Neurosurgery Brain & Spinal Column - April 2021 - Vol 2 Iss 01 by Rutgers_Neurosurgery

NEUROSURGERY RUTGERS, NEW JERSEY MEDICAL SCHOOL & ROBERT WOOD JOHNSON MEDICAL SCHOOL | RWJBARNABAS HEALTH

BRAIN & SPINAL COLUMN VOLUME 2

ISSUE 01

Navigating Through a Global Pandemic

Faculty News

Chairman's Message

Residency

Overall Statistics

Research & Innovation

Past & Upcoming Events

Lyceum Symposium

2020 Year in Review

Highlighted Publications & Presentations

Systemwide Operations

APRIL 2021

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This quarterly newsletter of the Department of Neurosurgery at Rutgers, New Jersey Medical School & Robert Wood Johnson Medical School is designed to introduce physicians, researchers, prospective residents/fellows, medical students, and patients to our department and to provide topical discussions of current techniques and outcomes of neurosurgery.

Chairman's Message Dear Colleagues, As we recently celebrated Women’s History Month, I would like to acknowledge the important role women play in the Neurosurgery Department and throughout the system, by taking on leadership opportunities at clinical and administrative levels. We salute them for their service, dedication and sacrifices. It appears that the second COVID wave is decreasing and the operative numbers seem to be rebounding in a healthy and robust fashion. To kick off our Visiting Professor series in 2021, the Department of Pediatrics, in conjunction with the Department of Neurosurgery, welcomed Dr. Frederick A. Boop, in January. Dr. Boop gave a presentation on “Pediatric Brain Tumors: Past, Present and Future.” In February, the department welcomed Dr. Robert Dempsey as Visiting Professor, where he spoke on “Cerebrovascular Surgery: Passion, Inspiration, and Science Define our Future.” In March, the talented endovascular neurosurgeon from Barrow Neurological Institute, Dr. Felipe C. Albuquerque, gave a presentation on “Endovascular Management of Wide-Necked Cerebral Aneurysms.” In April, we’re thrilled to announce that Dr. Volker K.H. Sonntag, will be presenting his talk on “The Journey of Spinal Neurosurgery in the United States.”

We are pleased to update you regarding the Global Neurosurgery Lyceum Series, as our Stroke & Neurovascular Symposium will be held virtually on Thursday, May 20th and our Global Neurosurgical Update and Educational Summit will also be held virtually on Friday, July 9th and Saturday, July 10th 2021. On the research front, I’m delighted to inform you that Dr. Mi-Hyeon Jang, will be joining Dr. Detlev Boison to aid in the research developments within the department. Professor Jang previously served in the Department of Neurosurgery at Mayo Clinic, and has two R01s and has published over 100 articles. This brings the total R01s in the Department of Neurosurgery to five, and puts us in a highly competitive spot nationally. On the educational front, I’m delighted to announce that Ryan Radwanski from Weill Cornell Medical School and Nemanja Novakovic from the University of Michigan have matched in our program. This was a very successful match for the department, and I would like each of you to welcome them. Unfortunately, as of now there will not be a graduation party for our residents, but we will have a virtual graduation with Dr. Mitchel S. Berger from UCSF, speaking to us on brain tumors. Kindly stay safe.

Anil Nanda, MD, MPH, FACS Peter W. Carmel M.D. Chair of Neurological Surgery Professor and Chair, Department of Neurosurgery Senior Vice President for Neurosurgical Services, RWJBarnabas Health Chair and Chief of Service, Department of Neurosurgery, University Hospital

Faculty Chairman and Professor Anil Nanda, M.D., MPH, FACS

Research Assistant Professor Vineet Chitravanshi, Ph.D.

Professor James Liu, M.D. Shabbar Danish, M.D. Kiwon Lee, M.D.*

St. Barnabas Medical Center Faculty Otakar Hubschmann, M.D. Joseph Koziol, M.D.

Associate Professors Ira Goldstein, M.D. Gaurav Gupta, M.D. David Kung, M.D. Sudipta Roychowdhury, M.D.* Jasdeep S. Hundal, Psy.D., ABPP

Chief Residents Omar Iqbal, M.D. Nitesh Patel, M.D. Asif Shafiq, D.O.

Research Professors Detlev Boison, Ph.D. Stella Elkabes, Ph.D., MS Dongsheng Cai, M.D., Ph.D.

Residents Neil Majmundar, M.D. Matthew Cummock, M.D. Amanda Carpenter, M.D. Blake Taylor, M.D. Kevin Zhao, D.O. Grant Arzumanov, D.O. Manan Shah, M.D. Christopher Talbot, M.D. Purvee Patel, M.D. Timothy Wong, M.D. Raja Jani, D.O. Sean Munier, M.D. Ali Tayebi-Meybodi, M.D. Elizabeth Ginalis, M.D. Travis Quinoa, M.D. Evgenii Belykh, M.D.

Research Associate Professor Randall D. McKinnon, Ph.D. Yong Kim, Ph.D. Hai Sun, MD, Ph.D.

Fellows Taha Nasir, M.D. Muhammad Zeeshan Memon, M.D. Joseph Quillin, M.D.

Assistant Professors Priyank Khandelwal, M.D. John L. Gillick, M.D. Pankaj K. Agarwalla, M.D. Amit Singla, M.D. Stephen Johnson, M.D. Margaret Pain, M.D. Ashish Sonig, M.D. Alice Edwards, MSPA-C

Clinical Instructors Eric Hargreaves, Ph.D.

