CURRICULUM VITAE Name:
Terez Shea-Donohue, Ph.D. Professor of Radiation Oncology, Medicine, and Physiology University of Maryland School of Medicine Baltimore, MD 21201
Business Address:
Division of Translational Radiation Science University of Maryland School of Medicine 10 Pine Street, MSTF Rm 700 C Baltimore, MD 21201 TEL (410) 706-5503 tdonohue@som.umaryland.edu Proficient in French
Education:
1976 B.A. Biology, Wheaton College, Norton, MA. 1980 Ph.D. Physiology and Biophysics, Georgetown University, Washington, DC
Post Graduate Training:
1980-1983 Postdoctoral Fellow, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD
Employment History: 1983-1992 Research Assistant Professor, Department of Medicine; Assistant Professor, Department of Physiology, Uniformed Services University of the Health Sciences, Bethesda, MD 1992-1999 Research Associate Professor, Department of Medicine; Associate Professor of Physiology, Department of Physiology, Uniformed Services University of the Health Sciences, Bethesda, MD 1992-2000 Associate Professor, Neuroscience Program, Uniformed Services University of the Health Sciences, Bethesda, MD (Secondary appointment) 2000-present Research Professor, Department of Medicine; Professor, Department of Anatomy, Physiology, and Genetics; Professor, Neuroscience Program 2001-2004 Research Physiologist, USDA-ARS, BHNRC, NFRL, Beltsville, MD 20705 2004-2013 Professor of Medicine (tenured), University of Maryland School of Medicine, Baltimore, MD 21201 2005-Present Professor of Physiology (secondary), University of Maryland School of Medicine, Baltimore, MD 21201 2013-Present Professor of Medicine (secondary), University of Maryland School of Medicine, Baltimore, MD 21201 2013-Present Professor of Radiation Oncology (tenured), University of Maryland School of Medicine, Baltimore, MD 21201 Professional Memberships: 1980-present American Gastroenterological Society 1990-present American Motility Society 2005-present American Association of Microbiologists
Terez Shea-Donohue, PhD., Page 2 of 19 . Honors and Awards: 1977-1980, NIH pre-doctoral fellowship 1997, Invitational Travel Award, International Motility Society, Lorne, Australia 1997, Janssen Award for Basic Research in Gastrointestinal Motility 1998 Member of the Advisory Board for the Janssen Award, 2000, Certificate of Appreciation, Department of Veterans Affairs, for meritorious service within the VA program review division of the Medical Research Service 2001, Meritorious Service Award, USUHS, 1979 - 2003; Outstanding Performance Rating, USUHS 2002, Certificate of Appreciation for Teaching, Department of Anatomy, Physiology, and Genetics, USUHS 2002, 2003; Merit Award, USDA 2003, Invitational Travel Award, International Motility Society, Barcelona, Spain 2005, Invitational Travel Award, International Motility Society, Toulouse, France 2007, Invitational Travel Award, International Neurogastroenterology and Motility Society, Jeju Island, Korea. 2007-2012, Teaching certificate for top 25% of teachers based on student evaluations in Structure Function of Organs Systems Course September, 2012- 2016 Rome IV Chapter Committee- This committee will work over the next 3 years leading to the publication of the Rome IV book in early 2016.
Institutional Service (USUHS 1990-2001; USDA 2001-2004) 1990-1991, Faculty Senate, Secretary 1989-1992, Biohazard and Safety Committee 1991-1994, Faculty Senator 1991-1994, Chair, Faculty Senate Comparability Committee 1994-1997, Merit Review Committee for Internal Grants 1992-1995, Graduate Education Committee 1992-1995, Chair, IACUC 1998, 1999, Co-chair Research Day 1997-1999, Graduate Education Committee 1997, Chair, USUHS Curriculum Review Committee: Gastrointestinal Section 1998-2001, Faculty Advisor to AOA program for MSI and MSII research 1999, LCME Self Study, Graduate Education Committee 1999-2001, Medical Student Awards Committee 2002-2004, Member, IACUC Institutional Service (University of Maryland) 2004-present, Appointments, Promotions, and Tenure Committee –Department of Physiology 2004-present, MD/Ph.D. Committee 2004-present, Mucosal Biology Research Center Steering committee 2005, 2007, Co-chair of Annual Mucosal Biology Research Center Symposium 2008-present, Appointments, Promotions, and Tenure Committee –Department of Medicine
Terez Shea-Donohue, PhD., Page 3 of 19 . July 2008- present, Track Leader for Cell and Molecular Physiology in the GPILS Molecular Medicine Program 2005-present Executive Committee, T32 Research Training in Gastroenterology. 2010 – present, Executive Committee, T32 Training Program in Integrative Membrane Biology National Service 2006-2008, American Gastroenterology Association, elected councilor for Section on Neurogastroenterology and Motility. Grant review 1996-1999, Veterans Administration Merit Review Subcommittee for Gastroenterology (full member, 3.5 years), 1999-present, Ad Hoc reviewer for NSF, Crohn’s and Colitis Foundation of America. 2001, American Motility Society Research Grant Awards Committee March, 2001; March, 2002; June, 2002; Temporary Member of NIH/NIDDK GMA2 2005, Ad hoc reviewer for Edyth Broad Foundation July 2002-July 2007; Member of NIH/NIDDK CIGP Study Section (term extended 1 year) June, 2005; member of the NIDDK ZDK1 GRB-2, PO1 application, Special Emphasis Panel/Project Program Grants July, 2003; March, June, October, 2004; March, 2005, March, 2007; reviewer NIDDK ZRG-1 Special Emphasis Panel, CIGP and GCMB study section June, 2006; March, 2007; Ad hoc member of the NIAID PTHE Special Emphasis Panel September, 2007; Ad Hoc reviewer for Welcome Trust, October 2007; Temporary member NIH/NIDDK CIGP Study Section December, 2007, Member of NIH/NIAID, PO1 application, Special Emphasis Panel/Project Program Grants. February, 2008; Temporary member NIH/NIDDK CIGP Study Section May, 2008; Member ZAI1-TP-M1 Review committee, NIAID June, 2008; Temporary member NIH/NIDDK CIGP Study Section March, 2009; Temporary member of ZAT1SM13 NIH/NCCAM. June, 2009; DKUS F96 SEP Review Panel NIIH/NCCAM November, 2009; Temporary member NIH/NIDDK CIMG Study Section March, 2010; NIAID Centers for Medical Countermeasures May, 2010; NIH/NIDDK ZRG-1 DKUS study section October 2010; NIH/NIDDK ZRG-1 DKUS study section (Chair) March 2011, NIAID Immune Defense Mechanisms at the Mucosa Cooperative Study Group April, 2011, NIH/NIDDK ZRG-1 DKUS study section (Chair) January, 2012; NIH/NIDDK ZRG-1 DKUS study section March, 2012;NIH/NIDDK ZDK1 GRB-8 (Chair) Ancillary Studies for the Intestinal Stem Cell Consortium June, 2012; NIH/NIDDK ZRG-1 DKUS study section October, 2012; NIH/NIDDK ZRG-1 DKUS study section January, 2013; NIH/NIDDK ZRG-1 DKUS study section March 2013; NIH/NIDDK ZRG-1 DKUS study section March, 2013: NIH/NIDDK ZRG1 DKUS-N (10) B Small Business Digestive Diseases April, 2013; NIH/NIDDK ZDK1 GRB-8 (M5) Ancillary Studies for the Intestinal Stem Cell Consortium July, 2013: NIH/NIDDK ZRG1 DKUS-N (10) B Small Business Digestive Diseases October, 2013 NIDDK ZDK1 GRB-2, PO1 application.
