OPEN CLINICAL TRIALS

RESOURCES

OPEN CLINICAL TRIALS IN SONOMA COUNTY 2022

This list of open, FDA-approved clinical trials in Sonoma County is intended to increase awareness of local medical research and to benefit physicians who may wish to refer patients. Organized by condition, each listing includes basic information about who may be eligible and what medical provider is conducting the study. As this list is subject to frequent changes, please contact the individual research groups or your primary care provider for the latest information (contacts listed on page 78). Source: www.clinicaltrials.gov (Dec. 1, 2021)

ALZHEIMER’S / DEMENTIA NCT05026866: A Donanemab (LY3002813) Prevention Study in Participants with Preclinical Alzheimer’s Disease (TRAILBLAZER-ALZ 3); Phase III

Age: 55 years to 80 years Location: Providence Medical Foundation, Santa Rosa, Calif. and more (national)

CANCER Anal cancer

NCT04444921: EA2176: Trial of Carboplatin and Pacliitaxel +/- Nivolumab in Metastatic Anal Cancer Patients; Phase III

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Rohnert Park Cancer Center, Rohnert Park, Calif. and more (national)

Bladder cancer

NCT03288545: A Study of Enfortumab Vedotin Alone or with Other Therapies for Treatment of Urothelial Cancer; Phase I, Phase II

Age: 18 years and older Location: Providence Medical Foundation, Santa Rosa, Calif. and more (international)

NCT04637594: Trying to Find the Correct Length of Treatment with Immune Checkpoint Therapy; Phase III

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Rohnert Park Cancer Center, Rohnert Park, Calif. and more (national)

Blood cancers

NCT04071457: S1803, Lenalidomide +/- Daratumumab/ rHuPh20 as Post-ASCT Maintenance for Multiple Myeloma w/MRD to Direct Therapy Duration; Phase III

Age: 18 years to 75 years Location: Kaiser Permanente, Santa Rosa, Calif.; Rohnert Park Cancer Center, Rohnert Park, Calif. and more (national)

NCT03150693: Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults with Newly Diagnosed B Acute Lymphoblastic Leukemia; Phase III

Age: 18 years to 39 years Location: Kaiser Permanente, Santa Rosa, Calif.; Rohnert Park Cancer Center, Rohnert Park, Calif. and more (North America)

NCT03893682: A Study of CG806 in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia / Small Lymphocytic Lymphoma or Non-Hodgkin’s Lymphomas; Phase I

Age: 18 years and older Location: Providence Medical Foundation, Santa Rosa, Calif. and more (national)

NCT03269669: Obinutuzumab with or without Umbralisib, Lenalidomide, or Combination Chemotherapy in Treating Patients with Relapsed or Refractory Grade I-IIIa Follicular Lymphoma; Phase II

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Sutter Pacific Medical Foundation, Santa Rosa, Calif. and more (national)

NCT01896999: Brentuximab Vedotin and Nivolumab with or without Ipilimumab in Treating Patients with Relapsed or Refractory Hodgkin Lymphoma; Phase I, Phase II

Age: 12 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Rohnert Park Cancer Center, Rohnert Park, Calif. and more (national)

Brain and spinal cancers

NCT02179086: Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients with Newly Diagnosed Glioblastoma; Phase II

Age: 18 years and older Location: Rohnert Park Cancer Center, Rohnert Park, Calif. and more (North America)

NCT03180268: Observation or Radiation Therapy in Treating Patients with Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery; Phase III

Age: 18 years and older Location: Rohnert Park Cancer Center, Rohnert Park, Calif. and more (international)

NCT02523014: Vismodegib, FAK Inhibitor GSK2256098, Capivasertib, and Abemaciclib in Treating Patients with Progressive Meningiomas; Phase II

Age: 18 years and older Phases: Phase 2 Location: Kaiser Permanente, Santa Rosa, Calif.; Sutter Pacific Medical Foundation, Santa Rosa, Calif. and more (national)