833-NJ-NEURO www.rwjbh.org/neurosurgery http://njneuro.rutgers.edu/

Like us on Facebook facebook.com/RutgersNeurosurgery

Connect with us on LinkedIn linkedin.com/in/rutgersneurosurgery/

*Joint Faculty

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Neurosurgery: Navigating Through a Global Pandemic The COVID-19 pandemic has presented a variety of challenges to health care systems and drastically impacted the delivery of medical care worldwide. Similar to most specialties, neurosurgery warrants special considerations since many of the necessary procedures are time-sensitive. Any delays in necessary intervention may cause permanent neurological damage, which may affect a patient’s quality of life or even lead to death. Thankfully, we can deliver neurosurgical care through telemedicine, to especially protect the already at-risk population. With the support of our staff, we were able to temporarily move our onsite-patient clinics to 90% telemedicine to decrease possible exposure to COVID-19. In addition, we have been able to resume our Global Grand Rounds lectures virtually since June and host a major event, which was the Global Neurosurgery: Ask Not for Whom the Bell Tolls virtual symposium. In April we received an abundant donation of masks. This initiative was organized by the mother of one of our residents, Dr. Blake Taylor. Mrs. Nadine Taylor-Barnes gathered a donation from iHealth Labs, Inc. of 200 N95 masks, while Blake’s sister, Madison, who is a neuroscientist at Neuralink (founded by Elon Musk), appealed through her company to facilitate the donation of 50 ventilators from Tesla, Inc. to the Department of Neurosurgery at Rutgers, New Jersey Medical School. Mrs. Nadine Taylor-Barnes & Madison Taylor

Project 100 When the COVID-19 pandemic hit and the clinics closed down to permit only essential care to be done, we needed a new challenge to maintain academic standards for the education of our residents. Out of this need, Project 100 was born, a collection of scholarly activities to be done remotely by engaging residents, medical students, and faculty in publication projects. Project 100 turned into a successful endeavor, resulting in 245 projects and the immersion of residents in research projects, which could be done remotely and safely. (Below are just a few Projects) Residents

Faculty

Blake Taylor, MD 1. Nation 1. Nationwide Readmissions Database (NRD) Outcomes Project (2019-) 2. EVD Complications Outcomes Project (2019-)

Priyank Khandelwal, MD 1. Feasibility of infinity catheter (.88 and .91 Large bore catheters) for Neurointerventional procedures via TRA approach: Prospective study. 2. Retinal Hemorrhages and flow change in Ophthalmic post flow diverter placement across the paraophthalmic segment. : Prospective study.

3. Postoperative Activity Tracking for Functional Recover (2019-) Neil Majmundar, MD 1. Arteria Lusoria- Endovascular techniques 2. Surpass stent case series 3. NBCA Historical Paper 4. COVID Stroke 5. Raccess occluded radial artery

3. Cost effectiveness of Trans radial approach for diagnostic cerebral angiogram and concept of radial lounge ; A quality improvement project. Vineet Chitravanshi, PhD 1.Functional alterations in the brain cardiovascular regulatory areas after Traumatic Brain Injury. 2. Neural pathways mediating cardiovascular changes after Traumatic Brain Injury. 3. Central effects of recombinant Covid-19 proteins (N and S proteins) microinjected into the cardiovascular and respiratory area of spontaneously hypertensive rats (SHR), Wistar Kyoto (WKY) rats and Wistar rat.

6. Telemedicine in COID Era

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2 0 2 0

OVERALL STATISTICS

8 35

Faculty CoInvestigators or PI’s on Extramural Grants

Published Books/Book Chapters

Articles in Peer-Reviewed Journals

245

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Combined total of Project 100 Research Assignments by Faculty and Residents

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The Department of Neurosurgery continues to enjoy robust growth. Over the course of the last two years, we have recruited 13 additional neurosurgeons, including endovascular and basic scientists.

350 19 3

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Current faculty members

residency applications for 2020 current residents

current fellows

Departmental Expansion

Clinical

Faculty News

Drs. David Kung and Ashish Sonig recently joined our clinical faculty. David K. Kung, M.D. will be joining our department as an Associate Professor of Neurosurgery and serve as Co-Director of Endovascular Neurosurgery throughout the system. He will be based out of Saint Barnabas Medical Center. Dr. Kung previously served as Assistant Professor and Director of the Penn Comprehensive Stroke Center at the University of Pennsylvania. He earned his medical degree from Albert Einstein College of Medicine in 2006, completed his neurosurgery residency at the University of Iowa, and completed a fellowship in Neurovascular Surgery and Endovascular Neurosurgery at Jefferson Hospital. Ashish Sonig, M.D., an Endovascular Neurosurgeon, who previously served as Chief Resident in the Department of Neurosurgery at the University of Buffalo, recently joined us as an Assistant Professor of Neurosurgery, and he will be based out of Newark Beth Israel and University Hospital. He received his medical training at the National Institute of Mental Health and Neurosciences in Bangalore, India, and completed his neurosurgical residency training and Endovascular fellowship from the University at Buffalo. Additionally, completed his Skull Base fellowship from Louisiana State University Health Sciences Center. Last August, we welcomed Dr. Margaret E. Pain, M.D. as an Assistant Professor of Neurosurgery, to our team at Robert Wood Johnson Medical School. Dr. Pain is a Pediatric Neurosurgeon, who specializes in treating pediatric patients with neurosurgical conditions. She recently completed her Chief Residency year in 2019 at Mount Sinai Hospital, in New York, NY. Dr. Pain graduated from Carleton College cum laude in 2006 with a chemistry degree and completed a research fellowship in molecular physiology at the National Institutes of Health in 2008. She obtained her medical doctorate from the University of Minnesota Medical School in 2012.

David K. Kung, M.D.

Ashish Sonig, M.D.

Margaret E. Pain, M.D.

Endovascular Neurosurgery

Pediatric Neurosurgery

Research As part of the expansion of our research program, we are pleased to welcome two new faculty members to our department. Yong Kim, Ph.D. joined us in November on our campus in Piscataway as Associate Professor on the tenure track. He comes from Nobel laureate Paul Greengard’s Laboratory of Molecular and Cellular Neuroscience at The Rockefeller University in New York City, NY. His research focuses on molecular and cellular processes employed by the brain to correct challenges to homeostasis as triggered for example by traumatic brain injury (TBI). This research is relevant to develop novel therapeutic strategies to stimulate repair and to ameliorate risk factors for neurodegenerative and cognitive complications after TBI. Mi-Hyeon Jang, Ph.D. will be joining us on August 1st 2021. Professor Jang previously served in the Department of Neurosurgery at Mayo Clinic. Her research will focus on Adult Neurogenesis, Regenerative Medicine, and Chemobrain. She has two R01s and has published over 100 articles.

