ReportLinker
Find Industry reports, Company profiles and Market Statistics
>> Get this Report Now by email!
Transdermal Drug Delivery - Technologies, Markets, and Companies Published on September 2011
Report Summary This report deals with transdermal drug delivery - an approach used to deliver drugs through the skin for therapeutic use as an alternative to oral,intravascular, subcutaneous and transmucosal routes. Various transdermal drug delivery technologies are described including the use of suitable formulations, carriers and penetration enhancers. The most commonly used transdermal system is the skin patch using various types of technologies. Nanoparticles as well as the use of physical agents to facilitate transcutaneous drug delivery is described. Microneedle and needleless technologies are also described. Transdermal technologies may be applied for several categories of pharmaceuticals used for the treatment of disorders of the skin or for systemic effect to treat diseases of other organs. Several transdermal products and applications include hormone replacement therapy, contraception, management of pain, angina pectoris, smoking cessation and neurological disorders such as Parkinson's disease. The market for transdermal drug delivery is analyzed according to technologies and therapeutic areas from 2010 to 2020. This market is analyzed according to geographical regions as well.
Table of Content TABLE OF CONTENTS 0. Executive Summary 11 1. Basics of Transdermal Drug Delivery 13 Introduction 13 Historical landmarks in transdermal drug delivery 13 Anatomy and physiology of skin 14 Transcutaneous absorption 14 Transdermal versus other methods of drug delivery 14 Advantages of transdermal drug delivery 15 First-Pass Effect 15 Drawbacks of transdermal delivery 15 Factors that influence transdermal drug delivery 15 Events governing transcutaneous absorption 16 Properties of the skin 16 Properties of drugs 17 The role of pH and pharmacokinetics 17 Intradermal disposition of drugs after topical application 18 2. Transdermal Drug Delivery Technologies 19 Introduction 19 Local application formulations 20 Crystalline topical formulations 20 Microemulsions for transdermal drug delivery 20 Nanoemulsions for transdermal drug delivery 21 Transdermal gel technology 21
Transdermal Drug Delivery - Technologies, Markets, and Companies (From Issuu)
Page 1/9
ReportLinker
Find Industry reports, Company profiles and Market Statistics
>> Get this Report Now by email! Film forming polymeric solutions 22 Biphasix system 23 Penetration enhancers 23 Chemical enhancers 23 Nitric oxide-based transdermal drug delivery 25 Vesicular transdermal carriers 25 Liposomes 26 Transfersomes 26 Ethosomes 27 Elastic vesicles for transdermal drug delivery 27 Nanovesicles for transdermal drug delivery 28 Transdermal patches 28 Adhesives for transdermal patches 29 Commercial development of transdermal patches 30 Innovations in transdermal patches 31 e-Patch' controlled release micropump system 31 Patchless Transdermal Delivery System 31 Metered-dose transdermal system 32 Use of physical modalities to facilitate transdermal transport 32 Transdermal electrotransport 32 Electroporation 33 Drug delivery by electroporation 34 Cryoelectrophoresis 35 Iontophoresis 36 Iontophoresis compared with electrophoresis 36 Application of iontophoresis for drug delivery 36 Companies with technologies for drug delivery by iontophoresis 38 Combination of electrophoresis and iontophoresis 38 Dermaportation 39 Radiofrequency-driven transdermal delivery 39 Microporation 39 Transcutaneous drug delivery by electropulsation 40 Companies involved in electroporation-based drug delivery 40 Electrode Scanning System 41 Use of electrostatic force in skin patch technology 41 Multiple Absorption Kinetic System 41 Transdermal drug delivery facilitated by heat 42 Controlled, heat-aided drug delivery 42 Ultrasound 43 Magnetophoresis 44 Use of lasers for transdermal drug delivery 44 Transdermal drug delivery by laser-induced pressure waves 44 Transdermal drug delivery by laser-assisted changes in skin 45 Transdermal delivery by gas under pressure 46 Transdermal delivery with PowderJect gas gun 46 Microscission induced by gas 46 Microneedles and dermal microinjection technologies 46 Microneedle patch 47