Terez Shea-Donohue, PhD., Page 4 of 19 . February, 2014; Temporary member NIH/NIDDK CIGP Study Section. Editorial Associate Editor, Gut Microbes Editorial Board, Neurogastroenterology and Motility, American Journal of Physiology, Infection and Immunity, Frontiers in Physiology Regular reviewer for Gastroenterology; Journal of Immunology Education 2005-2009; Working Team on Gastrointestinal Motility and its Control in Health and Disease. This is a collaborative effort between the World Congress of Gastroenterology (Montreal 2005) and AstraZeneca (educational grant) to create a new set of teaching/research materials in this field Organizing committees for National/International Meetings 2003, International Steering Committee for Banff Enteric Nervous System Conference, Calgary, Canada 2006, Organizing committee for Joint International Neurogastroenterology and Motility, Boston MA 2001-2007, 2012 Steering Committee for International Symposium on Neurogastroenterology and Motility Abstract Selection Committees for National/International Meetings 1993-1996, Abstract selection committee, Esophagus, Gastric and Duodenal Disorders, American Gastroenterological Association 1998, Abstract selection committee, Nerve Gut Motility, American Gastroenterological Association 2003, Abstract selection committees, American Gastroenterological Association, Free Radical Biology, Splanchnic Circulation, and Neuroimmune Regulation of Motility 2003, Abstract selection committee, Enteric Nervous System Symposium, Banff, Canada 2003, Abstract selection committee, 19th International Motility Symposium, Barcelona, Spain 2001, 2004, 2005; Abstract selection committees, American Gastroenterological Association, Free Radical Biology, Splanchnic Circulation, and Chair, Neuroimmune Regulation of Motility 2006-2009, Abstract Selection Committee, American Gastroenterological Association, Hormones, transmitters, growth factors and their receptors 2007, Abstract Selection Committee, 20th International Symposium on Neurogastroenterology and Motility 2010, Abstract Selection Committee, American Gastroenterological Association, Neuroimmune interactions 2011, Chair, Abstract Selection Committee, American Gastroenterological Association, Neuroimmune Modulation of Gut Function, Including Inflammation, Infection and the Microbiome. 2011, Chair, Abstract Selection Committee, American Gastroenterological Association, Neuroimmune Modulation of Gut Function, Including Inflammation, Infection and the Microbiome. 2012, Abstract Selection Committee, American Neurogastroenterology and Motility Society, Neuroimmune Modulation of Gut Function. 2013, Chair, Abstract Selection Committee, American Gastroenterological Association, Sensory Neurobiology Including Visceral Nociception/Pain & Neuroimmunology (Neurogenic Inflammation & Interactions with the Microbiome)
Terez Shea-Donohue, PhD., Page 5 of 19 . 2014, Abstract Selection Committee, American Gastroenterological Association, Sensory Neurobiology Including Visceral Nociception/Pain & Neuroimmunology (Neurogenic Inflammation & Interactions with the Microbiome) Teaching Uniformed Services University of the Health Sciences 1984-2004, Department of Physiology, (alternate years). I taught a graduate level course in Gastrointestinal Physiology (2-3 credits). 1991-2004, Section Leader, Gastrointestinal Physiology. This entailed developing and modifying course content, as well as preparation of handouts for the section on gastrointestinal physiology (15-18 hours of lecture) for first year students. I also worked with student academic representatives to schedule review sessions as well as coordinate changes in the schedule 1992-1997, Summer Medical Student Prematriculation Program. This was a pilot program to test the effectiveness of early intervention on academic success in the first year for students with disadvantaged backgrounds, non-science majors, or students who had been out from the academic setting for a period of years. I gave 3 hours of lecture/discussion as well hand out materials on selected topics in gastrointestinal physiology. 1998 – 2004, Section leader, Gastrointestinal Physiology, Graduate School of Nursing. This entailed developing and modifying course content, as well as preparation of handouts for the section on gastrointestinal physiology (5-7 hours of lecture) for students in the programs in Nurse Anesthesiology, Family Practice, and Clinical Nursing Specialists, as well as for graduate students in Medical Psychology. 1998 – 1999, Course Director, Medical Physiology. I was responsible for the overall coordination of the Medical Physiology course (9 credits) for first year students. 1999-2001, Course Director, Structure and Function of Organs Systems (SFOS). This is an integrated course with more than 130 faculty from both clinical and basic sciences. 2001-2006, Lecturer in Introduction to Neuroscience, Neuroscience Program, USUHS (). I gave 2 hours of lecture on the autonomic and enteric nervous systems. George Washington University School of Medicine 1993- present, Section leader, Gastrointestinal Physiology, Medical Physiology, George Washington School of Medicine, Washington, DC. University of Maryland 2007-2008, Assistant Director GPILS 645, Physiological Basis of Molecular Medicine 2008-2009, Director GPILS 645, Physiological Basis of Molecular Medicine 2004-present, Graduate Program, 3 classes (6 hours) in Cell and Systems Physiology (GPLS 645), 1 class (3 hours) in Basic Immunology (GPLS. 702), 1 class in Advanced Immunology (GPLS 719). 2004-present, Lecturer, Gastrointestinal Physiology, Functional Systems, University of Maryland School of Medicine Lecturer in Medical Physiology. I have 6 hours of lecture contact time with the first year medical students. 2004-present, Instructor in the Fellows Core Curriculum Course sponsored by the Division of Gastroenterology, Department of Medicine. I give approximately 2-4 hours of lecture/year on basic science topics in Gastroenterology. 2011-2013, Course Director, Topics In Molecular Medicine 2009-present, Track leader, Molecular Physiology and Pharmacology in the Molecular Medicine Program of GPLS.
Terez Shea-Donohue, PhD., Page 6 of 19 .
2013 - present, Section leader, Gastrointestinal Physiology, Functional Systems, University of Maryland School of Medicine Lecturer in Medical Physiology. I have 10 hours of lecture contact time with the first year medical students.
Training Graduate Students (USUHS) P. Lynn Touzeau, Department of Physiology, Major advisor, graduated May, 1989. Elizabeth Montcalm, Department of Physiology, Major advisor, graduated May, 1991 Jeannette Hosseini, Department of Physiology, Major advisor, graduated May, 1996 Carol Bossone, Department of Physiology, Major advisor, graduated May, 1998 Mark Crago, Department of Physiology, Research thesis committee, graduated May, 1999 George A. Steer, Department of Anatomy , Physiology and Genetics, Research thesis committee, graduated May, 2001 COL Cheryl DiCarlo, Department of Anatomy , Physiology and Genetics, Research thesis committee, graduated May, 2002 Other Gerardo Hernandez, Department of Physiology, Ponce School of Medicine, Ponce, PR, graduated May, 2004. Eric Yu, Department of Physiology and Biophysics, University of Calgary, Calgary, Canada, graduated June, 2009 Graduate Students (University of Maryland) Thesis committee member (meet at least twice yearly) Kelly Baker, Microbiology and Immunology , thesis committee member, 2004-2009 Maura Staunton, Microbiology and Immunology , thesis committee member, 2004-2008 Preeta Dasgupta, Microbiology and Immunology , thesis committee member, 2004-present Kristina Harris, Molecular Medicine, thesis committee member, 2006-2009 Julie Craig, Molecular Medicine, thesis committee member, 2009-present Tiha Long, Microbiology and Immunology Program, thesis committee member, 2011- present Sarah Morgan (nee Horvat), Molecular Medicine, thesis committee member, 2011- present Craig Sturgeon, Molecular Medicine, thesis committee member, 2011- present Shannadora Hollis, Molecular Medicine, thesis committee member, 2011- present Nate Archer, Molecular Medicine, thesis committee member, 2011- present Drew Roberts Molecular Medicine, thesis committee member 2012-present Gloria Sernea, Molecular Medicine, thesis committee member 2012-present Mentor Jennifer Bohl (nee Stiltz), Molecular Medicine, Research Mentor, 2008-June, 2013 Rex Sun, Molecular Medicine, Research Mentor, 2009-present Leon McLean, M.D., Molecular Medicine, Research Mentor, 2010-present Postdoctoral Fellows 1991-1994, Dr. Jon Goldhill,
Terez Shea-Donohue, PhD., Page 7 of 19 .
