CURRICULUM VITAE Todd Denton Gould, M.D. Assistant Professor Department of Psychiatry University of Maryland School of Medicine Date January 26, 2013 Personal Information Mood and Anxiety Disorders Program 701 West Pratt Street, Suite 388 Baltimore, MD 21201 Phone: (410) 706-2323 E-mail: tgould@psych.umaryland.edu Education 1996 2001
B.S., Biology/Chemistry, Lock Haven University M.D., University of Virginia School of Medicine
Post-Graduate Education and Training 1996-1997 Predoctoral Fellow Laboratory of Mammalian Genes and Development-Unit on Genomic Imprinting, NICHD, NIH, Bethesda, MD 2000
Clinical Research Elective Fellow Child Psychiatry Branch, NIMH, NIH, Bethesda, MD
2001-2006
Postdoctoral Fellow (also Eli Lilly/NIMH Neuroscience Research Fellow & NIMH Seymour S. Kety Memorial Fellow) Laboratory of Molecular Pathophysiology and Experimental Therapeutics, NIMH, NIH, Bethesda, MD
2006-2007
Research Fellow Laboratory of Molecular Pathophysiology and Experimental Therapeutics NIMH, NIH, Bethesda, MD
Post-Graduate Education and Training 2007 Assistant Professor of Psychiatry University of Maryland School of Medicine Professional Memberships 2001 Society for Neuroscience 2001 American Association for the Advancement of Science
Curriculum Vitae, Todd D. Gould
2002 2006
Society of Biological Psychiatry International Behavioral Neuroscience Society
Honors and Awards 1995 National Science Foundation Summer Training Fellowship (Thomas Jefferson University, Department of Biochemistry and Molecular Biology) 1996 NIH Predoctoral Intramural Research Training Award 1998 University of Virginia School of Medicine Summer Research Program Fellowship 2001 NIH Postdoctoral Intramural Research Training Award 2003 Lilly Fellowship Award (travel award for the Society of Biological Psychiatry (SOBP) annual meeting) 2003 Eli Lilly/NIMH Neuroscience Research Fellowship 2003 NIMH Seymour S. Kety Memorial Fellowship Training Award 2004 NIH Fellows Award for Research Excellence (travel award); Neuropharmacology/Neurochemistry study section 2004 Collegium Internationale Neuro-Psychopharmacologicum (CINP) Young Investigator Rafaelsen Scholar Award (travel award) 2004 Selected to attend the Research Career Development Institute in Psychiatry (sponsored by University of Pittsburgh, Western Psychiatric Institute and Clinic, and Stanford University) 2004 National Alliance for Research on Schizophrenia and Depression (NARSAD) Young Investigator Award 2004 Research Career Development Institute in Psychiatry American College of Neuropsychopharmacology (ACNP) travel award 2005 NIH Fellows Award for Research Excellence (travel award); Neurology, neuroimmunology, and neuropharmacology/neurochemistry study section 2005 American College of Neuropsychopharmacology (ACNP) Young Investigator Memorial Travel Award 2006 International Behavioral Neuroscience Society (IBNS) Travel Award Administrative Service Institutional Service 2004-2007 CME/CE Activity Directory, Neurobiology of Mental Illness 14-week course, Foundation for Advanced Education in Science, NIH campus 2004 Judge, NIH Fellows Award for Research Excellence, Psychiatry and Behavioral/Social Sciences Study Section, intramural NIH 2005 Judge, NIH Fellows Award for Research Excellence, NeuroscienceNeurogenetics and Development Study Section, intramural NIH National Service Conference Committees 2006 Organizing committee, Role of CINP in Supporting New Investigators in Neuropsychopharmacology symposium; Collegium Internationale NeuroPsychopharmacologicum (CINP) meeting, Chicago, IL
Page number 2