Transdermal Drug Delivery - Technologies, Markets, and Companies (From Issuu)
Page 2/9
ReportLinker
Find Industry reports, Company profiles and Market Statistics
>> Get this Report Now by email! Microneedle arrays for drug delivery 48 MicroPyramid' hollow microneedles 48 Microstructured Transdermal Systems 48 Microneedle Array Patch technology 48 Macroflux microprojections technology 49 Companies developing microneedles for transdermal drug delivery 49 Needlefree injections 50 Glide SDI速 solid dose injector 50 Jet injection 50 Mini-Ject needlefree delivery system 50 MicroJet for painless injections 51 Nanoliter-volume pulsed microjets 51 SUMAVEL' DosePro' needle-less injection 51 Skin ablation or abrasion for drug delivery 52 Nanotechnology-based transdermal drug delivery 52 Nanoparticles and nanoemulsions for skin disorders 52 Transdermal nanoparticle preparations for systemic effect 53 Nanotechnology-based transdermal vaccination and immunotherapy 53 Delivery of nanostructured drugs from transdermal patches 54 NanoCyte transdermal drug delivery system 54 Effect of mechanical flexion on penetration of bucky balls through the skin 55 Safety issues of applications of nanomaterial carriers on the skin 55 Comparison of transdermal drug delivery systems 55 Role of microelectronics in transdermal drug delivery 55 Transdermal drug design 56 In vitro testing of transdermal drug delivery systems 56 In vivo testing of drug delivery systems 57 Infrared spectroscopy for evaluation of transdermal drug delivery 58 Modeling of transport through the skin 58 Concluding remarks on transdermal drug delivery technologies 59 Future developments in transdermal drug delivery 59 3. Transdermal Therapeutics 61 Introduction 61 Drugs that can be administered transdermally 61 Skin disorders 64 Psoriasis 64 Nanoemulsions for paclitaxel delivery in psoriasis 64 Iontophoresis for treatment of psoriasis 64 Hair loss 64 Cardiovascular disorders 65 Angina pectoris 65 Transdermal drug delivery for hypertension 66 Transdermal beta blockers 66 Transdermal anticoagulants 67 Congestive heart failure 67 Respiratory diseases 67 Asthma 67 Chronic obstructive pulmonary disease 68
Transdermal Drug Delivery - Technologies, Markets, and Companies (From Issuu)
Page 3/9
ReportLinker
Find Industry reports, Company profiles and Market Statistics
>> Get this Report Now by email! Neurological and psychiatric disorders 68 Parkinson's disease 68 Transdermal drug delivery for Parkinson's disease 69 Transdermal dopamine agonists for Parkinson's disease 69 Rotigotine 70 Transdermal administration of other drugs for Parkinson disease 72 Depression 72 Transdermal selegiline 72 Bipolar disorder 73 Transdermal lithium 73 Restless legs syndrome 73 Alzheimer's disease 73 Transdermal nicotine for Tourette syndrome 74 Attention deficit hyperactivity disorder 74 Transdermal methylphenidate 74 Migraine 75 Transdermal lidocaine 75 Transdermal sumatriptan 75 Epilepsy 76 Tinnitus/Vertigo 76 Transdermal nitroglycerin for vasospasm due to subarachnoid hemorrhage 76 Musculoskeletal disorders 76 Osteoporosis 76 Transdermal alendronate 77 Transdermal estrogen 77 Transdermal human parathyroid hormone 77 Osteoarthritis 77 Transdermal therapy of diabetes 78 Transdermal insulin delivery in diabetes 78 Transdermal GLP1 agonist 79 Male sexual disorders 79 Erectile dysfunction 79 Topical and transdermal preparation for erectile dysfunction 79 Hypogonadism in the male 80 Topical testosterone 80 Women's health 82 Female sexual arousal disorder 82 Menopause 82 Hormone replacement therapy for menopause 83 Effect of transdermal estradiol on bone density 84 Transdermal PTH for postmenopausal osteoporosis 85 Transdermal testosterone for low libido in postmenopausal women 85 Breast disorders 85 Dysmenorrhea 85 Female infertility 86 Contraception 86 Female contraception 86 Ortho Evra' 87
Transdermal Drug Delivery - Technologies, Markets, and Companies (From Issuu)
Page 4/9
ReportLinker
Find Industry reports, Company profiles and Market Statistics