1999-2002, Dr. Sherry Fleming, co-supervised with Dr. George Tsokos 1999-2004, Dr. Aiping Zhao 2003- 2005, Dr. Motoko Morimoto 2008-2012, Dr. Luigi Notari
Gastroenterology Fellow Research Advisor ( Walter Reed Army Medical Center) 1987-1988, Dr. Tina Sodhi 1989-1990, Dr. Carl Stamm 1990-1991, Dr. William Pearce 1991-1992, Dr. Tom Pellar Pediatric Gastrointestinal Fellow Research Advisor (Walter Reed Army Medical Center) 1993-1995, Dr. Carolyn Sullivan 2000-2002, Dr. Karla Au Yeung 2003-2005, Dr. Blaine Huft 2004-2006, Dr. Thomas Sutton 2006-2008, Dr. Diana Riera 2008-2010, Dr. Justin Devito 2011-present Dr. Kevin O’Meara Medicine Residents (University of Maryland) 2006 – 2007, Dr. Leon McLean Surgical Resident Research Advisor (beginning with their research year) 1994-1995, Dr. Alexander Stojadinovic 1995-1996, Dr. Benjamin Starnes 1996-1997, Drs. Thomas Miner and Houman Tavaf-Motamen 1997-1998, Drs. Christopher Gallagher and William C. Conner 1998-1999, Drs. Steven Lawson and David Ward 1999-2000, Dr. Ray Petrofsky (Urology) 1999-2000, Dr. Scott Rehrig 2000-2001, Dr. Jimie Anderson 2001-2002, Dr. Christopher Swiecki 2002-2003, Dr. Sunny Kim 2003 to 2004, Dr. Bradford Scanlan High School and College Students (1995-2004) Thomas Catherwood Julie Nealon (3 years) Ambrose Dieringer (2 years) Gary White Brian Chap (4 years) Courtney Byrd Daniel Mulloy (2 years) Daniel Leibowitz
Terez Shea-Donohue, PhD., Page 8 of 19 . Tramell Tillman (1 year intern from Roosevelt High School, Beltsville, MD) Students, clinical and postdoctoral fellows have received numerous awards including the Bailey Kay-Ashford Award for basic science research (1998, 2000, 2001, 2006 (finalist)); The Hufnagel Award for Outstanding Research in Surgery (1996; 1999; 2001; second place 2003); Surgical Trauma Award (1996, 1998, 1999, 2000, 2001, 2002); American Motility Society outstanding student/trainee abstract (1994, 1996); International Motility Society outstanding student/trainee abstract (1995, 1997); Ogden Bruton Research Award, Uniformed Services Pediatric Seminar (first place 1995, 1997, second place 2003, third place 2006, first place 2010); American Motility Society Young Scientist Award (2000, 2002); American Gastroenterology Association student/trainee abstract research award (1989, 1990, 1991, 1995,1998, 2001); International Motility Society Outstanding Young Investigator Award (2001); Winner Roosevelt High School Science Fair (Medical section) 2002. Grant Support Current support NIH/NIDDK “Novel Cytokine Regulation of Gut Inflammation and Function” Principal Investigator: Aiping Zhao, M.D., University of Maryland Baltimore Role on project: CoInvestigator (5% effort). NIH/NIDDK T32 DK067872-01 "Research Training in Gastroenterology” Principal Investigator, Jean-Pierre Raufman, July 2005-June 2010, role on project, coordinator of Adult GI Research (no effort). NIH/NIAID-DAIT-05-37 “Medical Countermeasures Against Radiological Threats: Product Development Support Services”, Principal Investigator, Tom MacVittie, Role on Project: Coinvestigator (50% effort). Completed Support (since at University of Maryland) NIH/NIAID RO1 AIDK49316, "GI Nematodes and Functional Responses to Inflammation,” December 1, 2007 – November 30, 2014 (NCE). Role on project: Principal Investigator (20% effort), direct costs $250,000/year. NIH/NIAID-DAIT-05-37 “Medical Countermeasures Against Radiological Threats: Product Development Support Services”, Principal Investigator, Tom MacVittie, Role on Project: Consultant (10% effort). NIH/NIAID RC1AI78520-01 “Nonhuman Primate Model of Post-Irradiation Insult to Gut Mucosa: Pathophysiological and Therapeutic Aspects”, September 1, 2007 – February 28, 2010 (NCE February 28, 2011), Role on project: Principal Investigator (20% effort), direct costs $505,050 (ARRA supplement , August, 2010, $300,000). NIH/NIAID U19AI082655 Mucosal Immunity, Vaccines and Microbiota Interplay in Humans and Animals Principal Investigator ,Marcelo Sztein, April 1, 2009-March 31, 2014. Role on Project CoInvestigator Project 4 (5% effort) NIH/NIAID U19AI090873 Enteric Research Investigational Network Cooperative Research Centers, Principal Investigator , James Kaper, July 20, 2010 – June 30, 2015. Role on Project CoInvestigator, Project 2 (5% effort) Patents: Publication number US 2012-0107329. EGFR and PAR2 regulation of Intestinal Permeability Pending
Terez Shea-Donohue, PhD., Page 9 of 19 .
Aiping Zhao, Terez Shea-Donohue. “Use of IL-25 as a therapeutic agent against obesity and the associated metabolic diseases”, US Provisional Patent Application Number: 61/461,122, filed on 01/13/2011 Aiping Zhao, Terez Shea-Donohue. “Helminth-induced immunotherapy for obesity and associated metabolic diseases”, US Provisional Patent Application Number: 61/504,753, filed on 07/06/2011
Publications: Peer Reviewed Articles 1. Bolger PM, Eisner GM, Shea T, Ramwell PW, Slotkoff LM. Effect of PGD2 on canine renal function. Nature 1977; 267: 677. 2. Shea-Donohue T, Bolger PM, Eisner GM, Slotkoff LM. Effects of PGE2 on electrolyte and fluid secretion in the canine kidney: Evidence for a direct tubular effect. Can J Physiol Pharmacol 1979; 27: 1148-1152. 3. Shea-Donohue T, Myers L, Castell DO, Dubois A. Effects of prostacyclin on the gastric response to a water load. Advances in Prostaglandin and Thromboxane Research 1979; 8: 15571558. 4. Shea-Donohue T, Myers L, Castell DO, Dubois A. Effects of prostacyclin on gastric emptying and secretion in rhesus monkeys. Gastroenterology 1980; 78: 1476 -1479. 5. Shea-Donohue T, Nompleggi D, Dubois A. Effect of a prostaglandin F2α analog on gastric emptying and secretion in rhesus monkeys. J Pharmacol Exp Ther 1981; 219: 287-289. 6. Shea-Donohue T, Nompleggi D, Myers L, Castell DO, Dubois A. A comparison of the effects of prostacyclin and the 15(S)-15 methyl analogs of PGE2 and PGF2α on gastric parietal and non-parietal secretion. Dig Dis Sci 1982; 27: I7-22. 7. Shea-Donohue T, Nompleggi D, Myers L, Dubois A. A prostaglandin endoperoxide analog increases gastric emptying and suppresses gastric secretion in rhesus monkeys. J Pharmacol Exp Ther 1982; 222: 379-382. 8. Shea-Donohue T, Adams N, Arnold J, Dubois A. Effects of met-enkephalin and naloxone on gastric emptying and secretion in rhesus monkeys. Am J Physiol 1982; 222: G196-G900. 9. Shea-Donohue T, Danquechin-Dorval E, Montcalm E, El-Bayar H, Durakovic A, Conklin JJ, Dubois A. Alterations in gastric mucus secretion in rhesus monkeys following exposure to ionizing irradiation. Gastroenterology 1985; 88: 685-690. 10. El-Bayar H, Steel L, Montcalm E, Danquechin-Dorval E, Dubois A, Shea-Donohue T: The role of endogenous prostaglandins in the regulation of gastric secretion in rhesus monkeys. Prostaglandins 1985;30:401-419. 11. Shea-Donohue T, Steel L, Montcalm E, Dubois A. Gastric protection by sucralfate: Role of mucus and prostaglandins. Gastroenterology 1986;91:660-666. 12. Hirszel P, Shea-Donohue T, Chakrabarti E, Montcalm E, Maher J. The role of the capillary wall in restricting diffusion of macromolecules. A study of peritoneal clearance of dextrans. Nephron 1987;49:58-61. 13. Montcalm E, Shea-Donohue T. Effect of inhibition of leukotrienes on gastric function in rhesus monkeys. In: Roberto Levi and Robert D. Krell, eds. Biology of the Leukotrienes. Annals of the New York Academy of Sciences, 1988; pp 436-438. 14. Shea-Donohue T, Montcalm E, Steel L, Dubois A. Role of prostaglandins and damage in aspirin-induced changes in gastric function in primates. Gastroenterology 1990;98:284-292. 15. Touzeau PL, Shea-Donohue T. Kappa agonists inhibit gastric emptying but not gastric acid secretion in rhesus monkeys. J Pharmacol Exp Ther 1990;253:1010-1016.