NCT03550391: Stereotactic Radiosurgery Compared with Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5-15 Brain Metastases; Phase III

Age: 18 years and older Location: Rohnert Park Cancer Center, Rohnert Park, Calif. and more (North America)

NCT03328026: Combination Study of SV-BR-1-GM in Combination with INCMGA00012 and Epacadostat; Phase I, Phase II

Age: 18 years and older Location: Providence Medical Foundation, Santa Rosa, Calif. and more (national)

NCT01901094: Comparison of Axillary Lymph Node Dissection with Axillary Radiation for Patients with Node-Positive Breast Cancer Treated with Chemotherapy; Phase III

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Providence Medical Foundation, Santa Rosa, Calif.; Rohnert Park Cancer Center, Rohnert Park, Calif. and more (North America)

NCT02445391: Platinum Based Chemotherapy or Capecitabine in Treating Patients with Residual Triple-Negative Basal-Like Breast Cancer Following Neoadjuvant Chemotherapy; Phase III

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Sutter Pacific Medical Foundation, Santa Rosa, Calif.; Rohnert Park Cancer Center, Rohnert Park, Calif. and more (international)

NCT04457596: T-DM1 and Tucatinib Compared with T-DM1 Alone in Preventing Relapses in People with High Risk HER2Positive Breast Cancer, the CompassHER2 RD Trial; Phase III

Age: 18 years and older Location: Sutter Pacific Medical Foundation, Santa Rosa, Calif. and more (national)

NCT04266249: CompassHER2pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy; Phase II

Age: 18 years and older Location: Sutter Pacific Medical Foundation, Santa Rosa, Calif. and more (national)

NCT02488967: Doxorubicin Hydrochloride and Cyclophosphamide Followed by Paclitaxel with or without Carboplatin in Treating Patients with Triple-Negative Breast Cancer; Phase III

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Sutter Pacific Medical Foundation, Santa Rosa, Calif. and more (North America)

NCT04961996: A Study Evaluating the E cacy and Safety of Adjuvant Giredestrant Compared with Physician’s Choice of Adjuvant Endocrine Monotherapy in Participants with Estrogen Receptor-Positive, HER2-Negative Early Breast Cancer (lidERA Breast Cancer); Phase III

Age: 18 years and older Location: Providence Medical Foundation, Santa Rosa, Calif. and more (international)

NCT03199885: Testing the Drug Atezolizumab or Placebo with Usual Therapy in First-Line HER2-Positive Metastatic Breast Cancer; Phase III

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif. and more (North America)

NCT03488693: Regional Radiotherapy in Biomarker LowRisk Node Positive and T3N0 Breast Cancer; Phase III

Age: 35 years and older Location: Rohnert Park Cancer Center, Rohnert Park, Calif. and more (North America)

NCT03418961: S1501 Carvedilol in Preventing Cardiac Toxicity in Patients with Metastatic HER-2Positive Breast Cancer; Phase III

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Rohnert Park Cancer Center, Rohnert Park, Calif. and more (international)

NCT04869943: E cacy Evaluation of Enobosarm Monotherapy in Treatment of AR+/ER+/HER2- Metastatic Breast Cancer; Phase III

Age: 18 years to 100 years Location: Providence Medical Foundation, Santa Rosa, Calif. and more (international)

NCT01872975: Standard or Comprehensive Radiation Therapy in Treating Patients with EarlyStage Breast Cancer Previously Treated with Chemotherapy and Surgery

Age: 18 years and older Location: Rohnert Park Cancer Center, Rohnert Park, Calif. and more (international)

Cervical cancer

NCT01649089: Studying the Physical Function and Quality of Life Before and After Surgery in Patients with Stage I Cervical Cancer

Age: 18 years and older Location: Sutter Pacific Medical Foundation, Santa Rosa, Calif. and more (international)