Curriculum Vitae, Todd D. Gould
2005 2006 2006
Conference Symposium Chair Co-Chair, Bipolar Disorder Endophenotypes symposium; Society of Biological Psychiatry (SOBP) annual meeting, Atlanta, GA Co-Chair, Animal Models for Bipolar Disorder; Novel Basic and Translational Approaches mini symposium; Society of Biological Psychiatry (SOBP) annual meeting, Toronto, Ontario Co-Chair, Research Funding in Neuropsychopharmacology symposium, Collegium Internationale Neuro-Psychopharmacologicum (CINP) young investigator event, Chicago, IL Journal Manuscript Review American Journal of Medical Genetics: Neuropsychiatric Genetics, American Journal of Psychiatry, Archives of General Psychiatry, Behavioral Genetics, Biological Psychiatry, Bipolar Disorders, BMC Biochemistry, CNS Drugs, The FASEB Journal, International Clinical Psychopharmacology, International Journal of Neuropsychopharmacology, Journal of Cell Science, Journal of Clinical Psychiatry, Journal of Neurochemistry, Journal of Neurodegeneration and Regeneration, Journal of Neuroscience, Journal of Pharmacology and Experimental Therapeutics, Journal of Psychiatric Research, Medicinal Research Reviews, Neuropsychopharmacology, Neuroscience & Biobehavioral Reviews, Neuroscience Letters, Progress in NeuroPsychopharmacology & Biological Psychiatry, Psychopharmacology, Science, Trends in the Pharmacological Sciences Grant Review
2004 2005 2005 2006 2006 2006 2006 2007
Swiss National Science Foundation NIH Synthetic and Biological Chemistry Study Section (Adhoc) NIH Molecular, Cellular, and Developmental Neuroscience Integrated Review Group (Adhoc) The Welcome Trust Department of Defense Congressionally Directed Peer-Reviewed Medical Research Program (CDMRP-PRMRP) The Royal Society, London Ontario Mental Health Foundation Research Grants Council, Hong Kong
Editorial Responsibilities 2006-present Editorial Board, Journal of Neurodegeneration and Regeneration 2007 Guest Editor, Neuroscience and Biobehavioral Reviews special issue: Animal Models of Bipolar Disorder and Mood Stabilizer Efficacy Teaching Service Graduate Teaching
Page number 3
Curriculum Vitae, Todd D. Gould
2002-2007 2002-2007 2005 Mentoring Koshy Thomas Allysa Picchini Kelley O’Donnell Eliot Dow
Faculty, Co-Founder and Co-Director of course, Neurobiology of Mental Illness (BIOL 435M), Foundation for the Advanced Education in the Sciences (FAES; graduate school on NIH campus); ~ 80 students/year Lecturer, ‘Neurobiology of Major Depression’, Neurobiology of Mental Illness (BIOL 435M), NIH FAES Lecturer, ‘The Neurobiology of Depression’, Pathophysiology graduate course (PBIO 603), Georgetown University, Department of Physiology 2003, NIH Undergraduate Summer Intramural Research Training Award Fellow; ‘Effect of lithium and valproate on protein levels of GSK-3 targets’ 2004-2005, NIH Post-Baccalaureate Intramural Research Training Award Fellow; ‘Gene array study analysis of β-catenin transgenic mice’ 2005-2007, NIH Post-Baccalaureate Intramural Research Training Award Fellow; ‘Behavioral analysis of β-catenin KO mice’ 2006-2007, NIH Undergraduate Intramural Research Training Award Fellow; ‘Analysis of β-catenin/bcl-2 protein-protein interactions’