Terez Shea-Donohue, PhD., Page 10 of 19 . 16. Shea-Donohue T, Kandasamy A, Dubois A. Effects of a prostacyclin analog, U68,215, on gastric acid secretion, gastric emptying and systemic blood pressure in primates. J Pharmacol Exp Ther. 1992;260:1023-1027. 17. Montcalm-Mazzilli E, Shea-Donohue T. Effect of leukotriene D4 on gastric emptying and secretion in rhesus monkeys. J Pharmacol Exp Ther 1992; 262:850-854. 18. Sjogren R, Colleton C, Shea-Donohue T. Intestinal myoelectric response in two different models of acute enteric inflammation. Am J Physiol 1994; 267:G329-G337. 19. Goldhill J, Sanders K, Sjogren T, Shea-Donohue T. Changes in enteric neural regulation of smooth muscle in a rabbit model of small intestinal inflammation. Am J Physiol 1995; 268:G823G830. 20. Goldhill J, Morris S, Finkelman F, Shea-Donohue T. Neural control of mouse small intestinal longitudinal muscle: interactions with inflammatory mediators. J Pharmacol Exp Ther, 1995; 274:72-77. 21. Stojadinovic A, Kiang J, Smallridge R, Galloway R, Goldhill J, Shea-Donohue T. Heat shock protein induction protects against ischemia and reperfusion injury in the rat small intestine. Gastroenterology 1995; 109:505-515. 22. Frankel HL, Nguyen HB, Shea-Donohue T, Aiton LA, Ratigan BS, Malcolm DS. Diaspirin crosslinked hemoglobin is efficacious in gut resuscitation as measured by a GI tract probe. J Trauma, 1996, 40:231-241. 23. Finkelman FD, Shea-Donohue T, Goldhill J, Sullivan CS, Morris SC, Madden KB, Gause WC, Urban JF. Cytokine regulation of host defense against parasitic gastrointestinal helminths: lessons from studies in rodent models. Ann Rev Immunol, 1997 15: 505-533. 24. Stojadinovic A, Kiang JC, Ding X, Smallridge RC, Galloway RJ, Goldhill J, Shea-Donohue T. Induction of heat shock protein prevents tissue injury during acute inflammation of the rat ileum. Critical Care Medicine, 1997, 25:309-317. 25. Goldhill J, Shea-Donohue T, Ali N, Pineiro-Carrero V. Tachykinin-mediated intestinal contractility is increased in experimental ileitis. J Pharmacol Exp Ther, 1997, 282:1373-1378. 26. Shea-Donohue T, Goldhill J, Pineiro-Carrero V, Sjogren R. Role of sensory afferents in the in vivo myoelectric response to acute enteritis in the rabbit. Amer J Physiol, 1997, 273:G447-G455. 27. Goldhill J, Morris S, Maliszewski C, Urban JF, Funk CD, Finkelman F, Shea-Donohue T. Interleukin-4 modulates cholinergic neural control of mouse small intestinal longitudinal muscle. Amer J Physiol, 1997, 272:G1135-G1140. 28. Urban JF, Rayer R, Sullivan CS, Goldhill J, Shea-Donohue T, Madden KB, Morris SC, Katona I, Gause WC, Ruff M, Finkelman FD. Local Th1 and Th2 responses to parasitic infection in the intestine: regulation by INF-gamma and IL-4. Veterinary Immunol and Immunopathol 1996, 54:337-344. 29. Stojadinovic A, Smallridge RJ, Shea-Donohue T. Antiinflammatory effects of U74389 in a rat model of intestinal ischemia/reperfusion injury. Critical Care Medicine 1999, 27:764-770. 30. Tavaf-Motamen H, Miner TJ, Starnes BE, Shea-Donohue T. Nitric oxide mediates acute lung injury by modulation of inflammation. J Surg Res 1998, 78:137-142. 31. Eror A, Stojadinovic A, Starnes BW, Makrides S, Tsokos G, Shea-Donohue T. Antinflammatory effects of soluble complement receptor type 1 promote rapid recovery of ischemiareperfusion in rat small intestine. Clinical Immunology 1999, 90:266-275. 32. Goldhill J, Stojadinovic A, Kiang JC, Smallridge RC, Shea-Donohue T. Hyperthermia prevents functional, histological and biochemical abnormalities induced during ileitis. Neurogastroenterol Motility 1999, 11:69-76. 33. Miner T, Tavaf-Motamen H, Stojadinovic A, Shea-Donohue T. Repeated episodes of
Terez Shea-Donohue, PhD., Page 11 of 19 . ischemia/reperfusion protect against rat small intestinal mucosal injury. J Surg Res 1999, 82:1-10. 34. Hosseini J, Goldhill J, Bossone C, Pineiro-Carrero V, Shea-Donohue T. Progressive changes in cholinergic and tachykinin-mediated smooth muscle contractility in a rat model of colitis. Neurogastroenterol. Motility 1999, 11:347-356. 35. Conner C, Gallagher C, Miner T, Tavaf-Motamen H, Wolcott K, Shea-Donohue T. Neutrophil priming state predicts capillary leak after gut ischemia in rats. J Surg Res 1999, 84:24-30. 36. Ward DW, Lawson S, Galagher C, Conner C, Shea-Donohue T. Sustained nitric oxide production via l-arginine administration ameliorates effects of intestinal ischemia-reperfusion. J Surg Res 2000, 89:13-19. 37. Bossone C, Hosseini JM, Pineiro-Carrero V, Shea-Donohue T. Alterations in spontaneous contractions in vitro following repeated inflammation of rat distal colon Am J Physiol 2001, 280: G949-G957. 38. Fleming, SD, Toratani S, Shea-Donohue T, Kashiwabara Y, Vogel SN, Metcalf ES. Pro- and anti-inflammatory gene expression in the murine small intestine and liver after chronic exposure to alcohol. Alcohol Clinical and Experimental Research. 2001, 25:579-590. 39. Shea-Donohue T, Sullivan CM, Finkelman F, Madden KB, Morris SC, Goldhill J, Urban JF. Role of interleukin-4 in Heligmosomoides polygyrus induced alterations in murine intestinal epithelial cell function. J. Immunol 2001, 167:2234-2239. 40. Zhao A, Pinerio-Carrero V, Shea-Donohue T. Colitis-induced alterations in adrenergic control of circular smooth muscle in rats. J Pharmacol Exp Ther 2001, 299:768-774. 41. Rehrig S, Fleming SD, Anderson J, Gutheridge JM, Rakstang J, McQueen C, Holers M, Tsokos G, Shea-Donohue T. Complement inhibitor, Crry-Ig, attenuates intestinal damage after the onset of mesenteric ischemia/reperfusion injury in mice. J Immunol, 2001,167:5921-5927. 