NCT01101451: Radiation Therapy with or without Chemotherapy in Patients with Stage I-IIA Cervical Cancer Who Previously Underwent Surgery; Phase III

Age: 18 years and older Location: Sutter Pacific Medical Foundation, Santa Rosa, Calif. and more (international)

NCT02466971: Testing the Addition of a New Anti-Cancer Drug, Triapine, to the Usual Chemotherapy Treatment (Cisplatin) During Radiation Therapy for Advanced-stage Cervical and Vaginal Cancers; Phase III

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Rohnert Park Cancer Center, Rohnert Park, Calif. and more (national)

NCT04094688: Vitamin D3 with Chemotherapy and Bevacizumab in Treating Patients with Advanced or Metastatic Colorectal Cancer; Phase III

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Rohnert Park Cancer Center, Rohnert Park, Calif. and more (national)

NCT02912559: Combination Chemotherapy with or without Atezolizumab in Treating Patients with Stage III Colon Cancer and Deficient DNA Mismatch Repair; Phase III

Age: 12 years and older Location: Sutter Pacific Medical Foundation, Santa Rosa, Calif. and more (national)

NCT03365882: S1613, Trastuzumab and Pertuzumab or Cetuximab and Irinotecan Hydrochloride in Treating Patients with Locally Advanced or Metastatic HER2/Neu Amplified Colorectal Cancer That Cannot Be Removed by Surgery; Phase II

Age: 18 years and older Location: Sutter Pacific Medical Foundation, Santa Rosa, Calif. and more (national)

NCT01349881: S0820, Adenoma and Second Primary Prevention Trial of Colorectal Neoplasms; Phase III

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Sutter Pacific Medical Foundation, Santa Rosa, Calif. and more (national)

HPV

NCT03811015: Testing Immunotherapy Versus Observation in Patients with HPV Throat Cancer; Phase II, Phase III

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Rohnert Park Cancer Center, Rohnert Park, Calif. and more (national)

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NCT03793179: Testing the Timing of Pembrolizumab Alone or with Chemotherapy as First Line Treatment and Maintenance in Non-small Cell Lung Cancer; Phase III

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Sutter Pacific Medical Foundation, Santa Rosa, Calif., Rohnert Park Cancer Center, Rohnert Park, Calif. and more (North America)

NCT02201992: Crizotinib in Treating Patients with Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Removed by Surgery and ALK Fusion Mutations (An ALCHEMIST Treatment Trial); Phase III

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Sutter Pacific Medical Foundation, Santa Rosa, Calif., Rohnert Park Cancer Center, Rohnert Park, Calif. and more (national)

NCT02194738: Genetic Testing in Screening Patients with Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The ALCHEMIST Screening Trial)

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Sutter Pacific Medical Foundation, Santa Rosa, Calif., Rohnert Park Cancer Center, Rohnert Park, Calif. and more (national)

NCT03851445: Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer; Phase II, Phase III

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Rohnert Park Cancer Center, Rohnert Park, Calif. and more (national)

NCT03845296: Rucaparib in Treating Patients with Genomic LOH High and/or Deleterious BRCA1/2 Mutation Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial); Phase II

Age: Child, Adult, Older Adult Location: Kaiser Permanente, Santa Rosa, Calif.; Sutter Pacific Medical Foundation, Santa Rosa, Calif.; Rohnert Park Cancer Center, Rohnert Park, Calif. and more (national)

NCT04334941: Testing Maintenance Therapy for Small Cell Lung Cancer in Patients with SLFN11 Positive Biomarker; Phase II

Age: 18 years and older Location: Providence Medical Foundation, Santa Rosa, Calif. and more (national)

NCT03447769: Brief Title: Study of E cacy and Safety of Canakinumab as Adjuvant Therapy in Adult Subjects with Stages AJCC/UICC v. 8 II-IIIA and IIIB (T>5cm N2) Completely Resected Non-small Cell Lung Cancer Acronym: CANOPY-A; Phase III

