8160e93a5ea046d28220adcd5c51daa8 by Larry Roberts

Navesh K. Sharma, DO, PhD Curriculum Vitae

Navesh K. Sharma, DO, PhD Assistant Professor, Department of Radiation Oncology Adjunct Assistant Professor, Department of Diagnostic Radiology and Nuclear Medicine Medical Director of Radiation Oncology, Kaufman Cancer Center, University of Maryland, Upper Chesapeake Health University of Maryland School of Medicine

Date December 23, 2013 Contact Information Navesh K. Sharma, DO, PhD University of Maryland, Upper Chesapeake Health Kaufman Cancer Center Department of Radiation Oncology 500 Upper Chesapeake Drive Bel Air, MD 21014, USA E-mail: nsharma@umm.edu Tel:

(443) 643-1873

Fax:

(443) 643-1521

Education 1995

B.S.

Biology (emphasis in genetics), Summa Cum Laude, St. Cloud State University, St. Cloud, MN

2000

Ph.D.

Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City, IA

2005

D.O.

Medicine, Kansas City University of Medicine and Biosciences – COM, Kansas City, MO

Post Graduate Education and Training 2001

Fellowship

H. B. Wallace Postdoctoral Fellowship Department of Anatomy and Cell Biology University of Iowa College of Medicine, Iowa City, IA

Navesh K. Sharma, DO, PhD 2006 Internship Mercy Catholic Medical Center Darby, PA

2008

Fellow

AACR/ASCO Methods in Clinical Cancer Research Workshop Vail, CO

2010 Residency

Department of Radiation Oncology (2006-10) Fox Chase Cancer Center Philadelphia, PA

2012

American Brachytherapy Society HDR Fellowship Seattle, WA

Fellow

Certifications

2006

Diplomate, National Board of Osteopathic Medical Examiners

2011

Diplomate, American Board of Radiology- Radiation Oncology

Medical Licensure 2006 2007

Unrestricted Medical Licensure- State of Pennsylvania (Active) Drug Enforcement Administration- Unrestricted Licensure (Active)

2010

Unrestricted Medical Licensure- State of Maryland (Active)

2010

Maryland Controlled Substances (Active)

Employment History

Primary Academic Appointment 2010- Present

Assistant Professor, Department of Radiation Oncology, UMSOM

2011- 2013

Associate Director, Radiation Oncology Residency Program, UMSOM

2013- Present

Medical Director, Department of Radiation Oncology, UCHS

2013- Present

Interim Director, Billing and Compliance, Department of Radiation Oncology, UMSOM

Secondary Academic Appointment 2011- Present

Assistant Professor, Department of Diagnostic Radiology and Nuclear Medicine, UMSOM

Navesh K. Sharma, DO, PhD Clinical Privileges 2010- Present

University of Maryland Medical Center, Baltimore, MD

2010- Present

Baltimore VA Medical Center, Baltimore, MD

2013- Present

Upper Chesapeake Medical Center, Bel Air, MD

Professional Memberships 1996- Present

American Association for Cancer Research

2001- Present

American Osteopathic Association

2006- Present

American Society for Radiation Oncology

2006- Present

American Society for Clinical Oncology

2006- Present

American Brachytherapy Society

2006- Present

Radiological Society of North America

2006- Present

Radiation Therapy Oncology Group

2010- Present

Alliance for Clinical Trials in Oncology (formerly Cancer and Leukemia Group B)

2011- Present

American College of Radiation Oncology

Honors and Awards

Undergraduate 11/1995

Graduated Summa cum Laude, St. Cloud State University, St. Cloud, MN

08/1997

Inducted into Sigma Xi National Science Honor Society

Graduate School

12/1998 11/2000 Medical School 05/2002-03

Young Investigator Research Award, American Association for Cancer Research, Palm Springs, CA Young Investigator Award, Society for Basic Urologic Research, Sanibel, FL Excellence in Biomedical Research Fellowship, Kansas City University of Medicine and Biosciences, Kansas City, MO

Navesh K. Sharma, DO, PhD

2002, 03, 04

Best Medical Student Research Award, Kansas City University of Medicine and Biosciences, Kansas City, MO

05/2005

Basic Science Research Award, Kansas City University of Medicine and Biosciences, Kansas City, MO

Residency

08/2008

Selected for ASCO/ACR Methods in Clinical Cancer Research Workshop, Vail, CO

07/2008-06/09

Chief Resident, Fox Chase Cancer Center, Philadelphia, PA

09/2008

Radiation Therapy Oncology Group Fellowship, Philadelphia, PA

04/2009

Young Oncologist Essay Award, American Radium Society, Vancouver, BC

07/2009

RSNA Roentgen Resident/Fellow Research Award

02/2010

ASTRO Abstract Award- Multidisciplinary Head and Neck Cancer Meeting, Chandler, AZ

Attending Physician 2011

Selected for American Brachytherapy Society HDR Fellowship

2012

Awarded Department of Radiation Oncology Seed Grant for Research

Clinical Activities Clinical Expertise Liver-Directed Therapy Gastrointestinal Malignancies Lymphoma and Leukemia Gynecological Malignancies Genitourinary Malignancies Head and Neck Malignancies Breast Malignancies Thoracic Malignancies Technical Expertise Transarterial Radioembolization/Selective Internal Radiation Therapy (SIRT) - leader of one of the largest programs in the country

Navesh K. Sharma, DO, PhD

Intensity Modulated Radiation Therapy (IMRT) Image Guided Radiation Therapy (IGRT) Stereotactic Radiosurgery (SRS) Stereotactic Body Radiation Therapy (SBRT) Total Body Irradiation (TBI) High Dose Rate (HDR) Gynecologic Brachytherapy Low Dose Rate (LDR) Prostate Brachytherapy Scope of Clinical Practice Large cancer medical center 300-350 patient consultations per year 300 patients treated per year Clinical Duties: 4 days/week, 12 months/year Clinical Trials National/International Protocol Principal Investigator STXO l 12 (FOXFIRE Global): Assessment of Overall Survival of FOLFOX6m plus SIR-Spheres Microspheres Versus FOLFOX6m Alone as First-Line Treatment in Patients with Non-Resectable Liver Metastases from primary Colorectal Carcinoma in a Randomized Clinical Study

