Response to Stephen Sovey
Hello Stephen, great discussion post. Huntington’s disease is a neurodegenerative disease caused by abnormal huntingtin protein.
This disease is also a result of a genetic defect of chromosome 4. The normal huntingtin protein comprises multiple repeats of a sequence of three DNA bases, cytosine-adenine-guanine (CAG), that encodes the amino acid glutamine.
Normally,CAG is repeated 10 to 28 times, while abnormal CAG present in people with Huntington’s disease is repeated 36 to 120 times (Mattis & Svendsen, 2017). When over 36 repeats occur in the protein, an abnormal protein is released.
The resulting mutant form of a protein is more proneto aggregation and responsible for the prevalent neurodegeneration that occurs in Huntington’s disease (Caron et al., 2018).
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