Yong Kim, Ph.D. 6

Mi-Hyeon Jang, Ph.D. VOLUME 2

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Continuing Medical Education Series The Department of Neurosurgery hosts educationally rich conferences for faculty and residents, typically on Wednesdays. These conferences are organized such that it allows for an open discussion of cases, resident presentations, guest speakers, and faculty participation that includes questioning and unstructured dialogue. Due to COVID-19 restrictions, our department converted the weekly Brain & Spinal Tumor board into a virtual meeting and created a virtual grand rounds system to overcome these challenges. Nonetheless, we had the privilege of welcoming eight grand rounds lecturers this year. Each lecturer is a distinguished national or international academician, whose lectures have covered areas in Spine, Functional, Cerebrovascular, Tumor/Skull Base, and Pediatric Neurosurgery.

Karin Muraszko, M.D.

M. Sean Grady, MD

"The Life of An Academic Neurosurgeon" January 22nd, 2020

“A Unifying Hypothesis behind the Short and Long Term Consequences of Concussion" February 5th, 2020

Steven N. Kalkanis, M.D.

Lawrence G. Lenke, M.D. "A New Classification of Adult Idiopathic Scoliosis: Evaluation and Treatment Guidelines" June 10th, 2020

Carl B. Heilman, M.D.

Robert F. Spetzler, M.D. "My Journey Through Neurosurgery" June 25th, 2020

Michael Wang, M.D.

"Innovation in Brain Tumor Surgery in the Precision Medicine Era" August 26th, 2020

"Evolution of Preferred Skull Base Approaches" September 30th, 2020

"Ultra-MIS Spinal Surgery" October 21st, 2020

Frederick A. Boop, M.D.

Robert J. Dempsey, M.D.

Felipe C. Albuquerque, M.D.

"Predicting Neurological Recovery after Traumatic Spinal Cord Injury" January 21st, 2021

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"Cerebrovascular Surgery: Passion, Inspiration, and Science Define our Future" February 24th, 2021

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"Endovascular Management of Wide-Necked Cerebral Aneurysms" March 31st, 2021

Randall M. Chesnut, M.D.

"Evidence-Based Medicine versus Medicine-Based Evidence: Bridging the Gap Between Literature and Practice" August 12th, 2020

Steven Kirshblum, M.D. "Predicting Neurological Recovery after Traumatic Spinal Cord Injury" December 2nd, 2020

Volker K. H. Sonntag, M.D. "The Journey of Spinal Neurosurgery in the United States" April 21st, 2021

Successful Trials The Rutgers Brain and Spine Tumor Program at Rutgers, New Jersey Medical School had a successful year with our brain tumor trials. We opened and enrolled in an exciting BRAF/MEK inhibitor trial for papillary craniopharyngioma. We also opened trials for radiation therapy in grade 2 meningioma and a trial for brain metastases. We are currently investigating additional trial options for glioblastoma including industry-led trials. The comprehensive tumor board led by Pankaj Agarwalla, M.D., Assistant Professor of Neurosurgery, and Anupama Chundury, M.D., Assistant Professor of Radiation Oncology, has led to improved communication and patient care across our multiple sites, particularly with the increased use of teleconferencing platforms. In the coming year, we plan to roll out a neuro-oncology journal club for trainees and develop our own investigator-initiated trials.

Vesalius Laboratory The Vesalius Neurosurgical Anatomy Laboratory, also known as the "Skull Base Lab", aims to create an environment that nurtures, cherishes, enhances, and executes novel anatomical research ideas to push the neurosurgical anatomical research field by publishing top-notch papers in world-class neurosurgery journals. This objective will provide the research fellows with the opportunity to learn anatomy and improve their manual dexterity using neurosurgical instruments while working in a simulated surgical field. The Vesalius Laboratory is Co-Directed by Ali Tayebi Meybodi, M.D. (PGY 2) and Pankaj Agarwalla, M.D., Assistant Professor of Neurosurgery. They plan to utilize the microanatomical and surgical simulation laboratory and equip it with operating microscopes, endoscopes and towers, silicone-injected cadaver heads, and surgical instruments.

The Vesalius Neurosurgical Anatomy Laboratory, neurosurgical trainees, including residents and fellows will: Enhance their understanding of skull base and neurosurgical anatomy. Rehearse manual dexterity and microsurgical/endoscopic surgical skills. Conduct anatomical research projects.

Committee Anil Nanda, M.D., MPH, FACS Pankaj Agarwalla, M.D. James K. Liu, M.D. Vineet Chitravanshi, Ph.D. Bharath Raju, MBBS, MCh Ali Tayebi Meybodi, M.D. (PGY 2) Evgenii Belykh, M.D. (PGY 1) Mohsen Ahmed (Medical Student) Portrait of Vesalius featured in De Humani Corporis Fabrica

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Residency & Fellowship Program

Fellows In 2020, we welcomed four new residents into our department.

Elizabeth Ginalis, M.D. PGY 1

Travis Quinoa, M.D. PGY 1

Evgenii Belykh, M.D. PGY 1

Manan Shah, M.D. PGY 5

In 2021, the following candidates matched into our program.

Nemanja Novakovic, M.D.

Ryan Radwanski, M.D.

Fellows In 2020 we welcomed two neuro-endovascular fellows, Muhammad Zeeshan Memon, M.D. and Taha Nisar M.D., training under Dr. Priyank Khandelwal. We also welcomed a skull base fellow, Joseph Quillin, training under Dr. James K. Liu.

