Navesh K. Sharma, DO, PhD
Curriculum Vitae
Navesh K. Sharma, DO, PhD Assistant Professor, Department of Radiation Oncology University of Maryland Medical Systems Contact Information Department of Radiation Oncology 22 S. Greene Street Baltimore, MD 21201 Tel:
(410)328-7617
Fax:
(410)328-5279
E-mail:
Navesh@gmail.com
Languages: Fluent in Hindi
Education 11/1995
Bachelor of Science in Biology (emphasis in genetics), Summa Cum Laude, St. Cloud State University, St. Cloud, MN
07/2000
Doctor of Philosophy Department of Anatomy and Cell Biology University of Iowa College of Medicine Thesis Title: Dynamic Remodeling of Prostatic Adenocarcinoma Microenvironment by Tumor Cells: A Mechanism for Survival and Dissemination? Thesis Advisor: Mary J.C. Hendrix, PhD
05/2005
Doctor of Osteopathic Medicine Kansas City University of Medicine and Biosciences- COM Kansas City, MO
Navesh K. Sharma, DO, PhD
Post Graduate Education and Training 07/2000 - 06/2001 H. B. Wallace Postdoctoral Fellowship Department of Anatomy and Cell Biology University of Iowa College of Medicine, Iowa City, IA
06/2005 - 06/2006 Transitional Year Residency Mercy Catholic Medical Center Darby, PA 19023
07/2006 – 06/2010 Residency in Radiation Oncology Fox Chase Cancer Center Philadelphia, PA
Certifications 06/2006
Diplomate- National Board of Osteopathic Medical Examiners
Medical Licensure 10/2006- Present
Unrestricted Medical Licensure- State of Pennsylvania (Active)
02/2007- Present
Drug Enforcement Administration- Unrestricted Licensure (Active)
Professional society Memberships 1996- Present
American Association for Cancer Research
2001- Present
American Osteopathic Association
2006- Present
American Society for Radiation Oncology
Navesh K. Sharma, DO, PhD
2006- Present
American Society for Clinical Oncology
2006- Present
American Radium Society
2006- Present
Radiological Society of North America
Honors and Awards 11/1995
Graduated Summa cum Laude, St. Cloud State University, St. Cloud, MN
08/1997
Inducted into Sigma Xi National Science Honor Society
12/1998
Young Investigator Research Award, American Association for Cancer Research, Palm Springs, CA
11/2000
Young Investigator Award, Society for Basic Urologic Research, Sanibel, FL
05/2002-03
Excellence in Biomedical Research Fellowship, Kansas City University of Medicine and Biosciences, Kansas City, MO
2002, 03, 04
Best Medical Student Research Award, Kansas City University of Medicine and Biosciences, Kansas City, MO
05/2005
Basic Science Research Award, Kansas City University of Medicine and Biosciences, Kansas City, MO
08/2008
Selected for ASCO/AACR Methods in Clinical Cancer Research Workshop, Vail, CO
07/2008-06/09
Chief Resident, Fox Chase Cancer Center, Philadelphia, PA
09/2008
Radiation Therapy Oncology Group Fellowship, Philadelphia, PA
04/2009
Young Oncologist Essay Award, American radium Society, Vancouver, BC
07/2009
RSNA Roentgen Resident/Fellow Research Award
02/2010
ASTRO Abstract Award- Multidisciplinary Head and Neck Cancer Meeting, Chandler, AZ
Navesh K. Sharma, DO, PhD
Clinical Activities 07/2006- Present
Proficient in Stereotactic Radiosurgery (SRS), Stereotactic Body Radiotherapy (SBRT), Intensity Modulated Radiation Therapy (IMRT) and 3-Dimensional conformal (3DCRT) external beam radiation therapy techniques. Proficient in low dose rate and high dose rate brachytherapy techniques.