2013- Present

Institutional Principal Investigator of National/International Protocols GCC 0654 H-28622: Randomized Comparative Study of FOLFOX6M Plus Sirspheres versus FOLFOX6M Alone as First Line Treatment in Patients With NonResectable Liver Metastases From Primary Colorectal Cancer

2011 -2013

2012- Present

RTOG 1114: Phase II Randomized Study of Rituximab, Methotrexate, Procarbazine, Vincristine, and Cytarabine With and Without Low-Dose WholeBrain Radiotherapy for Primary Central Nervous System Lymphoma

2012- Present

RTOG 1271: A Phase II/III trial of Neoadjuvant FOLFOX, with Selective Use of Combined Modality Chemoradiation versus Preoperative Combined Modality Chemoradiation for Locally Advanced Rectal Cancer Patients Undergoing Low Anterior Resection with Total Mesorectal Excision

Navesh K. Sharma, DO, PhD

Institutional Co- Investigator of National/International Protocols 2010 - Present

2011 - 2012 2011 -2012 2011 -2012 2011 -Present Teaching Service

RTOG 0724 - Phase III Randomized Study of Concurrent Chemotherapy and Pelvic Radiation Therapy with or without Adjuvant Chemotherapy in High-Risk Patients with Early-Stage Cervical Carcinoma Following Radical Hysterectomy RTOG 1010 -A Phase III Trial Evaluating the Addition of Trastuzumab to Trimodality Treatment of Her2-0ver expressing Esophageal Adenocarcinoma CALGB 50801 -Phase II Trial of Respond-Adapted Therapy based on Positron Emission Tomography (PET) for Bulky Stage I and Stage II Classical Hodgkin Lymphoma (HL) HO Rad Biodose -Radiation Biodosimetry in Patients Treated With A Single Dose of Radiation To Prevent Heterotopic Ossification RTOG 0848: Phase III Trial Evaluating both Erlotinib and Chemoradiation as Adjuvant Treatment for Patients with Resected Head of Pancreas Adenocarcinoma

The University of Iowa College of Medicine (50-60 students) 1996

Graduate Teaching Assistant, Dental Histology, University of Iowa, Iowa City, IA

1997

Graduate Teaching Assistant, Dental Gross Anatomy, University of Iowa, Iowa City, IA

1997

Graduate Teaching Assistant, Medical Neuroscience, University of Iowa, Iowa City, IA

2000- 01

Graduate Instructor, University of Iowa Student Athlete Tutoring Program, Iowa City, IA

Navesh K. Sharma, DO, PhD

Kansas City University of Medicine and Biosciences- COM (1-2 students per session) 2002- 05

Peer Tutor, Medical Pharmacology, Kansas City University of Medicine and Biosciences, Kansas City, MO

Clinical Teaching Duties (University of Maryland Medical Center) 2010- 2013

Attending Physician, inpatient/outpatient consults, outpatient clinic 1 resident, 10 hours/day, 4 days/week, 10-12 months/year

Medical Advisor, Radiation Oncology Medical Dosimetry Program, UM SOM 2011-Present Clinical Resident Lectures, UMSOM, Dept. of Radiation Oncology (15-20 attendees) Q & A on Breast Cancer-Breast Cancer: Jeopardy Sept 16, 2010 Nov 17, 2010

Management of Malignant Liver Lesions

Dec 20, 2010

Rectal Cancer Management

Mar 01 , 2011

SIRT Therapy and Clinical Applications

Mar 03, 2011

Wilms Tumor Management

May 11, 2011

Hodgkins Lymphoma Field Design

Jun 08, 2011

Non Hodgkins Lymphoma – Management and Field Design

Sep 07, 2011

Thoracic Oral Boards Review

Dec 05, 2011

GI Mock Orals- Dr. Benjamin Laser

Dec 07, 2011

Gyn Oral Board Review

Jan 30, 2012

GI Mock Orals- Dr. Elizabeth Nichols

Apr 02, 2012

Lymphoma Mock Orals- Dr. Grace Kim

Apr 12, 2012

GI Mock Orals- Dr. Randi Cohen

Apr 19, 2012

Gyn Mock Orals- Dr. Randi Cohen

Apr 26, 2012

Lymphoma Mock Orals- Dr. Randi Cohen

May 07, 2012

Hodgkin's Lymphoma Lecture

May 14, 2012

Non-Hodgkin’s Lymphoma

May 14, 2012

GI/Gyn Mock Orals- Dr. Geoffrey Neuner

Navesh K. Sha rma, DO, Ph D

May 16, 2012

Lymphoma Jeopardy

May 21, 2012

Lymphoma Field Design Lecture

Nov 11, 2012

Gyn Journal Club

Nov 21, 2012

Gyn Jeopardy

Dec 5, 2012

Lymphoma mock orals- Dr. Sarah Grabowski

Dec 10, 2012

Treatment film rounds

May 13, 2012

Non-Hodgkin's Lymphoma: Updates in Field Design and Management

May 15, 2013

Hodgkin's Lymphoma Update

May 19, 2013

Gyn Mock Orals- Dr. Grace Kim

May 19, 2013

Gyn Mock Orals- Dr. Zain Hussain

Radiobiology Lecture Series, UMSOM, Dept. of Radiation Oncology (10-15 attendees) Total Body Irradiation Effects

Dec 8, 2010 Mar 9, 2011

Review of Radiobiology for In-service exams

Dec 14, 2011

Effects of TBI on the developing fetus

Mar 13, 2013

Radiobiology Review: What's clinically relevant?

