What is IGF-1?
Overview of IGF-1 IGF-1 (Insulin-like growth factor 1), also called Somatomedin 1, IGF-I, IGFI, IGF1, IGF-IA, and mechano growth factor, was named for its close resemblance to proinsulin. IGF-1 is encoded by the IGF1 gene. IGF-1 is comprised of 70 amino acids with a molecular weight of 7649 Da. It’s amino acid sequence is GPETLCGAEL VDALQFVCGD RGFYFNKPTGYGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA. It is known as an important peptide for growth throughout the lifecycle of mammals.
How it Works IGF-1 is most commonly generated by the liver in response to production of growth hormone by the pituitary gland, but it can be produced in the fetus and other tissues for localized purposes. It has been shown to play a critical role in cell growth, apoptosis (programmed cell death), cell division, and the transfer of glucose across cell membranes. Interestingly, it is found to have the opposite effect on adipose (fat) tissue. IGF-1 inhibits the growth of adipose tissue while restricting glucose transport which encourages the body to burn adipose tissue for energy.
About IGF-1 LR3 Long arginine 3-IGF-1, also called Long r3 IGF-1, LR3 IGF, IGF1 LR3, LongArg3 IGF1, is a synthetic version of IGF-1. It differs from IGF-1 by having an additional 13 amino acids at its N-terminus making it 83 amino acids. There is also a substitution in the corresponding IGF-1 third position of glutamic acid for an arginine. It has a molecular weight of 9105.4 Da. It’s amino acid sequence is MFPAMPLSSL FVNGPRTLCG AELVDALQFVCGDRGFYFNK PTGYGSSSRR APQTGIV DEC CFRSCDLRRL EMYCAPLKPA KSA. The difference in chemical composition makes the ability to bind to IGF proteins less efficient. The result is a 2.5 times increase in potency. Additionally, it has a prolonged half-life of 20-30 hours.
About IGF-1 DES DES (1-3) IGF-1, also named IGF-1 Des (1-3), IGF-1 Des 1-3, is another type of IGF-1 that occurs naturally and synthetically. It is missing the first three amino acids from the IGF-1 amino acid chain. It is composed of 67 amino acids and has a molecular weight of 7360.5 Da. The amino acid sequence is TLCGAELVDA LQFVCGDRGF YFNKPTGYGS SSRRAPQTGIVDECCFRSCD LRRLEMYCAP LKPAKSA. The missing amino acids make it less effective at binding to IGF proteins, mostly because of the glutamate amino acid missing from position 3. The structural difference makes it 10x more potent than IGF-1.
Get Started on Researching IGF-1, and its variants, are essential for regular growth in mammals and the development of muscle mass later in life. They have wide clinical use to treat or induce different physical and muscle developmental issues. Rasa Research is proud to be provide these peptides for purchase for research purposes only.
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