42. Fleming SD, Starnes BW, Kiang J, Stojadinovic A, Toskos GC, McQueen C, Shea-Donohue T. Heat stress protection against mesenteric ischemia/reperfusion-induced alterations in intestinal mucosa in rats. J Appl Physiol, 2002, 92:2600-2607. 43. Lawson S, Ward DT, Conner WC, Gallagher C, Shea-Donohue T. Diabetes: a causative factor is systemic capillary leak. J Surg Res, 2002, 105(2):95-101. 44. Fleming SD, Shea-Donohue T, Gutheridge JM, Kulik L, Waldschmidt, Gipson MG, Tsokos GC, Holers VM. Mice deficient in complement receptors 1 and 2 lack a tissue injury-inducing subset of the natural antibody repertoire. J Immunol, 2002, 169(4):2126-2133. 45. Madden KB, Whitman L, Sullivan C, Gause WC, Urban JF Jr., Katona IM, Finkelman FD, Shea-Donohue T. Role of Stat6 and mast cells in IL-4- and IL-13-induced alterations in murine intestinal epithelial cell function. J. Immunol, 2002, 169: 4417-4422. 46. Fleming SD, Lambris JD, Shea-Donohue T, Tsokos G. C5 is critical for the mesenteric ischemia/reperfusion-induced local and remote organ injury. Clinical Immunology 2003, 106 (1):5564. 47. Swiecki C. Stojadinovic A., Anderson J, Zhao A, Dawson H, Shea-Donohue T. Effect of hyperglycemia and nitric oxide synthase (NOS) inhibition on heat tolerance and induction of heat shock protein 72kda (HSP-72) in vivo. American Surgeon, 2003, 69(7):587-92. 48. Fleming SD, Mastellos D, Karpel-Massler G, Shea-Donohue T, Lambris JD, Tsokos G C5a causes limited, polymorphonuclear cell-independent, mesenteric ischemia/reperfusion-induced injury. 2003, Clinical Immunology 108:263-273 49. Zhao A, McDermott J, Urban JF, Gause W, Madden KB, Au Yeung K, Morris SC, Finkelman FD, Shea-Donohue T. Dependence of IL-4, IL-13 and nematode induced alterations in murine small intestinal smooth muscle contractility on Stat6 and enteric nerves. J. Immunol 2003, 171:948954.
Terez Shea-Donohue, PhD., Page 12 of 19 . 50. Zhao A, Shea-Donohue T. Activation of protease-activated receptor-2 induces contraction of murine small intestine through neurokinin receptors. Am J Physiol 2003, 285(4): G696-G703. 51. Shea-Donohue T, Urban JF Jr. Gastrointestinal Parasite and Host Interaction. Current Opinion in Gastroenterology 2004, 20(1), pp3-9. 52. Mawe G, Collins S, Shea-Donohue T. Changes in enteric neural circuitry and smooth muscle in the inflamed and infected gut. Neurogastroenterol Motil. 2004, April 16 Suppl 1:133-6. 53. Madden K, Au Yeung K, Zhao A, Gause W, Finkelman FF, Katona IM, Urban JF Jr. SheaDonohue T. Enteric nematodes induce stereotypic STAT6-dependent alterations in intestinal epithelial cell function. J Immunol 2004, 172(9):5616-21. 54. Finkelman FD, Shea-Donohue T, Morris SC, Gildea L, Strait R, Madden KB, Schopf L, Urban JF Jr. Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites. Immunological Reviews 2004, 201: 139-155. 55. Anderson J, Fleming S, Rehrig S, Tsokos G, Basta M, Shea-Donohue T. Intravenous immunglobulin attenuates mesenteric ischemia-reperfusion injury. Clin Immunol 2005, 114:137146. 56. Dawson HD, Beshah E, Nishi S, Solano-Aguilar G, Zhao, A, Madden K, Dubey JP, SheaDonohue T, Lunney JK, Urban JF Jr. Localized multi-gene expression patterns support an evolving Th1/Th2-like paradigm in response to infection with Toxoplasma gondii and Ascaris suum. Infection and Immunity 2005, 73:1116-1128. . 57. Au Yeung K, Smith A, Zhao A, Madden KB, Elfrey J, Sullivan C, Levander O, Urban JF, and Shea-Donohue T. Impact of vitamin E or selenium deficiency on helminth-induced alterations in murine intestinal function. J. Exp. Parasitology 2005, 109: 201-208 58. Smith A, Madden KB, Au Yeung K, Zhao A, Elfrey J, Finkelman FD, Levander O, SheaDonohue T, Urban JF Jr. Effect of selenium and/or vitamin E deficiencies on Heligmosomoides polygyrus infections in mice. J. Nutrition 2005, 135: 830-836. 59. Zhao A, Morimoto A, Dawson H, Elfrey J, Madden KB, Gause WC, Min B, Finkelman FD, Urban JF, Shea-Donohue T. Immune regulation of protease-activated receptor-1 expression in murine small intestine during Nippostrongylus brasiliensis infection. Journal of Immunology 2005, 175(4):2563-2639. 60. Shea-Donohue T, Cook IJ, de Giorgio R, Tonini M, Dent J, Costa M, Grundy D, Sanders KM, Schemann M, Smith TK, Brookes SJ; the varenna group. A teaching module on irritable bowel syndrome. Neurogastroenterol Motil. 2005 Oct;17 Suppl 3:20-40. 61. Costa M, Sanders KM, Schemann M, Smith TK, Cook IJ, de Giorgio R, Dent J, Grundy D, Tonini M, Shea-Donohue T, Brookes SJ; the varenna group. A teaching module on cellular control of small intestinal motility. Neurogastroenterol Motil. 2005 Oct;17 Suppl 3:4-19. 62. Brookes SJ, Cook IJ, Costa M, de Giorgio R, Dent J, Grundy D, Sanders KM, Schemann M, Shea-Donohue T, Smith TK, Tonini M; the varenna group. Education project for pathophysiology of gastrointestinal motility. Neurogastroenterol Motil. 2005 Oct;17 Suppl 3:2-3. 63. Fasano A, Shea-Donohue T. The role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases. Nature Clinical Practice Gastroenterology and Hepatology, 2005 2(9):416-22. 64. Morimoto M, Morimoto M, Zhao A, Madden KB, Dawson H, Finkelman FD, Mentink-Kane M, Urban JF, Wynn T, Shea-Donohue T. Functional importance of regional differences in localized gene expression of receptors for IL-13 in murine gut. Journal of Immunology 2006 176(1):491-495. 65. Zhao A, Urban JF Jr., Morimoto M, Elfrey JE, Madden KB, Finkelman FD, Shea-Donohue T. Contribution of 5-HT(2A) receptor in nematode infection-induced murine intestinal smooth muscle hypercontractility. Gastroenterology 2006 Aug;131(2):568-78.
