is organised as a research community with principal investigators grouped into major

Barts and The London School of Medicine and Dentistry

Blizard Institute of Cell and Molecular Science

interdisciplinary research groups encompassing: epithelial cell biology; infection, immunity and inflammation; hepatology; neurogastroenterology; ano-rectal physiology; colorectal cancer and colorectal surgical development

Centre for Immunology and Infectious Disease The Centre includes research groups investigating cutting-edge topics in microbiology, virology and immunology. Full details can be found on our website http://www.icms.qmul.ac.uk/centr es/immunologyandinfectiousdisea se/index.html.

The Gastrointestinal Physiology Unit, an integral part of the Centre and national referral centre, develops new investigations of colorectal function. Reconstructive surgery is conducted in the Colorectal Development Unit, established in 1997 with NSCAG funding. There is a longstanding tradition of research in neurogastroenterology within the Centre, established by Professor David Wingate in the 1970s. This group is housed in a purpose built facility, the Wingate Institute and is closely linked with the neurogastroenterology interests of the Academic Centre of Surgery. Major achievements within the Centre include: • Establishing the field of nutrition and gene regulation in the intestine, particularly epigenetic regulation • Identification that the chromosomal region harbouring IL1 and IL21 underlies the susceptibility to coeliac disease using a genome wide association scan • Elucidating the mechanism by which Dengue and Hepatitis viruses inhibit interferon signalling

• Discovering the central importance of interferongamma in the intestine resistance to infection with Cryptosporidium • Developing a new vaccine platform to immunize against viruses • Cerebral imaging of visceral pain; and elucidation of pain neuronal pathways from the upper GI tract in order to identify new therapeutic targets. The Centre also teaches gastroenterology, hepatology and nutrition to undergraduates. Postgraduate teaching is undertaken in the MSc Programme in Gastroenterology.

Investigators in the centre receive blue-chip funding from MRC, Wellcome Trust, BBSRC and EUFP7, and publish in top journals. At mucosal surfaces such as the mouth and the gut there is intimate association between the immune system, food antigens, and the resident commensal bacteria. Several groups are investigating how this relationship is regulated in health, what goes wrong in inflammatory diseases such as Crohn’s disease and periodontitis, and how the immune system distinguishes between pathogens and the normal microbiota. Studies include understanding mucosal T cell biology in health and disease, how dendritic cells modulate Tcell activity, the development of unconventional T-cells, and analysis of bacterial surface macromolecules. People who settle in east London come from many parts of the world, where TB (Mycobacterium tuberculosis) and AIDS (HIV) are endemic. We investigate pathogenic mechanisms, new drug targets, and strategies for improved disease prevention in both of these globally important

Barts and The London School of Medicine and Dentistry

infections. We host the Health Protection Agency National Mycobacterium Reference Unit which contributes to the Centre’s research strength on this topic. We also investigate epidemiology and pathogenic mechanisms of other organisms including varicella zoster virus, Pseudomonas aeruginosa, and Streptococcus pneumoniae. Resistance to antibiotics and antiviral agents presents a major challenge to modern medicine. We study the molecular and genetic mechanisms of resistance to antimicrobials, how resistance spreads, and novel strategies for combating resistance. Particular strengths are in drug resistant HIV and multiply antibiotic resistant gram negative bacteria.

Centre for Neuroscience and Trauma The Centre has eighteen academic staff and research is focused on three interrelated topics: Trauma; Neuroinflammation and pain; Neuro-oncology and genomics. Trauma The focus is on spinal cord and peripheral nerve injury and coagulation. The group has identified several therapeutic strategies to prevent complications of injury, and to limit and repair its damage.

Neuroinflammation and pain The main disease focus of the Neuroimmunology group is multiple sclerosis. £5 million of grants is being used will be used to research immune tolerance strategies, develop neuroprotective and neurorestorative therapies for progressive multiple sclerosis and manipulate cannabinoid biology as a therapeutic strategy to improve the symptoms of multiple sclerosis. Neuro-oncology and genomics Research includes: • A molecular and developmental biology approach in mouse models which shows how cellular and molecular mechanisms control the development of the central nervous system and can contribute to brain tumorigenesis when deregulated.

• A study of the function of human chromosomes and the genetic basis of cancer, with the discovery of distinct higher order chromatin configurations and loop domains that are dependent on gene density and transcriptional activity. Research also focuses on critical pathways involved in tumorigenesis, with an emphasis on brain tumours. There are also active research programmes in motor neurone disease, pain, muscle regeneration, biomarkers and clinical outcomes. Future objectives for the Centre include the establishment of research and clinical units in spinal injury and neuroinfectious diseases and further development of basic research in CNS tumour biology.

Barts and The London School of Medicine and Dentistry

Blizard Institute of Cell and Molecular Science

Centre for Paediatrics The Centre for Paediatrics facilitates paediatrics research, as well as Child Health teaching on the MB BS programme. We work closely with the paediatric clinical services provided by Barts and The London (BLT), the second largest paediatric services in London (Barts and The London Children’s Hospital). The Centre regularly publishes scientific findings in journals including, Nature, Nature Genetics, New England Journal of Medicine and The Lancet. Research in Paediatrics is organised into the following themes: Haematology The principal research interest is bone marrow failure focusing on the pathophysiology of the inherited bone marrow failure syndromes, particularly dyskeratosis congenita (DC). Studies are also being undertaken on other haematological disorders including: the pathophysiology of myelodysplasia/ leukaemia and the establishment of a clinical network for sickle cell disease in east London. Neonatal Medicine A major initiative within Neonatal Medicine relates to investigation of the associations between low birth weight and airway function and the underlying mechanisms. Other areas of research include:

• The use of Doppler ultrasound in the investigation of the neonatal circulation • The mechanisms and control of placental transport of nutrients from mother to foetus. Respiratory and Environmental Medicine Main research interests are paediatric asthma, and the impact of environmental pollutants on the developing lung. An environmental research group is studying the cellular and molecular mechanisms underlying the increased vulnerability to pneumococcal pneumonia in children exposed to particulate air pollution. Down’s syndrome Professor Nizetic utilises a functional genomics approach to the study of effects of gene dose in human aneuploidy with an emphasis on Down’s syndrome as a model. In particular, gene dose effects of trisomy of human chromosome 21 on embryonic stem cell differentiation and cell fate, and myeloid stem cell lineages in relation to childhood leukaemia in Down’s syndrome are under investigation. The work involves gene expression arrays, proteomics and potentially ZF transgenic modelling.

Pathology Group The focus of this group is the exploration of cellular pathogenesis. Members are experts in the morphological aspects of disease, gene and protein expression in health and in disordered function eg cancer, inflammation and trauma. Members of the group play a large and important role in the ongoing teaching programmes across the medical and dental schools, and play an integral role in the research of groups in Pathology as well as other centres. Major links exist with groups working in gastroenterology, cancer, neurosciences, cutaneous and child health. The Academic Haematology Unit has developed from a broad clinical base and particular areas of clinical excellence including haematological malignancies and autoimmune thrombocytopenia (ATP). The ATP research has led to the development of particular expertise in flow cytometry under Professor Marion Macey and a cross Centre interest in autoimmune disorders. Other research interests lie in gene therapy for haemophilia, molecular pathology of von Willebrands disease, the link between cancer and thrombosis and the mechanisms of inhibitor development in haemophilia A.

Barts and The London School of Medicine and Dentistry

Senior staff research interests Blizard Institute of Cell and Molecular Science

Malcolm Alison PhD(Newcastle) DSc(Newcastle) FRCPath(Lond) Professor of Stem Cell Biology, Centre Lead for Diabetes Professor Alisonâ&#x20AC;&#x2122;s research focuses on stem cell biology in human pancreas, liver and gut in both health and disease, specifically fibrosis and cancer. Through searching for cells deficient in mtDNA-encoded cytochrome c oxidase (COX), we can map the movement of cells through tissues, and can establish the monoclonality of COX-deficient patches by whole mtDNA sequencing of laser-captured cells. The technique allows us to infer the location of the stem cell niche. Using human pancreatic cancer cell lines, we are studying the clonogenicity of specific subpopulations such as the SP and ALDHbright fractions, and exploring the roles of trefoil peptides in tumour progression. The group is also studying the role of bone marrow-derived cells (BMDCs) in pancreatic and gut disease, specifically the contribution of BMDCs to chronic pancreatitis in animal models with cerulein treatment and an IL-10 KO background.

Qasim Aziz PhD FRCP Professor of Neurogastroenterology Professor Azizâ&#x20AC;&#x2122;s major research interest is to study the mechanisms of visceral pain in health and disease. His work has contributed to the current understanding of the brain neural network involved in processing human visceral pain using functional brain imaging techniques and has demonstrated

the role of psychological factors in modulating this network. He has studied the role of inflammation / injury in sensitising visceral nerves leading to pain and is currently studying psycho-physiological factors causing inter-individual variability in pain perception in health and patients with Functional Gastrointestinal Disorders. Other research interests include the neurophysiological mechanisms of nausea and the link between Joint Hypermobility Syndrome and gastrointestinal symptoms.

David Baker BSc PhD Professor of Neuroimmunology Professor Bakerâ&#x20AC;&#x2122;s research interests have focused on experimental delay hypersensitivities most notably in the brain where his research has focused on understanding and controlling established immune responses. Aspects of immunological tolerance induction in the skin initiated during PhD studies were adapted for studies for the control of autoimmunity of the central nervous system and are being developed for the control of immunity in multiple sclerosis. This follows on from the development and characterisation of novel models of multiple sclerosis. His research has spanned many areas of immunobiology including, immunopathology, cytokine biology, blood brain barrier dysfunction; myelin autoantigens, genetic mapping of disease, gene therapy and immunological tolerance induction in established immune responses. Most recently he has been involved in

understanding the involvement of the cannabinoid system in symptom control, neurodegeneration and immunity as they relate to multiple sclerosis, as well as the development of agents for the treatment of chronic neurogeneration and symptom control.

David Beach PhD FRS Professor of Stem Cell Biology Professor Beach's research is focused on the molecular pathways that regulate the proliferation and fate determination of human and other mammalian cells in particular, the mechanisms of cell cycle control and cellular senescence. Further areas of investigation concern the genetic mechanisms by which normally proliferating cells become oncogenically transformed when the regulation of pathways affecting cellular senescence, anchorage dependence, motility and angiogenic activation become altered. His group is also interested in the biology of stem cells: by studying the unusual cell cycle regulatory mechanisms of both embryonic and adult stem cells, they will gain an understanding of how growth potential becomes restricted during normal development and will define the role of adult stems cells in the development and maintenance of tissues and organs.

Karim Brohi FRCS FRCA Professor of Trauma Sciences Karim Brohi is the lead for research for the Trauma Clinical Academic Unit at Barts and The

Barts and The London School of Medicine and Dentistry

Senior staff research interests Blizard Institute of Cell and Molecular Science

London NHS Trust. Research within the Trauma Group covers the breadth of the trauma sciences, from injury prevention and public health, the effects of trauma and the body’s responses to injury and through all stages of management through to rehabilitation. A strong focus of the research has been the identification and characterisation of Acute Traumatic Coagulopathy, and the development of experimental models to explore new diagnostic tools and therapeutic interventions. We received £2 million funding from the National Institute of Health Research to continue our research in the field of trauma coagulopathy and massive transfusion in conjunction with the National Blood Service. Along with other academic partners, the group is also developing a systems biology model to haemostasis.

Stephen Bustin BA PhD(TCD) Professor of Molecular Science Professor Bustin's main research interests focus around three research themes: the role of dietary, hormonal and growth factors in colorectal cancer tumorigenesis, development of molecular diagnostic assays for the detection of nosocomial infections and the standardisation of real-time PCR technology for nucleic acid quantification. Most recently his group has investigated a newly identified molecular mechanism underlying the protective effects of vitamin D

and led the international efforts to implement the Minimum Information for Publication of Quantitative Real-Time PCR Experiments (MIQE) guidelines. Professor Bustin has written and edited two books on PCR, published the most-cited review article on this topic (approaching 1,600 citations) and is playing a central role in defining the use of this technology as a clinical diagnostic tool.

Carolyn Byrne BSc PhD(Sydney) Professor of Skin Biology Professor Byrne is interested in how the skin barrier prevents microbial assault and ultraviolet damage. The skin barrier resides in both the epidermal stratum corneum and the underlying adhesion complexes. Professor Byrne’s group is interested in the regulation of epidermal keratinocyte differentiation and skin barrier formation during fetal development, and the role and regulation of specific classes of skin barrier proteins (LCE proteins) that are differentially expressed and responsive to ultraviolet B. The group has lately focused on the PI-3kinase-AKT pathway with the proposal that it pleiotropically regulates skin barrier formation. The group has shown that this pathway is a target of environmental influences such as viral infection and ultraviolet radiation causing barrier compromise. AKT kinases are also differentially altered during skin carcinogenesis and with clinical collaborators we are investigating the role this pathway plays in skin tumour progression.

Kathleen Costeloe MB BCHir FRCP FRCPCH Professor of Paediatrics A major initiative within Neonatal Medicine relates to investigation of the associations between low birth weight and airway function and the underlying mechanisms. This has necessitated long term collaborative studies involving neonatologists from Barts and The London (Professor Costeloe, Dr Husain and Dr Kempley) and from other institutes (Professor Dezateux and Professor Stocks). Important contributions include the documentation of outcome in very premature infants in the UK and how this is changing with modern interventions.

Nick Croft MB BS(Lond) PhD(Edin) DCH(Glas) MRCP FRCPCH Reader in Clinical Paediatric Gastroenterology Dr Croft’s research interests are based around clinical and translational research focusing on paediatric gastroenterological diseases such as inflammatory bowel disease, coeliac disease, food allergy, gastro-oesophageal reflux and gastrointestinal infections. This has recently included examining the underlying genetics of growth failure in IBD, the growth response to enteral nutrition in children and the phenotype of IBD in children and adults. He is a co-director of the London and south east medicines for children local research network which supports the development and running of trials of treatments in children. He is also the co-Chair of the UK Paediatric

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Gastroenterology, Hepatology and Nutrition Clinical Studies Committee. Dr Croft’s main teaching role lies in organising the MSc and Diploma in Gastroenterology which supports research through projects run as part of the taught programme, as well as attracting quality students to study for higher degrees. As a member of the Human Development Systems planning unit he is a member of the undergraduate paediatric teaching team.

Mike Curtis BSc(Bris) PhD(Lond) Professor of Microbiology, Director of Blizard Institute of Cell and Molecular Science Professor Curtis’s current research is focused in two main areas. First, the cell surface polysaccharides, lipopolysaccharides and proteolytic enzymes of Porphyromonas gingivalis, one of the key pathogens in periodontal disease, are key virulence determinants and play important roles in both the persistence of this bacterium in chronic disease and its interaction with the immune and inflammatory systems of the host. In MRC funded studies, we are using biochemical and classical genetics approaches to determine the structure and biosynthetic pathways of these macromolecules. The second area of research, funded through the NIH, aims to determine the role of the commensal bacteria in the development of the innate immune response and maintenance of health in the oral tissues. These studies involve comparative molecular analysis of

periodontal tissues from germ free versus conventionally reared mice and examination of the influence of individual bacterial species on the expression of markers of health.

Inderjeet Dokal MBChB MD FRCP FRCPCH FRCPath Chair in Child Health, Centre Lead for Paediatrics Professor Dokal’s main research interest is the pathophysiology of aplastic anaemia/bone marrow failure. In order to understand the biology of aplastic anaemia (AA) he has focused on monogenic disorders associated with AA. This includes Dyskeratosis Congenita (DC) and Fanconi Anaemia (FA). He has had a close collaboration with his colleague Dr Tom Vulliamy (Senior Lecturer in Molecular Biology) since 1995. They have elucidated the genetic basis of several subtypes of DC. They have also demonstrated a link between DC and AA and that this group of disorders arise from defects in the enzyme telomerase. The main focus of current research is to establish the

pathophysiology of the many uncharacterised cases of DC and AA. Studies are also being undertaken to explore the possibility of correction of telomere length in-vitro as this may represent a new therapeutic approach for DC/AA patients failing conventional therapies. The group also has a clinical and research interest in other genetic disorders associated with bone marrow failure/myelodysplasia/leukaemia.

Paola Domizio BSc MB BS FRCPath Professor of Pathology Education, Teaching Lead, Blizard Institute of Cell and Molecular Science Professor Domizio is Professor of Pathology Education and Honorary Consultant in Histopathology. Her major fields of interest are medical education and gastrointestinal pathology, in which she has a national reputation. For many years she has been Director of Pathology teaching at Barts and The London, but also has a wider role in curriculum development and

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Senior staff research interests Blizard Institute of Cell and Molecular Science

management and running examinations. Professor Domizio is currently Lead Teacher for the Blizard Institute of Cell and Molecular Science. She is an external examiner for several universities and also examines for the Royal College of Pathologists and the Royal College of Surgeons. She has also held several positions of responsibility in relation to postgraduate education, including educational supervisor and regional adviser in postgraduate education.

Sina Dorudi BSc MB BS PhD FRCS FRCS(Gen) Professor of Surgical Oncology Professor Dorudiâ&#x20AC;&#x2122;s clinical research interests are in surgical training, pelvic cancer surgery and inflammatory bowel disease. His research interests centre around detailed prognostic stratification of colorectal cancer patients using microarray technology and the investigation of host-immune responses in colorectal cancers. His research has focused on the use and development of high throughput assays to distinguish between the well-delineated colorectal cancer phenotypes. A key aim of this research programme is to stratify patients with colorectal cancer by their identified developmental pathway for more accurate prognosis and to identify patients with chemo-resistant disease for the purposes of tailored therapy. His postgraduate education interests have centred on the development of multimedia simulation platforms for training in operative colorectal surgery.

Francis Drobniewski MA(Dub) MSc MB BS(Lond) PhD(Cantab) DTM and H FRCPath Professor of Tuberculosis and Mycobacterial Diseases, Director of the Health Protection Agency National Mycobacterium Reference Unit (MRU), Consultant Microbiologist and TB Physician The research interests of the Clinical TB and HIV Group and the UK Health Protection Agency (HPA) National Mycobacterium Reference Unit (MRU) relate to all aspects of tuberculosis, international public health, AIDS and opportunistic infections. Specifically the group focuses on the diagnosis, and molecular epidemiology of tuberculosis and other mycobacteria, the understanding drug resistance and disease tropisms, hostpathogen interactions and the interplay between TB and HIV

and broader public health problems posed by these diseases both in the UK and overseas. Staff also work outside the laboratory on collaborative international laboratory and public health topics relating to TB and HIV in Russia and Ukraine currently and in partnership with several countries in Africa. We have an international group with one-third coming from overseas and main research collaborations with groups in the UK, USA, Russian, Italy, Germany, Sweden, Malawi, Zambia, South Africa, Argentina.

Marco Falasca Professor of Molecular Pharmacology Professor Marco Falasca works with the Inositide Signalling Group focusing on the role of phosphoinositides and their regulatory enzymes in human diseases such as diabetes and

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cancer. Phosphoinositides comprise a family of eight membrane lipids which play important roles in many signal transducing pathways in the cell. Indeed, phosphoinositides are sources of the second messengers, diacylglycerol, inositol(1,4,5) trisphosphate and phosphatidylinositol (3,4,5) trisphosphate. Signaling through various phosphoinositides has been shown to mediate cell growth and proliferation, apoptosis, cytoskeletal changes, insulin action and vesicle trafficking. A number of advances in signal transduction in the last decade have resulted in the discovery of a growing list of proteins which directly interact with high affinity and specificity with distinct phosphoinositides. These interactions occur through specific phosphoinositide binding domains such as the pleckstrin homology domain. Research projects are particularly focused on the signaling pathways activated by phosphoinositide 3kinase, phospholipase C and lysophospholipids.

Graham Foster BA(Oxon) MRCP FRCP PhD Professor of Hepatology Professor Foster has research interests in the clinical and scientific aspects of chronic viral hepatitis, which is the major focus of the Liver Unit at Queen Mary. Clinical research programs include an assessment of the disease burden in ethnic minority groups - the unit is co-ordinating a Department of Health funded study looking at the prevalence of viral hepatitis throughout the UK.

The Liver Unit has a very active clinical trials program and clinical research projects include studies of novel antiviral agents for the management of chronic hepatitis C are in progress as well as studies evaluating the factors responsible for changes in the rate of fibrosis progression in patients with chronic hepatitis C. The Liver Unit runs a successful laboratory research program studying novel replication systems for the hepatitis C virus and the immune response to viral hepatitis infections. Studies to identify host and viral factors that determine the response to therapy with chronic hepatitis B and chronic hepatitis C are in progress.

Gavin Giovannoni MBBCh PhD FCP(Neurol) FRCP FRCPath Professor of Neurology, Centre Lead for Neuroscience and Trauma Professor Giovannoniâ&#x20AC;&#x2122;s research and clinical interests include Multiple Sclerosis (MS) and other inflammatory disorders of the

central nervous system. Professor Giovannoni runs a MS clinical trials unit and is the principal investigator on several phase II and III MS trials. Other interests include biomarker discovery, for studying the pathogenesis of MS and to establish predictive testing. Professor Giovannoni believes the latter will become increasingly important in the future to identify patients most likely to respond to disease-modifying therapies, to select patients for clinical trials and to assess individualâ&#x20AC;&#x2122;s response to treatment. He is particularly interested in issues that relate to optimising MS disease modifying therapies and particularly the impact and immunology of neutralising antiinterferon beta antibodies. He runs a specialist clinical neuroinflammatory service and a research group investigating both basic science and clinical aspects of MS. Other research interests include antibody mediated autoimmune disorders of the central nervous system.

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Senior staff research interests Blizard Institute of Cell and Molecular Science

Stephen Greenwald BA(Oxon) PhD(Lond) Professor of Cardiovascular Mechanics Professor Greenwald’s research interests include a search for mechanical factors in the genesis of arterial disease, with emphasis on the role of fatigue failure in arterial elastin, foetal programming of essential hypertension and wave propagation in arteries. The link between the elastic properties of arteries, pulse pressure and the mechanical load on the heart is now thought to be the explanation, at least in part, for the widely recognised association between raised vascular stiffness and increased risk of cardiovascular morbidity and mortality. On the applied side, Professor Greenwald’s interest in arterial mechanical properties has lead to studies evaluating the efficacy compliant intravascular stents and the development of a novel optical method for the non-invasive measurement of arterial compliance. The possibility of applying similar optical techniques to the measurement of cardiac output and the assessment of endothelial function is now under active investigation.

Jonathan Grigg BSc MB BS MD MRCP FRCPCH Professor of Paediatric Respiratory and Environmental Medicine Professor Grigg's research interests are paediatric asthma, and the impact of environmental pollutants on the developing lung. Drawing on a new method of assessing individual exposure of children to air pollution, his

environmental research group are studying the cellular and molecular mechanisms underlying the increased vulnerability to pneumococcal pneumonia in children exposed to particulate air pollution. His clinical research group, in close liaison with the NHS service, is developing new therapies targeted at airway inflammation in asthma and cystic fibrosis.

Lucinda Hall BA(York) MSc(Lond) PhD(Glas) Reader in Molecular Microbiology, Centre Lead for Immunology and Infectious Disease Lucinda Hall’s research group is exploring the genetic and evolutionary mechanisms by which bacteria respond to medical interventions such as the widespread use of antibiotics. Previous work has included the description of mechanisms of antibiotic resistance and investigation of bacterial population structure, as well as collaborative work with MA Curtis on a virulence factor in the periodontal pathogen Porphyromonas gingivalis. The group’s current projects involve mutational mechanisms and genome rearrangements in Streptococcus pneumoniae, and the factors mediating the persistence of sulphonamide resistance in Escherichia coli despite dramatically reduced prescribing. The group is also investigating the response of the gut microbiota to treatment of Crohn’s disease by enteral feeding, in collaboration with colleagues in the Centre for Gastroenterology. This forms part

of a developing strategy within CID to understand the interactions between microbiota and the host immune system.

Graham Hitman MB BS MD FRCP(Lond) Professor of Molecular Medicine and Diabetes, Deputy (Research) Head Blizard Institute of Cell and Molecular Science, Clinical Lead of the North East London Diabetes Local Research Network Professor Hitman’s main interests are directed to gene discovery arising from genome-wide association scans in type 2 diabetes and the use of epigenetics to study the gene environmental interaction. He is also one of the principal investigators of the CARDS (Collaborative Atorvastatin Diabetes Study) trial that has influenced the development of current lipid lowering guidelines in diabetes and is a principal investigator of two pilot diabetes prevention trials one of which is an RCT of vitamin D supplementation. He has almost 200 peer reviewed publications and is currently Editor-in-Chief of Diabetic Medicine.

Virginia Hubbard MB BS MSc(MedEd) MRCP Programme Director for Postgraduate Diploma in Clinical Dermatology (International Programme), Honorary Consultant Dermatologist at Homerton University Hospital NHS Foundation Trust Dr Hubbard’s academic interest is Medical Education, with a particular focus on E-learning. She is programme director for the

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Postgraduate Diploma in Clinical Dermatology (International Programme), and is actively involved in the education of undergraduates and chairs an Elearning group within the Medical School.

Teaching Days with patient cases and interactive tutoring. Research interests include the use of digital imaging in patient triage and diagnosis and the wider applications of teledermatology.

David Kelsell BSc PhD Victoria ML Jolliffe MA(Cantab) MRCP FRCS(Ed) MRCGP ARCM Director of Postgraduate Diploma in Clinical Dermatology, Honorary Consultant Dermatologist and Clinical Senior Lecturer, Centre for Cutaneous Research Dr Jolliffe is a clinical academic who is Programme Director for the Postgraduate Diploma in Clinical Dermatology for UK students. In collaboration with Dr Virginia Hubbard, she has developed the diploma into a web-based blended learning programme encompassing E-learning via webCT, clinical DVDs and Clinical

Professor of Human Molecular Genetics Professor Kelsell's main research focus is the identification of the genetic and molecular mechanisms underlying epidermal disease. His PhD involved genetic studies to identify the two breast cancer genes, BRCA1 and BRCA2 and their importance in familial and sporadic breast cancer. Publications include a landmark paper in Nature, identifying Cx26 mutations associated with non-syndromic hearing loss, leading to the discovery that Cx26 mutations

are the major cause of genetic hearing loss worldwide. His studies then focused on human genodermatoses and the important role of proteins involved in epidermal cell junctions including gap junctions. His current studies include the cellular functions of connexins, genetic and functional studies of desmosomes in skin disease and cardiomyopathy, and the role of ABCA12 in the devastating skin disease Harlequin Ichthyosis.

Staff profile: David Kelsell BSc PhD, Professor of Human Molecular Genetics

I’m proud to have identified a number of genes important in skin conditions, cardiomyopathy and hearing loss, and we are lucky to have state-of-the-art genetic and

molecular facilities that allow studies to be done that were impossible a few years ago.

‘‘

The main focus of my research group is the identification of the genetic and molecular mechanisms underlying skin disease though my research also includes investigating genes important in cardiomyopathy and hearing loss. Examples of skin diseases include atopic eczema in the local Bangladeshi community and the rare but devastating condition Harlequin Ichthyosis. In a more quirky study we identified the first gene associated with nail development.

I teach genetics to the undergraduates and have a number of postgraduate students studying for PhDs. I’ve enjoyed the fact that a number of the medical students have worked in my lab either as part of a module or for experience.

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Senior staff research interests Blizard Institute of Cell and Molecular Science

Parveen Kumar CBE BSc MD DM FRCP FRCP(E) Professor in Medicine and Education, Vice-Chairman MSc in Gastroenterology Professor Kumar is not only a very experienced gastroenterologist but also one of Britain's leading medical educators. She is Professor of Medicine and Education at Barts and The London and is highly appreciated as a teacher by students in the UK and abroad. She is co-author of one of the world's most successful textbooks in medicine, Kumar and Clark's Clinical Medicine (7th edition, 2009 Elsevier) as well as many other books. She has been the VicePresident of the Royal College of Physicians (where she established educational programmes and introduced online Continuing Professional Development), President of the British Medical Association and Chairman of the Medicines Commission UK and is currently President-Elect of the Royal Society of Medicine. She established the first MSc in Gastroenterology in the UK in 1992.

David Leslie MB BS MRCS MD FRCP Professor of Diabetes and Autoimmunity David Leslieâ&#x20AC;&#x2122;s research involves studies using major patient resources (such as patients with adult-onset autoimmune disease and twins with diabetes), and molecular studies on these cases including collaborations with the Human Epigenome Consortium and the NIH in America. Recent studies have led to identification

of a genetic component to protein glycation using healthy and diabetic twins and the characterisation of latent onset diabetes of the adults following a major multi-million pound EU grant to Professor Leslie. Recent studies have led to the development of novel vaccinationtype therapies to limit the disease process in type 1 diabetes which are now proceeding to Phase 3 studies.

scavenger receptor CD36 is a polyspecific receptor of, among others, oxidised LDL and thrombospondin. It is implicated in atherosclerosis, fibrosis and tumour angiogenesis. FATPs are important for the uptake and catabolism of long chain fatty acids and implicated in the development of diabetes and skin disease.

Professor Leslie is an editor of Diabetic Medicine and on the board of Diabetes Metabolism Research and Reviews.

Professor of Immunology, Dean for Research Professor MacDonald is interested in the way in which the gut immune system functions in health and disease, particularly inflammatory bowel disease and coeliac disease. He also has a growing interest in how gut bacteria manipulate gut immunity.

Kenneth Linton BSc(Edin) PhD(Glas) Professor of Protein Biochemistry The Membrane Transport Biology group are funded by the MRC, Diabetes UK and Novartis to investigate the relationship between the structure and function of transport proteins in cellular membranes, and how this relates to human physiology and disease. Three classes of membrane proteins are studied: (1) the ATP Binding Cassette transporters ABCB1, B4 and B11; (2) the scavenger receptor CD36; and (3) the fatty acid transport proteins or FATPs. ABCB1, a multidrug resistance pump, is an important determinant of barrier function at the cellular and tissue level and can confer multidrug resistance on cancer cells. The closely related ABCB4 and B11 proteins are responsible for the transport of lipids and bile salts, respectively, into the bile duct (mutations of either cause a range of cholestatic liver diseases). The

Thomas MacDonald BSc PhD(Glas) FRCPath FMedSci

Ian Mackenzie BDS FDSRCS PhD Professor of Stem Cell Science Ian Mackenzie's group investigates various aspects of the biology of normal and malignant somatic stem cells with support of the MRC/NC3Rs, BBSRC, and cancer charities. Areas of major interest include (a) the role of stem cells in the generation and growth of epithelial malignancies, (b) the nature of molecular and phenotypic differences between malignant stem and amplifying cells, (c) the effects of such differences on therapeutic resistance and stem cell responses to therapeutic agents, and (d) the significance of epithelial-mesenchymal transition occurring within malignant populations.

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Further areas of interest are (a) the roles of connexin expression in the maintenance of the stem cell phenotype, (b) mechanisms associated with transition of stem cells into defined differentiation pathways, and (c) the differentiation of mesenchymal and embryonic stem cells into epithelial lineages.

the treatment of a wide range of conditions, including tumours. Other projects involve the investigation of smooth muscle and neuronal function in intestinal pseudo-obstruction, with the discovery of the underlying disorder for a range of patients with intestinal failure.

Aine McKnight MSc PhD Silvia Marino MD Professor of Neuropathology The focus of Professor Marino’s research group is on molecular mechanisms controlling the development of the central nervous system and on how these very same mechanisms can contribute to tumourigenesis when deregulated. Their work is mainly centred on the biology of neural stem cells and neural progenitor cells, on the pathways and genes involved in control of their proliferation and differentiation, in particular the Sonic Hedgehog pathway and the Polycomb group genes. Moreover the group is investigating pathways and molecular mechanisms involved in the formation, development and progression of brain tumours in experimental models and in human tumour samples.

Joanne Martin MA(Cantab) MB BS PhD(Lond) MA FRCPath Professor of Pathology, Divisional Director – Clinical and Diagnostic Services, Head of BICMS Pathology Group Professor Martin’s research interests lie in neurodegeneration related to motor neuron disorders and to motility disorders of the gut. Her team have identified a new method of drug delivery for

Professor of Viral Pathology Professor McKnight’s research focuses on HIV/AIDS. HIV’s enormous diversity makes vaccine development very challenging. HIV-1 group M viruses are divided into 10 clades (A to K). Circulating recombinant forms (CRFs) arise through recombination between clades within multiply infected individuals. Clade B is almost ubiquitous in the Western world. East London is unique; the patient population comes, and settles, from throughout Africa and Asia resulting in a clade distribution reflecting worldwide distribution. This diversity affords us the opportunity to study how to tackle the problem of cross clade vaccines. We have established clinical patient cohorts - such as those who control viral replication, or do not progress to disease - to study the correlates of immune protection from AIDS. A further research focus is on innate anti-viral activities within human cells that obstruct HIV replication after cellular entry such as Lentiviral-restrictionfactor-2, described by us. Currently Professor McKnight’s group is characterising this, and new restrictions, and mapping the gene(s) responsible.

Adina Michael-Titus Lic Sci M es Sci Doct en Sci Reader in Neuroscience and Pharmacology Dr Michael-Titus has a research programme focused on the development of new neuroprotective treatments with potential in neurotrauma and neurodegenerative disease. She is an inventor of several patents and is currently focused on strategies with significant translational potential. Her recent research has demonstrated the efficacy of erythropoietin analogs and polyunsaturated fatty acids in neurotrauma. Her current research is exploring the therapeutic value of novel metalbinding compounds in spinal cord injury and Alzheimer’s disease. Dr Michael-Titus is the Graduate Tutor for the Centre for Neuroscience and Trauma and Programme Director of the MSc in Translational Neuroscience. The programme will draw on the considerable strengths of the Centre for Neuroscience and Trauma in translational neuroscience, to offer students specialised training in this emerging field.

Simon Myers PhD FRCS(Plast) Director of Postgraduate Diploma in Aesthetic Surgery, Postgraduate Diploma in Burn Care and Postgraduate Certificate in NonInvasive Aesthetic Techniques, Clinical Senior Lecturer in Plastic Surgery and Wound Healing, Honorary Consultant Plastic Surgeon Having completed a PhD in keratinocyte growth and differentiation in wound healing and cultured keratinocyte grafting

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Senior staff research interests Blizard Institute of Cell and Molecular Science

within the CCR, Dr Myers has spent some years as clinical lead for the central London burn service in Chelsea. Current research priorities include the establishment of a burn-care research network in the Southeast of England, with a chair in burn care based at the BICMS, concentrating on the mechanisms of burn wound healing, the complications of burn injury, and therapeutic interventions, and particularly infection control and innate immunity. Educational programmes under development include a WebCT distance learning postgraduate diploma in burn surgery, and an MSc in plastic and reconstructive surgery.