Resident Research Sponsorships/Mentorships, UMSOM, Dept. of Radiation Oncology Sarah Grabowski, MD Topic: The Efficacy of Selective Internal Radiation Therapy (SIRT) with Yttrium90 (Y90) is Enhanced When Given in Low Volume Disease and in Conjunction With Other Liver-Directed Therapies Result: Accepted for presentation at the American Society for Radiation Oncology Annual Meeting, Miami, FL, October 2011

2010-2011

2010- 2011

Elizabeth Nichols, MD Topic: Performance Status (PS), Number of Lesions and Interval from Metastatic Diagnosis to Treatment (IMDTT) Predict for Overall Survival (OS) in Patients Treated with Hepatic Transarterial Radioembolization (TARE) using Yttrium-90 (Y90) Microspheres. Result: Accepted for presentation at the American Society for Radiation Oncology Annual Meeting, Miami, FL, October 2011

Navesh K. Sharma, DO, PhD

Medical Student Mentoring 2012 2012-13

Duc Nguyen, BS (MS I) Topic: Low Dose RT plus modified Docetaxel, Cisplatin, 5-Fluorouracil (mDCF) Chemotherapy in the Treatment of Advanced Gastric/GE Junction Cancers: A Pilot Study Result: Awarded radiation oncology summer research fellowship and abstract presented at the American Society for Radiation Oncology Annual Meeting, Atlanta, GA, September 2013 Huma Chaudhry, BS (MSIII) Topic: 1. Association between k-Ras mutation status and outcomes in patients treated with radioembolization for metastatic colorectal cancer 2. The role of radiation therapy in pancreatic neuroendocrine malignancies Result: Both abstracts accepted for presentation at the American Society for Radiation Oncology Annual Meeting, Atlanta, GA, September 2013

Administrative Services National 2009- Present

ASTRO Radiation and Cancer Biology Committee- Examination Subcommittee

2009- 2011

ASTRO Emerging Technologies Committee- Evaluations Subcommittee

2009- Present

ASTRO Health Policy Council- Regulatory Subcommittee

2010- Present

Member, Gastrointestinal Core Committee, Alliance for Clinical Trials in Oncology

2011

Cancer and Leukemia Group B (CALGB) Radiation Oncology Committee, Quality Assurance Subcommittee

2011- Present

GI section reviewer, American College of Radiation Oncology - Practice Accreditation Program (ACRO-PAP)

2011- Present

GI disease site team leader, ACRO-PAP

2011- 2012

National Institutes of Health Rectal/Anal Cancer Task Force

2013- Present

ASTRO Payer Relations Committee (PRC)

Departmental (Radiation Oncology) 2010- Present

Residency Admission Committee Application reviewer (70-80 applications annually)

2010- Present

Brachytherapy Committee

2010- Present

Rad Onc Patient Database Development Committee (Leader)

Navesh K. Sharma, DO, PhD

2010- Present

Disease Specific Practice Guidelines- Esophagus (Co-Leader)

2010- Present

Disease Specific Practice Guidelines- Rectum (Co-Leader)

2010- Present

Disease Specific Practice Guidelines- Anus (Co-Leader)

2010- Present

Disease Specific Practice Guidelines- Lymphoma (Co-Leader)

2011- 2013

Radiation Oncology Residency Program (Associate Director)

2011- Present

IT Steering Committee (Physician Leader)

2011- Present

IT Committee (Co-Leader)

2011- Present

Medical Advisor, Radiation Oncology Medical Dosimetry Program

2012- Present

EMR Subcommittee (Physician Leader)

2013- Present

Radiation Oncology Billing and Compliance, Interim Director

Institutional (UMSOM) Committees 2010- Present

Technology Research Review Committee

20 1 0- Present

Cancer Research Committee

2011- Present

University of Maryland Dosimetry School Curriculum Committee

20 1 0- Present

University of Maryland Dosimetry School Advisory Committee

20 1 0- Present

American College of Surgeons accredited Cancer Committee

2012- Present

Institutional Review Board Consultant

2013- Present

Institutional Information Technology Committee

2013- Present

School of Medicine Council- Alternate

Tumor Boards 20 1 0- Present

GI Tumor Board

20 1 0- Present

GYN Tumor Board

20 1 0- Present

Liver Tumor Board

Navesh K. Sharma, DO, PhD

2010- Present

Lymphoma & Leukemia Tumor Board

2010- Present

Pediatric Tumor Board

Other “Ask the Expert” (www.umm.edu website) – SIR – Spheres Therapy

2010- Present

Institutional (UMM-UCH) Committees 2013- Present

Cancer Advisory Board

2013- Present

Cancer Committee

2013- Present

Breast Cancer Committee

Tumor Boards

2013- Present

Thoracic Tumor Board

2013- Present

Breast Tumor Board

2013- Present

General Tumor Board

2013- Present

Lymphoma Tumor Board

2013- Present

HMH Oncology Conference

Local/Regional 2010- 2013

Pediatric Tumor Board, Children's National Medical Center (Washington, DC)

Editorial Service 2010- Present

Associate Editor, ASTRO Radiation and Cancer Biology Practice Exam

Navesh K. Sharma, DO, PhD

Ad hoc Journal Review 2009- Present

American Journal of Clinical Oncology

2009- Present

Cancer

2011- Present

Journal of Nuclear Medicine and Radiation Therapy

2011- Present

Radiotherapy and Oncology

2011- Present

Cancer Chemotherapy and Pharmacology

2012- Present

Radiation Oncology

2013- Present

Thoracic Cancer

National Examination Question Writer 2009- Present

ASTRO Annual Radiation and Cancer Biology Examination Guide

Publications

Peer-Reviewed Journal Articles

Luo J, Sharma NK, Seftor EA, DeLarco JE, Heidger PM, Hendrix MJC, Lubaroff DM. (1997). Heterogeneous Expression of lnvasive and Metastatic Properties in a Prostate Tumor Model. Pathol. Oncol. Res., 3: 264-271.