Terez Shea-Donohue, PhD., Page 13 of 19 . 66. Antalis T, Shea-Donohue T, Vogel S, Sears C, Fasano A. Protease functions in intestinal mucosal pathobiology. 2007, Nature Clinical Practice Gastroenterology and Hepatolog , 393-402. 67. Zhou P, Li E, Shea-Donohue T, Singer SM. Tumor necrosis factor contributes to protection against Giardia lamblia infection in mice. Parasite Immunol, 2007, 29:367-374. 68. Urban JF, Steenhard N, Solano-Aguilar G, Dawson H, Iweala O, Nagler CR, Noland G, Kumar N, Anthony RM, Shea-Donohue T, Gause WC. Infection with parasitic nematodes confounds vaccination efficacy. Veterinary Parasitology 2007 148(1):14-20. 69. Scanlan B, Tuft B, Elfrey JE, Smith A, Zhao A, Morimoto M, Chmielinska J, Tejero-Taldo MI, Mak IT, Weglicki WB, Shea-Donohue T. Intestinal Inflammation Caused by Magnesium Deficiency Alters Basal and Oxidative Stress-Induced Intestinal Function. Molecular and Cellular Biochemistry 2007, 306(1-2): 59 70. Li E, Zhao A, Shea-Donohue T, Singer S . Mast cell mediated changes in smooth muscle contractility during mouse giardiasis. Infection and Immunity 2007 75(9):4514-8. 71. Shea-Donohue T, Thomas KE, Cody MJ, Zhao A, DeTolla LJ, Kopydlowski KM, Fukata M, Lira SA, and Vogel SN. Mice deficient in the CXCR2 ligand CXCL1 (KC/GRO-α) exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis. Innate Immunity 2008, 14 (2):117-124. 72. Lammers KM, Lu R, Brownley J, Lu B, Gerard C, Thomas K, Rallabhandi P, Shea-Donohue T, Tamiz A, Alkan S, Netzel-Arnett S, Antalis T, Vogel SN, Fasano A. Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3. Gastroenterology 2008, 135(1):194-204. 73. Zhao A, Urban JF, Anthony AM, Sun R, Stiltz J, van Rooijen N, Wynn T, Gause WC, and SheaDonohue T. Th2 cytokine-induced alterations in intestinal smooth muscle function are dependent on alternatively activated macrophages. Gastroenterology, 2008, 135(1):217-225. 74. Sutton TL, Zhao A, Madden KB, Elfrey JE, Tuft BA, Sullivan CA, Urban, JF, and Shea-Donohue T. Anti-inflammatory Mechanisms of Enteric Heligmosomoides polygyrus Infection on TNBS-Induced Colitis in a Murine Model. Infection and Immunity, 2008 14(2): 114-124.. 75. Shea-Donohue T and Zhao A. Immune Regulation of Gut Function: Role of Th2 Cytokines and Their Receptors. Journal of Gastroenterology and Hepatology 2008, 4(2):73-76. 76. Morimoto M, Zhao A, Sun R, Stiltz J, Madden KB, Mentink-Kane M, Ramalingam T, Wynn TA, Urban JF, Shea-Donohue T. IL-13 Receptor 2 Regulates the Immune and Functional Response to Nippostrongylus brasiliensis infection. Journal of Immunology 2009, 183(3):1934-1939. 77. Tripathi A, Lammers KM, Goldblum S, Shea-Donohue T, Netzel-Arnett S, Buzza MS, Antalis TM, Vogel SN, Zhao A, Yanga Shiqi, Marie-Claire Arriettac,. Meddings JB, Fasano A. Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2. Proc Nat Acad Sci 2009, 106(39):16799-804. 78. Choi KM, Kashyap PC, Dutta N, Stoltz GJ, Ordog T, Shea Donohue T, Bauer AJ, Linden DR, Szurszewski JH, Gibbons SJ, Farrugia G. CD206-positive M2 macrophages that express heme oxygenase-1 protect against diabetic gastroparesis in mice. Gastroenterology 2010, 138(7):2399-409 79. Shea-Donohue T, Urban JF, Notari L, Zhao A. Immune Regulation of Epithelial Cell Function: Implications For GI Pathologies. Int Diary J [Epub 12/29/09]. 80. Buzza MS, Netzel-Arnett S, Shea-Donohue T, Zhao A, Lin CY, List K, Szabo R, Fasano A, Bugge TH, Antalis TM. Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine. Proc Nat Acad Sci , 2010,107(9):4200-5. 81. Shea-Donohue T, Notari L, Stiltz J, Sun R, Madden KB, Urban JF, Zhao A. Role of enteric nerves in immune-mediated changes in protease activated receptor 2 effects on gut function. Neurogastroenterology and Motility, 2010 138(7), 1138-e291
Terez Shea-Donohue, PhD., Page 14 of 19 . 82. Shea-Donohue T, Stiltz J, Zhao A, Notari L. Mast cells. Current Gastroenterology Reports 2010 12(5), 349-57. 83. Greenspon J, Li R, Xiao L, Rao JN, Sun R, Strauch ED, Shea-Donohue T, Wang JY, Turner DJ. Sphingosine-1-Phosphate Regulates the Expression of Adherens Junction Protein E-Cadherin and Enhances Intestinal Epithelial Cell Barrier Function. Dig Dis Sci 2011, 56(5):1342-53. 84. Zhao A., Urban JF, Sun R, Stiltz J, Morimoto M, Notari L, Madden KB, Yang Z, Grinchuk V, Ramalingam TR, Wynn T, Shea-Donohue T. Critical role of IL-25 in nematode infection-induced alterations in intestinal function. J Immunology 2010, 185(11):6921-9. 85. Shea- Donohue T, Fasano A, Smith A, Zhao, A. Enteric Pathogens and Gut Function: Role of Cytokines and STATs. Gut Microbes 2010, 1(5):316-324. 86. Smith A, Botero A, Shea-Donohue T, Urban JF. The pathogenicity of an enteric Citrobacter rodentium infection is enhanced by deficiencies in the antioxidants selenium and vitamin E. Infection Immunity 2011, 79(4):1471-8. 87. Netzel-Arnett S, Buzza MS, Shea-Donohue T, Désilets A, Leduc R, Fasano A, Bugge TH, Antalis TM. Matriptase protects against experimental colitis and promotes intestinal barrier recovery. Inflamm Bowel Dis 2012 18(7): 1303-1314. 88. Yang Z, Grinchuk V, Ip SP, Che CT, Fong HS, Lao L,. Wu JC, Sung JJ, Berman B, Shea-Donohue T, Zhao A. Anti-inflammatory activities of a Chinese herbal formula IBS-20 in vitro and in vivo. Evidence-Based Complementary and Alternative Medicine, 2012: Epub Feburary 22. 89. Luzina I, Keegan A, Heller N, Rook G, Shea-Donohue T, Atamas S. Regulation of inflammation by interleukin-4: a review of "alternatives”. J. Leukocyte Biol 2012, Epub July 13. 90. Shea-Donohue T, Notari L, Sun R, Zhao A. Mechanisms of smooth muscle responses to inflammation. Neurogastroenterology and Motility 2012, 24(9): 1365-1378. 91. MacVittie TJ, Bennett A Booth C , Garafalo M, Tudor G , Ward A, Shea-Donohue T, Gelfond D, McFarland E, Jackson, W, Lu W, Farese AM. The prolonged gastrointestinal syndrome is rhesus macques: the realtionsip between gastrointestinal, hematopoietic, and delayed mulit-organ sequelae following acute, potentially lethal, partical body irradiation. Evidence of delayed gastrointestinal syndrome in high dose irradiated mice. Health Physics 2012, 103(4): 427-453. 92. Booth C, Tudor G, Tonge N, Shea-Donohue T, MacVittie TJ. Evidence of delayed gastrointestinal syndrome in high-dose irradiated mice. Health Physics 2012, 103(4): 400-410. 93. MacVittie TJ, Farese AM, Bennett A, Gelfond D, Shea-Donohue T, Greg Tudor G, Booth C, McFarland E, Jackson William. The acute gastrointestinal sub-syndrome of the acute radiation syndrome: a rhesus macque model. Health Physic 2012, 103(4): 411-426. 94. Vanuytsel T, Senger S, Fasano A, Shea-Donohue T. Major Signaling Pathways in Intestinal Stem Cells. Biochim Biophys Acta 2012 Epub August 16. 95. McLean LP, Shea-Donohue T, Cross RK. Vedolizumab for the treatement of ulverative colitis and Crohn’s disease. Immunotherapy 2012, 4(9):883-898 96. Ramesh D, Gamage TF, Vanuytsel T, O’Neal ST, Owens RA, Abdullah RA, Cravatt BF, SheaDonohue T, Lichtman A. Dual inhibition of endocannabinoid catabolic enzymes produces enhanced anti-withdrawal effects in morphine-dependent mice. Neuropsychopharmacology 2013 (Epub, Jan 3). 97. Faherty C, Harper JM, Shea-Donohue T, Barry R, Fasano A, and. Nataro JP. Chromosomal and Plasmid-Encoded Factors of Shigella flexneri Induce Secretogenic Activity Ex Vivo. PLOS ONE 2012; 7(11) 98. Yang Z, Sun R, Grinchuk V, Fernandez Blanco JA, Notari L, Bohl J, McLean L, Ramalingam T, Wynn TA, Urban JF, Shea-Donohue T, Zhao A IL-33-induced Alterations in Murine Intestinal