Age: 18 years and older Location: Providence Medical Foundation, Santa Rosa, Calif. and more (international)

NCT04092283: Testing the Addition of an Antibody to Standard Chemoradiation Followed by the Antibody for One Year to Standard Chemoradiation Followed by One Year of the Antibody in Patients with Unresectable Stage III NonSmall Cell Lung Cancer; Phase III

Age: 18 years and older Location: Sutter Pacific Medical Foundation, Santa Rosa, Calif. and more (national)

NCT04181060: Osimertinib with or without Bevacizumab as Initial Treatment for Patients with EGFR-Mutant Lung Cancer; Phase III

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif. and more (national)

NCT04625647: Testing the Use of Targeted Treatment (AMG 510) for KRAS G12C Mutated Advanced Non-squamous Nonsmall Cell Lung Cancer (A LungMAP Treatment Trial); Phase II

Age: 18 years and older Location: Sutter Pacific Medical Foundation, Santa Rosa, Calif. and more (national)

NCT04380636: Study of Pembrolizumab with Concurrent Chemoradiation Therapy Followed by Pembrolizumab with or without Olaparib in Stage III Non-Small Cell Lung Cancer (NSCLC) (MK7339-012/KEYLYNK-012); Phase III

Age: 18 years and older Location: Providence Medical Foundation, Santa Rosa, Calif. and more (international)

NCT04262856: Study to Evaluate Monotherapy and Combination Immunotherapies in Participants with PD-L1 Positive Non-small Cell Lung Cancer; Phase II

Age: 18 years and older Location: Providence Medical Foundation, Santa Rosa, Calif. and more (international)

Nasopharyngeal cancer

NCT02135042: Individualized Treatment in Treating Patients with Stage II-IVB Nasopharyngeal Cancer Based on EBV DNA; Phase II, Phase III

Age: 18 years and older Location: Rohnert Park Cancer Center, Rohnert Park, Calif. and more (international)

Other cancers

NCT04803305: Study to Compare the E ects of Repeated Doses of an Investigational New Drug and a Placebo on Appetite in Advanced Cancer and Anorexia; Phase I

Age: 18 years and older Location: Providence Medical Foundation, Santa Rosa, Calif. and more (North America)

NCT03761914: Galinpepimut-S in Combination with Pembrolizumab in Patients with Selected Advanced Cancers; Phase I, Phase II

Age: 18 years and older Location: St. Joseph Heritage Healthcare, Santa Rosa, Calif. and more (national)

Ovarian / Endometrial / Uterine cancers

NCT04251052: A Study to Compare Two Surgical Procedures in Women with BRCA1 Mutations to Assess Reduced Risk of Ovarian Cancer

Age: 35 years to 50 years Location: Kaiser Permanente, Santa Rosa, Calif.; Rohnert Park Cancer Center, Rohnert Park, Calif. and more (national)

NCT02502266: Testing the Combination of Cediranib and Olaparib in Comparison to Each Drug Alone or Other Chemotherapy in Recurrent Platinum-Resistant Ovarian Cancer; Phase II, Phase III

Age: 18 years and older Location: Sutter Pacific Medical Foundation, Santa Rosa, Calif. and more (national)

NCT04095364: Letrozole with or without Paclitaxel and Carboplatin in Treating Patients with Stage II-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer; Phase III

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Providence Medical Foundation, Santa Rosa, Calif. and more (international)

NCT04739800: Comparison of Standard of Care Treatment with a Triplet Combination of Targeted Immunotherapeutic Agents for Ovarian, Endometrial and Fallopian Tube Cancers; Phase II

Age: 18 years and older Location: Sutter Pacific Medical Foundation, Santa Rosa, Calif. and more (national)