Grant Support Title: Glycogen Synthase Kinase-3: a novel target for the development of new treatments for bipolar disorder?, Principle Investigator, National Association for Research on Schizophrenia and Depression (NARSAD), Grant Period: 7/1/04-6/30/06. Annual direct cost: $30,000; Total cost: $60,000 Publications Peer Reviewed Articles 1) Gould TD and Pfeifer K (1998) Imprinting of mouse Kvlqt1 is developmentally regulated. Human Molecular Genetics. 7, 483-487. 2) Gould TD, Bastain TM, Israel ME, Hommer DW, Castellanos FX (2001) Altered performance on an ocular fixation task in attention-deficit/hyperactivity disorder. Biological Psychiatry. 50, 633-635. 3) Lenox RH, Gould TD, Manji HK (2002) Endophenotypes in bipolar disorder. American Journal of Medical Genetics: Neuropsychiatrics Genetics. 114, 391-406 [Erratum in: Am J Med Genet (2002) 114, 592]. 4) Gould TD and Manji HK (2002) The Wnt signaling pathway in bipolar disorder. The Neuroscientist. 8, 497-511. 5) Gould TD and Manji HK (2002) Signaling pathways in the pathophysiology of mood disorders. Journal of Psychosomatic Research. 53, 687-697. 6) Gould TD, Chen G, Manji HK (2002) Mood stabilizer psychopharmacology. Clinical
Page number 4
Curriculum Vitae, Todd D. Gould
Neuroscience Research. 2, 193-212. 7) Gottesman II and Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. The American Journal of Psychiatry. 160, 636-645. 8) Manji HK, Gottesman II, Gould TD (2003) Signal transduction and genes-to-behaviors pathways in psychiatric diseases. Science STKE. Pe49. 9) Einat H, Manji HK, Gould TD, Du J, Chen G (2003) Possible involvement of the ERK signaling cascade in bipolar disorder: behavioral leads from the study of mutant mice. Drug News & Perspectives. 16, 453-463. 10) Li J, Gould TD, Yuan P, Manji HK, Chen G (2003) Post-mortem interval effects on the phosphorylation of signaling proteins. Neuropsychopharmacology. 28, 1017-1025 [Erratum in: Neuropsychopharmacology (2003) 28, 1219]. 11) Gould TD, Gray NA, Manji HK (2003) Effects of a glycogen synthase kinase-3 inhibitor, lithium, in adenomatous polyposis coli mutant mice. Pharmacological Research. 48, 49-53. 12) Einat H, Yuan P, Gould TD, Li J, Du J, Zhang L, Manji HK, Chen G (2003) The role of the extracellular signal-regulated kinase signaling pathway in mood-modulation. The Journal of Neuroscience. 23, 7311-7316. 13) Gould TD, Chen G, Manji HK (2004) In vivo evidence in the brain for lithium inhibition of glycogen synthase kinase-3. Neuropsychopharmacology. 29, 32-38. 14) Gould TD, Zarate CA, Manji HK (2004) Glycogen synthase kinase-3: a target for novel bipolar disorder treatments. Journal of Clinical Psychiatry. 65, 10-21. 15) Quiroz, JA, Singh J, Gould TD, Denicoff KD, Zarate CA, Manji HK (2004) Emerging experimental treatments for bipolar disorder: clues from the molecular pathophysiology. Molecular Psychiatry. 8, 756-776. 16) Gould TD, Quiroz, JA, Singh J, Zarate CA, Manji HK (2004) Emerging experimental treatments for bipolar disorder: insight from the molecular and cellular actions of current mood stabilizers*. Molecular Psychiatry. 8, 734-755. *cover photo from issue 17) Yuan P, Gould TD, Gray NA, Bachmann RF, Schloesser RJ, Lan M, Du J, Moore GJ, Manji HK (2004) Neurotrophic signaling cascades are major long-term targets for lithium: clinical implications. Clinical Neuroscience Research. 4, 137-153. 18) Hao YL, Creson T, Zhang L, Li PP, Du F, Yuan P, Gould TD, Manji HK, Chen G (2004) Mood-stabilizer valproate promotes ERK pathway dependent cortical neuronal growth and neurogenesis. The Journal of Neuroscience. 24, 6590-6599. 19) Gould TD and Manji HK (2004) The molecular medicine revolution in psychiatry: bridging
Page number 5
Curriculum Vitae, Todd D. Gould