Terez Shea-Donohue, PhD., Page 15 of 19 . Function and Cytokine Responses Are MyD88-, STAT6-, and IL-13-dependent. Am J Physiol Gastrointest Liver Physiol, 2013, 304(4):G381-389 99. Yang Z, Sun R, Grinchuk V, Fernandez Blanco JA, Notari L, Bohl J, McLean L, Ramalingam T, Wynn TA, Urban JF, Shea-Donohue T, Zhao A . IL-33-induced Alterations in Murine Intestinal Function and Cytokine Responses Are MyD88-, STAT6-, and IL-13-dependent. Am J Physiol Gastrointest Liver Physiol, 2013, 304(4):G381-389 100. Yang Z, Grinchuk V, Urban JF, Bohl J, Sun R, Notari L,Yan S, Ramalingam T, Keegan AD, Wynn TA, Shea-Donohue T, Zhao A. Novel Role of Macrophages as IL-25/IL-33-Responsive Cells in the Induction of Type 2 Immunity. PLOS One. 2013, 8(3):e59441. 101. Yang, Z, Grinchuk V, Smith A, Qin B, Bohl J, Sun R, Notari L, Zhang Z, Sesaki H, Urban JF, Shea-Donohue T, Zhao A. Enteric nematode Infection-induced immunotherapy against obesity and the associated metabolic Syndrome. Infection and Immunity. 2013, 81(6):1905-14. 102. Zhao A, Yang Z, Sun R, Grinchuk V, Netzel-Arnett S, Notari L, Bohl J, Madden KB, Urban JF, Antalis TM, Shea-Donohue T. SerpinB2 is critical for Th2 Immunity against enteric nematode infection J. Immunol. 2013 90(11):5779-87. PMID:23630350 [PubMed - in process] 103. Smith AD, Cheung L, Beshah E, Shea-Donohue T, Urban JF. Selenium Status Alters the Immune Response and Expulsion of Adult Heligmosomoides bakeri Worms in Mice. Infection Immunity 2013 81(7):2546-2553. PMID: 23649095 [PubMed - in process]. 104. Alaish SM, Timmons J, Smith A, Buzza M, Murphy E, Zhao A, Turner DJ, Shea-Donohue T, Nataro J, Antalis T, Cross A, Dorsey S. Candidate genes for limiting cholestasis injury identified by gene expression profiling. Physiological Reports (in press). 105. McLean LP, Cross RK, Shea-Donohue T. Combined blockade of IL-17A and IL-17F may prevent the development of experimental colitis. Immunotherapy 2013 Sep;5(9):923-5. 106. Smith A, Timmons J, Greenspon J, Eyvazzadeh D, Murphy E, Shea-Donohue T, Cirimotich S, Mongodin E, Zhao A, Fasano A, Nataro J, Cross A. Gut microbiota, tight junction protein expression, intestinal resistance, bacterial translocation and mortality following cholestasis depend on the genetic background of the host. 2013 Gut Microbes (in press). 107. Notari L, Riera D, Sun R, Bohl J, Sullivan C, Madden K , van Rooijen N, Vanuytsel T, Urban JF, Zhao A, Shea-Donohue T. Role of macrophages in altered epithelial function during a type 2 immune response induced by enteric nematode infection.2014, Plos One (in press). 108. 109. Sun R, Notari L, Vanuystsel, T, Madden K, Bohl, J, Ramalingam T, Wynn J, Urban JF, Zhao A, Shea-Donohue T. IL-13RÎą1-dependent responses in the intestine are critical to parasite clearance (submitted). 110. Shea-Donohue T , Zhao A, Antalis TM. SerpinB2 Mediated Regulation of Macrophage Function during Enteric Infection. Gut Microbes 2014 (in press) Non-Peer Reviewed Articles 1. Stojadinovic A, Miner TJ, Tavaf-Motamen H, Shea-Donohue T. Mucosal healing following ischemia/reperfusion injury of rat small intestine: role of mucus and lipid peroxidation. Surgical Forum, 1997, vol XLVII: 223-226. 2. Tavaf-Motamen H, Miner T, Shea-Donohue T. Intestinal ischemia/reperfusion is a systemic phenomenon and is not mediated by local factors such as neutrophil infiltration. Surgical Forum, 1997, vol XLVII: 26-28. 3. Starnes BW, Tavaf-Motamen H, Miner T, Kiang J, Shea-Donohue T. Glutamine improves function, but does not prevent mucosal injury, following ischemia reperfusion of rat small intestine. Surgical Forum, 1997, vol XLVII: 22-24.
Terez Shea-Donohue, PhD., Page 16 of 19 . Book Chapters 1. Dubois A, Shea-Donohue PT, Nompleggi D. Gastric emptying, prostaglandins and cytoprotection. In: Harmon J, ed. Basic Mechanisms of Gastrointestinal Mucosal Cell Injury and Protection. Williams and Wilkins Co., Chapter 17, 1981: 243-247. 2. Shea-Donohue PT, Adams N, Arnold J, Dubois A. Role of endogenous opiates on the gastric response to various caloric meals. In: Martin Wienbeck, ed.. Motility of the Digestive Tract. Raven Press, 1981: 127-129. 3. Shea-Donohue T. Role of acid and tissue prostaglandins in the production of gastric mucosal damage. In: Szabo S, ed., Ulcer Disease: New Aspects of Pathogenesis and Pharmacology. CRC Press, Inc. 1989; pp157-166. 4. Shea-Donohue T. Methods for Assessing Gastric Secretion. In: Methods in Gastrointestinal Pharmacology: A Handbook. Gaginella TS, Ed. 1996, pp-1-35. 5. Urban JF, Mansfield LS, Shea-Donohue T, Gause W, Finkelman F. Mechanisms of intestinal immunity to nematode parasites and the consequences to invasion by opportunistic bacteria. In: Immunomodulation of the Gastrointestinal Mucosa. PJ Heidt, JC Cebra, VD Rusch, D. Van der Waaij, RI Walker, Eds., Herborn Litterae, 1998, pp.59-68. 6. Urban JF, Shea-Donohue T, Gause WC, Finkelman FD. Cytokine immunomodulation of infectious diseases. In Handbook of Immune Modulating Agents. TF Kresina, Ed., Marcel Dekker Inc., New York, 1998, pp 169-185. 7. Shea-Donohue T, Anderson J, Swiecki C. Ischemia reperfusion injury. In Combat Medicine: Basic and Clinical Research in Military Trauma and Emergency Medicine. Eds: GC. Tsokos, J Atkins. 2003, pp219-248. 8. Fasano A. and Shea-Donohue T. Basics of GI physiology and mucosal immunology. In Probiotics in Pediatric Medicine Eds: Sonia Michael and Philip Sherman, 2009. Invited Presentations (since 1998) Local 1. March, 1999, “Role of IL-4 in the intestinal response to helminth infection,” Molecular and Cell Biology Seminar Program, USUHS, Bethesda, MD 2. February and March, 2000 “Inflammatory Bowel Disease,” Continuing education program for State Department Physicians, , USUHS, Bethesda ,MD 3. November, 2000, “The many facets of mesenteric ischemia/reperfusion injury,” Guilford Pharmaceuticals, Baltimore, MD 4. August, 2002, “Effects of magnesium deficiency on gut function,” George Washington University School of Medicine, Washington, DC 5. April, 2003 “The impact of polarized cytokine profiles on colonic function”, University of Maryland School of Medicine, Baltimore, MD 6. March 8, 2005, “Tales from the crypts” Department of Physiology, University of Maryland, Baltimore, MD 7. April 29, 2005, “The impact of polarized cytokine profiles on gut function”. Department of Biology, Georgetown University, Washington, DC 8. March, 2005, “Pathogenesis of IBD” IBD Working Group, University of Maryland, Baltimore, MD 9. May, 2005, “Immune regulation of gut function” Digestive Diseases Center, George Washington University School of Medicine, Washington, DC 10. May, 2005. “Lessons learned from animal models of IBD”, Division of Gastroenterology, Department of Medicine, University of Maryland School of Medicine,
Terez Shea-Donohue, PhD., Page 17 of 19 . 11. November, 2005, “The ABC’s of genetics in IBD”, Conference on Advances in IBD: A Case Based-Approach, Baltimore, MD 12. January, 2008, “Alternatively Activated Macrophages and Immune regulation of Gut Function”, Inflammatory Research Group, University of Maryland School of Medicine, Baltimore, MD 13. January, 2008, “Macrophages and Immune regulation of Gut Function”, Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 14. November, 2008, Diabetes, Obesity and Immune regulation of Gut Function”, Department of Medicine, Uniformed Services University of the Health Sciences. 15. November, 2009. “Recent advances in IL-13 and Gut Function”, NIAID, Immunopathogenesis Lab. 16. November, 2011. “Another piece of PAI2” Inflammatory Research Group, University of Maryland School of Medicine, Baltimore, MD. 17. May, 2012. “Immune Control of Intestinal Stem Cell Function” Inflammatory Research Group, University of Maryland School of Medicine, Baltimore, MD. 18. December, 2013. “Immune Regulation of Proteolytic Pathways” Department of Microbiology and Immunology Seminar series, University of Maryland School of Medicine, Baltimore, MD.