Harshad Navsaria BSc MSc PhD Professor in Cell and Tissue Engineering Professor Navsaria's main interests are in the field of keratinocyte biology and tissue engineering. His current interest in the field of tissue engineering of skin is on the application of stem cell technology and the identification of stem cells, which can give rise to a keratinocyte phenotype. The aim is to establish a stem cell centre within the college from different tissue disciplines with an interest in stem cell biology for translational research. He is currently trying to establish a licensed clean room to provide a service for cell based therapies. His research group in collaboration with others is also studying epithelial/mesenchymal interactions and identifying gene expression in combination with various mesenchymal cell types in different skin pathologies and wound healing. The aim of the

work is to understand the distinction between regeneration and repair of damaged skin. Professor Navsaria also has a research programme to establish invitro sweat gland and 3D hair follicle models. His group is also working on Keloid and Hypertrophic scar biology.

Adrian Newland MA(Cantab) FRCP FRCPath Professor of Haematology, Academic Haematology Unit, Pathology Group Adrian Newland's main research interests are in the fields of Immunohaematology. He has published extensively on apoptosis, and has developed the Guidelines and Clinical Studies in Immune Thrombocytopenia. For the latter, his department and laboratory are the main referral centre in the UK and run the National Registry, with links in North America and Europe. His research has received extensive grant support from the Leukaemia Research Fund, the Wellcome, Barts and The London Charitable Foundation and industry. Papers have been published in Blood, British Journal of Haematology, Oncogene and Cancer Research. He is also Director of the North East Thames Cancer Network, immediate past President of the Royal College of Pathologists and Chairs the NICE Diagnostic Assessment Programme.

Dean Nizetic MD PhD Professor of Cellular and Molecular Biology The long term research theme of Professor Nizetic's group is the study of chromosome and gene dose effects (aneuploidy and

haploinsufficiency) on cellular functions, specifically the phenotypic features of Down’s syndrome (DS), caused by just one extra copy of perfectly normal, chromosome 21. Professor Nizetic is one of the world leading scientists in research into DS-associated leukaemia. Professor Nizetic's group participated in the generation of a unique mouse model for DS, the first mouse to contain the human chromosome 21. This mouse model (article in Science in 2005) represented a major scientific breakthrough in research into aneuploidies. Recently, the research group was the first to use this system as a genetic dissection tool to pinpoint the single HSA21 gene responsible for the NRSF/REST de-regulation, the developmentally earliest disturbance so far seen in DS, in embryonic stem cells (see http://news.bbc.co.uk/1/hi/health/ 7597761.stm).

Edel O’Toole MB PhD FRCPI FRCP DCH Professor of Molecular Dermatology Professor O’Toole’s research focuses on keratinocyte biology. Research includes signalling mechanisms in squamous cell carcinoma invasion and survival, the role of type VII collagen in SCC and normal keratinocyte biology, the role of keratins 6a and K16 in keratinocyte cell-cell adhesion, and determinants of localization of varicella-zoster replication in skin. Professor O’Toole also has an interest in

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John Oxford BSc PhD Professor of Virology Professor Oxford has co-authored two standard texts: Influenza, the Viruses and the Disease with Sir Charles Stuart-Harris and GC Schild and most recently the fourth edition of Human Virology, a Text for Students of Medicine, Dentistry and Microbiology published by Oxford University Press. Professor Oxford has also published 250 scientific papers. His research interest is the pathogenicity of influenza, in particular the 1918 Spanish Influenza strain, which he combines with conducting clinical trials using new influenza vaccines and antiviral drugs. This research has been featured on science television programmes recently in the UK, USA, Germany and Holland. He is Scientific Director of the college research virology company called Retroscreen Virology Ltd www.retroscreen.com).

Tanya Parish BSc (Lond) PhD (NIMR) Professor in Mycobacteriology Professor Parish’s research focuses on the important human pathogen Mycobacterium tuberculosis, the causative agent of tuberculosis, which is

Staff profile: Professor Aine McKnight Professor of Viral Pathology

‘‘

Throughout my academic career, I have had an interest in HIV/AIDS. In 1987, I joined a team at the Institute of Cancer Research, (London), to study the role of neutralising antibodies to HIV-1 and HIV-2 in pathogenesis. I was awarded an MSc in Immunology, and a PhD both by the University of London.

“In 2000, I won a fellowship (RCDF) from The Wellcome Trust to develop an independent research group to focus on non-coreceptor determinants of HIV replication in cells at The Wohl Virion Centre, University College London. I am currently a Medical Research Council (MRC) Senior Non-clinical Fellow (awarded in 2005). “The current focus of my research group is mainly on the interface between HIV and the immune system with regard to humoral immunity and a novel innate immune mechanism (Lv-2) that inhibits HIV replication after cellular entry resulting in abortive infection. The two viral genes involved in overcoming this antiviral effect have already been mapped, and we are currently mapping the host gene(s) involved. Other active research interests lie in HIV tropism and co-receptor use.

‘‘

development of novel treatments for severe skin disease, in particular, the ichthyoses and skin cancer in severe generalised epidermolysis bullosa and collaborates on various genetics projects including genetics of atopic eczema in the Bangladeshi population, pachyonychia congenita, harlequin and syndromic ichthyoses.

“I am also among a number of scientists taking part in a $25.3 million international research consortium searching for an HIV vaccine. The grant is one of the largest awards in a $287 million, five-year programme of 16 grants provided by the Bill and Melinda Gates Foundation to establish an international network of HIV vaccine discovery consortia, known as the Collaboration for AIDS Vaccine Discovery. responsible for the greatest number of deaths from bacterial infections. Her group works on understanding the basic biology of the organism in relation to its ability to respond to the environment (gene regulation, two component systems, stress

responses), as well as the basic metabolic pathways required for pathogenesis (isoprenoid biosynthesis, nitrogen metabolism, cell wall biosynthesis). She is also interested in the identification and validation of novel drug targets using novel genetic methods and

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Senior staff research interests Blizard Institute of Cell and Molecular Science

is involved in the development of imaging technologies to monitor the efficacy of drug treatment. Professor Parish is also the Director of Drug Discovery at the Infectious Disease Research Institute in Seattle. Current funding is from the BBSRC, MRC, European Union and the Bill and Melinda Gates' Foundation.

K John Pasi MB ChB PhD FRCP FRCPath FRCPCH Professor of Haemostasis and Thrombosis Professor Pasi’s research interests lie in gene therapy for haemophilia, molecular pathology of von Willebrands disease, the link between cancer and thrombosis and the mechanisms of inhibitor development in haemophilia A. A gene therapy trial for using adeno- associated virus for the transfer of factor IX for haemophilia B has recently been approved in conjunction with colleagues at University College, London.

Mike Philpott BSc(Wales) DPhil(Oxon) Professor of Cutaneous Biology, Centre Lead for Cutaneous Research Professor Philpott’s research interests lie within two main areas of research within his group. The first is to use the hair follicle as a model to investigate the role of growth and transcription factors in regulating epithelial-mesenchymal interactions and the actions of steroids. Secondly, they are interested in understanding the mechanisms of sonic hedgehog action in skin and especially in

relation to development of basal cell carcinoma and stem cell fate.

Raymond Playford PhD(Lond) FRCP(Lond) FRCPath FMedSci Professor of Medicine Raymond Playford runs a gastrointestinal GI Inflammation and Repair Group. Their overall aim is to understand how the gut maintains itself and rapidly repairs itself following injury. Understanding these processes should help us understand why some people go on to get diseases of the gut and also allow us to develop new therapeutic options. Research interests include: mechanisms of repair in the gastrointestinal tract; use of recombinant peptides to treat or prevent gastrointestinal injury; use of bioactive food products (‘Nutriceuticals’); inflammatory processes in coeliac disease; genetics of coeliac disease and inflammatory bowel disease. John Priestley BA(Cantab) DPhil(Oxon) Professor of Cell Biology Professor Priestley’s research interests focus on the anatomy and neurochemistry of dorsal root ganglion (DRG) and spinal cord neurons, with a particular focus on their response to injury and the organisation of pain pathways. Most of this work involves sophisticated techniques for localisation of biomolecules in tissue sections, together with experimental studies manipulating spinal cord and peripheral nerves in vivo. Studies on DRG neurons, have revealed important principles concerning their regulation by target-derived and injury-derived growth factors. Another major area

of work focuses on spinal cord injury. Current work includes the development of biomaterial-based conduits for peripheral nerve and spinal cord repair, and the development and evaluation of novel neuroprotective agents. This work is funded by Barts and The London Charity, by a spinal injury charity (ISRT), and by a UK-China collaboration programme (ICUK).

David Rampton DPhil FRCP Professor of Clinical Gastroenterology Professor Rampton's main research activities relate to the inflammatory bowel diseases, ulcerative colitis and Crohn's disease. Over the years, he has studied various aspects of the pathogenesis of inflammatory bowel disease, and undertaken therapeutic trials of novel agents aimed at specific pathophysiological targets. More recently, he has been in involved in studies of the use and efficacy of complementary therapies widely used by patients, and has been investigating the pathogenic role of psychological stress and the potential therapeutic benefits of stress reduction in patients with ulcerative colitis.

Ian Sanderson BA MA MSc(Oxon) MB BS MD FRCP(Lond) FRCPCH Professor of Paediatric Gastroenterology, Centre Lead for Gastroenterology Professor Sanderson was the first to show: (i) that the enterocyte has distinct transporters on the basolateral aspect for the exit of different amino acids (published 1980);

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(ii) that enteral feeds are as efficacious in treating children with Crohn's disease as high dose steroids, while showing a significant benefit for growth (1987); (iii) that diet can regulate immune gene expression by the epithelium in vivo (1993); (iv) that short chain fatty acids (SCFA) regulate chemokine and IGF binding protein expression in enterocytes through histone acetylation (1997); (v) that breast milk contains VEGF in high concentrations, and that there is a VEGF receptor on the intestinal epithelial cell (1999); (vi) by epithelial cell-specific transgenic techniques, that chemokine expression by the epithelium orchestrates neutrophil and lymphocyte invasion in vivo (2001); (vii) that diet and age interact at the nuclear protein level to regulate gene expression (2004); (viii) that IL-6 mediates growth retardation in Crohn's disease (2005); (ix) that myofibroblasts enhance chemokine activity of the epithelial cell (2006). As a clinician he has also published many observations, including being the first to describe four new diseases of childhood, two of which involve inflammation in the GI tract.

Gareth Sanger BSc(Nâ&#x20AC;&#x2122;cle) PhD DSc(Manc) FBPharmacolS Professor of Neuropharmacology Professor Sangerâ&#x20AC;&#x2122;s laboratory uses human gastrointestinal tissues, removed as a normal part of surgery for gastrointestinal disorders, to explore human gastrointestinal motility and secretion by measuring different neuromuscular and mucosal functions in combination with immunohistochemistry. The research is currently focused in two main areas. First, the laboratory is investigating mechanisms by which hormones such as motilin, ghrelin and GLP1, released from the gut during fasting or after meals, influence gastro-colonic motility and when disordered, play roles in obesity, nausea and diarrhoea. The second area of research uses similar technologies to investigate the roles of different 5-HT receptors and other products of trypotophan metabolism on small and large bowel neuromuscular function, peristalsis and secretion. In both areas, industrial collaboration means that the laboratory places its science and its human tissue expertise at the forefront of new medicine development.

Armine Sefton MB BS MSc MD FRCP(Edin) FRCPath Professor of Clinical Microbiology Armine Margaret Sefton has been Professor of Clinical Microbiology at Barts and The London since 2003 and holds an honorary consultant contract with the hospital. She is on the Specialist Register for both Medical Microbiology and Infectious

Diseases. She has a particular interest in antimicrobial resistance, dangerous pathogens and education / training. Professor Sefton runs the MSc in Clinical Microbiology which normally has around 25 full-time equivalent students on it. She has been a member of her local Microbiology Specialty Training committee since 1996 and was its chair for six years. She is currently Chair of the Board of Examiners in Microbiology for the Royal College of Pathologists and sits on their College Advisory Training Team in Microbiology, their Specialty Advisory Committee in Microbiology, the joint RCP/RCPath Committee on Infection and the joint RCPath / Department of Health Modernising Scientific Careers Committee. She is also a member of the National Advisory Committee on Dangerous Pathogens

Denise Sheer BSc DPhil Professor of Human Genetics Professor Sheerâ&#x20AC;&#x2122;s research is based on two inter-related themes: the structure and function of human chromosomes and the genetic basis of cancer. Her laboratory is examining the principles that govern higher order chromatin architecture and determine its significance for genome regulation in health and disease. Current approaches include analysis of crucial chromatin modifications during activation of the Major Histocompatibility Complex and during differentiation of neural stem cells. The key goals of her

Barts and The London School of Medicine and Dentistry

Senior staff research interests Blizard Institute of Cell and Molecular Science

cancer research are to expose the critical pathways, provide diagnostic and prognostic information, and identify molecular targets for therapy. In the past, her group identified critical genetic aberrations in a wide variety of malignancies. They are now conducting comprehensive genetic and epigenetic studies of brain tumours, and recently identified activation of the MAPK pathway by RAF gene fusions in pilocytic astrocytomas.

Daniel Sifrim MD PhD Professor of GI Physiology Professor Sifrimâ&#x20AC;&#x2122;s research interests are extensive. Recent investigations include in vitro studies on changes in esophageal mucosa permeability due to stress or exposure to bile acids; in vivo animal studies on pharmacology of the lower esophageal sphincter and TLESRs; analysis of the relationship between esophageal inflammation and motility; the physiology of the esophageal longitudinal muscle layer and esophageal shortening; physiological studies in healthy human subjects on the role of

inhibitory mechanisms in the regulation of primary and secondary peristalsis; the relationship between inhibition in the esophageal body and TLESRs; measurements of tone in the esophageal body; pharmacological studies on TLESRs and reflux; studies in patients with primary esophageal motor disorders defining the role of incomplete inhibitory mechanisms in the pathophysiology of diffuse spasm and achalasia; and studies in patients with GERD characterizing different types of reflux (acid and non acid) during TLESRs.

Andrew Silver BSc PhD Professor of Cancer Genetics Professor Silver leads the Colorectal Cancer Genetics Group. The Group focuses on individualising treatment and surveillance protocols for patients with colorectal cancer (CRC). Current programmes include predicting outcome to pre- and post-operative therapy and recognising which patients with ulcerative colitis will develop CRC. Preoperative therapy has a central role in rectal cancer treatment, but a sizable

number does not respond. We are developing tests that identify patients least likely to benefit from this therapy. Patients with CRC treated post-operatively with chemotherapy often have a cancer that is partly or completely resistant. We are analysing CRCs to identify cancers unlikely to respond to find biomarkers that will permit more tailored therapy. Patients with longstanding ulcerative colitis have an increased risk of CRC. Through collaborations with UC patient surveillance centres we are developing biomarkers for the early detection of neoplastic conversion and cancer.

Mary Sugden MA DPhil(Oxon) DSc(Lond) Professor of Cellular Biochemistry Professor Sugdenâ&#x20AC;&#x2122;s research strengths in the regulation of mammalian metabolism have led to current research projects related to insulin secretion and resistance and associated metabolic diseases (eg type 2 diabetes and cardiovascular disease). This research is undertaken in collaboration with

Barts and The London School of Medicine and Dentistry

Dr Mark Holness, a Reader in the Centre for Diabetes and Metabolic Medicine. They are currently interested in how insulin secretion is regulated normally and how the pancreatic islet compensates for insulin resistance induced by changes in diet or lifestyle, including that associated with late pregnancy, with increased insulin secretion. They believe that by studying how mammalian systems respond to metabolic perturbations, including the development of insulin resistance, they may be able to obtain a better understanding of the fundamental cell biology involved in cellular adaptation.

David van Heel BM BCh MA DPhil MRCP Professor of Gastrointestinal Genetics Professor van Heelâ&#x20AC;&#x2122;s group are researching the inherited causes of human disease - particularly intestinal inflammation. Recent successes include identification of new genetic risk factors for coeliac disease. Many of the risk factors for coeliac disease overlap with type 1 diabetes, suggesting strong similarities between the two conditions. Current research includes: identifying further coeliac disease risk variants, including structural variants; fine mapping existing coeliac disease regions to determine causal variants; understanding how risk variants influence biological function; understanding overlaps between different autoimmune diseases.

We are major users of the Barts and The London Genome Centre for high throughput genotyping, transcriptomics and solexa sequencing.

Ping Wang MD(China) PhD(Sweden) Professor of Experimental Immunology Professor Wangâ&#x20AC;&#x2122;s research interests are in two areas; molecular mechanisms of MHC class I antigen presentation and antigen-mediated molecular signalling in T cells. Studies of MHC class I antigen presentation focus on the mechanisms for controlling the presentability of antigenic peptides by MHC class I molecules in antigen presenting cells (APC). His group is interested in the mechanisms that retain low-quality MHC class I molecules in the ER, especially the function of tapasin. Although APC stably present antigen to T cells, different antigens or different forms of antigen stimulation in a compatible antigen-presenting environment could result in different responses of antigen specific T cells. Based on the findings from their basic research, the group has established a novel vaccine platform to develop therapeutic vaccines for melanoma, HIV and HCV.

Norman Williams LRCP(Lond) MRCS(Eng) MB BS(Lond) FRCS(Eng) MS(Lond) FMedSci Professor of Surgery, Head of Academic Surgical Unit Professor Williamsâ&#x20AC;&#x2122; abiding interest has been the understanding of large bowel function in health and disease and the application of such knowledge to improve the care of patients, particularly from the surgical perspective. He has concentrated on the feasibility of restoring gastrointestinal continuity and normal function in patients who required anorectal excision for benign and malignant disease. He has devised several new techniques including a procedure to replace the anal sphincter completely using an electrically stimulated gracilis muscle and various innovative interventions to improve rectal evacuation. More recently his group has become interested in tissue engineering, and is investigating the interaction between porcine collagen and the human gut with a view to using this in reconstructive colorectal surgery. He has also lead a successful bid to NIHR for the Centre to host one of only two Healthcare Technology Co-operatives designed to bring together patients, doctors, scientists and manufacturers to develop and assess new technology and products in the field of bowel function. Another initiative is to develop a National Centre for Bowel Research and Surgical Innovation.

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Degree programmes Blizard Institute of Cell and Molecular Science

Postgraduate Diploma in Aesthetic Surgery Two years part-time – Distance learning Programme description The Postgraduate Diploma in Aesthetic Surgery is organised by the Centre for Cutaneous Research.

Programme outline This programme is designed specifically to provide a core curriculum for established surgeons or surgical trainees, who wish to practice in the field of aesthetic surgery following completion of specialist training. The programme starts in October and runs for two academic years. The programme consists of a mixture of structured distance learning, DVD/theatre-based clinical teaching, and a dissertation. We cover the entire spectrum of aesthetic surgery with an emphasis on fundamental principles and instruction in a wide range of techniques. Clinical training days will be provided for up to four days, with video links to theatre and live discussions with the operating consultant.

Assessment

The programme covers:

A weekly assignment, of which 80 per cent must be successfully completed. A dissertation must be submitted with an examination at the end of the programme.

• The structure and function of skin, pathophysiology of the burn wound, inhalation injury, the systemic response to burn injury, wound healing and scarring

Entry requirements Qualification requirements for the course are MB BS; MRCS (Part 2) or equivalent. Assessments are made only of those areas relevant to each specialty based on their arena of practice.

• Medicolegal and psychiatric aspects of burn practice

For language requirements, please see the international students section on pages 133.

• The science and use of dressings and tissue engineered products

For further information, please see our website at: www.icms.qmul.ac.uk/courses

Further information Sam Matthew Tel: +44 (0)20 7882 7173 email: s.matthew@qmul.ac.uk

Postgraduate Diploma in Burn Care Two year part-time Distance learning Programme description The Postgraduate Diploma in Burn Care is organised by the Centre for Cutaneous Research.

Programme outline The programme is delivered online as eight, ten-week modules over two years. This material is supplemented with DVD material and limited clinical days (two per annum).

• The principles of burn anaesthesia and burn critical care within a multidisciplinary team environment

• The prehospital, and acute care of burn patients • Burn reconstruction, scar management, and burn rehabilitation.

Assessment Assessment is made by weekly essay or MCQ assignments, and a dissertation and exam within the final module.

Entry requirements An MB BS or equivalent is required for entry to the diploma. For language requirements, please see the international students section on pages 133.

Further information Sam Matthew Tel: +44(0)20 7882 7173 email: s.matthew@qmul.ac.uk

Barts and The London School of Medicine and Dentistry

Postgraduate Diploma in Clinical Dermatology One year part-time Distance learning Programme description There are two separate but linked programmes: one for UK-based General Practitioners and one for doctors outside the UK. Successful completion of either programme leads to award of a Postgraduate Diploma in Clinical Dermatology from the University of London. The programme was extensively redesigned in 2009 and combines clinical expertise with innovative technology to facilitate first class training in dermatology.

Programme outline This programme covers core aspects of dermatology over a one year period, with particular emphasis on the diagnosis and management of skin disease from a primary care perspective. There are 30 weekly modules, produced by experts in the field. Each module comprises written and audiovisual material and a formative quiz. Key features - UK programme • Seven clinical days with clinical cases, throughout the course of one year • Small group consultant-led teaching • Weekly interactive web-based material

• Weekly audiovisual material to demonstrate cases and good practice Key features – International programme • This programme can be studied anywhere. No travel to the UK is required • Regular small group tutorials, with live chat • Live interactive lectures • A discussion forum allows for discussion of cases and topics at your convenience • Weekly audiovisual material to demonstrate cases and good practice

Assessment Students are required to write a dissertation and to pass a written final examination. All students must complete at least 80 per cent of the weekly formative assessments during the year. Please see our webpage for more detailed programme information: www.londondermatology.org For language requirements, please see the international students section on pages 133.

Further information Sam Matthew Tel: +44 (0)20 7882 7173 email: s.matthew@qmul.ac.uk For informal enquiries, please contact Dr Vicky Jolliffe Programme Director Tel: +44 (0)20 7882 7169 email: v.jolliffe@qmul.ac.uk

MSc/Postgraduate Diploma in Clinical Microbiology One year full-time, two years part-time Programme description The programme develops your skills and understanding in clinical microbiology, and provide a thorough knowledge of associated subjects (eg molecular biology). The formal teaching includes lectures, practicals and workshops. The lecturers are specialists in their fields and are invited from many institutions in the UK. The practicals are extensive and give you the maximum hands-on experience in all aspects of clinical microbiology. The practicals are taught in a large purpose-built teaching laboratory. Many students use the MSc as preparation for the MRCPath examinations and the MSc is accredited by the Association of Clinical Microbiologists as part of the training for clinical scientists.

Programme outline Your studies are broad-based, with extensive coverage of the following topics: bacteriology • virology • mycology • parasitology • bacterial pathogenicity • immunology • molecular biology • microbial disease – diagnosis, treatment and prevention • antimicrobials and chemotherapy • epidemiology and public health • hospital infection.

Barts and The London School of Medicine and Dentistry

Degree programmes Blizard Institute of Cell and Molecular Science

Assessment

Entry requirements

Further information

There are a series of in-course assessments throughout the programme. These assessments include practical and written examinations, posters, oral presentations, case reports, essays and comprehension of scientific papers. Each assessment is designed as a learning experience as well as a test of knowledge. There are four or five incourse assessments each year and they form approximately 25 per cent of the end of year marks.

If you are a medical practitioner, scientist or nurse currently working in the field of infectious disease the part-time programme is most likely to be the best way to study the MSc. Part-time applicants must hold an appointment or attachment in a microbiology department of a hospital, HPA or other appropriate institution for the duration of the programme.

Please contact Michele Branscombe Tel: +44 (0)20 7882 7216 email: m.branscombe@qmul.ac.uk

The final examinations at the end of year one include a practical exam and a written paper. The final examinations at the end of year two include two written papers, a research project or dissertation and a viva.

If you are an overseas student or a recent graduate in biomedical science you are more likely to want to follow the full-time programme. Graduates in other related disciplines are considered for either programme provided they have suitable experience in microbiology. For language requirements, please see the international students section on pages 133.

For informal enquiries, please contact Professor Armine Sefton Programme Director Tel: +44 (0)20 7882 8167 email: a.m.sefton@qmul.ac.uk

MSc/Postgraduate Diploma in Gastroenterology One year full-time (MSc) Eight months full-time (PgDip) Distance learning option available Programme description The Centre for Digestive Diseases is one of the largest academic departments in the UK and includes professors in GI genetics, nutrition, paediatrics, surgery, neurogastroenterology, clinical gastroenterology.

Barts and The London School of Medicine and Dentistry

The programme is designed as a curriculum in gastroenterology, hepatology and nutrition for new entrants into these fields and as an update and extension for those already in it. The programme provides clinicians with theoretical and clinically applied aspects of their discipline with a focus on the relevant basic sciences and research techniques. It is aimed at clinicians wishing to gain strong knowledge of the sciences underpinning the clinical diseases and their management. The programme includes the ‘taught programme’ from October until April and the projects from April until submission in August. Those undertaking the Diploma will complete only the taught programme. The Centre for Digestive Diseases has two endoscopy training simulators and so training in endoscopy on these simulators is provided throughout the year. This will provide basic skills of endoscopy and enhances future training in patients. As a programme based in a large clinical department there are opportunities to observe clinical meetings, audit and occasional clinics or endoscopy sessions in the latter part of the programme. Other opportunities: there are limited opportunities to stay for a maximum of one year after the MSc for a clinical attachment within the Centre for Digestive Diseases. Successful completion

Module 6: Paediatric and Adolescent Gastroenterology

Assessment 1 ‘Taught programme’ • Continuous assessment (including up to six essays) • Two three hour written exams in April 2 Project of the MSc is required. Additional fees apply and places are very limited in numbers. Please indicate on the application form if you are interested in continuing with these opportunities. For selected high-achieving students there are also opportunities to stay in the Centre as clinical research fellows studying for higher degrees (MD(Res) or PhD).

Programme outline The taught programme is organised into six modules. Module 1 and 2: The Scientific Basis of GI Diseases Module 3: Liver and Pancreatic diseases Module 4: Adult GI Diseases I: Upper GI and IBD Module 5: Adult GI Diseases II: Lower GI, Neurogastroenterology, Nutrition

• Written dissertation • Oral viva To be awarded the MSc requires passing both the ‘taught programme’ and the project. To be awarded the Diploma requires passing the ‘taught programme’ alone.

Entry requirements Minimum requirements for applications to the programme are MB BS or basic medical degree from universities recognised by the University of London. For language requirements, please see the international students section on page 133. All students are interviewed by a senior member of the programme before being accepted to ensure they are suitable for the programme and the programme is suitable for them.

Further information Nici Kingston Tel: +44 (0)20 7882 7191 email: n.j.kingston@qmul.ac.uk www.icms.qmul.ac.uk/courses

Barts and The London School of Medicine and Dentistry

Degree programmes – Medicine Blizard Institute of Cell and Molecular Science

Postgraduate Certificate in Noninvasive Aesthetic Techniques Eight months part-time Programme description This intensive programme is designed specifically to provide a core curriculum for established general practitioners, dentists and dermatologists who wish to practice in the field of aesthetic surgery.

Programme outline The programme starts in January and October of each year and runs for eight months. The programme consists of a mixture of structured distance learning, on line multimedia/ live clinical teaching, and four essays. We cover the entire spectrum of non invasive aesthetic surgery with an emphasis on fundamental principles and instruction in a wide range of techniques. Two clinical training days will be provided to demonstrate the practical applications of the theory studied in the course material.

Assessment Each of the teaching packages includes bi-weekly multiple choice exams. A 3,000 word essay must be submitted at the end of each module.

Entry requirements Qualification requirements for the course are MB BS/ DDS or equivalent. For language requirements, please see the international students section on pages 133. For further information, please see: www.icms.qmul.ac.uk/courses

Further information Sam Matthew Tel: +44 (0)20 7882 7173 email: s.matthew@qmul.ac.uk

MSc/Postgraduate Diploma/Postgraduate Certificate in Translational Neuroscience One year full-time Programme description The aim of the programme, which is at present the first of its kind in the UK and Europe, is to provide a thorough training in the main concepts and methods of translational medicine, with a particular focus on unmet needs in diseases of the nervous system and the challenge of developing better therapies. At the end of their studies students will have a detailed knowledge of the drug discovery and development process, and of clinical trial design and methodology and the regulatory environment.

The formal teaching takes place in the Centre for Neuroscience and Trauma at the Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, and includes lectures, seminars, clinical workshops and a research project. The lecturers are specialists in their field and are preclinical scientists and clinicians. There are also invited speakers, who are leading researchers from other UK or international academic institutions and senior scientists from the pharmaceutical industry.

Programme outline The programme provides coverage of the following topics: • Mechanisms of disease and drug targets in the nervous system • Unmet therapeutic needs in major disease areas in neurology • Biomarkers of disease and their role in drug development • Genomics, proteomics, metabolomics, systems biology and bioinformatics • Drug discovery • Drug development • Personalized medicine • Clinical trial design and regulatory requirements • Intellectual property The taught programme starts with a core module which covers fundamental concepts in drug

Barts and The London School of Medicine and Dentistry

Assessment The taught modules are assessed using a combination of final written examinations and incourse assessments. The incourse assessments consist of literature reviews, oral presentations, case analyses and clinical trial protocols. They are designed as a learning experience as well as a test of knowledge. They represent 30 per cent of the module marks. The research project assessment is based on a written dissertation and an oral examination, which represent 85 per cent and 15 per cent of the mark, respectively.

Entry requirements If you are a recent graduate in medicine, pharmacy or biomedical science, you are more likely to want to follow the full-time MSc programme. If you are a medical graduate, dentistry graduate, pharmacist or nurse, or scientist in the public or private sector, and are currently employed, the Postgraduate Certificate or Postgraduate Diploma may appeal more to you

Cheen Peen Khoo, PhD in Adult Stem Cells I am researching the use of adult stem cells to repair the damaged pancreas as future treatment for diabetes. My work primarily focus on the use of stem cells from the bone marrow and blood cells.

‘‘

I am undertaking my research in the Blizard Building, which houses the BICMS, which is made up of many different departments. This closely knit community allows the exchange of ideas and advice, which is important for my development of my research project. Additionally, the Blizard offers excellent core facilities. My supervisors are very supportive of my research. They are very knowledgeable in my field and they have provided me with very useful advice which has helped me to develop the direction of my current research. Additionally, other staff members from different departments have been very helpful in giving me advice related to their own research fields.

‘‘

discovery and development, and continues with five special modules which cover comprehensively specific disease areas. The taught programme is delivered in two half-days per week, throughout the academic year. After the completion of the taught programme, students carry out a research project, which can be library-based, laboratory-based or clinically-based.

During my time at Queen Mary, I have been accepted to do an oral presentation and two poster presentations. Besides having the opportunity to present my results to the scientific community, I have had the opportunity to travel to places that I had not been before, such as Germany and Amsterdam. if you want a shorter programme of study, more compatible with full-time professional activity. For language requirements, please see the international students section on pages 133.

Further information Mr Surinder Pal Tel: +44 (0)20 7882 8605 email: s.pal@qmul.ac.uk

For informal academic enquiries, please contact: Dr. Adina Michael-Titus Programme Director Tel: +44 (0)20 7882 2290 email: A.T.MichaelTitus@qmul.ac.uk

Institute of Cancer

Barts and The London School of Medicine and Dentistry

Institute of Cancer www.cancer.qmul.ac.uk

Institute Director Professor Nick Lemoine email: n.r.lemoine@qmul.ac.uk

Director of Graduate Studies Dr Simon Joel email: s.p.joel@qmul.ac.uk The Institute of Cancer along with the Centre for Epidemiology, Mathematics, and Statistics has been awarded Cancer Research UK Centre status with the aim of enhancing cancer research in the UK and to train the clinical and non-clinical research workforce of the future. This new Barts Cancer Research UK Centre brings together our top-ranked scientists in the medical school with the expert clinical teams in the brand-new Cancer Hospital to push forward laboratory discoveries into benefits for patients. The Centre will particularly focus on pancreatic cancer, as well as breast, ovarian and prostate cancer, leukaemia and lymphoma. The laboratory programme explores the genes that drive cancer, aiming to identify markers for early diagnosis and targets for new therapies. The Barts Centre is at the forefront in cancer gene therapy and stem cell approaches, with a wide-ranging programme of clinical trials of experimental agents.

The Institute currently represents one of the largest cancer research bodies in the UK with extensive infrastructure investment. Under the leadership of the Director, Professor Nick Lemoine, the Institute is at the forefront of both clinically-based research and basic science. The spectrum of research spans laboratory studies in genomics and informatics, through cancer cell biology and target discovery, to biomarker development and clinical trials of novel therapeutics. At present around 30 per cent of the Schoolâ&#x20AC;&#x2122;s research degrees are cancer-related, making the Institute a cornerstone of the Schoolâ&#x20AC;&#x2122;s research activity. The concentration of expertise and state-of-the-art facilities provides an excellent setting for the delivery of postgraduate teaching and research. The Institute is committed to providing its students with a comprehensive set of skills, an invaluable knowledge base and exposure to the most modern technologies, and offers a challenging and innovative learning environment. The experience is designed to further understanding and enhance career prospects in the field of cancer research.

Overview of research at the Institute of Cancer Our research strategy is built on an integrated molecular and cellular approach to the problem of cancer in individuals and in populations. A spectrum of research is underway and includes: therapeutic and diagnostic target identification and validation in both haematological and solid malignancies; clinical trials exploring new therapies; the development of novel molecular approaches for diagnosis, classification and treatment of human cancers; and investigations into the regulation of tumour spread and host antitumour responses. The Institute currently has over 300 personnel within the following six Research Centres:

Centre for Cancer and Inflammation Centre lead: Professor Fran Balkwill This centre focuses on the links between cancer and inflammation, in particular the role of immune cells and mediators found in experimental and human cancers.

Barts and The London School of Medicine and Dentistry

Institute of Cancer

Centre for Cell Signalling

Centre for Medical Oncology

Centre lead: Professor Bart This is a world-class centre of expertise in both basic and applied PI3K signalling research. The programme focuses on the way in which uncontrolled PI3K signalling is one of the most commonly deregulated pathways in cancer.

Centre lead: Professor Andrew Lister This centre has a long and distinguished history in haematooncology, urological and paediatric malignancies, having led several pivotal trials in the treatment of these cancers.

Centre for Tumour Biology Centre for Experimental Cancer Medicine Centre lead: Professor John Gribben This centre focuses on early phase trials of novel therapeutics developed in the Institute of Cancer, as well as recruitment into late clinical trials, including NCRN, pharma-sponsored and investigator-initiated clinical trials open at Barts and The London NHS Trust.

Centre for Molecular Oncology and Imaging Centre lead: Professor Nicholas Lemoine This is an internationally recognised centre of expertise in gene therapy for cancer, with an active programme of clinical trials, as well as programmes for the identification of molecular biomarkers of disease progression and treatment response. It houses the state-of-the-art molecular imaging facilities for both preclinical and clinical studies.