the gap between basic neuroscience research and clinical psychiatry. Journal of Clinical Psychiatry. 65, 598-604. 20) Gould TD, Einat H, Bhat R, Manji HK (2004) AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test. International Journal of Neuropsychopharmacology. 7, 387-390. 21) Quiroz JA, Gould TD, Manji HK (2004) Molecular effects of lithium. Molecular Interventions. 4, 259-272. 22) Picchini AM, Manji HK, Gould TD (2004) GSK-3 and neurotrophic signaling: novel targets underlying the pathophysiology and treatment of mood disorders? Drug Discovery Today: Disease Mechanisms. 1, 419-428. 23) Bachmann RF, Schloesser RJ, Gould TD, Manji HK (2005) Mood stabilizers target cellular plasticity and resilience cascades: implications for the development of novel therapeutics. Molecular Neurobiology. 32, 173-202. 24) Gould TD and Manji HK (2005) Glycogen synthase kinase-3: a putative molecular target for lithium mimetic drugs. Neuropsychopharmacology. 30, 1223-1237. 25) Bachmann RF, Schloesser RJ, Gould TD, Manji HK (2005) Molecular and cellular neurobiological studies identify novel targets for the long-term actions of mood stabilizers. Clinical Approaches in Bipolar Disorders. 4, 46-55. 26) Gould TD and Gottesman II (2006) Psychiatric endophenotypes and the development of valid animal models. Genes, Brain, and Behavior. 5, 113-119. 27) Hasler G, Drevets WC, Gould TD, Gottesman II, Manji HK (2006) Toward constructing an endophenotype strategy for bipolar disorders. Biological Psychiatry. 60, 93-105. 28) Gould TD, Picchini AM, Einat H, Manji HK (2006) Targeting glycogen synthase kinase-3 in the CNS: implications for the development of new treatments for mood disorders. Current Drug Targets. 7, 1399-1410. 29) Gould TD (2006) Targeting glycogen synthase kinase-3 as an approach to develop novel mood stabilizing medications. Expert Opinion on Therapeutic Targets. 10, 377-392. 30) Gould TD, Einat H, O’Donnell KC, Picchini AM, Schloesser RS, Manji HK (in press) Betacatenin overexpression in the mouse brain phenocopies lithium-sensitive behaviors. Neuropsychopharmacology. 31) Gould TD, O’Donnell KC, Picchini AM, Manji HK (in press) Strain differences in lithium attenuation of d-amphetamine-induced hyperlocomotion: a mouse model for the genetics of clinical response to lithium. Neuropsychopharmacology. 32, 1321-1333.
Page number 6
Curriculum Vitae, Todd D. Gould
32) Gould NF, Holmes MK, Fantie BD, Luckenbaugh DA, Pine DS, Gould TD, Burgess N, Manji HK, Zarate CA (2007) Performance on a virtual reality spatial memory task in depressed patients. The American Journal of Psychiatry. 164, 516-519. 33) Gould TD, Dow ER, O’Donnell KC, Chen G, Manji HK (2007) Targeting signal transduction pathways in the treatment of mood disorders: recent insights into the relevance of the Wnt pathway. CNS & Neurological Disorders - Drug Targets. 6, 193-204. 34) Gould TD and Manji HK (2007) Targeting neurotrophic signal transduction pathways in the treatment of mood disorders. Current Signal Transduction Therapy. 2, 101-110. 35) O’Donnell KC and Gould TD (2007) The behavioral actions of lithium in rodent models: leads to develop novel therapeutics. Neuroscience and Biobehavioral Reviews 36) Gould TD, O’Donnell KC, Dow ER, Chen G, Manji HK (submitted) Involvement of AMPA receptors in the antidepressant-like effects of lithium in the mouse tail suspension test and forced swim test. 37) Gould TD, O’Donnell KC, Picchini AM, Dow ER, Chen G, Manji HK (submitted) Generation and behavioral characterization of beta-catenin forebrain-specific knockout mice. Book Chapters & Non Peer Reviewed Publications 1) Gould TD, Gray NA, Manji HK (2003) The cellular neurobiology of severe mood and anxiety disorders: implications for the development of novel therapeutics. In: Molecular Neurobiology for the Clinician; APA Review of Psychiatry Series, Charney DS editor, Oldham JM, Riba MB series editors, American Psychiatric Publishing, Inc., Washington, DC, pp 123-227. 