National 1. November 1998, University of South Dakota, Vermillion, SD “Th2 cytokines and gastrointestinal function,” 2. January, 1999, Keystone Symposium on Type 2 Cytokines in Allergy and Helminth Infections, Lake Tahoe, NV “IL-4 regulation of intestinal physiology,” 3. October, 1999, Department of Medicine, Medical College of Virginia, Richmond, VA “Role of nitric oxide in regulation of colonic motility in diabetes and IBD,” 4. September, 2000, University of South Dakota, Vermillion, SD “Th1 and Th2 cytokines - opposite ends of the spectrum in gastrointestinal inflammation,” 5. July, 2001, American Association of Veterinary Pathologists, Boston, MA “Tales from the crypts: Role of Th2 cytokines in parasite-induced alterations in gut function,” 6. January, 2002, Millenium Pharmaceuticals, Cambridge, MA. “Lessons learned from experimental models of colitis,” 7. May, 2002, Meet the Investigator, Digestive Disease Week “Immune-mediated alterations in gut function,” 8. October, 2002, Parasitology Symposia, Fancy Gap, VA “Nutritional modulation of enteric responses to helminth infection,” 9. February, 2003 Department of Physiology and Cell Biology, Reno, NV “Type 1 and type 2 cytokines: Effects on gut function”, 10. July, 2004, Center for IBD Research, University of Chicago, Chicago, IL “Cytokine profiles and immune mediated changes in smooth muscle function.” 11. May, 2007, Digestive Disease Week, Washington, DC “Impact of Inflammation on Gut Function: What makes is a Memorable Response”. 12. November, 2005, Division of Gastroenterology, Mt. Sinai Hospital, New York City, NY “Cytokine mediated alterations in smooth muscle function” 13. November, 2005, Department of Microbiology and Immunology, Kansas State University, KS “Mechanisms of immune-mediated changes in gut function” 14. February, 2006, Department of Medicine, Division of Gastroenterology, University of Texas Medical School, Galveston, TX, “Helminths and immune mediated changes in smooth muscle
Terez Shea-Donohue, PhD., Page 18 of 19 . function” 15. November, 2006. Department of Neuroscience, University of Oklahoma. Tales from the Crypts: Mechanisms of Immune Regulation of Gut Function”, 16. March, 2007, Department of Anatomy, University of Vermont. “Dangerous Liaisons: Mechanisms of immune regulation of gut function”, 17. April, 2008, Mayo Clinic “Dangerous Liaisons: Mechanisms of immune regulation of gut function”, 18. September, 2008 Reno Nevada: “Mechanisms of cytokine mediated alterations in smooth muscle function”. 19. October, 2008, University of Illinois (Chicago): “Immune regulation of epithelial cell function during Th2 responses”. 20. January 6, 2009, NIAID Laboratory of Parasitic Diseases: “Regulation of the biological activity of IL-13”. 21. February 3, 2009, NIH Radiation Countermeasures Meeting: “Novel therapy for post-irradiation insult to gut mucosa in non-human primates”. 22. March 24, 2009, NIDDK sponsored symposium entitled Organ Smooth Muscle: Development, Physiology and Pathology. “Mechanisms of immune regulation of smooth muscle function”. 23. August, 2010, American Motility and Neurogastroenterology Society Meeting, “Relevance of Animal Models of Inflammation to IBS”. 24. September, 2011, NIH sponsored symposium on Translational Approaches for Pharmacotherapy Development for Acute Diarrhea. “ Flexing the role of smooth muscle in acute diarrhea”. International 1. February, 1998, Little Brain, Big Brain, Victoria Australia “Remodeling of the enteric neural control of spontaneous smooth muscle contractility during inflammation of rat colon," 2. October, 2003, Little Brain Big Brain Conference, S’Agaro, Spain, “Cytokine receptor distribution and gut function,” 3. October, 2003, International Motility Symposium, Barcelona, Spain, “Impact of virus, bacteria, parasites on gastrointestinal function," 4. April, 2004, Ponce University School of Medicine, Ponce Puerto Rico “Immune regulation of gut function,” 5. March, 2006. Mucosal Inflammation Group, University of Calgary, Canada. “Immune Regulation of PAR in Helminth Infection,” 6. April, 2006, Symposium on Health Aspects of Calcium and Magnesium in Drinking Water. Sponsored by the World Health Organization (WHO). “Magnesium and the Immune System”. 7. May, 2007, Invited Lecture, American Gastroenterology Association, Washington, DC. “Impact of Inflammation on Gut function, What Makes It a Memorable Response”, 8. September, 2007. International Symposium on Neurogastroenterology and Motility, Jeju Island, Korea “Mechanisms of Immune and Smooth Muscle Interactions”, 9. September, 2007, International Symposium on Neurogastroenterology and Motility, Jeju Island, Korea “Gut Inflammation and Motility, A Problem with Communication”, 10. November, 2007, “Update on Basic Science Research on Functional GI Disorders”, International Symposium on Traditional Chinese Medicine Approaches to Gastrointestinal Disorders, Baltimore, MD. 11. March, 2010, Functional Food Conference, Cork, Ireland “Immune regulation of epithelial cell function”.
Terez Shea-Donohue, PhD., Page 19 of 19 . 12. May, 2010, Invited Lecture American Gastroenterology Association, New Orleans, LA, “Effect of Age on Gastrointestinal Immune cells and Gut Function”. 13. November, 2010, Astrazeneca, Copenhagen, DN “IL-13 and Fibrosis”. 14. September, 2012, International Neurogastroeneterology and Motility Meeting, Bologna, Italy “ New insights on macrophages and mast cells”