MediPoint: Neurovascular Interventions - Global Analysis and Market Forecasts

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MediPoint: Neurovascular Interventions - Global Analysis and Market Forecasts Published on April 2014

Report Summary MediPoint: Neurovascular Interventions - Global Analysis and Market Forecasts Summary The global neurovascular interventions market is a vast, double-digit market that consists of innovative and emerging technologies. Rapid advances in the field of neurovascular interventions and development of minimally invasive techniques have greatly expanded the potential of therapeutic applications. The neurovascular interventions market consists of four device segments including embolization, revascularization, mechanicalthrombectomy and access/support devices. Embolization devices including bare metal and bioactive/coated coils, aneurysm remodeling devices (stents and occlusion balloons), flow diversion devices and liquid embolic agents can be used to treat intracranial aneurysms and arteriovenous malformations (AVMs) and optimize outcomes. Low-profile stent and balloon systems can be used to revascularize plaque burdened arteries in the cerebrovasculature. Mechanical thrombectomy devices including distal and proximal devices and stent retrievers can improve recanalization rates and provide predictable outcomes in the setting of acute ischemic stroke (AIS). In addition, the next generation of access/support devices has been developed to improve navigation, trackability and flexibility as well as provide stable access, especially through tortuous anatomy. This report focuses on the global neurovascular interventions market in the 10 major markets (10MM) (US, France, Germany, Italy, Spain, UK, Japan, China, India, and Brazil) for treating cerebrovascular disease including intracranial aneurysms and AVMs, atherosclerotic disease, and AIS. The global neurovascular interventions market is determined for the 10 countries covered in this report and provides insight into the competitive landscape, the marketed and pipeline products, the current and emerging players and market analysis of the different device segments within the neurointerventional market. The report identifies the unmet needs in the market while providing an understanding of physicians' perceptions and decision-making processes in using neurointerventional devices; this report also evaluates the adoption of various neurointerventional devices in the future. Highlights Key Questions Answered - The neurovascular interventions market is expected to continue its growth through the forecast period. (Q).What are the primary patient segments, indications and different product offerings in the neurovascular interventions market' - Endovascular therapy for cerebrovascular applications has seen rapid development in materials research and new techniques for treatment. (Q).What specific technologies/device segments will drive the market ' (Q).What are the future trends and drivers for growth in the market' - Innovative technologies such as flow diverters and stent retrievers have been developed to treat challenging indications. (Q).Is flow diversion a viable alternative for patients with complex aneurysms' (Q).Will stent retrievers continue to be adopted widely in clinical practice in the future' (Q).Do we see pricing pressure in the neurointerventional devices' - Stenting and balloon angioplasty is primarily performed in the setting of carotid artery stenosis. (Q).What is the market potential for revascularization devices' (Q).What is the market outlook for endovascular stenting for atherosclerotic disease'

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>> Get this Report Now by email! - The top players in this market have developed a broad and comprehensive portfolio of neurointerventional devices for various cerebrovascular indications. (Q).What role do smaller players have in grabbing market share in the different global regions' (Q).Who are the key players in the neurovascular interventional market' Scope - Overview of cerebrovascular disease, including epidemiology, pathophysiology, symptoms, diagnosis, and treatment guidelines and modalities. - Annualized total neurovascular interventions market revenue by device segment, annual cost of disease and neurointerventional devices adoption pattern and procedure data from 2011-2013 and forecast for seven years to 2020. - Key topics covered include strategic competitor assessment, market characterization, identification of unmet needs, reimbursement and regulatory considerations, evaluating market access in each region covered in the report, and implications of the neurovascular interventions market. - Pipeline analysis: Comprehensive data split across different stages of development, emerging trends and device designs in development. - Analysis of the current and future market competition in the global neurovascular interventions market. Insightful review of the key industry drivers, opportunities, restraints and challenges. Each trend is independently researched to provide qualitative analysis of its implications. Reasons to buy - Develop and design your in-licensing and out-licensing strategies through a review of pipeline products and technologies, and by identifying the companies with the most robust pipeline. - Develop business strategies by understanding the trends shaping and driving the global neurovascular interventions market. - Drive revenues by understanding the key trends, innovative products and technologies, market segments, and companies likely to impact the global neurovascular interventions market in the future. - Formulate effective sales and marketing strategies by understanding the competitive landscape and by analyzing the performance of various competitors. - Identify emerging players with potentially strong product portfolios and create effective counter-strategies to gain a competitive advantage. - Track device sales in the global and country-specific neurovascular interventions market from 2011-2020. - Organize your sales and marketing efforts by identifying the market categories and segments that present maximum opportunities for consolidations, investments and strategic partnerships.