Centre lead: Professor Ian Hart This centre is concerned primarily with understanding the role that cytoadhesion plays in modulating cancer spread and has focused particularly on the involvement of members of the integrin family of adhesion receptors. More information on our research strategy and staff research interests can be found at: www.cancer.qmul.ac.uk

Barts and The London School of Medicine and Dentistry

Senior staff research interests Institute of Cancer

Norbert Avril Dr med Dr med habil MD

Dan Berney MA MB B Chir FRCPath

Reader, Nuclear Medicine, Centre for Molecular Oncology and Imaging Dr Avril works on the use of molecular imaging with positron emission tomography (PET) for non-invasive monitoring of chemotherapy and gene therapy to define (early) markers of treatment response in clinical trials.

Senior Clinical Lecturer, Centre for Experimental Cancer Medicine Dr Berney’s research focus is in prostate, penile and testicular cancers, using tissue micro-array to create high throughput arrays to examine numerous biomarkers.

Fran Balkwill PhD FMedSci Professor of Cancer Biology, Centre Lead, Centre for Cancer and Inflammation Professor Balkwill’s research aims to understand links between cancer and inflammation, especially the role of inflammatory cytokines and chemokines and translate this information into novel clinical trials.

Subham Basu PhD Honorary lecturer, Centre for Molecular Oncology and Imaging Dr Basu’s research interests include understanding signal transduction pathways responsible for both tumourogenesis and the resistance of tumour cells to cytotoxic and other apoptotic agents, as well as the identification and characterisation of the protein substrates of the serine/threonine kinase Akt, an important regulator of several cellular processes frequently deregulated in cancer.

Claude Chelala PhD Lecturer, Centre for Molecular Oncology and Imaging Dr Chelala’s current research work focuses on the development and application of computational solutions to cancer research.

Finbarr Cotter PhD Professor of Experimental Haematology, Centre for Medical Oncology Professor Cotter’s research interests include functional genomics and proteomics for Bcell malignancies (in particular indolent lymphoproliferation including Chronic Lymphocytic Leukaemia (CLL) and Follicular Lymphoma), myelodysplasia and molecular therapy.

Tatjana Crnogorac-Jurcevic MD PhD Senior Lecturer, Centre for Molecular Oncology and Imaging Dr Crnogorac-Jurcevic is working on the development of a biomarker programme in pancreatic cancer, with special emphasis on searching for novel indicators of early disease. She is concerned with the functional analyses of markers expressed early in the development of pancreatic adenocarcinoma.

Pedro Cutillas PhD Lecturer, Centre for Cell Signalling Dr Cutillas is using a range of system biology approaches to quantify cell signalling pathways. Taking leukaemia cells as a paradigm, the aim is to provide insights into the mechanism of oncogenic signalling and how these contribute to the onset and progression of cancer.

Jude Fitzgibbon BA(Genetics) PhD Senior Lecturer, Centre for Medical Oncology Dr Fitzgibbon works on the dissection of the molecular events leading to the development and progression of lymphoma and leukaemia by studying both familial and sporadic cases.

John Gribben MD DSc FRCP FRCPath FMedSci Professor Centre Lead, Centre for Experimental Cancer Medicine Professor Gribben leads studies on immunological responses to leukaemia and lymphoma. The aim is to implement immunological treatments, including allogeneic transplantation, to improve the outcome for patients with haematological cancers.

Richard Grose BSc PhD Lecturer, Centre for Tumour Biology Dr Grose uses genetically modified mouse models and cell culture approaches to delineate the functions of Fgfs and their receptors in epithelial repair and carcinogenesis.

Barts and The London School of Medicine and Dentistry

Senior staff research interests Institute of Cancer

Thorsten Hagemann MD PhD Senior Clinical Lecturer, Centre for Cancer and Inflammation Dr Hagemann’s research group aims to understand the fundamental mechanisms by which cancer associated inflammation promotes tumour progression in pancreatic cancer; with particular reference to the role of macrophages and their phenotype in carcinogenesis.

pathological angiogenesis and wound healing, exploiting the avb3-integrin-null endothelial cells to understand better the mechanism by which avb3integrin regulates growth factor receptors. She is investigating the identification of differentially regulated angiogenesis related molecules as novel candidates for anti angiogenesis therapy.

Helen Hurst MA PhD Gunnel Halldén PhD Senior Lecturer, Centre for Molecular Oncology and Imaging Dr Halldén's research interests include the development of novel replication-selective oncolytic adenoviral mutants targeting prostate and pancreatic cancers. Her focus is the identification of cellular mechanisms involved in the selective cancer cell killing and the synergistic effects of virus and chemotherapy combinations.

Ian Hart BVSc PhD FRCP FRCPath MRCVS FMedSci Deputy Director Centre Lead, Centre for Tumour Biology Professor Hart focuses on integrin expression and function in tumour invasion and progression; regulation of tumour spread specifically by cell adhesion receptors and their associated molecules as expressed at the tumour cell surface.

Kairbaan Hodivala-Dilke PhD Senior Lecturer, Centre for Tumour Biology Hodivala-Dilke using integrindeficient mice to investigate the functions of integrins in

Professor of Transcription Biology, Centre for Tumour Biology Professor Hurst focuses on understanding the role of the AP2 family of transcription factors in the pathogenesis and response to treatment of breast cancer, understanding the gene targets of AP-2 factors in breast cancer and the regulatory mechanisms involved in their expression. In parallel she is working on defining the hallmarks of anti-hormone refractory breast cancer in patient samples and exploring links with AP-2 positive disease.

Li Jia PhD MD Senior Lecturer, Centre for Medical Oncology Dr Jia’s research interests are cellular and molecular mechanisms of cell death and application in the treatment of human leukaemia. Her current work focuses on understanding the regulation of Bcl-2 family of proteins (Bax) by proteasome and implication in the prognosis of chronic lymphocytic leukaemia (CLL) and developing novel anticancer compounds based on nutural occurring peptide.

Simon Joel BSc FIMLS PhD Senior Lecturer, Centre for Experimental Cancer Medicine Dr Joel’s research focuses on the investigation and development of novel therapies and optimisation of the use of established agents, mainly in haematological malignancies. He also works on the development of model systems for evaluating new therapeutic agents, using cell lines, primary culture assays, tumour xenografts and primary tumour material.

Louise Jones MB ChB PhD FRCPath Professor Breast Cancer, Centre for Tumour Biology Professor Jones leads investigations in breast cancer of mechanisms that promote progression of in-situ to invasive disease with the aims of identifying markers which can predict behaviour, and novel therapeutic targets. He focuses on the analysis of the functional significance of phenotypic changes identified in ductal carcinoma in situ in order to identify markers that may predict disease progression, and novel therapeutic targets.

Stephanie Kermorgant PhD Lecturer, Centre for Tumour Biology Dr Kermorgant works on furthering the understanding of the temporal and spatial regulation of tyrosine kinase receptor, c-Met, signalling that lead to metastasis by the emerging concept of ‘endocytic

Barts and The London School of Medicine and Dentistry

signalling’. She is concerned with evaluating how c-Met internalisation and subsequent signalling events regulate tumour cell migration and invasion.

Andrew Lister BA MA MD FRCP FRCPath FRCR FMedSci

Clinical Senior Lecturer Clinician Scientist, Centre for Tumour Biology Dr Kocher leads studies on pancreatic cancer progression with special reference to the stromal reaction in pancreatic cancer. He researches the development of in vitro models of pancreatic cancer, and investigation of pancreatic stellate cells.

Centre Lead, Centre for Medical Oncology Professor Lister’s research group focuses on the pathogenesis and therapy of haematological malignancies. The aim is to improve the prognosis of germinal centre-derived lymphoma and acute myeloid leukaemia through rational design of clinical trials demonstration of prognostic factors that will allow informed risk taking in selection of therapy; and identification of new therapeutic targets particularly in relation to the mechanism of transform of follicular lymphoma to large B cell lymphoma.

Toby Lawrence BSc PhD

Yong Jie Lu MD PhD

Senior Lecturer, Centre for Cancer and Inflammation Dr Lawrence undertakes studies on the cell biology of inflammation and particularly endogenous antiinflammatory mechanisms to reveal insights into mechanisms of chronic inflammation. He is particularly interested in the investigation of the tissue specific role for IKK‚ in inflammation and immunity.

Senior Lecturer, Centre for Molecular Oncology and Imaging Dr Lu’s research interests include identification of regions of the genome of significance in the development, progression and treatment of male urogenital tumours and identification of the genes from these regions likely to be involved. He is involved in studies of genetic alteration as useful markers of tumour behaviour and potential targets for novel therapies.

Hemant Kocher MB BS MS MD FRCS

Nick Lemoine MD PhD FRCPath FMedSci Institute Director Centre Lead, Centre for Molecular Oncology and Imaging Professor Lemoine’s research interests include target identification and validation in studies on the molecular pathology of pancreatic cancer and target exploitation through viral and genetic therapies.

John Marshall PhD Senior Lecturer (Hon), Centre for Tumour Biology Dr Marshall undertakes studies of the biology of the epithelialspecific integrin, avb6 in cancer. He focuses on the development of avb6-antagonists for imaging and therapy, with the aim of

developing novel targeting approaches to avb6-expressing carcinomas.

Stephen Mather BPharm FRPharmS MSc(Biopharmacy) PhD Deputy Centre Lead, Centre for Molecular Oncology and Imaging Professor Mather is concerned with the development of radiolabelled peptides and antibodies for diagnosis and therapy of cancer in clinical and pre-clinical research.

Iain McNeish MA PhD MRCP MRC Senior Clinical Fellow Deputy Director Centre for Experimental Cancer Medicine, Centre for Molecular Oncology Professor McNeish works on utilising abnormalities in the control and execution of apoptosis in ovarian carcinoma cells as potential targets for viral and genetic therapy. He is involved in establishing an early phase clinical trial programme of selectively replicating adenoviruses in women with recurrent ovarian carcinoma.

Silvia Montoto MB BS MD Clinical Senior Lecturer, Centre for Medical Oncology Dr Montoto focuses on natural history and prognostic factors of patients with follicular lymphoma (FL), specifically, the analysis of the risk factors and prognosis of histological transformation in FL patients,as well as the clinical impact of the diagnosis of Fl in patients with diffuse large cell lymphoma (DLCL).

Barts and The London School of Medicine and Dentistry

Senior staff research interests Institute of Cancer

Heather Oakervee BSc MB BS MRCP MRCPath Clinical Senior Lecturer, Centre for Experimental Cancer Medicine Dr Oakervee runs clinical trials in haematological malignancies, multiple myeloma and has been involved in many clinical trials of the new agents recently introduced in myeloma and optimising their use. Her main work now comprises early phase clinical trials, in particular in myeloma and also in trial management.

Daniel Oberg Lecturer, Centre for Molecular Oncology and Imaging Dr Oberg’s research is on in vivo imaging and eradication of tumours using cancer-targeted viruses armed with genes for: visualisation of viral oncolytic activity, local conversion of prodrugs into cytotoxic metabolites and induction of anticancer immune responses.

Bijendra Patel MS FRCS FRCSGen Surg) Clinical Senior Lecturer, Teaching Centre Mr Patel's main academic interest is in virtual reality surgical simulation as a tool for the acquisition and retention of surgical technical skills. As a clinical senior lecturer he has established the MSc in Surgical Skills and Sciences, the UK's first Masters course for surgical training by simulation.

Tom Powles MB BS MD MRCP

Ama Rohatiner MD FRCP

Clinical Senior Lecturer, Centre for Experimental Cancer Medicine Dr Powles research focuses on comparing sequential cancer tissue (or cancer cells isolated from the blood) before and after sunitinib therapy.

Professor of Haemato-Oncology, Centre for Medical Oncology Professor Rohatine’s interest is in the development of curative treatment for haematological malignancy, with special emphasis on diffuse large B-cell lymphoma and follicular lymphoma.

David Prowes BSc PhD Senior Lecturer, Centre for Molecular Oncology and Imaging Dr Prowes’ research aims to understand and target the molecular events involved in the development and progression of prostate and penile cancer.

Manoj Raghavan MA MB BS PhD MRCP FRCPath Clinical Senior Lecturer, Centre for Medical Oncology Dr Raghavan’s research continues to analyse genomic changes in the DNA of relapsed AML, using microarray technologies that cover the whole genome and investigates whether their lowlevel presence at diagnosis can predict who may relapse.

Rodney Reznek MB ChB MRCP DMRD(Diploma in Medical Radiodiagnosis) FRCR FRCP Professor of Diagnostic Imaging, Centre for Molecular Oncology and Imaging Professor Reznek’s work focuses on the use of magnetic resonance imaging and computer topography in the diagnosis, prognosis and treatment of cancer, particularly gynaecological, abdominal, and endocrine cancer.

Rebecca Roylance BSc MB BS MRCP PhD Clinical Senior Lecturer, Centre for Molecular Oncology and Imaging Dr Roylance’s research interests include the identification of genes involved in low grade breast cancer and elucidation of pathways of progression in breast tumorigenesis.

Peter Szlosarek BSc MRCP PhD Clinical Senior Lecturer, Centre for Medical Oncology and Imaging Dr Szlosarek’s group is exploring why argininosuccinate synthetase (ASS), a rate-limiting enzyme in Larginine synthesis, is aberrantly expressed in human cancers.

David Taussig BSc MB BS MRCP FRCPath PhD Clinical Senior Lecturer, Centre for Medical Oncology Dr Taussig’s interests include elucidation of the mechanism by which acute myeloid leukaemia (AML) induces bone marrow failure and the study of leukaemia stem cells.

Barts and The London School of Medicine and Dentistry

Centre Lead, Centre for Cancer Cell Signalling Professor Vanhaesebroek works on understanding the biological functions and signalling mechanisms of the class IA phosphoinositide 3-kinases (PI3Ks), implicated in the control of various cellular processes such as growth, proliferation, survival, differentiation and cell migration. He also uses genetically modified mice in which the genes for these enzymes are inactivated to uncover the functions of the individual PI3K isoforms in embryology, immunological signalling, and in regulation of the actin cytoskeleton as it regulates cell migration.

Yaohe Wang MD PhD Senior Lecturer, Centre for Molecular Oncology and Imaging Dr Wang’s research focuses on the development of replicationselective oncolytic viruses for cancer therapy, examining the modulation of the innate immune response to enhance the antitumour potency of oncolytic adenovirus, and identification of genetic events in tumour cells that affect the life cycle of adenovirus. He is working on the development of a new generation of oncolytic adenovirus and vaccinia virus with increased potency and reduced toxicity based on dissection of the function of viral genes

Bryan Young BSc PhD Professor Molecular Oncology, Centre for Medical Oncology Professor Young is involved in

Staff profile: Professor Bart Vanhaesebroeck Centre Lead, Cell Signalling

‘‘

I studied at the University of Ghent, Belgium, gaining a Masters degree (1985) in Biology (Physiology and Biochemistry) and a PhD (1990) in Molecular Biology. My PhD work focused on immunology and signal transduction by cytokines. I joined the Institute of Cancer to set up the Centre for Cell Signalling, a group with a focus on understanding signalling through PI 3-kinases (PI3Ks), combining fundamental research with efforts to translate findings into diagnostic and therapeutic applications.

Our team proposed the now universally accepted classification and nomenclature of the PI3Ks Philosophical Transactions of the Royal Society of London 1996:351:217, TiBS 1997:22:267). Other team activity includes pioneering the use of so-called 'kinase knockin' mice in which the active site carries a

studies on the pattern and significance of uniparental disomy and microdeletions in leukaemia using high density SNP arrays. He also works on the integration of

mutation in an ATP-binding amino acid residue, leading to inactivation of the kinase. These provide a more adequate physiological model for the effects of small molecule kinase inhibitors than classical gene knockout approaches (Cell 2004:118:274; TiBS 2005:30:194). Partly through these research efforts, p110delta has become a drug target in cancer, inflammation and autoimmunity. These discoveries were successfully incorporated into the drug development programme of Piramed, and is now being further developed by Roche.

‘‘

Bart Vanhaesebroeck PhD

In addition to being a member of EMBO (European Molecular Biology Organisation), I have worked as a consultant for Serono (Geneva), PIramed, AstaZeneca and Intellikine.

large genome-based data sets to develop a functional view of the leukaemia genome. Acute myeloid leukaemia is the main model used.

Barts and The London School of Medicine and Dentistry

Degree programmes Institute of Cancer

Sarit Badiani, MSc in Surgical Skills and Sciences

‘‘

With a background in surgical training, I was interested in undertaking a Masters programme where I could acquire both research and practical skills. Having looked extensively at the various MSc courses available I believe this was the only available programme to cover both these aspects. This MSc is unique in the way it provides an opportunity to be part of, as well as undertake academic research, along with the practical skills training involving the use of endoscopic and laparoscopic surgical simulators. There has always been a high level of support from all members of the department which makes studying here a very positive experience. I would strongly recommended this MSc for anyone wishing to pursue any surgical career. I was aware of Queen Mary's high reputation, and the work carried out at the Institute of Cancer in particular. I was excited to be part of such a highly recognised institution. Overall, I think the facilities associated with the University are of an extremely high standard. There is a real opportunity to be part of something special.

‘‘

I am keen squash player so I try and keep on top of my game. Squash is great physical exercise, and I’ll always enjoy it.

MSc in Cancer Therapeutics One year full-time, two years part-time Distance learning option available Programme description This programme aims to provide you with a clear understanding of the scientific basis underlying the principles and practice of cancer

therapeutics and the development, evaluation and implementation of new treatments. This is underpinned by a thorough knowledge of cancer biology and pathology, research methodologies, drug development and regulatory issues. There is an emphasis on practical skills during the research skills module and the three month laboratory project undertaken during semester three.

On completion of the programme you will: • Have a thorough knowledge of the principles underlying cancer treatment • Be able to demonstrate skills in gathering, recording, analysing and presenting information • Understand the regulatory framework underlying clinical research • Understand the principles of laboratory methodologies applied to clinical trials • Understand the steps involved in developing and implementing new treatments • Be able to apply this knowledge in a professional role • Be able to contribute to the research activity and knowledge base in improving cancer care.

Programme outline Core modules: Research Skills and Sciences • Cancer Biology • Cancer Pharmacology • Site Specific Tumour Treatment • Ablative Therapy • Biological Therapies • Drug Development • Lab Project Optional modules: Imaging • Pathology of Cancer • Genomic Approaches to Human Diseases • Paediatric and Adolescent Oncology • Cancer Prevention and Screening

Barts and The London School of Medicine and Dentistry

Assessment

Further information

Assessment will be based on written assignments, poster and oral presentations, written or MCQ examinations, and a full lab project write-up.

General programme enquiries: Tel: +44 (0)20 7882 2081 email: cancercourses@qmul.ac.uk

Entry requirements The programme is open to graduate scientists, nurses, clinicians and other medical professionals working in healthcare, the pharmaceutical industry or contract research organisations. Entry to the programme will require a degree, or degree equivalent qualification, from a recognised academic institution or an appropriate professional qualification or experience.

For informal enquiries please contact: Dr Simon Joel Programme Director email: s.p.joel@qmul.ac.uk

MSc in Molecular Pathology and Genomics One year full-time, two years part-time Distance learning option available Programme description

For language requirements, please see the international students section on pages XX.

Distance learning option This programme is also available as a distance learning option and is delivered via our web based learning system known as blackboard. You will be able to follow each lecture online via audio recordings and slide/whiteboard content. All written assignments are submitted through the Blackboard system and poster and oral presentations assessed through SKPE/webcam system. You are encouraged to interact with teaching staff and other students in online discussion forums and join group activities and be part of the Institute’s student community.

This programme combines core teaching of disease mechanisms and molecular technologies, with an emphasis on the development of critical and practical skills. It will provide you with the essential knowledge and skills to pursue a research career, either in a clinical or scientific setting, and contribute to the growing need for scientists and clinicians to promote the translation of molecular advances into the clinical situation. On completion of the programme you will: • Demonstrate a core understanding of human pathology and molecular biology • Have an in-depth knowledge of the principles and applications

of molecular technologies as applied to human disease • Be proficient in experimental design, bioinformatics, data mining and interpretation • Demonstrate skills in oral and written presentation and in critical review of the literature • Contribute to the research process through experience of a laboratory project placement • Understand the ethical framework of the research process • An emphasis on development of practical skills is reflected in the Research Skills Module, and the three month laboratory-based project.

Programme outline Core modules: Basic Molecular Biology • Basic Pathology • Cancer Prevention and Screening • Genomic Approaches to Human Diseases • Molecular Diagnostics and Therapeutics • Molecular Pathology of Solid Tumours • Research Skills and Sciences • Lab project Module options: Biological Therapies • Introduction to BioInformatics • Molecular Genetics of Haematologic Malignancies

Assessment Assessment will be based on written assignments, poster and oral presentations, written or MCQ examinations, and a full dissertation write-up.

Barts and The London School of Medicine and Dentistry

Degree programmes Institute of Cancer

Entry requirements The programme will be open to clinicians, graduate scientists, nurses, and other medical professionals working in a clinical, industrial or academic research environment. Entry to the programme will require a good degree, or degree equivalent, qualification from a recognised academic institution or an appropriate professional qualification or experience.

understanding of Operative Gynaecology and Minimally Invasive Skills. Using innovative simulation technology, the aim of this programme is to provide surgeons in training with a year of instruction to develop operative surgical skills.

For language requirements, please see the international students section on page 133.

This course provides ‘hands-on’ practical training to help accelerate the surgical training and improve surgical skills that are essential for building confidence and competence in trainees and thus maximise the training opportunity in NHS.

Further information

On completion you will be able to:

General enquiries Tel: +44 (0)20 7882 2081 email: cancercourses@qmul.ac.uk

• perform basic laparoscopy tasks.

For informal enquiries, please contact Professor Louise Jones Programme Director email: l.j.jones@qmul.ac.uk

• perform laparoscopic procedures (Salpingostomy, Salpingectomy, Tubal ligation and Oophorectomy)

MSc/Postgraduate Diploma in Operative Gynaecology and Minimally Invasive Skills One year full-time, two years part-time Programme description This unique programme offers students a highly advanced theoretical and practical

• perform laparoscopic suturing

• perform specific open surgical skills • understand the tools and methodologies for conducting research. For suitably able students, the course will provide an excellent foundation for MS/MD or MPhil/PhD studies and obtaining grants, in open competition, from the work carried out in their dissertation.This unique programme offers the opportunity to develop or extend expertise in the established and rapidly developing areas of Laparoscopic

Surgery and Gastrointestinal Endoscopy.

Programme outline Core modules: Practical Skills Assessments by simulation and certification by the course tutor • Written examination: A final theory exam consisting of short and essay questions • Continuous Assessments: essay writing, critical appraisals and presentations • Dissertation project write-up and presentation

Assessment You will be assessed in the following ways: practical skills assessments by simulation and certification by the course tutor • written exam: a final theory exam consisting of short and essay questions • continuous assessments: essay writing, critical appraisals and presentations • dissertation project write-up and presentation.

Entry requirements This programme is aimed at trainees in Obstetrics in Gynaecology and specialist registrars, non-carrier grade Surgeons, associate specialists. A medical degree from a recognised institution is required and some postgraduate experience in surgery is desirable. The programme does not involve any direct contact with the patients so GMC registration is not required for overseas doctors.

Barts and The London School of Medicine and Dentistry

For language requirements, please see the international students section on page 133.

Further information General enquiries Tel: +44 (0)20 7882 3847 email: info@surgicalsimulation.co.uk For informal enquiries please contact: Bijen Patel Programme Director email: b.patel@qmul.ac.uk

MSc/Postgraduate Diploma in Operative Orthopaedics and Arthroscopy Skills

Graduate profile: Linsey Madadi Studied: MSc Cancer Therapeutics – graduated 2007 Currently: Studying for a PhD in the Cancer Pharmacology lab within the Institute of Cancer, Barts and The London School of Medicine and Dentistry at Queen Mary. Why did you choose Queen Mary? The Cancer Therapeutics programme most closely matched what I was looking for, combined with the great facilities and location of Queen Mary. What are your career plans in the next five years? To finish my PhD and then either return to my previous role as a clinical oncology and haematology pharmacist, or continue my research in academia or the pharmaceutical industry.

One year full-time, two years part-time

competence in trainees and thus maximise the training opportunity in NHS.

Programme description

On completion you will be able to:

grants, in open competition, from the work carried out in their dissertation. This would encourage more doctors to become clinical scientists.

• perform specific core skills in orthopaedics surgery

Programme outline

The aim of this programme is to provide surgeons in training with a year of instruction to develop operative surgical skills in orthopaedics using state-of-the-art simulation technology. With the modernisation of medical education resulting in a decreased period of surgical training combined with the new EU time directive, trainees must acquire technical skills within a shorter period of time. This programme will help you accelerate the surgical training and improve surgical skills that are essential for building confidence and

• perform basic diagnostic arthroscopy for knee and shoulder • perform arthroscopic procedure • perform Practical specific open surgical skills techniques • understand basic research methods and submission of a dissertation. For successful students, the programme will provide an excellent foundation for MS/MD or MPhil/PhD studies and obtaining

Core modules: Core Skills in Operative Orthopaedic Surgery • Open Surgery Skills • Arthroscopy Procedural Skills • Upper Limb Arthroscopy Skills • Lower Limb Arthroscopy Skills • Research Methods • Dissertation

Barts and The London School of Medicine and Dentistry

Degree programmes Institute of Cancer

assessments: essay writing, critical appraisals and presentations • dissertation project write-up and presentation.

This programme is aimed at surgeons in training, trainee and specialist registrars, non-carrier grade Surgeons, associate specialists. A medical degree from a recognised institution is required and some postgraduate experience in surgery is desirable. The programme does not involve any direct contact with the patients so GMC registration is not required for overseas doctors. For language requirements, please see the international students section on page 133.

Further information General enquiries Tel: +44 (0)20 7882 3847 email: info@surgicalsimulation.co.uk For informal enquiries please contact: Bijen Patel Programme Director email: b.patel@qmul.ac.uk

MSc in Surgical Skills and Sciences One year full-time, two years part-time

Programme description This unique programme offers the opportunity to develop or extend

‘‘

The continuous development of current surgical techniques as well as the constant stream of revolutionary advancements in the surgical field sparked my interest to further broaden my learning in and experience of surgical techniques. However, I did not wish to embark on either a general course or a very classroom-orientated one. The MSc in Surgical Skills and Sciences offered by Queen Mary is unique in offering exclusive surgical skills through interactive learning and training at the state-of-the-art Virtual Reality Surgical Simulation Centre in a low-stress, high-feedback environment. I very much enjoy learning and training at the state-of-the-art Virtual Reality Surgical Simulation Centre which provides me with the opportunity to enhance and develop a broad range of skills including my laparoscopic and endoscopic skills in a risk-free and controlled environment. I would rate the MSc course in Surgical Skills and Sciences very highly in terms of teaching excellence and academic facilities. In addition to the surgical skills training, the weekly journal club presentations have allowed me not only to develop a higher level of scientific appreciation but also to learn how to critically appraise research papers and perform literature reviews. The focused syllabus and scope of the course has enabled me to advance the competencies relevant to my chosen specialty of surgery, both from a surgical perspective and the development of other necessary skills such as academic writing, presentation techniques and organisational/time management abilities.

‘‘

Entry requirements

Dr Georgios Kallis MSc degree in Surgical Skills and Sciences

expertise in the established and rapidly developing areas of Laparoscopic Surgery and Gastrointestinal Endoscopy. The MSc accelerates surgical training and improves surgical skills that are essential for building confidence in clinical

practice. The programme will provide you with a unique opportunity to gain postgraduate training and development in cognitive and motor skills using the surgical simulators.

Barts and The London School of Medicine and Dentistry

The state-of-the-art Virtual Reality Surgical Simulation Centre removes the patient from the equation to allow novice learning and skill mastery to occur in a low-stress, high-feedback environment while protecting the patient from procedural inexperience. You will also be taught techniques of secure suturing, knot tying and bowel anastomosis using non biological materials. This programme will also provide you with a clear understanding of the concept and theories surrounding the issues of research and critical appraisal along with academic writing.

Assessment Practical Skills Assessments by simulation and certification by the course tutor • Written exam: a final theory exam consisting of short and essay questions • Continuous Assessments: essay writing, critical appraisals and presentations • Dissertation project write-up and presentation

Entry requirements This programme is aimed at surgeons in training, trainee and specialist registrars, non-carrier grade Surgeons, associate specialists. A medical degree from a recognised institution is required and some postgraduate experience in surgery is desirable. The programme does not involve any direct contact with the patients so GMC registration is not required for overseas doctors.

This surgical skills gained on this programme aims to enhance your future career prospects in Surgery. If you perform well and express an interest you may be given the opportunity to proceed to MD(Res) or PhD studies.

For language requirements, please see the international students section on page 133.

Programme outline

Further information

The programme comprises of the following surgical skills areas and a research/literature project:

General enquiries Tel: +44 (0)20 7882 3847 email: info@surgicalsimulation.co.uk

Core modules: Basic Laparoscopic Skills • Advanced Laparoscopic Skills • Laparoscopy Procedural Skills (Laparoscopic Cholecystectomy) • Basic Endoscopy skills • Endoscopy Procedural skills (Flexible Sigmoidoscopy) • Endoscopy Procedural skills II (Upper GI Endoscopy) • Research Methods • Dissertation

For informal enquiries please contact: Bijen Patel Programme Director email: b.patel@qmul.ac.uk

Institute of Dentistry

Barts and The London School of Medicine and Dentistry

Institute of Dentistry www.smd.qmul.ac.uk/dental

Institute Director Professor Farida Fortune email: f.fortune@qmul.ac.uk

Institute of Dentistry offers a friendly, focused and successful environment for postgraduate study.

Director of Graduate Studies Professor Wagner Marcenes email: w.marcenes@qmul.ac.uk Barts and The London is an international leader in oral and dental sciences. In the 2008 Research Assessment Exercise, the school was ranked 1st in the UK for 4* and 3* outputs and 2nd in the UK overall, according to the Times Higher Education. Combining a strong tradition of clinical, epidemiological and public health research and a sold research base, Barts and The London is at the forefront of the advancement of dental care. Cutting-edge laboratories and first class facilities enable the work of these research teams and clinical trials to be carried out to the highest ethical and governance standards. The Dental School of The London Hospital Medical College was formed in 1911 and moved into the current Dental Institute building in 1965. Barts and The London School of Medicine and Dentistry was formed in 1995 and merged with Queen Mary, University of London in the same year. The School shares the vision of Queen Mary that learning takes place in a research environment that enriches the teaching process. It also acknowledges its location in east London and embraces the potential this offers for teaching and learning. The

Since 1996 the Institute of Dentistry’s external income has exceeded £5 million. Over 80 per cent of our full-time staff publish on a regular basis in prestigious peer-reviewed international journals. Overall responsibility for the research degree programme is delegated to the Director of Graduate Studies, currently Professor Wagner Marcenes, but day-to-day responsibility rests with the research student’s supervisor. Our policy is that our dental research should always be in the main stream of Biomedical Research, contributing to it and at the same time benefiting from strong interdisciplinary links. Research students are normally initially registered for an MPhil degree and are required to attend a taught course in their first year. On successfully presenting their first year’s research to an academic from outside the Dental School, they are transferred to the PhD.

and Molecular Biology resources are based in the award winning Blizard Building, which is one of the multidisciplinary research facilities housing over 300 Biomedical Scientists. Core research facilities within the School of Medicine and Dentistry also include a new Genomics Centre development for high throughput DNA sequencing, genotyping and realtime PCR; a new Functional Genomics facility containing robotics and microarray readers; and a new Imaging Centre containing confocal and electron microscopy. Biophysics and Biomaterials are based in modern, well-equipped laboratories on the Mile End campus, adjacent to relevant collaborators in the Department of Chemistry and Department of Materials Science at Queen Mary. In addition, the Institute of Dentistry is located in east London and serves the largest multicultural population with high socio-economic diversity in the UK. This provides a unique opportunity to carry out population based studies and infer conclusions to nearly all environments.

Postgraduate resources The well established Centre for Oral Biometrics, comprising the fifth and sixth floors of the Institute of Dentistry, provides a focus for clinical postgraduate activity, offering seminar space, office, computing and clinical facilities. It includes a Dental Metrology Unit equipped with facial laser scan and facial image analysis. Microbiology and Cell

You can find details of staff members, their research interests, publications and contact details on the Institute of Dentistry website: www.smd.qmul.ac.uk/dental

Barts and The London School of Medicine and Dentistry

Institute of Dentistry

You will also find titles of theses written by current research students, as well as links to other sources of information within the College at: www.smd.qmul.ac.uk/postgraduat e/index.html)

Research degrees The Institute of Dentistry has a long tradition of high quality and original research. There are about 40 academic members of staff actively pursuing research programmes, about half being basic scientists. We currently have about 56 research students. Within the Institute, research interests cover many areas including physics, chemistry, materials science, anatomy, biochemistry, physiology, bacteriology, cell and molecular biology, pathology and epidemiology, in addition to the various specialisms of clinical dentistry, for example orthodontics, prosthetics, geriodontics, periodontology, oral maxillofacial surgery, paediatric and conservative dentistry. We encourage joint supervision of research students between disciplines, including members of the main Medical School and wider College. Entry requirements are a good science or clinical degree appropriate to the research to be undertaken. Research students may start at any time with the agreement of their supervisor.

For information about applying for a research degree please contact: Professor Wagner Marcenes Director of Graduate Studies Tel: +44 (0)20 7377 7632 Fax: +44 (0)20 7377 7064 email: w.marcenes@qmul.ac.uk

Research areas Research in the Institute of Dentistry is organised within multidisciplinary research groups which provide critical mass of expertise, common interests and a fulfilling academic environment. Major areas of research are: Infection and Immunity, Lead: Dr Robert Allaker, Oral Cancer, Lead: Professor Ken Parkinson, Physical Sciences in Dentistry, Lead: Professor Robert Hill and Clinical and Population Research, Lead:

Professor Wagner Marcenes). Research interests within these groups include the following:

Infection and immunity • Microbial pathogenesis and virulence • Microbial-host interactions and immune defences • Naturally occurring antibacterial peptides and other molecules • Mucosal immune responses • Clinical studies and genetic factors in oral ulceration • Host bacterial reactions in periodontal diseases. • Cell biology of bone formation and tissue regeneration • Risk and prognostic factors in Periodontitis.

Barts and The London School of Medicine and Dentistry

Oral cancer • Oral epithelial ageing and role of telomerase in oral cancer • Epithelial stem cells in cancer • Keratinocyte biology • Biology of tumour invasion and role of integrins. • Clinical studies of treatments in oral cancer • Behavioural factors and smoking cessation.