Sharma NK, Luo J, Kirschmann DA, O'Malley Y, Robbins ME, Akporiaye ET, Lubaroff DM, Heidger PM, Hendrix MJC. (1999). A Novel Immunological Model for the Study of Prostate Cancer. Cancer Res., 59: 2271-276.

Sharma NK, Seftor RE, Seftor EA, Gruman LM, Heidger PM, Cohen MB, Lubaroff DM, Hendrix MJC. (2002). Prostatic Tumor Cell Plasticity Involves Cooperative Interactions of Distinct Phenotypic Subpopulations: Role in Vasculogenic Mimicry. Prostate, 50(3): 189201.

Sharma NK, Sorosky JI, Bender D, Fletcher MS, Sood AK. (2005). Malignant Mixed Mullerian Tumor (MMMT) of the Cervix. Gynecol. Oncol., 97(2): 442-5.

Navesh K. Sharma, DO, PhD

Anderson P, Freedman GM, Sharma NK, Nicolaou N, Topham N, Morrow M. (2009). Postmastectomy Chest Wall Radiation to a Temporary Tissue Expander or Permanent Breast Implant- Is There a Difference in Complication Rates? Int. J. Rad. Oncol. Biol. Phys., 74(1):81-5.

Sharma NK, Cohen RJ, Eade TN, Buyyounouski MK, LiJ, McNeeley S, Crawford K, Chen YT, Uzzo RG, Horwitz, EM. (2009). An Intra-operative Real-time Sleeved Seed Technique for Permanent Prostate Brachytherapy. Brachytherapy, 9(2): 126-30.

Turaka A, Li T, Sharma, NK, Li L, Nicolaou N, Mehra R, Burtness B, Cohen RB, Lango MN, Horwitz EM, Ridge JA, Feigenberg SJ. (2010). Increased Recurrences Using Intensity Modulated Radiation Therapy in the Postoperative Setting. Am. J. Clin. Oncol., 33(6):599-603.

Cohen RJ, Sharma NK, Yu JQ, Wang L, Buyyounouski MK, Unger M, Borghaei H, King E, Scott W, Callahan E, Movsas B, and Feigenberg SJ (2010). A Phase I Radiation Dose Escalation of Stereotactic Body Radiotherapy for Malignant Lung Tumors. J. Biomed. Sci. Engg., 3(4):351-358.

Sharma NK, Li TL, Pollack A, Chen YT, Horwitz EM, Buyyounouski MK. (2011). Intensity Modulated Radiation Therapy Reduces Gastrointestinal Morbidity in Patients Treated with Androgen Deprivation Therapy for Prostate Cancer. Int. J. Rad. Oncol Biol. Phys., 80(2):43 7-44.

10.

Sharma NK, Silverman JS, Li TL, Cheng J, Yu JQ, Haluszka O, Scott W, Meropol NJ, Cohen SJ, Freedman GM, Konski AA. (2011). Decreased Post-treatment SUV on PET Scan is Associated With Improved Local Control in Medically Inoperable Esophageal Cancer: The Fox Chase Cancer Center Experience. Gastrointest. Cancer Res., 4(3):84- 89.

11.

Sharma NK, Pandya NB, Wong RK, Herman JM, Hanna NN, Laheru DA, Major P, Alexander HR, Kennedy NL, Regine WF. (2012). Evaluation of Low-Dose Fractioned Radiation Therapy as a Gemcitabine Chemopotentiator in Advanced Pancreas Cancer. J. Rad. Oncol. (Submitted).

12.

Lubbe W, Cohen R, Sharma NK, Ruth K, Peter R, Li J, Buyyounouski M, Kutikov A, Chen D, Uzzo R, Horwitz E. (2012). Biochemical and Clinical Experience with Real-Time Intraoperatively Planned Permanent Prostate Brachytherapy. Brachytherapy, 11(3):209-13.

13.

Mahmood U, Errens M, Zimrin A, Hanna N, Amin P, Sharma NK. (2012). The Remarkably Distensible Stomach: Case Report Highlighting Its Implications For Radiation Treatment Planning. Practical Rad. Oncol. 2(4):265-69.

14.

Sharma NK, Silverman JS, Scott WJ, Borghaei H, Buyyounouski M, Movsas B, and Feigenberg SJ. (2012). FDG-PET Scans in the Management of Patient Care Following Stereotactic Body Radiotherapy for Lung Cancer: A Surrogate for Response? Thoracic Cancer (In review)

Navesh K. Sharma, DO, PhD

15. Nichols RC Jr, Huh SN, Prado KL, Yi BY, Sharma NK, Ho MW, Hoppe BS, Mendenhall NP, Regine WF. (2012). Protons Offer Reduced Normal-Tissue Exposure for Patients Receiving Postoperative Radiotherapy for Resected Pancreatic Head Cancer. Int. J. Rad. Oncol. Biol. Biophys., 83(1): 158-63.

16. Feigenberg SJ, Campassi C, Sharma NK, Kesmodel SB, Tkaczuk K, Yu JQ. (2012). Integration of Modern Imaging Into the Multidisciplinary Setting: The Radiation Oncology Perspective. Applied Radiol. 41(3): 24-30.

17. Reese A, Feigenberg SJ, Husain Z, Webb TJ, Hausner PF, Edelman MJ, Feliciano J, Tkaczuk K and Sharma NK. (2013). Stereotactic Ablative Therapy: Im pact on the Immune System and Potential for Future Therapeutic Modulation. Mol. Cell. Pharmacol. (Accepted).

18. Reese AS, Yang X, Laser B, Lu W, Sharma NK, Feigenberg SJ, Regine WF, Yi B. (2013). Deformable Image Registration (DIR) as a Method to Assess Motion for Pancreatic Cancer using 4D Computed Tomography (CT) Scans, J. of Applied Clin. Medical Physics (In Revision).

19. Nguyen, D. M., Chang, E.T., Sharma, N., and Carrier, F. (2013). Contribution of Dual Oxidase 2 (DUOX2) to Hyper Radiosensitivity in Human Gastric Cancer Cells, Radiation Research (In review). Invited Commentaries 1.