Administrative Service 09/2009- Present
Member, ASTRO Radiation and Cancer Biology Committee
09/2009- Present
Member, ASTRO Emerging Technologies Committee
01/2009- Present
Ad hoc Reviewer, Cancer
01/2009- Present
Ad hoc Reviewer, American Journal of Clinical Oncology
Teaching Service 1996
Graduate Teaching Assistant, Dental Histology, University of Iowa, Iowa City, IA
1997
Graduate Teaching Assistant, Dental Gross Anatomy, University of Iowa, Iowa City, IA
1997
Graduate Teaching Assistant, Medical Neuroscience, University of Iowa, Iowa City, IA
2000- 01
Graduate Instructor, University of Iowa Student Athlete Tutoring Program, Iowa City, IA
2002- 05
Peer Tutor, Medical Pharmacology, Kansas City University of Medicine and Biosciences, Kansas City, MO
Navesh K. Sharma, DO, PhD
Publications Peer-reviewed journal artiles
1. Luo J, Sharma NK, Seftor EA, DeLarco JE, Heidger PM, Hendrix MJC, Lubaroff DM. (1997) Heterogeneous Expression of Invasive and Metastatic Properties in a Prostate Tumor Model. Pathol. Oncol Res., 3: 264-271. 2. Sharma NK, Luo J, Kirschmann DA, O’Malley Y, Robbins ME, Akporiaye ET, Lubaroff DM, Heidger PM, Hendrix MJC. (1999) A Novel Immunological Model for the Study of Prostate Cancer. Cancer Res., 59: 2271-276. 3. Sharma NK, Seftor RE, Seftor EA, Gruman LM, Heidger PM, Cohen MB, Lubaroff DM, Hendrix MJC. (2002) Prostatic Tumor Cell Plasticity Involves Cooperative Interactions of Distinct Phenotypic Subpopulations: Role in Vasculogenic Mimicry. Prostate, 50(3): 189-201. 4. Sharma NK, Sorosky JI, Bender D, Fletcher MS, Sood AK. (2005) Malignant Mixed Mullerian Tumor (MMMT) of the Cervix. Gynecol. Oncol., 97(2): 442-5.
5. Anderson P, Freedman GM, Sharma NK, Nicolaou N, Topham N, Morrow M. (2009) Post-mastectomy Chest Wall Radiation to a Temporary Tissue Expander or Permanent Breast Implant- Is There a Difference in Complication Rates? Int. J. Rad. Oncol. Biol. Phys., 74(1):81-5. 6. Sharma NK, Cohen RJ, Eade TN, Buyyounouski MK, Li J, McNeeley S, Crawford K, Chen YT, Uzzo RG, Horwitz, EM. (2009) An Intra-operative Realtime Sleeved Seed Technique for Permanent Prostate Brachytherapy. Brachytherapy. In press/electronic publication available 7. Turaka A, Li T, Sharma, NK, Li L, Nicolaou N, Mehra R, Burtness B, Cohen RB, Lango MN, Horwitz EM, Ridge JA, Feigenberg SJ. (2009) Increased Recurrences Using Intensity Modulated Radiation Therapy in the Postoperative Setting. Am. J. Clin. Oncol. In press/electronic publication available 8. Sharma NK, Li TL, Pollack A, Chen YT, Horwitz EM, Buyyounouski MK. (2010) Intensity Modulated Radiation Therapy Reduces Gastrointestinal Morbidity in Patients Treated with Androgen Deprivation Therapy for Prostate Cancer. Int. J. Rad. Oncol. Biol. Phys. Accepted 9. Sharma NK, Silverman JS, Li TL, Cheng J, Yu JQ, Haluszka O, Scott W, Meropol NJ, Cohen SJ, Freedman GM, and Konski AA. (2010) Decreased Posttreatment SUV on PET Scan is Associated With Improved Local Control in Medically Inoperable Esophageal Cancer: The Fox Chase Cancer Center Experience. Gastrointest. Cancer Res. Accepted
Navesh K. Sharma, DO, PhD
Book Chapters 1. Hendrix MJC, Luo J, Seftor EA, Sharma NK, Heidger PM, Cohen MB, Bhatty R, Chunthapong J, Seftor REB, Lubaroff DM. (2007) Epithelial-mesenchymal Molecular Interactions in Prostatic Tumor Cell Plasticity. In Metastasis of Prostate Cancer Ablin. R.J., and Mason, M.D., Eds.; Springer: Amsterdam, Vol. 10, pp 127-141.