Table of Content 2 Introduction 31 2.1 Catalyst 32 3 Clinical Outcomes 34 3.1 Disease Management 34 3.1.1 Intracranial Aneurysms 34 3.1.2 Intracranial Arteriovenous Malformations 35 3.1.3 Dural Arteriovenous Fistulas 36 3.1.4 Intracranial and Extracranial Atherosclerotic Disease 36 3.1.5 Stroke 37 3.2 Treatment Modalities 38

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>> Get this Report Now by email! 3.2.1 Overview 38 3.2.2 Medical/Chemical Therapy 39 3.2.3 Surgical Therapy 40 3.2.4 Endovascular Therapy 42 4 Industry Overview 53 4.1 Overview 53 4.2 Procedure Trends 53 4.2.1 Intracranial Aneurysms 53 4.2.2 Intracranial Arteriovenous Malformations 59 4.2.3 Atherosclerotic Disease 60 4.2.4 Acute Ischemic Stroke 65 4.3 Market Access 68 4.3.1 Regulatory Process 70 4.3.2 Physician Perception and Decision Making Process 76 4.3.3 Variations in Clinical Practice 82 4.3.4 Lack of Clinical Data 82 4.3.5 Regional-Level Control 83 4.3.6 Cost-Considerations 84 4.3.7 Reimbursement Trends 89 4.4 Regulatory Issues/Recalls 98 4.4.1 Regulatory Issues 98 4.4.2 Product Recalls 99 4.5 Mergers and Acquisitions/Key Partnerships 99 4.5.1 Covidien and Nfocus Neuromedical 99 4.5.2 Stryker Corporation and Surpass Medical 100 4.5.3 Covidien and MindFrame 100 4.5.4 Covidien and Reverse Medical Corporation 100 4.5.5 Stryker Corporation and Boston Scientific Neurovascular 101 4.5.6 Stryker Corporation and Concentric Medical 101 4.5.7 Covidien and ev3 102 4.5.8 Medtronic and Invatec 102 4.5.9 Johnson & Johnson and Micrus Endovascular 102 4.5.10 ev3 and Chestnut Medical Technologies 103 4.5.11 Boston Scientific Corporation and Guidant Corporation 103 4.6 Economic Impact 104 4.6.1 Economic Impact of Intracranial Aneurysms and Arteriovenous Malformations 104 4.6.2 Economic Impact of Stroke 105 4.6.3 Treatment Costs of Cerebrovascular Disease 106 5 Unmet Needs 110 5.1 Overview 110 5.2 Need for Practice, Performance, and Physician Training Guidelines 110 5.3 Lack of Clinical Data 111 5.4 Improve Management of Acute Ischemic Stroke 112 5.5 Address Complications of Surgical Therapy 114 5.6 Addressing the Challenges of Surgical Clipping 114 5.7 Lack of Optimal Treatment Strategy for Unruptured Intracranial Aneurysms 115 5.8 Need for Effective Therapies for Complex Aneurysm Morphologies and Sizes 116 5.9 Difficulty in Treating Intracranial Arteriovenous Malformations 117

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>> Get this Report Now by email! 5.10 Eliminating Mechanisms of Failure with Balloon Angioplasty 118 5.11 Addressing Challenges of Neurovascular Stenting 119 5.11.1 Risk of Post-Procedural Complications 119 5.11.2 In-Stent Restenosis 120 5.11.3 Stent Navigation 120 5.12 Complications of Dual Antiplatelet Therapy 120 5.13 Need to Improve Medical Therapy 121 5.14 Improve Ease of Access 122 6 Market Opportunity Analysis 123 6.1 Neurovascular Interventions Market 123 6.2 Improve Neurointerventional Device Design 123 6.3 Challenges in Treating Complex Intracranial Aneurysms and Arteriovenous Malformations 125 6.3.1 Intracranial Aneurysms 125 6.3.2 Intracranial Arteriovenous Malformations 126 6.4 Target Challenging Patient Populations 127 6.5 Optimize Care for Acute Ischemic Stroke Patients 127 6.6 Development of Drug-Eluting Devices 129 6.7 Emerging Markets 129 7 Market Drivers and Barriers 131 7.1 Market Drivers 131 7.1.1 Rising Prevalence of Disease 132 7.1.2 Improved Clinical Outcomes with Endovascular Coiling 133 7.1.3 Remodeling Techniques with Stent and Balloon-Assisted Coiling 134 7.1.4 Viable Therapeutic Option for Challenging/Complex Intracranial Aneurysms 136 7.1.5 Alternative Non-Coiling Embolization Devices for Aneurysm Treatment 137 7.1.6 Endovascular Embolization of Intracranial Arteriovenous Malformations 138 7.1.7 Imaging Assessment for Intracranial Arteriovenous Malformation Treatment 139 7.1.8 Stenting for Carotid Atherosclerotic Disease 139 7.1.9 Low-Profile Stent Systems 140 7.1.10 Improved Recanalization Rates with Mechanical Thrombectomy Devices 141 7.1.11 Cost Savings 143 7.1.12 Availability of Long-Term and Cost-Effective Data 143 7.2 Market Barriers 144 7.2.1 Complications of Neurointerventional Procedures and Devices 144 7.2.2 Lack of Clinical Data 150 7.2.3 High Cost of Treatment 150 7.2.4 Lack of Reimbursement 152 7.2.5 Lack of Superiority of Bioactive/Coated Coils 153 7.2.6 Alternative Technologies for Stroke Therapy 154 7.2.7 Regulatory Challenges: US Food and Drug Administration and European Conformity Mark 154 7.2.8 Healthcare Cost-Cutting and Reimbursement 155 7.2.9 Availability of Venture Capital 156 7.2.10 Medical Device Excise Tax 157 8 Competitive Assessment 158 8.1 Overview 158 8.2 Global Market Share 158 8.3 Marketed Products 159 8.3.1 Aachen Resonance 159

