CLARIFIDE® PLUS OFFERS INNOVATIVE GENETIC PREDICTIONS FOR DAIRY WELLNESS TRAITS • Prevention and treatment of events that adversely impact animal health require dairy producers to invest significant time, energy and finances, not to mention the cost of lost production and the risk of mortality • CLARIFIDE® Plus from Zoetis offers dairy producers the opportunity to more accurately identify and select animals based on wellness traits including mastitis, lameness, metritis, retained placenta, displaced abomasum and ketosis • In addition to individual trait results, CLARIFIDE Plus provides two indexes—Dairy Wellness Profit Index™ (DWP$™) and Wellness Trait Index™ (WT$™)—that describe differences in lifetime profitability including the new wellness trait genetic information
IMPACT OF HEALTH EVENTS Incidence/Lactation Range Cost ($) per Case Culling Risk1 Mastitis
12 – 40% 1,2,3,4,8,13 2,4,6,13
Lameness
10 – 48%
Metritis
2 – 37% 1,3,10,11,13
Retained Placenta Displaced Abomasum Ketosis
5 – 15% 3 – 5%
1,2,3,4,11,12
1,2,3,4,13
5 – 14%
1,3,4,13
$155 – 224 4,8,9 $177 – 469
4,7
$300 – 358 10,11 $206 – 315 $494
4,12
4
$117 – 289
32.7 162 17.1 31.7 26.9
4,5
32.5
BACKED BY MILLIONS OF U.S. COMMERCIAL COW RECORDS DEVELOPMENT OF FIRST U.S.-BASED DAIRY WELLNESS GENOMIC PREDICTIONS HELPS IDENTIFY MORE TROUBLE-FREE COWS “The new tools developed
CLARIFIDE Plus offers U.S. Holstein producers a
• Wellness Trait Index™ (WT$™): This selection index
simple, comprehensive way to combine wellness
focuses exclusively on the wellness traits (mastitis,
by Zoetis with CLARIFIDE
and other genetic trait predictions into economic-
lameness, metritis, retained placenta, displaced
Plus provide us with more
based indexes that measure profitability based on
abomasum, ketosis and polled) and estimates
detailed information about
direct genetic predictions for adverse health events.
expected differences in lifetime profitability
health and wellness. This will
Always passionate about customer success, Select
allow Select Sires to more
Sires is collaborating with Zoetis to provide two
directly develop genetics
innovative indexes for its Holstein sires.
related to them. The top WT$ sires at Select Sires will be designated WellnessPRO™ to identify the sires with the greatest chance to make a positive impact on wellness by
that improve the overall
These indexes include:
reducing the genetic risk of common dairy cow
fitness of dairy cows.”
• Dairy Wellness Profit Index™ (DWP$™): A multi-
diseases.
trait selection index which includes production, Chuck Sattler Vice President Genetic Programs Select Sires Inc.
fertility, type, longevity and the wellness traits, including Polled test results.
BASED ON A LARGE, INDEPENDENT U.S. COMMERCIAL HERD DATABASE Zoetis developed the genomic predictions for wellness traits based on an independent database of pedigrees, genotypes, and production and health records assembled from records of nearly 20 million health events from U.S. commercial dairies and internal assets. Wellness traits are expressed as Standard Transmitting Ability (STA), where 100 represents average expected disease risk. Higher values are desirable for all traits.