Sharma NK and Regine W. (2011) Radiation Therapy in Resected Pancreatic Cancer: Clearing Up the Fog. Oncol., 25(8): 1-3.

Book Chapters

Hendrix MJC, Luo J, Seftor EA, Sharma NK, Heidger PM, Cohen MB, Bhatty R, Chunthapong J, Seftor REB, Lubaroff DM. (2007) Epithelial-mesenchymal Molecular Interactions in Prostatic Tumor Cell Plasticity. In Metastasis of Prostate Cancer Ablin RJ, and Mason MD, eds.; Springer: Amsterdam, Vol. 10, pp 127-141.

Feigenberg SJ, Cohen R, Sharma NK, Husain Z, Chen S and Dawson LA. (2013) Stereotactic Body Radiation Therapy. In Principles and Practice of Stereotactic Radiosurgery, 2nd edition, Chin L and Regine WF, eds.; Springer: New York (In press)

Selected Abstracts Oral Presentation

Maniotis AJ, Hess AR, Seftor REB, Seftor EA, Sharma N, Gruman-Gardner LM, Folberg R, and Hendrix MJC. Vascular Channel Formation by Human Melanoma Cells In Vitro and In Vivo: Vasculogenic Mimicry. Oral presentation at the ARVO annual meeting, April 1998.

Sharma N, Seftor REB, Seftor EA, Heidger PM, Cohen MB, Folberg R, Miller, GJ, Lubaroff DM, and Hendrix MJC. Vasculogenic Mimicry by Aggressive Prostate Cancer: Molecular Mechanisms Contributing to Invasive Behavior. Oral presentation at the FASEB Annual Meeting, April 2000. FASEB J. 14: A272, 2000.

Navesh K. Sharma, DO, PhD

Sharma NK, Seftor REB, Seftor EA, Lubaroff DM, Heidger PM and Hendrix MJC. Dynamic Remodeling of Prostate Adenocarcinoma Microenvironment: Role of lndividual Tumor Cell Populations in Development of Patterned Tubular Intratumoral Networks. Oral presentation at the Society for Basic Urologic Research Fall Symposium, November, 2000.

Sharma NK. Dynamic Remodeling of Prostatic Adenocarcinoma Microenvironment by Tumor Cells: A Mechanism for Tumor Survival and Dissemination? Oral presentation at the 10th Annual U H S Research Symposium, January 2002.

Sharma NK, Sharma CG, and Peffley OM. Genistein, Perillyl Alcohol and y-Tocotrienol Differentially Influence PC3 and DU145 Prostate Cancer Cells In Vitro. Oral presentation at the 11th Annual UHS Research Symposium, January 2003.

Sharma NK, Pollack A, Horwitz EM, Li T, and Buyyounouski MK. Intensity Modulate Radiation Therapy Reduces Gastrointestinal Morbidity in Patients Treated with Androgen Deprivation Therapy for Prostate Cancer. Oral Presentation at the 49th ASTRO annual meeting, October, 2007. Int. J. Rad. Oncol. Biol. Phys., 69 (3): SI O, 2007.

Sharma NK, Silverman JS, Li T, Cheng J, Yu JQ, Haluszka O, Scott W, Meropol N, Cohen SJ, Freedman GM, and Konski AA. Decreased Post-Treatment SUV on PET Scan is Associated With Improved Local Control in Medically Inoperable Esophageal Cancer: The Fox Chase Cancer Center Experience. Oral presentation at the 90th ARS annual meeting, May, 2008. Oncology, ' 22(4): 7, 2008.

Sharma NK, Ruth K, Yu JQ, Nicolaou N, Buyyounouski MK, Konski AA Movsas B, and Feigenberg SJ. A 55% Decrease in Maximal 18-Flurodeoxyglucose Positron Emission Tomography (FDG-PET) Standardized Uptake Value (SUV) May Predict for Local Control Following Image Guided Stereotactic Body Radiotherapy (IGSBRT) for Lung Cancer. Oral presentation at the 4th International Conference on Translational Research March, 2009. Radiother. Oncol., 90(3):S46, 2009.

Sharma NK, Ruth K, Movsas B, Yu JQ, Buyyounouski MK, Konski AA, Lally BE, and Feigenberg SJ. A Low Initial Standardized Uptake Value on FDG-PET Scan May Predict for Decreased Local Control in Patients Treated with Image Guided Stereotactic Body Radiotherapy (IGSBRT) for Lung Cancer. Oral presentation at the 91st ARS annual meeting, April, 2009.

10. Sharma NK, Harris, J, Horwitz EM, Langer CJ, Nicolaou N, Kies M, Curran WJ, Wong S, Ang KK. Age, Performance Status and Interval From Prior Radiation Therapy to Recurrence Predict for Overall Survival (OS) in Re-irradiated Head and Neck Cancer Patients Treated on RTOG 9911: Results of a Recursive Partitioning Analysis. Plenary presentation at the ATSRO/ASCO/AHNS multidisciplinary head and neck cancer meeting, February 2010.

11. Sharma NK, Seftor REB, Seftor EA, Lubaroff DM, Heidger PM and Hendrix MJC. Dynamic Remodeling of Prostate Adenocarcinoma Microenvironment: Role of lndividual Tumor Cell Populations in Development of Patterned Tubular Intratumoral Networks. Oral presentation at the Society for Basic Urologic Research Fall Symposium, November, 2000.

Navesh K. Sharma, DO, PhD

12.

13.

14.

15.

16.

17.

18.

Sharma NK, Harris, J, Horwitz EM, Langer CJ, Nicolaou N, Kies M, Curran WJ, Wong S, Ang KK. Age, Performance Status and Interval From Prior Radiation Therapy to Recurrence Predict for Overall Survival (OS) in Re-irradiated Head and Neck Cancer Patients Treated on RTOG 9911: Results of a Recursive Partitioning Analysis. Plenary presentation at the ATSRO/ASCO/AHNS multidisciplinary head and neck cancer meeting, February 2010.

