1/30/13 CURRICULUM VITAE WILLIAM FRANK REGINE, M.D. ____________________________________________________________________________________ OFFICE ADDRESS: UNIVERSITY OF MARYLAND MEDICAL SYSTEM Department of Radiation Oncology 22 S. Greene Street, Room GGK0101 Baltimore, MD 21201 Telephone: (410) 328-2326 E-mail: wregine@umm.edu ACADEMIC DEGREES: B.S.
1983
State University of New York at Albany, Albany, New York (Chemistry, Summa Cum Laude)
M.D.
1987
State University of New York Health and Science Center at Syracuse, Syracuse, New York
William F. Regine, M.D. Curriculum Vitae - Page 2
PROFESSIONAL APPOINTMENTS: 1987-88
Transitional Intern, St. Joseph's Hospital, Syracuse, New York
1988-91
Resident, Department of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania
1991.92.1
Fellow, Gastrointestinal - Head and Neck Malignancies, Departments of Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania and University of FL, Gainesville, FL
1992-94
Assistant Member, Department of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee
1992.94.1
Assistant Professor, Section of Radiation Oncology, University of Tennessee, Memphis, Tennessee
1994
Assistant Professor and Acting Clinical Chief, Section of Radiation Oncology, University of Tennessee, Memphis, Tennessee
1994-1997
Assistant Professor, Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky
1997-2002
Associate Professor, with Tenure, Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky
William F. Regine, M.D. Curriculum Vitae - Page 3
1997-2002
Associate Professor, Joint Appointment, Department of Surgery, Division of Neurosurgery, University of Kentucky, Lexington, Kentucky
1998-2000
Associate Director for Clinical Research, Markey Cancer Center, University of Kentucky, Lexington, Kentucky
1998–2002
Co-Director, University of Kentucky Gamma Knife Radiosurgery Program
2000-2002
Vice-Chairman, Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky
2002
Co-Director, Department of Radiation Medicine Residency Program, University of Kentucky, Lexington, Kentucky
2002
Professor, with Tenure, Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky
2002
Professor, Joint Appointment, Department of Surgery, Division of Neurosurgery, University of Kentucky, Lexington, Kentucky
2002–present
Professor and Chairman, Department of Radiation Oncology
William F. Regine, M.D. Curriculum Vitae - Page 4
University of Maryland School of Medicine, Baltimore, Maryland HONORS: 1979
New York State Regent's College Scholarship
1981
State University of New York at Albany's Honor Society: Signum Laudis
1982
Phi Beta Kappa
1984-86
Honors - Epidemiology, Pediatrics, Anesthesiology, Hematology-Oncology, Otolaryngology, Radiation Oncology, Surgery
1991
Chief Resident, Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, PA
199 1
American Cancer Society Clinical Oncology Fellowship Award
1995
American Society for Therapeutic Radiology and Oncology - European Society for Therapeutic Radiology and Oncology Exchange Program Travel Grant Award
2002.4.1
Selected for listing among “Best Doctors in America�
2006
Elected President of the Simon Kramer Society
William F. Regine, M.D. Curriculum Vitae - Page 5
2007
National Departmental Rank of “Top 10” in NIH Funding (6 th – 2005)
CERTIFICATION/LICENSURE: Diplomat, National Board of Medical Examiners (1987) Medical Physician and Surgeon (Pennsylvania) Medical Physician and Surgeon (Tennessee) Medical Physician and Surgeon (Kentucky) Medical Physician and Surgeon (Maryland) Board Certified in Radiation Oncology (1992) LAB RESEARCH EXPERIENCE: 1982.83
Synthesized and studied steric hindrances within sulfonamide series. Supervised by William Closson, Ph.D., State University of New York at Albany
1991
Studied Murine bone marrow macrophage colony-forming unit response to radiation and hyperthermia. Supervised by Michael D. O'Hara, Ph.D., Department of Radiation Oncology, Thomas Jefferson University Hospital
PROFESSIONAL SOCIETY MEMBERSHIPS:
William F. Regine, M.D. Curriculum Vitae - Page 6
American Brain Tumor Association American College of Radiology American Medical Association American Radium Society American Society of Therapeutic Radiologists and Oncologists American Society of Clinical Oncology Baltimore City Medical Society Radiation Therapy Oncology Group Phi Beta Kappa Simon Kramer Society The Society of Head and Neck Surgeons The Society of Neuro-Oncology The Rare Cancer Network PUBLICATIONS: ORIGINAL PEER-REVIEWED ARTICLES 1.
Sagerman RH, Kotlove DJ, Regine WF, Chung CT, King GA, Dalal PS. Stage II Seminoma: Results of Postorchiectomy Irradiation. Radiology 172: 565-568, 1989.
2.
Regine WF, Ayyangar K, Komarnicky LT, Bhandare N, Mansfield CM. Computer-CT Planning of the Electron Boost in Definitive Breast Irradiation. Int J Radiat Oncol Biol Phys 20(1): 121-125, 1991.
William F. Regine, M.D. Curriculum Vitae - Page 7
3.
Regine WF, Kramer S. Pediatric Craniopharyngiomas: Long-Term Results of Combined Treatment with Surgery and Radiation. Int J Radiat Oncol Biol Phys 24(4): 611-617, 1992.
4.
Regine WF, Mohiuddin M. Impact of Adjuvant Therapy on Locally Advanced Adenocarcinoma of the Stomach. Int J Radiat Oncol Biol Phys 24(5): 921-927, 1992.
5.
Regine WF, Mohiuddin M, Kramer S. Long-Term Results of Pediatric and Adult Craniopharyngiomas Treated with Combined Surgery and Radiation. Radiotherapy Oncol 27: 13-21, 1993.
6.
Regine WF, Mendenhall WM, Parsons JT, Stringer SP, Cassisi NJ, Million RR. Radiotherapy for Adenoid Cystic Carcinoma of the Palate. Head & Neck 15: 241-244, 1993.
7.
Regine WF, Fontanesi J, Kumar P, Ayers D, Bowman LC, Pappo AS, Coffey DH, Avery L, Rao BN, Kun LE. Local Tumor Control in Rhabdomyosarcoma Following Low-Dose Irradiation:comparison of Group II and select Group III patients. Int J Radiat Oncol Biol Phys 31(3): 485-491, 1995.
8.
Kumar P, Mulhern RK, Regine WF, Rivera GK, Kun LE. A Prospective Neurocognitive Evaluation of Children Treated with Additional Chemotherapy and Craniospinal Irradiation Following Isolated Central Nervous System Relapse in Acute Lymphoblastic Leukemia. Int J Radiat Oncol Biol Phys 31(3): 561-566, 1995.
9.
Regine WF, Fontanesi J, Kumar P, Zeitzer K, Greenwald C, Bowman L, Shapiro DN, Rao BN, Kun LE. A Phase II Trial Evaluating Selective Use of Altered Radiation Dose and Fractionation in Patients with Unresectable Rhabdomyosarcoma. Int J Radiat Oncol Biol Phys 31(4): 799-805, 1995.
10.
O'Hara MD, Pollard M, Wheatley G, Regine WF, Mohiuddin M, Leeper D. Thermal Response and Hyperthermic Radiosensitization of SCID Mouse Bone Marrow CFU-C. Int J Radiat Oncol Biol Phys 31(4): 905-910, 1995.
11.
Mohiuddin M, Regine WF, Stevens J, Rosato F, Barbot D, Biermann W, Cantor R. Combined Intraoperative Radiation and Perioperative Chemotherapy for Unresectable Cancers of the Pancreas. J Clin Oncol 13: 2764-2768,1995.
William F. Regine, M.D. Curriculum Vitae - Page 8
12.
Mohiuddin M, Regine WF, Marks G. Prognostic Significance of Tumor Fixation in Rectal Cancer: Implications for Adjunctive Radiation Therapy. Cancer 78(4): 717-722, 1996.
13.
Robbins KT, Kumar P, Regine WF, Wong FSH, Weir III AB, Flick P, Kun LE, Palmer R, Murray T, Fontanesi J, Ferguson R, Thomas R, Hartsell W, Paig CU, Salazar G, Norfleet L, Hanchett CB, Harrington V, Niell B. Efficacy of Targeted Supradose Cisplatin and Concomitant Radiation Therapy for Advanced Head and Neck Cancer: The Memphis Experience. Int J Radiat Oncol Biol Phys 38(2): 263-271, 1997.
14. Regine WF, Valentino J, Sloan DA, Patel P, Mohiuddin M, Kenady DE. Efficacy of Postoperative Radiation Therapy for Recurrent Squamous Cell Carcinoma of the Head and Neck. Int J Radiat Oncol Biol Phys 39(2): 297-302, 1997. 15.
Young B, Regine WF, Sanders MF, Strottmann JM . Whole Brain Radiation Therapy for Treating Cerebral Metastasis May Not Be Necessary After Stereotactic Radiosurgery Performed with MagnetizationPrepared, Rapid-Acquisition Gradient Echo MRI with Triple-Dose Contrast. Radiosurgery 2: 72-77,1997.
16.
Mohiuddin M, Regine WF, Marks GJ, Marks JW. High-Dose Preoperative Radiation and the Challege of Sphincter-Preserving Surgery for Cancer of the Distal 2 cm of the Rectum. Int J Radiat Oncol Biol Phys 40(3): 569-574, 1998.
17.
Regine WF, Hodes JE, Patchell RY. Intracranial Germinoma: Treatment with Radiosurgery Alone. J Neuro-Onc 37(1): 75-77, 1998.
18.
Klyachkin ML, Schwartz RW, Cibull M, Munn RK, Regine WF, Kenady DE, McGrath PC, Sloan DA. Thyroid Lymphoma: Is There a Role for Surgery? The American Surgeon 64: 234-238,1998.
19.
Rudoltz MS, Regine WF, Langston JW, Sanford RA, Kovnar EH , Kun LE. Multiple Causes of Cerebrovascular Events in Children with Tumors of the Parasellar Region. J Neuro-Onc 37(3): 251-261, 1998.
20.
Meigooni AS, Valentino J, Regine WF. An Innovative Method for Optimization of Intraluminal Brachytherapy Dose Delivery for Tumors Involving the Carina. Journal of Brachytherapy International 14: 185-189, 1998.
21.
Mohiuddin M, Young BA, Regine WF. The Effects of Gamma Knife Radiosurgery on Tinnitus in Patients with Acoustic Neuromas. Journal of Radiosurgery 1(4): 265-270, 1998.
22.
Patchell RA, Tibbs PA, Regine WF, Dempsey RJ, Mohiuddin M, Kryscio RJ, Markesbery WR, Foon KA, Young B. Postoperative Radiotherapy in the Treatment of Single Metastases to the Brain: A Randomized Trial. JAMA 280(17): 1485-1489, 1998.
23.
Fujita M, Rudoltz MS, Canaday DJ, Patel P, Machtay M, Pittard MQ, Mohiuddin M, Regine WF. Second Malignant Neoplasia in Patients with T1 Glottic Cancer Treated with Radiation. Laryngoscope 108: 18531854, 1998.
William F. Regine, M.D. Curriculum Vitae - Page 9
24.
Canaday DJ, Regine WF, Mohiuddin M, Zollinger W, Machtay M, Lee J, Schultz D, Rudoltz MS. Significance of Pretreatment Hemoglobin Level in Patients with T1 Glottic Cancer. Radiation Oncology Investigations 7: 42-48, 1999.
25.
Regine WF, Valentino J, Sloan DA , Patel P, Pittard MQ, Kenady DE, Mohiuddin M. Postoperative Radiation Therapy for Primary vs. Recurrent Squamous Cell Carcinoma of the Head and Neck: Results of a Comparative Analysis. Head & Neck 21: 554-559, 1999.
26.
Mohiuddin M, Fujita M, Regine WF, Meigooni AS, Ibbott GS, Ahmed M. High Dose Spatially Fractionated Radiation (GRID): A New Paradigm in the Management of Advanced Cancers. Int J Radiat Oncol Biol Phys 45(3): 721-727, 1999.
27.
Sloan DA, Witzke DB, Plymale MA, Sloan PA, Regine WF, Valentino J, Schwartz RW, Kenady DE. A Multidisciplinary Workshop to Teach Head and Neck Oncology to Residents: Results of a Pilot Study. Journal of Cancer Education 14(4): 228-232, 1999.
28.
Valentino J, Weinstein L, Rosenblum R, Regine WF, Weinstein M. Radiation and Intra-Arterial Cisplatin. Effects on Arteries and Free Tissue Transfer. Arch Otolaryngol Head Neck Surg 126: 215- 219, 2000.
29.
Mohiuddin M, Regine WF, John WJ, Hagihara PF, McGrath PC, Kenady DE, Marks G. Preoperative Chemoradiation in Fixed Distal Rectal Cancer: Dose Time Factors for Pathological Complete Response. Int J Radiat Oncol Biol Phys 46(4): 883-888, 2000.
30.
Regine WF, John WJ, McGrath P, Strodel WE, Mohiuddin M. The Feasibility of Dose Escalation Using Concurrent Radiation and 5-Fluorouracil Therapy Following Pancreaticoduodenectomy for Pancreatic Carcinoma. J of Hepatobiliary Pancreat Surg 7: 53-57, 2000.
31.
Regine WF, Patchell RA, Strottman J, Sanders M, Meigooni AS, Young AB. Preliminary Report of a Phase I Study of Combined Fractionated Stereotactic Radiosurgery and Conventional External Beam Radiation Therapy for Unfavorable Gliomas. Int J Radiat Oncol Biol Phys 48(2): 421-426, 2000.
32.
Regine WF, Valentino J, John J, Storey G, Sloan D, Kenady D, Patel P, Pulmano C, Arnold S, Mohiuddin M. High-Dose Intra-Arterial Cisplatin and Concurrent Hyperfractionated Radiation Therapy in Patients with Locally Advanced Squamous Cell Carcinoma of the Head and Neck: Report of a Phase II Study. Head & Neck 22: 543549, 2000.
33.
Mohiuddin M, Hayne M, Regine WF, Hanna N, Hagihara P, McGrath P, Marks GM. Prognostic Significance of Postchemoradiation Stage Following Preoperative Chemotherapy and Radiation for Advanced/Recurrent Rectal Cancers. Int J Radiat Oncol Biol Phys 48(4): 1075-1080, 2000.
34.
Gamburg ES, Regine WF, Patchell RA, Strottmann JM, Mohiuddin M, Young AB. The Prognostic Significance of Midline Shift on Survival of Patients Presenting with Glioblastoma Multiforme. Int J Radiat Oncol Biol Phys 48(5): 1359-1362, 2000.
William F. Regine, M.D. Curriculum Vitae - Page 10
35.
Nicol B, Regine WF, Courtney C, Meigooni AS, Sanders M, Young B. Gamma Knife Radiosurgery Using 90 Gy for Trigeminal Neuralgia. J Neurosurg 93(S3): 152-154, 2000.
36.
Regine WF, Patchell RA, Strottman J, Meigooni AS, Sanders M, Young BA. Combined Stereotactic Split-Course Fractionated Gamma Knife Radiosurgery and Conventional Radiation Therapy for Unfavorable Gliomas: A Phase I Study. J Neurosurg 93(S3): 37-41, 2000.
