CLINICAL PERFORMANCE
TREAT DRY EYE NATURALLY
Changes in the ocular surface after using OCULOCIN® PROPO eye drops in comparison with placebo for patients with chronic ocular surface diseases1 PATIENTS WITH INITIAL SCHIRMER'S TEST RESULTS LESS THAN < 10mm 1
OSMOLARITY TEST, mOSm/l 1
12
Eye friendly!
TEAR BREAK UP, sec 1
300
7
10
Safe!
Unique!
Natural!
Effective and practical!
6
8 5 6 4
4 2
Initial
3 days
7 days
350
Initial
3 days
7 days
Average OCULOCIN® PROPO
Average OCULOCIN® PROPO
15
AVERAGE
10 LOW
5
Initial
3 days
LEFT EYE
25
20
7 days
RIGHT EYE
30
Number of patients
Number of patients
MENISCUS HEIGHT TEST, PLACEBO, AVERAGE RESULTS1
LEFT EYE
HIGH
3 days
7 days
Average OCULOCIN® PROPO
RIGHT EYE
Initial
3 days
Average Placebo
25
0
Initial
Average Placebo
MENISCUS HEIGHT TEST, OCULOCIN® PROPO, AVERAGE RESULTS1 30
3
Average Placebo
HIGH
20 15
AVERAGE
10 LOW
5 0
7 days
Initial
3 days
7 days
Initial
3 days
7 days
CORNEAL AND CONJUCTIVAL DEFECT / DYNAMICS FOR EACH PATIENT, OCULOCIN® PROPO1 INITIAL
3 DAYS
7 DAYS
Level of defect
3.0 2.0 1.0 0.0
1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 6 1 2 3 4 5 6 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 6 1 2 3 4 5 6 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 6 1 2 3 4 5 Conjuctival diagram Corneal diagram Conjuctival diagram Corneal diagram Conjuctival diagram Corneal diagram
CORNEAL AND CONJUCTIVAL DEFECT / DYNAMICS FOR EACH PATIENT, PLACEBO1 INITIAL
3 DAYS
7 DAYS
Level of defect
3.0 2.0 1.0 0.0
1
*REFERENCES: 1. Rocha BA, Bueno PCP, Vaz MMDOLL, Nascimento AP, Ferreira NU, Moreno GDP, et al. Evaluation of a Propolis Water Extract Using a Reliable RP-HPLC Methodology and In Vitro and In Vivo Efficacy and Safety Characterisation. Evid. Based. Complement. Alternat. Med. [Internet]. 2013;2013:670451. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3655582&tool=pmcentrez&rendertype=abstract 2. Bogdanov S. Propolis: Composition , Health , Medicine: A Review. Bee Prod. Sci. 2015;1–40. http://www.bee-hexagon.net/files/file/fileE/Health/PropolisBookReview.pdf 3. Stanley MC, Ifeanyi OE, Eziokwu OG. Antimicrobial effects of Aloe vera on some human pathogens. 2014;3:1022–8. 4. Athiban PP, Borthakur BJ, Ganesan S, Swathika B. Evaluation of antimicrobial efficacy of Aloe vera and its effectiveness in decontaminating gutta percha cones. J. Conserv. Dent. [Internet]. 2012;15:246–8. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3410334&tool=pmcentrez&rendertype=abstract 5. Robson MC, Heggers JP, Hagstrom WJJ. Myth, Magic, Witchcraft, or Fact? Aloe vera Revisited. J. Burn Care Res. [Internet]. 1982;3:157–62. Available from: http://journals.lww.com/burncareresearch/Fulltext/1982/05000/Myth,_Magic,_Witchcraft,_or_Fact__Aloe_vera.5.aspx 6. EMEA. ASSESSMENT REPORT ON ALOE BARABADENSIS MILLER AND ALOE (VARIOUS SPECIES, MAINLY ALOE FEROX MILLER AND ITS HYBRIDS). 2007; 7. Pandey R, Mishra A. Antibacterial activities of crude extract of aloe barbadensis to clinically isolated bacterial pathogens. Appl. Biochem. Biotechnol. [Internet]. 2010;160:1356–61. Available from: http://www.ncbi.nlm.nih.gov/pubmed/19263248 8. Silva NCC, Barbosa L, Seito LN, Fernandes a. Antimicrobial activity and phytochemical analysis of crude extracts and essential oils from medicinal plants. Nat. Prod. Res. [Internet]. 2012 [cited 2015 Mar 24];26:1510–4. Available from: http://www.ncbi.nlm.nih.gov/pubmed/22007687 9. Ismail MC, Ibrahim KM, Lateef NS. Effect of Flower Extracts of Matricaria chamomilla L . on Some Bacteria Causing Eye Infections . Diyala J. fot Pure Sci. [Internet]. 2011; Available from: http://www.sciencesmag.uodiyala.edu.iq/uploads/Volume 7/Issue 3/English/97-123 E.pdf 10. Rayes AAH. Screening of Some Natural and Cultivated plants in Sudia Arabia Fight Infections And inhibit growth of pathogenic Bacteria. 