Physical sciences in dentistry • Physical chemistry of dental caries • X-ray microtomography of dental hard tissues • Crystallographic studies of enamel and biomaterials • Changes in bone structure associated with ageing and tooth loss

• Salivary proteins in enamel homeostasis and dental caries

• Population studies on the burden of oral diseases

• Biomechanical properties of bone and dental hard tissues

• Clinical studies on determinants of treatment outcomes of oral and dental conditions, including oral cancer, Behçets Syndrome, Dry mouth, Periodontal diseases, and malloclusion

• Polymer chemistry and dental materials • Development of polymers for drug delivery devices

Clinical and population research • Clinical and population studies on socio-psychological, economic, and behavioural determinants of oral health inequalities • Clinical and population studies on tobacco cessation in the oral health environment • Clinical and population studies on oral health impact on quality of life

• Clinical studies on minimum intervention • Development of primary care networks for practice based research • Systematic reviews (collaborative work with the Cochrane Oral Heath Group)

Barts and The London School of Medicine and Dentistry

Senior staff research interests Institute of Dentistry

Rob Allaker BSc PhD(UWE) FHEA Reader in Mucocutaneous Microbiology Dr Allaker’s research interests focus on microbial-host interactions in the oral cavity and their relationship to local and systemic disease. The role of antimicrobial peptides and Nitric Oxide in non-specific immunity is currently under investigation. He holds research awards from the St Bartholomew’s and the Royal London Charitable Foundation. His publications include Adrenomedullin and mucosal defence: interaction between host and microorganism, as well as numerous papers on skin and oral microbiology. He currently supervises research students on the following topics: The use of plant extracts in oral hygiene and Adrenomedullin and mucosal defence in the oral cavity.

Paul Anderson BSc(Leeds) PhD(Lond) MInstP CPhys Reader in Biophysics in Relation to Dentistry Dr Anderson’s main research interests are model systems for dental caries; salivary proteins in enamel homeostasis; X-ray microscopy; and diffusion processes in porous solids. His current publications focus on demineralisation in enamel and hydroxyapatite aggregates at increasing ionic strength; GR3D X-ray microscopic study of the extent of variations in enamel density in first permanent molars with idiopathic enamel hypomineralisation; bone formation in polymeric scaffolds

evaluated by proton magnetic resonance microscopy and X-ray microtomography; and X-ray microtomographic study of mineral concentration distribution in deciduous enamel.

Lesley Bergmeier CBiol MSB FHEA PhD(Lond) Senior Lecturer in Applied Mucosal Immunology (non clinical) Dr Bergmeier’s research focuses on mucosal immunology. Her background has been in the development of mucosal vaccine in particular the development of vaccine strategies against HIV. This work has expanded to include investigation of innate and cognate responses to novel adjuvants (heat shock proteins HSPs) in relation to viral proteins and the HIV co-receptor CCR5. Recent projects included the induction of immune responses to peptide bound to human heat shock protein as a vaccine strategy against HIV infection. Investigation of the immunomodulatory properties of HSPs has also involved studies of their involvement in Behçets and Crohn’s Diseases, both of which have significant oral manifestations. The main focus of the current research is to understand the oral proteome in the context of oral manifestations of health and disease.

Ray Croucher BSc MA PhD(Lond) ILTM Professor of Community Oral Health, Associate Dean for Dental Postgraduate Taught Programmes Professor Croucher’s research career has focused on psychosocial risk factors for oral diseases. Initially he worked in dental health education programmes for adolescents and the young child. Current interests are multidisciplinary studies of stress as a risk factor for periodontal disease, the role of tobacco use in oral and systemic diseases, the potential role of the dental workforce in tobacco cessation and the development of alternative models of service delivery for underserved populations. He manages a tobacco cessation programme for east London’s Bangladeshi community. Professor Croucher has published widely on these topics. He is the joint author of Achieving Oral Health, recently translated into Japanese, and a collaborator in the newly published text Dental Public Health: a primer.

Alan Cruchley PhD(Lond) Senior Lecturer in Oral Pathology Dr Cruchley’s research activity is primarily concerned with the defensive and protective capacity of oral mucosa. More recently, this has expanded into exploring the role of permeability barrier in disease; drug delivery within the oral cavity; mechanisms involved in oral permeability barrier repair; the role of saliva derived growth factors in oral mucosa; and the

Barts and The London School of Medicine and Dentistry

response of the oral mucosa to external challenge. This has included exploring the effect of aetiologic agents associated with the development of oral disease (mercury; paan extracts) as well the effect of oral health products and dental materials.

Elizabeth Davenport BDS PhD MSc(Lond) FDS RCS ILTM Professor of Dental Education Professor Davenport’s research interests focus on the delivery of education in the dental setting. This research has resulted in the development of a Progress File Learning System for use by undergraduate dental students, supported by funding from the Government Office for London. An Electronic Progress File for the dental education continuum is in ongoing development. She received the IADR Education Research Group Travel Award for work completed in this area. Professor Davenport also retains an interest in the investigation of the relationship of maternal periodontal disease and the delivery of pre-term and low birth weight infants.

Graham Davis BSc (Eng) PhD (Lond) Reader in 3D X-ray imaging. Dr Davis’s background is in electronic engineering and his primary research interest is the development and application of Xray microtomography (XMT). He has developed a unique XMT scanning facility here that is optimised for obtaining high quality 3D images for mapping

and quantifying mineral concentration in biological hard tissue. His scanners have also been used in a variety of other fields and he currently holds an EPSRC grant to develop a new system sensitive enough to resolve ink in rolled parchment (a team of computing engineers at Cardiff University are working on software to take these images and virtually unroll them). The ultimate is to be able to read historical scrolls that are too damaged to unroll. At the same time, this will also provide the next generation scanner for continuation of hard tissue research.

Stephanie Dowker BSc(Nott) PhD BDS(Lond) CChem MRSC Senior Lecturer in Conservative Dentistry Dr Dowker’s main research interests focus on physicochemical mechanisms of de- and remineralisation in dental tissues and synthetic analogues, the chemistry and crystallography of apatitic calcium phosphates, and x-ray absorption methods for quantitative imaging. Her research is supported by the MRC, EPSRC, St Bartholomew’s and The Royal London Charitable Foundation, as well as industry.

Farida Fortune CBE BDS MB BS MRCP PhD FRCP FDSRCS FRSA and DipEdT (Med and Dent) Dean of Dentistry, Director of the Institute of Dentistry, Professor of Medicine in Relation to Oral Health Professor Fortune is the Director for the Institute of Dentistry and

Centre Lead for the Centre for Clinical and Diagnostic Oral Sciences (CDOS) which includes oral biology, oral microbiology, oral pathology, oral medicine, oral surgery and oral and maxillofacial radiology. Her research focuses on the role of inflammation and immune related mucosal diseases. She is especially interested in the influence of genetic profile on inflammatory mucosal disease; the microenvironment changes and the genetic basis of oro-facial Crohn's Disease; the influence of inflammatory status on wound healing and the prognosis and the regulation of healing in normal, fibrotic and ulcerative lesions affecting the oral mucosa. The Centre has established a major research group in head and neck cancer. She is also involved in educational and research support projects in HIV/AIDS as well as supporting African researchers. In addition she has contributed widely both to undergraduate and postgraduate dental and medical education, especially the speciality of human disease.

Mark Hector BSc BDS PhD(Lond) Professor of Oral Health of Children Professor Hector’s research centres on the physiological control of oral function, specifically how salivary calcium interacts with salivary proteins to prevent demineralisation and promote remineralisation of deciduous and permanent enamel; the physico-chemical aspects of dentine and tooth

Barts and The London School of Medicine and Dentistry

Senior staff research interests Institute of Dentistry

sensitivity; and the development and validation of a numerical model of food comminution. In this research he collaborates with colleagues both within and outside Queen Mary.

Robert Hill BSc MsC PhD(Lond) DIC Professor of Physical Sciences in Relation to Dentistry Professor Hill’s research centres on degradable glasses, bioactive glasses, restorative dental fillings, glass (Ionomer) cements, glassceramics, demineralisation, remineralisation phenomena and caries, toothpastes, mode of action of strontium and fluoride on hard tissues. He is currently working on new biodegradable cements for use as adegradable bone glue. He is the UK representative of technical committee four of the International Congress of Glass that deals with glasses for medical applications and the UK representative on Technical Committee seven that deals with nucleation and crystallisation of glass.

Ama Johal BDS MSc PhD FDSRCS MOrthRCS FDS(Orth) RCS Senior Clinical Lecturer Dr Johal’s principle research areas include sleep-related breathing disorders and quality-oflife issues. He has published widely and both his clinical and research work has been rewarded by numerous national prizes and an international prize. He is subeditor of the European Journal of Orthodontics and is academic

lead in Orthodontics, which has recently established a PhD programme.

Ian McKay BA Dphil(Oxon)

Senior Lecturer in Restorative Dentistry Dr Kingsmill’s main research interest centres around the bone changes that occur in the jaws following tooth loss, and the effects of osteoporosis. In some individuals the bone loss is so excessive that it is difficult to provide any satisfactory form of tooth replacement (eg dentures with or without implants). She currently holds a research award from the Department of Health. She has published several papers on this topic and has given talks both nationally and internationally on the subject.

Lecturer Dr McKay is part of the group investigating the risk factors for the development of periodontal disease. Current work focuses on the relationship between genetic polymorphisms and the levels of proteins including interleukin-1a and matrix metalloproteinases in the gingival tissues. The aim is to identify genetic risk factors for the development of periodontal disease and understand how theses may act at the cellular level. Other ongoing research includes the analysis of the cellular activity of novel bioactive ceramic materials and especially the role played by silicon in mineralisation of bones and teeth. Dr McKay’s work has resulted in the recent award of a grant from the NIHR.

Helen Liversidge B Ch D MSc PhD(Lond)

Wagner Marcenes BDS MSc(Brasil) PhD(Lond)

Senior Clinical Lecturer Dr Liversidge’s research centres on the worldwide variation in the timing of permanent tooth formation; application of dental maturity standards to estimate age; third molar development and estimating age of majority. She has collaborated with researchers in South Africa, East Africa, West Africa, Italy, Middle East, Malaysia, Brazil, Japan, Australia, New Zealand. She is an associate researcher in the Human Origins section of the Natural History Museum, London. Her research has international importance in the field of forensic dentistry and anthropology.

Professor of Oral Epidemiology Professor Marcenes' research programme has concentrated on establishing a new paradigm to further elucidate oral health inequalities from the social environment, through psychosocial factors, exploring behavioural and biological pathways to oral health. The main focus is on socio-psychological protective (internal and external resources) and risk factors (stress), and their interaction with upstream (ie: environment) and downstream (ie: behaviour) factors. His innovative research adopted the life course approach to elucidating the occurrence of

Ginny Kingsmill BDS PhD(Lond) FDSRCS

Barts and The London School of Medicine and Dentistry

Wagner Marcenes BDS MSc PhD Professor of Oral Epidemiologys

‘‘

I enjoy teaching at the School of Medicine and Dentistry. The innovative curriculum is based on Problem Based Learning, which makes teaching a stimulating experience. My teaching is informed by the belief that it is more effective to provide students with a challenge to allow them to develop reasoning skills and make rational judgments, avoiding giving them the "right" solution to a problem. Students enjoy this approach and the teaching sessions are intellectually stimulating.

The School of Medicine and Dentistry’s strong research culture offers a supportive infrastructure and the opportunity for multidisciplinary research collaboration. Its location in east London provides an exciting research environment for population studies because it resembles the modern multicultural and complex society, and presents the medical and social challenges of we need to address in the new millennium. The opportunity to develop preeminent multi-disciplinary collaborative research projects at Queen Mary has contributed

greatly to my research on explaining oral health inequalities from the social environment, through psychosocial factors, exploring behavioural and biological pathways to oral health. My research programme has concentrated on establishing a new paradigm to elucidate oral health inequalities from the social environment, through psychosocial factors, exploring behavioural and biological pathways to oral health. In a seminal study we demonstrated that oral health is related to work stress (risk factor) and marital quality (protective factor). This work provided a solid reputation and foundation for several collective works that demonstrated the harmful effects to oral health of experiencing unfavourable socio-psychological circumstances (ie negative life events, daily hassles) and socio-psychological status (personal relationship difficulties, risk-taking behaviour), belonging to low socio-economic groups, and living in socially and materially deprived areas. Also, we

showed the protective effect of schooling, favourable sociopsychological circumstances (positive life-events, social/family support) and socio-psychological status (Sense of coherence, locus of control, pro-social behaviour). Furthermore, we demonstrated the plausibility of these relationships through a behavioural pathway (Oral hygiene, diet, smoking, dental attendance). Our next step is to test the interactive effect of upstream (Socio and psychological environment) and downstream (Biomedical factors) determinants of oral diseases, and demonstrate a biological pathway to further explain the relationship between environmental factors and oral health.

‘‘

Staff profile:

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Senior staff research interests Institute of Dentistry

oral diseases and the outcome of treatment. His paper “Does psychological stress mediate social inequalities in tooth loss?” published in 2008 was awarded the prestigious IADR prize for Best Clinical Research in 2009. Professor Marcenes has carried out several clinical trials and population studies to demonstrate the burden of oral diseases in the UK and abroad, which includes impact of oral health status on people’s quality of life. Currently he is leading the oral health group of experts carrying out the Global Burden of Diseases study http://www.globalburden.org/.

Valeria Marinho MSc PhD(UCL) Senior Lecturer in Bioinfomatics Dr Marinho joined the Centre for Adult Oral Health in April 2005. Previously she worked at the Department of Epidemiology and Public Health (UCL), and for both the Cochrane Neuromuscular Disease Group at Guy's, King's and St Thomas' School of Medicine (King's College London) and the Oral Health Specialist Library (National Library for Health – NHS). As part of her PhD, and under the aegis of the Cochrane Oral Health Group, she has conducted a series of systematic reviews on topical fluorides for caries prevention, of impact on national and international level/practice. Her main research interests are in evidence synthesis, and systematic reviews methodology, with particular applications in dental health, public health, and

evidence based health care. Dr Marinho is an editor of the Cochrane Oral Health Group, a member of the Cochrane RevMan Advisory Group (Cochrane Information Management System Group), and Chair of the selection panel for The Cochrane Collaboration Aubrey Sheiham Public Health and Primary Care Scholarship.

Ken Parkinson BSc PhD(Glas) Professor of Head and Neck Cancer Professor Parkinson’s research interests are focused on mechanisms of human oral epithelial cell ageing and how these mechanisms break down and lead to oral neoplasia. The mechanism of oral epithelial ageing is unknown but may involve the reduction of repeat sequences at the chromosome ends (telomeres) due to insufficient telomerase and/or the accumulation of the cell cycle inhibitor p16INK4A. The ability to understand and manipulate epithelial replicative lifespan may have therapeutic benefit in a wide range of human diseases, including cancer and ageing. Professor Parkinson is a member of the European Telomerase Consortium and currently holds grants from the European Community and CR UK.

Mangala Patel BSc MSc PhD(Lond) Senior Lecturer in Dental Materials Dr Patel’s research activity is primarily concerned with the

development of novel polymeric materials for use in clinical dentistry and orthopaedics, based on the fundamental principles of polymer science. In orthopaedics her work has resulted in a bone and cartilage repair material. Biocompatible, low shrinkage methacrylate based systems, involving detailed studies of physico-mechanical properties have also been developed. Other work includes the general evaluation of proprietary dental materials. Further research centres on developing novel polymeric drug delivery systems (biomaterials) for the transport of therapeutic (active) species, locally within the oral cavity and in the body, including detailed studies of the kinetics of water absorption and release of active agents. Dr Patel was awarded an ESPRC grant for her work on formulating a self disinfecting alginate impression material.

Sharanbir K Sidhu BDS MSc PhD(Lond) MFDSRCS FADM FICD Clinical Senior Lecturer/Honorary Consultant in Restorative Dentistry Dr Sidhu’s main research activities are in dental materials, adhesion as well as interfaces with hard tissues, and she is a leading authority on glass-ionomer materials. She has published extensively and presented internationally. Other areas of research include dentine perfusion, laser preparation of teeth, and interest in dental materials and the biological interface as well as cariology. She has previously been awarded a

Barts and The London School of Medicine and Dentistry

Anwar Tappuni LDS RCS, PhD(Lond), MRACDS (OM), FHEA Clinical Senior Lecturer in Oral Medicine Anwar Tappuni is the Academic Lead for Oral Medicine. She is responsible for the management of the undergraduate and postgraduate subject programmes. Dr Tappuni is a member of the Royal College of Surgeons Examination Board for Diploma in Special Care Dentistry and Chair of the BDA Refugee Dentists Stakeholder Forum. She has a special interest in the oral manifestations of HIV/AIDS and is a member of the International Scientific Committee for Oral Health and Disease in AIDS. Her research focus is on the cause and effect relationship in oral disease. Currently she is involved in research projects on dry mouth and Behçets disease. Dr Tappuni has developed a subjective method for assessing and scoring the severity of ulcerative disease. She has supervised and published

Staff profile: Dr Muy-Teck Teh Lecturer in Head and Neck Cancer

‘‘

My research interests are focused on finding new biomarker genes for predicting early oral cancer formation. Currently studies are based around a known cancer gene called FOXM1B using human oral keratinocytes cells as the research model. Early results have showed that FOXM1B may be an early cancer marker which is expressed at a higher level in pre-cancer and cancer cells compared to normal cells. The future aim is to develop a diagnostic test using the Gene Chip technology that can guide treatment strategy.

‘‘

prestigious international research award, the 2001 IADR Toshio Nakao Fellowship, from the International Association for Dental Research and has been on funded research sabbaticals working under eminent authorities in the USA and Japan. She has also been a member of the Editorial Board of one of dentistry’s most highly-ranked journals, the Journal of Dental Research, for two terms since 2001 and is a member of a committee at the International Association for Dental Research.

research projects on the development of a novel method for examining and diagnosing skin and oral vascular lesions and a technique for the assessment of the swelling of the lips in patients with oro-facial granulomatosis. She is on the BDA Roll of Distinction for outstanding service to UK dentistry.

Ahmad Waseem BSc MSc MPhil PhD (AMU, Aligarh, India) Reader in Oral Biology Dr Waseem’s research interest focuses around the mechanisms identifying molecular markers of head and neck cancer that can be used in the diagnosis of the disease, which can then be employed in clinical settings. His aim is to decipher the molecular pathways that are altered in oral cancer and this knowledge will be employed to identify the molecular perturbations in the disease, which will lead to the development of novel treatment

modalities. Dr Waseem is a member of the Editorial Board of the International Journal of Dentistry.

Hong Wan BSc MSc PhD(Liverpool) Non Clinical Senior Lecturer in Molecular Immunobiology Dr Wan originally was trained in dentistry and moved to research after having obtained her PhD in the Department of Clinical Engineering, Faculty of Medicine, University of Liverpool in 1995. Her research focuses on desmosome junctions in normal epithelia and diseases, particularly, in recent years, on the novel role of the desmosomal cadherin, desmoglein 3 (Dsg3), in the regulation of cell-cell adhesion, cell proliferation, differentiation and morphogenesis and also on its modulation in diseases such as oral cancer and pemphigus. This study has been made possible after her

Barts and The London School of Medicine and Dentistry

Senior staff research interests Institute of Dentistry

successful cloning of human Dsg3 a few years ago. Currently, Dr Wan together with her team are trying to characterise this novel function of Dsg3, which will provide new insight into the broader functions of this gene in epithelial cell biology that is expected to have important implication for our understanding the pathogenesis of various diseases including pemphigus and cancer.

Robert Whiley BSc(Leeds) PhD(Lond) Cbiol MBiol Senior Lecturer in Oral Microbiology Dr Whiley’s main research interests focus on the diversity of the commensal flora of the mouth, particularly the oral streptococci, and the disease associations of opportunistic pathogens. This work has been funded by the MRC and The London Hospital Special Trustees. Current studies include the role of a human-specific cytotoxin produced by Streptococcus

intermedius, a resident of dental plaque that is associated with serious abscesses at non-oral sites. Long-term collaborations exist with colleagues from Queen Mary and Japan. He has published widely on describing new species of streptococci and will be contributing the chapter on the genus Streptococcus for the forthcoming second edition of Bergey’s Manual of Systematic Bacteriology. Dr Whiley is a coapplicant on a recently awarded EPSRC grant which aims to develop a fully functional, selfdisinfecting dental alginate impression material.

Ferranti Wong BDS MSc PhD(Lond) FDSRCSEd FDSRCS(Eng) Professor of Paediatric Dentistry Professor Wong's main research interest is cariology and the management of caries in children. He is a main collaborator of a multicentre clinical trial to investigate a new biological approach in treating caries in

children. Professor Wong's broader interests include dental trauma, dental anomalies and development of dental materials.

Paul Wright BDS PhD(Lond) FDSRCS Professor of Prosthetic Dentistry, Honorary Consultant in Restorative Dentistry Professor Wright’s research interests are firmly based in removable prosthodontics with a strong bias to clinical research. A continual thread of interest in masticatory function has led him into biomaterial research with a defined interest in using soft lining materials and implant-stabilised prostheses. The opportunities offered by implant stabilised prostheses have enabled work on the effects of the occlusion on masticatory function and the effects of prostheses on the supporting tissues, especially bone. Current work includes the development and validation of a numerical model of food comminution and the effects of food surrogates on the long-term durability of soft lining materials.

Barts and The London School of Medicine and Dentistry

Degree programmes Institute of Dentistry

Postgraduate Diploma in Dental Clinical Sciences One year full-time Programme description This programme offers dental graduates a comprehensive grounding in five key training areas: basic sciences and their application to modern day dental practice, principles of clinical issues in dentistry, principles of communication skills, principles of professionalism and principles of management and leadership. This programme aims to recognise previous professional experience and to augment and develop that experience. Two pathways are available. Both provide strong foundations for continuing postgraduate study. Students wishing to undertake the Membership of the Joint Dental Faculties professional examinations (MJDF) are recommended to apply for the core pathway. The enhanced pathway is recommended for those students seeking both Membership of the Joint Dental Faculties professional examinations (MJDF) and the overseas Registration Examination (ORE) or possible progression to a clinical MSc or MClinDent programme.

Programme outline The syllabus is taught through lectures, seminars, tutorials and symposia. Communication and IT

skills are developed through weekly journal club reports and presentations on dental and clinical governance topics. Students will be tutored in Objective Structured Clinical Examinations (OSCE) and Structured Clinical Reasoning (SCR) exams using the facilities in the newly equipped state-ofthe-art Dental skills laboratory

SCR exam. An audit project and clinical case presentation will also form part of the final programme assessment.

All students will observe current UK dental practice via clinics in Oral Medicine, Oral and Maxillofacial Surgery, Periodontology, Paediatric dentistry, Orthodontics, Sedation and General Anaesthesia. They will practice taking radiographs using phantom heads. The enhanced pathway offers students greater emphasis on clinical skills development, using phantom head and teeth.

For language requirements, please see the international students section on page 133.

Students will prepare and continuously update a Professional Development Portfolio for gathering evidence on lectures, tutorials, clinics, self study and self reflection sessions. Upon completion of the programme, students will attain certificates in core skills, required for continuing professional development (CPD).

Assessment Students are continuously assessed through written multiplechoice papers in single-best answer (SBA) and extended matching questions (EMQ) format. The final examination will include two written papers, an OSCE and

Entry requirements Applicants should have a recognised degree in Dentistry from an approved University and 12 months post qualification experience.

Further information Dr Eleni Hagi-Pavli Tel: +44 (0)20 7882 7141 email: e.hagi-pavli@qmul.ac.uk or Ryan Salucideen email: r.salucideen@qmul.ac.uk

MSc in Dental Public Health One year full-time, two years part-time Programme description For dentists and other graduates wishing to pursue a career in dental public health, oral epidemiology and health promotion in a service or university setting, this programme offers supervised experience in the theory and practice of dental public health and the opportunity to develop specialist knowledge and skills. It can contribute to a three year specialist training programme in Dental Public Health. Completion offers

Barts and The London School of Medicine and Dentistry

Degree programmes Institute of Dentistry

eligibility to enter the Diploma in Dental Public Health examination of the Royal College of Surgeons (England).

Students are encouraged to develop appropriate key written, oral, group work and time management skills.

MSc/Postgraduate Diploma in Dental Technology

Programme outline

Assessment

Your programme includes timetabled seminars, personal study and supervised research. All taught modules are considered core modules, although you have considerable choice when selecting a research topic. The taught modules’ content includes:

You are assessed on a modular basis. The assessment procedures vary between each module and include written papers, in which three questions will be answered from a choice, long essays, drafting study protocols, proposing a solution to oral health needs and a critical review of a published paper using appropriate criteria. One third of your final grade is through your completion of a 20,000 word project report. You will also take part in an oral examination based on your project report.

One year full-time, two years part-time

• Oral health needs and demands assessment, including critically evaluating the dental literature, preparing scientific reports, familiarity with indices and determinants of oral disease, epidemiological principles and information sources • Information technology, including computer skills in data analysis, analysing epidemiological data and competencies in common computer software packages • Service planning and evaluation, including resource allocation, measuring service quality and conducting audits • Promoting oral health, including the principles, methods and limitations of prevention and oral health promotion, health determinants and preventive strategies • Research methodologies, both social science and clinical, and the application of scientific principles to research.

Entry requirements We acknowledge professional practice gained from a wide variety of relevant backgrounds, requiring a minimum of two year’s post qualification full-time experience in addition to having a recognised degree. For language requirements, please see the international students section on page 133.

Further information Professor Ray Croucher Tel: +44 (0)20 7882 8662 email: r.e.croucher@qmul.ac.uk

Programme description As a future leader/technician in the field of Dental Technology you will be better prepared to advance your knowledge through research and training, and to strengthen links with clinical members of the dental team. This is an important step in the future education and management of other professionals working in areas complementary to dentistry. This programme is carried out in the School of Medicine and Dentistry and involves both technical practice and academic study. You will be a dentist or basic scientist who may be responsible for the teaching of related subjects, or you may need a greater understanding of the subject in order to plan your future industrial or academic/research careers.

Programme outline This programme includes technical training, formal teaching and a supervised research project. All the taught and technical modules in the programme are core modules. You will be able to select the topic of your research project from your area of interest.

Barts and The London School of Medicine and Dentistry

Assessment If you are following the one-year full-time programme you will be examined on your coursework in June. This will be through two written papers, together with an oral examination on a submitted technical case. The Postgraduate Diploma can be awarded at this point. Your accumulated marks will go towards the final MSc award for which you should also submit a project report by the September of the year that you complete the programme.

Entry requirements Applicants should possess a recognised qualification in Dental Technology through assessments, including a written examination of a standard comparable to a threeyear Foundation Degree in Dental Technology or a Graduate Certificate in Dental Technology (SMD) awarded at the level of merit. A minimum of two years post-initial qualification experience, and the ability to demonstrate advanced Technical expertise in the field, is required. Applicants may also be required to satisfy a practical trade test prescribed by the programme lead before admission.

Jonathan Collier, PhD in Dentistry

‘‘

I researched the role of chemokine receptors in oral cancer metastasis. Oral cancer is a devastating disease and this study focused on a possible mechanism by which these tumours spread around the body. There is an enormous amount offered by the College with regards to facilities and further development. As a clinician it was important to be close to a major teaching hospital. The facilities are first class and there is a huge diversity of departments within the College that really facilitates collaborative research. If you are stuck and don’t know how to tackle something then there is a wealth of resources (academic and practical) available to help you.

‘‘

The programme comprises eight modules and technical practice, covering Statistics, Ethics and Research Methods, the Properties of Dental Materials, Occlusion, an Introduction to Implantology, Aesthetics, Technical Practice and a Project Report.

I was proud to be able to present my work in competitions at the national and then the international conferences for dental research. The latter was in Brisbane, Australia – and the bonus was I won! Other applicants require a degree (minimum of second class honours) in a subject relevant to Dentistry, such as basic sciences or medical/bioengineering, or the equivalent in professional qualifications and experience. For language requirements, please see the international students section on page 133.

Further information Dr Mike Cattell Tel: +44 (0)20 7377 7000 ext 2160 email: m.cattell@qmul.ac.uk

Graduate Certificate in Dental Technology Four months full-time Programme description This programme is designed to help future leaders/technicians in the field of Dental Technology, without a degree, to build on their qualifications and to improve their skills and knowledge before considering entry to Masters level education. The on-campus Graduate Certificate programme is conducted over four months at level 6. Successful completion of the Certificate will allow students to progress to the Diploma/MSc in Dental Technology. This

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Degree programmes Institute of Dentistry

programme is also available to applicants with a dental/science qualification who may be responsible for teaching of related subjects.

Programme outline This programme includes formal teaching, technical practice and a supervised project. All the taught modules in the programme are core modules. You will be able to select project topics according to your area of interest. The programme comprises four modules: • Basic Science I • Basic Science II • Technical practice • Project.

Assessment Students will be expected to complete 12 essays as coursework assessments which will constitute 40 per cent of the total marks for the Graduate Certificate. At the end of Module four, students will be examined by two written papers on the subjects covered. A project report and oral examination will also be expected. A reflective practice log book will be kept for the technical work.

Entry requirements Applicants should possess the appropriate broad-based training, experience and knowledge for entry. This might be measured by possession of a recognised Dental

Technology qualification (see below), a minimum of two years post-initial qualification experience, and the ability to demonstrate advanced technical expertise in the field. Applicants may be required to satisfy a practical trade test.

MSc in Experimental Oral Pathology (Oral Sciences)

A recognised qualification in Dental Technology through assessments, including a written examination of a standard comparable to the Higher National Certificate in Dental Technology or the Dental Technicians Advanced Certificate of City and Guilds of London Institute.

Programme description

A minimum IELTS score of 6.5 (or an equivalent alternative qualification) is also required for overseas students where English is not the first language. For language requirements, please see the international students section on page 133. Students will be required to complete the Graduate Certificate to progress to the Postgraduate Diploma/MSc.

Further information Dr Mike Cattell Tel: +44 (0)20 7377 7000 ext 2160 email: m.cattell@qmul.ac.uk

One year full-time

This one year full-time programme is designed as an introduction to the principles of experimental pathology applied to oral disease. It is principally intended to provide a grounding in experimental method for dental graduates who plan to follow either a career in academic dentistry or one of the clinical specialities. It also provides an opportunity for science graduates to learn about oral disease, in preparation for a career in dental research. The programme offers fundamental training in the principles of laboratory research methods and the range of techniques used to study the behaviour of oral tissues in health and disease.

Programme outline Your programme will be modular, focused on acquiring laboratory skills and knowledge. The taught modules provide the basic understanding to help with the research component. There is a structured course of seminars with associated practical work, dealing with the structure and behaviour of cells and tissues in health and disease. This core begins with fundamental and general concepts of cell biology

Barts and The London School of Medicine and Dentistry

Graduate profile: Oluyori Adegun Studied: MSc in Experimental Oral Pathology â&#x20AC;&#x201C; graduated 2006 Currently: PhD in Dentistry Why did you choose Queen Mary? I chose Queen Mary, because of the diverse cultural environment but more importantly, its reputation as a University par excellence for high quality teaching and research in Dentistry. What did you gain from your time at Queen Mary? I researched the role of Human Papilloma-virus 16 (HPV16) in Oral cancer at the new, open plan Blizard Building, which provided access to excellent facilities and the opportunity to collaborate with a diverse range of research groups. I particularly enjoyed presenting my research via posters at international conferences, such as the British Society of Oral and Maxillofacial Pathologists day. I was privileged to get a publication in an international journal and the rare chance of meeting high profile clinicians, researchers and executives. Overall, my experience on the MSc was so enjoyable that I inevitably wanted to continue my research here. After graduating with a Distinction, I am delighted to now be a PhD student, researching diagnostic imaging for oral mucosal diseases. What your career plans in the next five years? On completion of my PhD at Queen Mary, I intend to undergo a specialist training in Oral Pathology with a view to having an excellent background in the pathologic basis of Oral diseases. and continues with the application of these concepts to a consideration of oral and dental disease. Related disciplines such as oral microbiology and immunology are also covered.

Throughout the programme, emphasis is placed on the evidence upon which the concepts are based and the way in which such evidence is obtained by observation and experiment. You are actively encouraged to take part in the seminars.

Running in parallel with the core programme are several related series of seminars dealing with research methods, statistics and techniques of fundamental importance to experimental pathology such as tissue culture, molecular biological techniques, immunocytochemistry, light and electron microscopy. Students undertake a laboratorybased research project in the final module of the programme, exploring any aspect of oral disease.

Assessment The programme is assessed by two written papers, the submission of a project report and an oral examination.

Entry requirements A degree in dentistry or medicine or a good BSc honours in a biological science subject. For language requirements, please see the international students section on page 133.

Further information Dr Alan Cruchley Tel: +44 (0)20 7882 7134 email: a.t.cruchley@qmul.ac.uk or Dr L Bergmeier Tel: +44 (0)20 7882 8654 email: l.a.bergmeier@qmul.ac.uk

Barts and The London School of Medicine and Dentistry

Degree programmes Institute of Dentistry

• Formulating appropriate hypotheses for investigation • Demonstrating knowledge of clinical techniques and how to evaluate them • Interpreting the results of these techniques • Planning, conducting and reporting original research. Students are encouraged to develop appropriate key written, oral, group work and time management skills.

Assessment The assessment procedures are: • a research report on an individual project • an oral examination on your research report. Candidates will be examined in the year in which they complete their research report.

Entry requirements

MSc in Implant Dentistry One year part-time Programme description For dentists wishing to upgrade their core knowledge and skills of evidence-based dentistry in identifying and understanding the scientific basis of implant treatment.

Programme outline The programme includes timetabled seminars, personal study and supervised research. All programme taught modules are core options, although your have considerable choice when selecting a research topic. The taught modules’ content includes: • Searching, critically reading and analysing the literature

You should have successfully completed the two-year part-time Diploma programme in Implant Dentistry, accredited by the Faculty of General Dental Practitioners of the Royal College of Surgeons of England. For language requirements, please see the international students section on page 133.

Further information Dr Gianlucca Martuscelli Tel: +44 (0)20 7882 8663 email: g.martuscelli@qmul.ac.uk

Barts and The London School of Medicine and Dentistry

MSc in Oral Biology One year full-time Programme description You will join a one year full-time programme, the only UK MSc in Oral Biology. It is designed to be appropriate for both dental and basic or applied science graduates who may in future be responsible for the teaching of related subjects, or who need a greater understanding of the subject in order to develop their future academic or research careers. Oral Biology encompasses a range of basic sciences fundamental to the understanding of the underlying scientific principles relevant to developing modern dentistry. You will study dental anatomy, oral physiology, and dental biophysics, as well as basic biochemistry in relation to dentistry, chemistry of bone and tooth biominerals and components, aetiology of dental caries and erosion, saliva biochemistry, oral microbiology, dental materials science, modern 2D and 3D x-ray imaging.

Programme outline You will follow a group of modules, including Statistics, Ethics and Research Methods, an Introduction to Oral Biology, Dental Hard Tissues and the Microenvironment, Oral Microbiology, Minimally Invasive Dentistry and Properties of Dental Materials. In addition to these

basic science lectures, there will also be lectures from practising clinicians on current issues in modern clinical dentistry.

Programme outline

You will also complete a laboratory based project, which will be partly assessed by an oral examination.

By entering this programme you will embark on: clinical training (30 per cent), laboratory practical sessions (25 per cent) formal seminar teaching (45 per cent). All modules in this programme are core.

Entry requirements

Assessment

A medical or dental degree, a non-clinical degree in basic sciences, biological sciences, or bioengineering, or the equivalent in professional qualifications and experience.

Your progress will be monitored throughout the programme by formative in-course assessments. These may include essays, critical paper reviews and practical tests of laboratory based skills. On completion of the programme, you will be assessed by two clinical case reports of not more than 2,000 words each and an oral examination. Your in-course assessments will contribute up to 40 per cent, the two clinical case reports up to 40 per cent and the oral examination up to 20 per cent of your final mark.