AVERAGE RELIABILITY AND AVERAGE, MINIMUM AND MAXIMUM GENETIC VALUES FOR WELLNESS TRAITS* Average Score
Minimum Score
Maximum Score
Mastitis
100
76
115
Lameness
100
73
115
Metritis
100
75
115
Retained Placenta
100
71
116
Displaced Abomasum
100
69
111
Ketosis
100
72
113
Dairy Wellness Traits
*Numbers reflect data from reference population of animals under two years of age Source: Data on file, Zoetis internal data, August 2015, Zoetis Inc. 1. Gröhn YT, et al. Effect of Diseases on the Culling of Holstein Dairy Cows in New York State Journal Dairy Sci 1998;81(4):966-978. 2. Bar D, Gröhn YT, Bennett G, González R, Hertl J, Schulte H, Tauer L, Welcome F, Schukken Y. Effect of repeated episodes of generic clinical mastitis on milk yield in dairy cows. Journal Dairy Sci 2007;90(10):4643-4653. 3. Guard C. The costs of common diseases of dairy cattle, in Proceedings. CVC in San Diego 2008a. 4. McArt JAA, et al. Hyperketonemia in early lactation dairy cattle: a deterministic estimate of component and total cost per case. J of Dairy Sci 2015;98(3):2043-2054. 5. Bicalho RC. Lameness in Dairy Cattle: A debilitating disease or a Disease of Debilitated Cattle? in Proceedings. Western Dairy Management Conference, 2011;73-83. 6. Clarkson MJ, Downham DY, Faull WB, Hughes JW, Manson FJ, Merritt JB, Murray RD, Russell WB, Sutherst JE, Ward WR. Incidence and prevalence of lameness in dairy cattle. Vet Rec 1996;138:563-567. 7. Cha E, Hertl J, Bar D, Gröhn YT. The cost of different types of lameness in dairy cows calculated by dynamic programming. Preventive Veterinary Medicine 2010;97(1):1-8. 8. Cha E, Bar D, Hertl J, Tauer L, Bennett G, González R, Schukken Y, Welcome F, Gröhn YT. The cost and management of different types of clinical mastitis in dairy cows estimated by dynamic programming. Journal Dairy Sci 2011;94(9):4476-4487. 9. The Value of Uterine Health: the Diseases, the Causes, and the Financial Implications. Article. Dairy Cattle Reproduction Council. 10. Overton M, Fetrow J. Economics of postpartum uterine health, in Proceedings. Dairy Cattle Reproduction Council Convention 2008;39-44. 11. Guard C. Retained Placenta: Causes and Treatments. Advances in Dairy Technology 1999;11:81. 12. Jones WP, Hansen LB, Chester-Jones H. Response of health care to selection for milk yield of dairy cattle. Journal of Dairy Science 1994;77:3137-3152. 13. Zwald NR, Weigel KA, Chang YM, Welper RD, Clay JS. Genetic Selection of Heath Traits using Producer-Recorded Data. I. Incidence Rates, Heritability Estimates, and Sire Breeding Values. J of Dairy Sci 2004;87:4287-4294. All trademarks are the property of Zoetis Inc., its affiliates and/or licensors. All other trademarks are the property of their respective owners. © 2016 Zoetis Inc. All rights reserved. CLR-00115
CLARIFIDE® PLUS INDEXES PROVIDE POWERFUL SELECTION TOOLS CLARIFIDE Plus is a first-of-its-kind genomic test
The final product reflects their invaluable input and
that delivers information on six wellness traits—
knowledge regarding animal breeding and producer
mastitis, lameness, metritis, retained placenta,
application of genetic technology. The following
displaced abomasum and ketosis—previously
chart depicts the general categories included in
KEY TAKEAWAYS:
unavailable to dairy producers in one comprehensive
DWP$ and the weights included within the index.
• Wellness Trait Index™ (WT$™)
offering. Zoetis developed the Wellness Trait Index
places economic weights
DWP$ Relative Value (%)
(WT$) and Dairy Wellness Profit Index (DWP$) to
on wellness traits, directly
provide the appropriate weighting and economic
estimating potential profit
relevance to these trait predictions while helping
contribution of these traits Wellness 30%
dairy producers utilize these new wellness traits in effective genomic herd strategies (and protocols).
for an individual animal. Production 34%
When selecting mating sires, the WT$ index can be added to your regular selection
INSIDE WT$ AND DWP$
criteria (for example: TPI,
Type 10%
WT$ is made up of the six new wellness traits and the economic impact of each trait on expected
Udder Composite, Feet and Leg Composite) when you
profitability outcomes. The chart below depicts the
Fertility 7%
traits included in WT$ and the associated weighting. WT$ Relative Value (%)
wish to include wellness
Health & Calving 19%
criteria.
*DWP$ also includes the economic value for polled.
DWP$ describes variation in expected profitability of dairy animals attributed to differences in genetic
Lameness 27%
potential for production, fertility, longevity and risk Mastitis 41%
of disease. The index differs from other economic indexes by including direct predictions for health
Ketosis 1%
events that have significant economic implications.
• Dairy Wellness Profit Index™ (DWP$™) includes information provided from WT$ with additional wellness trait information. Similar to TPI and NM$, DWP$ can be used as the primary index by producers preferring
DA 6% RP 6%
By including more characteristics affecting
to begin their sire search
profitability, DWP$ describes more genetic variation
using a single value.
in profitability than other indexes.