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>> Get this Report Now by email! 8.3.2 Abbott Vascular 161 8.3.3 Acandis 163 8.3.4 B. Braun 166 8.3.5 BALT Extrusion 167 8.3.6 Blockade Medical 172 8.3.7 Boston Scientific Corporation 173 8.3.8 Contego Medical 175 8.3.9 Cook Medical 175 8.3.10 Covidien 176 8.3.11 Gardia Medical 183 8.3.12 Gore Medical 184 8.3.13 InspireMD 186 8.3.14 ITGI Medical 187 8.3.15 Johnson & Johnson 188 8.3.16 Medikit 194 8.3.17 Medtronic 196 8.3.18 Merlin MD 199 8.3.19 MicroPort Scientific Corporation 200 8.3.20 Minvasys 202 8.3.21 Neuravi 203 8.3.22 Optimed 204 8.3.23 Penumbra 206 8.3.24 Phenox GmbH 209 8.3.25 Reverse Medical 211 8.3.26 Sequent Medical 213 8.3.27 Stryker Neurovascular Intervention 215 8.3.28 Terumo Corporation 222 8.3.29 Valor Medical 230 9 Pipeline Assessment 232 9.1 Overview 232 9.2 Pipeline by Stage of Development 232 9.3 Product Profiles 234 9.3.1 Aneurysm Occlusion Saddle 234 9.3.2 Ballstent Microcatheter 235 9.3.3 Blood Clot Removing Device 235 9.3.4 EKOS' EkoSonic Small Vessel Endovascular System 236 9.3.5 Flow-Diverting Thin-Film Nitinol Covered Stent 236 9.3.6 Ischemic Stroke System 237 9.3.7 Janjua Aneurysm Net 238 9.3.8 Multilayer Aneurysm Repair System 238 9.3.9 NAVIMAX 239 9.3.10 Palmaz Scientific Stents 240 9.3.11 Silk Road System 241 9.3.12 Transcranial Thrombectomy Catheter 242 10 Clinical Trial Analysis 243 10.1 Overview 243 10.2 Clinical Trials to Watch 244 10.2.1 Embolization 244

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>> Get this Report Now by email! 10.2.2 Flow Diversion 246 10.2.3 Revascularization 249 10.2.4 Mechanical Thrombectomy 250 11 Current and Future Players 253 11.1 Overview 253 11.2 Trends in Corporate Strategy 253 11.3 Company Profiles 255 11.3.1 BALT Extrusion 255 11.3.2 Covidien 258 11.3.3 Johnson & Johnson 261 11.3.4 Penumbra 266 11.3.5 Stryker Corporation 269 11.3.6 Terumo Corporation 271 11.3.7 Abbott Vascular 275 11.3.8 Boston Scientific Corporation 277 11.3.9 Cook Medical 279 11.3.10 Gore Medical 281 11.3.11 Medtronic 283 11.3.12 Aachen Resonance 285 11.3.13 Acandis 287 11.3.14 B. Braun 290 11.3.15 Blockade Medical 291 11.3.16 Contego Medical 293 11.3.17 Gardia Medical 294 11.3.18 InspireMD 296 11.3.19 ITGI Medical 298 11.3.20 Medikit 299 11.3.21 Merlin MD 300 11.3.22 MicroPort Scientific Corporation 302 11.3.23 Minvasys 303 11.3.24 Neuravi 305 11.3.25 Optimed 306 11.3.26 Phenox GmBH 308 11.3.27 Reverse Medical 309 11.3.28 Sequent Medical 311 11.3.29 Valor Medical 312 11.3.30 Other Companies 315 12 Market Outlooks 317 12.1 By Market Segment 317 12.1.1 Embolization Device Market 319 12.1.2 Revascularization Device Market 323 12.1.3 Mechanical Thrombectomy Device Market 326 12.1.4 Access/Support Device Market 329 12.2 By Geography 331 12.2.1 Global Overview 331 12.2.2 United States 332 12.2.3 The Five European Union Markets 339 12.2.4 The Asia-Pacific Region 367