A minimum IELTS score of 6.5 (or an equivalent alternative qualification) is also required for overseas students where English is not the first language.

Further information Dr Paul Anderson Tel: +44 (0)20 7883 7933 email: p.anderson@qmul.ac.uk

Postgraduate Diploma in Endodontic Practice Two years part time Programme description This programme is designed for dental graduates who wish to develop their clinical skills in and understanding of endodontics. The aim is to enable the practitioner to develop and apply the current evidence base to their clinical practice.

Barts and The London School of Medicine and Dentistry

Degree programmes Institute of Dentistry

Entry requirements

Programme outline

You will have a UK dental degree or equivalent (such as IQE), hold full registration with the General Dental Council and have a minimum of two years post-initial qualification experience. Offers to join the programme follow a competitive interview.

By entering this programme you will embark on: clinical training (60 per cent), formal teaching (25 per cent) and research activity (15 per cent). The programme aims to enable you to understand basic sciences related to oral medicine and apply this to North and East Londonâ&#x20AC;&#x2122;s unique clinical case mix. All the taught and clinical modules in the programme are core teaching. The research element of this programme involves a report or a literature review on a topic chosen with the advice of your tutor and a clinical audit report.

For language requirements, please see the international students section on page 133.

Further information Chathura Malalasena Tel +44 (0)20 7377 7057 email: chathura.malalasena@bartsandth elondon.nhs.uk or Dr Sharan Siddhu Tel: +44 (0)20 7882 8617 email: s.k.sidhu@qmul.ac.uk

MClinDent in Oral Medicine Two years full-time Programme description This programme is designed for dental graduates who wish to pursue a career in oral medicine, either in primary or secondary care services or in a university setting. The programme aims to develop your knowledge, understanding and clinical skills in oral medicine and related topics.

Assessment Your clinical activity will be assessed through case presentations and a clinical logbook whilst the taught element will be assessed through one written paper and oral assessment. Your research activity will be assessed by a report of a literature review on a topic chosen with the advice of your tutor and a clinical audit report. Weightings of each of the major components will reflect their contribution to the programme: clinical training (60 per cent), formal teaching (25 per cent), and research activity (15 per cent).

Entry requirements Please refer to the person specification table for all clinical masters programmes in Dentistry on page 75.

For language requirements, please see the international students section on page 133.

Further information Dr Anwar Tappuni Tel: +44 (0)20 7882 8655 email: a.r.tappuni@qmul.ac.uk or Ryan Salucideen email: r.salucideen@qmul.ac.uk

MClinDent in Oral Surgery Two years full-time Programme description This programme is designed for dental graduates who wish to pursue a career in oral surgery, either in primary or secondary care services or in a university setting. It can contribute to the first two years of clinical training leading to the Membership examination of The Royal College of Surgeons.

Programme outline By entering this programme you will embark on: extensive clinical training (60 per cent) formal teaching (25 per cent) and a supervised research project (15 per cent). All the taught and clinical modules in the programme are core modules. You will however have considerable choice when selecting a topic for your research project.

Barts and The London School of Medicine and Dentistry

Assessment You will be assessed at the end of the first year through a written paper and a clinical viva voce examination. At the end of the second year there are two written papers, four case presentations (two seen and two unseen) and a treatment planning exercise. You will also take part in an oral assessment of your research report. At the moment all three major components of the second year exams (written, clinical, research) are equally weighted. During an optional additional third year, you will undertake, if eligible, the Royal College of Surgeons Membership examination. This entails case presentations, clinical diagnostic and treatment planning exercises.

Entry requirements Please refer to the person specification table for all clinical masters programmes in Dentistry on page 75. For language requirements, please see the international students section on page 133.

Further information Dr Judith Jones Tel: +44 (0)20 7882 7154 email: judith.jones@qmul.ac.uk

MClinDent in Orthodontics Two years full-time Programme description This programme is designed for dental graduates who wish to pursue a career in orthodontics either in primary or secondary care services, or in a university setting. The two-year full time Masters programme is integrated into a three-year clinical programme, with a strong emphasis on close chairside support. Students will undertake the MSc examination (University of London) at the completion of their second year and the Royal College of Surgeons Membership examination during the third year. The programme aims to enable you to:

Bana Abdulmohsen, MSc Dental Technology, Syria

‘‘

Queen Mary has a good reputation amongst Syrian students. A friend of mine highly recommended studying here at postgraduate level. It has been a great opportunity to meet colleagues in the same field and exchange knowledge. The College itself is a really friendly environment, with great facilities such as the Library, computers and modern accommodation.

• Understand the biomechanical principles of tooth movement

Ideally I would like to teach as well as practise dentistry, and hope to apply for a PhD at Queen Mary. I enjoy attending conferences and learning about up to date research. I would also like to work on some research and publish articles.

• Understand the development, growth and influence of the skeletal and soft tissues on the dentition

• Apply the theory and practice of clinical orthodontics to treat a variety of malocclusions.

• Understand the importance of materials science in orthodontics • Formulate a diagnosis of malocclusion and appropriate treatment plan

‘‘

The full programme includes patient diagnosis and treatment planning, teeth and root extraction, surgical endodontics, management of dental trauma, implantology and pain management, and anxiety control.

Programme outline By entering this programme you will embark on a course which includes extensive clinical training (60 per cent), formal teaching (25 per cent) and a supervised research project (15 per cent). All the taught and clinical modules in the programme are core teaching.

Barts and The London School of Medicine and Dentistry

Degree programmes Institute of Dentistry

You will however have considerable choice when selecting a topic for your research project. The three-year programme includes the following areas: • Growth and development of the head, face and dentition • Anatomical and physiological considerations of the face and jaws, including the temporomandibular joint • The aetiology of malocclusion • Clinical assessment, diagnosis and treatment of malocclusion • State-of-the-art treatment mechanics • Concepts and practice of retention and stability • Inter-disciplinary care, including surgical and restorative interfaces.

Assessment You are currently assessed at the end of the second year (MSc examination) by two written papers, case presentations, a clinical diagnostic and treatment planning exercise. You will also take part in an oral assessment of your research report. During the third year, you will undertake, if eligible, the Royal College of Surgeons Membership examination (M.Orth). This entails case presentations, clinical diagnostic and treatment planning exercises.

Entry requirements Please refer to the person specification table for all clinical

masters programmes in Dentistry on page 75. For language requirements, please see the international students section on page 133.

formal teaching and a supervised research project. All the taught and clinical modules in the programme are core modules but you will have considerable choice in selecting a topic for your research project.

Further information Lorraine Low Tel: +44 (0)20 7882 8744 email: l.low@qmul.ac.uk

The programme comprises nine modules: 1 Foundation Course

or Dr Ama Johal Tel: +44 (0)20 8662 8651 email: a.s.johal@qmul.ac.uk

MClinDent in Paediatric Dentistry Two years full-time, three years part-time Programme description This programme is designed for dental graduates who wish to pursue a career in paediatric dentistry either in primary or secondary care services, or in a university setting. The programme can contribute the first two years of clinical training leading to Membership in Paediatric Dentistry of The Royal College of Surgeons, Edinburgh and full active membership of the European Academy of Paediatric Dentistry. Both of these options are possible following successful completion of an optional third year of training which is available through competitive entry.

2 Statistics, Ethics and Research Methods 3 Basic Knowledge in Paediatric Dentistry including the following: • Behaviour science/patient management, sedation and general anaesthesia • Dental Traumatology • Prevention of Caries and Periodontal Disease • Diagnosis and Treatment Planning • Basic Orthodontics 4 Advance Knowledge in Paediatric Dentistry I • Consolidation of the Basic Knowledge • Oral Surgery, Oral Medicine and Oral Pathology • Children with special needs 5 Advance Knowledge in Paediatric Dentistry II • Paediatric medicine and surgery • Dental Anomalies

Programme outline By entering this programme you will undertake extensive clinical,

• Multi-disciplinary treatment planning

Barts and The London School of Medicine and Dentistry

6 Basic Clinical Skills and case-mix 7 Specific Clinical Skill 8 Clinical Diagnosis and Treatment Plan

Professor Mark Hector Tel: +44 (0)20 7882 8676 email: m.p.hector@qmul.ac.uk or Dr Ferranti Wong Tel: +44 (0)20 7882 8745 email: f.s.l.wong@qmul.ac.uk

9 Research Project You will undertake the care of child and adolescent patients to gain experience and prepare for your case presentations in the final examination. An important feature of the programme is that you will also participate in medical clinics held in the main hospital. You will also attend specialist clinics such as cleft lip and palate, and developmental disorders.

Assessment Each module is assessed separately, including essays, written, clinical and viva voce examinations.

Further information Lorraine Low Tel: +44 (0)20 7882 8744 email: l.low@qmul.ac.uk or

MClinDent in Periodontology Two years full-time Programme description This programme is designed for dental graduates who wish to pursue postgraduate level education or a career in Periodontology. The programme is recognised by the UK Specialist Advisory Committee in Restorative Dentistry as suitable for the first two years of specialist training in Periodontology. An optional third year of training is available through competitive entry for UK/EU applicants wishing to be entered on the GDC specialist list. This option must be agreed by The London Deanery prior to entry.

Programme outline The programme consists of clinical training, formal taught elements and the completion of a research project and dissertation. The clinical training (60 per cent) in diagnosis and management of periodontal disease emphasises the practice of advanced techniques in periodontology and includes the relationship between periodontology and other dental disciplines. The formal teaching element (25 per cent) is designed to provide a wide scientific background in the practice of periodontology. The supervised research project consists of 15 per cent of total programme activity. All the taught and clinical modules in the programme are core modules. However, you have a wide range of opportunities and topic choices for the research project in our exemplary modern research laboratory and clinical facilities. The full programme includes attendance at weekly new patient diagnostic clinics,

Barts and The London School of Medicine and Dentistry

Degree programmes Institute of Dentistry

clinical practice in periodontology including surgical, antimicrobial, regenerative and mucogingival procedures, management of periodontal disease in patients with other restorative problems, and principles and practice of implant dentistry.

Assessment You are currently assessed at the end of Year One by a single written examination paper and a clinical oral examination on the scientific basis of Periodontology. At the end of the second year there are two written papers, four case presentations, and a clinical diagnosis and treatment planning test. You will also produce a written report of your research project. You will also take part in an oral assessment of your research report. At the moment all three major components of the second year exams (written, clinical, research) are equally weighted.

Further information Dr Kevin Seymour Tel: + 44 (0)20 7882 8663 email: k.g.seymour@qmul.ac.uk

MClinDent in Prosthodontics Two years full-time

You will value the opportunity of attending new patient diagnostic clinics, providing you with the opportunity of formulating complex treatment plans.

Programme description

Assessment

This programme is designed for dental graduates who wish to pursue a career in Prosthodontics. It can contribute to the first two years of the three year clinical training leading to Membership in Restorative Dentistry (MRD) of The Royal College of Surgeons, Edinburgh. Membership is granted following successful completion of an optional third year of training without additional examination. This option is only available through competitive entry. For UK/EU applicants wishing to be entered on the GDC specialist list this option must be agreed by The London Deanery prior to first year entry.

Programme outline The programme comprises extensive clinical training (60 per cent), formal teaching (25 per cent), and a supervised research project (15 per cent). All the taught and clinical modules on the programme are core options. You will have considerable choice when selecting a topic for your research project. The programme includes modules covering all aspects of fixed prosthodontics, removable prosthodontics, implantology and related subjects.

You will currently be assessed at the end of year one by a single written examination paper and a clinical oral examination. At the end of the second year there are two written papers, two case presentations (four for the MRD candidates), a treatment planning exercise, and a clinical test in both fixed and removable prosthodontics. You will also take part in an oral examination of your research report. At the moment all three major components of the second year exams (written, clinical, research) are equally weighted.

Further information Dr Paul D Taylor Tel: +44 (0)20 7882 8619 email: p.d.taylor@qmul.ac.uk

Barts and The London School of Medicine and Dentistry

Person specification for entry to postgraduate clinical dentistry programmes Criterion

Essential

Desirable

Education

Primary qualification in Dentistry - BDS or equivalent.

Primary dental qualification registerable with the General Dental Council in the UK; MFDS, MJDF or FDS or equivalent; Other postgraduate diplomas, degrees; Other evidence of high academic achievement (eg Course grades, award of degree with honours or equivalent. Previous first degree [-BSc]).

Experience

Two years full time (or equivalent) post qualification clinical practice of dentistry.

English Language

English as first language

Evidence of experience of practice of a broad range of general dentistry; Completion of formal Vocational Training course, General Professional Training program, or equivalent such as hospital internship. Specific clinical experience in discipline/specialty to which they are applying.

OR Minimum IELTS score of 7.0 (no less than 6.5 in any part), TOEFL scores as follows: internet based 106, computer based 263, paper based 627 and must have been completed within the last two years. Career intentions

Clear commitment to pursuing postgraduate studies in the one specialty/discipline applied for.

Generic skills

Ability to use a computer and familiar with common programs such as MS Office.

1 You may not apply for more than one speciality in the hope of acceptance on one. We do though recommend applicants consider application for the Diploma in Dental Clinical Sciences course here prior to applying for any of the clinical programmes as it will show commitment and allow us to assess the candidatesâ&#x20AC;&#x2122; work ethic and knowledge before any decisions are made.

Other equivalent tests will be considered on merit.

2 The personal statement should show genuine enthusiasm for the speciality, such as attendance at relevant conferences, membership of appropriate professional bodies and postgraduate course attendance and not be generic in nature.

Institute of Health Sciences Education

Barts and The London School of Medicine and Dentistry

Institute of Health Sciences Education www.ihse.qmul.ac.uk

Institute Director Professor Susan Dilly email: ihse-admin@qmul.ac.uk

Assessment This unit leads in managing assessment within the MB BS courses.

Director of Graduate Studies Professor Clive Seale email c.seale@qmul.ac.uk It comprises three Centres: • Centre for Medical Education • Centre for Health Sciences • Centre for Sports and Exercise Medicine

Centre for Medical Education The Centre is concerned with managing, maintaining and developing teaching. The majority of staff are involved in teaching, largely undergraduate, but also some postgraduate modules. The units within the Centre are as follows: Quality and Education Development This unit concentrates on quality assurance of teaching, faculty development and education research Curriculum Delivery This unit concentrates on the delivery of teaching within the MB BS and degree programmes Human Development This unit leads teaching on women’s health, paediatrics and medicine for the elderly.

E-Learning This unit is developing E-learning for undergraduate modues, and is working closely with IVIMEDS, the international virtual medical school, developing virtual patients and interactive E-learning. Turnbull Centre This unit manages and delivers teaching in the Turnbull Centre, delivering anatomy and medical sciences practical teaching. Performing Medicine This unit is a collaborative project delivering a programme of arts in medicine. The Centre runs an intercalated degree in Medical Education.

Centre for Health Sciences The Centre includes two research orientated units: The General Practice and Primary Care Research Unit and Human Science and Medical Ethics Activities which are consolidated on the Medical School’s Whitechapel Campus, adjacent to the Royal London Hospital. The geographical position of the Centre for Health Sciences in east London, with the surrounding multicultural population spanning the economic spectrum, provides a major focus for our research programme.

We use a wide range of methodological approaches, ranging from observational epidemiology, social surveys and randomised controlled trials, through systematic reviews, to qualitative studies and health policy research to inform the development of health and social care services. The research programme includes five linked domains: 1. Inner-city health service delivery including: • ethnicity and healthcare variation • inequality in health service use and outcomes • Mass media reporting of health topics 2. The evaluation of models of primary and social care development, including: • healthcare responses to domestic violence • primary care development • evaluation of small area variations in health and healthcare • Communication in health care consultations • End-of-life decision-making

Barts and The London School of Medicine and Dentistry

Institute of Health Sciences Education

3. Chronic disease management including: • cardiovascular disease • asthma, COPD and tuberculosis • chronic musculoskeletal pain 4. Health services research • analysis of routine data statistics • decision aids in healthcare • models of service delivery • ethical aspects of research, policy and delivery in public health and healthcare services • statistical method for community based research

5. Ethnicity and Health • evaluation of a school counselling service for Bangladeshi girls who self-harm • ethnic health behaviours in relation to prostate cancer • lifestyle narratives of ethnic adolescents in relation to health behaviour

Centre for Sports and Exercise Medicine The Centre includes two major domains: • The high performance athlete • Health and the general population, physical activity levels and exercise as a health tool

Barts and The London School of Medicine and Dentistry

Senior staff research interests Institute of Health Sciences Education

Cathy Baker BSc PhD Senior Lecturer in Histopathology; Head of Graduate Entrants’ Programme (GEP); Senior Tutor for Medical Admissions Dr Baker’s interests in education include selecting the best students, student learning styles, curriculum development and inter-professional education.

Mark Carroll BSc PhD Senior Lecturer in Biochemistry; Senior Tutor for Education Quality Dr Carroll’s interests are in biochemical education, educational quality and faculty development.

Vivien Cook BSc PGCE MA EdD Senior Lecturer in the Centre for Medical Education Dr Cook is an educationalist with interests in faculty development, work-based, non-formal learning and qualitative research methods. She teaches educational theory and practice within the MB BS programme and BSc in Medical Education.

Susan Dilly BSc MB BS FRCPath Professor Dilly joined Barts and The London in September 2006 as Director of the Institute for Health Sciences Education and Associate Dean for Undergraduate Medical Education. As an Honorary Consultant Histopathologist for Barts and The London NHS Trust, she specialises in perinatal pathology.

Sandra Eldridge MSc(Lond) PhD(Lond)

Christopher Griffiths MA DPhil(Oxon) FRCP(Edin) FRCGP

Professor of Biostatistics, Director of the UKCRC registered Pragmatic Clinical Trials Unit Professor Eldridge’s specific methodological research interests are in cluster randomised trials, and in modelling process data in pilot studies in order to inform the design of trials. Methodological work includes the largest systematic review of the methodology of empirical cluster randomised trials, and work on sample size calculations and internal and external validity of these trials. She is currently collaborating on a large number of pragmatic clinical trials including those concerned with the care of asthma, chronic obstructive pulmonary disease and angina. She also has a wider interest in the quantitative research methods used in primary health care and is a leading figure in the Royal Statistical Society primary health care study group, which provides a forum for those working in this area to exchange ideas about quantitative methods and learn from each other. She is on the editorial board of Family Practice.

Professor of Primary Care Professor Griffiths has been a General Practitioner in Hackney for twelve years and a Trustee of Asthma UK for three years. His main research interests are health inequalities and ethnicity, relating in particular to asthma, chronic obstructive pulmonary disease and tuberculosis. He currently serves on the development groups for NICE guidelines for type II diabetes and tuberculosis, and for the BTS/SIGN national asthma guidelines. He is an international editorial board member of the journals Thorax and the Primary Care Respiratory Journal.

Jon Fuller MB BS BSc FRCGP MHPEd Senior Lecturer in Medical Education, Centre Lead Dr Fuller is a General Practitioner in Hackney. He trained in medical education at Maastricht University, Netherlands. His interests include faculty development, teaching about education, developing educational quality and curriculum development.

Nicola Maffulli MD MS PhD FRCS(Orth) DipSportsMed Centre Lead and Professor of Sports and Exercise Medicine Professor Maffulli's continuing research interests are varied, and reflect his training in molecular biology, cardiovascular physiology, and musculo-skeletal medicine. The recent research thrust has been in the genetics of orthopaedic conditions, in tissue engineering of tendons, and mesenchimal stem cell therapy for tendinopathy. He performs clinical research on tendinopathy, and has carried out many randomized controlled trials in musculoskeletal medicine. During the years, Nicola has established a host of collaborations in the UK and abroad, and has lead multidisciplinary research teams in multicentre trials.

Barts and The London School of Medicine and Dentistry

Senior staff research interests Institute of Health Sciences Education

Adrian Martineau, B Med Sci DTM&H MRCP Clinical Lecturer in Centre for Health Sciences and also honorary research fellow in Division of Mycobacteriology at National Institute of Medical Research and Department of Medicine, Imperial College. Dr Martineau’s interests include immunomodulatory actions of vitamin D in respiratory infection, and pathogenic / protective role of neutrophils in tuberculosis. His work includes in vitro studies and clinical trials.

Dylan Morrissey PhD MSc MMACP MCSP Consultant Physiotherapist and Senior Clinical Lecturer in Sports and Exercise Medicine. Dr Morrissey combines clinical activity at Tower Hamlets and Barts and The London NHS trusts, with an academic role in the Centre for Sports and Exercise Medicine. His main research interest concerns the link between movement and pathology, with a number of studies ongoing in the newly re-equipped Human Performance Laboratory. Collaborators include groups at Queen Mary, Southampton University and King’s College London. Other research interests include the translation of evidence into clinical practice and optimal methods of inter-professional education. He runs the MSc sports injury assessment modules and is course lead for the intercalated BSc in SEM.

John Patterson BSc PhD Associate Dean for Undergraduate Medical Studies and Head of MB BS assessment Dr Patterson is responsible for MB BS degree regulations, assessment strategy and academic aspects of all MB BS assessments. His academic interests are in good assessment design (including assessment reliability) and standard setting methodologies. He is Barts and The London co-ordinator for a group of four UK medical schools piloting progress testing in association with the US National Board of Medical Examiners. Formerly he has been Chair of the University of London Extended Matching Question Bank

Clive Seale Professor of Medical Sociology, Lead for Human Science and Medical Ethics Professor Seale’s research interests include palliative and end-of-life care, communication in health care settings, the mass media, internet and health, and social research methods. His work involves the use of a variety of social research methods, including social surveys and different forms of qualitative data collection and analysis. He edits the journal Sociology of Health and Illness.

Stephanie Taylor MB BS Msc MD(Lond) Reader in Applied Research Dr Taylor is a part-time salaried General Practitioner and is also accredited in Public Health. Her

research interests include complex interventions for the management of chronic disease in the community with particular reference to heart failure, chronic obstructive pulmonary disease and chronic pain. Long-term involvement with a large longitudinal study of adolescent health in east London (www.relachs.org) has led to a research interest around adolescent overweight and obesity and its prevention. She has experience in the synthesis of research evidence, epidemiological field studies and clinical trials. She is an editorial board member (and deputy editor elect) for the journal Perspectives in Public Health (formerly Journal of the Royal Society of Health).

Barts and The London School of Medicine and Dentistry

Robert Walton BSc MD FRCP FRCGP DCH Professor of Primary Medical Care Professor Walton is a General Practitioner, his research interests are genetics and pharmacogenetics, smoking cessation and chronic liver disease. His work involves application of molecular medicine and novel diagnostic tests in Primary Care. He is currently investigating personalised treatments for tobacco addiction, performing studies on genetic aspects of therapy for tuberculosis and malaria and working on tests to identify those at high risk of complications from chronic viral hepatitis (hepatitis B and C) such as cirrhosis and liver cancer.

Olwyn Westwood BSc PhD(FIBMS; FHEA) Professor of Medical Education Professor Westwood has worked for around 20 years in medical education. She co-ordinated the set-up of the curriculum and its laboratories for the Graduate Entry Programme in Medicine at Swansea, then became the programme director. She has a keen interest in making the biosciences both accessible and relevant to medicine.

Patricia Revest BA PhD Senior lecturer in Medical Studies. Dr Revest joined the education section of the medical school in 2000 and is currently Head of the Year One MB BS. With an interest in E-learning Patricia Revest is also head of the SMD E-Learning Unit and leads on a number of E-

learning projects including IVIMEDS (International Virtual Medical School). She is author of a number of student textbooks including The Nervous System (Michael-Titus, Revest and Shortland, 2007) and Medical Sciences (ed. Naish, Revest and Syndercombe Court, 2009).

Michael Roberts MA(Med Ed) MD FCRP ILTHE Professor of Medical Education for Clinical Practice, Dean for Students and Head of Year five, Consultant Physician Whipps Cross University Hospital Professor Roberts’s clinical research interests include COPD and oxygen therapy. He is Associate Director of the Clinical Effectiveness and Evaluation unit of the Royal College of Physicians of London and leads the national COPD audit programme for the UK. Education research includes the transition from undergraduate to postgraduate medicine and Elearning. He is currently involved in research projects with the Department of Health and Liverpool University.

MRes in Medical Research One year full-time; two years part-time (Subject to approval)

Programme description This programme offers an opportunity to gain an excellent training in generic research skills. This is achieved through taught modules as well as conducting a

novel research project. On completion, you will be wellequipped to undertake a doctoral programme of study.

Programme outline Module options include: Governance framework and research management • Critical evaluation • Engagement with a wider audience • Presentation skills • Dissertation literature review

Assessment You will be assessed through a series of written and oral presentations including: Critical evaluation of a research method • Application to an ethics committee • Referees report of a paper and a grant proposal • Literature review • Proposal for a pilot study • Report of the pilot study (written, poster and oral presentations) • Fellowship proposal/grant application • Press release, topical article and oral presentation • Critical presentation of research papers

Entry requirements For entry on to the programme students will need either MB BS, BDS or a BSc with an upper second class honours in an appropriate subject.

Further information Professor Joy Hinson Tel: +44 (0)20 7882 2090 email: j.p.hinson@qmul.ac.uk

Barts and The London School of Medicine and Dentistry

Taught programmes Institute of Health Sciences Education

MSc/Postgraduate Diploma in Primary Care One year full-time, two years part-time Programme description This is a flexible, modular, multidisciplinary programme that aims to facilitate learning in topics that are meaningful to all primary care staff including GPs. It captures the rapid developments that are taking place in Primary Care, and is designed to provide new and exciting learning opportunities which will enhance your work experience. This programme is run jointly with City University and offers you a diverse range of routes. The one you choose to follow will depend on your career aspirations. You can either complete eight modules to attain the Postgraduate Diploma or continue to Masters level by submitting a 15,000 word dissertation. Modules can also be taken as ‘stand alone’ modules as part of your personal development plan, as required by the NHS knowledge and skills framework.

Programme outline The programme offers four routes: • Primary Care Route: a flexible route which allows students to choose from a wide range of options to meet their individual learning needs

• District Nursing Route

Entry requirements

• Long Term Conditions Route: particularly designed to meet the needs of those in community matron/case manager roles

The programme requires a suitable level of prior academic achievement and/or practical experience of delivering healthcare, either personally or in a managerial capacity. This can be shown by a medical, nursing or dental qualification of an appropriate standard, plus relevant professional experience. This can also be demonstrated by a good honours degree in another subject plus relevant professional experience. Applicants for a Masters Degree are usually required to have achieved an upper second class honours degree or equivalent standard in other qualifications. Applicants with other qualifications plus relevant experience, or without professional qualifications but with extensive relevant experience, will also be considered.

• Advanced Nurse Practitioner Route: RCN accredited route for those who wish to develop their skills as advanced practitioners For the full list of modules and route structures, please see the programme website: www.ihse.qmul.ac.uk/chs/ education/primarycare Each module includes 30 hours of group teaching. Students are also expected to spend 120 hours for each module on private study (reading, preparation for sessions, project work and assignments).

Assessment The programme consists of both formative and summative assessments. Students are required to complete an assessment at the end of each module. These include essays, presentations, reflective essays and an unseen written exam. In order to obtain the Masters award a 15,000 word dissertation must also be completed Students who have obtained the Postgraduate Diploma in Primary Care may convert this to a Masters degree by submission of the preparatory work and then the final dissertation, any time up to five years after starting the programme.

For language requirements, please see the international students section on page 133.

Further information Programme Administrator Tel: +44 (0)20 7882 2541 email: l.rope@qmul.ac.uk www.ihse.qmul.ac.uk/chs/courses/ primarycare

Barts and The London School of Medicine and Dentistry

One year full-time, two years part-time Programme description This programme is run jointly by Queen Mary, University of London and City University. This highly practical programme aims to enable you to develop the skills and knowledge to become a leader in public health, health economics or food policy and practice. By the end of the programme, you will also have the opportunity to cover the majority of the skills and knowledge required for the MFPHM part 1 examination. It offers students from a wide range of disciplines the opportunity to study practical aspects of public health with a strong emphasis on current public health issues, food policy or health economics.

Programme outline The programme offers four routes: • Public Health • Health Economics • Food Policy • Community Public Health Specialist Practice Nursing: Health Visiting; School Nursing; District Nursing For the full module list and route structures, please see the programme website:

Carol Rivas, PhD in Social and Cultural Contexts and Domestic Violence

‘‘

I’m looking at the effect that culture has on women’s responses to psychological abuse from a male partner. I am particularly interested in how women deal with their situation and how they manage their social identities when they stay within the relationship. I have interviewed Caribbean, African and white British women for the study. I think all three campuses are great for different reasons and it is nice that you can make use of the facilities at all three. The libraries are well resourced and there are libraries at each campus which is useful – you can return or renew at all of them interchangeably. I have found the staff to be nurturing and keen for me to get a good quality PhD. I work with some leading experts in my field who are very accessible and who also present great networking and other opportunities. There are great opportunities to mix at Queen Mary, from the personal development courses to curry nights, barbecues, special talks and so on. There is also a performance arts group, who sometimes provide free ‘theatre’ workshops and shows. The gym has a women only room. There are several good eateries both within and outside the college (some of them are of very high quality but still reasonably priced), and the canal and park at Mile End. The market at Whitechapel is vibrant and useful for bargains. I also help out with teaching, which I love, and taking children round the Centre of the Cell, which is the amazing new interactive exhibition at Whitechapel. I am also a science ambassador for schools, which means I go to special events for schools to promote science as a career. This might involve conducting mock job interviews, helping children do experiments or talking about my work. Last year I took children around the Big Bang, which also gave me the chance to enjoy it and have a go at everything.

‘‘

MSc/Postgraduate Diploma in Public Health

www.ihse.qmul.ac.uk/chs/ education/publichealth or http://www.city.ac.uk/study/ courses/communityhealth/publichealth-msc-pgdip.html

Each module includes 30 hours of group teaching and 120 hours private study for each module.

Barts and The London School of Medicine and Dentistry

Taught programmes Institute of Health Sciences Education

Assessment The MSc requires the completion of six core modules, two option modules and a dissertation. Option modules are taken from programmes at both City University and Queen Mary University. Diploma students will be required to complete eight modules only. Assessment varies per module and may include: essay writing, a policy paper or article suitable for submission for peer review publication, an oral or poster presentation of work, completing a reflective learning diary and completing a grant proposal form. Many or all the projects undertaken by students on this MSc will be closely related to your daily work.

Entry requirements We recognise professional experience from a wide range of relevant backgrounds in the public sector, with a minimum of two years’ professional experience for applicants together with at least a second class honours degree. International students need to have a degree-level qualification in an area related to public health, and equivalent professional experience.

Graduate profile: Dan Lewindon Studied: MSc in Sports Medicine, graduated 2007 Currently: I work full-time as Senior Physiotherapist for Northampton Saints RFC and as a locum physiotherapist for England RFU. Why did you choose Queen Mary? As a physiotherapist working in professional rugby, it was always my intention to complete an MSc in Sports Medicine both to improve my understanding and expertise in this rapidly evolving field. After much research I found Queen Mary to be the best programme for my needs. It offered the best mix of ‘foundation’ modules in assessment and injury management, and modules of interest and innovation, including team medicine, podiatry/ biomechanics and injection therapy. The flexibility of the programme also allowed me to limit time lost from work and spread the workload, which was essential in placating my employers. What did you gain from your time at Queen Mary? Although by no means easy and often requiring significant personal sacrifice, the MSc has been an extremely worthwhile experience for me, both with regard to my work within sport and also in general practice. It has improved the quality of my assessment skills and my ability to generate rehabilitation plans, which are criteria driven and evidence-based. I also gained an insight into the latest innovations in injury management and had the opportunity to network with leaders in the field of sports medicine, both lecturers on the programme and through organised shadowing sessions. I would whole-heartedly recommend this programme to any physiotherapist with an interest in sports medicine or an intention to work in the field. City University with supporting documentation.

Further information For language requirements, please see the international students section on page 133. Students in local PCTs may undertake this programme through the NHS London Commissioning Contract with

Caroline Humphrey Academic Administrator MSc Public Health, School of Community and Health Sciences City University, 20 Bartholomew Close, London EC1A 7QN

Tel: +44 (0)20 7040 5470 email: mscphad@city.ac.uk www.ihse.qmul.ac.uk/chs/courses/ publichealth

Barts and The London School of Medicine and Dentistry

MSc/Postgraduate Diploma in Sport and Exercise Medicine

Many of our alumni now work in both professional and amateur sport, 14 worked at Athens 2004 Olympic Games, and the Centre was involved for the bid for London 2012 Olympic Games.

One year full-time, two to four years part-time

Programme outline

Programme description This internationally renowned programme is open to doctors and physiotherapists. The programme is based on the philosophy of total care for the athlete and the promotion of physical activity in the general population. It is unique in the UK for the delivery of integrated academic and practical tuition. Based on the main Mile End Campus, the maximum intake is 30 students. Working in sport is a largely practical discipline and the emphasis on the programme is for regular clinical experience. Programme participants benefit from regular contact with members of the Centre as well as visiting clinicians and lecturers who are experienced sport medicine specialists. The Centre is ideally situated on the same campus as the sports injury, physiotherapy, podiatry and the interdisciplinary combined sports clinics. Additionally you will have the opportunity to attend recognised external clinics around London, as well as the chance to attend sporting events and visits to national centres of excellence where possible.

MSc Eight taught modules plus a research project (equivalent to four modules) Postgraduate Diploma Eight taught modules • Semester 1: September – December (12 weeks) five modules available • Semester 2: January – March (12 weeks) five modules available • MSc Research project: December – September Clinics: compulsory attendance of 32 clinics

Modules Sports Injury Assessment I • Sports Injury Assessment II • Sports Injury Treatment • Sports Injury Rehabilitation • Exercise as a Health Tool • Podiatry and Biomechanics • Medical Problems in Sport • Exercise Physiology and Team Medicine • Injection of the Spine and Appendicular Skeleton • Research Methods

Assessment Taught modules are assessed by a variety of written exams, coursework and clinical exams. All are weighted in varying

degrees, the dissertation accounts for one third of the total marks.

Entry requirements Doctors and physiotherapists with at least one year’s postgraduate relevant clinical experience. Current involvement with sport would be an advantage. Physiotherapists with overseas qualifications must be registered with the Health Professions Council. For language requirements, please see the international students section on page 133.

