by Mark HumphriesThe Spike

FORTHCOMING TITLES

THE SPIKE An Epic Journey Through the Brain in 2.1 Seconds MARK HUMPHRIES

A brilliant overview of our current understanding of brain function, from perception to action, based on our knowledge of systems neuroscience. Conveying ideas and concepts with impressive clarity, Humphries covers an astonishing amount of scientific literature. A joy to read – Matthias Hennig, University of Edinburgh

An original snapshot of how the brain works that takes readers to the cutting edge of neuroscience research.

Our brains use electricity to communicate. Each nerve cell, each neuron, talks to other neurons by sending a tiny blip of voltage down a gossamer-thin cable. Neuroscientists call that blip ‘the spike’. And spikes are how we do anything: talk, eat and run; see, plan and decide.

In THE SPIKE, Mark Humphries takes us on the journey of a single spike in a single act, from seeing to thinking to moving. Even in these few seconds, more than 10 billion spikes will fire all across the brain. As he follows just one spike across just a few moments in time, we meet dark neurons, the literal silent majority, who sit unmoved by anything and everything going on around them. They are invisible to neuroimaging, and challenge our most deeply held theories of what neurons do. We meet spontaneous spikes: spikes created by neurons without any input from the outside world; spikes created solely by the myriad feedback loops between neurons that drive each other to spike endlessly. Crazier still are spikes born without any input even to the neuron that created them, spikes created solely by the internal cycling of molecules inside a neuron. We encounter layers upon layers of mystery and wonder and almost unimaginable complexity.

New technologies have begun to draw back the curtain on this neuronal drama, and every day new research upends our understanding of how neurons talk to each other. Of how we see, of how we decide, of how we move. But until now we've had no big-picture narrative; no story of how all our discoveries fit together. THE SPIKE tells that story.

MARK HUMPHRIES is a professor of computational neuroscience at the University of Nottingham, where he holds a prestigious seven-year senior fellowship from the UK’s Medical Research Council – the only computational scientist ever to have been awarded one. Before moving to Nottingham in 2018, he was a senior research fellow at the University of Manchester, a fellow at École Normale Supérieure in Paris and a postdoctoral and PhD student at the University of Sheffield. His work has been published in leading scientific journals including Neuron, eLife and Nature Communications. In 2016 he founded the Medium publication ‘The Spike’ to bring the unheralded golden age of systems neuroscience to the general public. His stories there have amassed close to half a million views in the publication’s first two years.

Agent: Jeff Shreve

Publisher: Princeton University Press Publication: Autumn 2020 Status: Manuscript Length: 60,000 words

All rights available excluding World English Language (Princeton University Press)

FORTHCOMING TITLES

THE CENTURY OF DECEPTION The Birth of the Hoax in Eighteenth-Century England IAN KEABLE

‛Fake news’, ‛going viral’ and ‛social media’ may be phrases from the twenty-first century but the concepts were all born in a series of absurdist events some 250 years ago.

England, 1749. A newspaper advertisement appears stating that a man will climb inside a bottle on the stage of a London theatre. Unfortunately, although the audience turns up, the conjurer doesn’t. Earlier in the same century a woman said she was giving birth to rabbits; later a new Shakespearian play was supposedly discovered and performed – like the Bottle Conjurer for one night only.

In THE CENTURY OF DECEPTION the magician and historian of conjuring Ian Keable tells the stories of these and several other eighteenth-century hoaxes including a sociopathic liar, a hilarious astrological prediction, a rapping ghost and a Frenchman attempting to go airborne in a Chinese temple.

Hoaxes, of course, have always been around. But this was the era when they were first extensively reported, vividly depicted and reliably described – as well as forensically investigated. They were also widely influential, drawing in many celebrities of the day such as Samuel Johnson, Benjamin Franklin and Jonathan Swift and inflaming concerns about ‘English credulity’.