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>> Get this Report Now by email! 12.2.5 South America 386 13 Appendix 393 13.1 Bibliography 393 13.2 Abbreviations 417 13.3 Report Methodology 423 13.3.1 Overview 423 13.3.2 Coverage 423 13.3.3 Secondary Research 423 13.4 Physicians and Specialists Included in this Study 424 13.4.1 Vivek Gupta, MD 424 13.4.2 Zsolt Kulscรกr, MD, PhD 424 13.4.3 Salvatore Mangiafico, MD 424 13.4.4 Thanh Nguyen, MD, FRCPc 424 13.4.5 Eduardo Wajnberg, MD 425 13.4.6 Phil White, MD 425 13.4.7 Osama O Zaidat, MD, MS, FAAN, FAHA 425 13.5 Primary Research 425 13.5.1 Primary Research - Key Opinion Leader Interviews 425 13.5.2 Expert Panel Validation 426 13.6 Forecasting Methodology 427 13.7 About the Authors 429 13.7.1 Analysts 429 13.7.2 Global Head of Healthcare 430 13.8 About MediPoint 431 13.9 About GlobalData 431 13.10 Disclaimer 431 1.1 List of Tables Table 1: Complications of Cerebral Artery Bypass Surgery 41 Table 2: Types of Cerebral Embolic Protection Devices 49 Table 3: Medicare National Average of Inpatient Hospital Payment for Neurovascular Interventions, 2013-2014 90 Table 4: Reimbursement Classification of Medical Devices in Japan 95 Table 5: US Mean Hospital Costs* for Treating Cerebrovascular Disease, 2011-2020 ($US) 106 Table 6: Aachen Resonance Neurovascular Intervention Marketed Product 159 Table 7: Aachen Resonance Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 161 Table 8: Abbott Vascular Neurovascular Intervention Marketed Products 162 Table 9: Abbott Vascular Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 163 Table 10: Acandis Neurovascular Intervention Marketed Products 164 Table 11: Acandis Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 165 Table 12: B. Braun Neurovascular Intervention Marketed Product 166 Table 13: B. Braun Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 166 Table 14: BALT Extrusion Neurovascular Intervention Marketed Products 168 Table 15: BALT Extrusion Neurovascular Intervention Marketed Access Products 170 Table 16: BALT Extrusion Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 171 Table 17: Blockade Medical Neurovascular Intervention Marketed Product 172 Table 18: Blockade Medical Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 173 Table 19: Boston Scientific Neurovascular Intervention Marketed Products 174

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>> Get this Report Now by email! Table 20: Boston Scientific Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 174 Table 21: Contego Medical Neurovascular Intervention Marketed Product 175 Table 22: Contego Medical Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 175 Table 23: Cook Medical Neurovascular Intervention Marketed Products 176 Table 24: Cook Medical Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 176 Table 25: Covidien Neurovascular Interventional Marketed Products 178 Table 26: Covidien Neurovascular Intervention Marketed Access Products 181 Table 27: Covidien Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 182 Table 28: Gardia Medical Neurovascular Intervention Marketed Product 183 Table 29: Gardia Medical Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 184 Table 30: Gore Medical Neurovascular Intervention Marketed Products 185 Table 31: Gore Medical Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 185 Table 32: InspireMD Neurovascular Intervention Marketed Product 186 Table 33: InspireMD Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 186 Table 34: ITGI Medical Neurovascular Intervention Marketed Product 187 Table 35: ITGI Medical Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 188 Table 36: Codman Neurovascular Marketed Embolization Products 189 Table 37: Codman Neurovascular Marketed Mechanical Thrombectomy and Access Products 191 Table 38: Codman Neurovascular's (Codman & Shurtleff) Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 192 Table 39: Cordis Corporation Marketed Neurointerventional Products 193 Table 40: Cordis Corporation Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 194 Table 41: Medikit Neurovascular Intervention Marketed Products 195 Table 42: Medikit Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 196 Table 43: Medtronic Neurovascular Intervention Marketed Products 197 Table 44: Medtronic Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 198 Table 45: Merlin MD Neurovascular Intervention Marketed Product 199 Table 46: Merlin MD Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 200 Table 47: MicroPort Scientific Corporation Neurovascular Intervention Marketed Products 201 Table 48: MicroPort Scientific Corporation Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 202 Table 49: Minvasys Neurovascular Intervention Marketed Product 203 Table 50: Minvasys Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 203 Table 51: Neuravi Neurovascular Intervention Marketed Product 204 Table 52: Neuravi Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 204 Table 53: Optimed Neurovascular Intervention Marketed Products 205 Table 54: Optimed Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 205 Table 55: Penumbra Neurovascular Intervention Marketed Products 206 Table 56: Penumbra Marketed Neurovascular Access Products 208 Table 57: Penumbra Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 209 Table 58: Phenox GmbH Neurovascular Intervention Marketed Products 210 Table 59: Phenox GmbH Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 211 Table 60: Reverse Medical Neurovascular Intervention Marketed Products 212 Table 61: Reverse Medical Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 213 Table 62: Sequent Medical Neurovascular Intervention Marketed Products 214 Table 63: Sequent Medical Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 215 Table 64: Stryker Neurovascular Intervention Marketed Products 217 Table 65: Stryker Neurovascular Intervention Marketed Mechanical Thrombectomy and Access Products 219 Table 66: Stryker Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 221 Table 67: Terumo Europe N.V. and Terumo Interventional Systems Marketed Neurointerventional Products 223