2) Manji HK, Quiroz J, Gould TD (2003) Cellular resilience and neuroplasticity in mood disorders. Psychiatric Times. January, pp 55-59. 3) Szabo ST, Gould TD, Manji HK (2003) Introduction to neurotransmitters, receptors, signal transduction, and second messengers. In: The American Psychiatric Publishing Textbook of Psychopharmacology, 3rd edition, Schatzberg AF, Nemeroff CB editors, American Psychiatric Publishing, Washington, DC, pp 3-52. 4) Du J, Gould TD, Manji HK (2003) Neurotrophic signaling in mood disorders. In: Signal Transduction and Human Disease, Finkel T, Gutkind JS, Wiley-Interscience editors, Hoboken, New Jersey, pp 411-445. 5) Payne JL, Quiroz J, Gould TD, Zarate CA, Manji HK (2003) Neurobiology of bipolar disorder. In: Neurobiology of Mental Illness, 2nd edition, Charney DS, Nestler EJ editors, Oxford University Press, New York, NY, pp 397-420.
Page number 7
Curriculum Vitae, Todd D. Gould
6) Gottesman II, Gould TD (2004) The endophenotype concept in psychiatry: etymology and strategic intentions. In: Research Advances in Genetics and Genomics: Implications for Psychiatry. Andreasen NC editor, American Psychiatric Publishing, Inc., Arlington, VA, pp 63-84 [Reprint of # 7 above]. 7) Yuan P, Zhou R., Farzad N, Gould TD, Gray NA, Du J, Manji HK (2005) Enhancing resilience to stress: the role of signaling cascades. In: Handbook of Stress and the Brain: Part 1, The Neurobiology of Stress, Steckler T, Kalin N, Reul JMHM editors, Elsevier Science Publication Company, San Diego, CA, pp 751-771. 8) Singh J, Quiroz JA, Gould TD, Zarate CA, Manji HK (2006) The molecular and cellular neurobiology of severe mood disorders. In: The American Psychiatric Publishing Textbook of Mood Disorders, Stein DJ, Kupfer DJ, Schatzberg AF editors, American Psychiatric Publishing, Inc., Arlington, VA, pp 197-218. 9) Quiroz JA, Szabo ST, Gould TD, Zarate CA Jr, Manji HK (2006) The intracellular neurobiology as a future challenge for the psychopharmacology. In: History of Psychopharmacology, 2nd Edition, F. López-Muñoz, C. Alamo editors, Editorial Medica Panamericana, Madrid, Spain, pp 273-330. 10) Gould TD and Manji HK (2006) Glycogen synthase kinase-3: a target for novel mood disorder treatments. In: Glycogen Synthase Kinase-3 (GSK-3) and its Inhibitors: Drug Discovery and Development, Marinez A, Castro A, Medina M editors, John Wiley & Sons, Inc., Hoboken, NJ, pp 125-154. 11) Gould TD, O’Donnell KC, Manji HK (2006) Glycogen synthase kinase-3: a target for the development of novel treatments for mania. In: New Developments in Mania Research, Kotlar MB editor, Nova Science Publishers, Inc., Hauppauge, NY, pp 135-159. 12) Szabo ST, Gould TD, Manji HK (in press) Introduction to neurotransmitters, receptors, signal transduction, and second messengers. In: The American Psychiatric Publishing Textbook of Psychopharmacology, 4th edition, Schatzberg AF, Nemeroff CB editors, American Psychiatric Publishing, Washington, DC. Editorials and Commentaries 1) Gould TD and Manji HK (2005) DARPP-32: a molecular switch at the nexus of reward pathway plasticity. Proceedings of the National Academy of Sciences of the United States of America. 102, 253-254. 2) Gould TD and Einat H (in press) Animal models of bipolar disorder and mood stabilizer efficacy: a critical need for improvement. Neuroscience and Biobehavioral Reviews. Invited Presentations (selected) 2003 NIMH 7th Annual IRP Scientific Retreat, Gettysburg, PA