Muhammad Zeeshan Memon, M.D. Neuro-Endovascular Fellow

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Taha Nisar M.D. Neuro-Endovascular Fellow

Joseph Quillin, M.D. Skull Base Fellow

Recognitions Congratulations to one of our Chief Residents, Nitesh Patel, M.D. (PGY 7) for being selected to receive the GME Resident/Fellow Recognition Award for enhancing resident wellbeing at the institution. We are pleased to honor Nitesh who is determined to improve resident wellness with enthusiasm, passion, and proficiency. He has demonstrated a firm commitment to resident wellness and was praised for his leadership roles and initiatives to contribute to this effort. During his time in the department, Nitesh has published a large number of articles focused on Laser-Induced Thermal Therapy (LITT) and brain tumors. He will be heading to Miami after residency to complete a CAST certified surgical neuro-oncology fellowship with Dr. Ricardo Komotar. We believe that he will continue to make major clinical and scientific contributions to the field of neurosurgery. Nitesh Patel, M.D. PGY 7

Congratulations to one of our PGY 1 Residents, Elizabeth Ginalis, M.D. for receiving the Silver Medal Award for SRS Research from the AANS/CNS Tumor Section Satellite Symposia Awards for her research on "Two-staged Stereotactic Radiosurgery for the Treatment of Large Brain Metastases" in June 2020. Ginalis EE, Cui T, Weiner J, Nie K, Danish SF. Two-staged Stereotactic Radiosurgery for the Treatment of Large Brain Metastases: Single Institution Experience and Review of Literature. Journal of Radiosurgery and SBRT. 2020 Aug; 7(2):105-114. Elizabeth Ginalis, M.D. (PGY1)

A multicenter study titled, “Magnetic resonance-guided laser interstitial thermal therapy for posterior fossa neoplasms”, led by Shabbar Danish, M.D., Professor of Neurosurgery and Director of Functional Neurosurgery, along with resident Grant Arzumanov, D.O. and medical student Omar Ashraf, B.A., was recently published in the Journal of Neuro-Oncolog and is the largest case series of LITT in the posterior fossa. Laser interstitial thermal therapy (LITT) has proven to be a key innovation in neurosurgical oncology. The study evaluated 58 patients who underwent LITT between Rutgers University, University of Miami, Emory University, and Henry Ford Omar Ashraf

Grant Arzumanov, D.0. PGY5

Hospital. The authors found that local control rates for intracranial

neoplasms including both primary and secondary tumors were over 84% with a median follow up of 9.5 months. These patients had a shorter hospital stay, on average of only one day, compared to open procedures with complications primarily related to the eloquence of brain tissue involved. This publication won an award at the CNS tumor section and has been featured in the Journal of Neurooncology and Congress of Neurological Surgery Tumor Talks.

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Neurosurgery Welcomes

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Scholarly Activities The 2nd Annual Neurosurgery Research Symposium hosted by the Department of Neurosurgery at Robert Wood Johnson Medical School and New Jersey Medical School, as well as RWJBarnabas Health, took place on March 11th, 2021. The symposium featured cutting edge neurosurgery research from our department ranging from spinal cord, brain injuries and epilepsy to age related neurodegenerative disorders and brain cancers.

Upcoming event

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Project Neuron is a combined effort by two of our residents, Kevin Zhao, D.O. (PGY 5) and Grant Arzumanov, D.O. (PGY 5). Since the start of Project 100, the number of research projects in our department has skyrocketed. Multiple medical students have expressed their interest in getting involved with projects. Project Neuron (projectneuron.com) is a platform intended to connect Kevin-Zhao, D.0. PGY5

medical students with opportunities in neuroscience to help them

Grant Arzumanov, D.0. PGY5

pursue a career in Neurology or Neurosurgery. It is a platform that will provide medical students with opportunities to collaborate with faculty and residents on research projects.

Committee

Rutgers Neurosurgery

H ealth O utcomes P olicy Anil Nanda, M.D., MPH Professor & Chairman, Department of Neurosurgery

E conomics

Pankaj Agarwalla, M.D.

Assistant Professor of Neurosurgery (Skull Base and Cerebrovascular Surgery)

Detlev Boison, Ph.D

Professor of Neurosurgery and Vice Chair of Research

Gaurav Gupta, M.D.

Associate Professor of Neurosurgery & Director of Cerebrovascular & Endovascular Neurosurgery

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The department is determined to improve outcomes and reduce the economic burden of patient care even after the global pandemic, which is why the H.O.P.E. Center was created. The H.O.P.E. Center is focused on research that promotes a better understanding of health outcomes, policy, and economic factors in the area of neurosurgery and beyond. Headed by Patrick Hilden, Biostatistician, and Dr. Anil Nanda, Professor & Chairman of the Department of Neurosurgery, the central goal is to improve outcomes and reduce the economic burden of patient care. By combining experts in clinical neurosurgery, basic science, data analytics, patient safety, and health economics, we perform multidisciplinary research and policy proposals to benefit our community in New Jersey, and worldwide.

Hai Sun, M.D., Ph.D.

Associate Professor of Neurosurgery & Assistant Director of Research

Laura T. Pizzi, PharmD, MPH Director, Health Outcomes, Policy, and Economics (HOPE) Program and ProfessorRutgers University

John Gillick, M.D.

Assistant Professor of Neurosurgery (Spine)

Jason Roy, Ph.D.