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>> Get this Report Now by email! Table 68: Terumo Corporation Neurovascular Product Portfolio SWOT Analysis, 2014 224 Table 69: MicroVention Neurovascular Intervention Marketed Products 226 Table 70: MicroVention Marketed Neurovascular Access Products 228 Table 71: MicroVention Neurovascular Product Portfolio SWOT Analysis, 2014 229 Table 72: Valor Medical Neurovascular Intervention Marketed Products 230 Table 73: Valor Medical Neurovascular Intervention Product Portfolio SWOT Analysis, 2014 231 Table 74: Global Neurovascular Interventions Pipeline Products 234 Table 75: Aneurysm Occlusion Saddle SWOT Analysis, 2014 235 Table 76: EKOS EkoSonic SV System SWOT Analysis, 2014 236 Table 77: Flow-Diverting Thin-Film Nitinol Covered Stent SWOT Analysis, 2014 237 Table 78: Janjua Aneurysm Net SWOT Analysis, 2014 238 Table 79: Multilayer Aneurysm Repair System SWOT Analysis, 2014 239 Table 80: NAVIMAX SWOT Analysis, 2014 240 Table 81: Palmaz Scientific Stents SWOT Analysis, 2014 241 Table 82: Silk Road System SWOT Analysis, 2014 242 Table 83: BALT Extrusion Company Profile 256 Table 84: BALT Extrusion Neurovascular Intervention Marketed Products 257 Table 85: BALT Extrusion SWOT Analysis, 2014 258 Table 86: Covidien Company Profile 259 Table 87: Covidien Neurovascular Intervention Marketed Products 260 Table 88: Covidien SWOT Analysis, 2014 261 Table 89: Codman & Shurtleff Company Profile 262 Table 90: Codman & Shurtleff Neurovascular Intervention Marketed Products 263 Table 91: Codman & Shurtleff SWOT Analysis, 2014 264 Table 92: Cordis Corporation Company Profile 264 Table 93: Cordis Corporation Neurovascular Intervention Marketed Products 265 Table 94: Cordis Corporation SWOT Analysis, 2014 266 Table 95: Penumbra Company Profile 266 Table 96: Penumbra Neurovascular Intervention Marketed Products 268 Table 97: Penumbra SWOT Analysis, 2014 268 Table 98: Stryker Corporation Company Profile 269 Table 99: Stryker Corporation Neurovascular Intervention Marketed Products 270 Table 100: Stryker Corporation SWOT Analysis, 2014 271 Table 101: Terumo Corporation Company Profile 272 Table 102: Terumo Europe N.V. and Terumo Interventional Systems Neurovascular Intervention Marketed Products 273 Table 103: MicroVention Neurovascular Intervention Marketed Products 274 Table 104: Terumo Corporation SWOT Analysis, 2014 275 Table 105: Abbott Vascular Company Profile 275 Table 106: Abbott Vascular Neurovascular Intervention Marketed Products 276 Table 107: Abbott Vascular SWOT Analysis, 2014 277 Table 108: Boston Scientific Corporation Company Profile 278 Table 109: Boston Scientific Neurovascular Intervention Marketed Products 278 Table 110: Boston Scientific Corporation SWOT Analysis, 2014 279 Table 111: Cook Medical Company Profile 279 Table 112: Cook Medical Neurovascular Intervention Marketed Products 280 Table 113: Cook Medical SWOT Analysis, 2014 281 Table 114: Gore Medical Company Profile 282 Table 115: Gore Medical Neurovascular Intervention Marketed Products 282