19.

Sharma NK, Pandya N, Wong R, Herman J, Hanna NN, Laheru DA, Major P, Alexander HR, Kennedy N, Regine WF. Low Dose Upper Abdominal Radiation Therapy (LD- UART) Potentiates Gemcitabine in Patients with Advanced, Unresectable Pancreatic Cancer (PC): Final Results from a Phase II Multi-Institutional Study. Int. J. of Rad Onc. Biol. Phys., 78(3): S103, 2010.

Navesh K. Sharma, DO, PhD

20. Garofalo M, Moughan J, Hong T, Bendell J, Berger A, Lerma F, Lee R, Anne P, Sharma NK, Crane C. RTOG 0822: A Phase II Study of Preoperative (PREOP) Chemoradiotherapy (CRT) Using IMRT in Combination with Capecitabine (C) and Oxaliplatn (O) for Patients with Locally Advanced Rectal Cancer. Int J. of Rad. Oncol. Biol. Phys., 81(2): S3-4, 2011.

21. Kennedy AS, Ball D, Cohen S, Cohn M, Coldwell A, Drooz A, Ehrenwald E, Kanani S, Moeslein FM, Nutting CW, Putnam SG, Rose SC, Savin M, Schirm S, Sharma NK and Wang E. Multicenter Comparison of Safety and Efficacy of Yttrium-90 Resin Microspheres in Elderly (2: 70 years) and Younger Patients with Unresectable Liver- Dominant Metastatic Colorectal Cancer. CIRSE meeting, September 2013. Poster Presentation

Sharma N, Luo J. Seftor EA, DeLarco JE, Heidger PM, Hendrix MJC and Lubaroff DM. Phenotypic Correlates of Invasion in Prostatic Cancer Cells. Poster presentation at the AACR annual meeting, April 1997. Proc. Amer. Assoc. Cancer Res., 38: 547, 1997.

Luo J, Sharma N, Seftor EA, Heidger PM, Lubaroff DM, and Hendrix MJC. Heterogeneous Expression of E-cadherin/catenin Complex and its Modulation by E- cadherin Transfection in Prostate Cancer Cells. Poster presentation at the AA CR annual meeting, April 1998. Proc. Amer. Assoc. Cancer. Res., 39: 500, 1998.

Sharma N, Luo J, Lubaroff DM, Heidger PM, and Hendrix MJC. A Novel Tumor- Immunological Model for the Study of Prostate Cancer. Poster presentation at the AACR annual meeting, April 1998. Proc. Amer. Assoc. Cancer. Res., 39: 614, 1998.

Sharma N, Luo J, Maniotis AJ, Kirschmann DA, Heidger PM, Lubaroff DM, and Hendrix MJC. Tumor Cell Mediated Immunosuppression and Angiogenesis in the Dunning Gelatin-Sponge Retrieval System. Poster presentation at the AACR special meeting “New Research Approaches in the Prevention and Cure of Prostate Cancer,” December 1998.

Sharma NK, Seftor REB, Seftor EA, Lubaroff DM, Heidger PM and Hendrix MJC. Formation of Patterned Intratumoral Networks in Aggressive Heterogeneous Prostate Cancer: Molecular Determinants and Role of Individual Populations. Poster presentation at the AACR annual meeting, April 2001. Proc. Amer. Cancer. Res., 42: 110, 2001.

Sharma NK, Hentosh P, and Peffley DM. Differential Inhibition of lnvasive Properties in PC3 and DU I 45 Prostate Cancer Cells by Genistein, Perillyl Alcohol and y-Tocotrienol. Poster presentation at the AACR annual meeting, July 2003. Proc. Amer. Assoc. Cancer Res.,44: 611, 2003.

Navesh K. Sharma, DO, PhD

Sharma NK, Sharma CG, and Peffley DM. Inhibition of Molecular Pathways Involved in Prostatic Adenocarcinoma Invasion and Metastasis by Genistein and Perillyl Alcohol: A Potential Therapeutic Intervention Strategy? Poster presentation at the 12th Annual UHS Research Symposium, January 2004.

Sharma NK, Ruth K, Horwitz E, Buyyounouski M, and Pollack A. Statin use During Radiation Therapy Does not Improve Outcome: The Fox-Chase Experience. Poster presentation at the 48th ASTRO annual meeting, November 2006. Int. J. Rad. Oncol. Biol. Phys., 66(3): S366, 2006.

10.

Feigenberg SJ, Sharma NK, Wang L, Cohen R, Buyyounouski MK, Lally BE, and Movsas B. Phase I Dose Escalation Trial of Image Guided Stereotactic Body Radiotherapy for Lung Tumors. Poster discussion at the 50th annual ASTRO meeting, September, 2008. Int. J. Rad. Oncol. Biol. Phys., 72(1): SJ 14, 2008.

11. Sharma NK, Ruth K, Konski AA, Buyyounouski MK, Nicolaou N, Lally BE, Yu JQ, Langer CJ, Movsas B, and Feigenberg SJ. Low Morbidity and Excellent Local Control Using Image Guided Stereotactic Body Radiotherapy (IGSBRT) for Lung Tumors. Poster Presentation at the 50th annual ASTRO meeting, September, 2008. Int. J. Rad. Oncol. Biol. Phys., 72(1): S454, 2008.

12. Cohen RJ, Sharma NK, Li J, Ruth KJ, Buyyounouski MK, Crawford K, Uzzo RG, Horwitz EM. Sleeved Seeds Decrease Post-implant Hotspots in Real-time Intra- operatively Planned Permanent 1-125 Prostate Implants. Poster presentation at the 2009 annual ABS meeting, May, 2009. Brachytherapy, 8(2): 179.