37.
Regine WF, Valentino J, Arnold SM, Haydon RC, Sloan D, Kenady D, Strottman J, Pulmano C, Mohiuddin M. High-Dose Intra-Arterial Cisplatin Boost with Hyperfractionated Radiation Therapy for Advanced Squamous Cell Carcinoma of the Head and Neck. JCO 19(14): 3333-3339, 2001.
38.
Sanghavi SN, Miranpuri SS, Chappell R, Buatti JM, Sneed PK, Suh JH, Regine WF, Weltman E, King VJ, Goetsch SJ, Breneman JC, Sperduto PW, Scott C, Mabanta S, Mehta MP. Radiosurgery for Patients with Brain Metastases: A Multi-Institutional Analysis, Stratified by the RTOG Recursive Partitioning Analysis Methodology. Int J Radiat Oncol Biol Phys 51(2): 426-434, 2001.
39.
Regine WF, Scott C, Murray K, Curran W. Neurocognitive Outcome in Brain Metastasis Patients Treated with Accelerated Fractionation vs. Accelerated Hyperfractionated Radiotherapy: An Analysis From Radiation Therapy Oncology Group Study 91-04. Int J Radiat Oncol Biol Phys 51(3): 711-717, 2001.
40.
Jackson TR, Regine WF, Wilson D, Davis DG. Cerebellar Liponeurocytoma: Case Report, Review of the Literature and Therapeutic Implications. J Neurosurg 95(S4): 700-703, 2001.
41.
Regine WF, Huhn JL, Patchell RA, St. Clair WH, Strottmann J, Meigooni AS, Sanders M, Young AB. Risk of Symptomatic Brain Tumor Recurrence and Neurologic Deficit After Radiosurgery Alone in Patients With Newly Diagnosed Brain Metastases: Results and Implications. Int J Radiat Oncol Biol Phys 52(2): 333-338, 2002.
42.
Meigooni AS, Parker SA, Zheng J, Kalbaugh KJ, Regine WF, Mohiuddin M. Dosimetric Characteristics with Spatial Fractionation Using Electron GRID Therapy Med Dosimetry 27(1): 37-42 2002.
43.
Regine WF, Reid B, Patchell RA, St.Clair WH, Meigooni AS, Sims J, Sanders M, Young AB. Efficacy of 20 Gy Stereotactic Radiosurgery for < 2 cm Brain Metastases. Radiosurgery 4: 134-142, 2002.
44.
Regine WF, Valentino J, Arnold SM, Sloan D, Kenady D, Strottmann J, Mohiuddin M. A Phase II Study of Concomitant Hyperfracionated Radiation Therapy and Double Dose Intra-Arterial Cisplatin for Squamous Cell Carcinoma of the Head and Neck. Technology in Cancer Research and Treatment 1: 133-140, 2002.
45.
Sathishkumar S, Dey S, Meigooni AS, Regine WF, Kudrimoti M, Ahmed MM, Mohiuddin M. The Impact of TNF-Îą Induction on Therapeutic Efficacy Following High Dose Spatially Fractionated (GRID) Radiation. Technology in Cancer Research and Treatment 1: 141-147, 2002.
46.
Mohiuddin M, Chendil D, Dey S, Alcock RA, Regine WF, Mohiuddin M, Ahmed MM. Influence of p53 Status on Radiation and 5-Flourouracil Synergy in Pancreatic Cancer Cells. Anticancer Research 22: 825-830, 2002.
William F. Regine, M.D. Curriculum Vitae - Page 11
47.
Sneed PK, Suh JH, Goetsch SJ, Sanghavi SN, Chappell R, Buatti JM, Regine WF, Weltman E, King VJ, Breneman JC, Sperduto PW, Mehta MP. A Multi-Institutional Review of Radiosurgery Alone vs. Radiosurgery with Whole Brain Raditherapy as the Initial Management of Brain Metastases. Int J Radiat Oncol Biol Phys 53(3): 519-526, 2002.
48.
Valentino J, Spring PM, Shane M, Arnold SM Regine WF. Interval Pathologic Assessments In Patients Treated with Concurrent Hyperfractionated Radiation and Intraarterial Cisplatin (Hyperradplat). Head and Neck 24: 539544, 2002.
49.
Hahn SM, Bernard EJ, Regine WF, Mohiuddin M, Haller DG, Stevenson JP, Smith D, Pramanik, B, Tepper J, Delaney TF, Kiel KD, Morrison B, Deutsch P, Muschel RJ, McKenna WG. A Phase I Trial of the Farnesyltransferase Inhibitor L-778,123 and Radiotherapy for Locally Advanced Lung and Head and Neck Cancer. Clinical Cancer Research 8: 1065-1072, 2002.
50.
Mohiuddin M, Kudrimoti M, Regine WF, McGrath P, Hanna N, Meeker T, John W. Concurrent Infusional Gemcitabine and Radiation in the Treament of Advanced Unresectable GI Malignancy: A Phase I Study. Cancer Journal 8: 255-262, 2002.
51.
Mohiuddin M, Damodaran C, Swatee D, Alcock R, Regine WF, Mohiuddin M, Ahmed MM. Influence of p53 Status on Radiation and 5 - Flourouracil Synergy in Pancreatic Cancer Cells. Anticancer Research 22: 825-830, 2002.
52.
Patchell RA, Regine WF, Ashton P, Tibbs PA, Wilson D, Shappley D, Young BY. A phase I Trial of Continuously Infused Intratumoral Bleomycin for the Treatment of Recurrent Glioblastoma Multiforme. J NeuroOnc 60: 37-42, 2002.
53.
Dey S, Spring PM, Arnold S, Valentino J, Chendil D, Regine WF, Mohiuddin M, Ahmed MM. Low-Dose Fractionated Radiation Potentiates the Effects of Paclitaxel in Wild-type and Mutant p53 Head and Neck Tumor Cell Lines. Clin Ca Res 9: 1557-1565, April 2003.
54.
Anderson T, Regine WF, Kryscio R, Patchell RA. Neurologic complications of bladder cancer. A review of 359 cases. Cancer 97: 2267-72, 2003.
55.
Patchell RA, Regine WF. The Rational for Adjuvant Whole Brain Radiation Therapy with Radiosurgery in the Treatment of Single Brain Metastases. Tech Ca Res Treat 2(2): 111-115, 2003.
56.
Chin LS, Szerlip NJ, Regine WF. Stereotactic Radiosurgery for meningiomas. Neurosurg Focus 14(5): 1-6, 2003.
57.
Flannery TW, Suntharalingam M, Kwow Y, Koffman BH, Amin PP, Chin LS, Nicol B, Fowler, Young AB, Regine WF. Gamma Knife stereotactic radiosurgery for synchronous versus metachronous solitary brain metastases from non-small cell lung cancer. Lung Cancer, 42: 327-333, 2003.
58.
Arnold SM, Regine WF, Ahmed MM, Valentino J, Spring P, Kudrimoti M, Kenady D, Desimone P, Mohiuddin M. Low-dose Fractionated Radiation as a Chemopotentiator of Neoadjuvant Paclitaxel and Carboplatin for Locally Advanced Squamous Cell Carcinoma of the Head and Neck: Results of a New Treatment Paradigm. Int J Radiat Oncol Biol Phys 58(5): 1411-1417, 2004.
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59.
Shehata MK, Young AB, Reid B, Patchell RA, St Clair W, Sims J, Sanders M, Meigooni AS, Mohiuddin M, Regine WF. Stereotatic Radiosurgery (SRS) of 468 Brain Metastases â&#x2030;¤ 2 cm: Implications for SRS Dose and Whole Brain Radiation Therapy (WBRT). Int J Radiation Oncology Biol Phys 59(1): 87-93, 2004.
60.
Regine WF, Schmitt FA, Scott CB, Dearth C, Patchell RA, Nichols, RC, Gore EM, Franklin RL, Suh JH, Mehta MP. Feasibility of Neurocognitive Outcome Evaluations in Patients with Brain Metastases in a Multi-Institutional Cooperative Group Setting: Results of Radiation Therapy Oncology Group Trial BR-0018. Int J Radiation Oncology Biol Phys 58(5): 1346-1352, 2004.
61.
Cheuk AV, Chin LS, Petit JH, Herman JM, Fang HB, Regine WF. Imaging Correlates of Gamma Knife Outcome in Trigeminal Neuraliga. Int. J Radiation Oncology Biol. Phys 60(2): 537-541, 2004.
62.
Regine WF, Rogozinska A, Kryscio RJ, Tibbs PA, Young AB, Patchell RA. Recursive Partitioning Analysis Classifications I And II: Applicability Evaluated In A Randomized Trial For Resected Single Brain Metastases. Am J Clin Onc 27(5): 505-509, 2004.
63.
Martin NE, Brunner TB, Kiel KD, DeLaney TF, Regine WF, Mohiuddin M, Rosato EF, Haller DG, Stevenson JP, Smith D, Pramanik B, Tepper J, Tanaka WK, Morrison B, Deutsch P, Gupta AK, Muschel RJ, McKenna WG, Bernhard EJ, Hahn SM. A Phase I Trial of the Dual Farnesyltransferase and Geranylgeranyltransferase Inhibitor L-778,123 and Radiotherapy for Locally Advanced Pancreatic Cancer. Clinical Cancer Research, 10: 547- 554, 2004.
64.
DiBiase SJ, Kwok Y, Yavino S, Arena C, Naqvi S, Temple R, Regine WF, Amin P, Guo C, Chin LS. Factors Predicting Local Tumor Control After Gamma Knife Stereotactic Radiosurgery for Benign Intracranial Meningiomas. Int J Radiation Oncology Biol Phys 60(5): 1515-1519, 2004.
65.
Patchell R, Tibbs P, Regine WF, Payne R, Saris S, Kryscio R, Mohiuddin M, Young B. A randomized Trial of Direct Decompressive Surgical Resection in the Treatment of Spinal Cord Compression caused by metastatic cancer. The Lancet 366: 643-648, 2005.
66.
Gaugler J, Hanna N, Linder J, Given CW, Tolbert V, Kataria R, Regine WF. Cancer Caregiving and Subjective Stress: A Multi-Site Multi-Dimensional Analysis. Psycho-Oncology 14: 771-785, 2005.
67.
Spring P, Valentino J, Arnold S, Sloan D, Kenady D, Kudrimoti M, Haydon RC, Lee C, Mohiuddin M, Regine WF. Long-Term Results of Hyperfractionated Radiation and High-Dose Intraarterial Cisplatin for Unresectable Oropharyngeal Carcinoma: Cancer, 104(8): 1765-1771, 2005.
68.
Ma L, Kwok Y, Regine WF. Concomitant GRID Boost for Gamma Knife Radiosurgery: Med Phys 32(11): 3419-3423, 2005.
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69.
Ma L, Kwok Y, Chin LS, Yu C, Regine WF. Comparative analyses of linac and Gamma Knife Radiosurgery for Trigeminal Neuralgia reatments: Phys. Med Biol. 50: 5217-5227, 2005.
70.
Ha Jonathan, Zhang G, Naqvi SA, Regine WF, Yu CX. Feasibility of delivering grid therapy using a multileaf collimator: Med. Phys. 33(1): 76-82, 2006.
71.
Thomas KC, Nosyk B, Fisher CG, Dvorak Marcel, Patchell RA, Regine WF, Loblaw A, Bansback N, Guh D, Sun Huiying, Anis A. Cost-Effectiveness of Surgery Plus Radiotherapy versus Radiotherapy Alone for Metastatic Epidural Spinal Cord Compression. Int. Journal Radiation Oncology Biol. Phys. 66(4): 1212-1218, 2006.
72.
Huhn JL, Regine WF, Valentino J, Meigooni, AS, Kudrimoti M, Mohiuddin M. Spatially Fractionated GRID Radiation Treatment of Advanced Neck Disease Associated with Head and Neck Cancer. TCRT, 5(6): 607-610, December, 2006.
73.
Regine WF, Hanna N, Ahmed M, Garofalo MC, DeSimone P, Arnold S, Mohiuddin M. Low-dose Radiation Therapy as a Chemopotentiator of Gemcitabine in Tumors of the Pancreas/small bowel – A Phase I Study Exploring a New Treatment Paradigm. Int. Journal Radiation Oncology Biol. Phys. 68 (1): 172-177, 2007.
74.
D’Souza WD, Nazareth DP, Zhang B, DeYoung C, Suntharalingam M, Kwok Y, Yu Cx, Regine WF . The Use of Gated and 4D CT Imaging in Planning for Stereotactic Body Radition Therapy. Medical Dosimetry 32 (2): 92-101, 2007.
75.
Gaugler JE, Linder J, Given CW, Kataria R, Tucker G, Regine WF. Work, Gender and Stress in Family Cancer Cargiving. (In Press) Supportive Care in Cancer.
76.
Gaugler JE, Linder J, Given CW, Kataria R, Tucker G, Regine WF. The Proliferation of Primary Cancer Caregiving Stress to Secondary Stress. Cancer Nursing 31 (2) March/April 2008.
77.
Balcer-Kubiczek EK, Attarpourl M, Wang Jiang Z, Regine WF. The Effect of Docetaxel (Taxotere®) on Human Gastric Cancer Cancer Cells Exhibiting Low-dose Radiation Hypersensitivity. Clinical Med Oncology (accepted, December 2007).
William F. Regine, M.D. Curriculum Vitae - Page 14
INVITED SUBMISSIONS/LETTERS 1.
Regine WF, Ayyangar K, Komarnicky LT, Bhandare N, Mansfield CM. To Boost, Why and How. Int J Radiat Oncol Biol Phys 20(1): 179, 1991. [Letter]
65.
Mohiuddin M, Regine WF, Rosato F, Barbot D, Schuricht A, Biermann W, Cantor R. A Comparison of Intraoperative Radiation Therapy (IORT) and I-125 Implantation for Cancer of the Pancreas. Proceedings of the 4th International Symposium on Intraoperative Radiation Therapy: 315-323, 1994.
66.
Regine WF, Kun LE. Retrospective Results Need Prospective Confirmation. Int J Radiat Oncol Biol Phys 31(3): 681, 1995. [Letter]
67.
Regine WF, Kramer CK. To Boost or Not to Boost? . . . Itâ&#x20AC;&#x2122;s Not the Only Question! Int J Radiat Oncol Biol Phys 32(1):273 1995. [Letter]
68.
Regine WF, Mohiuddin M. Extrahepatic Biliary Duct Carcinoma: the Continuing Evolution of Multidisciplinary Management. Int J Radiat Oncol Biol Phys 34(4): 963-964, 1996.
69.
Regine WF, Mohiuddin M. Does Neck Stage Predict Local Control After Irradiation for Head and Neck Cancer Oncology 10(3):384-386, 1996.
70.
Regine WF, John WJ, Mohiuddin M. Current and Emerging Treatments for Pancreatic Cancer. Drugs & Aging 11(4): 285-295, 1997.
71.
Regine WF, Abrams RA. Adjuvant Therapy for Pancreatic Cancer: Back to the Future. Int J Radiat Oncol Biol 42(1): 59-63, 1998.