Page number 8
Curriculum Vitae, Todd D. Gould
2004 2005 2005 2006 2006 2006 2006 2006 2006 2006 2006 2006 2006 2006 2006 2006 2006
Winter Conference on Brain Research, Copper Mountain, CO Society of Biological Psychiatry meeting, Atlanta, GA American College of Neuropsychopharmacology (ACNP) meeting, Waikoloa Village, HI Lilly Research Laboratories, Indianapolis, IN Society of Biological Psychiatry meeting, Toronto, Canada International Behavioral Neuroscience Society meeting, Whistler, Canada Case Western Reserve University Department of Pharmacology Research Seminar, Cleveland, OH Uniformed Services University of the Health Sciences, Department of Psychiatry Research Seminar, Bethesda, MD Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences Research Seminar, Houston, TX John’s Hopkins University, Department of Psychiatry and Behavioral Sciences Research Seminar Series, Baltimore, MD University of Colorado Health Sciences Center, Department of Psychiatry Research Seminar, Denver, CO Duke University, Institute for Genome Sciences & Policy and Division of Neurology Research Seminar, Durham,, NC Case Western Reserve University, Department of Psychiatry Grand Rounds, Cleveland, OH Brecksville Veterans Administration Hospital, Department of Psychiatry Grand Rounds, Brecksville, OH West Virginia University, Department of Behavioral Medicine & Psychiatry Research Seminar, Morgantown, WV University of Maryland, Department of Psychiatry Grand Rounds University of Miami Miller School of Medicine, Department of Psychiatry & Behavioral Sciences Grand Rounds, Miami FL
Abbreviated Bio Dr. Todd D. Gould, MD (University of Virginia) is an Assistant Professor of Psychiatry, within the University of Maryland School of Medicine Mood and Anxiety Disorders Program. He completed fellowship training at the National Institute of Mental Health (NIMH) Laboratory of Molecular Pathophysiology and Experimental Therapeutics where he held positions as the NIMH Seymour S. Kety Memorial Research Fellow and Lilly/NIMH Neuroscience Research Fellow. His research uses molecular, cellular, and behavioral approaches to study the pharmacology of psychotropic medications and the underlying pathophysiology of psychiatric illness, with a particular focus on the study of novel antidepressants and mood stabilizers and the development of improved animal models in psychiatry as well the functional consequences of mood disorder susceptibility genes. Since completing medical training in 2001, he has authored over 40 journal and textbook articles. He is Co-founder and Co-director of the course, Neurobiology of Mental Illness, which is offered through the Foundation for the Advanced Education in the Sciences at the NIH. This is a three credit, one semester graduate level, course that introduces the biological basis of and emerging methodologies (both basic science and clinical) needed in the study of neuropsychiatric disorders. Dr. Gould has received numerous awards including a Young Investigator Award from the National Association for Research on
Page number 9
Curriculum Vitae, Todd D. Gould
Schizophrenia and Depression (NARSAD), a Collegium Internationale NeuroPsychopharmacologicum (CINP) Young Investigator Rafaelsen Scholar Award, a Lilly Fellowship Award from the Society of Biological Psychiatry, an American College of Neuropsychopharmacology (ACNP) Young Investigator Memorial Travel Award, an International Behavioral Neuroscience Society Travel Award, and was selected to attend the 2005 Pittsburgh/Stanford Career Development Institute in Psychiatry.
Page number 10