Proferred Communications 1. Sharma N, Luo J. Seftor EA, DeLarco JE, Heidger PM, Hendrix MJC and Lubaroff DM. Phenotypic Correlates of Invasion in Prostatic Cancer Cells. Poster presentation at the AACR annual meeting, April 1997. Proc. Amer. Assoc. Cancer Res.38: 547, 1997. 2. Luo J, Sharma N, Seftor EA, Heidger PM, Lubaroff DM, and Hendrix MJC. Heterogeneous Expression of E-cadherin/catenin Complex and its Modulation by E-cadherin Transfection in Prostate Cancer Cells. Poster presentation at the AACR annual meeting, April 1998. Proc. Amer. Assoc. Cancer. Res. 39: 500, 1998. 3. Sharma N, Luo J, Lubaroff DM, Heidger PM, and Hendrix MJC. A Novel TumorImmunological Model for the Study of Prostate Cancer. Poster presentation at the AACR annual meeting, April 1998. Proc. Amer. Assoc. Cancer. Res. 39: 614, 1998. 4. Maniotis AJ, Hess AR, Seftor REB, Seftor EA, Sharma N, Gruman-Gardner LM, Folberg R, and Hendrix MJC. Vascular Channel Formation by Human Melanoma Cells In Vitro and In Vivo: Vasculogenic Mimicry. Oral presentation at the ARVO annual meeting, April 1998. 5. Sharma N, Luo J, Maniotis AJ, Kirschmann DA, Heidger PM, Lubaroff DM, and Hendrix MJC. Tumor Cell Mediated Immunosuppression and Angiogenesis in the Dunning Gelatin-Sponge Retrieval System. Poster presentation at the AACR special meeting “New Research Approaches in the Prevention and Cure of Prostate Cancer,� December 1998. 6. Sharma N, Seftor REB, Seftor EA, Heidger PM, Cohen MB, Folberg R, Miller, GJ, Lubaroff DM, and Hendrix MJC. Vasculogenic Mimicry by Aggressive Prostate Cancer: Molecular Mechanisms Contributing to Invasive Behavior. Oral presentation at the FASEB Annual Meeting, April 2000. FASEB J. 14: A272, 2000. 7. Sharma NK, Seftor REB, Seftor EA, Lubaroff DM, Heidger PM and Hendrix MJC. Dynamic Remodeling of Prostate Adenocarcinoma Microenvironment: Role of Individual Tumor Cell Populations in Development of Patterned Tubular
Navesh K. Sharma, DO, PhD
Intratumoral Networks. Oral presentation at the Society for Basic Urologic Research Fall Symposium, November, 2000. 8. Sharma NK, Seftor REB, Seftor EA, Lubaroff DM, Heidger PM and Hendrix MJC. Formation of Patterned Intratumoral Networks in Aggressive Heterogeneous Prostate Cancer: Molecular Determinants and Role of Individual Populations. Poster presentation at the AACR annual meeting, April 2001. Proc. Amer. Cancer. Res. 42: 110, 2001. 9. Sharma NK. Dynamic Remodeling of Prostatic Adenocarcinoma Microenvironment by Tumor Cells: A Mechanism for Tumor Survival and Dissemination? Oral presentation at the 10th Annual UHS Research Symposium, January 2002. 10. Sharma NK, Sharma CG, and Peffley DM. Genistein, Perillyl Alcohol and ÎłTocotrienol Differentially Influence PC3 and DU145 Prostate Cancer Cells In Vitro. Oral presentation at the 11th Annual UHS Research Symposium, January 2003.
11. Sharma NK, Hentosh P, and Peffley DM. Differential Inhibition of Invasive Properties in PC3 and DU145 Prostate Cancer Cells by Genistein, Perillyl Alcohol and Îł-Tocotrienol. Poster presentation at the AACR annual meeting, July 2003. Proc. Amer. Assoc. Cancer Res.44: 611, 2003. 12. Sharma NK, Sharma CG, and Peffley DM. Inhibition of Molecular Pathways Involved in Prostatic Adenocarcinoma Invasion and Metastasis by Genistein and Perillyl Alcohol: A Potential Therapeutic Intervention Strategy? Poster presentation at the 12th Annual UHS Research Symposium, January 2004. 13. Sharma NK, Ruth K, Horwitz E, Buyyounouski M, and Pollack A. Statin use During Radiation Therapy Does not Improve Outcome: The Fox-Chase Experience. Poster presentation at the 48th ASTRO annual meeting, November 2006. Int. J. Rad. Oncol. Biol. Phys. 66(3): S366, 2006. 14. Sharma NK, Pollack A, Horwitz EM, Li T, and Buyyounouski MK. Intensity Modulated Radiation Therapy Reduces Gastrointestinal Morbidity in Patients Treated with Androgen Deprivation Therapy for Prostate Cancer. Oral Presentation at the 49th ASTRO annual meeting, October, 2007. Int. J. Rad. Oncol. Biol. Phys. 69 (3): S10, 2007. 15. Sharma NK, Silverman JS, Li T, Cheng J, Yu JQ, Haluszka O, Scott W, Meropol N, Cohen SJ, Freedman GM, and Konski AA. Decreased Post-Treatment SUV on PET Scan is Associated With Improved Local Control in Medically Inoperable Esophageal Cancer: The Fox Chase Cancer Center Experience. Oral
