New Title Alert Regulating with RNA In Bacteria and Archaea ISBN: 978-1-683-67023-0 November 2018 ASM Press List Price £116.00
“Finally! One spectacular volume provides us all we need to educate ourselves in the fascinating world of regulatory RNAs in bacteria and archaea. This volume is an eye-opening must read about one of microbiology’s most exciting emerging fields.” -Bonnie Basler, Princeton University
Revealing the many roles of RNA in regulating gene expression. For decades after the discoveries of messenger RNA, transfer RNA, and ribosomal RNA, it was largely assumed that the role of RNA in the cell was limited to shuttling the genomic message, chaperoning amino acids, and toiling in the ribosomes. Eventually, hints that RNA molecules might have regulatory roles began to appear. With the advent of genomics and bioinformatics, it became evident that numerous other RNA forms exist and have specific functions, including small RNAs (sRNA), RNA thermometers, and riboswitches to regulate core metabolic pathways, bacterial pathogenesis, iron homeostasis, quorum sensing, and biofilm formation.
All of these functions, and more, are presented in Regulating with RNA in Bacteria and Archaea, written by RNA biologists from around the globe. ISBN 9781683670230 e-ISBN 9781683670247 Hardcover or ebook, 593 pgs, index. Key Selling Points: Divided into eight sections—RNases and Helicases, Cis-Acting RNAs, Cis Encoded Base Pairing RNAs, Trans-Encoded Base Pairing RNAs, Protein Titration and Scaffolding, General Considerations, Emerging Topics, and Resources. Catering to principle investigators, postdocs and advanced students alike, this book gives a comprehensive account of the state-of-the-art of the prokaryotic RNA inventory and underlying molecular mechanisms. Several chapters are focused on general aspects of bacterial gene expression that are crucially relevant to our understanding of the activities and consequences of RNA-based regulation.
Gisela Storz is an NIH Distinguished Investigator in the Eunice Kennedy Shriver National Institute of Child Health and Human Development in Bethesda, Maryland. She carried out graduate work with Dr. Bruce Ames at the University of California, Berkeley and postdoctoral work with Dr. Sankar Adhya at the National Cancer Institute and Dr. Fred Ausubel at Harvard Medical School. As a result of the serendipitous discovery of the peroxideinduced OxyS RNA in E. coli, one of the first small, regulatory RNAs to be found, much of the work in her lab has focused on the genome-wide identification of small RNAs and their characterization.
Kai Papenfort is a Professor of Microbiology at the Ludwig Maximilians University of Munich, Germany. He received a diploma in biology from the University of Marburg and carried out graduate work with Dr. JĂśrg Vogel at the Max Planck Institute for Infection Biology and the Humboldt University of Berlin. In his postdoctoral work at the University of WĂźrzburg and Princeton University, Dr. Papenfort studied the regulatory functions of small RNA in bacterial pathogens and their involvement in bacterial communication processes such as quorum sensing. His laboratory focuses on the molecular mechanisms underlying the regulation by small RNAs in the major human pathogen, Vibrio cholerae.