Further information Dr Peter Malliaras Tel: +44 (0)20 8223 8255 email: p.malliaras@qmul.ac.uk www.smd.qmul.ac.uk/sportsmed

William Harvey Research Institute

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William Harvey Research Institute www.whri.qmul.ac.uk

Director of Institute Professor Mark Caulfield email: m.j.caulfield@qmul.ac.uk

Our new state-of-the-art laboratories host seven distinct centres:

Director of Graduate Studies

• ARC Bone and Joint Research Unit

Dr Martin Carrier email: m.j.carrier@qmul.ac.uk

• Biochemical Pharmacology • Clinical Pharmacology

Key research areas The William Harvey Research Institute has just celebrated its twenty-fifth year with real success and growth in the depth and quality of our programmes in cardiovascular, inflammation and endocrine research. Our major strength is in bringing scientists with different skills together. Our goal is to combine disciplines, such as genetics, cell biology, pharmacology, epidemiology, advanced imaging and clinical trials, with therapeutic innovation. Recently we have strategically invested over £4.1 million in excellent researchers to support our mission and increased staff by 24 per cent. This Institute was established by the Nobel Laureate Sir John Vane in 1985, and is named after William Harvey who revolutionised medicine by the discovery of the circulation of blood. The core aims of the research in the institute are: to study the causes, mechanisms and therapy of endocrine disease; to advance knowledge as a basis for the identification of new therapies to prevent heart and vascular and inflammatory disease and to treat rheumatoid arthritis, renal disease and the many complications of diabetes.

• Endocrinology • Experimental Medicine and Rheumatology • Microvascular Research • Translational Medicine and Therapeutics The Centres are organised in a flexible manner so as to promote, and assure maximal interaction and cross-fertilisation. We foresee that the future of modern biomedical science will inevitably progress through exchange of ideas, tools, models and systems and benefit from teamwork and a multi-disciplinary approach. The physical structures of the laboratories, complemented by the shared interests across the centres, guarantee the implementation of this vision. The aim of the centres is to create an integrated and focused Pharmacological Research Group based at the Charterhouse Campus. The research strategy is to fully integrate the basic and clinical research. The aim is to develop the largest centre for heart disease research in Europe, and to develop a cardiovascular research centre that will complement the planned coalescence of clinical cardiac

services at St Bartholomew’s Hospital. Similarly the Academic Department of Rheumatology interlinks with the clinical service and supervises the widely praised SPR training programmes. This is further enhanced by the clinical research programmes, enabling links between the clinical department and Centres within the Charterhouse campus, and with other researchers within the Inflammation Research theme. These key clinical partnerships ensure our scientists remain strongly connected to the patient and the disease process. In addition a brand new 3000m2, £14 million heart research centre is due to open later in 2010.

ARC Bone and Joint Research Unit This Unit consists of a multidisciplinary faculty of scientists and clinicians interested in the basic molecular mechanisms of autoimmune diseases and connective disorders, including rheumatoid arthritis and systemic lupus erythematosus. Research in the Unit is aimed at developing new gene therapy tools and approaches with stem cells for delivering therapeutics and repair sites of chronic disease, with a major, but not exclusive, attention to the rheumatic joint, and to develop gene delivery methods for treatment. Other research activities include: signalling cascades in T cells and the molecules that are found on lipid rafts and how this surface

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William Harvey Research Institute

membrane localisation affects cell function; research devoted to understanding the role that B lymphocytes play in systemic lupus erythematosus and other rheumatic diseases; using phage display technology, human monoclonal antibodies have been developed that specifically bind to arthritic cartilage and can be used for targeting therapeutic agents or cells only to arthritic joints. A wide range of possible therapeutic targets is being investigated. Work in the group has already demonstrated a therapeutic effect of interferon in a model of rheumatoid arthritis.

Biochemical Pharmacology Centre The research emphasis here is on the control of inflammatory and immune diseases and mechanisms of immunomodulatory and anti-inflammatory drug action (such as Cox-2 inhibitors and glucocorticoids). Of particular interest to the Centre are the nature and function of endogenous regulators that mitigate and control the inflammatory response and (normally) bring about its timely resolution. We have pioneered the notion that malfunction of endogenous counter-regulatory pathways may precipitate or prolong inflammation and that it may be a causal factor in chronic human inflammatory disease is being actively investigated. We seek to generate novel drugs basing targets on the properties of

such counter-regulatory factors. Work in this group has also defined the role of the protein annexin A1 in inflammation and other disorders; research has shown that it acts to regulate the flux of leucocytes during inflammation. The Centre utilises techniques spanning in vivo and in vitro approaches including molecular biology, transgenic models, experimental pathology, cell biology and human pharmacology of anti-inflammatories.

Centre for Experimental Medicine and Rheumatology Research activities focus on the development of innovative therapeutic and diagnostic approaches to inflammatory arthropathies, particularly rheumatoid arthritis. Thus, research goals in this Centre is in full synergy with that of the ARC Bone and Joint Unit and Biochemical Pharmacology, contributing to an overall critical mass of 80 clinicians and scientists dedicated to inflammation research, regenerative medicine, and rheumatology. The emphasis is on translational research by combining strengths and expertise of basic and clinician scientists, The main research themes include: Molecular mechanisms of tissue specific homing, chemokines and cytokines in cell migration and joint damage; the pathobiology of synovitis: relationship to clinical

phenotypes, biological and disease outcomes. Why do only a proportion of patients that present early inflammatory arthritis carry on developing rheumatoid arthritis; target discovery, drug delivery, imaging and proof of concept/efficacy studies using platform technologies based on phage display and the human/SCID mouse transplantation model, biological joint tissue repair developing molecular and stem cell based therapies for joint tissue repair. The development of a quality controlled cellular product for cell-based joint surface repair (currently being tested in a phase 3, multicentre randomised clinical trial) is a major result. This research programme merges well with other on-going high quality research projects on Stem Cells of our Medical School.

Centre for Translational Medicine and Therapeutics The Centre for Translational Medicine and Therapeutics was created by merging three distinct units. This Centre reflects the new spirit pervading the WHRI, and the strong commitment to sharing facilities, ideas and research projects, with synergistic outcomes. Common research themes evolve around vascular biology, endothelial dysfunction and preservation or restoration of organ integrity. More specifically the centre aims to: Develop novel approaches for the therapy of myocardial infarction, acute and chronic renal failure and shock; to understand the ways in which

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both endothelial and vascular smooth muscle cell functions within the blood vessel change following exposure to proinflammatory stimuli such as cytokines and free radicals. The centre also has a major interest in the experimental and clinical development of biomarkers that could become novel diagnostic tools. Techniques spanning from complex in vivo protocols to in vitro approaches including molecular biology, transgenic models, cell biology and human pharmacology to clinical trials.

and the biological atlas of insulin resistance. As genetic studies are beginning to progress to an integrative biology approach we are developing a strong interest in Proteomic Medicine to facilitate development of cardiovascular proteomics and metabonomics.

Centre for Clinical Pharmacology

A further major area of interest is research into new mechanisms underlying the protective actions of the endothelium; which includes nitric oxide and

The William Harvey Research Institute offers one of the largest Centres for Clinical Pharmacology in the UK. Our research strategy combines basic science; ranging from vascular biology, genomic approaches and large-scale genetic epidemiology to innovative clinical trials as a route to potential new therapies for cardiovascular disease, prevention of transplant rejection and pain management. The major research themes are summarised below: Molecular genetics of cardiovascular disease, from Clinical Pharmacology we coordinate the MRC British Genetics of Hypertension (BRIGHT) Study on behalf of five other UK universities. This collaborative programme has assembled a high quality repository for the investigation of the genetic basis of hypertension. Other studies include Genetics of pre-eclampsia

Identification of positional and functional candidate genes for coronary artery disease; an important observation being on the role of genes encoding matrix metalloproteinases in atherosclerosis.

endothelium derived hyperpolarising factor.

Centre for Microvascular Research The overall research objectives of this centre are to investigate molecular and cellular events within the microvasculature, focusing on mechanisms associated with leukocyte trafficking, vascular permeability and regulation of vascular integrity, morphology and function, in vivo. The principal approach employed is that of cutting edge imaging methodologies, in particular real-time imaging of the microcirculation using fluorescent and confocal microscopy.

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William Harvey Research Institute

Centre for Endocrinology The group’s research is underpinned by an internationally renowned expertise in adult and paediatric clinical endocrinology. Research activity in this Centre spans the range between clinically applied research in endocrinology to basic research in endocrine signalling pathways. Clinical research benefits from the extensive clinical endocrinology experience and the national and international referral practice for complex endocrine disorders that has accumulated in over forty years as the UK’s foremost clinical endocrinology unit. Endocrinology research benefits from considerable cross-fertilisation between clinical and laboratory research components.

Molecular Endocrinology Research themes include growth disorders in infancy and childhood. This theme builds on the extensive clinical practice in the diagnosis and management of growth hormone (GH) insensitivity which has led to identification of several novel genetic mechanisms; studies into the biological function of the peptide ghrelin and in particular its role in growth and obesity; mechanism of ACTH action via the ACTH receptor and its disturbance in ACTH insensitivity; molecular basis of pituitary and other neuroendocrine tumour formation, building on longstanding clinical experience of the diagnosis and management of these tumours; mechanisms regulating gene

expression in pituitary gonadotroph, bone and other cells. Recent research exploits modern molecular and cell biological technology to investigate aspects of functional physiological genomics and genetics as applied to the hormone producing and hormone sensitive tissues.

studies in collaboration with the pharmaceutical industry. We have access to all the latest assays and diagnostic ‘hardware’, but most importantly our ever-expanding patient base is now truly international. We have a dedicated and fully staffed investigation unit with 16 inpatient beds available for the study and treatment of all types of endocrine disease.

Clinical Endocrinology As the largest centre for clinical endocrinology in the United Kingdom, a wealth of clinical data and expertise supports research in several areas. It has been at the forefront internationally in terms of the assessment of new diagnostic and treatment modalities in endocrinology generally, and more specifically in neuroendocrinolgy and endocrine oncology. More recently, clinical investigation has centred on the value and effects of GH deficiency in pituitary disease, and we have one of the largest groups of patients in the world on GH replacement therapy. On-going protocols include assessments of novel types of testosterone replacement therapy, an assessment of the optimal diagnostic strategies for Conn's syndrome and hyperparathyroidism, the use of somatostatin analogues in nonfunctioning neureoendocrine maligancy, and the treatment of osteoporosis in Cushing's disease. Many of these studies are initiated ‘in-house’, but we have an established expanding portfolio of

Barts and The London Genome Centre This is a state-of-the-art high throughput genome centre embedded within the William Harvey Research Institute. The Centre provides technologies to support scientists, which include whole genome gene expression service, fully automated quantitative gene expression service, SNP genotyping, DNA sequencing from PCR and Plasmid templates and automated DNA quantification.

Barts and The London Mass Spectrometry Unit This facility offer state-of-the-art MALDI-TOF and LC-MS/MS instruments for a wide range of protein analyses. These include protein identification from 1D or 2D gels, identification of posttranslational modifications such as phosphorylation and determination of intact protein mass. The Unit provides support for collaborative research and we are currently working with researchers

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in cardiovascular disease research projects including hypertension, left ventricular hypertrophy and endothelial dysfunction, as well as other research areas such as fertility and cancer.

The William Harvey Research Foundation The William Harvey Research Foundation (WHRF) has been a member of the Association of Medical Research Charities since 1990. The Foundation supports research primarily in the WHRI. The Foundation also plays a key role in funding the training of young medical researchers through PhD and Masters of Research Studentships.

William Harvey Research Limited William Harvey Research Limited was established in 1990 to facilitate interaction between

academia and the pharmaceutical industry. Scientific personnel of the WHRI provide the foundation of experience and expertise to complement drug development for pharmaceutical and biotech companies.

Opportunities at WHRI WHRI Research Graduate Studies Training The Institute provides a wide range of PhD, MD (Res) and Masters training under the auspices of the Graduate School. More information can be obtained by contacting the Postgraduate Research Tutor who will ensure your request is appropriately dealt with.

WHRI Mentoring, Tenure track Our approach to mentoring clinicians and scientists includes strong encouragement for people to recognise when their research

training would benefit from a period in another research institution so they may accrue new strengths and to return to senior positions if they wish in the future. This approach which initiated the careers of most of the WHRI Principal Investigators is still very active. Clinical Academic career development The WHRI is committed to developing high cadre national and international clinical researchers and we are closely engaged through academic clinicians to cardiology, nephrology, endocrinology and rheumatology in our allied NHS Trust. We actively encourage and support undergraduate and postgraduate clinicians to engage in our research projects and garner pilot data for fellowship applications. William Harvey Annual Research Review The WHRI believes in encouraging and investing in people who will contribute here and elsewhere to international quality research. As part of this strategy we hold the William Harvey Annual Research Review where the strategic direction of the School and Institute is articulated by senior academic staff, but the majority of time is for more junior researchers and PhD students to showcase their research. The William Harvey holds weekly seminars by national and international experts.

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Senior staff research interests William Harvey Research Institute

Amrita Ahluwalia BSc PhD Professor of Vascular Pharmacology Professor Ahluwalia's work focuses on mechanisms of vascular homeostasis in inflammation and particularly the role of the endothelium, also in the identification of novel mediators protecting against vascular dysfunction. Endothelium-derived vasodilators

including nitric oxide, prostacyclin and endothelium-derived hyperpolarising factor (EDHF) play a key role in these processes. Professor Ahluwaliaâ&#x20AC;&#x2122;s recent work has further highlighted the importance of these mediators and mechanisms which coordinate their bioactivity to optimise the cytoprotective effects of the endothelium. In particular her studies have provided further

insight into the gender difference (together with Dr Ramona Scotland) in cardiovascular disease, with EDHF appearing to play a prominent role in conferring a cytoprotective phenotype in females, an effect likely mediated by oestrogen. In a separate study we have shown that eNOS can act in both a proand anti- inflammatory manner and therefore is likely to be pivotal in the initiation and timecourse of an inflammatory response, particularly with respect to inflammatory cardiovascular disorders such as sepsis. Other recent work has identified the acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate.

Jacky Burrin BSc PhD FRCPath Professor of Experimental Endocrinology Professor Burrinâ&#x20AC;&#x2122;s main research interests focus on the hormonal regulation of gene expression, particularly investigation of the role of transcription factors (SF-1, DAX-1, GATA) in the differentiation of pituitary cell types and peptide-regulated hormone gene transcription and their relevance to pituitary tumour pathogenesis. The role of BMPs in this system is currently under investigation (funded by the BBSRC). This work links with research into nuclear hormone receptors (LXR and PPARs) mediating BMP actions on osteoblast differentiation and the role of glucocorticoids in inhibition of osteoblast proliferation. Investigation of the

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signal transduction pathways involved in both systems, particularly MAPK signalling, is integral to this research.

Mark Caulfield MB BS MD FRCP Professor of Clinical Pharmacology, Institute Director and Centre lead Clinical Pharmacology Mark Caulfield graduated in Medicine in 1984 from The London Hospital Medical College and trained in Clinical Pharmacology at St Bartholomew’s Hospital where he developed a research programme in molecular genetics of hypertension. From 1996 he has been National Co-ordinator of the MRC British Genetics of Hypertension (BRIGHT) Study on behalf of five UK Universities www.brightstudy.ac.uk. Our purpose-built clinical research facility the William Harvey Research Institute played a key part in the Anglo-Scandinavian Cardiac Outcome Trial recruiting 1,157 hypertensives (www.ascotstudy.org.uk). This trial has changed international guidance on lipid lowering and blood pressure. In 2000 he successfully bid for £3.1 million to create the Barts and The London Genome Centre, which now underpins over 40 programmes of research. He was appointed Director of William Harvey Research Institute in 2002. Other current research interests include: Principal investigator of the Genetics of Pre-eclampsia

Consortium – which has identified 1,000 families with pregnancyrelated hypertension for genetic studies; Co-grant holders with Imperial, Cambridge and Oxford for the Biological Atlas of Insulin Resistance to develop observations on metabolic syndrome and translate these from experimental models to man; Deputy Chair, The London Biobank regional collaborating centre, Chair of Biobank UK ethnicity sub-group and a member of Biobank UK measurement sub-group.

Yuti Chernajovsky BSc MSc PhD ARC Professor of Rheumatology, Centre Lead of the Bone and Joint Research Unit Professor Chernajovsky trained as a molecular biologist at The Weizmann Institute of Science in Israel. His research activities have included the cloning of several interferons, interleukins and their receptors. He has contributed to the cloning and development of interferon beta as a therapeutic agent and the use of suicidal genes for cancer gene therapy. Current research interests include the development of gene transfer strategies for the treatment of rheumatoid arthritis via cellular engineering, molecular design and genetic engineering. He is a member of the editorial boards of the British Journal of Pharmacology, Gene Therapy and Arthritis Research and Therapy.

Shern Chew BSc MB BChir MD FRCP Professor of Endocrine Medicine Dr Chew’s research investigates the mechanisms of regulation of pre-mRNA splicing with clinical research in clinical endocrinology. This research is funded by fellowships from the Wellcome Trust.

Adrian Clark DSc FRCP FMedSci Professor of Medicine, Centre Lead Endocrinology Professor Clark’s major research focus is on the molecular basis of the action of the pituitary hormone ACTH and its role in the pituitary-adrenal axis in health and disease. The group have demonstrated the role of ACTH receptor defects in inherited syndromes of ACTH insensitivity which have led to a detailed investigation of the functional biology of this receptor. Defects in a newly discovered gene that appears to function as a receptor chaperone have recently been described, providing major new insights into receptor function. In addition, a longstanding interest in growth hormone insensitivity in conjunction with Professor Martin Savage has resulted in the identification of several growth hormone receptor mutations that lead to novel mechanisms of receptor impairment, and to the only human case of IGF-I gene deletion. A prospective study of multiple candidate genes in affected patient-parent trios is being pursued in the NESTEGG study, a large cross-European collaborative programme. A

Barts and The London School of Medicine and Dentistry

Senior staff research interests William Harvey Research Institute

further interest focuses specifically on mechanisms that lead to hypertension and insulin resistance.

Roger Corder BSc MSc PhD MRPharmS Professor of Experimental Therapeutics Professor Corder’s main research interests are the links between diabetes and atherosclerosis. This research has essentially two goals. Firstly, to discover new therapeutic approaches that can be used to prevent this everincreasing health problem. Secondly, to identify biomarkers of disease, which can be used in the early diagnosis of patients before symptoms of disease become apparent. These interests have also led him to investigate the importance of improving health and cardiovascular well-being through diet. During the past five years he has studied the mechanisms underlying the beneficial effects of regular red wine consumption. He is also pursuing research on alternatives to wine, such as grape seed extract, as these are more amenable to conducting clinical trials. This research is providing a wealth of new insights into how polyphenol-rich diets can modify vascular well-being. Professor Corder is currently supervising students investigating the mechanism of action of polyphenols on vascular function, biomarkers of vascular disease in diabetes, and regulation of gluconeogenesis in type 2 diabetes.

Rod Flower FRS BSc PhD DSc Professor of Biochemical Pharmacology and joint Centre Lead, Biochemical Pharmacology Rod Flower is a Wellcome Trust Principal Fellow and Professor of Biochemical Pharmacology. Throughout his life he has researched the mechanisms of anti-inflammatory drugs and has a particular interest in NSAIDs and glucocorticoids. His current interests include the pharmacology of annexin 1 and its relationship to glucocorticoid action in host defence and the neuroendocrine system. Rod Flower was formerly President of the British Pharmacological Society and is a Fellow of the Academy of Medical Sciences and The Royal Society.

Ashley Grossman BA BSc MD FRCP FMedSci Professor of Neuroendocrinology In addition to clinical work in neuroendocrinology and endocrine oncology, Professor Grossman runs a research group in translational research. His major clinical interest is in optimising diagnostic techniques and therapeutic modalities in pituitary and neuroendocrine tumours. His major basic research over the past years has been into the hypothalamic control of pituitary function, and particularly the role of cytokines and gaseous neurotransmitters in regulating the pituitary-adrenal axis. More recently, he has focused on the molecular pathogenesis of pituitary tumours, specifically on

abnormalities in cell cycle and cell signalling pathways, using pathological human material and as well as cell culture techniques. Much of this work has been carried out in collaboration with Dr Márta Korbonits, and increasingly the control of metabolic processes by ghrelin and related peptides has been shown to interact with the regulation of cell proliferation.

Charles Hinds FRCP FRCA Professor of Experimental Medicine Professor Hinds is a past President of the Intensive Care Society and until recently was Chairman of Examiners for the UK Diploma of Intensive Care. He is UK representative on the Council of the European Society of Intensive Care Medicine, a member of the Education and Training Subcommittee of the ESICM and UK co-ordinator for the European Diploma of Intensive Care Medicine. Professor Hinds’ research interests have included the pathophysiology and treatment of sepsis, ‘goal directed’ therapy, endocrine aspects of critical illness, critical illness polyneuromyopathy and intensive care for patients with malignancy. More recently he has developed an interest in the genomics of sepsis and has helped to establish the UK Critical Care Genomics Group which is undertaking a large National investigation (GAinS – www.ukccg-gains.org), as well as being National co-ordinator for

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Staff profile: Sussan Nourshagh Professor of Microvascular Pharmacology Centre for Microvascular Research

‘‘

I was appointed Professor of Microvascular Pharmacology at the William Harvey Research Institute to head a new Centre focusing on Microvascular Research. My research group focuses on the mechanisms of leukocyte trafficking into sites of inflammation and the consequence of this response on regulating the phenotype of emigrated cells. The group’s principal experimental approach is the use of advanced imaging techniques (eg intravital and confocal microscopy) for analysis of leukocyte/vessel wall interaction in vivo. Our work is supported by The Wellcome Trust, The British Heart Foundation and funds from the EU and has been published in high ranking journals such as Journal of Immunology, Blood, Journal of Experimental Medicine, Nature Reviews and Science. My PhD project addressed mechanisms of neutrophil activation in vitro, and I extended my interests in this area to the in vivo inflammatory scenario through post-doctoral work at the MRC Clinical Research Centre based in Harrow, and then at the National Heart & Lung Institute (NHLI) in London where I was appointed to Lecturer position in 1988. In 2001, I was awarded the Quintiles Prize for outstanding contribution to Immunopharmacology and became Fellow of the British Pharmacological Society in 2005. I have acted as a committee member on the British Heart Foundation Project Grant panel (2002-2006), was a co-founder and committee member of the London Vascular Biology Forum (2001-2008) and am currently the Treasurer of the UK Adhesion Society and Programme & Fellowship Committee member for the American Society of Investigative Pathology (ASIP).

the European ‘GenOSept’ study (www.esicm.org). Other current research interests include the use of a nitric oxide generating mixture to prevent ventilator associated pneumonia and perioperative optimisation for patients undergoing high risk surgery.

Paul Jenkins MA BChir MD FRCP Reader in Endocrine Oncology Dr Jenkins’ research has centred on understanding the influence of growth hormone and insulin-like growth factor-I (IGF-I) on the bowel and in particular their role in colorectal cancer. This has been facilitated by the study of patients with acromegaly, of which more than 400 are looked after by this Department. Recent research has confirmed that these patients are at increased risk of developing colonic polyps and cancer, and is being undertaken to understand the mechanisms by which this might occur. The work will span the investigation of basic molecular pathways to their involvement in the clinical situation with the eventual aim being to modify these and thus alter clinical care. The other major area of interest is growth hormone and exercise and the detection of growth hormone doping by athletes, which is an area of increasing concern to sports governing authorities.

‘‘

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Senior staff research interests William Harvey Research Institute

Atholl Johnston BSc MSc PhD FBPharmacolS FRCPath Professor of Clinical Pharmacology Professor Johnston has over 30 years experience in the measurement of drug concentrations as a guide to therapy and in relation to toxicity. His research interests are in clinical trial design and statistical data analysis, modelling pharmacokinetics and pharmacodynamics, and in optimal use of immunosuppressive, cardiovascular, analgesic and anti-cancer drugs. Potential mechanisms for these differences have been explored further by detailed examinations of the pharmacogenetics determinants of the metabolism of immunosuppressant drugs. Professor Johnston has

contributed to international consensus papers on the optimal use of ciclosporin in psoriasis, ciclosporin monitoring, ciclosporin generic substitution and its potential impact on transplant outcome. Professor Johnston has a commitment to continuing education. He has already initiated Masters courses in clinical drug development and in healthcare research and with Professor Peter Vanezis has developed a modular course in forensic medical sciences.

Mรกrta Korbonits MD PhD Professor of Endocrinology and Metabolism Professor Korbonits studies the hormonal regulation of the cellular energy sensor AMP-dependent protein kinase (AMPK) in particular regarding ghrelin and cannabinoids. Her current interest

in pituitary disease is focused on familial pituitary adenomas. Key objectives are: Ghrelin and cannabinoids stimulate hypothalamic and heart AMPK activity but in contrast, they inhibit AMPK activity in liver and adipose tissue. Ghrelin and cannabinoid pathways are potential targets for obesity treatment. We have shown a direct interaction between ghrelin and cannabinoids. Further investigations of the relationship will improve the understanding of the underlying mechanism of energy homeostasis; Familial pituitary adenomas are rare but increasingly recognised. Professor Korbonits in collaboration with UK and international colleagues has collected a large cohort of familial pituitary adenoma families and studies the clinical characteristics as well as the genetic and functional basis of the alterations

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of the gene, the AIP gene, mutated in a significant minority of this cohort. She is working closely with Professor Grossman in topics related to cell cycle regulation and endocrine tumorigenesis especially in the pituitary gland.

Richard Langford MB BS MRCS LRCP FRCA Professor of Inflammation Science Professor Langford’s current research interests include acute and chronic pain studies. He has established the Pain Research Group, which now has eleven fulltime research staff conducting clinical trials; development and evaluation of patient monitoring devices, including opto-electrical photoplethysmography, and depth of anaesthesia / cerebral monitoring during surgery and intensive care.

Rizgar Mageed BPharm PhD Professor of Experimental Immunology Professor Mageed’s interests are focused on defining the cellular and genetic factors that underlie the development of immunemediated diseases. Early studies examined the genetic basis that underpins defective lymphocyte activity leading to the production of pathogenic autoantibodies in patients with chronic inflammatory diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). These studies have indicated that lymphocytes from patients with RA and SLE are inherently hyper active. Current studies are

aimed at defining the precise intracellular biochemical signalling defects that cause lymphocyte hyper activity including dysregulated responses to self antigens. These studies will provide insights into how lymphocytes are regulated and how intracellular biochemical signalling pathways determine whether there is homeostasis or autoimmune disease. Some of this data is being used to design new therapeutic targets by gene therapy. Professor Mageed has published numerous scientific papers on the molecular basis of susceptibility to RA and SLE.

date looking at the role of stem cells in cardiac repair for patients with heart failure.

Anthony Mathur MA MB BChir MRCP PhD

Professor of Microvascular Pharmacology Professor Nourshargh’s interests are in the mechanisms of leukocyte trafficking into sites of inflammation and the consequence of this response on regulating the phenotype of emigrated cells. Her key objectives include: Dissecting the molecular and cellular interactions that mediate leukocyte transmigration through venular walls, investigating the mechanisms associated with leukocyte emigration through endothelial cells, pericytes and the EC basement membrane. Analyse and characterise the consequences of leukocyte transmigration on regulation of expression of effector molecules and regulation of leukocyte responsiveness under different inflammatory scenarios. Mechanisms of leukocyte transmigration in specific disease

Senior Lecturer and Consultant Cardiologist Dr Mathur divides his time equally between clinical work and basic science with the aim of conducting translational research. Key interests are directed at understanding the role of cell therapy in the treatment of cardiovascular disease. This covers a broad spectrum of research ranging from a study of the mechanism by which cell therapy may improve cardiac function to optimisation of cell therapies to ultimately produce cardiac regeneration. Clinical research is directed at new treatments for the 'no-option' patient - that is people who have cardiac disease and no further conventional treatments available to treat on-going symptoms. Dr Mathur is the chief investigator of one of the largest clinical trials to

Patricia Munroe BSc MSc PhD Professor of Molecular Medicine Professor Munroe’s research is focused on determining the molecular basis of essential hypertension. With Professor Mark Caulfield, she co-ordinates the British Genetics of Hypertension (BRIGHT) study on behalf of five other UK universities (Aberdeen, Cambridge, Glasgow, Leicester and Oxford).

Sussan Nourshargh PhD FBPharmacolS

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Senior staff research interests William Harvey Research Institute

models, to investigate the above fundamental phenomena in both physiological inflammatory scenarios and experimental models of disease, such as models of ischemia/reperfusion injury and vasculitis.

David Perrett BSc PhD FRSC CChem Professor of Bioanalytical Science Research interests extend to many biomedical aspects of separation science having been one of the first researchers in Britain to develop and use HPLC (1972). Since 1989 bioanalytical research interests have included extensive studies on the application of capillary electrophoresis (CE) to biological and clinical samples. Current interests extend these older interests into proteomics, metabolomics and mass

spectrometry. Research interests include clinical proteomics, free radical damage to proteins and multidimensional chromatography. Much current research work relates to the decontamination of surgical instruments in relation to vCJD. In 2002 he was awarded the Jubilee Medal of the Chromatographic Society cited for the Development of Separation Science in Biomedicine and Clinical Chemistry. He is an elected member of the Council of Analytical Division of the RSC, the Council of the British Society of Proteome Research. He has also chaired the Techniques Group of the Biochemical Society and the Chromatography and Electrophoresis Group of the RSC. He serves on two Department of Health committees on decontamination.

Mauro Perretti BSc MSc PhD FBPharmacolS Professor of Immunopharmacology, Senior Research Fellow of the Arthritis Research Campaign, joint Centre Lead Biochemical Pharmacology Professor Perrettiâ&#x20AC;&#x2122;s work focuses on the investigation of the endogenous mediators that actively promote resolution of inflammation and regain of tissue homeostasis. To regain health after an inflammatory insult, the host must organise a proper inflammatory response, which however, should result from an appropriate temporal and spatial balance between endogenous proinflammatory and antiinflammatory mediators and pathways. The group studies specific elements of this endogenous response, focusing on selected mediators and receptors. Therefore, on one hand the patho-physiological relevance of these mediators in models of acute (air-pouch, peritonitis) and chronic inflammation (eg arthritis, endotoxaemia) is determined using a combination of molecular, cellular and integrate biology approaches (eg transgenic tools); on the other hand, an equally important ethos of this research is the identification of the target(s) mediating the effects of endogenous anti-inflammation as a lead for innovative drug discovery: these new therapeutics will potentially produce much less side effects, since they will be mimicking the way our body naturally controls the inflammatory reaction.

Barts and The London School of Medicine and Dentistry

Costantino Pitzalis MD PhD MRCP Professor of Experimental Medicine and Rheumatology, Centre lead Experimental Medicine and Rheumatology Professor Pitzalis’s main research activities focus on the development of innovative therapeutic and diagnostic approaches to inflammatory and degenerative arthropathies, particularly rheumatoid and osteoarthritis. Specific research areas include: Molecular mechanisms of tissue specific homing, chemokines and cytokines in cell migration and joint damage. Applying a phage display technology to the SCID model we have identified novel peptide sequences endowed with specific homing to human rheumatoid synovium. We are also exploiting the use of these sequences for developing tissue-specific imaging and drug delivery systems, thereby targeting anti-rheumatic drugs as well as new treatments to the joint: The pathobiology of synovitis and the relationship to clinical phenotypes, biological and disease outcomes. This is an important area of research with the likelihood of high translational impact. This programme aims to characterise clinical phenotypes pathobiologically in order to identify markers that can tailor aggressive treatment to patients with poor prognosis thereby improving longitudinal disease outcomes. We have developed a chimeric model in which cell homing to human tissue transplanted onto SCID mice can

be studied, both for pathway characterisation (eg trafficking mechanisms), target identification (eg specific chemokine receptors) as well as dissecting immuneinflammatory pathogenetic mechanisms for novel therapeutic development. The latter aspect is extremely important and novel, since it enables us to investigate the efficacy of potential therapeutics on human cells and human tissues (for example rheumatoid synovium) such that drug effectiveness is likely to have translational value.

patients from London, Rotterdam, Toulouse and Tübingen, will study candidate genes for linkage of SNPs with phenotypic variants in idiopathic short stature and children born SGA. We currently have a database of 46 patients with paediatric Cushing’s syndrome. Patients are referred from the UK, Europe and beyond. Characteristics of 30 patients with Cushing’s disease have been recently published. We collaborate closely with the Department of Adult Endocrinology, Neurosurgery and Radiotherapy.

Martin Savage MA MB FRCP FRCPCH

Ken Suzuki MD PhD

Unit head and Professor of Paediatric Endocrinology The principal interests of the unit are; the molecular and endocrine characterisation of disorders of the GH-IGF-I axis, treatment of GH resistance with the recombinant IGF-I/IGFBP-3 complex, growth genetics and the investigation and treatment of paediatric Cushing’s syndrome. There is close collaboration with Professor Adrian Clark’s laboratory, where identification of several new mutations of the GHIGF-I axis have been demonstrated. We are currently co-ordinating a pivotal therapeutic trial of the recombinant IGF-IIGFBP-3 complex (Insmed Inc) in patients with GH insensitivity syndrome. The NESTEGG project (Network for the study of genes in growth) is directed by Adrian Clark and co-ordinated by Linda Johnston. This project, which unites populations of short stature

Professor of Translational Cardiovascular Therapeutics Professor Suzuki has an international reputation in cardiovascular stem cell and gene therapy research. His extensive expertise will strongly complement our on-going clinical programme at Barts and The London (led by Dr Anthony Mathur and Professor Martin Rothman) to evaluate an emerging strategy using adult stem cells for treating heart diseases and thus significantly contributing to the establishment of a Centre of Excellence in clinical stem cell research which is underpinned by strong basic science programmes. His research approach acknowledges that the success of clinical trials of cell therapy critically depend on resolving several fundamental issues by further laboratory research. His research programme has focused upon various aspects of behaviour of grafted cells in a cardiac

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Senior staff research interests William Harvey Research Institute

environment and interaction between native and grafted cells at genetic, molecular and cellular levels. Suzuki is now focusing on studying, and therapeutically controlling arrhythmias after cell therapy. Current research projects evolves around the study of cardiac side population cells, transendothelial migration of donor cells into the myocardial interstitium and the role of inflammatory response in cell therapy-mediated therapeutic effect, the latter clearly of potential synergy with other labs of our Institute.

Chris Thiemermann MD PhD FBPharmacolS FMedSci Professor of Pharmacology, Centre lead Translational Medicine and Therapeutics Professor Thiemermann is a leading expert in the pathophysiology and therapy of myocardial infarction, renal failure and shock. He holds Visiting Professorships in Pharmacology and Medicine at the Universities of Florence, Oslo, Messina, Vienna and Singapore. He is currently a Fellow of the Academy of Medical Sciences of the United Kingdom, a Foreign Member of the Academy of Sciences of Portugal (Lisboa), Member of the Council of the European Shock Society and the Federation of Shock Societies, Editor-in-Chief (Europe) of the journal Shock, Chief Executive of William Harvey Research Limited, and a Member of the Institute of Directors. According to the Institute of Scientific Information, he is

one of the 100 most-cited pharmacologists in the world (based on citations in the past 20 years). Professor Thiemermann’s major research areas include understanding ischaemiareperfusion injury, shock and multiple organ failure, His key aim overall is to develop novel approaches for the therapy of myocardial infarction, acute and chronic renal failure and shock. Whenever possible, we strive to translate the discoveries made in our experimental laboratories (Translational Research) into a better understanding of the pathophysiology of disease with the ultimate hope to improve therapy (Translational Medicine).