Metritis 19%
• Selection for DWP$ can result
The more variation present within the population for
*WT$ also includes the economic value for polled.
an index or trait of interest, the greater the impact of Like WT$,™ DWP$™ includes wellness traits but
percentile and bottom 10th
performance and additional profitability outcomes
Dairy Wellness Profit Index (DWP$)
such as fertility, longevity and calving ability.
and provide DWP$ and
comparable to other well-known selection
WT$ indexes. The top WT$ ~$256 DWP$
indexes such as Net Merit (NM$) and Total Performance Index® (TPI™). This similarity
~$256 DWP$
sires will be designated as WellnessPRO.
makes DWP$ a practical consideration for
~$624 DWP$
~$624 DWP$
producers who have historically used either index, but would like to apply additional selection emphasis on wellness traits.
indexes, the weights and economic inputs. In addition, a team of dairy industry experts reviewed the DWP$ outcomes and foundational components.
percentile of ranked animals.1 • Select Sires will test all bulls
The use of DWP$ offers selection emphasis
publications informed the development of both
profitability of more than $1,200 between top 10th
selection decisions.
also covers important productivity traits impacting
An extensive review of peer-reviewed
in a difference in lifetime
10th
30th
50th Percentile
70th
90th (Top 10th Percentile)
DWP$ Breeding Value BV = $483 The chart above shows the expected difference in lifetime profitability between the top 10th percentile and bottom 10th percentile animals ranked by DWP$ in a given population is more than $1,200.
IMPROVE HERD HEALTH BY CHOICE, NOT CHANCE. SELECT WellnessPRO™ SIRES WellnessPRO sires are Identified using the Wellness Trait Index (WT$) through CLARIFIDE Plus genomic testing. WT$ focuses on the wellness traits (mastitis, lameness, metritis, retained placenta, displaced abomasum, ketosis and polled) and estimates expected differences in lifetime profitability related to them. WellnessPRO identifies Select Sires’ best WT$ sires.
SELECT SIRES DAUGHTER-PROVEN SIRES CODE NO.
CODE NAME
7HO11567
MIDLAND
DWP$ INDEX
+909
SELECT SIRES SUPER SAMPLERS WT$ INDEX
DWP$ INDEX
WT$ INDEX
CODE NO.
CODE NAME
+272
7HO12782
BONJOUR
+1124
+270
PAGEONE
+1067
+249
7HO11123
WRIGHT
+830
+248
7HO12556
7HO11777
SNOWMOBIL
+747
+238
7HO13277
BOWIE
+983
+249
7HO12569
HEISENBERG
+955
+242
7HO12472
ALCO
7HO12482
GAYLORD-P
7HO12111 7HO12571 7HO12574
MIDGARD
7HO12667
BORIS-RED
7HO11741
MOCHA
+836
+218
7HO10920
GOLD CHIP
+273
+203
+1006
+225
+706
+216
DRAGONHEART
+880
+208
HEINZ
+976
+199
7HO10233
MIZZOU
+577
+192
7HO11833
RENNIE
+1049
+191
7HO11519
RACKET
+937
+188
7HO11169
PETRONE
+792
+178
7HO11283
MAYFIELD
+613
+169
7HO12773
KENOSHA
+638
+193
7HO10723
SPUR
+501
+164
7HO12550
FARRIS
+980
+190
7HO11195
KENNARD
+509
+152
7HO12602
HANG-TIME
+1045
+189
7HO11621
MAYFLOWER
+958
+149
7HO12601
FRANCHISE
+1030
+188
7HO10700
MAUSER
+572
+136
7HO13195
PROFIT
+1037
+188
+130
7HO12721
EXACTLY
+984
+178
7HO13238
TOM
+856
+170
7HO12814
TRUE PP
+865
+162
7HO12198
KINGBOY
+809
+158
7HO12582
FERGAL
+876
+158
7HO13140
SYNERGY
+830
+156
7HO13322
CHANNING
+1056
+154
7HO12615
SCENARIO
+971
+153
7HO13159
FOXSONG
+807
+151
7HO13216
MESSAGE
+790
+151
7HO12740
SUN DADDY
+892
+150
7HO11488
BRANSON
+641
GENERVATIONS DAUGHTER-PROVEN SIRES CODE NO.
CODE NAME
250HO1002 EPIC
DWP$ INDEX
+639
WT$ INDEX
+131
GENERVATIONS YOUNG SIRES CODE NO.
CODE NAME
DWP$ INDEX
WT$ INDEX
250HO12563 ANCHORMAN
+837
+169
250HO1131 SALT
+912
+160
For more information about Select Sires’ WellnessPRO sires and a complete listing of traits, visit www.selectsires.com.
™WellnessPRO and FertilityPRO are trademarks of Select Sires Inc. ®TPI is a registered trademark of Holstein Association USA.
+1009
+199
+818
+195
FERTILITY PRO™ SIRES DWP$ INDEX
WT$ INDEX
CODE NO.
CODE NAME
7HO12189
DJANGO
7HO12197
UPTOWN
+847
+188
7HO12432
RAYNOR
+793
+151
+804
+191