Chair & ProfessorDepartment of Biostatistics and Epidemiology

Global Neurosurgery: Ask Not for Whom the Bell Tolls September 10-12, 2020

Global Neurosurgery: Ask Not for Whom the Bell Tolls The high point of our academic endeavors this past year, was when The Department of Neurosurgery at the Robert Wood Johnson Medical School and the New Jersey Medical School, in a partnership with RWJBarnabas Health, hosted the WFNS: Global Neurosurgery Ask Not for Whom the Bell Tolls global neurosurgery symposium. The seminar was comprised to bring together preeminent neurosurgeons from around the world to share their knowledge through education and innovation. Mindful of the ongoing COVID-19 pandemic, it was decided that the meeting would be held as an all-virtual conference, taking place over the course of three days, from September 10-12, 2020. We felt incredibly fortunate to be able to amass some 160 of the most prominent neurosurgeons from the top institutions around the world, who shared with us with their expertise and insight into neurosurgical matters revolving global concerns. The high point of our seminar was most certainly the commencement of the 1st Annual Peter W. Carmel Oration, in honor of Peter W. Carmel, and his universal contributions to neurosurgery. We graciously welcomed the world’s foremost expert on social determinants, Professor Sir Michael Marmot, as the keynote speaker for this occasion. Professor Marmot spoke on social justice and health equities surrounding the current COVID-19 pandemic, and set an inspiring tone which would reverberate and be replicated through the duration of the event. A few of the more noteworthy presentations came to us from Robert Spetzler, who spoke about passing on experiences in neurosurgery; Franco Servadei asked what the neurosurgical community learned from the COVID pandemia; Majid Samii touched on management of facial nerve in neurosurgery; Karin Muraszko addressed leadership development for neurosurgery residents; James Rutka highlighted Canada’s, Ukraine pediatric specialty fellowship program; Nelson Oyesiku questioned what comes after The Lancet Report; and Edward Benzel covered the topical subject of COVID-19 and a team approach to stressors. A portion of our program was also dedicated to residents and medical students. We received a generous grant from the David and Lya Neumann Foundation, facilitated by Drs. Otakar Hubschmann and Joseph Koziol at Saint Barnabas Medical Center, which allowed us this opportunity. There were nearly 100 abstracts submitted, with 36 chosen for presentation during our live event, and five winners selected. The stunning success of this program, couldn’t have been possible without the tireless work of everyone involved in our scientific programming committee, the entire faculty and staff. We’re working towards an ambitious set of CME events for 2021, covering such topics as Spine, Trauma, Brain, Stroke and Global Medical Student & Resident Education. Our mission is to bring the Rutgers Neurosurgery Department to the forefront of academic advancements through a continued series of globally themed neurosurgical programs.

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Global Neurosurgery: Ask Not for Whom the Bell Tolls September 10-12, 2020

HIGHLIGHTS 1,030+ Total Registrants 160 Total Speakers across 34 countries over three days 36 Live Abstract Presentations 53 e-posters 55 Moderators Broadcast and translated live to over 400+ people in China A combined total of 11,300 Facebook live views for the event, reaching almost 41,000 people across 44 countries around the globe.

We received a generous grant from the David and Lya Neumann Foundation, facilitated by Drs. Otakar Hubschmann and Joseph Koziol at Saint Barnabas Medical Center, which allowed us the opportunity to dedicate a portion of our program to residents and medical students. Nearly 100 submitted Abstracts

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36 Live Abstract Presentations

Highlights "The WFNS Global Neurosurgery Program was by far the best neurosurgery meeting in 2020. The scientific content was outstanding and the ‘who’s who of Neurosurgery’ was there thanks to Prof. Anil Nanda. Especially interesting was not only the eminent faculty but also the active participation by many young neurosurgeons. The icing on the cake was the thought-provoking Peter Carmel Oration by Sir Michael Marmot. It was an honor for me to have contributed to the program.” - Basant Misra, First-Vice President, World Federation of Neurological Surgeons

“I hope very much this type of scientific program will go on in order to keep on education and development of sciences in neurosurgery worldwide.” - Madjid Samii, President of the International Neuroscience Institute

“By going online and being free, 'Ask not for whom the bell tolls' became accessible to many young Africans interested in neurosurgery. This spanned medical students, young doctors looking for residency opportunities, residents, and consultants. It was an opportunity to listen to international experts and much was learned. Many were encouraged and are indeed working on projects to present in future meetings. It was simply about giving visibility and a voice to a group who have previously not been included in quite the same way.” - Beverly Jebet Cheserem, Assistant Professor of Neurosurgery, Aga Khan University Hospital, Nairobi, Kenya

“Congratulations to Anil and team - you have ushered in a new era for meetings in general and Global Neurosurgery in particular. Bravo... and thank you!” - Gail Rosseau, Clinical Professor of Neurosurgery, George Washington University

“The WFNS Global Neurosurgery program under Dr. Anil Nanda was a resounding success! In these uncertain times, Dr. Nanda’s program was exceptional in its content and the ability to provide community.” - Regis W. Haid, Jr., M.D, Atlanta Brain and Spine Care

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2021 Global Neurosurgery Lyceum Series

Stroke & Neurovascular Symposium Register Now Scan QR Code Below

Symposium Dates Stroke & Neurovascular Symposium: Thursday, May 20th 2021 Scan QR Code Register NOW!

Global Neurosurgical Update & Educational Summit: Friday, July 9th & Saturday, July 10th, 2021 Spine Symposium: Friday, September 10th 2021 Brain Tumor Symposium: Thursday, November 11th 2021