72.
Regine WF, John WJ, Mohiuddin M. Evolving Trends in the Combined Modality Therapy for Pancreatic Cancer. J of Hepatobiliary Pancreat Surg 5(3): 227-234, 1998.
73.
Regine WF, John WJ, Mohiuddin M. Adjuvant Therapy for Pancreatic Cancer: Current Status. Frontiers in Bioscience 3: 186-192, 1998.
74.
Patchell RA, Tibbs PA, Regine WF, Mohiuddin M, Kryscio RJ, Markesbery WR, Foon KA, Young B, Dempsey RJ. Postoperative Radiotherapy for Single Brain Metastases. JAMA 281(18): 1696, 1999. [Letter]
William F. Regine, M.D. Curriculum Vitae - Page 15
75.
Mohiuddin M, Regine WF, Mohiuddin Ma, Marks G. Defining the Multiple Modality Approach to the Treatment of Cancer of the Rectum. JIMA 31: 217-221, 1999.
76.
Regine WF, The Radiation Oncologistâ&#x20AC;&#x2122;s Perspective on Stereotactic Radiosurgery. TCRT 1(1): 43-49, 2002.
77.
Regine WF, Sperduto PW, Scott CB, Mehta, MP. What is the Appropriate Primary Endpoint for Clinical Trials for Patients With Brain Metastases. Int J Radiat Oncol Biol Phys 53(5):1394, 2002.
78.
Kenady DE, Arnold SM, Regine WF, Mentzer RM. Oral/Pharyngeal Squamous Carcinoma: Treatment Strategies. Journal of KMA 100: 318-324, 2002.
79.
Regine WF, Stereotactic Radiosurgery â&#x20AC;&#x201C; State of the Art. Tech Ca Res Treat 2(2):77-78, 2003.
80.
Willett CG, Safran H, Abrams RA, Regine WF, Rich TA, and the Gastrointestinal Committee of the RTOG. Clinical Research in Pancreatic Cancer: The Radiation Therapy Oncology Group Trials. Int J Radiat Oncol Biol Phys 56(4):31-37, 2003.
81.
Sloan AE, Arnold SM, St Clair WS, Regine WF. Brain Injury: Current Management and Investigations. Sem in Rad Onc 13(3):309-321, 2003.
82.
St. Clair WS, Arnold SM, Sloan AE, Regine WF. Spinal Cord and Peripheral Nerve Injury: Current Management and Investigations. Sem in Rad Onc 13(3):322-332, 2003.
83.
Garofalo M, Kwok Y, Regine WF. The Evolving Role of Postoperative Adjuvant Radiation Therapy for Pancreatic Cancer, Surg Oncol Clin N Am 13:589-604, 2004.
84.
Kwok Y, Patchell RA, Regine WF. Radiation Therapy Alone for Spinal Cord Compression: Time to Improve Upon a Relatively Ineffective Status Quo. J Clin Oncol 23:3308-3310, 2005.
85.
Patchell RA, Tibbs PA, Regine WF. Surgical Resection in Metastatic Spinal Cord Compression. Lancet 366 643648, 2005. [Letter]
86.
Kwok Y, DeYoung C, Garofalo MC, Dhople A, Regine WF. Radiation Oncology Emergencies. Hematology/Oncology Clinics of North America 20: 507-522, 2006.
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87.
Garofalo MC, Tan MT, Regine WF. On Statistical Reanalysis, the EORTC Trial is a Positive Trial for Adjuvant Chemoradiation in Pancreatic Cancer. Annals of Surgery 244: 332-333, 2006.
88.
Regine WF, Abrams RA. Adjuvant Therapy for Pancreatic Cancer: Current Status, Future Directions. Seminars in Oncology 33:(6) (S10-S13), 2006.
89.
Patchell RA, Regine WF, Loeffler JS, Sawaya R. Radiosurgery Plus Whole-Brain Radiation Therapy for Brain Metastasts. JAMA 296: (17) 2006. [Letter].
90.
Garofalo, MC, Abrams RA, Regine WF. Review of “Adjuvant Therapy for Pancreatic cancer – To Treat or Not to Treat?” Oncology 21: (6) May 2007. [Editorial]
28.
Garofalo MC, Nichols EM, Regine WF. Optimal Adjuvant Therapy for Resected Pancreatic Cancer: Chemotherapy or Chemoradiotherapy. Proceedings of Journal of the International Society of Gastrointestinal Oncology 1(5)182 - 186, September 2007. ABSTRACTS
1.
Regine WF, O'Hara MD, Mohiuddin M. Murine Bone Marrow Macrophage Colony Forming Units Response to Radiation +40-420C: Potential Implications for Combined Total Body Irradiation and Hyperthermia. Int J Radiat Oncol Biol Phys 21:202-203, 1991.
2.
Regine WF, Fontanesi J, Bowman L, Pappo A, Coffey D, Kun LE. Evaluation of Local Control with Selective Use of Low-Dose Irradiation Following Induction/Preoperative Chemotherapy for Locally Advanced Rhabdomyosarcoma. Int J Radiat Oncol Biol Phys 27: 131, 1993.
3.
O'Hara MD, Pollard M, Wheatley G, Regine WF, Mohiuddin M, Leeper D. Thermal Response and Hyperthermic Radiosensitization of SCID Mouse Bone Marrow CFU-C. Int J Radiat Oncol Biol Phys 27: 225, 1993.
4.
Regine WF, Greenwald C, Kumar P, Dombrowski J, Ballas D, Pappo A, Shapiro D, Bowman L, Rao B, Kun L. Use of Altered Radiation (RT) Dose and Fractionation in Patients with Unresectable Rhabdomyosarcoma (RMS) Based Upon Disease Status Following Induction Therapy: The St. Jude Experience. Proceedings of ASCO, J Clin Oncol 13: 419(#1433), 1994.
5.
Mohiuddin M, Regine WF, Ahmad N, Lingareddy V, Marks G. High Dose Preoperative Radiation and Sphincter Preservation Surgery for Cancer of the Distal 2 cm of the Rectum: The Ultimate Challenge. Int J Radiat Oncol Biol Phys 32(S1): 158, 1995.
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6.
Kumar P, Regine WF, Kun LE, Hanchett C, Palmer R, Fontanesi J, Paig CU, Harrington V, Flick PA, Ferguson R, Murry T, Wong F, Niell HB, Weir III A, Robbins KT. Efficacy of Supradose Intra-Arterial Targeted Cisplatin and Concurrent Radiation Therapy in the Treatment of Unresectable Stage III-IV Head and Neck Carcinoma. Int J Radiat Oncol Biol Phys 32(S1): 193,1995.
7.
Meigooni AS, Mohiuddin M, Ibbott GS, Regine WF, Ahmed VR, Kolarparthi VSR, Fruitwala S. Physical Dosimetry and Biological Basis of GRID Radiation Therapy. Medical Physics 23(6): 1105, June 1996.
8.
Regine WF, Valentino J, Sloan DA, Patel P, Mohiuddin M, Kenady D. Efficacy ofIrradiation for Recurrent Squamous Cell Carcinoma of the Head and Neck. Abstract Book of the 4th International Conference on Head and Neck Cancer: 152 (373), 1996.
9.
Mohiuddin M, Regine WF, Marks G. Long-Term (Ten Year) Results of High Dose Preoperative Radiation for Cancer of the Rectum. Int J Radiat Oncol Biol Phys 32(S1): 261, 1996.
10.
Regine WF, John WJ, Strodel WE, Mohiuddin M. Dose-Intensive Chemoradiation Following Pancreaticoduodenectomy for Pancreatic Carcinoma - A Phase I Study. Int J Radiat Oncol Biol Phys 32(S1): 299, 1996.
11.
Regine WF, Patel P, Valentino J, Sloan DA, Flett MQ, Mohiuddin M, Kenady DE. Results of Postoperative Irradiation for Squamous Cell Carcinoma of the Head and Neck: Is There a Difference Between Primary and Recurrent Disease? Int J Radiat Oncol Biol Phys 39(S2): 306(#2131), 1997.
12.
Canaday DJ, Regine WF, Mohiuddin M, Zollinger W, Machtay M, Lee J, Schultz D, Rosenthal DI, Rudoltz MS. Does Pretreatment Hemoglobin Level Affect Outcome in Patients with T1 Glottic Cancer. Int J Radiat Oncol Biol Phys 39(S2): 308(#2136), 1997.
13.
Mohiuddin M, Fujita M, Regine WF, Meigooni AS. Overcoming the Barrier of Radiation-Resistance in Advanced Cancer by Using High Dose Spatially Fractionated Radiation. Int J Radiat Oncol Biol Phys 39(S2): 329(#2178), 1997.
14.
Mohiuddin M, Regine WF, John W, Hagihara P, McGrath P, Kenady D. Dose/Time Factors in Preoperative Chemoradiation for Fixed Distal Rectal Cancer. Proceedings of ASCO, J Clin Oncol 17:298a(#1147), 1998.
15.
Regine WF, Valentino J, John W, Storey G, Sloan D, Kenady D. Toxicity and Response of High-Dose IntraArterial Cisplatin and Hyperfractionated Radiation Therapy in Patients with Locally Advanced Primary Squamous Cell Carcinoma of the Head and Neck. Combined Program of the American Society for Head and Neck Surgery and the Society of Head and Neck Surgeons, 46-47, 1998.
16.
Regine WF, Valentino J, John W, Storey G, Patel P, Sloan DA, Kenady DE, Pulmano C, Abner J, Mohiuddin M. Results of High-Dose Intra-Arterial Cisplatin and Hyperfractionated Radiation Therapy in Patients with High Volume Unfavorable Squamous Cell Carcinoma of the Head and Neck. Proceedings of ASCO, J Clin Oncol 17:394a(#1519), 1998.
17.
Meigooni AS, Parker S, Zheng M, Mohiuddin M, Regine WF. Dosimetric Characteristics in Electron GRID Therapy. AAPMannual meeting program, Medical Physics 25(7):A180(PO- 61), 1998.
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18.
Mohiuddin M, Regine WF, John W, Hagihara P, McGrath P, Kenady D, Marks GM. Dose Time Factors for Pathological Complete Response Following Preoperative Chemoradiation in Fixed (T4) Distal Rectal Cancer. Int J Radiat Oncol Biol Phys 42(S2): 163(#77), 1998.
19.
Regine WF, Mohiuddin M, Tibbs PA, Dempsey RJ, Young B, Kryscio RJ, Foon KA, Markesbery WR, Patchell RA. A Randomized Prospective Trial of the Benefit of Postoperative Radiotherapy in the Treatment of Single Metastases to the Brain. Int J Radiat Oncol Biol Phys 42(S2): 196(#144), 1998.
20.
Mohiuddin Me, Mohiuddin Ma, Patel N, Dey S, Chendil D, Regine WF, Mohiuddin Mo, Ahmed MM. 5FU Sensitizes Radiation by a Mechanism Independent of p53 to Cause Clonogenic Inhibition and Apoptosis in Pancreatic Tumor Cell Lines. Int J Radiat Oncol Biol Phys 42(S2): 236(#2018), 1998.
21.
Sloan DA, Witzke DB, Plymale MA, Sloan PA, Regine WF, Valentino J, Schwartz RW, Kenady DE. Development of a Multidisciplinary Workshop for Teaching Head and Neck Oncology: Results of a Pilot Study. Journal of Cancer Education 13(S): 15, 1998.
22.
Kudrimoti M, Regine WF, John W, McGrath P, Hanna N, Mohiuddin M. Concurrent Infusional Gemcitabine and Radiation in the Treament of Advanced Unresectable GI Malignancy: A Phase I/II Study. Proceedings of ASCO, J Clin Oncol 18: 242a(#928), 1999.
23.
Regine WF. Non – Invasive Treatment for Acoustic Neuromas. Physician’s Practice Digest 9(3): A3, 1999.
24.
Carlsen GH, Regine WF, Valentino J, Sloan DA, Kenady DE, Meigooni AS, Mohiuddin M. Use of Spatially Fractionated (GRID) Radiation as a Novel Means of Dose Escalation in the Treatment of Large Volume Carcinomas Involving Head and Neck Sites. Lung Cancer 25(3): 286, 1999.
25.
Regine WF, Young AB. Gamma Knife Radiosurgery Now an Option for More Patients. Physician’s Practice Digest 9(6): A4-5, 1999.
26.
Sanghavi SN, Miranpuri BS, Chapell R, Mabanta S, Suh JH, Regine WF, Weltman E, Sneed PK, Goetsch SJ, Breneman JC, Sperduto PW and MAPP, Scott C, Buatti JM, Mehta MP. Multi-Institutional Survival Analysis of Brain Metastases Patients Treated with Radiosurgery,Stratified by RTOG RPA Classification. Int J Radiat Oncol Biol Phys 45(S3): 171(#48), 1999.
27.
Mohiuddin M, Kudrimoti M, Regine WF, McGrath P, Hanna N, Meeker T, John W. Concurrent Infusional Gemcitabine and Radiation in the Treament of Advanced Unresectable GI Malignancies. Int J Radiat Oncol Biol Phys 45(S3):255(#204), 1999.
28.
Gamburg ES, Regine WF, Patchell RA, Strottmann JM, Mohiuddin M, Young AB. The Prognostic Significance of Midline Shift on Survival of Patients Presenting with Glioblastoma Multiforme. Int J Radiat Oncol Biol Phys 45(S3):321(#2085), 1999.
William F. Regine, M.D. Curriculum Vitae - Page 19
29.
Regine WF, Patchell RA, Strottman J, Sanders M, Meigooni AS, Young BA. A Phase I Study of Fractionated Stereotactic Radiosurgery and Conventional External Beam Radiation Therapy. Scientific program LINAC Radiosurgery – 1999 Meeting, 68, 1999.
30.
Staryszak M, Meigooni AS, Drogin A, Gearheart D, Meade J, Sanders M, Young B, Regine WF. Measurement of Dose to the Normal Tissue for Treatment with Multiple Targets Using Radiosurgery Techniques. Scientific program LINAC Radiosurgery – 1999 Meeting, 58, 1999.
31.
Nicol B, Regine WF, Courtney C, Meigooni AS, Sanders M, Young B. Gamma Knife Radiosurgery for Trigeminal Neuralgia: Our Experience Using 90 Gy. Scientific Program 10th International Meeting of the Leksell Gamma Knife Society, 159, 2000.
32.
Regine WF, Patchell RA, Strottman J,Meigooni AS, Sanders M, Young BA. Combined Fractionated Gamma Knife Stereotactic Radiosurgery and Conventional Radiation Therapy for UnfavorableGliomas: A Phase I Study. Scientific Program 10th International Meeting of the Leksell Gamma Knife Society, 52, 2000.
33.
Regine WF, Valentino J, Arnold S, Haydon RC, Sloan DA, Kenady DE, Pulmano C, Mohiuddin M. High-Dose Intra-Arterial Cisplatin Boost with Hyperfractionated Radiation Therapy for Advanced Squamous Cell Carcinoma of the Head and Neck. Proceedings of ASCO, J Clin Oncol 19:421a(#1662), 2000.
34.