2012;4:17–28. Available from: http://www.sciencepub.net/researcher/research0407/004_10147research0407_17_28.pdf 11. Gupta V, Mittal P, Bansal P, Khokra SL, Kaushik D. Pharmacological Potential of Matricaria recutita- A Review. Int. J. Pharm. Sci. Drug Res. [Internet]. 2010;2:12–6. Available from: http://www.ijpsdr.com/pdf/vol2-issue1/2.pdf 12. Kubiliene L, Laugaliene V, Pavilonis A, Maruska A, Majiene D, Barcauskaite K, et al. Alternative preparation of propolis extracts: comparison of their composition and biological activities. BMC Complement. Altern. Med. [Internet]. ???; 2015 [cited 2015 Dec 9];15:156. Available from: http://www.biomedcentral.com/content/pdf/s12906-015-0677-5.pdf 13. Ramanauskienė K, Marija A, Petrikaitė V, Briedis V. Total Phenolic Content and Antimicrobial Activity of Different Lithuanian Propolis Solutions. Evidence-Based Complement. Altern. 2013;2013. 14. Uzel A, Sorkun K, Önçağ Ö, Çoğulu D, Gençay Ö, Sali˙h B. Chemical compositions and antimicrobial activities of four different Anatolian propolis samples. Microbiol. Res. [Internet]. 2005 [cited 2015 Oct 22];160:189–95. Available from: http://www.sciencedirect.com/science/article/pii/S094450130500011X 15. Grange JM, Davey RW. Antibacterial properties of propolis (bee glue). J. R. Soc. Med. [Internet]. 1990;83:159–60. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1292560&tool=pmcentrez&rendertype=abstract 16. Hegazi A, Abdou AM, Allah FA. Antimicrobial activity of propolis on the bacterial causes of mastitis. Life Sci. J. [Internet]. 2014;11:572–6. Available from: http://www.scopus.com/inward/record.url?eid=2-s2.0-84901499551&partnerID=tZOtx3y1 17. M. Moricz A, Szarka S, G. Ott P, B. Hethelyi E, Szoke E, Tyihak E. Separation and Identification of Antibacterial Chamomile Components Using OPLC, Bioautography and GC-MS. Med. Chem. (Los. Angeles). 2012. p. 85–94. 18. Nejatzadeh-Barandozi F. Antibacterial activities and antioxidant capacity of Aloe vera. Org. Med. Chem. Lett. [Internet]. 2013;3:5. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3729540&tool=pmcentrez&rendertype=abstract 19. Ogbonnaya CI. A STUDY ON ANTIBACTERIAL ACTIVITIES OF ALOE VERA LEAVES , STEMS AND ROOTS ON SOME SELECTED ORGANISMS. 2013;5:52–9. Available from: http://www.cenresinpub.org/pubJune2013Ed/JBSB/Page 52-59 _023_.pdf 20. Ogawa T. United States Patent [ 19 ] U . S . Patent. 2000; 21. Stanojković A, Jelena Ceković, Ljiljana Čomić, Radmila Pivić, Stanojković A. ANTIBACTERIAL PROPERTIES OF SOME PLANTS FROM THE FAMILY ASTERACEAE GROWING WILD IN SERBIA. Orig. Sci. Pap. [Internet]. 2008;XXVI. Available from: http://www.mocbilja.rs/lekovitesirovine/pdf/2_Originalni_ls_26_27_02.pdf 22. Zandi K, Zadeh MA, Sartavi K, Rastian Z. Antiviral activity of Aloe vera against herpes simplex virus type 2: An in vitro study. African J. Biotechnol. [Internet]. 2007;6:1770–3. Available from: <Go to ISI>://000248685500007 23. N Kathuria, N Gupta, Manisha, R Prasad N. Biologic Effects Of Aloe Vera Gel. Internet J. Microbiol. [Internet]. 2010;9. Available from: http://ispub.com/IJMB/9/2/6161 24. Amoros M, Lurton E, Boustie J, Girre L, Sauvager F, Cormier M. Comparison of the anti-herpes simplex virus activities of propolis and 3-methyl-but-2-enyl caffeate. J. Nat. Prod. 1994;57:644–7. 25. Huleihel M, Isanu V. Anti-herpes simplex virus effect of an aqueous extract of propolis. Isr. Med. Assoc. J. IMAJ [Internet]. 2002;4:923–7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/12455181 26. K. Saoo, H. Miki MO andW. DW. Antiviral Activity of Aloe Extracts against Cytomegalovirus. Phyther. Res. [Internet]. 1996;10:348–50. Available from: https://www.researchgate.net/publication/230302776_Antiviral_Activity_of_Aloe_Extracts_against_Cytomegalovirus 27. Gavanji S, Asgari MJ, Vaezi R, Larki B. Antifungal effect of the extract of propolis on the growth of three species of Epidermophyton flucosum, Trichophyton violaseum and Trichophyton tonsorans in laboratory environment. African J. Pharm. Pharmacol. [Internet]. 