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Highlighted Publications & Presentations in 2020 Anil Nanda, M.D., MPH, FACS 1. Raju B, Jumah F, Ashraf O, Narayan V, Gupta G, Sun H, Hilden P, Nanda A. Big Data, Machine Learning, and Artificial Intelligence: A field guide for Neurosurgeons. JNS. Online Publication Date 2 Oct 2020. https://doi.org/10.3171/2020.5.JNS201288 2. Hansen RB, Silva N, Cuevas R, Richardson A, Mammis A, Nanda A. "Fellowship, gender, and scholarly productivity: Trends among academic neurosurgeons in the United States." Journal of Neurosurgery. Vol 132. Issue 4. Online Publication Date: 28 Aug 2020. https://doi.org/10.3171/2020.5.JNS20577 3. Jumah F, Rallo MS, Quinoa T, Raju B, Narayan V, Gupta G, Nanda A. Incidental Brain Tumors in the Pediatric Population: A Systematic Review and Reappraisal of Literature. World Neurosurgery. Volume 139, July 2020, Pages 121-131 https://doi.org/10.1016/j.wneu.2020.02.178 4. Jumah F, Narayan V, Samara A, Quinoa T, Dossani RH, Gupta G, Nanda A. Efficacy and Safety of Gamma Knife Radiosurgery for Posterior Cranial Fossa Meningioma: A Systematic Review. Neurosurgical Review, July 2019. 5. Rallo MS, Ashraf O, Jumah F, Gupta G, Nanda A. An analysis of cross-continental scholarship requirements during neurosurgical training and national research productivity. 2020 March 1. Neurosurg Focus. 2020 Mar 1;48(3):E20. doi: 10.3171/2019.12.FOCUS19856 Presentations 1. Session Panelist: The Twelfth WFNS Rabat Reference Center Course for African Neurosurgeons. Virtual Meeting. November 18th, 2020. 2. Speaker: “Microsurgery, Metacognition, and Mentorship.” Asian Congress of Neurological Surgeons. Zoom Meeting. November 7th, 2020. 3. Moderator and Speaker: “Skull Base Surgery – Resisting the Siren’s Song.” Virtual Conference - RWJBH and Rutgers Biomedical Health & Sciences, 2nd Annual Stroke and Neurocritical Care Symposium (Neuro-Emergencies during the pandemic). November 6th, 2020. 4. Speaker: “Global Neurosurgery: Ask Not for Whom the Bell Tolls.” Virtual Conference - 15th Asian-Oceanian International Congress on Skull Base Surgery. October 25th, 2020. 5. Speaker: “Skull Base Surgery – Rembrandt vs Picasso.” Virtual Conference - 32nd Annual Meeting of Japanese Society for Skull Base Surgery. October 24th 2020.

James K. Liu, M.D. 1. Majmundar N, Patel P, Dodson V, Bach I, Liu JK, Tomycz L, Khandelwal P. First Case Series of the Transradial Approach for Neurointerventional Procedures in Pediatric Patients. Journal of Neurosurgery: Pediatrics 31:1-5, 2020, PMID 32005020 2. Liu JK, Behmer Hansen RT, Couldwell WT. Letter to the Editor Regarding “Pituitary Apoplexy: Large Surgical Series with Grading System”. World Neurosurgery 135:405, PMID 32143261 3. Patel PD, Meybodi AT, Agarwalla P, Jyung RW, Liu JK. Rapid Recovery of Cranial Nerve Deficits After Anterior Petrosal (Kawase) Approach for Medically Refractory Petrous Apicitis. World Neurosurgery 140:122-127, 2020 [Epub 2020 May 17], PMID 32434021 4. Talmor G, Grube JG, Eloy JA, Liu JK, Hsueh WD. Nasoseptal Flap Necrosis After Endoscopic Skull Base Surgery in the Setting of COVID-19 Pandemic. World Neurosurgery 140:374-377, 2020 [Epub 2020 May 29], PMID 32479908 5. Patel SK, Markosian C, Choudhry OJ, Keller JT, Liu JK. The Historical Evolution of Microvascular Decompression for Trigeminal Neuralgia: From Dandy’s Discovery to Jannetta’s Legacy. Acta Neurochirurgica (Wien) 162(11):2773-2782, 2020 [Epub 2020 Jun 9], PMID 32519161 Presentations 1. Egyptian Society of Neurological Surgeons and Continental Association of African Neurosurgical Societies, Webinar #27, Skull Base Surgery Mastering the Temporal Bone: Transpetrosal Approaches to Skull Base and Vascular Lesions November 27, 2020 (invited lecture, international CME) 2. Neurosurgical Atlas: Virtual Operating Room Series Mastering the Temporal Bone: Transpetrosal Approaches to Skull Base and Vascular Lesions November 16, 2020 (invited lecture, international CME) 3. Masters with Turkish Rhoton Fellows Group, Skull Base Course Online Anterior Petrosal Approach: Case Presentation and Surgical Videos November 8, 2020 (invited lecture, international CME) 4. Curso 360 Degrees, Base de Craneo, Microcirugia Abierta Y Endoscopic, Parte 1 Stryker Mahwah Lab Combined Petrosal Approach: Live Cadaver Demonstration November 6, 2020 (invited lecture, international CME) 5. Curso 360 Degrees, Base de Craneo, Microcirugia Abierta Y Endoscopic, Parte 1 Stryker Mahwah Lab Anterior Petrosal Approach: Live Cadaver Demonstration November 6, 2020 (invited lecture, international CME)

VOLUME 2

ISSUE 01

APRIL 2021

Highlighted Publications & Presentations in 2020 Continued

Shabbar Danish, M.D. 1. S Baydin, A Gungor, V Holanda, N Tanriover, and S Danish. Microneuroanatomy of the Anterior Frontal Laser Trajectory to the Insula. World Neurosurgery. E1-e13. 2019 2. Ginalis E, Solli E, Patel N, and Danish S. Commentary: Laser Ablation of Abnormal Neurological Tissue using Robotic neuroblate System (LAANTERN): Procedural Safety and Hospitalization. Neurosurgery 2019. 3. Lacava S, Mehta M, Schiff D, Handoni A, Sachin J, Danish S, Haffty B, Chen S, Khan A. The Glutamate Release Inhibitor Riluzole Increases DNA Damage and Enhances Cytotoxicity in Human Glioma Cells. Oncotarget 2019 4. Bai Y, Cao H, Xiao Z, Zhang Y, Kowng T, Danish S, Weiner J, Wang , Yue N, and Nie K. Dosimetric comparisons of different hypofractionated stereotactic radiotherapy techniques in treating intracranial tumors >3cm in longest diameter. Journal of Neurosurgery. March 2019 5.