Regine WF. The Role of Radiotherapy in Colorectal Cancer. Proceedings of the 4th Annual National VA Oncology Symposium, VHSJ 5(7): 21-22, 2000.
35.
Regine WF, Scott C, Murray K, Curran W. Neurocognitive Outcome in Brain Metastasis Patients Treated with Accelerated Fractionation vs. Accelerated Hyperfractionation Whole Brain Radiotherapy: An Analysis from RTOG Study 91-04. Int J Radiat Oncol Biol Phys 48(S3):158(#94), 2000.
36.
Fowler BZ, Suntharalingham M, Koffman BH, Nichols B, Chin L, Young AB, Regine WF. Gamma Knife Stereotactic Radiosurgery for Synchronous versus Metachronous Solitary Brain Metastases from Non-Small Cell Lung Cancer. Int J Radiat Oncol Biol Phys 48(S3):300(#2071), 2000.
37.
Regine WF, Huhn JL, Strottmann JM, Patchell RA, Sanders M, Meigooni AS, Young AB. Gamma Knife Radiosurgery Alone following High Resolution MRI in Patients with Newly Diagnosed Brain Metastases: Results and Implications. J Neuro-Onc 2(4): 289-290(#180), 2000.
38.
Regine WF, Valentino J, Arnold S, Sloan D, Kenady D, Strottmann J, Mohiuddin M. A Phase II Study of Concomitant Hyperfractionated Radiaiton Therapy and Double Dose Intra –Arterial Cisplatin for Squamous Cell Carcinoma of the Head and Neck. Proceedings of ASCO, J Clin Oncol 20:234a(#935), 2001.
39.
Regine WF, Patchell R, Huhn J, Meigooni AS, Sanders M, Young B. Risk of Symptomatic Brain Tumor Recurrence and Neurologic Deficit Following Gamma Knife Radiosurgery Alone for Single Metastases to the Brain. Proceedings of 14th International Conference on Brain Tumor Research and Therapy 117(#144), 2001.
40.
Regine WF, Reid B, Patchell RP, St. Clair W, Sims J, Sanders M, Young B. Efficacy of 20 Gy Gamma Knife Stereotactic Radiosurgery With or Without Whole Brain Radiation Therapy For < 2 cm Brain Metastases. Proceedings of 5th International Stereotactic Radiosurgery Society Congress 33(#I:H), 2001.
41.
Regine WF. The Radiation Oncologist’s Perspective on Stereotactic Radiosurgery. Proceedings of International Conference on Technology in Cancer Research and Treatment in the New Millennium 15-16, 2001.
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42.
Regine, WF, Huhn JL, Patchell R, Huhn J, Meigooni AS, Sanders M, Young B. Risk of Symptomatic Brain Tumor Recurrence and Neurologic Deficit Following Gamma Knife Radiosurgery Alone for Single Metastases to the Brain. J Neuro-Onc 3(1): S35(144), 2001.
43.
Kudrimoti M, Regine WF, Meigooni AS, Ahmed M, Mohiuddin M. High Dose Spatially Fractionated Radiation (GRID): A New Paradigm in the Management of Advanced Cancers. Int J Radiat Oncol Biol Phys 51(S1):3(#86), 2001.
44.
Sathishkumar S, Dey S, Meigooni AS, Regine WF, St. Clair WS, Ahmed MM, Mohiuddin M. The Impact of TNF â&#x20AC;&#x201C; alpha Induction on Therapeutic Efficacy Following High Dose Spatially Fractionated (GRID Int J Radiat Oncol Biol Phys 51(S1):3(#2001), 2001.
45.
Rogosinska A, Regine WF, Kryscio RJ, Tibbs PA, Young AB, Patchell RA. Prognostic Factors in Patients with Resected Single Brain Metastases: Evaluation of Recursive Partitioning Analysis (RPA) Classes and II. Int J Radiat Oncol Biol Phys 51(S1):3(#238), 2001.
46.
Arnold S, Regine WF, Valentino J, Spring P, DeSimone P, Kudrimoti M, Kenady D, Ahmed M, Mohiuddin M. Use of Low-Dose Fractionated Radiation (LDFRT) as a Chemosensitizer of Neoadjuvant Paclitaxel (P) and Carboplatin (CBCDA) for Locally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN) Results of a New Treatment Paradigm. Proceedings of ASCO, J Clin Oncol 21:231a(#921), 2002.
47.
Regine WF, Schmitt FA, Scott C, Dearth CS, Patchell R, Nichols Jr, RC, Gore E, Franklin III, RL, Suh J, Mehta M. Feasibility of Neurocognitive Outcome Evaluations in Patients with Brain Metastases in a MultiInstitutional Cooperative Group Setting: Results of Radiation Therapy Oncology Group (RTOG) Trial BR-0018. Int J Radiat Oncol Biol Phys 54(S1): 49(#79), 2002.
48.
Shehata MK, Young AB, Reid B, Patchell RA, St. Clair W, Simms J, Meigooni AS, Mohiuddin M, Regine WF. Stereotatic Radiosurgery (SRS) of 468 Brain Metastases < 2 cm: Implications for SRS Dose and Whole Brain Radiation Therapy (WBRT). Int J Radiat Oncol Biol Phys 54(S1):94(#157), 2002.
49.
Kudrimoti M, Regine WF, Huhn JL, Meigooni AS, Ahmed M, Mohiuddin M. Spatially
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Fractionated Radiation Therapy (SFR) in the Palliation of Large Bulky (>8 cm) Melanomas Int J Radiat Oncol Biol Phys 54(S1):342(#2225), 2002. 50.
Patchell R, Tibbs PA, Regine WF, Payne R, Saris S, Kryscio RJ, Young B. A randomized trial of direct decompressive surgical resection in the treatment of spinal cord compression caused by metastasis. Proceedings of ASCO, J Clin Oncol 22:1(#2), 2003.
51.
Regine WF, Tibbs PA, Young A, Payne R, Saris S, Kryscio RJ, Patchell RA. Metastatic Spinal Cord Compression: A Randomized Trial of Direct Decompressive Surgical Resection Plus Radiotherapy vs. Radiotherapy Alone. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 57(2):S125(#3), 2003.
52.
Petit JH, Herman JM, Biggins T, Regine WF, Chin LS. Repeat Gamma Knife Radiosurgery for Refractory or Recurrent Trigeminal Neuralgia. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 57(2):S137 (#22), 2003.
53.
Kwok Y, DiBiase S, Yovino S, Arena C, Temple R, Regine WF, Amin P, Guo C, Chin L. Improved Outcome with Adequate Dural Tail Coverage in Patients with Intracranial Meningiomas Treated with . Gamma Knife Stereotactic Radiosurgery. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 57(2):S324-325(#1106), 2003.
54. Regine WF. Adjuvant Multimodality with Gemzar Versus 5-Fluorouracil in Pancreatic Cancer: Status of U.S. Intergroup Trial. Proceedings of Chemotherapy Foundation Symposium XXI 29-30(#20), and Cancer Investigations Vol. 22, 2003. 55. Regine WF. Tibbs PA, Young A, Payne R, Saris S, Kryscio RJ, Patchell RA. Metastatic Spinal Cord Compression: A Randomized Trial of Direct Decompressive Surgical Resection Plus Radiotherapy vs.
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Radiotherapy Alone. Proceedings of RSNA, Radiology, 2003. 56. Martin NE, Brunner TB, Kiel KD, DeLaney TF, Regine WF, Mohiuddin M, Rosato EF, Haller DG, Stevenson JP, Smith D, Pramanik B, Tepper J, Tanaka WK, Morrison B, Deutsch P, Gupta AK, Muschel RJ, McKenna WG, Bernhard EJ, Hahn SM. A Phase I Trial of the Dual Farnesyltransferase and Geranylgeranyltransferase Inhibitor L-778,123 and Radiotherapy for Locally Advanced Pancreatic Cancer. Proceedings of ASCO, J Clin Oncol 23 (#4098), 2004. 57.
Arnold S, Kudrimoti M, Regine WF, Valentino J, Spring P, Kenady D, Ahmed M, Mohiuddin, M. Lowdose Fractionated Radiation (LDFRT), Paclitaxel (P) and Carboplatin (CB) and induction therapy for locally advanced squamous cell carcinoma of the head and new (SCCHN) â&#x20AC;&#x201C; Two year follow-up. Proceedings of ASCO, J Clin Oncol 23 (#5593), 2004.
58.
Arnold S, Kudrimoti M, Valentino J, Spring P, Ahmed M, Regine WF, Given C, Kenady D, Mohiuddin M. Low-dose Fractionated Radiation (LDFRT) as a Potentiator of Neoadjuvant Paclitaxel (P) and Carboplatin (C) in Locally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN). Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 60(1) S322(#1112), 2004.
59.
Dutta PR, Kwok Y, Herman JM, Chin LS, Colliver C, St. Clair WH, Petit JH, Young B, Regine WF. Comparison of Repeat GK-SRS for Refractory or Recurrent Trigeminal Neuralgia: Does Dose Matter. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 60(1) S405(#2118), 2004.
60.
Shehata MK, Regine WF, St. Clair W, Sims J, Sanders M, Meigooni AS, Mohiuddin M, Young A. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 60 (1) S411(#2129), 2004.
61.
Kwok Y, Murali N, Chin L, Bangalore M, Amin P, Regine WF. Long-Term Results of Gamma Knife Stereotactic Radiosurgery for Non-Functioning Pituitary Adenomas. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 60(1) S551 (#2361), 2004.
62.
Gaugler JE, Linder J, Hanna N, Given CW, Tolbert VE, Regine WF. The Emotional Effects of Cancer Care on Family Members: A Multidimensional Analysis. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 60(1) S568 (#2389), 2004.
63.
Kudrimoti M, Mohiuddin M, Ahmed M, Meigooni AS, Hanna N, Regine WF, Huhn J. Use of High Dose spatially Fractionated Radiation (GRID Therapy) in Management of Large, Poor Prognostic Stage III (>10cms) Soft Tissue Sarcomas. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 60(1) S575 (#2400), 2004.
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64. Arnold SM, Kudrimoti M, Valentino J, Spring P, Ahmed M, Regine WF, Kenady D, Given C, Mohiuddin M. Potentiating the Effect of Chemotherapy with Low-Dose Fractionated Radiation (LDFRT) in Locally Advanced Squamous Cell Carcinoma of the Head and Neck. Proceedings of ASCO, J Clin Oncol 23 (#3184), 2005. 65. Regine WF, Hanna N, Garofalo MC, Doyle A, Kataria R, Simms J, Mohiuddin, M. Radiation Therapy (RT) as a Chemosensitizer of Gemcitabine (G) in Patients with metastatic/Unresectable Tumors of the Gastrointestinal (GI) Tract â&#x20AC;&#x201C; a Phase I/II Study Exploring a New Treatment Paradigm. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 63(2) S13 (#23), 2005. 66.
Dhople AA, Kwok Y, Jaboin J, Sorkin JD, Slawson R, Amin P, Chin LS, Regine WF. Efficacy and Quality of Life in Patients with Atypical Trigeminal Neuralgia Treated with Gamma-Knife Stereotactic Radiosurgery. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 63(2) S106 (#175), 2005.
67.
Garofalo MC, Malloy P, Amin P, Jaboin J, Gutt R, Van Echo D, Regine WF. Treatment of Unresectable Chemorefractory Liver Metastases with Selective Intrahepatic Application of Yttrium-90 Microsphere (SIR-Spheres): Early U.S. Experience. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 63(2) S161 (#1028), 2005.
68.
Jaboin J, James R, Stallmeyer B, Shaw N, Slawson R, Amin P, Chin LS, Simard J, Regine WF. An Analysis of Dose-Staged Stereotactic Radiosurgery for Large Cerebral Arteriovenous Malformations. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 63(2) S258, (# 2048), 2005.
69.
Patel S, Kwok Y, Shepard D, Chin LS, Slawson R, Amin P, Regine WF. Evaluating the Influence of DoseRate on Outocme with Gamma Knife Stereotactic Radiosurgery in the Treatment of Trigeminal Neuralgia. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 63(2) S429 (#2336), 2005.
70. WF Regine, KW Winter, R Abrams, H Safran, JP Hoffman, A Konski, AB Benson, JS MacDonald, CG Willett, TA Rich. RTOG 9704 A Phase III study of adjuvant pre and post chemoradiation (CRT) 5-FU vs. gemcitabine (G) for resected pancreatic adenocarcinoma. Proceedings of ASCO Annual Meeting, June 2006. 71. SM Arnold, WW Graham, J Valentino, Y Brill, WF Regine, P Spring, C Given, M Mohiuddin, W St. Claire, M Kudrimoti. Results of intraarterial cisplatin and hyperfractionated radiotherapy in locally advanced cancer of the oropharynx and oral cavity. Proceedings of ASCO Annual Meeting, June, 2006. 72.
GW Warren, SM Arnold, G Curtis, J Valentino, Y Brill, WF Regine, PM Spring, M Mohiuddin,
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WH St. Clair, MR Kudrimoti. The effect of induction therapy with carboplatin-paclitaxel and low dose radiotherapy followed by hyperfractionated radiotherapy and intraarterial chemotherapy on advanced cancers of the head and neck. Proceedings of ASCO Annual Meeting, June, 2006. 73.
Abrams RA, Winter KA, Regine WF, Safran H, Hoffman JP, Konski AA, Benson AB, Macdonald JS, Rich TA, Willett CG. RTOG 97-04 – Radiotherapy Quality Assurance (QA) Review and Survival. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 66(3) S22 (#39) 2006.
74.
Regine WF, Winter KA, Abrams RA, Safran H, Hoffman JP, Konski A, Benson AB, Macdonald JS, Willett, CG, Rich TA. A Phase III Intergroup Trial (RTOG 97-04) of Adjuvant Pre and Post Chemoradiation (CRT) 5-FU vs. Gemcitabine (G) for Resected Pancreatic Adenocarcinoma. Proceedings of ASTRO, Int. J Radiat Oncol Biol Phys 66(3) S23 (#42) 2006.
75.
Yu CX, Feng Y, Castro-Pareja C, Shekhar R, Regine WF. On-Line Aperture Morphing – An Inter-Fraction Image Guidance Strategy. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 66 (3)S51, (# 91), 2006.
76.
Garofalo MC, Winter K, Regine WF, Rich TA, Komaki R, Tepper JE, Gunderson LL, Willett CG. Recursive Partitioning Analysis (RPA) of Prognostic Factors in Six Radiation Therapy Oncology Group (RTOG) Trials of Chemoradiotherapy for Unresectable Pancreatic Cancer. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 66(3) S80, (# 144), 2006.
77.
Flannery T, Kwok Y, Krasna M, Chin L, Shehata M, Kremer M, Jaboin J, Suntha M, Regine WF. The Impact of Definitive Thoracic Management on Long-Term Survival in Patients with Synchronous, Solitary Brain Metastases from Non-Small-Cell Lung Cancer Treated with Stereotactic Radiosurgery. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 66(3) S85, (# 152), 2006.
78.