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>> Get this Report Now by email! Table 116: Gore Medical SWOT Analysis, 2014 283 Table 117: Medtronic Company Profile 284 Table 118: Medtronic Neurovascular Intervention Marketed Products 285 Table 119: Medtronic SWOT Analysis, 2014 285 Table 120: Aachen Resonance Company Profile 286 Table 121: Aachen Resonance Neurovascular Intervention Marketed Product 287 Table 122: Aachen Resonance SWOT Analysis, 2014 287 Table 123: Acandis Company Profile 288 Table 124: Acandis Neurovascular Intervention Marketed Products 289 Table 125: Acandis SWOT Analysis, 2014 289 Table 126: B. Braun Company Profile 290 Table 127: B. Braun Neurovascular Intervention Marketed Product 291 Table 128: B. Braun SWOT Analysis, 2014 291 Table 129: Blockade Medical Company Profile 292 Table 130: Blockade Medical Neurovascular Intervention Marketed Product 292 Table 131: Blockade Medical SWOT Analysis, 2014 293 Table 132: Contego Medical Company Profile 293 Table 133: Contego Medical Neurovascular Intervention Marketed Product 294 Table 134: Contego Medical SWOT Analysis, 2014 294 Table 135: Gardia Medical Company Profile 295 Table 136: Gardia Medical Neurovascular Intervention Marketed Product 295 Table 137: Gardia Medical SWOT Analysis, 2014 296 Table 138: InspireMD Company Profile 297 Table 139: InspireMD Neurovascular Intervention Marketed Product 297 Table 140: InspireMD SWOT Analysis, 2014 297 Table 141: ITGI Medical Company Profile 298 Table 142: ITGI Medical Neurovascular Intervention Marketed Product 298 Table 143: ITGI Medical SWOT Analysis, 2014 299 Table 144: Medikit Company Profile 299 Table 145: Medikit Neurovascular Intervention Marketed Products 300 Table 146: Medikit SWOT Analysis, 2014 300 Table 147: Merlin MD Company Profile 301 Table 148: Merlin MD Neurovascular Intervention Marketed Product 301 Table 149: Merlin MD SWOT Analysis, 2014 301 Table 150: MicroPort Scientific Corporation Company Profile 302 Table 151: MicroPort Scientific Corporation Neurovascular Intervention Marketed Products 302 Table 152: MicroPort Scientific Corporation SWOT Analysis, 2014 303 Table 153: Minvasys Company Profile 304 Table 154: Minvasys Neurovascular Intervention Marketed Product 304 Table 155: Minvasys SWOT Analysis, 2014 304 Table 156: Neuravi Company Profile 305 Table 157: Neuravi Neurovascular Intervention Marketed Product 305 Table 158: Neuravi SWOT Analysis, 2014 306 Table 159: Optimed Company Profile 307 Table 160: Optimed Neurovascular Intervention Marketed Products 307 Table 161: Optimed SWOT Analysis, 2014 307 Table 162: Phenox GmBH Company Profile 308 Table 163: Phenox GmbH Neurovascular Intervention Marketed Products 309