2011;5:2642–6. Available from: http://www.academicjournals.org/AJPP/abstracts/abstracts/abstract 2011/29 December/Gavanji et al.htm 28. Fernandes FF, Dias ALT, Ramos CL, Ikegaki M, de Siqueira AM, Franco MC. The “in vitro” antifungal activity evaluation of propolis G12 ethanol extract on Cryptococcus neoformans. Rev. Inst. Med. Trop. Sao Paulo [Internet]. 2007;49:93–5. Available from: http://www.ncbi.nlm.nih.gov/pubmed/17505666 29. Shrivastava UKV. Antifungal activity of Aloe vera extract against pathogenic species of Aspergillus isolated from Kathmandu , Nepal [Internet]. 2014 [cited 2015 Dec 19]. Available from: http://www.aspergillus.org.uk/content/antifungal-activity-aloe-vera-extract-against-pathogenic-species-aspergillus-isolated 30. Özcan M. Antifungal properties of propolis. Grasas y Aceites. 1999;50:395–8. 31. Babaei A, Manafi M, Tavafi H. Study on Effect of Aloe vera Leaf Extracts on Growth of Aspergillus flavus. 2013;3:1091–7. Available from: http://sciencedomain.org/abstract/1945
1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 6 1 2 3 4 5 6 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 6 1 2 3 4 5 6 1 2 3 4 5 1 2 3 4 5 1 2 3 4 5 6 1 2 3 4 5 Conjuctival diagram Corneal diagram Conjuctival diagram Corneal diagram Conjuctival diagram Corneal diagram
This placebo controlled clinical trial (No. BEC-LSMU(R)-402) was performed in LHSU KC Hospital. There were 60 patients observed at initial visit, after 3 days and then after 7 days of treatment.
THIS INFORMATIONAL BROCHURE IS NOT FOR PUBLIC. ONLY FOR MEDICAL PROFESSIONALS. OCULOCIN® PROPO IS A MEDICAL DEVICE CLASS PRODUCT. OBSERVATIONS, SCIENTIFIC REPORTS, OTHER DATA COLLECTED AND PRESENTED HERE IS FOR REFERENCE AND CRITICAL EVALUATION OF PROFESSIONAL USERS ONLY.
Preservative free!
No antibiotics!
No aggressive active ingredients!
100%
80%
80%
80%
60%
60%
60%
40%
40%
40%
20%
20%
20%
0%
Initial
In 21 day TBUT
0%
Sensitivity to light
Fereign Body sensation
Schirmer test
0%
Burning
In 21 day
Conjunctival Injection Conjunctival swelling
Initial
73%
Eye lid swelling
In 21 day
Initial
PATIENTS LOVE OCULOCIN® PROPO
PROTECTION AND RECOVERY
nt improvem a c i en if n t g
RELIEF OF SYMPTOMS2
100%
100%
t improvem n a c en ifi n t g
t improvem n a c en ifi t n g
sease repo r t e di si fac
and ma rec
RELIEF OF NEGATIVE PATIENT'S SENSES2
ys1. Patien a d 7 ts in
hronic ocul a r su th c wi
97%
43% INCREASEMENT IN LUBRICATION AND QUALITY2
ys1. Patien a d 3 ts in
hronic ocul a r su th c wi
Long te rm
Changes in the ocular surface of patients prescribed OCULOCIN® PROPO eye drops for patients with endocrine ophthalmopathy2
1 . Patie s y a d nts 7 in
hronic ocular s th c u r wi
Sh s u o rt t e r m ular rfa c e p r oc i o n ote ct
NATURALLY EFFECTIVE • CLINICALLY PROVEN
disease repo r t ce si rfa
Im
l u b ri c a ti o n ia te rt ed comfo m and
ent m e g na ery ov
CLINICAL PERFORMANCE
97% disease repo r t ce si rfa
TRIPLE ACTION FOR OCULAR SURFACE DISEASE
WORLD’S BEST PACKAGE FOR BEST PRODUCT
OPINION SURVEY3 RESEARCH INDICATED POSITIVE ACTIVITY ON MOST COMMON CONTAMINANTS*
8
Staphylococcus aureus
PROPOLIS is a special type of bee wax specifically used for protection of bee hives from surrounding factors. It’s been used for centuries worldwide for various health issues. Many scientific studies have indicated its antibacterial, anti-inflammatory, pain relief and immune stimulating abilities. Rich in polyphenols and other components, this natural ingredient may play an important role in protection of the ocular surface.*
ALOE VERA
Staphylococcus epidermidis
6
4
Serratia marcescens 2
Corynebacterium sp Leptospira spp.