Kudrimoti MR, Warren G, Valentino J, Spring P, Brill Y, Given C, St. Clair W, Mohiuddin M, Regine WF, Arnold S. Stratification of Therapy Basd on Response to Novel Induction Therapy in Stage III/IV Squamous Cell Carcinoma of the Head/Neck (SCCA H/N). Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 66(3) S442, (# 2417), 2006.
79. Arnold SM, Warren GW, Valentine J, Brill Y, Regine WF, Spring P, Given C, Mohiuddin M, Huhn JL, Kudrimoti M. Long Term Results of Regional Control in Stage III-IV Node Positive Patients with Squamous Cell Carcinoma of the Head an Neck Using Hyperfractionated Radiation Therapy and Intraarterial Chemotherapy (HYPERRADPLAT). Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 66 (3)S446, (# 2427), 2006. 80. Crane CH, Winter K, Regine WF, Safran H, Rich T, Curran W, Wolff R, Willett C. A Phase II Study of Bevacizumab with concurrent Capecitabine and Radiation Followed by Maintenance Gemcitabine and Bevacizumab for Lacally Advanced Pancreatic Cancer: RTOG PA0411. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 69 (3) S77, (# 136), 2007. 81. Regine WF, Garcia M, Berger AC, Abrams RA, Safran H, Konski A, Benson AB, MacDonald JS, Rich TA, Willett CG. Post-Resectional CA 19-9 Values ≥ 90 are Associated with Significantly Worse Survival in Patients with Pancreatic Carcinoma Treated with Adjuvant Therapy on RTOG 9704 – Implications for Current and Future Trials. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 69 (3) S78, (# 137), 2007. 82. Kwok Y, Won M, Regine WF, Mehta M, Schmitt F, Patchell RA, Watkins-Bruner D. Neurocognitive Impact of Whole-Brain Radiation on Patients with Brain Metastases: Secondary Analysis of RTOG BR-0018. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 69 (3) S103, (# 184), 2007.
William F. Regine, M.D. Curriculum Vitae - Page 25
83.
Adams JR, Dhople AA, Kwok Y, Yu CX, Simard M, Regine WF. Long Term Follow-up of Gamma Knife Stereotactic Radiosurgery for Trigeminal Neuralgia. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 69 (3) S122, (# 221), 2007.
83. Dhople AA, Adams JR, Kwok Y, Yu CX, Simard M, Maggio WW, Regine WF. Long Term Follow-up of Repeat Gamma Knife Stereotactic Radiosurgery for Refractory or Recurrent Trigeminal Neuralgia. Proceedings of ASTRO, Int J Radiat Oncol Biol Phys 69 (3) S123, (# 222), 2007. BOOK CHAPTERS/TEXTBOOKS: 1.
Regine WF. Postoperative Adjuvant Therapy for Pancreatic Cancer: Past, Present, and Future Trial Development. In: MD Anderson Solid Tumor Oncology Series: Pancreatic Cancer. Evans DB, Pisters PWT, Abbruzzese JL, eds. Spinger-Verlag, 2001;235-242.
2.
Regine WF, Hanna N, DeSimone P, Cohen A. Rectal Cancer. In: Clinical Oncology, 3rd Edition Abeloff M, ed. Churchill Livingston, 2003; 1943-1966.
3.
Kwok Y, Garofalo MC, Regine WF. Postoperative Adjuvant Therapy and the Rationale for the US Intergroup Trial. In: â&#x20AC;&#x153;Van Hoff D, Evans D, Hruban, RH, eds. Jones and Bartlett, 2005;395-404.
4.
Garofalo MC, Flannery T, Regine WF. The Case for Adjuvant Chemoradiation for Pancreatic Cancer. In: Best Practice & Research Clinical Gastroenterology, eds. Elsevier, Vol 20, No 2, pp. 403-416, 2006.
5.
Patel S, Garofalo MC, Regine WF. Role of Radiotherapy in Treatment of Pancreatic Cancer. (Chapter 81) In: Beger H, Bulcher M, Kozarek R, eds. The Pancreas, 2 nd Edition Blackwell Publishing, Ltd, 2006 (In press).
6.
Kwok Y, Patchell RA, Regine WF. Palliation of Brain and Spinal Cord Metastases. In: Principles & Practice of Radiation Oncology, 5th Edition, Lippincott Publishing (In Press).
7.
Suh JH, Barnett GH, Regine WF. Stereotactic Radiosurgery for Brain Metastases. In: Chin LC, Regine WF eds. Principles & Practice of Stereotactic Radiosurgery. Springer-Verlag Publishing. (In Press)
William F. Regine, M.D. Curriculum Vitae - Page 26
8.
Patchell RA, Regine WF. Whole Brain Radiation Therapy for Brain Metastases. In: Chin LC, Regine WF, eds. Principles & Practice of Stereotactic Radiosurgery. Springer-Verlag Publishing (In Press).
9.
Chin LC, Regine WF., eds. Principles & Practice of Stereotactic Radiosurgery. Springer-Verlag Publishing (In Press).
PRESENTATIONS: NATIONAL 1. 2.
Murine Bone Marrow Macrophage Colony-Forming Unit Response to Radiation +40-420C: Potential Implications for Combined Total Body Irradiation and Hyperthermia. 33rd Annual Scientific Meeting of the American Society for therapeutic Radiology and Oncology, Washington, DC, November, 1991. [Poster] Evaluation of Local Control with Selective Use of Low-Dose Irradiation Following Induction/Preoperative Chemotherapy for Locally AdvancedRhabdomyosarcoma. 35th Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, New Orleans, LA, October, 1993.
3.
Use of Altered Radiation (RT) Dose and Fractionation in Patients with Unresectable Rhabdomyosarcoma (RMS) Based Upon Disease Status Following Induction Therapy:The St. Jude experience.34th Annual Meeting of the American Society of Clinical Oncology, Dallas, TX, May, 1994. [Poster]
4.
Efficacy of Postoperative Irradiation for Recurrent Squamous Cell Carcinoma of the Head and Neck. 4 th International Conference on Head and Neck Cancer, Toronto, Canada, July, 1996.
5.
Dose-Intensive Chemoradiation Following Pancreaticoduodenectomy for Pancreatic Carcinoma â&#x20AC;&#x201C; A Phase I Study. 38th Annual Scientific Meeting of the American Society of Radiology and Oncology, Los Angeles, CA, October, 1996.[Poster]
6.
Results of Postoperative Irradiation for Squamous Cell Carcinoma of the Head and Neck: Is There a Difference Between Primary and Recurrent Disease? 39th Annual Scientific Meeting of the American Society of Radiology and Oncology, Orlando, FL, October, 1997. [Poster]
7.
Toxicity and Response of High-Dose Intra-Arterial Cisplatin and Hyperfractionated Radiation Therapy in Patients with Locally Advanced Primary Squamous Cell Carcinoma of the Head and Neck. Combined program of theamerican society for head and neck surgery and the society of head and neck surgeons, West Palm Beach, May, 1998.
8.
Results of High-Dose Intra-Arterial Cisplatin and Hyperfractionated Radiation Therapy in Patients with High Volume Unfavorable Squamous Cell Carcinoma of the Head and Neck. 34th Annual Meeting of the American Society of Clinical Oncology, Los Angeles, CA, May, 1998. [Poster]
9.
A Randomized Prospective Trial of the Benefit of Postoperative Radiotherapy in the Treatment of Single Metastases to the Brain. 40th Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, Phoenix, AZ, October, 1998.
William F. Regine, M.D. Curriculum Vitae - Page 27
10.
A Phase I Study of Fractionated Stereotactic Radiosurgery and Conventional External Beam Radiation Therapy for Unfavorable Intracranial Tumors. LINAC Radiosurgery â&#x20AC;&#x201C; 1999 Meeting, Orlando, FL, December, 1999.
11.
Combined Fractionated Gamma Knife Stereotactic Radiosurgery and Conventional Radiation Therapy for UnfavorableGliomas: A Phase I Study. 10th International Meeting of the Leksell Gamma Knife Society, Squaw Valley, CA, April, 2000.
12.
High-Dose Intra-Arterial Cisplatin Boost with Hyperfractionated Radiation Therapy for Advanced Squamous Cell Carcinoma of the Head and Neck. 36th Annual Meeting of the American Society of Clinical Oncology, New Orleans, LA, May, 2000. [Poster Discussion]
13.
Neurocognitive Outcome in Brain Metastasis Patients Treated with Accelerated Fractionation vs. Accelerated Hyperfractionation Whole Brain Radiotherapy: An Analysis from RTOG Study 91-04. 42nd Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, Boston, MA, October, 2000.
14.
Gamma Knife Radiosurgery Alone following High Resolution MRI in Patients with Newly Diagnosed Brain Metastases: Results and Implications. 5th Annual Meeting of the Society for Neuro-Oncology, Chicago, IL, November, 2000.
15.
A Phase II Study of concomitant Hyperfractionated Radiation Therapy and Double Dose Intra-Arterial Cisplatin for Squamous Cell Carcinoma of the Head and Neck. 37th Annual Meeting of the American Society of Clinical Oncology, San Francisco, CA, May, 2001. [Poster]
16.
Risk of Symptomatic Brain Tumor Recurrence and Neurologic Deficit Following Gamma Knife Radiosurgery Alone for Single Metastases to the Brain. 14th International Conference On Brain Tumor Research and Therapy, Asheville, NC, May, 2001. [Poster]
17.
Efficacy of 20 Gy Gamma Knife Stereotactic Radiosurgery With or Without Whole Brain Radiation Therapy for < 2 cm Brain Metastases. 5th International Stereotactic Radiosurgery Society Congress, Las Vegas, Nevada, June, 2001.
18.
Prognostic Factors in Patients with Resected Single Brain Metastases: Evaluation of Recursive Partitioning Analysis Classes I and II. 43rd Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, San Francisco, CA, November, 2001.
19.
Feasibility of Neurocognitive Outcome Evaluations in Patients with Brain Metastases in a MultiInstitutional Cooperative Group Setting: Results of Radiation Therapy Oncology Group (RTOG) Trial BR-0018. 44 th Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, New Orleans, LA, October, 2002.
20.
Metastatic spinal cord compression: A randomized trial of direct decompressive surgical resection plus radiotherapy vs. radiotherapy alone. 45th Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, Salt Lake City, UT, October 2003.
21.
Radiation Therapy as a Chemosensitizer of Gemcitabine in Patients with Metastatic/Unresectable Tumors of the Gastrointestinal Tract â&#x20AC;&#x201C; a Phase I/II Study Exploring a New Treatment Paradigm.
William F. Regine, M.D. Curriculum Vitae - Page 28
47th Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, Denver, CO, October 2005. 22.
23.
24.
A Phase III study of adjuvant pre and post chemoradiation 5-FU vs. gemcitabine for resected pancreatic adenocarcinoma. 42nd Annual Meeting of the American Society of Clinical Oncology, Atlanta, GA, June, 2006. RTOG 9704: A Phase III Study of Adjuvant Pre and Post Chemoradiation 5-FU vs. Gemcitabine for Resected Pancreatic Adenocarcinoma. 48th Annual Scientific Meeting of the American Society of Therapeutic Radiology and Oncology, Philadelphia, PA, November, 2006. Post-Resectional CA 19-9 Values â&#x2030;Ľ 90 Are Associated with Significantly Worse Survival In Patients With Pancreatic Carcinoma Treated With Adjuvant Therapy on RTOG 9704 â&#x20AC;&#x201C; Implications For Current And Future Trials. 49th Annual Scientific Meeting of the American Society of Therapeutic Radiology and Oncology, Los Angeles, PA, October, 2007. REGIONAL
1.
The Combined Modality Treatment of Rectal Cancer. Section on Radiation Oncology, Philadelphia Roentgen Ray Society Meeting, Philadelphia, PA, January, 1992.
2.
The Role of Radiation in the Treatment of Adenoid Cystic Carcinoma of the Palate. 22 nd Annual Radiation Oncology Clinical Research Seminar, Gainesville, FL, April, 1992.
3.
Pancreatic Cancer - Beyond Surgery is There a Role for Adjuvant Therapy? University of Kentucky/Department of Radiation Medicine Symposium: New Trends in the Management of G.I. Cancer, Lexington, KY, June, 1996.
4.
New Combined Treatment Modalities for Advanced Cancer of the Head and Neck. University of Kentucky/Department of Radiation Medicine Symposium: New Trends in the Management of Head and Neck Cancer, Lexington, KY, September, 1996.
5.
Use of Gamma Knife Radiosurgery in the Management and Treatment of Malignant Primary Brain Tumors. University of Kentucky Neurosciences Institute Symposium: New Trends in the Management of Central Nervous System Disease, Lexington, KY, February, 1997.
6.
Gamma Radiosurgery for Trigeminal Neuralgia. Kentucky Neurosciences Institute Symposium: New Trends in the Management of Trigeminal Neuralgia, Lexington, KY, July, 1997.
William F. Regine, M.D. Curriculum Vitae - Page 29
7.
Introducton to Gamma Knife Radiosurgery. The First Annual University of Kentucky Radiaton Therapy Conference, Lexington, KY, October, 1997.
8.
Current Status of Adjunctive Therapy Trials in the Management of Resectable Pancreatic Cancer. University of Kentucky/Department of Radiation Medicine Symposium: New Trends in the treatment of upper G.I. Cancer, Lexington, KY, August, 1999.
9.
High Dose Spatially Fractionated Radiation (GRID): A New Paradigm in the Management of Advanced Cancers. Second Annual Simon Kramer Institute Oncology Conference, New Philadephia, PA, August, 2002. [Poster]
10.
Radiotherapy & Surgery/Radiosurgery in the Treatment of Brain Metastases. Greenebaum Cancer Center Hematology/Oncology Grand Rounds, Baltimore, MD, September, 2003.
VISITING PROFESSORSHIPS AND INVITED PRESENTATIONS: 1.
All Rectal Cancers Are Not Alike - Optimizing the Use ofAdjuvant Therapy. “Visiting Professor” at the Department of Radiation Oncology,University of Maryland, Baltimore, MD, July 1997.
2.
Trimodality Therapy for Malignancies of the Gastrointestinal Tract: The Evolving Roles of Surgery, Chemotherapy and Radiation. “Invited Speaker” at St. Vincent’s Medical Center, Jacksonville, FL, January 1998.
3.
Adjuvant Therapy for Pancreatic Cancer: Current Status. “Invited Speaker” at Gulf Coast Medical Center, Panama City,FL, January 1999.
4. What is the Role of Radiotherapy in the Management of Colorectal Cancer? “Invited Speaker” at 4 th Annual National VA Oncology Symposium, Washington DC, October 1999. 5.
What are the Roles of Adjuvant Therapy in Pancreatic Cancer and Radiation Therapy in the Management of Colorectal Cancer: Current Status. “Invited Speaker” at Centre Community Hospital, State College, PA, February 2000.
6. Preoperative Chemoradiation in Fixed (T4) Distal Rectal Cancer: Dose Time Factors for Pathologic Complete Response. “Invited Speaker” at American College of Surgeons, Kentucky Chapter, Spring Meeting, Lexington, KY, March, 2000. 7. Is Whole Brain Radiation Therapy a Standard of Care Following resection of a Single Brain Metastases? Yes. “Invited Speaker & Panelist” for Panel Presentation – ‘Controversies in the Management of Brain Metastases’ at 42th Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, Boston, MA, October 2000.