Navesh K. Sharma, DO, PhD
presentation at the 90th ARS annual meeting, May, 2008. Oncology 22(4): 7, 2008. 16. Feigenberg SJ, Sharma NK, Wang L, Cohen R, Buyyounouski MK, Lally BE, and Movsas B. Phase I Dose Escalation Trial of Image Guided Stereotactic Body Radiotherapy for Lung Tumors. Poster discussion at the 50th annual ASTRO meeting, September, 2008. Int. J. Rad. Oncol. Biol. Phys. 72(1): S114, 2008. 17. Sharma NK, Ruth K, Konski AA, Buyyounouski MK, Nicolaou N, Lally BE, Yu JQ, Langer CJ, Movsas B, and Feigenberg SJ. Low Morbidity and Excellent Local Control Using Image Guided Stereotactic Body Radiotherapy (IGSBRT) for Lung Tumors. Poster Presentation at the 50th annual ASTRO meeting, September, 2008. Int. J. Rad. Oncol. Biol. Phys. 72(1): S454, 2008. 18. Sharma NK, Ruth K, Yu JQ, Nicolaou N, Buyyounouski MK, Konski AA Movsas B, and Feigenberg SJ. A 55% Decrease in Maximal 18- Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) Standardized Uptake Value (SUV) May Predict for Local Control Following Image Guided Stereotactic Body Radiotherapy (IGSBRT) for Lung Cancer. Oral presentation at the 4th International Conference on Translational Research, March, 2009. Radiother. Oncol. 90(3):S46, 2009. 19. Sharma NK, Ruth KJ, Movsas B, Yu JQ, Buyyounouski MK, Konski AA, Lally BE, and Feigenberg SJ. A Low Initial Standardized Uptake Value on FDG-PET Scan May Predict for Decreased Local Control in Patients Treated with Image Guided Stereotactic Body Radiotherapy (IGSBRT) for Lung Cancer. Oral presentation the 91st ARS annual meeting, April, 2009. 20. Cohen RJ, Sharma NK, Li J, Ruth KJ, Buyyounouski MK, Crawford K, Uzzo RG, Horwitz EM. Sleeved Seeds Decrease Post-implant Hotspots in Real-time Intraoperatively Planned Permanent I-125 Prostate Implants. Poster presentation at The 2009 Annual ABS meeting, May, 2009. Brachytherapy, 8(2): 179. 21. Sharma NK, Cohen RJ, Ruth KJ, Crawford K, Li J, Buyyounouski MK, Feigenberg SJ, Uzzo RG, Horwitz EM. Sleeved Seeds Decrease Gastrointestinal and Genitourinary Toxicity Profiles in Real-time Intra-operatively Planned Permanent I-125 implants. Poster presentation at the 2009 Annual ABS meeting, May, 2009. Brachytherapy, 8(2): 179. 22. Cohen RJ, Sharma NK, Ruth KJ, Buyyounouski MK, Li J, Crawfor K, Feigenberg SJ, Chen DYT, Uzzo RG, Horwitz EM. Is MRI-based Week Three Post-implant Dosimetry Necessary following LDR Prostate Brachytherapy? Poster presentation at the 51st annual ASTRO meeting, November 2009. Int. J. Rad. Oncol. Biol. Phys. 75(3): S298, 2009.
Navesh K. Sharma, DO, PhD
23. Horwitz EM, Ruth KJ, Sharma NK, Chen DYT, Buyyounouski MK, Uzzo RG. Undetectable Post-treatment PSA Following 3DCRT or IMRT Alone for Patients with Low or Intermediate Risk Prostate Cancer is an Independent Predictor of Biochemical and Clinical Outcome. Poster presentation at the 51st annual ASTRO meeting, November 2009. Int. J. Rad. Oncol. Biol. Phys. 75(3): S301, 2009. 24. Sharma NK, Ruth KJ, Boorjian SA, Uzzo RG, Buyyounouski MK, Horwitz EM. Initial PSA (iPSA) and Radiation Dose Predict for an Undetectable PSA Following 3DCRT or IMRT for Low-intermediate Risk Prostate Cancer. Poster presentation at the 51st annual ASTRO meeting, November 2009. Int. J. Rad. Oncol. Biol. Phys. 75(3): S313, 2009. 25. Sharma NK, Harris, J, Horwitz EM, Langer CJ, Nicolaou N, Kies M, Curran WJ, Wong S, Ang KK. Age, Performance Status and Interval From Prior Radiation Therapy to Recurrence Predict for Overall Survival (OS) in Re-irradiated Head and Neck Cancer Patients Treated on RTOG 9911: Results of a Recursive Partitioning Analysis. Plenary presentation at the ATSRO/ASCO/AHNS multidisciplinary head and neck cancer meeting, February 2010.
Authored Abstracts 1. Sharma NK, Mehra R, Feigenberg SJ (co-principal investigators). (accrual to begin in Spring, 2010) A Phase I Study to Determine the Maximum Tolerable Dose (MTD) and Safety of the Mammalian Target of Rapamycin (mTOR) Inhibitor, RAD001, With Erlotinib™ and Concurrent External Beam Radiotherapy in the Re-irradiation Setting for Squamous Cell Carcinoma of the Head and Neck.
Navesh K. Sharma, DO, PhD