Clinical trials

Your doctor may ask you whether you would like to take part in a clinical trial. This is a research study conducted with patients in order to (ClinicalTrials.gov 2017):

Test new treatments. Look at new combinations of existing treatments or change the way they are given to make them more effective or reduce side effects. Compare the effectiveness of drugs used to control symptoms. Find out how cancer treatments work.

Clinical trials help to improve knowledge about cancer and develop new treatments and there can be many benefits to taking part. You would be carefully monitored during and after the study and the new treatment may offer benefits over existing therapies. It’s important to bear in mind, however, that some new treatments are found not to be as good as existing treatments or to have side effects that outweigh the benefits (ClinicalTrials.gov 2017).

Clinical trials help to improve knowledge about diseases and develop new treatments – there can be many benefits to taking part

Several new drugs for the treatment of cervical cancer are now entering clinical trials, including immunotherapy agents, which stimulate the body’s immune system to fight cancer cells. Nivolumab, an immunotherapy drug which blocks a protein called programmed cell death protein 1 (PD-1) on the surface of some immune cells, has shown encouraging results in patients with cervical cancer (Hollebecque et al. 2017). Pembrolizumab, which is also a PD-1 inhibitor, was recently approved for use as a treatment for cervical cancer in the US, based on the results of recent clinical trials. Pembrolizumab is approved in the US for use in patients with recurrent or metastatic cervical cancer that has progressed after chemotherapy treatment, and whose tumours have high levels of a protein called programmed death-ligand 1 (PD-L1) (Keytruda PI, 2018).

You have the right to accept or refuse participation in a clinical trial without any consequences for the quality of your treatment. If your doctor does not ask you about taking part in a clinical trial and you want to find out more about this option, you can ask your doctor if there is a trial for your type of cancer taking place nearby (ClinicalTrials.gov 2017).