Immediate relief Random antibiotic treatment
Pseudomonas aeruginosa
Long term comfort
Random lubricant incl. Hyaluronic acid and hypromellose
Symptomatic relief
Random herbal incl. Euphrasia
Lubrication
Random homeopatic
Relief from excessive tearing
Random antiinflamatory (SAID, NSAID)
OCULOCIN® PROPO
OPHTHALMOLOGISTS LIKE OCULOCIN PROPO ®
Proteus vulgaris Citrobacter freundii
Resealable and leak proof! May be safely used 24 hours after opening! Extremely convenient! Take out exactly how much you need. Share with family safely without cross contamination risk. Even dropper tip is safer for accidental touch to eye surface. Super economic value! Use only how much you need for the moment and leave what is left for next time within full expiration date period. Buy one package and share small dose container with family and friends in need. Friendly liquids for airport regulations. Preservative free!
MOST COMMON Q&A
OPINION SURVEY3 15
Adenovirus 12
Herpes simplex Varicella zoster Poliovirus Cytomegalovirus
9
6
3
Candida albicans Cryptococcus neoformans
CHAMOMILE (lat. Chamomilla Matricaria) is one of the most well-known and used plant. Containing alfa-bisabolos and azulens among other components this plant is indicated as a spasmolytic and antiseptic within scientific studies. This natural ingredient may play an important role in protection and comfort of the ocular surface.*
Short term comfort
Escherichia coli Micrococcus flavus
Quantity of answers
CHAMOMILE
0
Haemophilus influenzae
Proteus mirabilis
ALOE (lat. Aloe Vera) is a well-known and widely used plant known for its lubricating and protective abilities. Many scientific studies have indicated its ability to relieve and restore. Containing aloins and emodins among others, it’s indicated for recovery and comforting, also in fighting various inflammations. This natural ingredient may play an important role in the comfort and protection of the ocular surface.*
Streptococcus pneumoniae Evaluation score
PROPOLIS
10
0 Complementary to long term therapies
Aspergillus niger
Prevention of symptoms in contact lens wearers
Extencive eye fatigue
DES Lubricants
Aspergillus flavus Aloe
Chamomilla
Propolis
2 3
Chronic ocular surface disease Homeopathic
Other herbal
OCULOCIN® PROPO
This observation is made by Prof., M. D. Ophthalmologist Jurate Jankauskiene and ophthalmologist Dalia Jarušaitiene. There were 38 patients observed at initial visit and after 21 day of treatment. Source is ORIGMED research file, v201506.
When to prescribe OCULOCIN® PROPO? OCULOCIN® PROPO works in various chronic conditions. It shows good results as a complement to other long term therapics - for example glaucoma treatment, when extensive use of traditional pharmaceuticals irritates the ocular surface. OCULOCIN® PROPO should be strongly considered for all contact lens wearers who are of higher risk of contamination and ocular surface complications. OCULOCIN® PROPO is a “must” in every home’s first aid kit for challenging situations: yard work, holidays, planes, seaside, pools, sports, extensive use of mobile devices, TV etc.
Is OCULOCIN® PROPO safe? OCULOCIN® PROPO is preservative free. It can be used as much as needed. No side effects are observed or reported. However, we did not test it as hypoallergenic product so people with allergies must be cautious and check the ingredients. Can OCULOCIN® PROPO be used for children? OCULOCIN® PROPO was not tested in children, so doctors must be cautious in children below 3 years old. Can OCULOCIN® PROPO be used for contact lens wearers? Yes, it can. However, for better efficacy, we recommend the use of OCULOCIN® PROPO without contact lenses since it is a physical barrier between the eye drops and cornea.