>> Get this Report Now by email! BAY86-5016 87 Male contraception 88 Transdermal progestin plus testosterone 88 Cancer 88 Nanoemulsion-based delivery of caffeine for skin cancer 88 Transcutaneous electroporation for anticancer drugs 88 Transdermal drug delivery for prostate cancer 89 Transdermal nitroglycerine for prostate cancer 89 Transdermal estradiol gel for prostate cancer 89 Transdermal drug delivery for breast cancer 90 Afimoxifene topical gel for breast cancer 90 Pain 90 Relief of pain associated with minor medical procedures 90 Transdermal Lidoderm' for postherpectic neuralgia 90 Nonsteroidal antiinflammatory drugs 91 Topical NSAIDs 91 Transdermal ketoprofen 92 Topical opioids 93 Cancer pain 93 Transdermal fentanyl 93 Transdermal nitroglycerine as an adjuvant to opioids 94 Transdermal buprenorphine 95 Chronic pain of non-malignant origin 95 Transdermal local anesthetics 95 Postoperative pain 96 Transdermal fentanyl for the management of postoperative pain 96 Fibromyalgia 96 Nausea and vomiting 96 Motion sickness 96 Postoperative vomiting 97 Chemotherapy-induced nausea and vomiting 97 Antiaging strategies 97 Smoking cessation 98 Transdermal nicotine replacement 98 Other methods of nicotine replacement 99 Other treatments for smoking cessation 99 Miscellaneous uses of transdermal drug delivery 99 Chronic fatigue syndrome 99 Topical androgenic steroid therapy 100 Overactive bladder and urinary incontinence 100 Transdermal oxybutynin 100 Viral infections 100 Transdermal nanoparticles for immune enhancement in HIV 101 Transdermal gene therapy 101 Transdermal delivery of plasmid DNA by electroporation 102 Transdermal antisense therapy 102 Transdermal vaccination 103 The skin as an immune organ 103
Transdermal Drug Delivery - Technologies, Markets, and Companies (From Issuu)
Page 5/9
ReportLinker
Find Industry reports, Company profiles and Market Statistics
>> Get this Report Now by email! Technologies for transdermal vaccination 103 Dermal microinjection technology for delivery of vaccines 103 Electroporation for administering DNA vaccines 103 Intradermal delivery of cancer vaccines by adenoviral vectors 104 Needle free delivery of vaccines 104 Transcutaneous immunization 105 Applications of transdermal vaccination 105 HIV/AIDS vaccination by topical application 105 Transdermal DNA influenza vaccine 106 Transdermal A' vaccination for Alzheimer's disease 106 Transdermal vaccination for traveller's diarrhoea 106 Transdermal neutraceuticals 107 Complications of transdermal therapy 107 Adverse effects of drugs 107 Overdose effect 108 Skin complications 108 4. Markets for Transdermal Drug Delivery 109 Introduction 109 Global markets for drug delivery 109 Geographical distribution of transdermal drug delivery markets 110 Emerging transdermal drug delivery markets in Asia 110 Transdermal technology markets in therapeutic areas 110 Angina pectoris 111 Attention deficit hyperactivity disorder 111 Erectile dysfunction 111 Hypertension 112 Pain therapeutics 112 Parkinson's disease 112 Smoking cessation 112 Transdermal hormone replacement therapy for menopause 112 Transdermal testosterone replacement therapy for hypogonadism in the male 113 Transdermal contraceptive market 113 Markets according to transdermal technologies 113 Marketing strategies for transdermal drug delivery 114 Marketing advantages of transdermal drug delivery 114 Unmet needs in transdermal drug delivery 115 Future prospects of transdermal drug delivery 116 Prospects of transdermal delivery for drugs coming off patents 116 Transdermal delivery of cosmetics 117 5. Companies involved in transdermal drug delivery 119 Profiles of companies 119 Collaborations 252 6. References 257 List of Tables Table 1 1: Historical landmarks in the development of transdermal drug delivery 13 Table 1 2: Transdermal vs oral and intravenous drug delivery 15 Table 2 1: Technologies for transdermal drug delivery 19
Transdermal Drug Delivery - Technologies, Markets, and Companies (From Issuu)
Page 6/9
ReportLinker
Find Industry reports, Company profiles and Market Statistics