NCT03660826: Testing the Combination of Olaparib and Durvalumab, Cediranib and Durvalumab, Olaparib and Capivasertib, and Cediranib Alone in Recurrent or Refractory Endometrial Cancer Following the Earlier Phase of the Study That Tested Olaparib and Cediranib in Comparison to Cediranib Alone, and Olaparib Alone; Phase II

Age: 18 years and older Location: Providence Medical Foundation, Santa Rosa, Calif.; Sutter Pacific Medical Foundation, Santa Rosa, Calif.; Providence Santa Rosa Memorial Hospital, Santa Rosa, Calif. and more (national)

Pancreatic cancer

NCT02595424: Cisplatin, Carboplatin and Etoposide or Temozolomide and Capecitabine in Treating Patients with Neuroendocrine Carcinoma of the Gastrointestinal Tract or Pancreas That Is Metastatic or Cannot Be Removed by Surgery; Phase II

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Sutter Pacific Medical Foundation, Santa Rosa, Calif. and more (national)

NCT04548752: Testing the Addition of Pembrolizumab, an Immunotherapy Cancer Drug to Olaparib Alone as Therapy for Patients with Pancreatic Cancer That Has Spread with Inherited BRCA Mutations; Phase II

Age: 18 years and older Location: Sutter Pacific Medical Foundation, Santa Rosa, Calif. and more (national)

NCT03375320: Testing Cabozantinib in Patients with Advanced Pancreatic Neuroendocrine and Carcinoid Tumors; Phase III

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif. and more (national)

Prostate cancer

NCT03678025: Standard Systemic Therapy with or without Definitive Treatment in Treating Participants with Metastatic Prostate Cancer; Phase III

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Rohnert Park Cancer Center, Rohnert Park, Calif. and more (North America)

NCT03419234: Abiraterone Acetate and Antiandrogen Therapy with or without Cabazitaxel and Prednisone in Treating Patients with Metastatic, CastrationResistant Prostate Cancer Previously Treated with Docetaxel; Phase II

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Sutter Pacific Medical Foundation, Santa Rosa, Calif. and more (national)

NCT03070886: Antiandrogen Therapy and Radiation Therapy with or without Docetaxel in Treating Patients with Prostate Cancer That Has Been Removed by Surgery; Phase II, Phase III

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Rohnert Park Cancer Center, Rohnert Park, Calif. and more (North America)

NCT04455750: A Clinical Study Evaluating the Benefit of Adding Rucaparib to Enzalutamide for Men with Metastatic Prostate Cancer That Has Become Resistant to TestosteroneDeprivation Therapy; Phase III

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif. and more (national)

NCT02975934: A Study of Rucaparib Versus Physician’s Choice of Therapy in Patients with Metastatic Castration-resistant Prostate Cancer and Homologous Recombination Gene Deficiency; Phase III

Age: 18 years and older Location: Providence Medical Foundation, Santa Rosa, Calif. and more (international)

NCT03367702: Stereotactic Body Radiation Therapy or Intensity-Modulated Radiation Therapy in Treating Patients with Stage IIA-B Prostate Cancer; Phase III

Age: 18 years and older Location: Rohnert Park Cancer Center, Rohnert Park, Calif. and more (international)

Rare tumors / solid tumors

NCT02834013: Nivolumab and Ipilimumab in Treating Patients with Rare Tumors; Phase II

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Providence Medical Foundation, Santa Rosa, Calif.; Sutter Pacific Medical Foundation, Santa Rosa, Calif. and more (international)

NCT02465060: Targeted Therapy Directed by Genetic Testing in Treating Patients with Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial); Phase II

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Sutter Pacific Medical Foundation, Santa Rosa, Calif., Rohnert Park Cancer Center, Rohnert Park, Calif. and more (national)

NCT03887702: Prophylactic Antiviral Therapy in Patients with Current or Past Hepatitis B Virus Infection Receiving Anti-Cancer Therapy for Solid Tumors; Phase III