Embracing history and society, literature and the theatre, medicine and religion, satirical prints and paintings, imprisonment and capital punishment, and questions of ‘whodunit’ and ‘whydunit’, this entertaining and eye-popping book reveals how these hoaxes provide the perfect mirror for reflecting universal truths about our susceptibility to being duped.

IAN KEABLE obtained a first-class degree from the University of Oxford in philosophy, politics and economics, qualified as a chartered accountant and then became a professional magician. A member of The Magic Circle with gold star, he has won several awards for his unique brand of comedy magic and is the author of three books for the general public as well as three works for professionals including Stand-Up: A Professional Guide to Comedy Magic and Charles Dickens Magician: Conjuring in Life, Letters and Literature. He has made numerous appearances on television including ‘New Faces’, the predecessor to ‘Britain's Got Talent’, and has written and presented programmes for BBC Radio. An accredited lecturer for The Arts Society, he gives talks on cartoons, satirical prints and eighteenth-century hoaxes. He still performs as a magician at corporate events and private parties and also does a show about Dickens's interest in conjuring and spiritualism. He is married with two children and lives in London.

Agent: Peter Tallack

Publisher: Westbourne Press Publication: 7 October 2021 Status: Manuscript Length: 80,000 words

All rights available excluding UK & Commonwealth (Westbourne Press)

FORTHCOMING TITLES

OUCH! Why Pain Hurts and Why It Doesn’t Have To MARGEE KERR & LINDA RODRIGUEZ MCROBBIE

Whether you’re suffering from chronic pain or simply curious about the workings of the human body and mind, this book will change the way you think about this fundamental human experience that, directly or indirectly, affects us all.

From the mounting casualties of the opioid crisis to doctors downplaying and misdiagnosing patients’ suffering, we clearly have an increasingly dysfunctional relationship with pain. As children we’re taught to avoid pain at all costs and rely on painkillers to dull even the mildest of aches. Yet this strategy of avoidance and suppression has unexpectedly resulted in our feeling worse.

The first step to feeling better, argue Margee Kerr and Linda Rodriguez McRobbie, is to stop being scared and lean into the pain. In OUCH!, they reveal that pain is a rich, layered experience governed not only by the signals tripped the moment a needle pricks our skin but also by where we are, who we’re with, why we’re there, and our individual history. By understanding the complexity of how pain is made, we can learn in many cases how to reduce the perceived intensity of pain as well as recast and transform the negative emotions –the fear and helplessness – associated with it.

On their journey Kerr and McRobbie seek out pain-sensing robots and pain-seeking parishioners, explore burning bug bites and blissful lashings and witness for themselves – at the Tough Mudder, a team-oriented 18–20-kilometre obstacle course designed to test physical strength and mental grit – the power of pain to bring people together. Ultimately, OUCH! offers us a deeper understanding of this incredibly subjective yet universal experience, revealing a truth we instinctively know: not all pain is bad, not all pain is harmful. As they discover, pain can be not just useful, but even rewarding.

Through immersive reporting, in-depth interviews and original research, adventure to discover that pain is not just something that happens to us, control over our experience than we think. OUCH! takes us on an and that we have more

MARGEE KERR is a sociologist who has been teaching and conducting research since 2004. The author of SCREAM: Chilling Adventures in the Science of Fear (PublicAffairs, 2015), she holds a PhD from the University of Pittsburgh. Her writing has appeared in the New York Times, Slate, Salon and the New York Post, among other publications. She lives in Philadelphia.

LINDA RODRIGUEZ McROBBIE is a freelance writer and journalist specializing in science, culture and history. Her work has appeared in the Guardian, Smithsonian Magazine, the Boston Globe, Slate, Atlas Obscura and other outlets. She is the author of PRINCESSES BEHAVING BADLY: Real Stories from History Without the Fairy-Tale Endings (Quirk Books, 2013). She lives in London.

Agent: Tisse Takagi

Publisher: Bloomsbury Sigma Publication: January 2021 Status: Proofs Length: 90,000 words