13. Sharma NK, Cohen RJ, Ruth KJ, Crawford K, Li J, Buyyounouski MK, Feigenberg SJ, Uzzo RG, Horwitz EM. Sleeved Seeds Decrease Gastrointestinal and Genitourinary Toxicity Profiles in Real-time Intra-operatively Planned Permanent 1-125 implants. Poster presentation at the 2009 Annual ABS meeting, May, 2009. Brachytherapy, 8(2): 179.

14. Cohen RJ, Sharma NK, Ruth KJ, Buyyounouski MK, Li J, Crawford K, Feigenberg SJ, Chen DYT, Uzzo RG, Horwitz EM. Is MRI-based Week Three Post-implant Dosimetry Necessary following LDR Prostate Brachytherapy? Poster presentation at the 51st annual ASTRO meeting, November 2009. Int. J. Rad. Oncol. Biol. Phys., 75(3): S298, 2009.

15. Horwitz EM, Ruth KJ, Sharma NK, Chen DYT, Buyyounouski MK, Uzzo RG. Undetectable Post-treatment PSA Following 3DCRT or IMRT Alone for Patients with Low or Intermediate Risk Prostate Cancer is an Independent Predictor of Biochemical and Clinical Outcome. Poster presentation at the 51st annual ASTRO meeting, November 2009. Int. J. Rad. Oncol. Biol. Phys., 75(3): S301, 2009.

Navesh K. Sharma, DO, PhD

16. Sharma NK, Ruth KJ, Boorjian SA, Uzzo RG, Buyyounouski MK, Horwitz EM. Initial PSA (iPSA) and Radiation Dose Predict for an Undetectable PSA Following 3DCRT or IMRT for Lowintermediate Risk Prostate Cancer. Poster presentation at the 51st annual ASTRO meeting, November 2009. Int. J. Rad. Oncol. Biol. Phys., 75(3): S313, 2009.

17. Nichols R, Huh S, Prado K, Yi BY, Sharma NK, Ho MW, Hoppe BS, Mendenhall WM, Mendenhall NP, Regine WF. Protons Offer Reduced Normal Tissue Exposure for Patients Receiving Postoperative Radiotherapy (RT) for Resected Pancreatic Head Cancer, Poster Presentation at the 52nd annual ASTRO meeting, November 2010. Int, J. of Rad Oncol. Biol. Phys., 78(3): S332, 2010.

18. Horwitz EM, Sharma NK, Ruth K, Silverman JS, Buyyounouski MK, Chen DYT, Greenberg RE, Uzzo RG. The Role of Adjuvant and Salvage Post-Prostatectomy IMRT or 3DCRT: The Fox Chase Experience, Poster Presentation at the 52nd annual ASTRO meeting, November 2010. Int, J. of Rad Onc. Biol. Phys., 78(3): S333-8334, 2010.

19. Sharma NK, Mahmood U, Hanna N, Alexander HR, Pandya N, Horiba M, and Regine WR. Effects of Racial/Social Factors and INT-0116/MAGIC Trials Publication on Radiation Therapy (RT) Utilization for Gastric Cancer. Int. J. of Rad Oncol. Biol. Phys., 81(2): S327, 2011.

20.

Nichols EM, Grabowski S, Hanlon A, Regine WR, Patel R, Kudryasheva S, Garofalo M, Amin P, Moeslein F, and Sharma NK. Performance Status (PS), Number of Lesions and Interval from Metastatic Diagnosis to Treatment (IMDTT) Predict for Overall Survival (OS) in Patients Treated with Hepatic Transarterial Radioembolization (TARE) using Yttrium-90 (Y90) Microspheres. Int. J. Rad. Oncol. Biol. Phys., 81(2): S2281, 2011.

21.

Grabowski S, Nichols EM, Hanlon A, Regine WR, Patel R, Kudryasheva S, Garofalo M, Amin P, Moeslein F, and Sharma NK. The Efficacy of Selective Internal Radiation therapy (SIRT) with Yttrium-90 (Y90) is Enhanced When Given in Low Volume Disease and in Conjunction With Other Liver-Directed Therapies. Int. J. Rad. Oncol. Biol. Phys., 81(2): S2296, 2011.

22.

Sharma NK, Nichols EM, Grabowski S, Amin P, Garofalo M, Hanlon A, Patel R, Horiba M and Moeslein F. Early Intervention with Selective Internal Radiation Therapy (SIRT) Improves Local/Systemic Options. Radiother. Oncol., 103(2): S161, 2012.

23.

Kennedy AS, Ball D, Cohen SJ, Cohn M, Coldwell DM, Drooz A, Ehrenwald E, Kanani S, Rose SC, Nutting CW, Moeslein FM, Savin M, Schirm Sabine, Sharma NK, Wang E., U.S. patients receiving resin 90Y microspheres for unresectable colorectal liver metastases: A multicenter study of 506 patients. J. Clin. Oncol., 30, 2012.

Navesh K. Sharma, DO, PhD

24. Yang X, Reese AS, Mutaf YD, Prado KL, Sharma NK, Feigenberg SJ, Regine WF, Yi B. Dosimetric Validation of Respiratory Motion Margins for Patients With Pancreatic Cancer Using Deformable 40 Contour Propagation. Int. J. Rad. Oncol. Biol. Phys., 84(3): S778- 8779, 2012.

25.

Lu W, Sharma NK, Feigenberg SJ, Regine WF, Yi B. Deformable Image Registration as a Method to Assess Motion for Pancreatic Cancer Using 4D Computed Tomography (CT) Scans. Int. J. Rad. Oncol. Biol. Phys., 84(3): S771, 2012.

26. Kennedy AS, Ball D, Cohen S, Cohn M, Coldwell A, Drooz A, Ehrenwald E, Kanani S, Moeslein FM, Nutting CW, Putnam SG, Rose SC, Savin M, Schirm S, Sharma NK and Wang E. Safety and Efficacy of Yttrium-90 Resin Microspheres in Elderly (> 70 years) Compared to Younger Patients with Colorectal Liver Metastases. ASCO meeting, June 2013.

27.