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>> Get this Report Now by email! Table 164: Phenox GmBH SWOT Analysis, 2014 309 Table 165: Reverse Medical Company Profile 310 Table 166: Reverse Medical Neurovascular Intervention Marketed Products 310 Table 167: Reverse Medical SWOT Analysis, 2014 311 Table 168: Sequent Medical Company Profile 311 Table 169: Sequent Medical Neurovascular Intervention Marketed Products 312 Table 170: Sequent Medical SWOT Analysis, 2014 312 Table 171: Valor Medical Company Profile 313 Table 172: Valor Medical Neurovascular Intervention Marketed Products 313 Table 173: Valor Medical SWOT Analysis, 2014 314 Table 174: Other Companies in the Neurovascular Intervention Market, 2014 315 Table 175: Global Embolization Device Market ($m) Forecast, 2011-2020 319 Table 176: Global Revascularization Device Market ($m) Forecast, 2011-2020 323 Table 177: Global Mechanical Thrombectomy Device Market ($m) Forecast, 2011-2020 326 Table 178: Global Access/Support Device Market ($m) Forecast, 2011-2020 329 Table 179: Neurovascular Interventions Market Sales ($m) Forecast for the US, 2011-2020 333 Table 180: Neurovascular Interventions Market Sales ($m) Forecast for France, 2011-2020 340 Table 181: Neurovascular Interventions Market Sales ($m) Forecast for Germany, 2011-2020 345 Table 182: Neurovascular Interventions Market Sales ($m) Forecast for Italy, 2011-2020 351 Table 183: Neurovascular Interventions Market Sales ($m) Forecast for Spain, 2011-2020 356 Table 184: Neurovascular Interventions Market Sales ($m) Forecast for the UK, 2011-2020 362 Table 185: Neurovascular Interventions Market Sales ($m) Forecast for Japan, 2011-2020 368 Table 186: Neurovascular Interventions Market Sales ($m) Forecast for China, 2011-2020 374 Table 187: Neurovascular Interventions Market Sales ($m) Forecast for India, 2011-2020 380 Table 188: Neurovascular Interventions Market Sales ($m) Forecast for Brazil, 2011-2020 387 1.2 List of Figures Figure 1: Treatment Modalities - Neurovascular Interventions 39 Figure 2: Types of Stents Used for Neurovascular Interventions 48 Figure 3: Embolization Procedure Volume for Treating Intracranial Aneurysms, US, 2011-2020 54 Figure 4: Embolization Procedure Volume for Treating Intracranial Aneurysms, 5EU, 2011-2020 56 Figure 5: Embolization Procedure Volume for Treating Intracranial Aneurysms, APAC, 2011-2020 57 Figure 6: Embolization Procedure Volume for Treating Intracranial Aneurysms, South America, 2011-2020 58 Figure 7: Embolization Procedure Volume for Treating Intracranial Arteriovenous Malformations, Global, 2011-2020 60 Figure 8: Revascularization Procedure Volume for Treating Atherosclerotic Disease, US, 2011-2020 61 Figure 9: Revascularization Procedure Volume for Treating Atherosclerotic Disease, 5EU, 2011-2020 62 Figure 10: Revascularization Procedure Volume for Treating Atherosclerotic Disease, APAC, 2011-2020 63 Figure 11: Revascularization Procedure Volume for Treating Atherosclerotic Disease, South America, 2011-2020 64 Figure 12: Mechanical Thrombectomy Procedure Volume for Treating Acute Ischemic Stroke, US, 2011-2020 65 Figure 13: Mechanical Thrombectomy Procedure Volume for Treating Acute Ischemic Stroke, 5EU, 2011-2020 66 Figure 14: Mechanical Thrombectomy Procedure Volume for Treating Acute Ischemic Stroke, APAC, 2011-2020 67 Figure 15: Mechanical Thrombectomy Procedure Volume for Treating Acute Ischemic Stroke, South America, 2011-2020 68 Figure 16: US Mean Hospital Costs* for Treating Intracranial Aneurysms and Arteriovenous Malformations, 2011-2020 ($US) 107 Figure 17: US Mean Hospital Costs* for Treating Extracranial and Intracranial Atherosclerotic Disease, 2011-2020 ($US) 108 Figure 18: US Mean Hospital Costs* for Treating Stroke, 2011-2020 ($US) 109 Figure 19: Global Neurointerventional Market Distribution, 2013 158 Figure 20: Global Neurovascular Interventions Pipeline Products by Stage of Development, 2014 233 Figure 21: Global Neurovascular Interventions Market ($bn) for Treating Cerebrovascular Disease, 2011-2020 317