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Rohnert Park Cancer Center, Rohnert Park, Calif. and more (international)

NCT03893955: A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary E cacy of ABBV-927 with ABBV-368, Budigalimab (ABBV181) and/or Chemotherapy in Participants with Locally Advanced or Metastatic Solid Tumors; Phase I

Age: 18 years and older Location: St Jude Hospital dba Providence Medical Foundation, Santa Rosa, Calif. and more (international)

NCT04032704: A Study of Ladiratuzumab Vedotin in Advanced Solid Tumors; Phase II

Age: 18 years and older Location: Providence Medical Foundation, Santa Rosa, Calif. and more (international)

NCT03251378: A Multi-Center, Open-Label Study of Fruquintinib in Solid Tumors, Colorectal, and Breast Cancer; Phase I

Age: 18 years and older Location: Providence Medical Foundation, Santa Rosa, Calif. and more (national)

NCT03093116: A Study of Repotrectinib (TPX-0005) in Patients with Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements; Phase I, Phase II

Age: 12 years and older Location: Providence Medical Foundation, Santa Rosa, Calif. and more (international)

Renal cancer

NCT04195750: A Study of Belzutifan (MK-6482) Versus Everolimus in Participants with Advanced Renal Cell Carcinoma (MK-6482-005); Phase III

Age: 18 years and older Location: Providence Medical Foundation, Santa Rosa, Calif. and more (international)

Skin cancers

NCT03698019: A Study to Compare the Administration of Pembrolizumab After Surgery Versus Administration Both Before and After Surgery for High-Risk Melanoma; Phase II

Age: 18 years and older Location: Kaiser Permanente, Santa Rosa, Calif.; Providence Medical Foundation, Santa Rosa, Calif.; Sutter Pacific Medical Foundation, Santa Rosa, Calif. and more (national)

NCT02339571: Trial of Nivolumab, Ipilimumab, and GMCSF in Patients with Advanced Melanoma; Phase II, Phase III

Age: 18 years and older Location: Sutter Pacific Medical Foundation, Santa Rosa, Calif. and more (national)

NCT03712605: Testing Pembrolizumab Versus Observation in Patients with Merkel Cell Carcinoma After Surgery, STAMP Study; Phase III

Age: 18 years and older Location: Sutter Pacific Medical Foundation, Santa Rosa, Calif. and more (national)

NCT03765918: Study of Pembrolizumab Given Prior to Surgery and in Combination with Radiotherapy Given Post-surgery for Advanced Head and Neck Squamous Cell Carcinoma (MK3475-689); Phase III

Age: 18 years and older Location: Providence Medical Foundation, Santa Rosa, Calif. and more (international)

CARDIAC

NCT04435626: Study to Evaluate the E cacy and Safety of Finerenone on Morbidity & Mortality in Participants with Heart Failure and Left Ventricular Ejection Fraction Greater or Equal to 40%; Phase III

Age: 40 years and older Location: NorthBay Clinical Research, Santa Rosa, Calif. and more (international)

CHRONIC PAIN

NCT04096391: Post-market, Randomized, Controlled, Prospective Study Evaluating Intrathecal Pain Medication (IT) Versus Conventional Medical Management (CMM) in the Noncancer, Refractory, Chronic Pain Population

Age: 22 years and older Location: Evolve Restorative Center, Santa Rosa, Calif.