>> Get this Report Now by email! Table 2 2: Chemical enhancers of skin penetration 24 Table 2 3: Drug-in-adhesive versus reservoir type of transdermal patch 29 Table 2 4: Companies developing transdermal patches for drug delivery 30 Table 2 5: Companies with technologies for drug delivery by iontophoresis 38 Table 2 6: Companies involved in electroporation-based drug delivery 41 Table 2 7: Companies developing microneedles for transdermal drug delivery 49 Table 2 8: Comparison of transdermal drug delivery systems 55 Table 3 1: Approved transdermal products 61 Table 3 2: Transdermal drugs in clinical trials or approval process 63 Table 4 1: Worldwide drug delivery market growth 2010 to 2020 109 Table 4 2: Transdermal drug delivery markets for geographical regions 2010 to 2020 110 Table 4 3: Potential therapeutic markets for transdermal products 2010-2020 111 Table 4 4: Markets according to transdermal technologies 113 Table 4 5: Marketing strategies based on transdermal drug delivery technologies 114 Table 5 1: Collaborations in transdermal drug delivery 252 List of Figures Figure 1 1: Basic structure of the skin 14 Figure 1 2: Events governing transcutaneous drug absorption 17 Figure 2 1: Basic structure and function of transdermal drug delivery systems 29 Figure 2 2: A schematic view of electroporation 33 Figure 2 3: Depiction of breakdown of the stratum corneum during electroporation 35 Figure 2 4: A schematic drawing of Iontophoresis 36 Figure 2 5: SonoPrep ultrasonic skin permeation 43 Figure 2 6: A schematic drawing of the microneedle patch 47 Figure 3 1: Oral versus transdermal administration of a drug in Parkinson's disease 71 Figure 4 1: Unmet needs in transdermal drug delivery 116
Transdermal Drug Delivery - Technologies, Markets, and Companies (From Issuu)
Page 7/9
Find Industry reports, Company profiles and Market Statistics
ReportLinker
>> Get this Report Now by email! Fax Order Form To place an order via fax simply print this form, fill in the information below and fax the completed form to: ƒ ƒ
Europe, Middle East and Africa : + 33 4 37 37 15 56 Asia, Oceania and America : + 1 (805) 617 17 93
If you have any questions please visit http://www.reportlinker.com/notify/contact
Order Information Please verify that the product information is correct and select the format(s) you require. Transdermal Drug Delivery - Technologies, Markets, and Companies
Product Formats Please select the product formats and the quantity you require.
Digital Copy--USD 3 000.00
Quantity: _____
Contact Information Please enter all the information below in BLOCK CAPITALS
Title:
Mr
Mrs
Dr
Miss
Ms
Prof
First Name:
_____________________________ Last Name: __________________________________
Email Address:
__________________________________________________________________________
Job Title:
__________________________________________________________________________
Organization:
__________________________________________________________________________
Address:
__________________________________________________________________________
City:
__________________________________________________________________________
Postal / Zip Code:
__________________________________________________________________________
Country:
__________________________________________________________________________
Phone Number:
__________________________________________________________________________
Fax Number:
__________________________________________________________________________
Transdermal Drug Delivery - Technologies, Markets, and Companies (From Issuu)
Page 8/9
Find Industry reports, Company profiles and Market Statistics
ReportLinker
>> Get this Report Now by email! Payment Information Please indicate the payment method, you would like to use by selecting the appropriate box.
Payment by credit card
Card Number: ______________________________________________
Expiry Date
__________ / _________
CVV Number _____________________
Card Type (ex: Visa, Amex…) _________________________________
Payment by wire transfer
Crédit Mutuel RIB : 10278 07314 00020257701 89 BIC : CMCIFR2A IBAN : FR76 1027 8073 1400 0202 5770 189
Payment by check
UBIQUICK SAS 16 rue Grenette – 69002 LYON, FRANCE
Customer signature:
Please note that by ordering from Reportlinker you are agreeing to our Terms and Conditions at http://www.reportlinker.com/index/terms
Please fax this form to: Europe, Middle East and Africa : + 33 4 37 37 15 56
Asia, Oceania and America : + 1 (805) 617 17 93
Transdermal Drug Delivery - Technologies, Markets, and Companies (From Issuu)
Page 9/9