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>> Get this Report Now by email! Figure 22: Distribution of Percentage of Patients Treated for Cerebrovascular Disease, Global, 2013 318 Figure 23: Global Embolization Device Market ($m) for Cerebrovascular Applications, 2011-2020 320 Figure 24: Global Embolization Device Market Distribution, 2013 and 2020 321 Figure 25: Global Revascularization Device Market ($m) for Cerebrovascular Applications, 2011-2020 324 Figure 26: Global Revascularization Device Market Distribution, 2013 and 2020 325 Figure 27: Global Mechanical Thrombectomy Device Market ($m) for Cerebrovascular Applications, 2011-2020 327 Figure 28: Global Mechanical Thrombectomy Device Market Distribution, 2013 and 2020 329 Figure 29: Global Access/Support Device Market ($m) for Cerebrovascular Applications, 2011-2020 330 Figure 30: Global Access/Support Device Market Distribution, 2013 and 2020 331 Figure 31: Global Neurovascular Interventions Market Revenue ($bn), 2013 and 2020 332 Figure 32: US Neurovascular Interventions Market ($m) for Cerebrovascular Applications, 2011-2020 334 Figure 33: US Embolization Device Market ($m) for Cerebrovascular Applications, 2011-2020 336 Figure 34: US Revascularization Device Market ($m) for Cerebrovascular Applications, 2011-2020 337 Figure 35: US Mechanical Thrombectomy Device Market ($m) for Cerebrovascular Applications, 2011-2020 338 Figure 36: US Access Device Market ($m) for Cerebrovascular Applications, 2011-2020 339 Figure 37: French Neurovascular Interventions Market ($m) for Cerebrovascular Applications, 2011-2020 340 Figure 38: French Embolization Device Market ($m) for Cerebrovascular Applications, 2011-2020 341 Figure 39: French Revascularization Device Market ($m) for Cerebrovascular Applications, 2011-2020 342 Figure 40: French Mechanical Thrombectomy Device Market ($m) for Cerebrovascular Applications, 2011-2020 343 Figure 41: French Access Device Market ($m) for Cerebrovascular Applications, 2011-2020 344 Figure 42: German Neurovascular Interventions Market ($m) for Cerebrovascular Applications, 2011-2020 345 Figure 43: German Embolization Device Market ($m) for Cerebrovascular Applications, 2011-2020 347 Figure 44: German Revascularization Device Market ($m) for Cerebrovascular Applications, 2011-2020 348 Figure 45: German Mechanical Thrombectomy Device Market ($m) for Cerebrovascular Applications, 2011-2020 349 Figure 46: German Access Device Market ($m) for Cerebrovascular Applications, 2011-2020 350 Figure 47: Italian Neurovascular Interventions Market ($m) for Cerebrovascular Applications, 2011-2020 351 Figure 48: Italian Embolization Device Market ($m) for Cerebrovascular Applications, 2011-2020 352 Figure 49: Italian Revascularization Device Market ($m) for Cerebrovascular Applications, 2011-2020 353 Figure 50: Italian Mechanical Thrombectomy Device Market ($m) for Cerebrovascular Applications, 2011-2020 354 Figure 51: Italian Access Device Market ($m) for Cerebrovascular Applications, 2011-2020 355 Figure 52: Spanish Neurovascular Interventions Market ($m) for Cerebrovascular Applications, 2011-2020 357 Figure 53: Spanish Embolization Device Market ($m) for Cerebrovascular Applications, 2011-2020 358 Figure 54: Spanish Revascularization Device Market ($m) for Cerebrovascular Applications, 2011-2020 359 Figure 55: Spanish Mechanical Thrombectomy Device Market ($m) for Cerebrovascular Applications, 2011-2020 360 Figure 56: Spanish Access Device Market ($m) for Cerebrovascular Applications, 2011-2020 361 Figure 57: UK Neurovascular Interventions Market ($m) for Cerebrovascular Applications, 2011-2020 362 Figure 58: UK Embolization Device Market ($m) for Cerebrovascular Applications, 2011-2020 364 Figure 59: UK Revascularization Device Market ($m) for Cerebrovascular Applications, 2011-2020 365 Figure 60: UK Mechanical Thrombectomy Device Market ($m) for Cerebrovascular Applications, 2011-2020 366 Figure 61: UK Access Device Market ($m) for Cerebrovascular Applications, 2011-2020 367 Figure 62: Japanese Neurovascular Interventions Market ($m) for Cerebrovascular Applications, 2011-2020 369 Figure 63: Japanese Embolization Device Market ($m) for Cerebrovascular Applications, 2011-2020 370 Figure 64: Japanese Revascularization Device Market ($m) for Cerebrovascular Applications, 2011-2020 371 Figure 65: Japanese Mechanical Thrombectomy Device Market ($m) for Cerebrovascular Applications, 2011-2020 372 Figure 66: Japanese Access Device Market ($m) for Cerebrovascular Applications, 2011-2020 373 Figure 67: Chinese Neurovascular Interventions Market ($m) for Cerebrovascular Applications, 2011-2020 375 Figure 68: Chinese Embolization Device Market ($m) for Cerebrovascular Applications, 2011-2020 376 Figure 69: Chinese Revascularization Device Market ($m) for Cerebrovascular Applications, 2011-2020 377

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>> Get this Report Now by email! Figure 70: Chinese Mechanical Thrombectomy Device Market ($m) for Cerebrovascular Applications, 2011-2020 378 Figure 71: Chinese Access Device Market ($m) for Cerebrovascular Applications, 2011-2020 379 Figure 72: Indian Neurovascular Interventions Market ($m) for Cerebrovascular Applications, 2011-2020 381 Figure 73: Indian Embolization Device Market ($m) for Cerebrovascular Applications, 2011-2020 383 Figure 74: Indian Revascularization Device Market ($m) for Cerebrovascular Applications, 2011-2020 384 Figure 75: Indian Mechanical Thrombectomy Device Market ($m) for Cerebrovascular Applications, 2011-2020 385 Figure 76: Indian Access Device Market ($m) for Cerebrovascular Applications, 2011-2020 386 Figure 77: Brazilian Neurovascular Interventions Market ($m) for Cerebrovascular Applications, 2011-2020 388 Figure 78: Brazilian Embolization Device Market ($m) for Cerebrovascular Applications, 2011-2020 389 Figure 79: Brazilian Revascularization Device Market ($m) for Cerebrovascular Applications, 2011-2020 390 Figure 80: Brazilian Mechanical Thrombectomy Device Market ($m) for Cerebrovascular Applications, 2011-2020 391 Figure 81: Brazilian Access Device Market ($m) for Cerebrovascular Applications, 2011-2020 392

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