NCT04944459: Meditation Utilizing Signals from Electroencephalography in Chronic Pain (MUSE-PAIN) Study

Age: 18 years and older Location: Pacific Research Institute, LLC, Santa Rosa, Calif. and more (national)

NCT04676022: SCS as an Option for Chronic Low Back and/ or Leg Pain Instead of Surgery

Age: 22 years and older Location: Summit Pain Alliance, Santa Rosa, Calif. and more (national)

EYE HEALTH

NCT04734210: A Study to See How Well an Eye Drop, SURF-200 (0.02% and 0.04% Betamethasone Sodium Phosphate), Works, What Side E ects There Are, and to Compare it with Vehicle (Placebo) in Subjects Diagnosed with Dry Eye Disease and Experiencing an Episodic Flare-Up; Phase II

Age: 18 years and older Location: North Bay Eye Associates, Petaluma, Calif. and more (national)

NCT04810962: E cacy and Safety of APP13007 for Treatment of Ocular Inflammation and Pain After Cataract Surgery Including a Corneal Endothelial Cell Substudy; Phase III

Age: 18 years and older Location: North Bay Eye Associates, Petaluma, Calif. and more (national)

NCT03697811: DE-117 Spectrum 5 Study of Primary Openangle Glaucoma and Ocular Hypertension; Phase III

Age: 18 years and older Location: North Bay Eye Associates, Petaluma, Calif. and more (national)

NCT04599972: An Evaluation of the E cacy and Safety of CSF-1 in the Temporary Correction of Presbyopia (NEAR-2); Phase III

Age: 45 years to 64 years Location: Orasis Investigative Site, Petaluma, Calif. and more (national)

NCT04676737: TTHX1114(NM141) in Combination with DWEK/ DSO for Patients with Fuchs’ Endothelial Dystrophy; Phase II

Age: 18 years and older Location: North Bay Eye Associates, Petaluma, Calif. and more (national)

NCT04647214: ARGOS - Assess the E ectiveness and Safety of Bimatoprost Intracameral Implant (DURYSTA); Phase IV

Age: 18 years and older Location: North Bay Eye Associates, Petaluma, Calif. and more (national)

NCT05049070: Evaluate the Reliability, Validity and Safety of Subjective Mobile Refraction

Age: 18 to 39 years Location: North Bay Eye Associates, Petaluma, Calif. and more (national)

NCT04899063: Evaluate the Safety and E ectiveness of the ELIOS System to Reduce Intraocular Pressure in Patients with Primary Open-Angle Glaucoma Undergoing Cataract Surgery

Age: 45 years and older Location: North Bay Eye Associates, Petaluma, Calif. and more (national)

NCT04899518: Evaluate the Safety and E cacy of Two Concentrations (0.4% and 1%) of ALY688 Ophthalmic Solution in Subjects with Dry Eye Disease (OASIS-1); Phase II, Phase III

Age: 18 years and older Location: North Bay Eye Associates, Petaluma, Calif. and more (national)

NCT04599972: Evaluate the E cacy and Safety of CSF-1 in the Temporary Correction of Presbyopia (the NEAR-2 Study: Near Eye-vision Acuity Restoration)

Age: 45 to 64 years Location: North Bay Eye Associates, Petaluma, Calif. and more (national)

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NCT04630808: Evaluate the Safety and E cacy of NCX 470 vs. Latanoprost 0.005% in Subjects with Open-Angle Glaucoma or Ocular Hypertension (Mont Blanc); Phase III

Age: 18 to 84 years Location: North Bay Eye Associates, Petaluma, Calif. and more (national)

MENTAL HEALTH

NCT01327690: Mental Health and Post-Traumatic Stress Disorders in Veterans and Families After Group Therapies; Phase I

Age: 18 years to 80 years Location: Soul Medicine Institute, Santa Rosa, Calif.

NCT00737399: Anxiety and Depression Levels in Cancer Patients After Self-Application of EFT (Emotional Freedom Techniques); Phase I

Age: 18 years to 89 years Location: Soul Medicine Institute, Santa Rosa, Calif.

PSORIASIS

NCT04036435: Long-Term Study That Measures the Safety and E cacy of Deucravacitinib (BMS-986165) in Participants with Psoriasis; Phase III

Age: 18 years and older Location: NorthBay Clinical Research, Santa Rosa, Calif.; Synexus, Santa Rosa, Calif. and more (international)