William F. Regine, M.D. Curriculum Vitae - Page 30
8. The Radiation Oncologist’s Perspective on Stereotactic Radiosurgery. “Invited Speaker” at International Conference on Technology in Cancer Research and Treatment in the New Millennium, Albany, NY, June 2001. 9. CNS Criteria Development for the common Toxicity Criteria. “Invited Speaker & Panelist” for ‘Validation Studies and Criteria Development Process’ at NCI Sponsored Late Effects Workshop, St. Petersburg Beach, FL, April, 2002. 10. Something Old, Something New, and Something Blue: Evolving Paradigms from the University of Kentucky Head & Neck & GI Cancer Programs. “Invited Speaker” at Gulf Coast Medical Center, Panama City, FL, July 2002. 11. Use of Low–Dose Radiation as a Chemosensitizer for H&N Carcinomas–A New Treatment Paradigm. “Invited Speaker” at Sixth Annual International Conference & Workshop-New and Future Developments in Radiotherapy. Las Vegas, NV, August, 2002. 12. Locally Advanced Squamous Cell Carcinoma of the Head and Neck: Old and New Treatment Paradigms – The Joseph Marconis, MD Memorial Lecture. “Invited Speaker” at Second Annual Simon Kramer Institute Oncology Conference. New Philadephia, PA, August 2002.
13. Radiotherapy and Surgery/Radiosurgery in the Treatment of Brian Metastases. “Invited Speaker” at Current Approaches To The Treatment Of Brain Metastases Symposium, CME Symposium in conjunction with 44th Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, New Orleans, LA, October 2002. 14. Current Management of Low-grade Gliomas. “Invited Speaker” at Exploring Advances in the Management of Gliomas Symposium. CME Symposium in conjunction with 45th Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, Salt Lake City, UT, October 2003. 15. Adjuvant Multimodality Treatment with Gemcitabine vs. 5-FU in Pancreatic Cancer: Status of U.S. Intergroup Trial. “Invited Speaker” at Chemotherapy Foundation Symposium XXI. Innovative Cancer Therapy for Tommorrow. New York City, NY, November 2003. 16. Metastatic spinal cord compression: A randomized trial of directo decompressive surgical resection plus radiotherapy vs. radiotherapy alone. “Invited Speaker” at Radiological Society of North American Scientific Assembly and Annual Meeting Program. Chicago, IL, December 2003. 17. Quality of Life in Brain Neoplasms. “Invited Speaker” at Neuro-Oncology 2004 – Current Concepts Meeting, Cleveland Clinic Education Foundation. Orlando, FL, February 2004. 18. “Pancreatic Cancer: Status of Adjuvant Multimodality U.S. Intergroup Phase III Trial” and “Metastatic Epidural Spinal Cord Compression (MESCC): Clinical Update”. “Visiting Professor” at the Department of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania, September 2004. 19. Neurologic sequelae of Brain Metastases: Recognition and Impact on Therapeutic Approach. “Invited Speaker” at WBRT for the Management of Brain Metastases: Novel Approaches to Improve the Therapeutic Index, CME Syposium in conjunction with 46th Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology. Atlanta Georgia, October 2004.
William F. Regine, M.D. Curriculum Vitae - Page 31
20. Management of GI Tumors-ASTRO 2004 Review. “Invited Speaker” at The Cleveland Clinic Callahan Center for Radiation Oncology 6th Annual ASTRO Review 2004. Cleveland, OH, November 2004. 21. Pancreatic Cancer: Review of Adjuvant Multimodality Trials and Status of U.S. Intergroup Phase III Trial. “Visiting Professor” at The Department of Radiation Oncology, Cleveland Clinic, Cleveland, OH, November 2004. 22. Malignant Gliomas: ‘Impacting Survival with New Treatment Strategies’ and ‘State-of-the-Art Treatment Approaches for Brain Metastases’ – “Invited Speaker” at Central Baptist Hospital, Cancer Center, Lexington Kentucky, February 2005 23. ‘State-of-the-Art Treatment Approaches for Brain Metastases’ – “Invited Speaker” at Southern Illinois Cancer Center, Marion, Illinois, February 2005. 24. ‘State-of-the-Art Treatment Approaches for Brain Metastases’ – “Invited Speaker” at Norris Cancer Center at USC, Los Angeles, CA, March 2005. 25. ‘Use of Gamma Knife Radiosurgery for Brain Tumors’ – “Invited Speaker” at Baltimore Oncology Club annual meeting, Sheraton Baltimore North, Towson, MD, March 2005. 26. ‘State-of-the-Art Treatment Approaches for Brain Metastases’ – “Invited Speaker” at Akron City Hospital, Akron City, OH, March 2005. 27. ‘State-of-the-Art Treatment Approaches for Brain Metastases’ – “Invited Speaker” at Houston Northwest Cancer program, Houston, TX, April 2005. 28. ‘State-of-the-Art Treatment Approaches for Brain Metastases’ – “Invited Speaker” at Sinai Hospital Cancer Institute, Baltimore, MD May 2005. 29. ‘State-of-the-Art Treatment Approaches for Brain Metastases’ – “Invited Speaker” at Tate Cancer Center, Glen Burnie, MD, May 2005. 30. ‘State-of-the-Art Treatment Approaches for Brain Metastases’ – “Invited Speaker” at Pluta Cancer Center, Rochester, NY, May 2005. 31. ‘Resolved: Currently available Adjuvant Therapies of Pancreatic Cancer are effective – Agree’ (Debate) “Invited Speaker” at International Society of Gastrointestinal Oncology – The 2005 Gastrointestinal Oncology Conference, Arlington, VA, July 2005. 32. ‘Pancreatic Cancer – Adjuvant Postoperative Chemoradiation’ - “Invited Speaker” at 12 th International Gastrointestinal Cancer Conference, Charlottesville, VA, October 2005. 33. ‘Glioblastoma Multiforme (& AA): The Multidisciplinary Approach to Treatment’ - “Invited Speaker” for Christiana Medical Center at The Hilton, Wilmington, DE, October 2005. 34. ‘Glioblastoma Multiforme (&AA): The Multidisciplinary Approach to Treatment’ – “Invited Speaker” for University of Kentucky, Markey Cancer Center, Lexington, KY, December 2005. 35. ‘Management of Brain Metastases: Concepts and Controversies’ “Invited Speaker” Harbor Hospital, Baltimore, MD April 2006. 36. ‘Brain Metastases: Truths and Misconceptions’: “Visiting Professor” at the Department of Radiation Oncology and Molecular Radiation Sciences, The Johns Hopkins University, Baltimore, MD, April 2006.
William F. Regine, M.D. Curriculum Vitae - Page 32
37. ‘Management of Brain Metastases’: Radiosurgery, Whole Brain Radiation Therapy and Quality of Life. “Invited Speaker” Washington Hospital Center, Washington, DC, May 2006. 38. ‘Management of Metatatic Brain Tumors - A Case Study “Invited Speaker” Sixth Annual Simon Kramer Institute Oncologic Symposium, New Philadelphia, PA, May 2006. 39. ‘Management of Brain Metastases: Concepts and Controversies’ “Invited Speaker” University of New Mexico Cancer Research and Treatment Center, Albuquerque, NM, June, 2006. 40. ‘Should Whole Brain Radiation Therapy follow Focal Therapy of a Single and Multiple Brain Metastases? “Invited Speaker” at Educational Session, 42nd Annual Meeting of the American Society of Clinical Oncology, Atlanta, GA, June, 2006. 41. ‘Management of Brain Metastases: Concepts and Controversies’ “Visiting Professor” at University of Colorado, Anschutz Cancer Pavillion, Aurora, CO, June, 2006. 42. ‘Pancreatic Cancer – Adjuvant Postoperative Chemoradiation: Where We Have Been and Where We Are Going; “Invited Speaker” at Southern Illinois Cancer Center, Marion, Illinois, June, 2006. 43. ‘Management of Brain Metastases: Concepts and Controversies’ “Visiting Professor” at University of Virginia, Charlottesville, VA, June, 2006. 44. ‘Management of Brain Metastases: Concepts and Controversies’ “Visiting Professor” at Oregon Health and Science University, Department of Radiation Oncology, Portland OR, July, 2006. 45. ‘Management of Brain Metastases: Concepts and Controversies’ – “Invited Speaker” at Central Baptist Hospital, Cancer Center, Lexington KY, July, 2006. 46. ‘Management of Brain Metastases: Concepts’ – “Invited Speaker” for University of Kentucky, Markey Cancer Center, Lexington, KY, July, 2006. 47. ‘Management of Brain Metastases: Concepts and Controversies’ “Visiting Professor” at University of Louisville/James Brown Cancer Center and Department of Radiation Oncology, Louisville, KY, July, 2006. 48. ‘Management of Brain Metastases: Concepts and Controversies’ “Visiting Professor” at University of Texas Southwest Medical Center and Department of Radiation Oncology, Dallas TX, July, 2006. 49. ‘The Role of Gemcitabine in the Adjuvant Treatment of Pancreatic Cancer’ and ‘Management of Brain Metastases: Concepts and Controversies’ – “Visiting Professor” at Norris Cancer Center and Department of Radiation Oncology as USC, Los Angeles, CA, August, 2006. 50. ‘Brain Metastases: Facts and Fiction’ – “Recrutiment Seminar” at The M.D. Anderson Cancer Center, Houston, TX, September, 2006. 51. ‘Management of Brain Metastases: Concepts and Controversies’ at Rocky Mountain Cancer Center, Casper Wyoming, September, 2006. 52. ‘Adjuvant Therapy for Pancreatic Cancer “Invited Speaker” at International Society of Gastrointestinal Oncology – The 2006 Gastrointestinal Oncology Conference, Arlington, VA, September, 2006. 53. ‘Management of Brain Metastases: Concepts and Controversies’ at Bay Medical Regional Cancer Center, Panama City, FL, October, 2006. 54. ‘Surgery, Radiosurgery, or Whole Brain Radiation Therapy for Brain Metastases: When & Why’ – “Visiting Professor” at Hahneman University, Department of Radiation Oncology, Philadelphia, PA, October, 2006.
William F. Regine, M.D. Curriculum Vitae - Page 33
55. ‘Management of Brain Metastases: Concepts and Controversies’ at St. Mary’s Medical Center, Huntington, West VA, October, 2006. 56. ‘Management of Brain Metastases: Concepts and Controversies’ at York Cancer Center, York, PA, October, 2006. 57. Low-Grade Gliomas, “Invited Speaker” at Management of Gliomas: A Case Based Approach, CME Symposium in conjunction with Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology, Philadelphia, PA, November, 2006.
58.
‘Management of Brain Metastases: Concepts and Controversies’ at Mt. Nittany Medical Center, College Park, PA, December, 2006.
59.
‘Glioblastoma Multiforme: The Multidisciplinary Approach to Treatment; and ‘Management of Brain Metastases: Concepts & Controversies’ “Visiting Professor” at the University of Florida/Shands Cancer Center and Department of Radiation Oncology, Gainesville, FL, December, 2006.
60.
‘Contemporary Management of Brain Metastases: ‘The Patricia Hunt Reynolds Memorial Lecture’ “Invited Speaker” at the Reading Hospital and Medical Center, Grand Rounds, West Reading, PA, April, 2007.
61.
‘Adjuvant Management of Pancreatic Carcinoma’ – “Visiting Professor”, Department of Radiation Oncology Grand Rounds, Henry Ford Health System, Detroit, Michigan, May, 2007.
62.
‘Malignant Gliomas, Hope & Life: Using Biology to Refine Treatment’ Grand Rounds and “Visiting Professor” at the University of Kentucky, Department of Radiation Medicine, Hematology Oncology and Neurosurgery, Lexington, KY, July, 2007.
63.
‘Malignant Gliomas, Hope & Life: Using Biology to Refine Treatment’ Grand Rounds and “Visiting Professor” at Vanderbilt University, Department of Radiation Oncology, Nashville, TN, August, 2007.
64.
‘Malignant Gliomas, Hope & Life: Using Biology to Refine Treatment’ Grand Rounds and “Visiting Professor” at the UPMC Cancer Center, Radiation Oncology Department, Philadelphia, PA, August, 2007.
65.
‘Malignant Gliomas, Hope & Life: Using Biology to Refine Treatment’ Grand Rounds and “Visiting Professor” at the Valley Hospital, Paramus, NJ, September, 2007.
66.
‘Malignant Gliomas, Hope & Life: Using Biology to Refine Treatment’ “Invited Speaker” at the Community Medical Center, Toms River, NJ, September, 2007.
67.
‘Malignant Gliomas, Hope & Life: Using Biology to Refine Treatment’ “Visiting Professor” and “Invited Speaker” at Virginia Commonwealth University, Massey Cancer Center, Richmond, VA, September, 2007.
68.
‘Malignant Gliomas, Hope & Life: Using Biology to Refine Treatment’ Grand Rounds and “Visiting Professor” at Rocky Mountain Cancer Center, Casper Wyoming, November, 2007.
69.
‘Malignant Gliomas, Hope & Life: Using Biology to Refine Treatment’ Grand Rounds and “Invited Speaker” at Prince William Hospital, Manassas, Virginia, November, 2007.
WORKS-IN-PROGRESS: 1.
Kwok Y, Suntharalingam M, Taylor R, Baig F, Yaes R, Mohiuddin M, Regine WF. A Definitive Evaluation of the Impact of Treatment Related Factors on Local Control in Patients with T1 Glottic Tumors Utilizing Linear-Quadratic Plus Time Model (Manuscript in Progress).
William F. Regine, M.D. Curriculum Vitae - Page 34
2.
Kudrimoti M, Arnold S, Valentino J, Spring P, Daniel K, Lee C, Pulmano C, Sloan D, Mohiuddin M, Regine WF. Changing Patterns of Failure in Advanced Stage Squamous Cell Carcinomas of the Head and Neck Treated with Hyperfractionated Radiation Therapy and Concurrent Intraarterial Cisplatin Injection (HYPERRADPLAT) (In progress).
3.
Kwok Y, Myrali, N, Chin L, Bangalore M, Amin P, Regine WF. Long-term Results of Gamma Knife Stereotactic Radiosurgery for Non-functioning Pituitary Adenomas (Manuscript in Progress).
4.
Dutta PR, Kwok Y, Herman JM, Chin L, Colliver C, St. Clair WH, Petit JH, Young B, Regine WF. Comparison of Repeat GK-STS for Refractory or Recurrent Trigeminal Neuralgia: Does Dose Matter? (Manuscript in Progress).
5.
Kudrimoti M, Mohiuddin M, Ahmed M, Meigooni AS, Hanna N, Regine WF. Use of high dose spatially fractionated radiation (GRID therapy) in management of large, poor prognostic Stage III (>10cms) soft tissue sarcomas (Manuscript in Progress).
6.
Patel S, Kwok Y, Shepard D, Chin L, Slawson R, Amin P, Regine WF. Evaluating the influence of dose-rate on outcome with gamma-knife stereotactic radiosurgery in the treatment of trigeminal neuralgia. (Manuscript in Progress).