Wong S., Danish S, and Mani R. Comparison and Selection of Current Implantable Anti-Epileptic Devices. Neurotherapeutics. 2019

Detlev Boison, Ph.D. 1. Boison D, Rho MJ (2020) Epigenetics and epilepsy prevention: the therapeutic potential of adenosine and metabolic therapies. Neuropharmacology 167:107741. doi: 10.1016/j.neuropharm.2019.107741. PMID: 31419398152 2. He X, Chen F, Zhang Y, Gao Q, Guan Y, Wang J, Zhou J, Zhai F, Boison D, Luan G, Li T (2020) Upregulation of adenosine A2A receptor and downregulation of GLT1 is associated with neuronal cell death in Rasmussen's encephalitis. Brain Pathol. 30(2):246260. PMID: 31353670 3. Boison D & Yegutkin G (2019) Adenosine metabolism: Emerging concepts for cancer therapy. Cancer Cell 36: 582-596 PMID: 31821783 4. Binder DK, Boison D, Eid T, Frankel WN, Mingorance A, Smith BN, Dacks PA, Whittemore V, Poduri A; AES/NINDS Epilepsy Benchmarks Stewards (2020) Epilepsy Benchmarks Area II: Prevent Epilepsy and Its Progression. Epilepsy Currents 20(1_suppl):14S-22S 5. He X, Chen F, Zhang Y, Gao Q, Guan Y, Wang J, Zhou J, Zhai F, Boison D, Luan G, Li T (2020) Upregulation of adenosine A2A receptor and downregulation of GLT1 is associated with neuronal cell death in Rasmussen's encephalitis. Brain Pathol. 30(2):246-260. PMID: 31353670 Presentations 1. Child Health Institute of New Jersey, RWJMS, New Brunswick, NJ “Adenosine and epigenetics – a developmental hypothesis of schizophrenia” 2. Hibernation Symposium, University of Alaska, Fairbanks, AK (remote) “Adenosine: A key link between metabolism, signaling and gene expression” 3. Trinity College, Neuroscience Program, Hartford, CT (remote) Fall Lecture Series Speaker: “Translational adenosine research” 4. North American Epilepsy Congress (Toronto, remote) Session: Metabolism- and diet-based treatments for epilepsy: current evidence and controversies, Presentation title: “Anti-epileptogenesis: the role of metabolism and epigenetics”

Stella Elkabes, Ph.D. 1. Li L, Ni L, Heary RF, Elkabes S. (2020) Astroglial TLR9 antagonism promotes chemotaxis and alternative activation of macrophages via modulation of astrocyte-derived signals: implications for spinal cord injury. J Neuroinflammation. 17:73. 2. Li L, Acioglu C, Heary RF, Elkabes S (2020) Role of astroglial toll-like receptors (TLRs) in in central nervous system infections, injury and neurodegenerative disorders (2020) Brain Behav. Immun. S0889-1591(20)31896-1. Online ahead of print. 3. Li L*, Acioglu C*, Heary RF, Elkabes S(2020) Innate Immune responses of glia and inflammatory cells in spinal cord injury. In: Neuroscience of Spinal Cord Injury. Preedy VR Editor, Elsevier (in press)

Ira Goldstein, M.D. 1. Mau C, Goldstein I. External Ventricular Drain Migration Causing Parinaud's Syndrome: A Case Report. Cureus. 2020 Oct 16;12(10):e10981. doi: 10.7759/cureus.10981. PMID: 33209537

Gaurav Gupta, MD 1. G Gupta, D Eckstein, V Narayan, F Jumah, MD, Anthony A DePalma, MD, Stephen J Sozio, MBS, Nancy Prendergast, MD, Steven Schonfeld, MD, Irwin Keller, MD, Fawaz Al-Mufti, MD, Michael Nosko, MD, Anil Nanda, MD, Sudipta Roychowdhury, MD. Endovascular Management of Intracranial Vertebral Artery Dissection: Technical Nuances for the Preservation of Posterior Inferior Cerebellar Artery and Basilar Artery. 11 June 2020. Operative Neurosurgery. https://doi.org/10.1093/ons/opaa174

NEUROSURGERY

BRAIN & SPINAL COLUMN

Highlighted Publications & Presentations in 2020 Continued

Hai Sun, M.D., Ph.D. 1. Li Q, Zhang Y, Ge BY, Sun H., et al. GPR50 Distribution in the Mouse Cortex and Hippocampus [published online ahead of print, 2020 Jul 21]. Neurochem Res. 2020;10.1007/s11064-020-03089-w. doi:10.1007/s11064-020-03089-w 2. Kalakoti P, Edwards A, Ferrier C, Sun H., et al. Biomarkers of Seizure Activity in Patients With Intracranial Metastases and Gliomas: A Wide Range Study of Correlated Regions of Interest. Front Neurol. 2020;11:444. Published 2020 May 29. doi:10.3389/ fneur.2020.00444 3. Terrell D, Savardekar AR, Whipple SG, Sun H. In Reply to the Letter to the Editor Regarding "Cerebral Revascularization for Moyamoya Syndrome Associated with Sickle Cell Disease: A Systematic Review of Literature on the Role of ExtracranialIntracranial Bypass in Treating Neurologic Manifestations of Pediatric Patients with Sickle Cell Disease". World Neurosurg. 2020;138:583584.doi:10.1016/j.wneu.2020.03.162 4. Li B, Sun H, Zhang J. LncRNA DSCAM-AS1 promotes colorectal cancer progression by acting as a molecular sponge of miR-384 to modulate AKT3 expression. Aging (Albany NY). 2020;12(10):9781-9792. doi:10.18632/aging.103243 5. Taylor, BES, Khandelwal P, Rallo MS, Patel P, Smith L, Sun H, Nanda A, Singla A, Roychowdhury S, Cheng RC, Lee K, Gupta G, and Johnson S, Outcomes and Spectrum of Mamor Neurovascular Events Among Covid-19 Patients: a three-center experience, Neurosurgery Open, 2020, Accepted

Randall McKinnon, Ph.D. 1. McKinnon, RD (2021) Backdoor intrusion: retrotoxicity can explain targeted motor neuron death in amyotrophic lateral sclerosis. Neural Regen Res 16(7): 1448. 2. Liang, AS, Pagano JE, Chrzan CA, McKinnon RD (2021) Suicide transport blockade of motor neuron survival generates a focal graded injury and functional deficit. Neural Regen Res 16(7): 1281-1287.