Sharma NK, Chaudhry H, Horiba M, Hanna NN, Alexander HR, Hausner PF, Regine WF, Amin PP, Kudryasheva S, Moeslein FM. Association Between K-ras Mutation Status And Survival In mCRC Patients Undergoing Selective Internal Radiation Therapy (SIRT) to the Liver Using Yttrium-90 Coated Resin Microspheres. ASTRO meeting, September 2013.

28. Rutenberg MS, Errens MA, Sharma NK, Yang X, Yi B, Regine WF. A Comparison Between Consensus Guidelines Based PTVs And 4D-CT Based PTVs For Locally Advanced Pancreatic Cancer: Implications For Therapy. Digital poster discussion at the ASTRO meeting, September 2013.

29.

Carrier F, Chang ET, Nguyen D, Sharma NK. Investigation of Low Dose Fractionated Radiation Therapy as a Chemopotentiator in Advanced/Metastatic Gastrointestinal Carcinoma. ASTRO meeting, September 2013.

30.

Mooney K, Chen S, Feigenberg SJ, Sharma NK, D'Souza WD. A Population-based Treatment Margin for Respiratory Motion of Lung Tumors. ASTRO meeting, September 2013.

31. Chaudhry HE, Ellison TA, Maidment III BW, Regine WF, Alexander HR, Hanna NN, Wolfgang CL, Morris CG, Herman JM, Sharma NK. Radiation Therapy in Pancreatic Neuroendocrine Tumors: Favorable Outcomes and Low Toxicity in a Multi-Institutional Experience. ASTRO meeting, September 2013.

32.

Cohen RJ, Li L, Mahmood U, Hanlon A, Citron W, Oh M, Dragula C, Cheston S, Sharma NK, Feigenberg SJ. Adjuvant Radiation Improves Breast Cancer Specific Survival in the Eldest EarlyStage Breast Cancer Patients. ASTRO meeting, September 2013.

Navesh K. Sharma, DO, PhD

Authored Research Protocols

Sharma NK, Mehra R, Feigenberg SJ (co-principal investigators). A Phase I Study to Determine the Maximum Tolerable Dose (MTD) and Safety of the Mammalian Target of Rapamycin (mTOR) Inhibitor, RAD00 l , With Erlotinib™ and Concurrent External Beam Radiotherapy in the Reirradiation Setting for Squamous Cell Carcinoma of the Head and Neck.

Sharma NK (PI). GCC1324: Neoadjuvant FOLFIRINOX and Stereotactic Body Radiotherapy (SBRT) Followed by Definitive Surgery for Patients with Borderline Resectable Pancreatic Adenocarcinoma: A Single Arm Pilot Study.

Sharma NK (PI). GCC 1314: Low Dose Fractionated Radiation Therapy as a Chemopotentiator of FOLFOX Treatment in Select Rectal Cancer Patients Treated with a Neoadjuvant Combined Modality Approach.

Invited Lectures UMSOM, Dept. Of Internal Medicine Sep 27, 2010

Radiation Oncology Emergencies and Appropriate Management

UMSOM, Dept. Of Family Medicine Oct 26, 2010

Principles of Radiation Oncology

School of Medicine Lectures UMSOM Cancer Interest Group (approx. 50 attendees) Nov 5, 2010

The Role of Radiation Oncology in Gynecologic Cancers and Why Radiation Oncology is an Excellent Career Choice

Grand Rounds, UMSOM, Division of Medical Oncology Nov 24, 2010

Selective Internal Radiation Therapy and Stereotactic Body Radiotherapy in the Management of Liver Tumors

University of Maryland Colorectal Cancer Conference Apr 8, 2011

Rectal Cancer- Past, Present and Future Roles for RT

UMSOM, Dept. Of Surgery Jun 9, 2011

Surgery and RT - Complementary Local Modalities

UMSOM, Division of Medical Oncology Jun 16, 2011

Combined Modality Therapy and the Role of Radiation Oncology

Navesh K. Sharma, DO, PhD

SIRFLOX International Investigators Meeting Oct 16, 2011

Selective Internal Radiation Therapy using Y90 Microspheres: A Radiation Oncologists Perspective

Community Clinical Lecture: Frederick Hematology Oncology Nov 11, 2011

The SIRFLOX Trial: Improving Recruitment and Maintaining Quality

7th Annual Mid-Atlantic ASTRO Review Course Jan 5, 2012

Lymphoma/Sarcoma- Best of ASTRO

UMSOM, Dept. of Obstetrics/Gynecology May 1, 2012

Radiation Oncology in the Management of Gynecologic Malignancies

UMSOM, Division of Transplant Surgery Jul 2, 2012

Radiation Therapy in Liver Malignancies- Changing Perspectives

Carolinas Medical Center, Liver Oncology Section Nov 13, 2012

Liver Directed Therapy Using Y90 Labeled Microspheres

Upper Chesapeake Medical Center Dec 12, 2012

Radiation Safety and Fluoroscopy

Jul 23, 2013

Fluoroscopy Radiation Safety

Nov 12, 2013

Safe Usage of Medical Fluoroscopy

8th Annual Mid-Atlantic ASTRO Review Course Jan 10, 2013

Gynecological Malignancies- Best of ASTRO

FOXFIRE Global Investigators Meeting Mar 9, 2013

Improving Outcomes in Liver Predominant mCRC with Combined Modality Therapy

Nov 13, 2013

FOXFIRE SIV Global Update

Navesh K. Sharma, DO, PhD

UMSOM, Division of Medical Oncology Apr 5, 2013

Technological Advances in Radiation Oncology- Reduced Toxicity Through Improved Targeting

Women in Defense: Aberdeen Proving Ground Oct 10, 2013

Breast Cancer Awareness

14th Annual MedStar Health Radiation Oncology Symposium

Oct 19, 2013

Y90 Radioembolization for Primary and Metastatic Liver Tumors

REFERENCES

Available upon request

Navesh K. Sharma, DO, PhD