7.
Dhople A, Kwok Y, Jaboin J, Sorkin JD, Slawson R, Amin P, Chin, L, Regine WF. Efficacy and Quality of Life in Patients with Atypical Facial Pain Treated with Gamma-Knife Stereotactic Radiosurgery. (Submitted JNS, May 2006).
8.
Garofalo MC, Malloy P, Amin P, Jaboin J, Gutt R, Regine WF. Treatment of Unresectable Chemorefractory Colorectal Liver Metastases with Selective Intrahepatic Application of Yttrium-90 Microspheres (SIR-Spheres): Early U.S. Experience. (Manuscript in Progress).
9.
Farrell J, Winter K, Rijnsoever MV, Regine WF, Abrams R, Safran H, Hoffman J, Schaeffer P, Mohiuddin M, Macdonald J, Bowen Benson A, Willett C, Elsaleh H. Thymidylate Synthase and Thymidine Phosphorylase: Protein Expression and Genotype in Pancreatic Cancer: Results from a prospective randomized adjuvant treatment trial. (In Progress).
10.
J Farrell, K Winter, M Van Rijnsoever, WF Regine, R Abram, H Safran, J Hoffman, P Schaeffer, M Mohiuddin, J Macdonald, A Bowen Benson, C Willett, H Elsaleh. Methylenetetrahydrofolate reductase. (MTHFR) polymorphism and pancreatic cancer: Results from a prospective randomized adjuvant treatment trial. (In Progress).
11.
J Farrell, K Winter, M Van Rijnsovever, WF Regine, R Abrams, H Safran, J Hoffman, P Schaeffer, M Mohiuddin, J Macdonald, A Bowen Benson, C Willett, H Elsaleh. Markers of Folate Metabolism in Pancreatic Cancer: Thymidylate Synthase, Thymidine Phosphorylase, and MTHFR. Results from the RTOG 9704 prospective randomized adjuvant treatment trial. (Accepted for Presentation at 2006 GI
William F. Regine, M.D. Curriculum Vitae - Page 35
ASCO meeting). 12.
Regine W, et al. Stereotactic Radiosurgery for Patients with Acoustic Tumors - Radiosurgery Practice Guideline Report # 2005-2. (Planned submission for Journal of Neurosurgery).
13.
Gaugler JE, Linder J, Given CW, Kataria R, Tucker, Regine WF. The Proliferation of Primary Cancer Caregiving Stress to Secondary Domains. (Planned Submission, August 2006).
14. Regine WF, Abrams RA. Adjuvant Therapy for Pancreatic Cancer: Current Status, Future Directions. (Accepted, Seminars in Oncology, September 2006). 15.
Gaugler JE, Linder J, Given CW, Kataria R, Tucker G, Regine WF. Variations in the Stress Process Among African-American and Caucasian Cancer Caregivers. (Planned Submission October 2006).
16.
Berger A, Winter K, Hoffman J, Regine WF, Abrams R, Safran H, Konski A, Benson A, MacDonald J, Willett C. Post-Resection CA 19-9 Predicts Overall Survival in Patients Treated with Adjuvant Chemoradiation â&#x20AC;&#x201C; A Secondary of RTOG 9704. (Submitted for 2007 ASCO meeting).
17. Gaugler JE, Given CW, Linder J, Kataria R, Tucker G, Regine WF. Work, Gender, and Stress in Cancer Caregiving. (Planned Submission). 18. Farrell J, Garcia M, Lai R, Ammar A, Regine WF, Abrams RA, Benson B, Macdonald J, Cass CE, Elsaleh H, Mackey J. Human ENT1 is predictive of response in ptaients with pancreatic cancer treated with gemcitabine: Results from the RTOG 9704 Prospective Randomized Trial. (Accepted for May 2007 Digestive Disease Week). 19. Farrell J, Garcia M, Ammar A, Regine WF, Abrams RA, Benson B, Macdonald J, Schaefer P, Elsaleh H. Ribonulceotide Reductase Single Nucleotide Polymorphisms: Markers of Response to gemcitabine in Prospective Pancreatic Cancer Treatment Trial RTOG 9704. (Accepted for May 2007 Digestive Disease Week).
William F. Regine, M.D. Curriculum Vitae - Page 36
20. Dhople A, Kwok Y, Chin L, Shepard D, Slawson R, Amin P, Regine WF. Efficacy and Quality of Life Outcomes in Patients with Atypical Trigeminal Neuralgia Treated with Gamma-Knife Radisurgery. (Submitted for ASTRO Annual Meeting, 2007). 21. Adams JR, Dhople A, Kwok Y, Yu C, Simard JM, Maggio W, Regine WF. Long Term Follow-up of Gamma Knife Stereotactic Radiosurgery for Trigeminal Neuralgia. (Submitted for ASTRO Annual Meeting, 2007). 22.
Regine WF, Garcia M, Berger AC, Abrams RA, Safran H, Konski A, Benson AB, MacDonald JS, Rich TA, Willett CG. Post-Resectional CA 19-9 Values > 90 Are Associated with Significantly Worse Survival In Patients with Pancreatic Carcinoma Treated with Adjuvant Therapy on RTOG 9704-Implications for Current and Future Trials. (Submitteed for ASTRO Annual Meeting, 2007).
24. Ekbk M, Wang JZ, Regine WF. The effect of docetaxel (Taxotere®) on Human Gastric Cancer Cells Exhibiting Low-Dose Radiation Hypersensitivity. (Accepted, December 2007 - Clinical Medical Oncology). 25. The Effect of Dose-Rate on the Efficacy of Gamma-Knife stereotactic Radiosurgery in Patients with Trigeminal Neuralgia. (Submitted to Neurosurgery Focus). 26. Repeat Gamma-Knife Stereotactic Radiosurgery for Refractory or Recurrent Trigeminal Neuralgia: An Argument for 90 Gy Repeat Dose. (Submitted to Neurosurgery Focus). 27. Berger Adam C, Garcia M, Regine WF, Abrams R, Safran H, Hoffman J, Benson Al, Macdnald J, Willett J. Increasing Lymph Node Ratio (LNR) Significantly Decreases Survival in Patients Undergoing Pancreaticoduodenectom (PD) Followed by Adjuvant Chemoradiation (CRT) for Pancreatic Cancer – A Secondary Analysis of RTOG 9704. (Submitted for presentation at 2008 ASCO Gastrointestinal Cancers Symposium). 28. Gaugler JE, Linder J, Given CW, Kataria R, Tucker G, Regine WF. Cancer Caregiving and Wel-Being: The Direct and Mediational Effects of Psychosocial Resources. (Submitted for publiciation in PsychoOncology). ONGOING INVESTIGATIONAL STUDIES/GRANT SUPPORT: INSTITUTIONAL
William F. Regine, M.D. Curriculum Vitae - Page 37
1.
Phase I study of combined fractionated stereotactic radiosurgery and conventional external beamirradiation in the treatment of intracranial tumors [ Principal Investigator ] – Unfunded – 1994 – 2003.
2.
Paclitaxel, carboplatin and radiotherapy as induction therapy in advanced head and neck cancer [ Co–Investigator ] –$Funded Study – 9/00-4/02 - $90,000 (Total)
3.
An open label phase I study of TNF-alpha gene therapy with radiation therapy for locally advanced, recurrent, or metastatic solid tumors [ Co-Investigator ] - $Funded Study – 10/00-10/01 - $180,349 ( Total).
4.
An open-label, dose-esclation study of TNFeradeTM biologic with radiation therapy as an adjunct to surgery or for palliation in soft tissue sarcoma of the extremities [ Co-Investigator ] $Funded Study - 1/02-12/03 $93,210 ( Total).
5.
The effect of cancer on the cancer patient caregiver [ Co-Investigator ] – $Funded Pilot Study ( ACS – 10K ) – 2001-2002.
6.
Phase I/II evaluation of radiation and gemcitabine in locally advanced or metastatic tumors of the gastrointestinal tract [ Principal Investigator ] – $Funded Study – 7/99-12/00 - $48,010 (Total): $38,111(Direct) + $9,899 (Indirect) – sponsor – Eli Lilly.
7.
A multinational, multicenter, double-blind, placebo-controlled, randomized, phase III clinical trial to determine the efficacy and safety of IB-367 rinse in reducing the severity of oral mucositis in patients receiving radiotherapy for head and neck malignancy [ Institutional Principal Investigator ] - $Funded Study – 9/00-6/02 - $136,895 (Total): $107,360 (Direct) + $29,535 (Indirect) – Sponsor – Pharmanet Inc.
8.
Radiation Therapy Oncology Group Studies [ Institutional – Full Member – Principal Investigator ] $Funded Study – 8/96-12/02 - $284,433 (Total): $247,638 (Direct) + $36,795 (Indirect) – Sponsor – American College of Radiology.
9.
A Phase I Study of Low-Dose Upper Abdominal Radiation Therapy (UART) or Whole (W) ART as a Chemosensitizer in Patients with Locally Advanced or Metastatic Tumors of the Gastrointestinal Tract or Ovary [ Prinicipal Investigator ] - $ Funded Study – 11/00-11/02 - $19,700 (Total): $15,641 (Direct) = $4,059 (Indirect) – Sponsor – Eli Lilly.
10.
Families and Cancer: Stress, Resources, and Outcomes [ Co-Investigator ] - $Funded Pilot Study ((Institutional – 15K ) – 2002-2003.
11.
Cancer caregiving and the stress process. Submitted May 2002 for RFA for funding ( 100 K ) by Small Grants Program for Behavioral Research in Cancer Control [ Co-Investigator ]
12.
Compreshensive support for Breast Cancer Caregivers. Submitted Jun 2002 for funding ( 425K ) by US Department of Defense [ Co-Investigator ]
13.
A Phase I/II Study of Low-Dose Upper Abdominal Radiation Therapy (UART) or Whole (W) ART as a Chemosensitizer in Patients with Locally Advanced or Metastatic Tumors of the Gastrointestinal Tract or Ovary [ Prinicipal Investigator ] - $ Funded Study – 10/03-03/06 - $213,000 (Total): $170,800 (Direct) = $42,700.00 (Indirect) – Sponsor – Eli Lilly.
14.
Master Research Agreement – Varian Medical Systems. $Funded study – 4/06 – 4/11 - $1.25M (Total) [CoInvestigator].
William F. Regine, M.D. Curriculum Vitae - Page 38
NATIONAL 1.
A phase III postoperative adjuvant protocol for pancreatic adenocarcinoma. Intergroup/RTOG protocol #97-04 [ Principal Investigator/Study Chairman ] – Activated 7198; closed 7/02.
2.
A feasibility study of neurocognitive evaluation in patients treated for brain metastases. RTOG Protocol #BR-0018 [ Principal Investigator/Study Chairman ] – Activated
3.
A Phase II trial of conventional radiation therapy followed by intratumoral bleomycin delivered using a refillable, sustained release device (IND# 46,592) for the treatment of supratentorial glioblastoma. RTOG Protocol #BR-0013 [ Study Co-Chairman ] - Activated
4.
A Phase I/II Postoperative Adjuvant Therapy with Gemcitabine and Gemcitabine and Irradiation Following Pancreaticoduodenectomy for Pancreatic Adenocarcinoma Resected with Curative Intent. RTOG Protocol #0414 [Study Co-Chairman]
TEACHING/ EDUCATION EXPERIENCE: INSTITUTIONAL Medical Student Education - Monthly lecture to senior students in radiology elective; Section of Radiation Oncology, University of Tennessee, Memphis, Tennessee 1992 – 1994 Medical Student Education – Preceptor for students rotating through department, 1994 – present (~ 2/ year) University Hospital Tumor Board - Biannual presentation/lecture in clinical radiation oncology, 1992 - 2001 Radiation Oncology Resident Education a) Annual lectures in clinical radiation oncology, 1994 – present ( ~ 6 students) b) Annual lecture in radiation biology, 1996, 1998, 1999 c) Morning quality assurance/teaching conference ( 3-5 X’s/week ), 1994 – present ( ~ 12 students) d) Monthly journal club, 1994 – present ( ~ 6 students) e) Quarterly morbidity and mortality conference, 1994 – present ( ~ 6 students) f) Oral Mock Boards (quarterly), 1997 – present ( ~ 4 students) Radiation Therapy Student Education - Annual lectures in clinical radiation oncology, 1994 – 2002 (~ 6 students) Medical Physics Student Education - Annual lectures in clinical radiation oncology, 1994 – 2001
William F. Regine, M.D. Curriculum Vitae - Page 39
(~ 6 students) Hematology – Oncology Fellow Education – Preceptor for fellows rotating through department, 1994 – 2002 ( 1/ year) and annual lectures (2006) Neurosurgery Resident Education - Grand Rounds/Annual lecture in clinical radiation oncology, 1995 – 2002 ( ~ 10 students) Gamma Knife Radiosurgery/Neuro-Oncology Conference - Weekly, 1996 - present Neuroradiology Conference - Weekly, 1994 – 2002 E.N.T. Resident Education - Annual lecture in clinical radiation oncology, 1995 – 2002 ( ~ 6 students) Multidisciplinary Head and Neck Cancer Conference - Weekly, 1994 – 2002 ( ~ 10 students) Multidisciplinary Gastrointestinal Conference - Weekly, 1996 – present ( ~ 10 students) Ophthalmology Resident Education - Lecture in clinical radiation oncology, 1995 Radiation Therapist Education - Lecturer in University of Kentucky Radiation Therapist Seminar Series, 1997 Neurology Resident Education - Grand Rounds - lecture in clinical radiation oncology, 1997
William F. Regine, M.D. Curriculum Vitae - Page 40
Surgery Resident Education - Head and Neck Working Group and Head and Neck Skills Course Co-Instructer in developing and implementation ofstructured clinical instruction module for head and neck cancer - Radiation Therapy Section, 1997 St. Claire Medical Center Tumor Board – Bi-Monthly, 1997 – 2002 Oral Examiner for Institutional Medical Physics Masters Degree Program - 1996 - 2002 Sponsor of Resident Research – Mihoko Fugita, MD, PhD – Second Malignant Neoplasia in Patients with T1 Glottic Cancer Treated with Radiation (Manuscript Published) - 1997 Sponsor of Medical Student Research – Eugene S. Gamburg, MS III – The Prognostic Significance of Midline Shift on Survival of Patients Presenting with Glioblastoma Multiforme (Presented at National Meeting and Manuscript Published) – 1998-1999 Sponsor of Resident Research – Jennifer Huhn, DO – Gamma Knife Radiosurgery Alone Following High Resolution MRI in Patients with Newly Diagnosed Brain Metastases: Results and Implications (Presented at National meeting and Manuscript Published) – 1999 Sponsor of Resident Research - Anil Dhople, MD – Gamma Knife Radiosurgery for Atypical Trigeminal Neuralgia (Presented at National Meeting and Paper in Press) – 2005 Sponsor of Resident Research - Todd Flannery, MD – The Impact of Definitive Thoracic Management in Paitents with Singlew Brain Metastasis Treated with Raidosurgery (Presented at National Meeting paper in development, and published paper). Dental Residents – Lecture in use of Gamma Knife for Trigeminal Neuralgia – 2000 Sponsor of Medical Student Research – T. Brady Reid, MS II – Safety and Efficacy of Utilizing 20Gy Target Dose Gamma Knife Radiosurgery for Metastatic Brain Tumors with a Maxiumum Volume of 5 cc (Presented as Finalist at 2001 University of Kentucky Alpha Omega Alpha Student Research Day published) – 2000-2001 Sponsor of Visiting Physician Research – Anna Rogosinska, MD – Prognostic Factors in Patients with Resected Single Brain Metastases: Evaluation of Recursive Partitioning Analysis (RPA) Classes I and II (Presented at National meeting and manuscript submitted for publication) – 2001 - 2002 Sponsor of Medical Student Research – Michael Shehata, MS III – Gamma Knife Radiosurgery for Metastatic Brain Tumors with a Maxiumum Volume of 5 cc - The University of Kentucky Experience –(Presented at National meeting and manuscript in progress) 2001-Present.