Priyank Khandelwal, M.D. 1. Majmundar N, Ducruet A, Prakash T, Nanda A, Khandelwal P. Incidence, Pathophysiology, and Impact of Coronavirus Disease 2019 (COVID-19) on Acute Ischemic Stroke. World Neurosurg. 2020 Oct;142:523-525. doi: 10.1016/j.wneu.2020.07.158. PMID: 32987584; PMCID: PMC7510414. 2. Siegler JE, Zha AM, Czap AL, Ortega-Gutierrez S, Farooqui M, Liebeskind DS, Desai SM, Hassan AE, Starosciak AK, Linfante I, Rai V, Thon JM, Then R, Heslin ME, Thau L, Khandelwal P, Mohammaden MH, Haussen DC, Nogueira RG, Jillella DV, Nahab F, Kaliaev A, Nguyen TN, Zaidat O, Jovin TG, Jhadav AP. Influence of the COVID-19 Pandemic on Treatment Times for Acute Ischemic Stroke: The Society of Vascular and Interventional Neurology Multicenter Collaboration. 2021 Jan;52(1):40-47. doi: 10.1161/STROKEAHA.120.032789. Epub 2020 Nov 30. PMID: 33250041. 3. Bach I, Surathi P, Montealegre N, Abu-Hadid O, Rubenstein S, Redko S, Gupta S, Hillen M, Patel P, Khandelwal P, Kamel A. Stroke in COVID-19: a single-centre initial experience in a hotspot of the pandemic. Stroke Vasc Neurol. 2020 Dec;5(4):331-336. doi: 10.1136/svn-2020-000525. Epub 2020 Sep 24. PMID: 32973116; PMCID: PMC7517234 4. Patel P, Khandelwal P, Gupta G, Singla A. COVID-19 and cervical artery dissection-A causative association? Journal of Stroke and Cerebrovascular Diseases, 202neurointerventional surgery, 2020 5. Khandelwal P., Al Mufti F., Tiwari A. Incidence, Characteristics and Outcomes of Large Vessel Stroke in COVID-19 Cohort: Multicentric International Study. Incidence, characteristics and outcomes of large vessel stroke in COVID-19 cohort: a multicentric international study. Soc Sci Res Network. 2020:18.

John Gillick, M.D. 1. Dodson V, Majmundar N, Sharer LR, Gillick JL. Epidermoid Cyst of the Lumbar Spine After Lumbar Puncture: A Clinical, Radiographic, and Pathologic Correlation. World Neurosurg. 2020;137:363-366. doi:10.1016/j.wneu.2020.02.008 2. 2. Taylor BES, Hilden P, Behmer Hansen RT, Nanda A, Gillick JL. National Rates, Reasons, and Risk Factors for 30- and 90-Day Readmission and Reoperation Among Patients Undergoing Anterior Cervical Discectomy and Fusion: An Analysis Using the Nationwide Readmission Database. Neurosurgery. Submitted.

Pankaj Agarwalla, M.D. 1. Agarwalla PK, Koch MJ, Royce TJ, et al. Stereotactic Radiation as Salvage Therapy for Recurrent Rathke Cleft Cysts [published online ahead of print, 2020 Jan 13]. Neurosurgery. 2020;nyz523. doi:10.1093/neuros/nyz523

VOLUME 2

ISSUE 01

APRIL 2021

Highlighted Publications & Presentations in 2020 Continued

Amit Singla, M.D. 1. Tayebi Meybodi A, Singla A, Ren Z, Liu S. Concomitant Reversible Cerebral Vasoconstriction and Hyperperfusion Syndromes Following Carotid Endarterectomy. Cureus. 2020;12(6):e8541. Published 2020 Jun 9. doi:10.7759/cureus.8541 2. Towner JE, Li YI, Singla A, Moquin R, Li YM. Retrospective Review of Revision Surgery After Image-guided Instrumented Spinal Surgery Compared With Traditional Instrumented Spinal Surgery.Clin Spine Surg. 2020 Feb 11. doi: 10.1097/BSD.0000000000949. Online ahead of print. 3. Singla A, Ryan A, Bennett DL, Streit JA, Mau B, Rozek M, Hitchon PW.Non-infectious thoracic discitis: A diagnostic and management dilemma. A report of two cases with review of the literature.Clin Neurol Neurosurg. 2020 Mar;190:105648. doi: 10.1016/j.clineuro.2019.105648. Epub 2020 Jan 7.

Stephen Johnson, M.D. 1. Johnson SA, Kano H, Lunsford LD, et al. Gamma Knife for Vestibular Schwannomas: Long-Term Outcomes Over a 20-year Institutional Experience. JNO (epub ahead of print). 2. Taylor B, Khandelwal P, Rallo M, Patel P, Smith L, Sun H, Nanda A, Singla A, Roychowdhury S, Cheng R, Lee K, Gupta G, Johnson SA. Outcomes and Spectrum of Major Neurovascular Events Among Covid-19 Patients: A Three-Center Experience. Neurosurgery Open. (epub ahead of print) 3. McDowell MM, Agarwal N, Johnson SA, et al. Long Term Outcomes of Pediatric Arteriovenous Malformations: The 30-Year Pittsburgh Experience. J Neurosurg Pediatr [Epub ahead of print] 2020 4. Nowicki KW, Johnson SA, Goldschmidt E, et al. Visual Evoked Potentials and Intraoperative Awakening in Opthalmic Artery Sacrifice during Aneurysm Clipping: Two Cases and Literature Review. World Neurosurgery [Epub ahead of print] 2020.

Vineet Chitravanshi, Ph.D. 1. Ashraf O, Huynh T, Purnell B, Murugan M, Fedele DE, Chitravanshi V, Boison D. Suppression of phrenic nerve activity as a potential predictor of imminent sudden unexpected death in epilepsy (SUDEP). Neuropharmacology (accepted for publication)

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