Adam Timmis MA MB BChir MRCP MD FRCP FESC Professor of Clinical Cardiology Professor Timmis’ research interests focus on outcomes of stable and unstable ischaemic syndromes and the effects of treatment and comorbidities, particularly diabetes. He holds research awards from the SDO (principle investigator) and BHF (co-investigator). He currently directs the coronary care unit at the Barts and The London Trust and participates in the interventional programme in the catheter laboratories of the London Chest Hospital.

Peter Vanezis OBE MBChB MD PhD FRCPath FRCP(Glas) DMJ(path) Professor of Forensic Medical Sciences Professor Vanezis has an international reputation in forensic medical sciences and was awarded the Order of the British Empire awarded in the Queen’s Birthday Honours List of June 2001 for his Forensic Pathology Services in Kosovo. He plans, over the next few years, to develop the various specialities in forensic medicine and allied subjects and to reintroduce forensic medicine as an academic discipline within the University of London. At the present time there are no academic centres in London. Thus there is no provision for training, teaching, research and development of the specialty. It is clear that there is an urgent need for the re-introduction of a viable forensic medical centre in the London and the South East of England. Professor Vanezis has introduced a forensic science option module on the Institute’s BMedSci course and his Forensic Human Identification course has proved popular with students. He is developing Diploma and Masters programmes in forensic medical sciences.

Tim Warner BSc PhD Professor of Vascular Inflammation Professor Warner’s research interests are into the formation and action of endothelial derived factors, especially prostanoids and endothelins. A particular focus of

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current research is the roles of different enzyme pathways in the formation of prostacyclin and thromboxane A2 in blood vessels and blood cells, and measures of platelet reactivity. Researches into platelet reactivity are being pursued in collaboration with clinical colleagues in the Haematology Department, the Ernest Cooke Vascular and Microvascular Unit, and the Cardiac Directorate of the Barts and The London NHS Trust. In collaboration with Professor Yuti Chernajovsky research is beginning into the use of rationally designed latent anti-inflammatory cytokines to reduce atherosclerotic disease in the walls of blood vessels. Within the European integrated project “Eicosanox” Professor Warner heads the William Harvey grouping, one of five main partners (together with Frankfurt University, the Karolinska Institute, University College London, and the University of Chieti) researching into the roles of eicosanoids and nitric oxide in health and disease. Eicosanox has a total budget in excess of £10 million. Experimental approaches used range from biochemical, molecular and cell culture techniques, through cell imaging, to classical pharmacological organ baths, and short term in vivo studies. Professor Warner is listed by the Institute for Scientific Information as being among the top 0.5 per cent of cited pharmacologists.

Magdi Yaqoob MB BS MD FRCP Lead Clinician, Academic Head and Unit training Director of the Department of Renal Medicine and Transplantation at the Barts and The London NHS Trust Professor Yaqoob’s research interests include experimental and clinical aspects of cardiovascular diseases in uraemia, clinical and experimental aspects of diabetic nephropathy, pleiotropic effects of erythropoietin, chemical nephrotoxicity and mediators of ischaemia reperfusion injury and clinical aspects of transplant immunology. Professor Yaqoob has participated and lead in many smaller and larger, multi-centre trials in renal and intensive care medicine.

Shu Ye MD PhD FRCPath Professor of Molecular Medicine and Genetics Professor Ye graduated in Medicine in China and obtained a PhD from University College

London. His main research interests focus on: The relationships of genetic variants with CHD risk and other cardiovascular traits; Functional characterisation of genetic variants using a variety of techniques; The role of Matrix metalloproteinases (MMPs) in atherosclerosis, in particular atheromatous plaque rupture. We are studying MMP expression profiles in atherosclerotic plaques, looking at the regulation of MMP genes in vascular endothelial cells and macrophages, role of MMPs in atherogenesis using in vivo models, and MMP gene variants in relation to atherosclerosis and CHD susceptibility; Inflammation plays an important role in the pathogenesis of atherosclerosis, we are undertaking studies into cell signalling in response to atherogenic molecules.

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Degree programmes William Harvey Research Institute

MSc/Postgraduate Diploma/Postgradu ate Certificate in Analytical Toxicology Two to five years part-time Programme description This programme is aimed primarily at those practising in the clinical field, but will be relevant and useful to students who wish to follow a career in forensic, pharmaceutical, or environmental toxicology as the skills and knowledge base needed for those disciplines are complementary and overlapping. The programme aims to provide a theoretical basis for gaining competence in the practical aspects of analytical toxicology; to develop competence in research and development activities; and to enable the participants to review analytical data critically. The modular nature of the programmes is designed to fit in with the needs of those students who are in full-time employment. The taught elements of the modules are delivered in threeday blocks every six weeks.

Programme outline Year 1 Module 1: Essential Clinical Toxicology • Module 2: Analytical Techniques I • Module 3: Analytical Techniques II • Module 4: Essential Therapeutics • Module 5: Trace Elements and

Toxic Metals • Module 6: Drug Abuse and Forensics Year 2 Module 7: Essential Clinical Biochemistry • Module 8: Laboratory Operation • Modules 9 – 12: Practical Project and Dissertation (or Critical Dissertation)

Assessment For a Postgraduate Certificate, students must complete and pass modules one to four. Successful completion of all eight taught modules leads to the award of the Postgraduate Diploma. Completion of a practical project and submission of a dissertation based on the project of approximately 20,000 words and successful completion of all eight taught modules is required for the MSc award. The assessment of the taught modules is 100 per cent by continuous assessment with submission by the student of essay-style answers, a series of shorter answers or a mixture of both.

Entry requirements For entry onto the programme students will need either an appropriate life sciences degree or equivalent from a recognised academic institution, or an appropriate professional qualification or experience acceptable to the Programme Director and Director of Graduate Studies. For language requirements, please see the international students section on page 133.

Further information Professor Atholl Johnston Tel: +44 (0)20 7882 3404 email: a.johnston@qmul.ac.uk

MSc/Postgraduate Diploma in Clinical Drug Development MSc/Postgraduate Diploma in Healthcare Research Methods One year full-time, two to five years part-time Programme description Over the last 30 years healthcare research and drug development have been transformed from peripheral activities carried out on an ad hoc basis to become core activities that require trained, professional staff. However, the education and training of staff involved in healthcare research and drug development has not kept pace with the scientific and regulatory changes that have occurred over this period. For this reason the Clinical Pharmacology Centre of the William Harvey Research Institute, in association with Barts and The London NHS Trust and Hammersmith Medicines Research, has developed modular postgraduate programmes in healthcare research and in clinical drug development. The programmes are designed to give individuals the necessary academic

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background and specialist skills needed to carry out clinical drug development or healthcare research in a contract research organisation, pharmaceutical industry or Health Service environment. Our target audience is graduates, nurses, medical doctors and other health professionals working in contract research organisations, the pharmaceutical industry and healthcare.

Programme outline These two postgraduate programmes share a common spine, which cover the key areas of expertise needed for a successful clinical research programme. For students choosing the Clinical Drug Development programme the initial modules will concentrate on early drug development whereas for those students taking the Healthcare Research Methods programme the emphasis will be related to health management. The modular nature of the programmes is designed to fit in with the needs of those students who are in full-time employment. The taught elements of the modules are delivered in threeday blocks every six weeks. Core modules Clinical Study Design • Practical Aspects of Clinical Research and Early Drug Development • Ethics and Regulation • Data Management and Statistics • Specific Topics in Clinical Trial

Design • Elective Dissertation • Health Outcomes and Pharmacoeconomics • Marketing Healthcare • Research Project/Dissertation Module options include: Health and the Human Body • Healthcare Organisation and Decision Making • Drug Discovery and Preclinical Research and Development • Toxicology

Assessment For a Postgraduate Diploma, students must complete and pass eight modules. Successful completion of a further four modules, two of which will comprise a critical dissertation of approximately 20,000 words, is required for the MSc award. The assessment of the taught modules is 100 per cent by continuous assessment with submission by the student of essay-style answers, a series of shorter answers or a mixture of both. These are marked and returned to the students according to the timetable specified in the Programme Handbook. There is no final written examination.

Entry requirements For entry onto the programme students will need either an appropriate degree or equivalent from a recognised academic institution, or an appropriate professional qualification (for example nursing) or experience acceptable to the Programme Director and Director of Graduate Studies.

For language requirements, please see the international students section on page 133.

Further information Professor Atholl Johnston Tel: +44 (0)20 7882 3404 email: a.johnston@qmul.ac.uk

MSc/Postgraduate Diploma in Endocrinology and Diabetes Two years part-time – distance learning Programme description The Postgraduate Diploma is designed both as a complete curriculum in endocrinology and diabetes for new entrants into these fields and as an update and extension for those already in it. The course provides clinicians with theoretical and clinically applied aspects of their discipline. The programme will incorporate elements of the UK specialty training curriculum for endocrinology and diabetes mellitus including aspects assessed at the knowledge-based examination required for Royal College Certification. In addition there will be a focus on up to date developments in the field and expert opinions and presentations. In addition, students taking the MSc do a project on a topic to be approved by the Course Organiser which is conducted at the candidate’s home institution. The

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Degree programmes William Harvey Research Institute

project is examined in the form of a written dissertation of approximately 10,000 words and a viva.

Programme outline Modules include: • Hypothalamus and pituitary • Thyroid, parathyroids and bone • Reproduction, pregnancy and paediatric endocrinology • Appetite, weight, energy metabolism, lipid metabolism • Adrenals (medulla and cortex) • Genetics, endocrine oncology, neuroendocrinology • Diabetes mellitus • MSc Project

Assessment Assessment for each module is completed during the progress of the module and submitted at the end of the module. The assessment format varies with each module (for example, EMQ and ‘best of 5’ multiple choice questions or short answer format or longer essays). There is an end-of-course summative assessment after completion of all eight modules. This comprises of a written paper comprising a combination of short answers, longer essay answers and ‘best of five’ multiple choice questions. The exam will assess content from each of the modules equally and the marks for the exam will be evenly distributed across the modules taught.

Entry requirements Qualification requirements for the course are MB BS or basic medical degree from universities recognised by the University of London. Candidates should generally have worked for one year after registration (two – three years post qualification). Applicants will be interviewed prior to acceptance and course entry may be competitive. Students must have access to a suitable computer and broadband access to the internet. Availability of minimum system specifications for using WebCT CE6 is required. Students must be able to sit examinations at a British Council Centre under invigilation or be able to attend examinations in the UK. For language requirements, please see the international students section on page 133.

Further information Dr Maralyn Druce Tel: +44 (0)20 7601 7078 email: m.r.druce@qmul.ac.uk

MSc/Postgraduate Diploma/ Postgraduate Certificate in Forensic Medical Sciences One year full-time, two to five years part-time Programme description This programme aims to respond to the national and international need for professionals who can apply a critical and scientific approach to their forensic practice, and who wish to have a broad understanding of the various interrelated disciplines of forensic medicine and science. The programme will provide theoretical and practical knowledge of the forensic medical sciences, and will train students to be able to critically evaluate and interpret forensic medical and scientific evidence. The programme will cover several aspects of forensic medical science and there is no other programme which offers such a wide range of specialist topics under the umbrella of the forensic medical sciences, coupled with the opportunity to carry out research in a specialist area. The programme offers the opportunity for graduates to further their career prospects within their own professional specialty. The programme should

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Neil Dufton, PhD in Inflammation and Immunology

‘‘

My tutor at Bath was a former friend and colleague of Professor Flower and both undertook their PhD research with John Vane who set up the William Harvey Institute. I came for an interview and was immediately struck by the enthusiasm for both my project and the progression of science in the department. I am currently getting to grips with a huge number of new techniques ranging from molecular biology, in vitro immunology and in vivo pharmacology so there is plenty to keep me out of trouble. I have two very dynamic Professors, Perretti and Flower, as my supervisors who are always open for discussion, often leading to a raft of new ideas for both current and future work. The group is always willing to help by either providing technical expertise or just bouncing ideas that may relate to their field of investigation. Charterhouse Square green is a great place to spend you lunch break when the sun is shining, and with three barbecues available for general use you will often see people gathering on a summer evening. The William Harvey has a good social scene with curry nights, barbecues and a marquee ball in the summer. There is also an annual five-a-side football tournament that often leads to some amusing rivalries between labs.

‘‘

I enjoyed convincing fifteen colleagues predominantly from my department to take part in a four-mile charity space hop around London City for Red Nose Day. It was a great day all round, especially seeing the professors on hoppers before we embarked round London, and we managed to raise more than £2,500. be regarded as intermediate level for pathologists and forensic medical examiners who will be expected to progress to specialist exit level exams, through their respective Academic Colleges.

Research project Laboratory based or a critical dissertation (four modules)

Programme outline

Assessment

Core modules

Full attendance is expected throughout the programme and is a pre-requisite for successful completion of the programme.

Clinical Aspects of Forensic Medicine (two modules) • Forensic Pathology (two modules) Module options Legal and Ethical Issues Relevant to Forensic Medicine and Science

• Forensic Toxicology I and II • Forensic Identification I and II

For a Postgraduate Certificate, students must complete and pass four modules. Successful completion of a further four

modules leads to the award of the Postgraduate Diploma, completion of a practical project by candidates awarded the Diploma and submission of a dissertation of approximately 20,000 words is required for the MSc award. The full programme comprises twelve modules, with each contributing equally to the final mark (one twelfth of the total). The result of one module contributes a maximum of 8.33 per cent and the project a maximum of 33.33 per cent to the final mark.

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Degree programmes William Harvey Research Institute

Core and other modules will be assessed through tutorial work (including paper presentations), submitted assignments, practical reports and short examinations (Short Answer Questions or Multiple Choice Question format). There will be variation in the relative contribution of each assessment method within modules.

Entry requirements For language requirements, please see the international students section on page 133.

Further information Professor Peter Vanezis Tel: +44 (0)20 7882 3401 email: p.vanezis@qmul.ac.uk

MRes Inflammation: Cellular and Vascular Aspects One year full-time Programme description The MRes in Vascular and Cellular Inflammation provides a practical training in modern molecular and proteomic research techniques and their application to traditional methods of pharmacological investigation of inflammatory and vascular disease mechanisms. The programme is specifically designed to develop the skills necessary to conduct biomedical inflammatory research, for example in rheumatoid arthritis,

Assessment

atherosclerosis, hypertension, diabetes, nephrology, or cancer, and draws upon the unique combination of expertise in inflammatory disease, vascular disease and pharmacology found in the William Harvey Research Institute. It is therefore an invaluable foundation if you wish to pursue a career in industry or academic research. Many students have continued on to carry out a PhD within the School.

Research project (64 per cent). This forms the major part of the assessment and is divided into three elements, project write-up (50 per cent), project presentation (6 per cent) and project viva (8 per cent).

Programme outline

Entry requirements

In the first term students follow an initial three-month course of tutorials and practicals to obtain a broad grounding in inflammation mechanisms, and to develop the necessary laboratory skills for conducting the project element of the programme. This is split up into generic skills (ie writing, presentation skills, statistics, laboratory safety and critical analysis), proteomics, molecular methods, immunological and pharmacological methods. In the following two terms, students are expected to apply a variety of techniques as part of an integrated research project under the guidance of an experienced academic supervisor.

The programme is suitable for life science graduates, with a minimum second class honours degree (or the equivalent from an overseas university), MB BS with or without an intercalated degree.

Coursework continues throughout the year. Students are able to develop their scientific understanding through the use of problem based learning (students write-up one PBL as a dissertation) and critical analysis and appraisal of key research papers.

Coursework (36 per cent), Critical analysis of the literature (24 per cent) and dissertation (12 per cent).

For language requirements, please see the international students section on page 133.

Further information Dr Martin Carrier Tel: +44 (0)20 7882 2104/2218 email: m.j.carrier@qmul.ac.uk

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Wolfson Institute of Preventive Medicine

Barts and The London School of Medicine and Dentistry 109

Wolfson Institute of Preventive Medicine www.wolfson.qmul.ac.uk

Institute Director

The Institute comprises:

Professor Nick Wald email: n.j.wald@qmul.ac.uk

• Centre for Environmental and Preventive Medicine

Director of Graduate Studies

• Cancer Research-UK Centre for Epidemiology, Mathematics and Statistics

Professor Stephen Duffy email: s.w.duffy@qmul.ac.uk

• Centre for Psychiatry

Key research areas Environmental and preventive medicine, epidemiology, antenatal screening, cancer screening, medical statistics and psychiatry. The Wolfson Institute of Preventive Medicine is an internationally renowned centre of excellence in epidemiology and preventive medicine that has again been highly rated in the recent Research Assessment Exercise (2008), with a grade point average (epidemiology) of 3.05. It is dedicated to the reduction of diseases and disability through its focus on academic discipline, research, the translation of research into public health strategies and their practical implications. The research foci are screening, early detection and disease prevention. The Institute has a strong interest in medical statistics where the work focuses on methods for running trials, analysing the data and developing new methodology for statistical problems arising from epidemiological research.

Centre for Environmental and Preventive Medicine (CEPM) CEPM focuses on large-scale randomised prevention trials, screening research (antenatal and cancer) and epidemiological studies into the causation of disease, especially cardiovascular. It includes the Tobacco Dependence Research Unit, one of the leading centres in this field that operates a large smokers’ clinic providing an ample clinical base, to support its extensive research programme. There are opportunities for postgraduate projects concerning both behavioural and pharmacological approaches to understanding and treating nicotine dependence.

Cancer Research-UK Centre for Epidemiology, Mathematics and Statistics (EMS) EMS focuses on mainly clinical trials and epidemiology and the work tends to be collaborative. Current areas of interest are cancers of the breast, uterine cervix, prostate and colorectum. The work of this Centre encompasses prevention studies, treatment comparisons, prognostic factors for survival and aetiological studies of risk factors

for developing disease. The centre also now is the home of the only Clinical Trials Prevention Unit for cancer prevention and screening trials in the UK.

Centre for Psychiatry The Centre for Psychiatry is a multidisciplinary centre of social scientists, psychologists and psychiatrists with special interest in ethnicity and culture, health services research and policy, and forensic, community and social psychiatry. The work of the Centre takes advantage of its location in a multicultural population of east London, whilst also being of importance to international mental health research. The Centre’s research includes strengths in: epidemiological psychiatry (environmental and cultural, forensic, bio-psycho-social) and mental health services research that develops concepts and processes in therapeutic interventions and trials of complex interventions. The Centre also delivers MScs in Transcultural Mental Healthcare and Psychological Therapies and works with NHS service providers in east London and national and international partners in research and policy. The Centre is pioneering E-learning and simulated learning environments and research into their effectiveness.

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Wolfson Institute of Preventive Medicine

visited the Centre and came away thinking that not only did they have a range of exciting projects but these Professors and their colleagues were friendly, easy to talk to and learn from. I was not wrong and enjoyed my time there immensely. This research environment kept me motivated throughout my studies and I finished my PhD in three years.

Graduate profile: Rhian Gabe Studied: An epidemiological / statistical based PhD on the evaluation of breast cancer screening using mammography – graduated 2007 Currently: I’m a senior statistician at the Medical Research Council’s Clinical Trials Unit (MRC CTU). I’m project lead for a number of innovative studies (randomised trials) that aim to find the best therapies and care for patients with cancer. Why did you choose Queen Mary? My background in mathematics and epidemiology, and an interest in cancer research led me to the Cancer Research UK centre for Epidemiology, Mathematics and Statistics at the Wolfson Institute. This department and the Medical School as a whole at Queen Mary have good international reputations for cancer research. I was very interested in cancer epidemiology and in particular breast cancer screening. I knew the Centre had some of the top researchers in this field (Professors Duffy, Cuzick, Sasieni) and I was familiar with their work. I

What did you gain from your time at Queen Mary? A greater in-depth knowledge of cancer screening and prevention. Less obvious, is the greater confidence acquired as a researcher, which comes from developing the right skill set, such as initiating and writing papers, presenting work at international conferences, formulating research ideas and applying for funding, and communication and contacts for successful collaborations. I also enjoyed meeting a variety of people and made some good friends along the way! What are your career plans in the next five years? While I’m lucky enough to have found a permanent position with the MRC, it’s still hard to know where your work will be in five years, as it depends on the projects we manage to get funded. I think studies in prostate and lung cancer, especially in the areas of prevention, screening or treatment of early disease should be high priority for cancer research. I’m trying to use my experience from my PhD and from clinical trials to take things in that direction with my current portfolio of work. The next step up in terms of a career at the MRC CTU would be “programme leader” (which is equivalent to a group lead in a university setting) and hopefully my current experience and efforts to get studies off the ground will help towards this.

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Senior staff research interests Wolfson Institute of Preventive Medicine

Staff profile: Dr David Wald Senior Lecturer and Consultant Cardiologist

‘‘

As an Interventional Cardiologist, my main interest lies in the prevention of cardiovascular disease, in particular bridging the interventional and preventive approaches to cardiovascular disease which are often viewed as distinct. I am currently coordinating a proposed randomised trial to assess the value of coronary angioplasty in preventing future coronary heart disease among patients receiving angioplasty to treat an acute myocardial infarction. This follows a randomised trial which showed the minimum fully effective dose of folic acid for serum homocysteine reduction, for which I was awarded the BMA Brackenbury Research Prize. I have acted as an adviser to the Food safety Authority of Ireland in helping them reach a decision on dietary fortication with folic acid. In collaboration with other members of the Institute, this led to research into the expected effect of folic acid intake on cardiovascular disease prevention. This in turn showed how even the largest randomised trials of folic acid supplementation were underpowered to show the expected effect. Another recent joint initiative involved showing that screening for familial hypercholesterolaemia, by serum cholesterol measurement, is effective if done in early childhood after the first year of life. This finding underpins a novel “child-parent” population screening strategy that screens children and their parents within the same programme. This involved assessing imaging techniques like carotid ultrasound and CT scanning in screening for coronary heart disease to determine their value in medical practice.

‘‘

Additionally, I coordinate the Polypill Prevention Programme, a novel service that adopts the Polypill approach in coronary heart disease and stroke prevention.

Kamaldeep Bhui MD FRCPsych(Lond) Professor of Cultural Psychiatryand Epidemiology Kamaldeep Bhui's research interests include methodological innovations for researching health and social care of cultural and ethnically defined population groups. Investigations are located at the interface between epidemiology and social anthropology to improve research quality in hard to reach and socially excluded populations and patient groups, for example, the homeless and refugees and asylum seekers. As part of research and service development roles, Professor Bhui pioneered the EPIC service innovations (enhancing pathways to care) and led on the outcomes compendium for professionals to use in mental health care. He is involved in the evaluation of a national programme to improve race equality in mental healthcare. He has championed cultural competency and cultural consultation processes to develop a skilled workforce that can deliver improved patient outcomes in a culturally diverse society. Current work includes a systematic review of the cultural competence literature, new data on suicide and self harm among ethnic groups, and MRC funded studies of chronic fatigue and chronic fatigue syndromes, including a systematic review of ethnicity and chronic fatigue. New work includes investigations of personality disorder (DH), work stress and the interventions to

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improve workforce stress (DH) and workforce capacity to work with diverse populations.

Jeremy Coid MB ChB(Sheff) MRCPsych Mphil Dip Criminol(Lond) FRCPsych MD(Lond) Professor of Forensic Psychiatry, Director of the Unit of Forensic Psychiatry Jeremy Coid’s current principle research interests are the epidemiology of violence and high risk behaviour and the associations between these behaviours and mental disorder. Current research, which includes an NIHR programme grant, comprises an evaluation of different methods of risk assessment for further serious offending in prisoners released into the community, the transmission of delinquency from fathers to their children, and a prospective study of first episode psychosis in east London. Previous research has examined the development of secure forensic psychiatry services in England and Wales and admissions to these facilities in relation to socio-economic deprivation. He is currently Consultant in Forensic Psychiatry to the East London Forensic Psychiatry service, Consultant Adviser to the National Institute of Mental Health, a member of the Research Advisory Group to the Home Office in their programme for Dangerous and Severe Personality Disorder, and is a member of the monitoring

group of the Close Supervision Centres, Prison Directorate.

Jack Cuzick BSc(Claremont, California) MSc(Lond) PhD(Claremont, California) , FMedSci, FRSS, FIMS John Snow Professor of Epidemiology, Head of Cancer Research-UK Centre for Epidemiology, Mathematics and Statistics Jack Cuzick’s interests are in cancer prevention and screening with special attention to breast, cervix, colon and prostate cancer, and the development of statistical methodology. He is working with the aromatase inhibitors both for treatment and prevention of oestrogen receptor positive postmenopausal breast cancer. He is conducting the IBIS-II chemoprevention trial comparing anastrozole with placebo in 6,000 high risk women. There is also interest in mammographic breast density as a biomarker for risk and early indications of risk reduction when interventions are used. The main thrust in cervical cancer has been the use of HPV DNA testing in screening with a recent Lancet paper on the HART study of 11,000 women. A large study of 2,500 men with clinically localised prostate cancer treatment is ongoing by watchful waiting. Tissue arrays have been prepared to look for new markers of aggressive disease and several papers have been published. A large randomised trial of onceonly flexible sigmoidoscopy as a population based screening method for colorectal cancer in

men and women aged 55-64 is also in the late follow-up stage. He is currently president of the International Society for Cancer Prevention.

Stephen Duffy BSc(Edin) MSc(Lond) C Stat Professor of Cancer Screening Stephen Duffy’s main research interests are: cancer screening evaluation; markers of cancer risk and prognosis; and epidemiology of dense, high-risk breast patterns. Grant-funded research includes the NHS-funded evaluation of mammography screening in young women with a family history of the disease, a feasibility study for a lung cancer screening trial in the UK, also funded by the NHS, and an investigation of computer-aided detection in breast screening, funded by Cancer Research UK. Recent publications include a paper on the use of computeraided detection in the New England Journal of Medicine and a commentary on the possibilities for collaboration in lung cancer screening in Lancet Oncology.

Peter Hajek MA(UJEP) PhD(Charles University) C Clin Psychol Professor of Clinical Psychology Peter Hajek’s main research interest focuses on tobacco dependence and its treatment. He directs the Tobacco Dependence Research Unit at the Royal London Hospital. He has contributed to the development of a range of behavioural and pharmacological treatments for

114 Barts and The London School of Medicine and Dentistry

Senior staff research interests Wolfson Institute of Preventive Medicine

dependent smokers used in the UK and worldwide. His unit is also involved in studies of weight management. His research has been supported by grants from sources such as DoH, Wellcome Trust, MRC, HDA, NELHA, pharmaceutical industry and others. He is a member of a number of editorial boards, expert groups and advisory committees, and his Unit is a part of the UK Centre for Tobacco Control Studies.

Ania Korszun PhD MB BS MRCPsych Professor of Psychiatry and Education Ania Korszun’s research focuses on mood disorders and particularly on the interface of depression and stress with other medical conditions. She has completed studies on hypothalamic-pituitary-adrenal axis function in facial pain, fibromyalgia and chronic fatigue syndrome and has been Co-PI on large multi-centre genetic studies of depression. Further work has focused on identifying the underlying pathophysiological mechanisms that link depression, stress and atherosclerosis, namely endothelial dysfunction and reduced baroreceptor sensitivity. More recently, she is working in collaboration with colleagues from surgery and oncology on the identification of psychological and physiological predictors of treatment outcome in cancer patients.

Ania Korszun maintains a strong commitment to medical education. She is the Academic Lead for Psychiatry Education, Systems Lead for Brain and Behaviour and Academic Tutor in Medical Professionalism at Barts and The London School of Medicine and Dentistry, Queen Mary, University of London. She is conducting research on undergraduate teaching and assessment of medical professionalism and the effectiveness of interdisciplinary teaching of clinical skills in psychiatry and leading a large multidisciplinary project that focuses on overcoming stigmatizing attitudes to mental health.

Malcolm Law MB BS(Adelaide) FFPH FRCP MSc(Lond) Professor of Epidemiology and Preventive Medicine Much of Malcom Law’s work has been in the prevention of heart disease and stroke, with seminal publications on salt and blood pressure, serum cholesterol and heart disease, passive smoking and heart disease, and the reasons for the low heart disease mortality in France (the French paradox). Quantification of the effects of changing risk factors on the incidence of myocardial infarction and stroke has been a prominent feature of his work. Publications with Professor Wald and other colleagues on the effect of statins (according to specific statin and dose) on LDL cholesterol and on risk of heart disease and stroke, of the five

main categories of blood pressure lowering drug according to dose on blood pressure and on risk of heart disease and stroke, and of folic acid on serum homocysteine and risk of heart disease and stroke led to the calculations of the effect of the ‘Polypill’ in preventing ischaemic heart disease events by 88 per cent and stroke by 80 per cent.

Attila Lorincz PhD Professor of Molecular Epidemiology Attila T Lorincz is a molecular biologist recognized for his research in human diagnostics and the natural history of human papillomavirus (HPV) infections. Attila Lorincz’s work on HPV began as a collaboration with the Nobel Laureate Professor Harald zurHausen. In the years leading up to 1990 he cloned and characterized several clinically important HPV types, provided a clearer understanding of the natural history of HPV infection and pioneered large clinical studies that revealed key evidence of the association of HPV with cervical cancer. In 1990 Attila Lorincz co-founded Digene Corporation (now QIAGEN Corp.) where he assumed the post of Sr. Vice President R&D until 2006. His work on a non-radioactive assay for HPV culminated in the US FDA approval of the Hybrid Capture (HC) series of HPV tests. These nucleic acid amplification tests are generally recognized as the gold standard in routine HPV screening worldwide, with 10+ million tests conducted annually.

Barts and The London School of Medicine and Dentistry 115

James Cook, PhD in medical statistics

‘‘

I am currently looking at the prevalence of trisomy 13 and trisomy 18 in England and Wales as part of my PhD in medical statistics. I'd heard good things about the quality of research at Queen Mary, it was part of the reason I chose to study here. I’m now surrounded by excellent researchers, all of whom are happy to help and support me however they can. Working in central London has its perks too! The facilities are amazing. Charterhouse Square and Whitechapel both have superb departments for medical research, and the Educational and Staff Development (ESD) department at Mile End is great for learning more general skills. Sitting outside in Charterhouse Square is a great place to work in the summer.

‘‘

I also work as a Problem Based Learning (PBL) facilitator on the undergraduate medical degree programme. It's a really interesting way to teach, which I think works much better than constant lectures.

More than 40 US and international patents concerning novel HPV types and novel assay systems have been awarded for his work. He has authored 210 original peer-reviewed research papers and books on diverse topics in epidemiology and the basic molecular mechanisms of carcinogenesis. His current research interests focus on the interplay between genetics and epigenetics in the development and evolution of prostate, breast, and cervical cancers. His team have discovered and credentialed several new cancer biomarkers that appear promising in diagnostics and are being investigated for prognostic and predictive potential.

Joan Morris BA MA(Cantab) MSc(Oxon) PhD(Lond) Cstat Professor of Medical Statistics Joan Morris’s main research interest is in evaluating the effectiveness of prenatal screening strategies for different disorders, for example cystic fibrosis, fragile X syndrome, neural tube defects and Down’s syndrome. As Director of the National Down Syndrome Cytogenetic Register she has a strong interest in the screening of, and epidemiology of, Down’s syndrome. She is interested in statistical methodology with relevance to screening and risk assessment. Her work with Professors Nicholas Wald and Malcolm Law has involved many meta-analyses investigating the value of low dose combination treatment with blood pressure lowering drugs, and the

associations of folate and serum homocysteine with cardiovascular disease, culminating in the publication of a trio of papers in the British Medical Journal on the prevention of cardio-vascular disease by the use of the ‘Polypill’.

Stefan Priebe Dipl-Psych, Dr. med. (Hamburg) habil. (Berlin) Professor of Social and Community Psychiatry, Director of the Unit for Social and Community Psychiatry Stefan Priebe’s extensive research activities have focused on three areas: mental health services research including outcome studies and trials of complex and innovative interventions; patient views (eg subjective quality of life and treatment satisfaction), therapeutic relationships and therapeutic communication in psychiatry; and studies on the

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Senior staff research interests Wolfson Institute of Preventive Medicine

history and concepts of mental healthcare. He has a special interest in advancing methodological and conceptual issues, has co-ordinated a number of major European multicentre studies and is Deputy Director of the Pragmatic Clinical Trials Unit. He is author/ editor of eight books and has more than 400 scientific publications, two thirds of them in peer-reviewed journals. He reviews on social psychiatric issues for most leading journals and research funders and is on the editorial board of several journals, including Psychiatrische Praxis and the International Journal of Social Psychiatry. Professor Priebe is visiting professor at the Humboldt University Berlin, the University of Modena and Reggio Emilia, and the University of Belgrade. He has been a member of the National Mental Health Task Force in England and acting as advisor on mental healthcare development to regional and national bodies in several European countries.

Peter Sasieni BA MA(Cantab) MS PhD(University of Washington) Professor of Biostatistics and Cancer Epidemiology Professor Sasieni’s research focuses on cancer screening and the prevention of cervical cancer both in the developed and the developing world. He is also interested in statistical methodology with relevance to clinical trials and epidemiological research. He is currently running a randomised controlled trial of diindolylmethane (DIM) in the

treatment of women with mildly abnormal cervical smears in an attempt to prevent progression to high-grade disease. His publications include Benefit of Cervical Screening at Different Ages: evidence from the UK Audit of Screening Histories (2003), as well as numerous papers on Human Papillomavirus (HPV) testing, breast screening and statistical methods in survival analysis. He also maintains an interest in statistical analysis of data from molecular biology. He holds research awards/grants from Cancer Research-UK, the NHS Cervical Screening Programme and the European Union.

Stephen Stansfeld MB BS PhD(Lond) MRCP MRCPsych Professor of Psychiatry, Centre Lead for Psychiatry Stephen Stansfeld’s research interests include the effects of the physical and social environment on mental health. He has been involved in several studies examining environmental noise

and mental health and more recently on noise and children’s health and cognition. He was previously Co-Director of the Whitehall II Study and is particularly interested in the psychosocial work environment and social support as predictors of common mental disorder. He has also investigated the explanations of the social gradient in psychological distress in the Whitehall II Study and with Professor Chris Power in the 1958 Birth Cohort. He is interested in psychosocial influences, especially depression, on coronary heart disease and has co-edited a book on the impact of the environment on psychiatric disorder. He is principal investigator in the RANCH and RELACHS Studies. He also works as a consultant psychiatrist in psychiatric rehabilitation.

Nicholas Wald MB BS DSc(Lond) FRCP FFPH FRCOG FMedSci CBiol FlBiol FRS Institute Director Wolfson Institute of Preventive Medicine Professor Wald is known for his research in epidemiology and preventive medicine. He has pioneered the field of antenatal screening for congenital malformation and made discoveries that form the basis of screening for neural tube defects and Down’s syndrome in early pregnancy. He showed, in a large randomised trial, that a lack of folic acid is a cause of neural tube defects, and that an adequate intake of the vitamin immediately before pregnancy can prevent

Barts and The London School of Medicine and Dentistry 117

most cases. He has demonstrated that passive smoking is a cause of lung cancer and with Professor Law showed it also increased the risk of ischaemic heart disease. Screening procedures for early detection of certain cancers, notably breast cancer, have been advanced from his work. With Professor Law, he clarified the relationship between salt intake, blood pressure and cardiovascular disease. Recent research activities include screening and treatment for Heliocobacter pylori infection and subsequent stomach cancer, and screening and treatment of hypothyroidism in pregnancy and subsequent intellectual development in children. He is the innovator of the ‘Polypill’, a radical approach to the prevention of cardiovascular disease, and trials are being developed. He has published widely in these areas over the past 30 years. His book, Antenatal and Neonatal Screening, won first prize in the BMA Medical Book Competition (2001) in the public health category.