William F. Regine, M.D. Curriculum Vitae - Page 41
Sponsor of Medical Student Research - Alice Cheuk, MS IV – Imaging Correlates of Gamma Knife Outcome in Trigeminal Neuralgia (submitted to ASTRO 2004 and IRJOBP, February 2004) – 2003-2004. Sponsor of Medical Student Research - Pinaki Dutta, MS IV – Results of Repeat Gamma Knife Radiosurgery for Retractory or Recurrent Trigeminal Neuralgia (submitted ASTRO 2004) – 2003-2004. E.N.T. Resident Education – Preceptor for residents rotating through department, 2002. Nurse Practitioner Student Education – Lecture on Head & Neck Cancer (~ 10 students), 2003. Medical Dosimetrist Student Education – Annual lectures in clinical radiation oncology, ( ~ 2 students), 2003. Course Director – “New Trends in the Management of Trigeminal Neuralgia”, University of Maryland Medical System – CME – 2003 – 2005. “Gamma Radiosurgery for Trigeminal Neuralgia”, University of Maryland Medical System CME: Current Management of Trigeminal Neuralgia, Greater Baltimore Medical Center Hospital, Trigeminal Neuralogic Support Group Baltimore, MD, December, 2003. “Gamma Radiosurgery for Trigeminal Neuralgia”, University of Maryland Medical System CME: Current Management of Trigeminal Neuralgia, Bethesda, MD, January 2004. “Gamma Radiosurgery for Trigeminal Neuralgia”, Unversity of Maryland Medical System CME: Current Management of Trigeminal Neuraligia, Annapolis, MD, March 2004. “Gamma Radiosurgery for Trigeminal Neuralgia”, and “Surgical Management for Trigeminal Neuralgia” University of Maryland Medical System CME: Current Management of Trigeminal Neuraligia, Cambridge, MD, October 2004. “Surgical Management for Trigeminal Neuralgia”, University of Maryland Medical System CME: Current Management of Trigeminal Neuralgia, Holy Cross Hospital, Silver Spring, MD, November 2004. “Gamma Radiosurgery for Trigeminal Neuralgia”, University of Maryland Medical System CME: Current Management of Trigeminal Neuralgia, Holy Cross Hospital, Silver Spring, MD, November 2004.
William F. Regine, M.D. Curriculum Vitae - Page 42
“Gamma Radiosurgery for Trigeminal Neuralgia”, University of Maryland Medical System CME: Current Management of Trigeminal Neuralgia, Valley Dental Society meeting, Pikesville, MD January 2005. “State-of-the-Art Treatment Approaches for Brain Metastases” – “Invited Speaker” at Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, March, 2005. “Malignant Gliomas: Impacting survival with New Treatment Strategies: - “Invited Speaker” – at Marlene and Stewart Greenebaum Cancer Center, April, 2005. “Use of Gamma Knife Radiosurgery for Brain Tumors”, - “Invited Speaker” at Marlene and Stewart Greenebaum Cancer Center, January, 2006. Course Director – “Annual Mid-Atlantic ASTRO Review”, University of Maryland School of Medicine – CME – 2005 to present. Panel Discussant – “The Changing Approach to High-Grade Glioma Treatment”, CME Symposium in Conjunction with the American Association of Neurological Surgeons Annual Meeting, San Francisco, CA, April 2006. “Adjuvant Postoperative Chemoradiation for Pancreatic Cancer: Where We Have Been and Where Are We Going” - Invited Speaker Hematology/Oncology Grand Rounds, University of Maryland Marlene and Stewart Greenebaum Cancer Center, Baltimore, MD, January, 2007. NATIONAL American Board of Radiology Examiner in Radiation Oncology – Oral Exam – 1998 - Present American Board of Radiology Examiner in Radiation Oncology – Written Exam – 2000 – Present Radiation Therapy Oncology Group New Invesitgators Committee (G.I. Cancer) – 2004 - Present “Meet the Professor Luncheon at 46th Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology – 2004, 2006 Metastatic Brain Tumor – Concepts and Controversies: A Roundtable Discussion – Mehta MP, Gilbert MR, Lassman AB, Regine WF, Stieber VW. CME/CE accredited Grand Rounds program on Metastatic brain cancer, 2006. The Gastrointestinal Cancers Symposium, (Sponsored by ASCO, ASTRO & SSO) Program Committee – Member 2007 – present. The Gastrointestinal Cancers Symposium - Cancers of the Pancreas, Small Bowel and Hepatobiliary Tract Subcommittee member – 2007 – present.
William F. Regine, M.D. Curriculum Vitae - Page 43
REVIEW / EDITORIAL POSITIONS: 1994 - present
Reviewer, International Journal of Radiation Oncology-Biology-Physics
1994 - present
Reviewer, Cancer
1996 - present
Reviewer, Journal of Clinical Oncology
1998 - present
Reviewer, Journal of Neuro-Oncology
2001 – present
Reviewer, Critical Reviews in Oncology/Hematology
2001 – 2002
Reviewer, Head & Neck
2002 – present
Reviewer, Annals of Surgical Oncology
2001 – present
Board of Editors, Technology in Cancer Research and Treatment
2003 – 2006
Board of Editors, American Journal of Clinical Oncology
William F. Regine, M.D. Curriculum Vitae - Page 44
2007 – present
Reviewer, Nature Clinical Practice Gastroenterology & Hepatology
2008 – present
Board of Editors, Journal of Clinical Oncology
ADMINISTRATIVE EXPERIENCE / POSITIONS: INSTITUTIONAL 1992 – 1994
Coordinator of Departmental Medical Student Rotations, Section of Radiation Oncology, University of Tennessee, Memphis, Tennessee
1994
Acting Clinical Chief, Section of Radiation Oncology, University of Tennessee, Memphis, Tennessee
1994 – 2002
Coordinator of Departmental Hematology-Oncology Fellow Rotations
1994 – 2002
Departmental Clinical Research Coordinator
1994 – 1995
Member of Departmental Quality Assurance Committee
1995 – 1998
Member of Institutional Gastrointestinal Oncology Clinic Planning Committee
1996 – 1998
Member of Institutional Scientific Advisory Committee
1996 – 1998
Member of Institutional Gamma Knife Radiosurgery Business Planning
Committee
William F. Regine, M.D. Curriculum Vitae - Page 45
1996 – 1998
Member of Institutional Lung Cancer Business Planning Committee
1996 – 1998
Member of Institutional Gastrointestinal Cancer Business Planning Committee
1996 – 2002
Member of Institutional Gastrointestinal Tumor Site Committee
1996 – 2002
Member of Institutional Central Nervous System Tumor Site Committee
1996 – 2002
Coordinator of Institutional Head & Neck Tumor Site Committee
1997 – 2000
Member of Institutional Oncology Advisory Committee
1997 – 1999
Member of Kentucky Medical Services Foundation Faculty Advisory Committee
1997
Participant in University of Kentucky Executive Development Program for Physicians
1997 – 2002
Alternate Member/Representative from Department of Radiation Medicine for Institutional Council of Chairs
1998 – 2002
Member of Markey Cancer Center Protocol Review and Monitoring System Committee
1998 – 2002
Institutional Principal Investigator for Radiation Therapy Oncology Group
William F. Regine, M.D. Curriculum Vitae - Page 46
1998 – 1999
Member of Institutional Associate Chiefs of Clinical Affairs Committee
1998 – 2002
Member of Institutional Tumor Registry Audit Group
1998 – 2000
Medical Director of Clinical Research Office, Markey Cancer Center, University of Kentucky
1998 – 2000
Member of Institutional Ocular & Orbital Tumors Regional Center Business Planning Committee
1998 – 1999
Member of Institutional Cancer Center Clinical Coordinating Committee
1998 – 2002
Member of Institutional Advisory Committee for Clinical Research and Investigator Services
1998 – 1999
Member of Institutional Educational Review Committee for Department of Diagnostic Radiology
1999 – 2002
Member of St. Agnes House ( Community Patient Housing Facility ) Board of Management
1999 – 2002
Member of St. Agnes House ( Community Patient Housing Facility ) Board of Management Fundraising Committee
1999 – 2002
Member of Departmental Billing Procedures Review Committee
William F. Regine, M.D. Curriculum Vitae - Page 47
1999 – 2002
Institutional Alternate Member/Representative for the Association of Community Cancer Centers
1999 – 2000
Member of Institutional Educational Review Committee for Department of Radiation Medicine
1999 – 2000
Director, University of Kentucky Gastrointestinal Oncology Program
1999 – 2000
Member of Institutional Clinical Research Activities Working Group
2000 – 2002
Departmental Representative for University Physicians Governing Board
2000 – 2002
Vice-President of St. Agnes House ( Community Patient Housing Facility ) Board of Management
2000 – 2002
Chairman Departmental Clinical Research Committee
2000 – 2002
Institutional Member VA Oncology Research Network
2000 – 2002
Departmental Manager of Nursing
2000 – 2002
Departmental Manager of Research Associates
William F. Regine, M.D. Curriculum Vitae - Page 48
2000 – 2002 2001 – 2002
Member of St. Agnes House (Community Patient Housing Facility) Board Long Range Planning Committee Member of University Physicians Strategic Task Force
2001 – 2002
Member of Institutional Radioactive Drug Research Committee
2001
Member of Insitutional Educational Review Committee for Department of Obstetrics and Gynecology
2001 – 2002
Member of Institutional Head and Neck Cancer Clinical Care and Research Team
2001 – 2002
Director of Institutional Gastrointestinal Cancer Clinical Care and Research Team
2001 – 2002
Member of Institutional Central Nervous System Cancer Clinical Care and Research Team
2001 – 2002
Member of Instutional Strategic Task Force – Focused on Improvement in Payer Mix
2001 – 2002 2001 – 2002
Chairman of Departmental Clinical Operations Committee Chairman of Departmental Quality Assurance Committee
2002
Member of Institutional Task Force Reviewing Faculty Salaries
2002
Member of Institutional Clincal Affairs Committee, Markey Cancer Center
2002
Coordinator of Departmental E.N.T. Resident Rotations
William F. Regine, M.D. Curriculum Vitae - Page 49
2002
Member of Markey Cancer Center Clinical Practices Task Force
2002
President of St. Agnes House ( Community Patient Housing Facility ) Board of Management
2002
Member of Institutional Neurosciences Business Planning Committee
2004 - present
Member of Institutional Clinical Affairs Advisory Committee
2004
Baltimore Area Council, Boy Scouts of America, Health Services Leadership Awards Luncheon, Event Committee Member
2005 - present
Member of Cancer Center Clinical Research Oversight Committee
2005
Member of Institutional Educational Review Committee for Nephrology Program
2005 – present
Member of Technology Research Review Committee
2005 – present
Member of Ambulatory Care Center Project Operations Committee
2006 - present
Member of University Physicians Incorporated Compliance Committee
2006 – present
Member of Appointment, Promotion, and Tenure Committee
William F. Regine, M.D. Curriculum Vitae - Page 50
2006
Member of Institutional Committee Developing Orientation Manual for New Chairs and Administrators
2007
Member of Institutional Educational Review Committee for Neuroradiology Program NATIONAL
1994
National Cancer Institute Ad Hoc Reviewer for grants and contracts
1998 – 2002
Member of Radiation Therapy Oncology Group Full Member Principal Investigator Committee
1998 – 2002
Member of Radiation Therapy Oncology Group Head and Neck Cancer Steering Committee
1998 – 1999
Member of National Cancer Institute Gastrointestinal Cancer Strategy Committee
1998 – present
Member of Radiation Therapy Oncology Group Gastrointestinal Cancer Steering Committee
William F. Regine, M.D. Curriculum Vitae - Page 51
1999 – present
Member of Radiation Therapy Oncology Group Central Nervous System Cancer Steering Committee
2001 – present
Member of Radiation Therapy Oncology Group Central Nervous System Cancer Steering Committee – Brain Metastases Working Group/Subcommittee
2001 – 2002
Member of Patterns of Care Study Committee on CNS – Role of Radiosurgery in Brain Metastases
2002 – 2004
Secretary/Treasurer for The Simon Kramer Society
2003 – present
Member of Genvec Data Safety Monitoring Board
2003
Member of RTOG Review Committee for proposes NCI Common Toxicity Criteria – Greenebaum Cancer Center, Baltimore, MD, March, 2005. Version 3
2004
Member of External Advisory Board for Wake Forest/Ed Shaw (PI) PO-1 Application – “The RAS and Radiation Induced Brain Injury”
2005
Chairman – Image Guided Radiotherapy Session, Varian Medical Systems RT 2010 meeting – Las Vegas, NV – January, 2005
2005
Vice-President/President Elect for The Simon Kramer Society
2005
Member of ASTRO Committee Responding to Neurosurgery Request to NRC for Gamma Knife Exemption
2006 - present
President for The Simon Kramer Society
William F. Regine, M.D. Curriculum Vitae - Page 52
2006 – present
Member of ACR Radiation Oncology Rectal/Anal Expert Panel
2006 – present
Member of U.S. Intergroup Hepatobiliary Cancer Clinical Trials Task Force
2007 – present
Member of U.S. Intergroup Pancreatic Cancer Clinical Trials Task Force
2007
Co-Chaired Radiation Therapy Oncology Group Gastrointestinal Cancer Steering Committee
2007 – present
Member of ASCO GI Cancer Symposium Steering Committee INTERNATIONAL
2001
Chairman CNS Committee – Late Effects Normal Tissues IV NCI sponsored Workshop
2004
Co-Chairman of 2nd Annual 3D Line User Meeting. 3D Line Medical Systems. Atlanta, GA, October, 2004.
2005
Co-Chairman and Panel member – Pancreatic Cancer Session – International Society of Gastrointestinal Oncology – The 2005 Gastrointestinal Oncology Conference, Arlington, VA, July, 2005.
2006
Co-Chairman and Panel member – Pancreatic Cancer Session – International Society of Gastrointestinal Oncology – The 2006 Gastrointestinal Oncology Conference, Arlington, VA, September, 2006
2007
Protocol Reviewer (Proposed Phase III Locally Advanced Pancreas Trial) for European Study Group for Pancreatic Cancer, (ESPAC) Trials Advisory Committee