Peter White OBE BSc MB BS MD(London) FRCP FRCPsych Professor of Psychological Medicine Peter White’s main research is in mind-body medicine, exploring the aetiology and treatment of fatigue and pain, specifically chronic fatigue syndromes (CFS – also known as myalgic encephalomyelitis, ME), post-viral fatigue syndromes, and diffuse upper limb pain disorder. Research successes include: establishing and replicating the discrete nosology of both acute and chronic fatigue syndromes after glandular fever, showing Epstein-Barr virus can trigger CFS, establishing the heterogeneity of CFS in general, demonstrating the interaction between mind and body in the pathophysiology of CFS, and providing the first evidence (since

replicated) that graded exercise therapy is an effective treatment of CFS. His work in regional upper limb pain has shown that both physical and psychological factors are important whether or not the pathology is established, and that pain is likely to be maintained by central nervous system sensitization. He is currently chief investigator of the PACE trial (www.pacetrial.org); the largest ever treatment trial for CFS. His recently edited book Biopsychosocial Medicine (OUP) concludes that an integrated biopsychosocial management approach should be mandatory for all chronic medical conditions.

118 Barts and The London School of Medicine and Dentistry

Degree programmes Wolfson Institute of Preventive Medicine

MSc/Postgraduate Diploma in Mental Health: Psychological Therapies MSc/Postgraduate Diploma in Mental Health: Transcultural Mental Healthcare PgCert Advanced Mental Health Assessment One year full-time, two years part-time. Distance learning option available Programme description Students on this programme aim to: • Develop more advanced understanding of the basis of assessment, diagnosis, formulation and care management of psychological disorders in general and then in diverse racial, ethnic and cultural groups drawing on cultural psychiatry, social sciences and allied disciplines • Have access to an academic programme that prepares competent practitioners to deliver effective mental health treatments for people with psychological problems

• Develop knowledge of research methods and systematic and critical review • Develop and have access to a network of mental health professionals and established academics Students on the Transcultural Mental Healthcare programme will learn how to improve their assessment of mental health problems. The specific strength of the MSc is that students will develop a knowledge base informed by a social anthropological, medical, sociological, epidemiological and pharmacological understanding of the presentation, expression and management of mental disorders and psychological distress amongst Black and Ethnic minorities. Students on the Psychological Therapies programmes will also learn and utilise an advanced level of knowledge derived from different psychological interventions including: • Therapeutic paradigms • Cognitive behavioural therapies • Cognitive analytic therapies

Programme outline The MSc programme consists of three 12 week modules. Module 1 (Advanced Mental Health Assessment) is compulsory and completion of this alone is accredited for exit with a certificate in mental health assessment. This is a compulsory module for all students. Module 2 We offer two pathway options: psychological therapies or transcultural mental healthcare. Completion of this module and module one permits exit with a diploma in either Psychological Therapies or Transcultural Mental Healthcare. Module 3 This is compulsory to all students and includes research methods and evidence based practice. Students aiming for the MSc award are required to undertake a dissertation on an original topic that includes original research or an original and comprehensive literature review using systematic methods wherever possible. Completion of modules one, two and three is accredited for exit with an MSc in either Psychological Therapies or Transcultural Mental Healthcare.

• Group therapies • Family therapy • Psychoanalytic and psychodynamic therapies • Bio-psycho-social model

Postgraduate Certificate Full-time: completion in one term Part-time – N/A

Postgraduate Diploma Full-time: both modules are completed in Year One. Part-time: One module is completed in each year.

Barts and The London School of Medicine and Dentistry 119

MSc Full-time: all three modules are completed in one year. Part-time: we advise students that it is best to complete the first two modules in the first year, and the third (research module) in Year Two. However, we permit flexibility if individual circumstances require this and if this still provides the student with the best chances of progressing. The MSc programme includes three modules, each lasting 12 weeks, and each with 12 core teaching and learning days. These are complemented by a half-day work placement (Transcultural Mental Healthcare students) for module two or half a day a week of supervised treatment of two short cases of 12 to 20 sessions (for students following the Psychological Therapies pathway) to develop better practices in real clinical settings. Students prepare a report on this as part of the programme assessment for modules one and two. There are also PBL sessions (one a week), and time is required to read two key references each week and provide a prĂŠcis each week.

Assessment Module 1: Practice placement plan, clinical therapy (one brief therapy), research or literature review plan, tutor's assessment report on PBL write ups, oral and written examination. Module 2: Practice placement report or clinical practice (two brief cases), pilot study report for the main study, student presentation, tutor's assessment report on PBL write ups and oral and written examination. Module 3: Tutor's assessment report on PBL write ups and attendance, grant writing report, dissertation (10-15,000 words), supporting publications and written examination. Both programmes are also available as distance learning options. All students have access to our established E-learning facilities for each programme module, including: online programme syllabus (student handbook); Tools for E-lecture materials; Tools for online PBL materials; Tools for submitting online assignments/homework

WebCT email; Virtual discussion board; Virtual classrooms (synchronous); E-calendar Tools for online student feedback; Tools for students to track online results/progress; E-notice board and Skype tutorials as well as Skype add-ons (ie whiteboard) to facilitate virtual classroom interactions. In addition, lectures are recorded using screen capture technology and then uploaded onto WebCT.

Entry requirements Applicants should have a basic degree in a related subject and/or a professional qualification and have worked in the relevant subject area for at least one year. We wish to include people from diverse backgrounds and career pathways especially people working in the independent and voluntary sector and NHS. For language requirements, please see the international students section on page 133.

Further information Dr Nasir Warfa, Tel: +44 (0)20 7882 2035 email: n.warfa@qmul.ac.uk

How to apply

Barts and The London School of Medicine and Dentistry 121

How to apply

All applications should be made on an official application form. Application methods Applications should be made on the official application forms. There are two ways in which you can apply for a postgraduate programme: 1) Apply online â&#x20AC;&#x201C; using our online application form This is our preferred method of application. Please go to our website for further details of how to apply online: http://www.qmul.ac.uk/ postgraduate/apply/index.html 2) Paper-based application You will find an application form inserted at the end of this prospectus. Please complete it carefully and return to the address at the bottom of the form.

If no application form is enclosed, or if it has been misplaced or damaged, please contact the Admissions and Recruitment Office for a replacement. The application form can also be obtained from the Queen Mary website: www.qmul.ac.uk/postgrad/ pgapplyq.shtml The Admissions and Recruitment Office is happy to answer any general application queries you may have. If you would like more information on programme content, then please contact the person listed at the end of the relevant programme description. To apply for research programmes, please first contact the relevant person in the School in which you would like to study.

There are no closing dates for applications to postgraduate study, although entry to some programmes is very competitive and places may be full several months before the start of the academic year. If you are concerned about programmes filling up and would like advice on availability, please contact the Admissions and Recruitment Office. International students applying overseas may wish to contact one of our representatives in-country. See www.qmul.ac.uk/international/ countries/ for more information. Admissions contact details Freephone 0800 376 1800 If calling from outside the UK: +44 (0)20 7882 5511 email: pgsmd@qmul.ac.uk

Tuition fees

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Tuition fees

Undertaking postgraduate study is a serious commitment and involves careful financial planning at the time of application and for the duration of the programme. Prices will almost inevitably rise and you must allow for this when planning your finances. Your costs will comprise tuition fees and living costs. The postgraduate fee rates for 2010/11 are as follows: Home/EU students

Overseas students

Programme

Level

Full-Time

Part-Time Full-Time Part-Time

Advanced Mental Health Assessment

PgCert

£1,900

N/A

Aesthetic Surgery

PgDip

N/A

£2,400

N/A

£3,100

Analytical Toxicology

PgDip

N/A

£3,200

N/A

£13,100

Burn Care

PgDip

N/A

£2,100

N/A

£2,600

Cancer Therapeutics

MSc

£6,000

£3,000

£16,200 £8,400

Clinical Dermatology

PgDip

£3,600

N/A

£4,600

Clinical Drug Development

MSc

£2,500

£13,000 N/A

N/A

Clinical Drug Development

PgDip

£4,000

£8,200

Clinical Microbiology

MSc

£8,200

£2,000

£13,200 £4,300

N/A

Clinical Microbiology

PgDip

£8,200

£2,000

£13,200 £4,300

Dental Clinical Services

PgDip

N/A

£14,990 N/A

Dental Clinical Services (Enhanced)

PgDip

N/A

£23,400 N/A

Dental Public Health

MSc

£9,500

£4,750

£14,990 N/A

Dental Technology

MSc

£9,500

N/A

£23,400 N/A

Dental Technology

PgDip

£7,000

N/A

£14,990 N/A

Dental Technology

PgCert

£4,750

N/A

£7,495

N/A

Endocrinology and Diabetes

MSc

N/A

£2,000

N/A

£2,500

Endocrinology and Diabetes

PgDip

N/A

£3,900

N/A

£4,900

Endodontic Practice

PgDip

N/A

£7,000

N/A

Experimental Oral Pathology (Oral Sciences)

MSc

£9,500

N/A

£14,990 N/A

Forensic Medical Sciences

MSc

£6,400

£3,200

£12,900 N/A

Gastoenterology (12 month)

MSc

£5,800

N/A

£15,700 N/A

Gastroenterology

PgDip

£3,600

N/A

£11,700 N/A

Gastroenterology (24 months)

MSc

N/A

£24,400 N/A

Health Care Research Methods

MSc

£2,500

£4,000

£13,300 N/A

Implant Dentistry

MSc

N/A

£4,750

N/A

Inflamation: Cellular and Vascular Aspects

MRes

£6,000

N/A

£16,200 N/A

Mental Health: Psychological Therapies

MSc

£4,000

£2,000

£7,600

N/A £4,900

124 Barts and The London School of Medicine and Dentistry

Tuition fees

Home/EU students

Overseas students

Programme

Level

Full-Time

Part-Time Full-Time Part-Time

Mental Health: Psychological Therapies

PgDip

£3,000

£1,500

Mental Health: Transcultural Mental Healthcare

MSc

£4,000

£2,000

£7,600

£4,900

Mental Health: Transcultural Mental Healthcare

PgDip

£3,000

£1,500

£5,500

£3,800

Molecular Pathology and Genomics

MSc

£6,000

£3,000

£16,200 £8,400

£5,500

£3,800

Non Invasive Aesthetic Techniques

PgCert

N/A

£2,500

N/A

Operative Gynaecology and Minimally Invasive Skills

MSc

£12,000

N/A

£24,100 N/A

£3,000

Operative Gynaecology and Minimally Invasive Skills

PgDip

£9,000

N/A

£14,200 N/A

Operative Orthopaedic and Arthroscopic Skills

MSc

£12,000

N/A

£24,100 N/A

Operative Orthopaedic and Arthroscopic Skills

PgDip

£9,000

N/A

£14,200 N/A

Oral Biology

MSc

£12,000

N/A

£24,000 N/A

Oral Medicine

MClinDent

£20,000

N/A

£34,000 N/A

Oral Surgery

MClinDent

£20,000

N/A

£34,000 N/A

Orthodontics

MSc

£20,000

N/A

£34,000 N/A

Orthodontics

MSc

N/A

£10,000 N/A

Paediatric Dentistry

Associate

£15,000

N/A

£34,000 N/A

Paediatric Dentistry

MClinDent

£20,000

N/A

£34,000 N/A

Paediatric Dentistry

MClinDent

N/A

£10,000 N/A

Periodontology

Associate

£15,000

N/A

£34,000 N/A

Periodontology

MClinDent

£20,000

N/A

£34,000 N/A

Primary Care

MSc

£4,600

£2,300

£11,800 £5,900

Primary Care

PgDip

£4,200

N/A

£11,100 N/A

Prosthodontics

Associate

£15,000

N/A

£34,000 N/A

Prosthodontics

MClinDent

£20,000

N/A

£34,000 N/A

Public Health

MSc

£4,600

£2,300

£11,800 £5,900

Sports and Exercise Medicine

MSc

£6,200

£3,100

£13,300 N/A

Sports and Exercise Medicine

PgDip

£4,800

£2,400

£11,700 N/A

Surgical Skills and Science

MSc

£12,000

N/A

£24,100 N/A

Translational Neuroscience

MSc

£3,600

N/A

£14,400 N/A

Translational Neuroscience

PgDip

£2,500

N/A

£9,300

N/A

Translational Neuroscience

PgCert

£1,200

N/A

£4,600

N/A

Please note that these fees are correct at the time of going to print, and may be subject to change. For part-time programmes the fee quoted is payable each year. For the most up to date fees, please see www.qmul.ac.uk/tuitionfees

Barts and The London School of Medicine and Dentistry 125

For a comprehensive list of international tuition fees and scholarships, please see the website: www.qmul.ac.uk/international/fees finance If you are in doubt as to whether you will be classed as an overseas or home student please consult the Admissions and Recruitment Office at an early stage. No additional charges are made for registration, examinations, or membership of the Students’ Union. Additional costs will be incurred, however, in the following cases: • Students attending field or language courses away from the College will be required to pay part or all of the cost • Examination re-entry fees are charged to students who are not in attendance • Research students taking longer than twelve months after finishing their research to write up their thesis will become liable to pay a writing-up fee equivalent to the relevant parttime fee. The Research Councils and many other funding bodies pay fees direct to the College. Students who are not sponsored by public bodies, either in this country or abroad, are required to pay their fees either before, or at the time of enrolment at the beginning of the session.

Living costs and funding your study

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Living costs and funding your study

Living costs The cost of living in London depends on your lifestyle. Typically, however, postgraduates need at least £11,000 to cover food, accommodation, travel, books and so on for a full year (52 weeks), plus adequate funds to maintain any dependants. International students will need to show evidence of having at least £7,200 for living costs plus 100 per cent of tuition fees in order to obtain Entry Clearance under Tier 4 of the UK Border Agency’s Points Based System of immigration. Additional amounts need to be shown for dependants. £7,200 is based on nine months of study and is an immigration requirement only – most students require more money than this for 12 month’s living costs – normally around £11,000. Please note that while the College will offer advice to students who encounter financial difficulties, it is not able to fund postgraduate students who have started a programme without adequate or reliable funding. Although hardship funds may be available, payments are small and cannot cover fees or compensate for not having adequate funding in place.

Funding your study Unfortunately there are no mandatory awards for postgraduate study, and alternative funding sources are limited. Consequently it is vital that you consider how you will pay your fees and maintain yourself at

an early stage in the application process. All funding information for taught and research students is available on our website. Please visit: www.qmul.ac.uk/postgraduate/fee sfunding/index

Research students Possible funding sources to consider include: • Queen Mary, University of London Research Studentships • Research Council Studentships • Career Development Loans • Charities and Trusts.

Queen Mary, University of London Research Studentships (Home, EU and International students) The College offers a number of research studentships each year, which are tenable for up to three years. The studentships cover tuition fees and provide maintenance at the basic research council level (for guidance: £15,290 during the 2009/10 session). Any applicant for admission to an MPhil or PhD programme to commence in the 2009/10 session will automatically be considered for a studentship, there is no separate application form. Details on the number of studentships available in each department can be obtained directly from the department. PhD studentships, including those linked to specific funded projects within the College, are advertised

on our website as well as the following external websites: www.findaphd.com and www.jobs.ac.uk

Research Council Studentships (Home and EU students only) These are the primary source of funding for Home and EU students and cover tuition fees and maintenance costs. They are available for research and some Masters programmes. Candidates must ordinarily be resident in the UK for a period of three years prior to the date of application (excluding any period spent in further or higher education). The studentships are normally only available for candidates who have obtained a first degree of good honours standard.

128 Barts and The London School of Medicine and Dentistry

Living costs and funding your study

For further information about funding via the respective Research Councils please visit their websites: • The Arts and Humanities Research Council (AHRC) www.ahrc.ac.uk • Biotechnology and Biological Sciences Research Council (BBSRC): www.bbsrc.ac.uk • Engineering and Physical Sciences Research Council (EPSRC): www.epsrc.ac.uk • Science and Technology Facilities Council (STFC) (incorporating former Partcle Physics and Astronomy Research Council (PPARC): www.scitech.ac.uk • Economic and Social Research Council (ESRC): www.esrc.ac.uk • Natural and Environmental Research Council (NERC): www.nerc.ac.uk • Medical Research Council (MRC): www.mrc.ac.uk To be considered for research funding from the research councils, contact the relevant academic department for details on the application process. Most of the research councils now operate schemes where Queen Mary is given a set amount of funding and selects the students to whom this will be offered – prospective students do not apply directly to the research council.

Professional and Career Development Loans (Home and EU students)

China Scholarship Council scholarships (International students only)

Postgraduate students wishing to undertake certain programmes to enhance their career development, who cannot obtain alternative funding, may borrow a maximum of £8,000 to cover 80 per cent of tuition fees plus living expenses. Repayments are delayed and the Government pays the interest for the duration of your study and for one month afterwards. Details are available from the Directgov website (www.direct.gov.uk) and participating banks.

Queen Mary Joint PhD Scholarships with the China Scholarship Council. Available to students from China for PhD study in various areas. Under this scheme Queen Mary, University of London provides a scholarship to cover all tuition fees and the China Scholarship Council (CSC) provides living expenses and one return flight ticket to successful applicants. Please refer to: http://www.qmul.ac.uk/internation al/scholarships/index.html#CSC

British Council Awards (International students only) A number of scholarships are awarded via the British Council’s representatives in an applicant’s country of origin. This scheme operates in approximately 70 countries. The British Council publicises the awards and is responsible for the selection of candidates. See: www.britishcouncil.org. The British Council may also be able to give information on other schemes operating in particular countries.

Chevening Scholarships (International students only) This is a special scheme to fund study by individuals who are identified as having potential to make a particular contribution to their country’s future. For further details see: www.chevening.com/

Queen Mary, University of London – Bangladesh Capacity Building Scholarships (International students only) Queen Mary is keen to contribute actively to the development of the higher education sector in Bangladesh and is pleased to announce the creation of two Queen Mary, University of London – Bangladesh Capacity Building Scholarships. Each of these scholarships will provide full tuition fees for full time MPhil/PhD study at Queen Mary in one of the following areas: Biological and Chemical Sciences, Computer Science, Electronic Engineering, Engineering, Materials, Mathematical Sciences and Physics. For more information, see: www.qmul.ac.uk/international/ scholarships/index.html

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Or contact: Ms Runa Noman Alpha-i Consultants Ltd House:99 (4th Floor) Road: 11/A Dhanmondi R/A Dhaka-1209 Tel: 880-2-9111957 Mobile: 01712-018876; 01713040100 email: counsel@global-bd.net www.alphai.co.uk Ms Angeliki Polatou The Graduate Admissions Office Queen Mary, University of London London E1 4NS Phone: +44 20 7882 3080 email: a.polatou@qmul.ac.uk

Queen Mary, University of London – Pakistan Capacity Building Scholarships (International students only)

For more information, see: www.qmul.ac.uk/international/ scholarships/index.html

Queen Mary is keen to contribute actively to the development of Pakistan’s higher education sector and is pleased to announce the creation of two Queen Mary, University of London – Pakistan Capacity Building Scholarships. Each of these scholarships will provide full tuition fees for full time MPhil/PhD study at Queen Mary in one of the following areas: Biological and Chemical Sciences, Computer Science, Electronic Engineering, Engineering, Materials, Mathematical Sciences and Physics.

Or contact: Mr Nabeel Vehra Regional Manager email: n.vehra@qmul.ac.uk Mr Mahmood Ur Rehman Business Development Manager email: m.u.rehman@qmul.ac.uk Queen Mary, University of London (Regional Office) Tel: +92 42 5692705 Fax: +92 42 5692706

130 Barts and The London School of Medicine and Dentistry

Living costs and funding your study

Ms Angeliki Polatou The Graduate Admissions Office Queen Mary, University of London London E1 4NS Phone: +44 20 7882 3080 email: a.polatou@qmul.ac.uk

Taught Masters students There are also some scholarships for international students. Please refer to www.qmul.ac.uk/international/ scholarships/

AHRC (Home, EU only) For Arts and Humanities disciplines only. Apply to the relevant academic department for details.

Westfield Trust Bursaries (Home, EU and International students) A small number of Westfield Trust bursaries worth £2,000 are available each year to students on selected taught postgraduate programmes. Any applicant for admission to one of the selected programmes will be automatically considered for a bursary, and there is no separate application form. Details are available from the Admissions and Recruitment Office from January each year.

College Postgraduate Bursaries (Home, EU and International students) A small number of Westfield Trust bursaries worth £2,000 are available each year to students

on selected taught postgraduate programmes. Any applicant for admission to one of the selected programmes will be automatically considered for a bursary, and there is no separate application form. International Students are eligible for the bursary, but will only receive the equivalent of the Home/EU fee deducted from the tuition fee Details are available from the Admissions and Recruitment Office from January each year.

Professional and Career Development Loans (Home and EU students) Postgraduate students wishing to undertake certain programmes to enhance their career development, who cannot obtain alternative funding, may borrow a maximum of £8,000 to cover 80 per cent of tuition fees plus living expenses. Repayments are delayed and the Government pays the interest for the duration of your study and for one month afterwards. Details are available from the Directgov website (www.direct.gov.uk) and participating banks.

Casual/part-time paid work – earning while you study Postgraduate students are allowed to undertake part-time work, but the hours you are able to work will be constrained by the demands of your studies. International

students can work for up to 20 hours a week in term-time and full-time during the vacations. We know that many students may need to supplement their income while they study and we do our best to help facilitate this by offering paid work. Queen Mary provides various types of employment in vacation and term time – from assisting with conferences to working in QMSU’s bar, cafés and restaurants. Postgraduates are often particularly attracted to stewarding work, where College accommodation on campus is provided at a reduced rate in return for residential supervision duties. For more information about catering or stewarding work, please contact: Student and Campus Services Business Support Tel: +44 (0)20 7882 8615/7669 email: scsbusinesssupport@qmul.ac.uk All jobs offered by the College have rates of pay that are competitive with other local employers, and students can rest assured that they will not be exposed to unsafe conditions, unreasonable hours or unpleasant working environments. Further details are also available from the Students’ Union.

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Financial advice and guidance Our experienced Welfare Advisers have specialist training to offer you professional advice on a range of financial issues. Our aim is to advise you about possible financial solutions and options, so that you can concentrate on your academic progress. Most of our work is about helping you with your rights and entitlements, including: • postgraduate funding • financial support for student parents (childcare costs etc) • fee status • planning a budget • dealing with debt

• welfare benefits and tax credits

Further information

• hardship funds

If you have any queries about tuition fees or the scholarships and bursaries available through Queen Mary, please don’t hesitate to contact us:

• funding from trusts and charities • council tax As well as helping you to find solutions to problems, we can give you information and advice to help you to avoid problems before they happen. We can also give you advice before you start your studies. For example, we can help you to plan a budget, and check that you are getting all the funding that you are entitled to. We can offer you advice by telephone if you cannot attend in person: Tel: +44 (0)20 7882 8717 www.welfare.qmul.ac.uk

Admissions and Recruitment Office Queen Mary, University of London Mile End Road London E1 4NS Tel: +44 (0)20 7882 5533 email: bursaries@qmul.ac.uk

International students and English language requirements

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International students and English language requirements

English language requirements All tuition and examinations at the College are in English, so a sound command of the language is essential for success in any course of study, or when following a research degree. Queen Mary provides a number of programmes in English for academic purposes to help international students get the most out of their study. You need to be able to cope with reading, note taking from lectures, books, journals and other materials; to speak well in seminars, discussions groups and tutorials; and to present yourself effectively in written assignments and examinations. If your first language is not English, you must provide evidence that your English skills are sufficient by including with your application details of recognised language qualifications

and experience in using the language. The table below shows the minimum English language requirements for each degree programme. Applicants who score slightly below the required IELTS band may be offered a place on condition that they attend a presessional English language summer programme. For further information see www.languageandlearning.qmul. ac.uk/elss/presessional. You will also be able to work on your English language skills after you have arrived at Queen Mary. There are a number of classes offering opportunities to practice your grammar and vocabulary, speaking and listening skills. For more information see: www.qmul.ac.uk/international/ englishlanguagecourses/index. html

Academic study support To help students with the transition to higher degree study, the Language and Learning Unit runs an programme of short courses, tutorials and drop-in classes in such skills as organisation and time management, research and notetaking, oral communication and presentation, academic writing, personal development planning and revision and examination skills. For more information about English Language and Academic Study programmes contact: English Language and Study Skills office Tel: +44 (0)20 7882 2827 Fax: +44 (0)20 8983 5857 email: elss@qmul.ac.uk www.languageandlearning.qmul. ac.uk/elss

English language test scores IELTS

TOEFL

CBTOEFL

IBTOEFL

Aesthetic Surgery

610

253

100

Analytical Toxicology

610

253

100

Burn Care

610

253

100

Cancer Therapeutics

610

253

100

Clinical Dermatology

6.5

580

237

Clinical Drug Development

610

253

100

Clinical Microbiology

610

253

100

Endocrinology and Diabetes

610

253

100

Forenisic Medical Sciences

610

253

100

6.5

580

237

Gastoenterology

134 Barts and The London School of Medicine and Dentistry

International students and English language requirements

English language test scores

Health Care Research Methods

IELTS

TOEFL

CBTOEFL

IBTOEFL

610

253

100

Inflamation: Cellular and Vascular Aspects

610

253

100

Mental Health: Psychological Therapies

610

253

100

Mental Health: Transcultural Mental Healthcare

610

253

100

Molecular Pathology and Genomics

610

253

100

Non Invasive Aesthetic Techniques

610

253

100

Operative Gynaecology and Minimally Invasive Skills

6.5

580

237

Operative Orthopaedic and Arthroscopic Skills

6.5

580

237

610

253

100

Primary Care Public Health

610

253

100

Sports and Exercise Medicine

6.5

580

237

Surgical Skills and Sciences

6.5

580

237

Translational Neuroscience

6.5

580

237

International students Queen Mary offers a cosmopolitan graduate community, with students from all over the world making a valuable and active contribution to academic and social life. Whether you have studied in England before, or whether this will be a new experience for you, you will find a warm welcome at the College. We offer a range of support services to help our international students feel at home. Airport collection New international students are offered a free airport collection service before the start of term in September 2011. This service will be advertised on our website along with an online booking form: www.qmul.ac.uk/prearrival/

The welcome programme A welcome programme is provided for all new international students before the start of term in September 2011. This is an opportunity to meet other international students studying a variety of programmes and gain practical advice about studying and living in London. Advice and counselling The Advice and Counselling Service offers professional advice and support to international students throughout your time here. We can advise you on finance and funding, visa extension issues, immigration requirements, UK work schemes after study, and offer counselling support for personal/emotional issues. We also organise a range of events through the year

especially for international students at Queen Mary. Aside from the welcome programme, these include various social events such as visits to other parts of the UK and information sessions to help you make the most out of your time here. See: www.welfare.qmul.ac.uk As a member of the international community at Queen Mary, you will automatically have membership of International Studentsâ&#x20AC;&#x2122; House (ISH) in central London. ISH offers a wide range of services to international students including advice on travel, accommodation and an extensive social programme. For details of these and other services please see the ISH website: www.ish.org.uk

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Healthcare There is a Student Health Service on campus. You (and your spouse and children if they are in the UK with you as your dependants) are entitled to free medical treatment on the UK National Health Service (NHS) if you are registered on a programme lasting six months or longer. If your programme lasts for less than six months, you should make sure you have adequate medical insurance cover. If you are an EEA national, you should obtain a European Health

Insurance Card (EHIC) before coming to the UK, which entitles you and your family to full NHS treatment. For more information, please visit our website: www.studenthealth.qmul.ac.uk Representatives in your country In many countries we have offices or educational representatives, who you can visit to discuss applying to Queen Mary. Contact details can be found at www.qmul.ac.uk/international/ countries/

International Office Members of staff at Queen Mary, regularly make visits overseas to meet with students and academic institutions. For more information on any aspect of life at Queen Mary as an international student, please see www.qmul.ac.uk/international/ events or contact us: International Office Tel: +44 (0)20 7882 3066 email: internationaloffice@qmul.ac.uk www.qmul.ac.uk/international

Campus life and accommodation

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Campus life and accommodation

We are a campus university with several different campuses across east and central London. The largest campus, at Mile End, houses most non-medical departments, as well as excellent student accommodation. The School of Medicine and Dentistry is largely based at our Whitechapel, Charterhouse Square and West Smithfield sites. Next to The Royal London Hospital, the Whitechapel campus is home to the impressive Blizard Building, which provides state of the art facilities for students and staff with open-plan research laboratories, office space, a lecture theatre and a café. The building also contains a unique interactive science centre, Centre of the Cell, for local school children, parents and teachers. Based in the City of London close to the Barbican, the Charterhouse Square and West Smithfield campuses are five minutes walk and on the site of St Bartholomew's Hospital respectively. Charterhouse Square hosts the Genome Centre, the William Harvey Research Institute, the Institute of Cancer and the Wolfson Institute of Preventive Medicine. Dawson Hall, one of the College's halls of residence is based here, as well as a student bar, multi gym and squash courts.

Accommodation Finding suitable accommodation while studying at Queen Mary is relatively easy. The College’s own facilities are both extensive and competitively priced. The College’s Student Village is the only self-contained campus in central London. All accommodation is in self-catered houses, flats and maisonettes. Queen Mary students also have access to places in the fully catered Intercollegiate Halls in central London, which are owned by the University of London. Additionally, there is a range of private sector housing in the east London area surrounding the campus. If you’d prefer to live in private accommodation, the College can help you find a suitable place, by providing you with guidance notes and up-todate listings of available properties. Please note, you need to be in London to commence your search, as pre-booking from overseas is not advised. Viewing the accommodation and negotiating a suitable contract is essential. Once you have firmly accepted your offer to study at Queen Mary, full details of how to apply for College housing will be sent to you by the Admissions Office. Some residences are reserved solely for postgraduates, while others may be shared with final year undergraduate students; all residences are for both male and female students. Single sex

accommodation is available in the non-en-suite style of housing, subject to availability.

Rent scales and information The prices quoted relate to Session 10/11 and are reviewed annually.

Queen Mary Student Village and Halls of Residence Rents for single rooms range from £88-£119 a week, inclusive of gas and electricity bills. Accommodation rents are payable each term in advance and are reviewed annually. The licence agreements are for a 38-week continuous period from the beginning of the academic year. If your programme continues over the summer vacation period, you will have the opportunity to extend your licence agreement. We offer housing between June and September, subject to availability, but you may be required to transfer from your original hall of residence into another one.

University Intercollegiate Halls of Residence About 200 Queen Mary students live in the University of London’s Intercollegiate Halls in central London, alongside students from other London colleges. Rents for single rooms are from £130 per week, inclusive of breakfast, evening meals and all gas and electricity bills.

138 Barts and The London School of Medicine and Dentistry

Campus life and accommodation

Privately-rented accommodation

Family accommodation

Once settled in London, many postgraduate students prefer the independent lifestyle offered by sharing flats or houses with friends. The Residences Office can provide advice, information and up-to-date listings of privately owned accommodation available for rent. Information can also be found on individual room lettings or homestay accommodation.

If you have a family, we would strongly advise you not to bring your partner or children to live in London until you have secured suitable, affordable housing. There is very little university or hostel accommodation for students with families, and housing in the private sector can be very expensive.

Contact Full details of the accommodation options for postgraduates can be found on our website.

Normal office hours are 9am-5pm throughout the year, except weekends and UK Bank Holidays. For all enquiries about accommodation: The Residences Office Student and Campus Services Queen Mary, University of London Mile End Road London E1 4NS Tel: +44 (0)20 7882 5522 email: residences@qmul.ac.uk www.residences.qmul.ac.uk

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Useful Queen Mary websites

You can find out more about student life at Queen Mary online. We’ve put together a list of the most useful websites below. Advice and Counselling Service www.welfare.qmul.ac.uk Disability and Dyslexia Service www.dds.qmul.ac.uk Application forms www.qmul.ac.uk/postgrad/ pgapplyq.shtml Careers Service www.careers.qmul.ac.uk Faith www.faith.qmul.ac.uk www.qm-mfc.co.uk

Occupational Health Service (OHS) www.ohs.qmul.ac.uk Residential Services www.residences.qmul.ac.uk Students’ Union www.qmsu.org Student Health Service www.studenthealth.qmul.ac.uk

Other useful websites Greater London Authority www.london.gov.uk International Students’ House (ISH) www.ish.org.uk

International office www.qmul.ac.uk/international/

The National Union of Students (NUS) www.nusonline.co.uk

Nursery www.nursery.qmul.ac.uk

Student Travel Association (STA) www.statravel.co.uk

Transport for London www.tfl.gov.uk University of London Union (ULU) www.ulu.co.uk

140 Barts and The London School of Medicine and Dentistry

Programme index

Advanced Mental Health Assessment Aesthetic Surgery Analytical Toxicology

Gastroenterology 118 32 102

Burn Care

Cancer Therapeutics

Clinical Dermatology

Clinical Drug Development

102

Clinical Microbiology

Dental Clinical Services

Dental Public Health

Dental Technology

Endocrinology and Diabetes

103

Endodontic Practice

Experimental Oral Pathology (Oral Sciences)

Forensic Medical Sciences

104

Health Care Research Methods Implant Dentistry Inflamation: Cellular and Vascular Aspects Mental Health: Psychological Therapies

34 102 68 106 118

Mental Health: Transcultural Mental Healthcare 118 Molecular Pathology and Genomics

Non Invasive Aesthetic Techniques

Operative Gynaecology and Minimally Invasive Skills

Operative Orthopaedic and Arthroscopic Skills

Oral Biology

Oral Medicine

Oral Surgery

Orthodontics

Paediatric Dentistry

Periodontology

Primary Care

Prosthodontics

Public Health

Sports and Exercise Medicine 85 Surgical Skills and Science

Translational Neuroscience

WWW.SMD.QMUL.AC.UK

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This guide has been produced by the Publications and Web Office for Barts and The London School of Medicine and Dentistry - Pub6087 Queen Mary, University of London Mile End Road London E1 4NS Freephone: 0800 376 1800 If calling from outside the UK: Tel: +44 (0)20 7882 5533 Fax: +44 (0)20 7882 5588 email: pgsmd@qmul.ac.uk

The information given in this prospectus is correct at the time of going to press. The College reserves the right to modify or cancel any statement in it and accepts no responsibility for the consequences of any such changes. This prospectus has been printed on environmentally friendly material from sustainable sources using non-solvent inks Any section of this publication is available upon request in accessible formats (large print, audio, etc.). For further information and assistance, please contact: Diversity Specialist, hr-equality@qmul.ac.uk, 020 7882 5585